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Identification
NameNelfinavir
Accession NumberDB00220  (APRD00003)
TypeSmall Molecule
GroupsApproved
DescriptionA potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. [PubChem]
Structure
Thumb
Synonyms
Viracept
External Identifiers
  • AG1343
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Viracepttablet, film coated625 mg/1oralREMEDYREPACK INC.2013-03-272016-03-11Us
Viracepttablet, film coated250 mg/1oralAGOURON1997-03-14Not applicableUs
Viracepttablet, film coated250 mg/1oralH.J. Harkins Company, Inc.1997-03-14Not applicableUs
Viraceptpowder50 mg/goralAGOURON1997-03-142016-02-26Us
Viracepttablet625 mgoralPfizer Canada Inc2004-08-11Not applicableCanada
Viracepttablet, film coated625 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Viracepttablet, film coated625 mg/1oralAGOURON2003-04-30Not applicableUs
Viracepttablet, film coated250 mg/1oralPd Rx Pharmaceuticals, Inc.1997-03-14Not applicableUs
Viracept -250mgtablet250 mgoralPfizer Canada Inc1998-09-21Not applicableCanada
Viracept -50mgpowder50 mgoralPfizer Canada Inc1998-09-21Not applicableCanada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Nelfinavir mesylate
ThumbNot applicableDBSALT000885
Categories
UNIIHO3OGH5D7I
CAS number159989-64-7
WeightAverage: 567.782
Monoisotopic: 567.313077633
Chemical FormulaC32H45N3O4S
InChI KeyInChIKey=QAGYKUNXZHXKMR-HKWSIXNMSA-N
InChI
InChI=1S/C32H45N3O4S/c1-21-25(15-10-16-28(21)36)30(38)33-26(20-40-24-13-6-5-7-14-24)29(37)19-35-18-23-12-9-8-11-22(23)17-27(35)31(39)34-32(2,3)4/h5-7,10,13-16,22-23,26-27,29,36-37H,8-9,11-12,17-20H2,1-4H3,(H,33,38)(H,34,39)/t22-,23+,26-,27-,29+/m0/s1
IUPAC Name
(3S,4aS,8aS)-N-tert-butyl-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylphenyl)formamido]-4-(phenylsulfanyl)butyl]-decahydroisoquinoline-3-carboxamide
SMILES
[H][C@@]12CCCC[C@]1([H])CN(C[C@@H](O)[[email protected]](CSC1=CC=CC=C1)NC(=O)C1=C(C)C(O)=CC=C1)[C@@H](C2)C(=O)NC(C)(C)C
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as alpha amino acid amides. These are amide derivatives of alpha amino acids.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentAlpha amino acid amides
Alternative Parents
Substituents
  • Alpha-amino acid amide
  • Piperidinecarboxylic acid
  • Piperidinecarboxamide
  • 2-piperidinecarboxamide
  • Benzoic acid or derivatives
  • Benzamide
  • Thiophenol ether
  • O-cresol
  • Benzoyl
  • Alkylarylthioether
  • Toluene
  • Phenol
  • Benzenoid
  • Piperidine
  • Monocyclic benzene moiety
  • Tertiary aliphatic amine
  • Tertiary amine
  • Secondary carboxylic acid amide
  • Secondary alcohol
  • Carboxamide group
  • 1,2-aminoalcohol
  • Azacycle
  • Organoheterocyclic compound
  • Sulfenyl compound
  • Thioether
  • Carboxylic acid amide
  • Hydrocarbon derivative
  • Organosulfur compound
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Alcohol
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationUsed in combination with other antiviral drugs in the treatment of HIV in both adults and children.
PharmacodynamicsNelfinavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease. HIV-1 protease is an enzyme required for the proteolytic cleavage of the viral polyprotein precursors into the individual functional proteins found in infectious HIV-1. Nelfinavir binds to the protease active site and inhibits the activity of the enzyme. This inhibition prevents cleavage of the viral polyproteins resulting in the formation of immature non-infectious viral particles. Protease inhibitors are almost always used in combination with at least two other anti-HIV drugs.
Mechanism of actionNelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles.
Related Articles
AbsorptionWell absorbed following oral administration.
Volume of distribution
  • 2 to 7 L/kg
Protein binding>98%
Metabolism

Primarily hepatic via cytochrome P450 (CYP450) enzymes. CYP3A and CYP2C19 appear to be the predominant enzymes that metabolize nelfinavir in humans. One major and several minor metabolites are found in plasma; the major oxidative metabolite has in vitro antiviral activity comparable to that of the parent drug.

Route of eliminationThe terminal half-life in plasma was typically 3.5 to 5 hours. The majority (87%) of an oral 750 mg dose containing 14C-nelfinavir was recovered in the feces; fecal radioactivity consisted of numerous oxidative metabolites (78%) and unchanged nelfinavir (22%). Only 1–2% of the dose was recovered in urine, of which unchanged nelfinavir was the major component.
Half life3.5 - 5 hours
ClearanceNot Available
ToxicityOral LD50 is over 5g/kg in rats. Side effects include thirst and hunger, unexplained weight loss, increased urination, fatigue, and dry, itchy skin.
Affected organisms
  • Human Immunodeficiency Virus
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.7472
Blood Brain Barrier-0.9659
Caco-2 permeable-0.7148
P-glycoprotein substrateSubstrate0.9332
P-glycoprotein inhibitor IInhibitor0.8121
P-glycoprotein inhibitor IIInhibitor0.7572
Renal organic cation transporterNon-inhibitor0.8178
CYP450 2C9 substrateNon-substrate0.7482
CYP450 2D6 substrateSubstrate0.8918
CYP450 3A4 substrateSubstrate0.7408
CYP450 1A2 substrateNon-inhibitor0.9085
CYP450 2C9 inhibitorNon-inhibitor0.7994
CYP450 2D6 inhibitorNon-inhibitor0.8071
CYP450 2C19 inhibitorNon-inhibitor0.6335
CYP450 3A4 inhibitorInhibitor0.5465
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8977
Ames testNon AMES toxic0.8008
CarcinogenicityNon-carcinogens0.8547
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.4704 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9786
hERG inhibition (predictor II)Inhibitor0.785
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Agouron pharmaceuticals inc
Packagers
Dosage forms
FormRouteStrength
Powderoral50 mg/g
Tabletoral625 mg
Tablet, film coatedoral250 mg/1
Tablet, film coatedoral625 mg/1
Tabletoral250 mg
Powderoral50 mg
Prices
Unit descriptionCostUnit
Viracept 625 mg tablet11.24USD tablet
Viracept 250 mg tablet3.46USD tablet
Viracept 50 mg/gm Powder0.54USD gm
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2173328 No1999-08-312014-10-07Canada
US5484926 No1994-04-072014-04-07Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point349.84 °CNot Available
water solubilitySlightly solubleNot Available
logP6Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00191 mg/mLALOGPS
logP4.61ALOGPS
logP4.72ChemAxon
logS-5.5ALOGPS
pKa (Strongest Acidic)9.32ChemAxon
pKa (Strongest Basic)8.18ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area101.9 Å2ChemAxon
Rotatable Bond Count10ChemAxon
Refractivity162.67 m3·mol-1ChemAxon
Polarizability63.8 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

DrugSyn.org

US5461154
General References
  1. Kaldor SW, Kalish VJ, Davies JF 2nd, Shetty BV, Fritz JE, Appelt K, Burgess JA, Campanale KM, Chirgadze NY, Clawson DK, Dressman BA, Hatch SD, Khalil DA, Kosa MB, Lubbehusen PP, Muesing MA, Patick AK, Reich SH, Su KS, Tatlock JH: Viracept (nelfinavir mesylate, AG1343): a potent, orally bioavailable inhibitor of HIV-1 protease. J Med Chem. 1997 Nov 21;40(24):3979-85. [PubMed:9397180 ]
External Links
ATC CodesJ05AE04
AHFS Codes
  • 08:18.08.08
PDB Entries
FDA labelDownload (294 KB)
MSDSDownload (56.6 KB)
Interactions
Drug Interactions
Drug
4-AndrostenedioneThe serum concentration of 4-Androstenedione can be increased when it is combined with Nelfinavir.
AbacavirThe serum concentration of Abacavir can be decreased when it is combined with Nelfinavir.
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Nelfinavir.
AcarboseThe therapeutic efficacy of Acarbose can be decreased when used in combination with Nelfinavir.
AcebutololThe serum concentration of Acebutolol can be decreased when it is combined with Nelfinavir.
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Nelfinavir.
AcetaminophenThe serum concentration of Acetaminophen can be decreased when it is combined with Nelfinavir.
AcetaminophenThe serum concentration of Nelfinavir can be increased when it is combined with Acetaminophen.
AcetohexamideThe therapeutic efficacy of Acetohexamide can be decreased when used in combination with Nelfinavir.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be decreased when it is combined with Nelfinavir.
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Nelfinavir.
AfatinibThe serum concentration of Afatinib can be decreased when it is combined with Nelfinavir.
AfatinibThe serum concentration of Nelfinavir can be increased when it is combined with Afatinib.
AicarThe therapeutic efficacy of Aicar can be decreased when used in combination with Nelfinavir.
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Nelfinavir.
AlbendazoleThe serum concentration of Nelfinavir can be increased when it is combined with Albendazole.
AlclometasoneThe serum concentration of Alclometasone can be increased when it is combined with Nelfinavir.
AldosteroneThe serum concentration of Aldosterone can be decreased when it is combined with Nelfinavir.
AlectinibThe serum concentration of Nelfinavir can be increased when it is combined with Alectinib.
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Nelfinavir.
AlfentanilThe serum concentration of Nelfinavir can be increased when it is combined with Alfentanil.
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Nelfinavir.
AliskirenThe metabolism of Aliskiren can be decreased when combined with Nelfinavir.
AlitretinoinThe serum concentration of Alitretinoin can be decreased when it is combined with Nelfinavir.
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Nelfinavir.
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Nelfinavir.
AlogliptinThe therapeutic efficacy of Alogliptin can be decreased when used in combination with Nelfinavir.
AlosetronThe serum concentration of Alosetron can be increased when it is combined with Nelfinavir.
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Nelfinavir.
AmantadineThe serum concentration of Nelfinavir can be increased when it is combined with Amantadine.
AmbrisentanThe serum concentration of Ambrisentan can be decreased when it is combined with Nelfinavir.
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Nelfinavir.
AmcinonideThe serum concentration of Amcinonide can be increased when it is combined with Nelfinavir.
AmineptineThe serum concentration of Amineptine can be increased when it is combined with Nelfinavir.
Aminohippuric acidThe serum concentration of Nelfinavir can be increased when it is combined with Aminohippuric acid.
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Nelfinavir.
AminophyllineThe serum concentration of Aminophylline can be decreased when it is combined with Nelfinavir.
AmiodaroneThe serum concentration of Amiodarone can be increased when it is combined with Nelfinavir.
AmiodaroneThe serum concentration of Nelfinavir can be decreased when it is combined with Amiodarone.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Nelfinavir.
AmlodipineThe metabolism of Amlodipine can be decreased when combined with Nelfinavir.
AmlodipineThe serum concentration of Nelfinavir can be increased when it is combined with Amlodipine.
AmoxicillinThe metabolism of Amoxicillin can be decreased when combined with Nelfinavir.
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Nelfinavir.
AmprenavirThe serum concentration of Nelfinavir can be decreased when it is combined with Amprenavir.
AmsacrineThe serum concentration of Nelfinavir can be increased when it is combined with Amsacrine.
AnagrelideNelfinavir may increase the QTc-prolonging activities of Anagrelide.
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Nelfinavir.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Nelfinavir.
ApremilastThe metabolism of Apremilast can be decreased when combined with Nelfinavir.
AprepitantThe serum concentration of Nelfinavir can be increased when it is combined with Aprepitant.
AprepitantThe metabolism of Aprepitant can be decreased when combined with Nelfinavir.
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Nelfinavir.
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Nelfinavir.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Nelfinavir.
ArmodafinilThe metabolism of Nelfinavir can be decreased when combined with Armodafinil.
Arsenic trioxideThe serum concentration of Arsenic trioxide can be decreased when it is combined with Nelfinavir.
ArtemetherThe metabolism of Artemether can be decreased when combined with Nelfinavir.
AsenapineThe serum concentration of Nelfinavir can be decreased when it is combined with Asenapine.
AsenapineThe metabolism of Asenapine can be decreased when combined with Nelfinavir.
AstemizoleThe serum concentration of Astemizole can be increased when it is combined with Nelfinavir.
AtazanavirThe serum concentration of Atazanavir can be decreased when it is combined with Nelfinavir.
AtazanavirThe serum concentration of Nelfinavir can be increased when it is combined with Atazanavir.
AtenololThe serum concentration of Atenolol can be decreased when it is combined with Nelfinavir.
AtenololThe serum concentration of Nelfinavir can be increased when it is combined with Atenolol.
AtomoxetineThe metabolism of Nelfinavir can be decreased when combined with Atomoxetine.
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Nelfinavir.
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Nelfinavir.
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Nelfinavir.
AzelastineThe serum concentration of Nelfinavir can be increased when it is combined with Azelastine.
AzelastineThe metabolism of Azelastine can be decreased when combined with Nelfinavir.
AzithromycinThe serum concentration of Azithromycin can be increased when it is combined with Nelfinavir.
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Nelfinavir.
BarnidipineThe serum concentration of Barnidipine can be increased when it is combined with Nelfinavir.
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be increased when it is combined with Nelfinavir.
BedaquilineNelfinavir may increase the QTc-prolonging activities of Bedaquiline.
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Nelfinavir.
BenzocaineThe serum concentration of Nelfinavir can be increased when it is combined with Benzocaine.
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Nelfinavir.
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Nelfinavir.
BepridilThe serum concentration of Nelfinavir can be increased when it is combined with Bepridil.
BetamethasoneThe serum concentration of Betamethasone can be decreased when it is combined with Nelfinavir.
BexaroteneThe serum concentration of Nelfinavir can be decreased when it is combined with Bexarotene.
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Nelfinavir.
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Nelfinavir.
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Nelfinavir.
BiperidenThe serum concentration of Nelfinavir can be increased when it is combined with Biperiden.
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Nelfinavir.
BoceprevirThe serum concentration of Nelfinavir can be decreased when it is combined with Boceprevir.
BortezomibThe serum concentration of Bortezomib can be increased when it is combined with Nelfinavir.
BortezomibThe metabolism of Nelfinavir can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Nelfinavir can be decreased when it is combined with Bosentan.
BosentanThe serum concentration of Bosentan can be increased when it is combined with Nelfinavir.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Nelfinavir.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Nelfinavir.
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Nelfinavir.
BrinzolamideThe serum concentration of Brinzolamide can be increased when it is combined with Nelfinavir.
BromazepamThe metabolism of Bromazepam can be decreased when combined with Nelfinavir.
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Nelfinavir.
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Nelfinavir.
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Nelfinavir.
BuforminThe therapeutic efficacy of Buformin can be decreased when used in combination with Nelfinavir.
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Nelfinavir.
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Nelfinavir.
BuprenorphineThe serum concentration of Nelfinavir can be increased when it is combined with Buprenorphine.
BupropionThe metabolism of Bupropion can be decreased when combined with Nelfinavir.
BuspironeThe metabolism of Buspirone can be decreased when combined with Nelfinavir.
BuspironeThe serum concentration of Nelfinavir can be increased when it is combined with Buspirone.
BusulfanThe metabolism of Busulfan can be decreased when combined with Nelfinavir.
CabazitaxelThe serum concentration of Cabazitaxel can be decreased when it is combined with Nelfinavir.
CabazitaxelThe serum concentration of Nelfinavir can be increased when it is combined with Cabazitaxel.
CabergolineThe serum concentration of Cabergoline can be increased when it is combined with Nelfinavir.
CabozantinibThe serum concentration of Cabozantinib can be increased when it is combined with Nelfinavir.
CaffeineThe serum concentration of Caffeine can be decreased when it is combined with Nelfinavir.
CaffeineThe serum concentration of Nelfinavir can be increased when it is combined with Caffeine.
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Nelfinavir.
CamptothecinThe serum concentration of Camptothecin can be decreased when it is combined with Nelfinavir.
CanagliflozinThe therapeutic efficacy of Canagliflozin can be decreased when used in combination with Nelfinavir.
CanagliflozinThe serum concentration of Nelfinavir can be increased when it is combined with Canagliflozin.
CandesartanThe serum concentration of Nelfinavir can be increased when it is combined with Candesartan.
CaptoprilThe serum concentration of Nelfinavir can be increased when it is combined with Captopril.
CarbamazepineThe serum concentration of Carbamazepine can be decreased when it is combined with Nelfinavir.
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Nelfinavir.
CarfilzomibThe serum concentration of Carfilzomib can be decreased when it is combined with Nelfinavir.
CariprazineThe metabolism of Cariprazine can be decreased when combined with Nelfinavir.
CarisoprodolThe metabolism of Carisoprodol can be decreased when combined with Nelfinavir.
CarvedilolThe metabolism of Carvedilol can be decreased when combined with Nelfinavir.
CarvedilolThe serum concentration of Nelfinavir can be increased when it is combined with Carvedilol.
CaspofunginThe serum concentration of Nelfinavir can be increased when it is combined with Caspofungin.
CastanospermineThe therapeutic efficacy of Castanospermine can be decreased when used in combination with Nelfinavir.
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Nelfinavir.
CeliprololThe metabolism of Celiprolol can be decreased when combined with Nelfinavir.
CephalexinThe metabolism of Cephalexin can be decreased when combined with Nelfinavir.
CeritinibThe serum concentration of Nelfinavir can be increased when it is combined with Ceritinib.
CerivastatinThe serum concentration of Cerivastatin can be decreased when it is combined with Nelfinavir.
CevimelineThe metabolism of Cevimeline can be decreased when combined with Nelfinavir.
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Nelfinavir.
ChloramphenicolThe metabolism of Nelfinavir can be decreased when combined with Chloramphenicol.
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Nelfinavir.
ChloroquineNelfinavir may increase the QTc-prolonging activities of Chloroquine.
ChloroquineThe serum concentration of Nelfinavir can be increased when it is combined with Chloroquine.
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Nelfinavir.
ChlorpromazineNelfinavir may increase the QTc-prolonging activities of Chlorpromazine.
ChlorpromazineThe serum concentration of Nelfinavir can be increased when it is combined with Chlorpromazine.
ChlorpropamideThe therapeutic efficacy of Chlorpropamide can be decreased when used in combination with Nelfinavir.
ChlorpropamideThe serum concentration of Nelfinavir can be increased when it is combined with Chlorpropamide.
ChlorprothixeneThe serum concentration of Nelfinavir can be increased when it is combined with Chlorprothixene.
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Nelfinavir.
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Nelfinavir.
CholesterolThe serum concentration of Nelfinavir can be increased when it is combined with Cholesterol.
Cholic AcidThe serum concentration of Nelfinavir can be decreased when it is combined with Cholic Acid.
CiclesonideThe serum concentration of Ciclesonide can be increased when it is combined with Nelfinavir.
CiglitazoneThe therapeutic efficacy of Ciglitazone can be decreased when used in combination with Nelfinavir.
CilazaprilThe serum concentration of Nelfinavir can be increased when it is combined with Cilazapril.
CilostazolThe metabolism of Cilostazol can be decreased when combined with Nelfinavir.
CimetidineThe serum concentration of Nelfinavir can be decreased when it is combined with Cimetidine.
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Nelfinavir.
CiprofloxacinNelfinavir may increase the QTc-prolonging activities of Ciprofloxacin.
CiprofloxacinThe serum concentration of Nelfinavir can be increased when it is combined with Ciprofloxacin.
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Nelfinavir.
CisplatinThe serum concentration of Cisplatin can be decreased when it is combined with Nelfinavir.
CitalopramThe serum concentration of Citalopram can be decreased when it is combined with Nelfinavir.
CitalopramThe serum concentration of Nelfinavir can be increased when it is combined with Citalopram.
ClarithromycinNelfinavir may increase the QTc-prolonging activities of Clarithromycin.
ClarithromycinThe serum concentration of Nelfinavir can be increased when it is combined with Clarithromycin.
ClemastineThe metabolism of Nelfinavir can be decreased when combined with Clemastine.
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Nelfinavir.
ClobazamThe serum concentration of Clobazam can be decreased when it is combined with Nelfinavir.
Clobetasol propionateThe serum concentration of Clobetasol propionate can be increased when it is combined with Nelfinavir.
ClocortoloneThe serum concentration of Clocortolone can be increased when it is combined with Nelfinavir.
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Nelfinavir.
ClofazimineThe serum concentration of Nelfinavir can be increased when it is combined with Clofazimine.
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Nelfinavir.
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Nelfinavir.
ClomifeneThe serum concentration of Clomifene can be decreased when it is combined with Nelfinavir.
ClomipramineThe serum concentration of Clomipramine can be increased when it is combined with Nelfinavir.
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Nelfinavir.
ClonidineThe serum concentration of Clonidine can be decreased when it is combined with Nelfinavir.
ClopidogrelThe serum concentration of Clopidogrel can be decreased when it is combined with Nelfinavir.
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Nelfinavir.
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Nelfinavir.
ClotrimazoleThe metabolism of Nelfinavir can be decreased when combined with Clotrimazole.
ClozapineNelfinavir may increase the QTc-prolonging activities of Clozapine.
CobicistatThe serum concentration of Nelfinavir can be increased when it is combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Nelfinavir.
CocaineThe metabolism of Cocaine can be decreased when combined with Nelfinavir.
CodeineThe metabolism of Codeine can be decreased when combined with Nelfinavir.
ColchicineThe serum concentration of Colchicine can be decreased when it is combined with Nelfinavir.
ColchicineThe serum concentration of Nelfinavir can be increased when it is combined with Colchicine.
ColforsinThe serum concentration of Nelfinavir can be increased when it is combined with Colforsin.
ConivaptanThe serum concentration of Nelfinavir can be increased when it is combined with Conivaptan.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be decreased when it is combined with Nelfinavir.
Cortisone acetateThe serum concentration of Cortisone acetate can be increased when it is combined with Nelfinavir.
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Nelfinavir.
CrizotinibThe metabolism of Nelfinavir can be decreased when combined with Crizotinib.
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be increased when it is combined with Nelfinavir.
CyclophosphamideThe risk or severity of adverse effects can be increased when Nelfinavir is combined with Cyclophosphamide.
CyclophosphamideThe serum concentration of Nelfinavir can be increased when it is combined with Cyclophosphamide.
CyclosporineThe metabolism of Nelfinavir can be decreased when combined with Cyclosporine.
CyclosporineThe serum concentration of Cyclosporine can be decreased when it is combined with Nelfinavir.
CytarabineThe metabolism of Cytarabine can be decreased when combined with Nelfinavir.
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be decreased when it is combined with Nelfinavir.
DabrafenibThe serum concentration of Nelfinavir can be decreased when it is combined with Dabrafenib.
DaclatasvirThe serum concentration of Daclatasvir can be increased when it is combined with Nelfinavir.
DactinomycinThe serum concentration of Dactinomycin can be decreased when it is combined with Nelfinavir.
DactinomycinThe serum concentration of Nelfinavir can be increased when it is combined with Dactinomycin.
DantroleneThe metabolism of Dantrolene can be decreased when combined with Nelfinavir.
DapagliflozinThe serum concentration of Dapagliflozin can be decreased when it is combined with Nelfinavir.
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Nelfinavir.
DapsoneThe metabolism of Dapsone can be decreased when combined with Nelfinavir.
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Nelfinavir.
DarunavirThe metabolism of Darunavir can be decreased when combined with Nelfinavir.
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Nelfinavir.
DasatinibThe serum concentration of Nelfinavir can be increased when it is combined with Dasatinib.
DasatinibThe serum concentration of Dasatinib can be decreased when it is combined with Nelfinavir.
DaunorubicinThe serum concentration of Daunorubicin can be decreased when it is combined with Nelfinavir.
DebrisoquinThe serum concentration of Debrisoquin can be decreased when it is combined with Nelfinavir.
DeferasiroxThe serum concentration of Nelfinavir can be decreased when it is combined with Deferasirox.
DehydroepiandrosteroneThe serum concentration of Dehydroepiandrosterone can be increased when it is combined with Nelfinavir.
dehydroepiandrosterone sulfateThe serum concentration of dehydroepiandrosterone sulfate can be increased when it is combined with Nelfinavir.
DelavirdineThe serum concentration of Delavirdine can be decreased when it is combined with Nelfinavir.
DelavirdineThe metabolism of Nelfinavir can be decreased when combined with Delavirdine.
DesipramineThe serum concentration of Desipramine can be increased when it is combined with Nelfinavir.
DesloratadineThe serum concentration of Nelfinavir can be increased when it is combined with Desloratadine.
DesoximetasoneThe serum concentration of Desoximetasone can be increased when it is combined with Nelfinavir.
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be increased when it is combined with Nelfinavir.
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Nelfinavir.
DexamethasoneThe serum concentration of Nelfinavir can be decreased when it is combined with Dexamethasone.
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be increased when it is combined with Nelfinavir.
DextromethorphanThe serum concentration of Nelfinavir can be increased when it is combined with Dextromethorphan.
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Nelfinavir.
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Nelfinavir.
DiazepamThe serum concentration of Diazepam can be decreased when it is combined with Nelfinavir.
DiclofenacThe serum concentration of Nelfinavir can be increased when it is combined with Diclofenac.
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Nelfinavir.
DienogestThe serum concentration of Dienogest can be increased when it is combined with Nelfinavir.
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be decreased when it is combined with Nelfinavir.
DiflorasoneThe serum concentration of Diflorasone can be increased when it is combined with Nelfinavir.
DifluocortoloneThe serum concentration of Difluocortolone can be increased when it is combined with Nelfinavir.
DifluprednateThe serum concentration of Difluprednate can be increased when it is combined with Nelfinavir.
DigitoxinThe serum concentration of Digitoxin can be decreased when it is combined with Nelfinavir.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Nelfinavir.
DigoxinThe serum concentration of Nelfinavir can be decreased when it is combined with Digoxin.
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Nelfinavir.
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Nelfinavir.
DihydroergotamineThe metabolism of Nelfinavir can be decreased when combined with Dihydroergotamine.
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Nelfinavir.
DiltiazemThe metabolism of Nelfinavir can be decreased when combined with Diltiazem.
DiltiazemThe serum concentration of Diltiazem can be decreased when it is combined with Nelfinavir.
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Nelfinavir.
DipyridamoleThe serum concentration of Dipyridamole can be decreased when it is combined with Nelfinavir.
DipyridamoleThe serum concentration of Nelfinavir can be increased when it is combined with Dipyridamole.
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Nelfinavir.
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Nelfinavir.
DocetaxelThe serum concentration of Docetaxel can be decreased when it is combined with Nelfinavir.
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Nelfinavir.
DolasetronNelfinavir may increase the QTc-prolonging activities of Dolasetron.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Nelfinavir.
DonepezilThe metabolism of Donepezil can be decreased when combined with Nelfinavir.
DopamineThe metabolism of Dopamine can be decreased when combined with Nelfinavir.
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Nelfinavir.
DosulepinThe serum concentration of Dosulepin can be increased when it is combined with Nelfinavir.
DoxazosinThe serum concentration of Nelfinavir can be increased when it is combined with Doxazosin.
DoxazosinThe metabolism of Doxazosin can be decreased when combined with Nelfinavir.
DoxepinThe serum concentration of Nelfinavir can be decreased when it is combined with Doxepin.
DoxepinThe serum concentration of Doxepin can be increased when it is combined with Nelfinavir.
DoxorubicinThe serum concentration of Doxorubicin can be decreased when it is combined with Nelfinavir.
DoxycyclineThe metabolism of Nelfinavir can be decreased when combined with Doxycycline.
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Nelfinavir.
DronedaroneThe serum concentration of Dronedarone can be increased when it is combined with Nelfinavir.
DronedaroneThe metabolism of Nelfinavir can be decreased when combined with Dronedarone.
DroperidolNelfinavir may increase the QTc-prolonging activities of Droperidol.
DrospirenoneThe serum concentration of Drospirenone can be increased when it is combined with Nelfinavir.
DulaglutideThe therapeutic efficacy of Dulaglutide can be decreased when used in combination with Nelfinavir.
DutasterideThe serum concentration of Dutasteride can be increased when it is combined with Nelfinavir.
DyphyllineThe serum concentration of Dyphylline can be decreased when it is combined with Nelfinavir.
EdoxabanThe serum concentration of Edoxaban can be decreased when it is combined with Nelfinavir.
EfavirenzThe serum concentration of Nelfinavir can be decreased when it is combined with Efavirenz.
EfavirenzThe metabolism of Efavirenz can be decreased when combined with Nelfinavir.
ElbasvirThe serum concentration of Nelfinavir can be increased when it is combined with Elbasvir.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Nelfinavir.
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Nelfinavir.
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Nelfinavir.
EmpagliflozinThe therapeutic efficacy of Empagliflozin can be decreased when used in combination with Nelfinavir.
EnalaprilThe metabolism of Enalapril can be decreased when combined with Nelfinavir.
EnalaprilThe serum concentration of Nelfinavir can be increased when it is combined with Enalapril.
EnfuvirtideThe serum concentration of Enfuvirtide can be increased when it is combined with Nelfinavir.
EnzalutamideThe serum concentration of Enzalutamide can be increased when it is combined with Nelfinavir.
EpinastineThe serum concentration of Nelfinavir can be decreased when it is combined with Epinastine.
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Nelfinavir.
EquileninThe serum concentration of Equilenin can be increased when it is combined with Nelfinavir.
EquilinThe serum concentration of Equilin can be increased when it is combined with Nelfinavir.
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Nelfinavir.
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Nelfinavir.
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Nelfinavir.
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Nelfinavir.
ErlotinibThe serum concentration of Erlotinib can be decreased when it is combined with Nelfinavir.
ErythromycinNelfinavir may increase the QTc-prolonging activities of Erythromycin.
ErythromycinThe metabolism of Nelfinavir can be decreased when combined with Erythromycin.
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Nelfinavir.
Eslicarbazepine acetateThe serum concentration of Nelfinavir can be decreased when it is combined with Eslicarbazepine acetate.
EsmirtazapineThe serum concentration of Esmirtazapine can be increased when it is combined with Nelfinavir.
EsomeprazoleThe serum concentration of the active metabolites of Nelfinavir can be reduced when Nelfinavir is used in combination with Esomeprazole resulting in a loss in efficacy.
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Nelfinavir.
EstazolamThe serum concentration of Estazolam can be increased when it is combined with Nelfinavir.
EstradiolThe serum concentration of Estradiol can be decreased when it is combined with Nelfinavir.
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Nelfinavir.
EstramustineThe metabolism of Estramustine can be decreased when combined with Nelfinavir.
EstramustineThe serum concentration of Nelfinavir can be increased when it is combined with Estramustine.
EstriolThe serum concentration of Estriol can be decreased when it is combined with Nelfinavir.
EstroneThe serum concentration of Estrone can be decreased when it is combined with Nelfinavir.
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Nelfinavir.
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Nelfinavir.
EthanolThe metabolism of Ethanol can be decreased when combined with Nelfinavir.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Nelfinavir.
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Nelfinavir.
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Nelfinavir.
EtizolamThe serum concentration of Etizolam can be increased when it is combined with Nelfinavir.
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Nelfinavir.
EtoposideThe serum concentration of Etoposide can be decreased when it is combined with Nelfinavir.
EtoposideThe serum concentration of Nelfinavir can be increased when it is combined with Etoposide.
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Nelfinavir.
EtravirineThe serum concentration of Etravirine can be decreased when it is combined with Nelfinavir.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Nelfinavir.
ExemestaneThe metabolism of Exemestane can be decreased when combined with Nelfinavir.
ExenatideThe therapeutic efficacy of Exenatide can be decreased when used in combination with Nelfinavir.
EzetimibeThe serum concentration of Ezetimibe can be decreased when it is combined with Nelfinavir.
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Nelfinavir.
FamotidineThe serum concentration of Nelfinavir can be decreased when it is combined with Famotidine.
FamotidineThe metabolism of Famotidine can be decreased when combined with Nelfinavir.
FelbamateThe metabolism of Felbamate can be decreased when combined with Nelfinavir.
FelodipineThe metabolism of Felodipine can be decreased when combined with Nelfinavir.
FelodipineThe serum concentration of Nelfinavir can be increased when it is combined with Felodipine.
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Nelfinavir.
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Nelfinavir.
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Nelfinavir.
FexofenadineThe serum concentration of Fexofenadine can be decreased when it is combined with Nelfinavir.
FexofenadineThe serum concentration of Nelfinavir can be increased when it is combined with Fexofenadine.
FidaxomicinThe serum concentration of Fidaxomicin can be decreased when it is combined with Nelfinavir.
FidaxomicinThe serum concentration of Nelfinavir can be increased when it is combined with Fidaxomicin.
FinasterideThe metabolism of Finasteride can be decreased when combined with Nelfinavir.
FingolimodThe metabolism of Fingolimod can be decreased when combined with Nelfinavir.
FlecainideNelfinavir may increase the QTc-prolonging activities of Flecainide.
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Nelfinavir.
FluconazoleThe metabolism of Nelfinavir can be decreased when combined with Fluconazole.
FludrocortisoneThe serum concentration of Fludrocortisone can be increased when it is combined with Nelfinavir.
FlumethasoneThe serum concentration of Flumethasone can be increased when it is combined with Nelfinavir.
FlunisolideThe serum concentration of Flunisolide can be increased when it is combined with Nelfinavir.
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Nelfinavir.
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be increased when it is combined with Nelfinavir.
FluocinonideThe serum concentration of Fluocinonide can be increased when it is combined with Nelfinavir.
FluocortoloneThe serum concentration of Fluocortolone can be increased when it is combined with Nelfinavir.
FluorometholoneThe serum concentration of Fluorometholone can be increased when it is combined with Nelfinavir.
FluoxetineThe serum concentration of Nelfinavir can be increased when it is combined with Fluoxetine.
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Nelfinavir.
FlupentixolThe serum concentration of Nelfinavir can be increased when it is combined with Flupentixol.
FlupentixolNelfinavir may increase the QTc-prolonging activities of Flupentixol.
FluphenazineThe serum concentration of Nelfinavir can be increased when it is combined with Fluphenazine.
FluprednideneThe serum concentration of Fluprednidene can be increased when it is combined with Nelfinavir.
FluprednisoloneThe serum concentration of Fluprednisolone can be increased when it is combined with Nelfinavir.
FlurandrenolideThe serum concentration of Flurandrenolide can be increased when it is combined with Nelfinavir.
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Nelfinavir.
FlurazepamThe serum concentration of Nelfinavir can be increased when it is combined with Flurazepam.
FlutamideThe metabolism of Flutamide can be decreased when combined with Nelfinavir.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be decreased when it is combined with Nelfinavir.
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be increased when it is combined with Nelfinavir.
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Nelfinavir.
FluvoxamineThe metabolism of Nelfinavir can be decreased when combined with Fluvoxamine.
FormoterolThe metabolism of Formoterol can be decreased when combined with Nelfinavir.
FosamprenavirThe metabolism of Nelfinavir can be decreased when combined with Fosamprenavir.
FosaprepitantThe serum concentration of Nelfinavir can be increased when it is combined with Fosaprepitant.
FosphenytoinThe serum concentration of Nelfinavir can be decreased when it is combined with Fosphenytoin.
FosphenytoinThe metabolism of Fosphenytoin can be decreased when combined with Nelfinavir.
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Nelfinavir.
Fusidic AcidThe serum concentration of Nelfinavir can be increased when it is combined with Fusidic Acid.
Gadobenic acidNelfinavir may increase the QTc-prolonging activities of Gadobenic acid.
GalantamineThe metabolism of Galantamine can be decreased when combined with Nelfinavir.
GarlicThe serum concentration of Nelfinavir can be decreased when it is combined with Garlic.
GefitinibThe serum concentration of Gefitinib can be decreased when it is combined with Nelfinavir.
GefitinibThe serum concentration of Nelfinavir can be increased when it is combined with Gefitinib.
GemcitabineThe serum concentration of Gemcitabine can be decreased when it is combined with Nelfinavir.
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Nelfinavir.
GemifloxacinNelfinavir may increase the QTc-prolonging activities of Gemifloxacin.
GenisteinThe serum concentration of Nelfinavir can be increased when it is combined with Genistein.
GlibornurideThe therapeutic efficacy of Glibornuride can be decreased when used in combination with Nelfinavir.
GliclazideThe therapeutic efficacy of Gliclazide can be decreased when used in combination with Nelfinavir.
GlimepirideThe therapeutic efficacy of Glimepiride can be decreased when used in combination with Nelfinavir.
GlipizideThe therapeutic efficacy of Glipizide can be decreased when used in combination with Nelfinavir.
GliquidoneThe therapeutic efficacy of Gliquidone can be decreased when used in combination with Nelfinavir.
GlucosamineThe metabolism of Glucosamine can be decreased when combined with Nelfinavir.
GlyburideThe therapeutic efficacy of Glyburide can be decreased when used in combination with Nelfinavir.
GlyburideThe serum concentration of Nelfinavir can be increased when it is combined with Glyburide.
GlycerolThe serum concentration of Nelfinavir can be increased when it is combined with Glycerol.
GoserelinNelfinavir may increase the QTc-prolonging activities of Goserelin.
Gramicidin DThe serum concentration of Nelfinavir can be increased when it is combined with Gramicidin D.
GranisetronNelfinavir may increase the QTc-prolonging activities of Granisetron.
GrazoprevirThe serum concentration of Grazoprevir can be decreased when it is combined with Nelfinavir.
GrepafloxacinThe serum concentration of Grepafloxacin can be decreased when it is combined with Nelfinavir.
GrepafloxacinThe serum concentration of Nelfinavir can be increased when it is combined with Grepafloxacin.
GuanfacineThe metabolism of Guanfacine can be decreased when combined with Nelfinavir.
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Nelfinavir.
HaloperidolNelfinavir may increase the QTc-prolonging activities of Haloperidol.
HaloperidolThe serum concentration of Nelfinavir can be increased when it is combined with Haloperidol.
HalothaneThe metabolism of Halothane can be decreased when combined with Nelfinavir.
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Nelfinavir.
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Nelfinavir.
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Nelfinavir.
HydrocortisoneThe serum concentration of Hydrocortisone can be decreased when it is combined with Nelfinavir.
HydrocortisoneThe serum concentration of Nelfinavir can be increased when it is combined with Hydrocortisone.
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Nelfinavir.
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Nelfinavir.
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Nelfinavir.
IbuprofenThe serum concentration of Ibuprofen can be decreased when it is combined with Nelfinavir.
IbutilideNelfinavir may increase the QTc-prolonging activities of Ibutilide.
IdelalisibThe serum concentration of Nelfinavir can be increased when it is combined with Idelalisib.
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Nelfinavir resulting in a loss in efficacy.
IloperidoneThe serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with Nelfinavir.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Nelfinavir.
ImatinibThe metabolism of Nelfinavir can be decreased when combined with Imatinib.
ImidafenacinThe serum concentration of Imidafenacin can be increased when it is combined with Nelfinavir.
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Nelfinavir.
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Nelfinavir.
IndacaterolThe serum concentration of Indacaterol can be decreased when it is combined with Nelfinavir.
IndapamideThe metabolism of Indapamide can be decreased when combined with Nelfinavir.
IndinavirThe serum concentration of Indinavir can be decreased when it is combined with Nelfinavir.
IndomethacinThe serum concentration of Indomethacin can be decreased when it is combined with Nelfinavir.
IndomethacinThe serum concentration of Nelfinavir can be increased when it is combined with Indomethacin.
Insulin AspartThe therapeutic efficacy of Insulin Aspart can be decreased when used in combination with Nelfinavir.
Insulin DetemirThe therapeutic efficacy of Insulin Detemir can be decreased when used in combination with Nelfinavir.
Insulin GlargineThe therapeutic efficacy of Insulin Glargine can be decreased when used in combination with Nelfinavir.
Insulin GlulisineThe therapeutic efficacy of Insulin Glulisine can be decreased when used in combination with Nelfinavir.
Insulin LisproThe therapeutic efficacy of Insulin Lispro can be decreased when used in combination with Nelfinavir.
Insulin PorkThe therapeutic efficacy of Insulin Pork can be decreased when used in combination with Nelfinavir.
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Nelfinavir.
IrinotecanThe serum concentration of the active metabolites of Irinotecan can be increased when Irinotecan is used in combination with Nelfinavir.
IsavuconazoniumThe serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Nelfinavir.
IsavuconazoniumThe metabolism of Nelfinavir can be decreased when combined with Isavuconazonium.
IsoniazidThe metabolism of Nelfinavir can be decreased when combined with Isoniazid.
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Nelfinavir.
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Nelfinavir.
IsradipineThe metabolism of Nelfinavir can be decreased when combined with Isradipine.
ItraconazoleThe metabolism of Itraconazole can be decreased when combined with Nelfinavir.
ItraconazoleThe serum concentration of Nelfinavir can be increased when it is combined with Itraconazole.
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Nelfinavir.
IvacaftorThe serum concentration of Nelfinavir can be increased when it is combined with Ivacaftor.
IvermectinThe serum concentration of Ivermectin can be decreased when it is combined with Nelfinavir.
IvermectinThe serum concentration of Nelfinavir can be increased when it is combined with Ivermectin.
IxabepiloneThe serum concentration of Ixabepilone can be increased when it is combined with Nelfinavir.
IxazomibThe metabolism of Ixazomib can be decreased when combined with Nelfinavir.
KetamineThe metabolism of Ketamine can be decreased when combined with Nelfinavir.
KetamineThe serum concentration of Nelfinavir can be increased when it is combined with Ketamine.
KetazolamThe serum concentration of Ketazolam can be decreased when it is combined with Nelfinavir.
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Nelfinavir.
KetoconazoleThe serum concentration of Ketoconazole can be decreased when it is combined with Nelfinavir.
KetoconazoleThe serum concentration of Nelfinavir can be increased when it is combined with Ketoconazole.
LacosamideThe serum concentration of Lacosamide can be increased when it is combined with Nelfinavir.
LamivudineThe serum concentration of Lamivudine can be decreased when it is combined with Nelfinavir.
LamotrigineThe serum concentration of Lamotrigine can be decreased when it is combined with Nelfinavir.
LansoprazoleThe serum concentration of the active metabolites of Nelfinavir can be reduced when Nelfinavir is used in combination with Lansoprazole resulting in a loss in efficacy.
LansoprazoleThe serum concentration of Lansoprazole can be decreased when it is combined with Nelfinavir.
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Nelfinavir.
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Nelfinavir.
LedipasvirThe serum concentration of Ledipasvir can be decreased when it is combined with Nelfinavir.
LenalidomideThe serum concentration of Lenalidomide can be decreased when it is combined with Nelfinavir.
LenvatinibNelfinavir may increase the QTc-prolonging activities of Lenvatinib.
LercanidipineThe serum concentration of Lercanidipine can be increased when it is combined with Nelfinavir.
LetrozoleThe metabolism of Letrozole can be decreased when combined with Nelfinavir.
LeuprolideNelfinavir may increase the QTc-prolonging activities of Leuprolide.
LevetiracetamThe serum concentration of Levetiracetam can be decreased when it is combined with Nelfinavir.
LevobupivacaineThe serum concentration of Levobupivacaine can be increased when it is combined with Nelfinavir.
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Nelfinavir.
LevofloxacinNelfinavir may increase the QTc-prolonging activities of Levofloxacin.
LevofloxacinThe serum concentration of Nelfinavir can be increased when it is combined with Levofloxacin.
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Nelfinavir.
LevomilnacipranThe serum concentration of Levomilnacipran can be decreased when it is combined with Nelfinavir.
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Nelfinavir.
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Nelfinavir.
LevothyroxineThe serum concentration of Nelfinavir can be decreased when it is combined with Levothyroxine.
LidocaineThe metabolism of Lidocaine can be decreased when combined with Nelfinavir.
LidocaineThe serum concentration of Nelfinavir can be increased when it is combined with Lidocaine.
LinagliptinThe therapeutic efficacy of Linagliptin can be decreased when used in combination with Nelfinavir.
LiothyronineThe serum concentration of Nelfinavir can be decreased when it is combined with Liothyronine.
LiotrixThe serum concentration of Nelfinavir can be decreased when it is combined with Liotrix.
LiraglutideThe therapeutic efficacy of Liraglutide can be decreased when used in combination with Nelfinavir.
LisinoprilThe serum concentration of Nelfinavir can be increased when it is combined with Lisinopril.
LisurideThe metabolism of Lisuride can be decreased when combined with Nelfinavir.
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Nelfinavir.
LoperamideThe serum concentration of Loperamide can be decreased when it is combined with Nelfinavir.
LoperamideThe serum concentration of Nelfinavir can be increased when it is combined with Loperamide.
LopinavirThe serum concentration of Lopinavir can be decreased when it is combined with Nelfinavir.
LopinavirThe serum concentration of Nelfinavir can be increased when it is combined with Lopinavir.
LoratadineThe metabolism of Loratadine can be decreased when combined with Nelfinavir.
LoratadineThe serum concentration of Nelfinavir can be increased when it is combined with Loratadine.
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Nelfinavir.
LosartanThe serum concentration of Losartan can be decreased when it is combined with Nelfinavir.
LosartanThe serum concentration of Nelfinavir can be increased when it is combined with Losartan.
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Nelfinavir.
LovastatinThe metabolism of Nelfinavir can be decreased when combined with Lovastatin.
LuliconazoleThe serum concentration of Nelfinavir can be increased when it is combined with Luliconazole.
LumacaftorThe serum concentration of Nelfinavir can be decreased when it is combined with Lumacaftor.
LumefantrineThe serum concentration of Lumefantrine can be increased when it is combined with Nelfinavir.
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Nelfinavir.
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Nelfinavir.
MacitentanThe serum concentration of Macitentan can be increased when it is combined with Nelfinavir.
MannitolThe serum concentration of Mannitol can be decreased when it is combined with Nelfinavir.
MaprotilineThe serum concentration of Nelfinavir can be increased when it is combined with Maprotiline.
MaravirocThe serum concentration of Maraviroc can be increased when it is combined with Nelfinavir.
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Nelfinavir.
MebendazoleThe serum concentration of Nelfinavir can be increased when it is combined with Mebendazole.
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be increased when it is combined with Nelfinavir.
MedrysoneThe serum concentration of Medrysone can be increased when it is combined with Nelfinavir.
MefloquineThe metabolism of Mefloquine can be decreased when combined with Nelfinavir.
MefloquineThe serum concentration of Nelfinavir can be increased when it is combined with Mefloquine.
Megestrol acetateThe serum concentration of Nelfinavir can be increased when it is combined with Megestrol acetate.
MelatoninThe metabolism of Melatonin can be decreased when combined with Nelfinavir.
MelengestrolThe serum concentration of Melengestrol can be increased when it is combined with Nelfinavir.
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Nelfinavir.
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Nelfinavir.
MeprobamateThe serum concentration of Nelfinavir can be increased when it is combined with Meprobamate.
MeprobamateThe metabolism of Meprobamate can be decreased when combined with Nelfinavir.
MetforminThe therapeutic efficacy of Metformin can be decreased when used in combination with Nelfinavir.
MethadoneThe serum concentration of Methadone can be decreased when it is combined with Nelfinavir.
MethadoneThe serum concentration of Nelfinavir can be increased when it is combined with Methadone.
MethanthelineThe serum concentration of Nelfinavir can be decreased when it is combined with Methantheline.
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Nelfinavir.
MethotrexateThe serum concentration of Methotrexate can be decreased when it is combined with Nelfinavir.
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Nelfinavir.
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Nelfinavir.
MethsuximideThe metabolism of Methsuximide can be decreased when combined with Nelfinavir.
MethylphenobarbitalThe metabolism of Methylphenobarbital can be decreased when combined with Nelfinavir.
MethylprednisoloneThe serum concentration of Methylprednisolone can be decreased when it is combined with Nelfinavir.
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Nelfinavir.
MetiamideThe serum concentration of Nelfinavir can be decreased when it is combined with Metiamide.
MetoprololThe serum concentration of Metoprolol can be decreased when it is combined with Nelfinavir.
MetoprololThe serum concentration of Nelfinavir can be increased when it is combined with Metoprolol.
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Nelfinavir.
MexiletineThe metabolism of Mexiletine can be decreased when combined with Nelfinavir.
MianserinThe metabolism of Mianserin can be decreased when combined with Nelfinavir.
MibefradilThe metabolism of Mibefradil can be decreased when combined with Nelfinavir.
MibefradilThe serum concentration of Nelfinavir can be increased when it is combined with Mibefradil.
MiconazoleThe metabolism of Miconazole can be decreased when combined with Nelfinavir.
MiconazoleThe serum concentration of Nelfinavir can be increased when it is combined with Miconazole.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Nelfinavir.
MidazolamThe serum concentration of Nelfinavir can be decreased when it is combined with Midazolam.
MifepristoneThe serum concentration of Mifepristone can be increased when it is combined with Nelfinavir.
MifepristoneThe metabolism of Nelfinavir can be decreased when combined with Mifepristone.
MiglitolThe therapeutic efficacy of Miglitol can be decreased when used in combination with Nelfinavir.
MiglustatThe therapeutic efficacy of Miglustat can be decreased when used in combination with Nelfinavir.
MirabegronThe serum concentration of Mirabegron can be decreased when it is combined with Nelfinavir.
MirtazapineThe serum concentration of Mirtazapine can be increased when it is combined with Nelfinavir.
MitiglinideThe therapeutic efficacy of Mitiglinide can be decreased when used in combination with Nelfinavir.
MitomycinThe serum concentration of Nelfinavir can be increased when it is combined with Mitomycin.
MitotaneThe serum concentration of Nelfinavir can be decreased when it is combined with Mitotane.
MitoxantroneThe serum concentration of Mitoxantrone can be decreased when it is combined with Nelfinavir.
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Nelfinavir.
ModafinilThe serum concentration of Nelfinavir can be decreased when it is combined with Modafinil.
ModafinilThe metabolism of Modafinil can be decreased when combined with Nelfinavir.
MometasoneThe serum concentration of Mometasone can be increased when it is combined with Nelfinavir.
MontelukastThe metabolism of Montelukast can be decreased when combined with Nelfinavir.
MorphineThe serum concentration of Morphine can be decreased when it is combined with Nelfinavir.
MorphineThe serum concentration of Nelfinavir can be increased when it is combined with Morphine.
MoxifloxacinNelfinavir may increase the QTc-prolonging activities of Moxifloxacin.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be decreased when it is combined with Nelfinavir.
NadololThe serum concentration of Nadolol can be decreased when it is combined with Nelfinavir.
NafcillinThe serum concentration of Nelfinavir can be decreased when it is combined with Nafcillin.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Nelfinavir.
NaloxoneThe serum concentration of Naloxone can be decreased when it is combined with Nelfinavir.
NaltrexoneThe serum concentration of Nelfinavir can be increased when it is combined with Naltrexone.
NaringeninThe serum concentration of Nelfinavir can be increased when it is combined with Naringenin.
NateglinideThe therapeutic efficacy of Nateglinide can be decreased when used in combination with Nelfinavir.
NefazodoneThe serum concentration of Nefazodone can be increased when it is combined with Nelfinavir.
NefazodoneThe serum concentration of Nelfinavir can be decreased when it is combined with Nefazodone.
NeostigmineThe serum concentration of Nelfinavir can be increased when it is combined with Neostigmine.
NetupitantThe serum concentration of Nelfinavir can be increased when it is combined with Netupitant.
NevirapineThe serum concentration of the active metabolites of Nelfinavir can be reduced when Nelfinavir is used in combination with Nevirapine resulting in a loss in efficacy.
NevirapineThe metabolism of Nevirapine can be decreased when combined with Nelfinavir.
NicardipineThe serum concentration of Nicardipine can be decreased when it is combined with Nelfinavir.
NicardipineThe serum concentration of Nelfinavir can be increased when it is combined with Nicardipine.
NicotineThe metabolism of Nicotine can be decreased when combined with Nelfinavir.
NifedipineThe serum concentration of Nifedipine can be decreased when it is combined with Nelfinavir.
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Nelfinavir.
NilotinibThe metabolism of Nelfinavir can be decreased when combined with Nilotinib.
NilutamideThe metabolism of Nilutamide can be decreased when combined with Nelfinavir.
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Nelfinavir.
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Nelfinavir.
NintedanibThe serum concentration of Nintedanib can be decreased when it is combined with Nelfinavir.
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Nelfinavir.
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Nelfinavir.
NitrazepamThe serum concentration of Nelfinavir can be increased when it is combined with Nitrazepam.
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Nelfinavir.
NitrendipineThe serum concentration of Nelfinavir can be increased when it is combined with Nitrendipine.
NizatidineThe serum concentration of Nelfinavir can be decreased when it is combined with Nizatidine.
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Nelfinavir.
NorethisteroneThe serum concentration of Nelfinavir can be decreased when it is combined with Norethisterone.
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Nelfinavir.
NortriptylineThe serum concentration of Nortriptyline can be increased when it is combined with Nelfinavir.
OfloxacinNelfinavir may increase the QTc-prolonging activities of Ofloxacin.
OlanzapineThe serum concentration of Nelfinavir can be decreased when it is combined with Olanzapine.
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Nelfinavir.
OlaparibThe metabolism of Nelfinavir can be decreased when combined with Olaparib.
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Nelfinavir.
OmbitasvirThe serum concentration of Ombitasvir can be decreased when it is combined with Nelfinavir.
OmeprazoleThe serum concentration of the active metabolites of Nelfinavir can be reduced when Nelfinavir is used in combination with Omeprazole resulting in a loss in efficacy.
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Nelfinavir.
OndansetronNelfinavir may increase the QTc-prolonging activities of Ondansetron.
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Nelfinavir.
OsimertinibThe serum concentration of Nelfinavir can be increased when it is combined with Osimertinib.
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Nelfinavir.
OxazepamThe metabolism of Oxazepam can be decreased when combined with Nelfinavir.
OxiconazoleThe metabolism of Oxiconazole can be decreased when combined with Nelfinavir.
OxybutyninThe serum concentration of Oxybutynin can be increased when it is combined with Nelfinavir.
OxycodoneThe risk or severity of adverse effects can be increased when Nelfinavir is combined with Oxycodone.
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Nelfinavir.
P-NitrophenolThe serum concentration of Nelfinavir can be increased when it is combined with P-Nitrophenol.
PaclitaxelThe serum concentration of Paclitaxel can be decreased when it is combined with Nelfinavir.
PaclitaxelThe serum concentration of Nelfinavir can be increased when it is combined with Paclitaxel.
PalbociclibThe serum concentration of Nelfinavir can be increased when it is combined with Palbociclib.
PaliperidoneNelfinavir may increase the QTc-prolonging activities of Paliperidone.
Palmitic AcidThe serum concentration of Nelfinavir can be increased when it is combined with Palmitic Acid.
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Nelfinavir.
PanobinostatNelfinavir may increase the QTc-prolonging activities of Panobinostat.
PantoprazoleThe serum concentration of the active metabolites of Nelfinavir can be reduced when Nelfinavir is used in combination with Pantoprazole resulting in a loss in efficacy.
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Nelfinavir.
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Nelfinavir.
ParamethasoneThe serum concentration of Paramethasone can be increased when it is combined with Nelfinavir.
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Nelfinavir.
ParicalcitolThe serum concentration of Paricalcitol can be increased when it is combined with Nelfinavir.
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Nelfinavir.
ParoxetineThe serum concentration of Nelfinavir can be increased when it is combined with Paroxetine.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Nelfinavir.
PentamidineNelfinavir may increase the QTc-prolonging activities of Pentamidine.
PentobarbitalThe metabolism of Nelfinavir can be increased when combined with Pentobarbital.
PerampanelThe metabolism of Perampanel can be decreased when combined with Nelfinavir.
PerflutrenNelfinavir may increase the QTc-prolonging activities of Perflutren.
PergolideThe metabolism of Pergolide can be decreased when combined with Nelfinavir.
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Nelfinavir.
PerindoprilThe serum concentration of Nelfinavir can be increased when it is combined with Perindopril.
PermethrinThe metabolism of Permethrin can be decreased when combined with Nelfinavir.
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Nelfinavir.
PethidineThe metabolism of Pethidine can be decreased when combined with Nelfinavir.
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Nelfinavir.
PhenforminThe therapeutic efficacy of Phenformin can be decreased when used in combination with Nelfinavir.
PhenobarbitalThe serum concentration of Phenobarbital can be decreased when it is combined with Nelfinavir.
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Nelfinavir.
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Nelfinavir.
PhenytoinThe serum concentration of Phenytoin can be decreased when it is combined with Nelfinavir.
PhenytoinThe metabolism of Nelfinavir can be increased when combined with Phenytoin.
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Nelfinavir.
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Nelfinavir.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Nelfinavir.
PinacidilThe metabolism of Pinacidil can be decreased when combined with Nelfinavir.
PioglitazoneThe therapeutic efficacy of Pioglitazone can be decreased when used in combination with Nelfinavir.
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Nelfinavir.
PitavastatinThe serum concentration of Pitavastatin can be decreased when it is combined with Nelfinavir.
Platelet Activating FactorThe serum concentration of Nelfinavir can be decreased when it is combined with Platelet Activating Factor.
PodofiloxThe metabolism of Podofilox can be decreased when combined with Nelfinavir.
PomalidomideThe serum concentration of Pomalidomide can be decreased when it is combined with Nelfinavir.
PonatinibThe serum concentration of Ponatinib can be decreased when it is combined with Nelfinavir.
PonatinibThe serum concentration of Nelfinavir can be increased when it is combined with Ponatinib.
PosaconazoleThe metabolism of Posaconazole can be decreased when combined with Nelfinavir.
PosaconazoleThe serum concentration of Nelfinavir can be increased when it is combined with Posaconazole.
PramlintideThe therapeutic efficacy of Pramlintide can be decreased when used in combination with Nelfinavir.
PranlukastThe serum concentration of Pranlukast can be increased when it is combined with Nelfinavir.
PrasugrelThe serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with Nelfinavir resulting in a loss in efficacy.
PravastatinThe serum concentration of Pravastatin can be decreased when it is combined with Nelfinavir.
PravastatinThe serum concentration of Nelfinavir can be increased when it is combined with Pravastatin.
PrazepamThe metabolism of Prazepam can be decreased when combined with Nelfinavir.
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Nelfinavir.
PrazosinThe serum concentration of Prazosin can be decreased when it is combined with Nelfinavir.
PrazosinThe serum concentration of Nelfinavir can be increased when it is combined with Prazosin.
PrednicarbateThe serum concentration of Prednicarbate can be increased when it is combined with Nelfinavir.
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Nelfinavir.
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Nelfinavir.
PregnenoloneThe serum concentration of Pregnenolone can be increased when it is combined with Nelfinavir.
PrimaquineNelfinavir may increase the QTc-prolonging activities of Primaquine.
PrimidoneThe metabolism of Nelfinavir can be increased when combined with Primidone.
ProbenecidThe serum concentration of Nelfinavir can be increased when it is combined with Probenecid.
ProcainamideNelfinavir may increase the QTc-prolonging activities of Procainamide.
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Nelfinavir.
ProgesteroneThe serum concentration of Progesterone can be decreased when it is combined with Nelfinavir.
ProguanilThe metabolism of Proguanil can be decreased when combined with Nelfinavir.
PromazineNelfinavir may increase the QTc-prolonging activities of Promazine.
PromethazineThe serum concentration of Nelfinavir can be increased when it is combined with Promethazine.
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Nelfinavir.
PropofolThe metabolism of Propofol can be decreased when combined with Nelfinavir.
PropranololThe serum concentration of Propranolol can be decreased when it is combined with Nelfinavir.
PropranololThe serum concentration of Nelfinavir can be increased when it is combined with Propranolol.
ProtriptylineThe serum concentration of Protriptyline can be increased when it is combined with Nelfinavir.
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Nelfinavir.
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Nelfinavir.
QuazepamThe metabolism of Quazepam can be decreased when combined with Nelfinavir.
QuercetinThe serum concentration of Nelfinavir can be increased when it is combined with Quercetin.
QuetiapineThe serum concentration of Quetiapine can be decreased when it is combined with Nelfinavir.
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Nelfinavir.
QuinacrineThe serum concentration of Nelfinavir can be increased when it is combined with Quinacrine.
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Nelfinavir.
QuinineThe serum concentration of Quinine can be decreased when it is combined with Nelfinavir.
QuinineThe serum concentration of Nelfinavir can be increased when it is combined with Quinine.
RabeprazoleThe serum concentration of the active metabolites of Nelfinavir can be reduced when Nelfinavir is used in combination with Rabeprazole resulting in a loss in efficacy.
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Nelfinavir.
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Nelfinavir.
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Nelfinavir.
RanitidineThe serum concentration of Nelfinavir can be decreased when it is combined with Ranitidine.
RanolazineThe serum concentration of Nelfinavir can be increased when it is combined with Ranolazine.
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Nelfinavir.
ReboxetineThe serum concentration of Nelfinavir can be increased when it is combined with Reboxetine.
RegorafenibThe serum concentration of Regorafenib can be increased when it is combined with Nelfinavir.
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Nelfinavir.
ReserpineThe serum concentration of Reserpine can be decreased when it is combined with Nelfinavir.
RetapamulinThe serum concentration of Retapamulin can be increased when it is combined with Nelfinavir.
RifabutinThe serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Nelfinavir.
RifabutinThe metabolism of Nelfinavir can be increased when combined with Rifabutin.
RifampicinThe serum concentration of Nelfinavir can be decreased when it is combined with Rifampicin.
RifapentineThe metabolism of Nelfinavir can be increased when combined with Rifapentine.
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Nelfinavir.
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Nelfinavir.
RimexoloneThe serum concentration of Rimexolone can be increased when it is combined with Nelfinavir.
RimonabantThe metabolism of Rimonabant can be decreased when combined with Nelfinavir.
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Nelfinavir.
RisperidoneThe serum concentration of Risperidone can be decreased when it is combined with Nelfinavir.
RitonavirThe serum concentration of Ritonavir can be decreased when it is combined with Nelfinavir.
RivaroxabanThe serum concentration of Rivaroxaban can be decreased when it is combined with Nelfinavir.
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Nelfinavir.
RolapitantThe metabolism of Rolapitant can be decreased when combined with Nelfinavir.
RolapitantThe serum concentration of Nelfinavir can be increased when it is combined with Rolapitant.
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Nelfinavir.
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Nelfinavir.
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Nelfinavir.
RosiglitazoneThe therapeutic efficacy of Rosiglitazone can be decreased when used in combination with Nelfinavir.
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Nelfinavir.
RotigotineThe metabolism of Rotigotine can be decreased when combined with Nelfinavir.
Roxatidine acetateThe serum concentration of Nelfinavir can be decreased when it is combined with Roxatidine acetate.
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Nelfinavir.
RuxolitinibThe serum concentration of Ruxolitinib can be increased when it is combined with Nelfinavir.
Salicylic acidThe serum concentration of Salicylic acid can be decreased when it is combined with Nelfinavir.
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Nelfinavir.
SaquinavirNelfinavir may increase the QTc-prolonging activities of Saquinavir.
SaquinavirThe serum concentration of Nelfinavir can be decreased when it is combined with Saquinavir.
SaxagliptinThe therapeutic efficacy of Saxagliptin can be decreased when used in combination with Nelfinavir.
ScopolamineThe serum concentration of Nelfinavir can be increased when it is combined with Scopolamine.
SelegilineThe serum concentration of Nelfinavir can be increased when it is combined with Selegiline.
SelegilineThe metabolism of Selegiline can be decreased when combined with Nelfinavir.
SelexipagThe serum concentration of Selexipag can be decreased when it is combined with Nelfinavir.
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Nelfinavir.
SertindoleThe metabolism of Sertindole can be decreased when combined with Nelfinavir.
SertralineThe serum concentration of Nelfinavir can be increased when it is combined with Sertraline.
SertralineThe metabolism of Sertraline can be decreased when combined with Nelfinavir.
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Nelfinavir.
SibutramineThe metabolism of Sibutramine can be decreased when combined with Nelfinavir.
SildenafilThe metabolism of Nelfinavir can be decreased when combined with Sildenafil.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Nelfinavir.
SiltuximabThe serum concentration of Nelfinavir can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Nelfinavir can be increased when it is combined with Simeprevir.
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Nelfinavir.
SirolimusThe serum concentration of Sirolimus can be increased when it is combined with Nelfinavir.
SirolimusThe serum concentration of Nelfinavir can be decreased when it is combined with Sirolimus.
SitagliptinThe therapeutic efficacy of Sitagliptin can be decreased when used in combination with Nelfinavir.
SofosbuvirThe serum concentration of Sofosbuvir can be decreased when it is combined with Nelfinavir.
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Nelfinavir.
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Nelfinavir.
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Nelfinavir.
SotalolNelfinavir may increase the QTc-prolonging activities of Sotalol.
SparfloxacinThe serum concentration of Sparfloxacin can be decreased when it is combined with Nelfinavir.
SphingosineThe serum concentration of Sphingosine can be decreased when it is combined with Nelfinavir.
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Nelfinavir.
SpironolactoneThe serum concentration of Nelfinavir can be increased when it is combined with Spironolactone.
St. John's WortThe metabolism of Nelfinavir can be increased when combined with St. John's Wort.
StaurosporineThe serum concentration of Nelfinavir can be increased when it is combined with Staurosporine.
StiripentolThe serum concentration of Nelfinavir can be increased when it is combined with Stiripentol.
StreptozocinThe serum concentration of Nelfinavir can be decreased when it is combined with Streptozocin.
SufentanilThe metabolism of Sufentanil can be decreased when combined with Nelfinavir.
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Nelfinavir.
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Nelfinavir.
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Nelfinavir.
SulfinpyrazoneThe serum concentration of Nelfinavir can be increased when it is combined with Sulfinpyrazone.
SulfisoxazoleNelfinavir may increase the QTc-prolonging activities of Sulfisoxazole.
SulfisoxazoleThe metabolism of Nelfinavir can be decreased when combined with Sulfisoxazole.
SulodexideThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Nelfinavir.
SumatriptanThe serum concentration of Nelfinavir can be increased when it is combined with Sumatriptan.
SunitinibThe metabolism of Sunitinib can be decreased when combined with Nelfinavir.
SunitinibThe serum concentration of Nelfinavir can be increased when it is combined with Sunitinib.
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Nelfinavir.
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Nelfinavir.
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Nelfinavir.
TacrineThe serum concentration of Nelfinavir can be increased when it is combined with Tacrine.
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Nelfinavir.
TacrolimusThe serum concentration of Nelfinavir can be decreased when it is combined with Tacrolimus.
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Nelfinavir.
TAK-390MRThe serum concentration of the active metabolites of Nelfinavir can be reduced when Nelfinavir is used in combination with TAK-390MR resulting in a loss in efficacy.
TamoxifenThe serum concentration of Tamoxifen can be decreased when it is combined with Nelfinavir.
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Nelfinavir.
TapentadolThe metabolism of Tapentadol can be decreased when combined with Nelfinavir.
TasimelteonThe serum concentration of Tasimelteon can be increased when it is combined with Nelfinavir.
TasosartanThe metabolism of Tasosartan can be decreased when combined with Nelfinavir.
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Nelfinavir.
Taurocholic AcidThe serum concentration of Taurocholic Acid can be decreased when it is combined with Nelfinavir.
Taurocholic AcidThe serum concentration of Nelfinavir can be increased when it is combined with Taurocholic Acid.
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Nelfinavir.
TelaprevirThe metabolism of Nelfinavir can be decreased when combined with Telaprevir.
TelaprevirThe serum concentration of Telaprevir can be decreased when it is combined with Nelfinavir.
TelavancinNelfinavir may increase the QTc-prolonging activities of Telavancin.
TelithromycinNelfinavir may increase the QTc-prolonging activities of Telithromycin.
TelithromycinThe metabolism of Nelfinavir can be decreased when combined with Telithromycin.
TelmisartanThe serum concentration of Nelfinavir can be increased when it is combined with Telmisartan.
TemazepamThe metabolism of Temazepam can be decreased when combined with Nelfinavir.
TemsirolimusThe serum concentration of Temsirolimus can be decreased when it is combined with Nelfinavir.
TemsirolimusThe serum concentration of Nelfinavir can be increased when it is combined with Temsirolimus.
TeniposideThe metabolism of Teniposide can be decreased when combined with Nelfinavir.
TerazosinThe serum concentration of Nelfinavir can be increased when it is combined with Terazosin.
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Nelfinavir.
TerfenadineThe serum concentration of Terfenadine can be increased when it is combined with Nelfinavir.
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Nelfinavir.
TesmilifeneThe serum concentration of Nelfinavir can be decreased when it is combined with Tesmilifene.
TestosteroneThe serum concentration of Nelfinavir can be increased when it is combined with Testosterone.
TestosteroneThe metabolism of Testosterone can be decreased when combined with Nelfinavir.
TetrabenazineNelfinavir may increase the QTc-prolonging activities of Tetrabenazine.
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Nelfinavir.
ThalidomideThe metabolism of Thalidomide can be decreased when combined with Nelfinavir.
TheophyllineThe serum concentration of Theophylline can be decreased when it is combined with Nelfinavir.
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Nelfinavir.
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Nelfinavir.
TiagabineThe metabolism of Tiagabine can be decreased when combined with Nelfinavir.
TianeptineThe serum concentration of Tianeptine can be increased when it is combined with Nelfinavir.
TicagrelorThe serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Nelfinavir resulting in a loss in efficacy.
TicagrelorThe serum concentration of Nelfinavir can be increased when it is combined with Ticagrelor.
TiclopidineThe metabolism of Nelfinavir can be decreased when combined with Ticlopidine.
TimololThe serum concentration of Timolol can be decreased when it is combined with Nelfinavir.
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Nelfinavir.
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Nelfinavir.
TipranavirThe serum concentration of Nelfinavir can be decreased when it is combined with Tipranavir.
TipranavirThe metabolism of Tipranavir can be decreased when combined with Nelfinavir.
TixocortolThe serum concentration of Tixocortol can be increased when it is combined with Nelfinavir.
TocilizumabThe serum concentration of Nelfinavir can be decreased when it is combined with Tocilizumab.
TofacitinibThe metabolism of Tofacitinib can be decreased when combined with Nelfinavir.
TolazamideThe therapeutic efficacy of Tolazamide can be decreased when used in combination with Nelfinavir.
TolbutamideThe therapeutic efficacy of Tolbutamide can be decreased when used in combination with Nelfinavir.
TolterodineThe metabolism of Tolterodine can be decreased when combined with Nelfinavir.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Nelfinavir.
TopiramateThe metabolism of Nelfinavir can be decreased when combined with Topiramate.
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Nelfinavir.
ToremifeneThe risk or severity of adverse effects can be increased when Nelfinavir is combined with Toremifene.
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Nelfinavir.
TramadolThe serum concentration of Tramadol can be increased when it is combined with Nelfinavir.
TranylcypromineThe metabolism of Nelfinavir can be decreased when combined with Tranylcypromine.
Trastuzumab emtansineThe serum concentration of the active metabolites of Trastuzumab emtansine can be increased when Trastuzumab emtansine is used in combination with Nelfinavir.
TrazodoneThe serum concentration of Trazodone can be increased when it is combined with Nelfinavir.
TrazodoneThe serum concentration of Nelfinavir can be decreased when it is combined with Trazodone.
TretinoinThe metabolism of Tretinoin can be decreased when combined with Nelfinavir.
TriamcinoloneThe serum concentration of Triamcinolone can be increased when it is combined with Nelfinavir.
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Nelfinavir.
TrifluoperazineThe serum concentration of Nelfinavir can be increased when it is combined with Trifluoperazine.
TriflupromazineThe serum concentration of Nelfinavir can be increased when it is combined with Triflupromazine.
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Nelfinavir.
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Nelfinavir.
TrimethoprimThe serum concentration of Nelfinavir can be decreased when it is combined with Trimethoprim.
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Nelfinavir.
TroglitazoneThe therapeutic efficacy of Troglitazone can be decreased when used in combination with Nelfinavir.
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Nelfinavir.
TroleandomycinThe serum concentration of Nelfinavir can be increased when it is combined with Troleandomycin.
UdenafilThe metabolism of Udenafil can be decreased when combined with Nelfinavir.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Nelfinavir.
UmeclidiniumThe serum concentration of Umeclidinium can be decreased when it is combined with Nelfinavir.
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Nelfinavir.
Valproic AcidThe metabolism of Valproic Acid can be decreased when combined with Nelfinavir.
VandetanibThe metabolism of Vandetanib can be decreased when combined with Nelfinavir.
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Nelfinavir.
VardenafilThe serum concentration of Vardenafil can be increased when it is combined with Nelfinavir.
VecuroniumThe serum concentration of Vecuronium can be decreased when it is combined with Nelfinavir.
VemurafenibThe serum concentration of Vemurafenib can be increased when it is combined with Nelfinavir.
VenlafaxineThe metabolism of Nelfinavir can be decreased when combined with Venlafaxine.
VenlafaxineThe serum concentration of Venlafaxine can be decreased when it is combined with Nelfinavir.
VerapamilThe metabolism of Nelfinavir can be decreased when combined with Verapamil.
VerapamilThe serum concentration of Verapamil can be decreased when it is combined with Nelfinavir.
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Nelfinavir.
VilanterolThe metabolism of Vilanterol can be decreased when combined with Nelfinavir.
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Nelfinavir.
VildagliptinThe therapeutic efficacy of Vildagliptin can be decreased when used in combination with Nelfinavir.
VinblastineThe serum concentration of Vinblastine can be decreased when it is combined with Nelfinavir.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Nelfinavir.
VincristineThe serum concentration of Nelfinavir can be decreased when it is combined with Vincristine.
VindesineThe serum concentration of Vindesine can be increased when it is combined with Nelfinavir.
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Nelfinavir.
VinorelbineThe serum concentration of Nelfinavir can be increased when it is combined with Vinorelbine.
VismodegibThe serum concentration of Vismodegib can be decreased when it is combined with Nelfinavir.
VogliboseThe therapeutic efficacy of Voglibose can be decreased when used in combination with Nelfinavir.
VorapaxarThe serum concentration of Vorapaxar can be increased when it is combined with Nelfinavir.
VoriconazoleThe serum concentration of Nelfinavir can be increased when it is combined with Voriconazole.
VoriconazoleThe metabolism of Voriconazole can be decreased when combined with Nelfinavir.
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Nelfinavir.
WarfarinThe serum concentration of Warfarin can be decreased when it is combined with Nelfinavir.
YohimbineThe metabolism of Yohimbine can be decreased when combined with Nelfinavir.
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Nelfinavir.
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Nelfinavir.
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Nelfinavir.
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Nelfinavir.
ZileutonThe metabolism of Zileuton can be decreased when combined with Nelfinavir.
ZimelidineThe serum concentration of Nelfinavir can be increased when it is combined with Zimelidine.
ZiprasidoneThe metabolism of Nelfinavir can be decreased when combined with Ziprasidone.
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Nelfinavir.
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Nelfinavir.
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Nelfinavir.
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Nelfinavir.
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Nelfinavir.
Food Interactions
  • Food significantly increases absorption (2 to 3 times).
  • Take with food.

Targets

Kind
Protein
Organism
Human immunodeficiency virus
Pharmacological action
yes
Actions
inhibitor
General Function:
Aspartic-type endopeptidase activity
Specific Function:
Not Available
Gene Name:
HIV-1 protease
Uniprot ID:
O90777
Molecular Weight:
10724.61 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Garriga C, Perez-Elias MJ, Delgado R, Ruiz L, Najera R, Pumarola T, Alonso-Socas Mdel M, Garcia-Bujalance S, Menendez-Arias L: Mutational patterns and correlated amino acid substitutions in the HIV-1 protease after virological failure to nelfinavir- and lopinavir/ritonavir-based treatments. J Med Virol. 2007 Nov;79(11):1617-28. [PubMed:17854027 ]
  4. Wittayanarakul K, Hannongbua S, Feig M: Accurate prediction of protonation state as a prerequisite for reliable MM-PB(GB)SA binding free energy calculations of HIV-1 protease inhibitors. J Comput Chem. 2008 Apr 15;29(5):673-85. [PubMed:17849388 ]
  5. Dandache S, Sevigny G, Yelle J, Stranix BR, Parkin N, Schapiro JM, Wainberg MA, Wu JJ: In vitro antiviral activity and cross-resistance profile of PL-100, a novel protease inhibitor of human immunodeficiency virus type 1. Antimicrob Agents Chemother. 2007 Nov;51(11):4036-43. Epub 2007 Jul 16. [PubMed:17638694 ]
  6. Perez MA, Fernandes PA, Ramos MJ: Drug design: new inhibitors for HIV-1 protease based on Nelfinavir as lead. J Mol Graph Model. 2007 Oct;26(3):634-42. Epub 2007 Mar 24. [PubMed:17459746 ]
  7. Velazquez-Campoy A, Kiso Y, Freire E: The binding energetics of first- and second-generation HIV-1 protease inhibitors: implications for drug design. Arch Biochem Biophys. 2001 Jun 15;390(2):169-75. [PubMed:11396919 ]
  8. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
References
  1. Hesse LM, von Moltke LL, Shader RI, Greenblatt DJ: Ritonavir, efavirenz, and nelfinavir inhibit CYP2B6 activity in vitro: potential drug interactions with bupropion. Drug Metab Dispos. 2001 Feb;29(2):100-2. [PubMed:11159797 ]
  2. Tanabe M, Hashimoto M, Ono H: Imidazoline I(1) receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson's disease. Eur J Pharmacol. 2008 Jul 28;589(1-3):102-5. doi: 10.1016/j.ejphar.2008.06.013. Epub 2008 Jun 7. [PubMed:18602099 ]
  3. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitorinducer
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Perloff MD, von Moltke LL, Fahey JM, Daily JP, Greenblatt DJ: Induction of P-glycoprotein expression by HIV protease inhibitors in cell culture. AIDS. 2000 Jun 16;14(9):1287-9. [PubMed:10894301 ]
  2. Choo EF, Leake B, Wandel C, Imamura H, Wood AJ, Wilkinson GR, Kim RB: Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes. Drug Metab Dispos. 2000 Jun;28(6):655-60. [PubMed:10820137 ]
  3. Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. [PubMed:12699389 ]
  4. Kim RB, Fromm MF, Wandel C, Leake B, Wood AJ, Roden DM, Wilkinson GR: The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors. J Clin Invest. 1998 Jan 15;101(2):289-94. [PubMed:9435299 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Secondary active organic cation transmembrane transporter activity
Specific Function:
Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine...
Gene Name:
SLC22A1
Uniprot ID:
O15245
Molecular Weight:
61153.345 Da
References
  1. Zhang L, Gorset W, Washington CB, Blaschke TF, Kroetz DL, Giacomini KM: Interactions of HIV protease inhibitors with a human organic cation transporter in a mammalian expression system. Drug Metab Dispos. 2000 Mar;28(3):329-34. [PubMed:10681378 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.
Gene Name:
SLCO1A2
Uniprot ID:
P46721
Molecular Weight:
74144.105 Da
References
  1. Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB: OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos. 1999 Aug;27(8):866-71. [PubMed:10421612 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from t...
Gene Name:
ABCG2
Uniprot ID:
Q9UNQ0
Molecular Weight:
72313.47 Da
References
  1. Gupta A, Zhang Y, Unadkat JD, Mao Q: HIV protease inhibitors are inhibitors but not substrates of the human breast cancer resistance protein (BCRP/ABCG2). J Pharmacol Exp Ther. 2004 Jul;310(1):334-41. Epub 2004 Mar 8. [PubMed:15007102 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.
Gene Name:
SLCO1B1
Uniprot ID:
Q9Y6L6
Molecular Weight:
76447.99 Da
References
  1. Tirona RG, Leake BF, Wolkoff AW, Kim RB: Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation. J Pharmacol Exp Ther. 2003 Jan;304(1):223-8. [PubMed:12490595 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23