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Identification
NamePhentermine
Accession NumberDB00191  (APRD00093)
TypeSmall Molecule
GroupsApproved, Illicit
Description

A central nervous system stimulant and sympathomimetic with actions and uses similar to those of dextroamphetamine. It has been used most frequently in the treatment of obesity. [PubChem]. Some common brand names for phentermine are Adipex-P® and Suprenza™. Phentermine is also available in combination medications such as Qsymia®.

Structure
Thumb
Synonyms
SynonymLanguageCode
alpha,alpha-DimethylphenethylamineNot AvailableNot Available
FenterminaNot AvailableNot Available
PhenterminumNot AvailableNot Available
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Suprenzatablet, orally disintegrating15 mgoralAkrimax Pharmaceuticals, LLC2012-12-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Suprenzatablet, orally disintegrating30 mgoralAkrimax Pharmaceuticals, LLC2012-12-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Suprenzatablet, orally disintegrating37.5 mgoralAkrimax Pharmaceuticals, LLC2012-12-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Phentermine Hydrochloridecapsule30 mgoralTeva Pharmaceuticals USA Inc2011-10-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule15 mgoralTeva Pharmaceuticals USA Inc2011-03-09Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule15 mgoralEon Labs, Inc.1981-06-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule30 mgoralEon Labs, Inc.1981-06-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule30 mgoralEon Labs, Inc.1981-06-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule30 mgoralLannett Company, Inc.2007-12-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule30 mgoralLannett Company, Inc.2007-12-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule30 mgoralLannett Company, Inc.2007-12-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule30 mgoralLannett Company, Inc.2010-07-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralLannett Company, Inc.2005-04-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule15 mgoralLannett Company, Inc.2012-01-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule37.5 mgoralLannett Company, Inc.2011-07-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralQualitest Pharmaceuticals2002-01-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule30 mgoralBlenheim Pharmacal, Inc.2013-03-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule15 mgoralBlenheim Pharmacal, Inc.2013-03-18Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralBlenheim Pharmacal, Inc.2009-12-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule37.5 mgoralBlenheim Pharmacal, Inc.2010-03-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule30 mgoralBlenheim Pharmacal, Inc.2010-03-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralBlenheim Pharmacal, Inc.2009-12-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule30 mgoralBlenheim Pharmacal, Inc.2010-05-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralKvk Tech, Inc.2012-08-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule15 mgoralKvk Tech, Inc.2012-08-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule30 mgoralKvk Tech, Inc.2012-08-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule30 mgoralKvk Tech, Inc.2012-08-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule37.5 mgoralKvk Tech, Inc.2012-08-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule30 mgoralApotheca, Inc.1998-06-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule30 mgoralApotheca, Inc.2010-01-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule15 mgoralApotheca, Inc.1999-11-08Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule37.5 mgoralApotheca, Inc.1999-11-08Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralApotheca, Inc.2002-08-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralAurolife Pharma, LLC2011-06-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule30 mgoralSTAT Rx USA LLC2007-12-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralSTAT Rx USA LLC2003-10-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule15 mgoralRebel Distributors Corp1999-11-08Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule30 mgoralRebel Distributors Corp1983-02-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralRebel Distributors Corp.2003-10-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralCamber Pharmaceuticals, Inc.2014-04-02Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule15 mgoralAidarex Pharmaceuticals LLC2012-08-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule30 mgoralAidarex Pharmaceuticals LLC2012-08-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule37.5 mgoralAidarex Pharmaceuticals LLC2012-08-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralAidarex Pharmaceuticals LLC2012-08-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralRx Change Co.2014-11-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule37.5 mgoralPd Rx Pharmaceuticals, Inc.2012-08-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralPd Rx Pharmaceuticals, Inc.2003-10-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule30 mgoralPd Rx Pharmaceuticals, Inc.2007-12-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralPd Rx Pharmaceuticals, Inc.2011-03-08Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralPd Rx Pharmaceuticals, Inc.2005-04-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralLake Erie Medical DBA Quality Care Products2012-08-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule30 mgoralA S Medication Solutions Llc2012-08-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Adipex-ptablet37.5 mgoralA S Medication Solutions Llc1990-09-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule30 mgoralA S Medication Solutions Llc2007-12-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule30 mgoralA S Medication Solutions Llc2012-08-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralA S Medication Solutions Llc2012-08-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralA S Medication Solutions Llc2012-08-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule15 mgoralA S Medication Solutions Llc2012-08-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule37.5 mgoralA S Medication Solutions Llc2012-08-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralA S Medication Solutions Llc2003-10-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet30 mgoralA S Medication Solutions Llc2013-08-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralUnit Dose Services2003-10-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule30 mgoralUnit Dose Services2003-10-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule30 mgoralUnit Dose Services2012-08-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule37.5 mgoralUnit Dose Services2012-08-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralUnit Dose Services2005-04-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralUnit Dose Services2003-10-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule30 mgoralUnit Dose Services2012-08-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule30 mgoralUnit Dose Services1981-06-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule15 mgoralUnit Dose Services2012-08-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralTAGI Pharma, Inc.2011-03-08Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule30 mgoralTAGI Pharma, Inc.2013-04-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule15 mgoralTAGI Pharma, Inc.2013-04-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralNorthwind Pharmaceuticals2014-05-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralNorthwind Pharmaceuticals2014-06-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralNorthwind Pharmaceuticals2014-06-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralMirror Pharmaceuticals LLC2011-11-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule30 mgoralH.J. Harkins Company, Inc.2007-12-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralH.J. Harkins Company, Inc.2003-10-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralMutual Pharmaceutical Company, Inc.2003-10-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule30 mgoralMutual Pharmaceutical Company, Inc.2003-10-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet30 mgoralMutual Pharmaceutical Company, Inc.2013-08-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule30 mgoralA S Medication Solutions Llc2012-08-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Adipex-ptablet37.5 mgoralA S Medication Solutions Llc1990-09-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule30 mgoralA S Medication Solutions Llc2012-08-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralA S Medication Solutions Llc2012-08-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule15 mgoralA S Medication Solutions Llc2012-08-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule37.5 mgoralA S Medication Solutions Llc2012-08-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralA S Medication Solutions Llc2012-08-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralA S Medication Solutions Llc2003-10-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralPhysicians Total Care, Inc.2008-01-25Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule30 mgoralPhysicians Total Care, Inc.1995-02-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule15 mgoralPhysicians Total Care, Inc.1997-04-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule37.5 mgoralPhysicians Total Care, Inc.2011-07-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule30 mgoralPd Rx Pharmaceuticals, Inc.2003-10-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Adipex-ptablet37.5 mgoralPd Rx Pharmaceuticals, Inc.2011-02-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule30 mgoralPd Rx Pharmaceuticals, Inc.2012-08-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralPd Rx Pharmaceuticals, Inc.2003-10-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule15 mgoralPd Rx Pharmaceuticals, Inc.1997-04-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Adipex-ptablet37.5 mgoralTeva Select Brands1990-09-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Adipex-pcapsule37.5 mgoralTeva Select Brands1990-09-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralDIRECT RX2014-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralProficient Rx LP2013-08-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralbryant ranch prepack2002-01-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule30 mgoralbryant ranch prepack2007-12-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule15 mgoralbryant ranch prepack1997-04-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule37.5 mgoralbryant ranch prepack2012-08-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralbryant ranch prepack2012-08-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule15 mgoralbryant ranch prepack2012-08-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralbryant ranch prepack2002-01-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralbryant ranch prepack2003-10-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule30 mgoralbryant ranch prepack2010-07-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralElite Laboratories, Inc.2014-05-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralRising Pharmaceuticals, Inc.2012-09-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule30 mgoralDispensing Solutions, Inc.1998-06-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralDispensing Solutions, Inc.2003-10-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralKeltman Pharmaceuticals Inc.2007-07-31Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralLegacy Pharmaceutical Packaging2014-04-02Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule30 mgoralPreferred Pharmaceuticals, Inc.2014-01-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralPreferred Pharmaceuticals, Inc.2012-07-25Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralPreferred Pharmaceuticals, Inc.2011-09-22Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule30 mgoralPreferred Pharmaceuticals, Inc.2014-11-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralPreferred Pharmaceuticals, Inc.2014-12-22Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule15 mgoralPreferred Pharmaceuticals, Inc.2014-08-25Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule15 mgoralPreferred Pharmaceuticals, Inc.2012-08-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridecapsule30 mgoralPreferred Pharmaceuticals, Inc.2012-03-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phentermine Hydrochloridetablet37.5 mgoralLife Line Home Care Services, Inc.2008-03-31Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Over the Counter ProductsNot Available
International Brands
NameCompany
DuromineNot Available
FastinNot Available
IonaminNot Available
ObenixNot Available
Obestin-30Not Available
PhentercotNot Available
PhentrideNot Available
Pro-FastNot Available
TeramineNot Available
ZantrylNot Available
Brand mixtures
Brand NameIngredients
Fen-phenfenfluramine + phentermine
Qsymiaphentermine + topiramate extended-release
Salts
Name/CASStructureProperties
Phentermine Hydrochloride
1197-21-3
Thumb
  • InChI Key: NCAIGTHBQTXTLR-UHFFFAOYSA-N
  • Monoisotopic Mass: 185.097127224
  • Average Mass: 185.694
DBSALT000138
Categories
CAS number122-09-8
WeightAverage: 149.2328
Monoisotopic: 149.120449485
Chemical FormulaC10H15N
InChI KeyDHHVAGZRUROJKS-UHFFFAOYSA-N
InChI
InChI=1S/C10H15N/c1-10(2,11)8-9-6-4-3-5-7-9/h3-7H,8,11H2,1-2H3
IUPAC Name
2-methyl-1-phenylpropan-2-amine
SMILES
CC(C)(N)CC1=CC=CC=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as amphetamines and derivatives. These are organic compounds containing or derived from 1-phenylpropan-2-amine.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassPhenethylamines
Direct ParentAmphetamines and derivatives
Alternative Parents
Substituents
  • Amphetamine or derivatives
  • Phenylpropane
  • Aralkylamine
  • Hydrocarbon derivative
  • Primary amine
  • Organonitrogen compound
  • Primary aliphatic amine
  • Amine
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment and management of obesity.
PharmacodynamicsPhentermine is indicated in the management of exogenous obesity as a short term (a few weeks) adjunct in a regimen of weight reduction based on caloric restriction. Phentermine hydrochloride is a sympathomimetic amine with pharmacologic activity similar to the prototype drugs of this class used in obesity, the amphetamines. Actions include central nervous system stimulation and elevation of blood pressure. Tachyphylaxis and tolerance have been demonstrated with all drugs of this class in which these phenomena have been looked for.
Mechanism of actionPhentermine is an amphetamine that stimulates neurons to release or maintain high levels of a particular group of neurotransmitters known as catecholamines; these include dopamine and norepinephrine. High levels of these catecholamines tend to suppress hunger signals and appetite. The drug seems to inhibit reuptake of noradrenaline, dopamine, and seratonin through inhibition or reversal of the reuptake transporters. It may also inhibit MAO enzymes leaving more neurotransmitter available at the synapse.Phentermine (through catecholamine elevation) may also indirectly affect leptin levels in the brain. It is theorized that phentermine can raise levels of leptin which signal satiety. It is also theorized that increased levels of the catecholamines are partially responsible for halting another chemical messenger known as neuropeptide Y. This peptide initiates eating, decreases energy expenditure, and increases fat storage.
AbsorptionPhentermine is rapidly absorbed after oral ingestion.
Volume of distributionNot Available
Protein bindingApproximately 96.3%
Metabolism

Hepatic.

Route of eliminationNot Available
Half life16 to 31 hours
ClearanceNot Available
ToxicityLD50 is adult monkeys is 15 to 20 mg/kg. Symptoms of overdose include delirium, mania, self-injury, marked hypertension, tachycardia, arrhythmia, hyperpyrexia, convulsion, coma, and circulatory collapse.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9964
Blood Brain Barrier+0.959
Caco-2 permeable+0.7688
P-glycoprotein substrateNon-substrate0.6477
P-glycoprotein inhibitor INon-inhibitor0.934
P-glycoprotein inhibitor IINon-inhibitor0.9801
Renal organic cation transporterNon-inhibitor0.8236
CYP450 2C9 substrateNon-substrate0.8411
CYP450 2D6 substrateSubstrate0.7204
CYP450 3A4 substrateNon-substrate0.6493
CYP450 1A2 substrateNon-inhibitor0.7962
CYP450 2C9 substrateNon-inhibitor0.8861
CYP450 2D6 substrateInhibitor0.7825
CYP450 2C19 substrateNon-inhibitor0.8996
CYP450 3A4 substrateNon-inhibitor0.7348
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8782
Ames testNon AMES toxic0.9681
CarcinogenicityNon-carcinogens0.6949
BiodegradationNot ready biodegradable0.9303
Rat acute toxicity2.8400 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9867
hERG inhibition (predictor II)Non-inhibitor0.8734
Pharmacoeconomics
Manufacturers
  • Baxter healthcare corp anesthesia critical care
  • Teva pharmaceuticals usa inc
  • Glaxosmithkline
  • Ferndale laboratories inc
  • Shire richwood inc
  • Mm mast and co
  • Abc holding corp
  • Able laboratories inc
  • Actavis totowa llc
  • Barr laboratories inc
  • Camall co inc
  • Duramed pharmaceuticals inc sub barr laboratories inc
  • Ivax pharmaceuticals inc
  • Kvk tech inc
  • Lannett co inc
  • Lannett holdings inc
  • Mutual pharmaceutical co inc
  • Sandoz inc
  • Tg united inc
  • Tg united labs llc
  • Usl pharma inc
  • Vitarine pharmaceuticals inc
  • Watson laboratories inc
  • Actavis elizabeth llc
  • Caraco pharmaceutical laboratories ltd
  • Vintage pharmaceuticals inc
  • Solvay pharmaceuticals
  • Ucb inc
  • Quantum pharmics ltd
Packagers
Dosage forms
FormRouteStrength
Capsuleoral15 mg
Capsuleoral30 mg
Capsuleoral37.5 mg
Tabletoral30 mg
Tabletoral37.5 mg
Tablet, orally disintegratingoral15 mg
Tablet, orally disintegratingoral30 mg
Tablet, orally disintegratingoral37.5 mg
Prices
Unit descriptionCostUnit
Phentermine hcl powder10.71USD g
Ionamin 30 mg capsule sa2.87USD capsule
Adipex-P 37.5 mg capsule2.2USD capsule
Adipex-p 37.5 mg tablet2.15USD tablet
Phentermine 37.5 mg tablet1.54USD tablet
Phentermine HCl 15 mg capsule1.18USD capsule
Phentermine HCl 30 mg capsule1.17USD capsule
Ionamin 15 mg capsule sa1.15USD capsule
Phentermine HCl 37.5 mg capsule1.0USD capsule
Phentermine HCl 37.5 mg tablet1.0USD tablet
Phentermine 8 mg tablet0.54USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point205 °CNot Available
water solubility18.6 g/LNot Available
logP1.90HANSCH,C ET AL. (1995)
Predicted Properties
PropertyValueSource
Water Solubility0.757 mg/mLALOGPS
logP2.32ALOGPS
logP2.08ChemAxon
logS-2.3ALOGPS
pKa (Strongest Basic)10.25ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area26.02 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity48.34 m3·mol-1ChemAxon
Polarizability17.87 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (7.33 KB)
SpectraMS/MSMS1D NMR
References
Synthesis ReferenceNot Available
General Reference
  1. Bray GA: A concise review on the therapeutics of obesity. Nutrition. 2000 Oct;16(10):953-60. Pubmed
  2. Nelson DL, Gehlert DR: Central nervous system biogenic amine targets for control of appetite and energy expenditure. Endocrine. 2006 Feb;29(1):49-60. Pubmed
External Links
ATC CodesA08AA01
AHFS Codes
  • 28:20.92
PDB EntriesNot Available
FDA labelDownload (159 KB)
MSDSDownload (48.2 KB)
Interactions
Drug Interactions
Drug
AcebutololMay enhance the adverse/toxic effect of other Sympathomimetics.
AcepromazineMay diminish the stimulatory effect of Amphetamines.
AcetazolamideMay decrease the excretion of Amphetamines. Exceptions: Brinzolamide; Dorzolamide.
AcetophenazineMay diminish the stimulatory effect of Amphetamines.
Aluminum hydroxideMay decrease the excretion of Amphetamines.
AminophyllineMay enhance the adverse/toxic effect of other Sympathomimetics.
AmisulprideMay diminish the stimulatory effect of Amphetamines.
Ammonium chlorideMay decrease the serum concentration of Amphetamines. This effect is likely due to an enhanced excretion of amphetamines in the urine.
AmphetamineMay enhance the adverse/toxic effect of other Sympathomimetics.
ArformoterolMay enhance the adverse/toxic effect of other Sympathomimetics.
AripiprazoleMay diminish the stimulatory effect of Amphetamines.
armodafinilMay enhance the adverse/toxic effect of other Sympathomimetics.
ArticaineMay enhance the adverse/toxic effect of other Sympathomimetics.
AtomoxetineMay enhance the hypertensive effect of Sympathomimetics. AtoMOXetine may enhance the tachycardic effect of Sympathomimetics.
BenzphetamineMay enhance the adverse/toxic effect of other Sympathomimetics.
BenzquinamideMay diminish the stimulatory effect of Amphetamines.
CaffeineMay enhance the adverse/toxic effect of other Sympathomimetics.
Calcium carbonateMay decrease the excretion of Amphetamines.
CarphenazineMay diminish the stimulatory effect of Amphetamines.
ChlormezanoneMay diminish the stimulatory effect of Amphetamines.
ChlorphentermineMay enhance the adverse/toxic effect of other Sympathomimetics.
ChlorpromazineMay diminish the stimulatory effect of Amphetamines.
ChlorprothixeneMay diminish the stimulatory effect of Amphetamines.
ClenbuterolMay enhance the adverse/toxic effect of other Sympathomimetics.
ClozapineMay diminish the stimulatory effect of Amphetamines.
CocaineMay enhance the adverse/toxic effect of other Sympathomimetics.
DexmethylphenidateMay enhance the adverse/toxic effect of other Sympathomimetics.
DextroamphetamineMay enhance the adverse/toxic effect of other Sympathomimetics.
DiclofenamideMay decrease the excretion of Amphetamines. Exceptions: Brinzolamide; Dorzolamide.
DiethylpropionMay enhance the adverse/toxic effect of other Sympathomimetics.
DihydrocodeineMay enhance the adverse/toxic effect of other Sympathomimetics.
DipivefrinMay enhance the adverse/toxic effect of other Sympathomimetics.
DobutamineMay enhance the adverse/toxic effect of other Sympathomimetics.
DopamineMay enhance the adverse/toxic effect of other Sympathomimetics.
DoxapramMay enhance the adverse/toxic effect of other Sympathomimetics.
DronabinolCannabinoid-Containing Products may enhance the tachycardic effect of Sympathomimetics.
DroperidolMay diminish the stimulatory effect of Amphetamines.
EpinephrineMay enhance the adverse/toxic effect of other Sympathomimetics.
EthanolAlcohol (Ethyl) may enhance the adverse/toxic effect of Phentermine.
EthosuximideAmphetamines may diminish the therapeutic effect of Ethosuximide. Amphetamines may decrease the serum concentration of Ethosuximide.
EthoxzolamideMay decrease the excretion of Amphetamines. Exceptions: Brinzolamide; Dorzolamide.
FencamfamineMay diminish the stimulatory effect of Amphetamines.
FenoterolMay enhance the adverse/toxic effect of other Sympathomimetics.
FlupentixolMay diminish the stimulatory effect of Amphetamines.
FluphenazineMay diminish the stimulatory effect of Amphetamines.
FluspirileneMay diminish the stimulatory effect of Amphetamines.
Fluticasone furoateMay enhance the adverse/toxic effect of other Sympathomimetics.
FormoterolMay enhance the adverse/toxic effect of other Sympathomimetics.
HaloperidolMay diminish the stimulatory effect of Amphetamines.
IndacaterolMay enhance the adverse/toxic effect of other Sympathomimetics.
IobenguaneMay diminish the therapeutic effect of Iobenguane I 123.
Ioflupane I 123Amphetamines may diminish the diagnostic effect of Ioflupane I 123.
Ipratropium bromideMay enhance the adverse/toxic effect of other Sympathomimetics.
IsomethepteneMay enhance the adverse/toxic effect of other Sympathomimetics.
IsoprenalineMay enhance the adverse/toxic effect of other Sympathomimetics.
LabetalolMay enhance the adverse/toxic effect of other Sympathomimetics.
LevonordefrinMay enhance the adverse/toxic effect of other Sympathomimetics.
LinezolidMay enhance the hypertensive effect of Sympathomimetics.
LisdexamfetamineMay enhance the adverse/toxic effect of other Sympathomimetics.
LithiumMay diminish the stimulatory effect of Amphetamines.
LoxapineMay diminish the stimulatory effect of Amphetamines.
Magnesium oxideMay decrease the excretion of Amphetamines.
MephentermineMay enhance the adverse/toxic effect of other Sympathomimetics.
MesoridazineMay diminish the stimulatory effect of Amphetamines.
MetaraminolMay enhance the adverse/toxic effect of other Sympathomimetics.
MethamphetamineMay enhance the adverse/toxic effect of other Sympathomimetics.
MethotrimeprazineMay diminish the stimulatory effect of Amphetamines.
MethoxamineMay enhance the adverse/toxic effect of other Sympathomimetics.
MethylphenidateMay enhance the adverse/toxic effect of other Sympathomimetics.
MidodrineMay enhance the adverse/toxic effect of other Sympathomimetics.
ModafinilMay enhance the adverse/toxic effect of other Sympathomimetics.
MolindoneMay diminish the stimulatory effect of Amphetamines.
NabiloneCannabinoid-Containing Products may enhance the tachycardic effect of Sympathomimetics.
NaphazolineMay enhance the adverse/toxic effect of other Sympathomimetics.
NorepinephrineMay enhance the adverse/toxic effect of other Sympathomimetics.
OlanzapineMay diminish the stimulatory effect of Amphetamines.
OndansetronMay diminish the stimulatory effect of Amphetamines.
OrciprenalineMay enhance the adverse/toxic effect of other Sympathomimetics.
OxymetazolineMay enhance the adverse/toxic effect of other Sympathomimetics.
PaliperidoneMay diminish the stimulatory effect of Amphetamines.
PerphenazineMay diminish the stimulatory effect of Amphetamines.
PhendimetrazineMay enhance the adverse/toxic effect of other Sympathomimetics.
PheniramineMay enhance the adverse/toxic effect of other Sympathomimetics.
PhenmetrazineMay enhance the adverse/toxic effect of other Sympathomimetics.
PhenobarbitalAmphetamines may decrease the serum concentration of PHENobarbital.
PhenylephrineMay enhance the adverse/toxic effect of other Sympathomimetics.
PhenylpropanolamineMay enhance the adverse/toxic effect of other Sympathomimetics.
PhenytoinAmphetamines may decrease the serum concentration of Phenytoin.
PimozideMay diminish the stimulatory effect of Amphetamines.
PiperacetazineMay diminish the stimulatory effect of Amphetamines.
PirbuterolMay enhance the adverse/toxic effect of other Sympathomimetics.
ProchlorperazineMay diminish the stimulatory effect of Amphetamines.
PromazineMay diminish the stimulatory effect of Amphetamines.
PropylhexedrineMay enhance the adverse/toxic effect of other Sympathomimetics.
PseudoephedrineMay enhance the adverse/toxic effect of other Sympathomimetics.
QuetiapineMay diminish the stimulatory effect of Amphetamines.
RemoxiprideMay diminish the stimulatory effect of Amphetamines.
ReserpineMay diminish the stimulatory effect of Amphetamines.
RisperidoneMay diminish the stimulatory effect of Amphetamines.
RitodrineMay enhance the adverse/toxic effect of other Sympathomimetics.
SalbutamolMay enhance the adverse/toxic effect of other Sympathomimetics.
SalmeterolMay enhance the adverse/toxic effect of other Sympathomimetics.
SertindoleMay diminish the stimulatory effect of Amphetamines.
SulpirideMay diminish the stimulatory effect of Amphetamines.
Tedizolid PhosphateTedizolid may enhance the hypertensive effect of Sympathomimetics. Tedizolid may enhance the tachycardic effect of Sympathomimetics.
TerbutalineMay enhance the adverse/toxic effect of other Sympathomimetics.
TheophyllineMay enhance the adverse/toxic effect of other Sympathomimetics.
ThioridazineMay diminish the stimulatory effect of Amphetamines.
ThiothixeneMay diminish the stimulatory effect of Amphetamines.
TrifluoperazineMay diminish the stimulatory effect of Amphetamines.
TriflupromazineMay diminish the stimulatory effect of Amphetamines.
TriprolidineMay enhance the adverse/toxic effect of other Sympathomimetics.
Vitamin CMay decrease the serum concentration of Amphetamines.
ZiprasidoneMay diminish the stimulatory effect of Amphetamines.
ZuclopenthixolMay diminish the stimulatory effect of Amphetamines.
Food Interactions
  • Limit caffeine intake.
  • Take without regard to meals.

Targets

1. Sodium-dependent noradrenaline transporter

Kind: protein

Organism: Human

Pharmacological action: yes

Actions: inhibitor

Components

Name UniProt ID Details
Sodium-dependent noradrenaline transporter P23975 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Stephens LC, Katz SG: Phentermine and anaesthesia. Anaesth Intensive Care. 2005 Aug;33(4):525-7. Pubmed
  4. Samanin R, Garattini S: Neurochemical mechanism of action of anorectic drugs. Pharmacol Toxicol. 1993 Aug;73(2):63-8. Pubmed
  5. Proietto J, Fam BC, Ainslie DA, Thorburn AW: Novel anti-obesity drugs. Expert Opin Investig Drugs. 2000 Jun;9(6):1317-26. Pubmed

2. Sodium-dependent serotonin transporter

Kind: protein

Organism: Human

Pharmacological action: yes

Actions: inhibitor

Components

Name UniProt ID Details
Sodium-dependent serotonin transporter P31645 Details

References:

  1. John CE, Jones SR: Voltammetric characterization of the effect of monoamine uptake inhibitors and releasers on dopamine and serotonin uptake in mouse caudate-putamen and substantia nigra slices. Neuropharmacology. 2007 Jun;52(8):1596-605. Epub 2007 Mar 16. Pubmed
  2. Johnson GJ, Leis LA, Dunlop PC, Weir EK: The effect of the anorectic agent, d-fenfluramine, and its primary metabolite, d-norfenfluramine, on intact human platelet serotonin uptake and efflux. J Thromb Haemost. 2003 Dec;1(12):2663-8. Pubmed
  3. Mekontso-Dessap A, Brouri F, Pascal O, Lechat P, Hanoun N, Lanfumey L, Seif I, Benhaiem-Sigaux N, Kirsch M, Hamon M, Adnot S, Eddahibi S: Deficiency of the 5-hydroxytryptamine transporter gene leads to cardiac fibrosis and valvulopathy in mice. Circulation. 2006 Jan 3;113(1):81-9. Epub 2005 Dec 27. Pubmed
  4. Rothman RB, Ayestas MA, Dersch CM, Baumann MH: Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates. Implications for primary pulmonary hypertension. Circulation. 1999 Aug 24;100(8):869-75. Pubmed
  5. Zolkowska D, Rothman RB, Baumann MH: Amphetamine analogs increase plasma serotonin: implications for cardiac and pulmonary disease. J Pharmacol Exp Ther. 2006 Aug;318(2):604-10. Epub 2006 Apr 27. Pubmed

3. Sodium-dependent dopamine transporter

Kind: protein

Organism: Human

Pharmacological action: yes

Actions: inhibitor

Components

Name UniProt ID Details
Sodium-dependent dopamine transporter Q01959 Details

References:

  1. John CE, Jones SR: Voltammetric characterization of the effect of monoamine uptake inhibitors and releasers on dopamine and serotonin uptake in mouse caudate-putamen and substantia nigra slices. Neuropharmacology. 2007 Jun;52(8):1596-605. Epub 2007 Mar 16. Pubmed
  2. Gruner JA, Marcy VR, Lin YG, Bozyczko-Coyne D, Marino MJ, Gasior M: The roles of dopamine transport inhibition and dopamine release facilitation in wake enhancement and rebound hypersomnolence induced by dopaminergic agents. Sleep. 2009 Nov 1;32(11):1425-38. Pubmed

4. Amine oxidase [flavin-containing] A

Kind: protein

Organism: Human

Pharmacological action: yes

Actions: antagonist

Components

Name UniProt ID Details
Amine oxidase [flavin-containing] A P21397 Details

References:

  1. Rothman RB: Is phentermine an inhibitor of monoamine oxidase? A critical appraisal. Synapse. 1999 May;32(2):141-5. Pubmed
  2. Ulus IH, Maher TJ, Wurtman RJ: Characterization of phentermine and related compounds as monoamine oxidase (MAO) inhibitors. Biochem Pharmacol. 2000 Jun 15;59(12):1611-21. Pubmed
  3. Kilpatrick IC, Traut M, Heal DJ: Monoamine oxidase inhibition is unlikely to be relevant to the risks associated with phentermine and fenfluramine: a comparison with their abilities to evoke monoamine release. Int J Obes Relat Metab Disord. 2001 Oct;25(10):1454-8. Pubmed
  4. Nandigama RK, Newton-Vinson P, Edmondson DE: Phentermine inhibition of recombinant human liver monoamine oxidases A and B. Biochem Pharmacol. 2002 Mar 1;63(5):865-9. Pubmed

5. Amine oxidase [flavin-containing] B

Kind: protein

Organism: Human

Pharmacological action: yes

Actions: antagonist

Components

Name UniProt ID Details
Amine oxidase [flavin-containing] B P27338 Details

References:

  1. Rothman RB: Does phentermine inhibit monoamine oxidase? Lancet. 1999 Apr 17;353(9161):1362-3. Pubmed
  2. Rothman RB: Is phentermine an inhibitor of monoamine oxidase? A critical appraisal. Synapse. 1999 May;32(2):141-5. Pubmed
  3. Ulus IH, Maher TJ, Wurtman RJ: Characterization of phentermine and related compounds as monoamine oxidase (MAO) inhibitors. Biochem Pharmacol. 2000 Jun 15;59(12):1611-21. Pubmed
  4. Kilpatrick IC, Traut M, Heal DJ: Monoamine oxidase inhibition is unlikely to be relevant to the risks associated with phentermine and fenfluramine: a comparison with their abilities to evoke monoamine release. Int J Obes Relat Metab Disord. 2001 Oct;25(10):1454-8. Pubmed
  5. Nandigama RK, Newton-Vinson P, Edmondson DE: Phentermine inhibition of recombinant human liver monoamine oxidases A and B. Biochem Pharmacol. 2002 Mar 1;63(5):865-9. Pubmed

Enzymes

1. Amine oxidase [flavin-containing] A

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Amine oxidase [flavin-containing] A P21397 Details

References:

  1. Nandigama RK, Newton-Vinson P, Edmondson DE: Phentermine inhibition of recombinant human liver monoamine oxidases A and B. Biochem Pharmacol. 2002 Mar 1;63(5):865-9. Pubmed
  2. Ulus IH, Maher TJ, Wurtman RJ: Characterization of phentermine and related compounds as monoamine oxidase (MAO) inhibitors. Biochem Pharmacol. 2000 Jun 15;59(12):1611-21. Pubmed

2. Amine oxidase [flavin-containing] B

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Amine oxidase [flavin-containing] B P27338 Details

References:

  1. Nandigama RK, Newton-Vinson P, Edmondson DE: Phentermine inhibition of recombinant human liver monoamine oxidases A and B. Biochem Pharmacol. 2002 Mar 1;63(5):865-9. Pubmed
  2. Ulus IH, Maher TJ, Wurtman RJ: Characterization of phentermine and related compounds as monoamine oxidase (MAO) inhibitors. Biochem Pharmacol. 2000 Jun 15;59(12):1611-21. Pubmed

3. Cytochrome P450 1A2

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Cytochrome P450 1A2 P05177 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

4. Cytochrome P450 2C9

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor inducer

Components

Name UniProt ID Details
Cytochrome P450 2C9 P11712 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

5. Cytochrome P450 2D6

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Cytochrome P450 2D6 P10635 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

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Drug created on June 13, 2005 07:24 / Updated on September 16, 2013 17:08