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Identification
NameIndinavir
Accession NumberDB00224  (APRD00069)
TypeSmall Molecule
GroupsApproved
DescriptionA potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem]
Structure
Thumb
Synonyms
(1(1S,2R),5(S))-2,3,5-Trideoxy-N-(2,3-dihydro-2-hydroxy-1H-inden-1-yl)-5-(2-(((1,1-dimethylethyl)amino)carbonyl)-4-(3-pyridinylmethyl)-1-piperazinyl)-2-(phenylmethyl)-D-erythro-pentonamide
Indinavir anhydrous
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Crixivancapsule200 mgoralMerck Canada Inc1996-09-262014-09-19Canada
Crixivancapsule200 mg/1oralMerck Sharp & Dohme Corp.1996-03-13Not applicableUs
CrixivanCapsule, hard200 mgOral useMerck Sharp & Dohme Ltd1996-10-04Not applicableEu
Crixivancapsule400 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Crixivancapsule300 mgoralMerck Canada IncNot applicableNot applicableCanada
Crixivancapsule400 mg/1oralMerck Sharp & Dohme Corp.1996-03-13Not applicableUs
CrixivanCapsule, hard400 mgOral useMerck Sharp & Dohme Ltd1996-10-04Not applicableEu
Crixivancapsule400 mg/1oralAvera Mc Kennan Hospital2015-03-01Not applicableUs
CrixivanCapsule, hard200 mgOral useMerck Sharp & Dohme Ltd1996-10-04Not applicableEu
Crixivancapsule400 mg/1oralSTAT Rx USA LLC1996-03-13Not applicableUs
CrixivanCapsule, hard400 mgOral useMerck Sharp & Dohme Ltd1996-10-04Not applicableEu
Crixivancapsule400 mgoralMerck Canada Inc1996-09-30Not applicableCanada
CrixivanCapsule, hard200 mgOral useMerck Sharp & Dohme Ltd1996-10-04Not applicableEu
Crixivancapsule400 mg/1oralRebel Distributors Corp1996-03-13Not applicableUs
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Indinavir monohydrate
180683-37-8
Thumb
  • InChI Key: XTYSXGHMTNTKFH-BDEHJDMKSA-N
  • Monoisotopic Mass: 631.373369698
  • Average Mass: 631.818
DBSALT001802
Indinavir sulfate
157810-81-6
Thumb
  • InChI Key: NUBQKPWHXMGDLP-BDEHJDMKSA-N
  • Monoisotopic Mass: 711.330184259
  • Average Mass: 711.868
DBSALT000338
Categories
UNII9MG78X43ZT
CAS number150378-17-9
WeightAverage: 613.7895
Monoisotopic: 613.362805017
Chemical FormulaC36H47N5O4
InChI KeyCBVCZFGXHXORBI-PXQQMZJSSA-N
InChI
InChI=1S/C36H47N5O4/c1-36(2,3)39-35(45)31-24-40(22-26-12-9-15-37-21-26)16-17-41(31)23-29(42)19-28(18-25-10-5-4-6-11-25)34(44)38-33-30-14-8-7-13-27(30)20-32(33)43/h4-15,21,28-29,31-33,42-43H,16-20,22-24H2,1-3H3,(H,38,44)(H,39,45)/t28-,29+,31+,32-,33+/m1/s1
IUPAC Name
(2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]carbamoyl}butyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide
SMILES
CC(C)(C)NC(=O)[C@@H]1CN(CC2=CN=CC=C2)CCN1C[C@@H](O)C[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]1[[email protected]](O)CC2=CC=CC=C12
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as alpha amino acid amides. These are amide derivatives of alpha amino acids.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentAlpha amino acid amides
Alternative Parents
Substituents
  • Alpha-amino acid amide
  • Phenylpropylamine
  • Piperazine-2-carboxamide
  • Indane
  • Aralkylamine
  • N-alkylpiperazine
  • Fatty acyl
  • Benzenoid
  • Pyridine
  • Piperazine
  • N-acyl-amine
  • Fatty amide
  • 1,4-diazinane
  • Monocyclic benzene moiety
  • Heteroaromatic compound
  • Tertiary aliphatic amine
  • Tertiary amine
  • Secondary carboxylic acid amide
  • Secondary alcohol
  • Carboxamide group
  • 1,2-aminoalcohol
  • Azacycle
  • Organoheterocyclic compound
  • Carboxylic acid amide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Alcohol
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationIndinavir is an antiretroviral drug for the treatment of HIV infection.
PharmacodynamicsIndinavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease. HIV-1 protease is an enzyme required for the proteolytic cleavage of the viral polyprotein precursors into the individual functional proteins found in infectious HIV-1. Indinavir binds to the protease active site and inhibits the activity of the enzyme. This inhibition prevents cleavage of the viral polyproteins resulting in the formation of immature non-infectious viral particles. Protease inhibitors are almost always used in combination with at least two other anti-HIV drugs.
Mechanism of actionIndinavir inhibits the HIV viral protease enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles.
Related Articles
AbsorptionRapidly absorbed
Volume of distributionNot Available
Protein binding60%
Metabolism

Hepatic. Seven metabolites have been identified, one glucuronide conjugate and six oxidative metabolites. In vitro studies indicate that cytochrome P-450 3A4 (CYP3A4) is the major enzyme responsible for formation of the oxidative metabolites.

SubstrateEnzymesProduct
Indinavir
Metabolite M6Details
Route of eliminationLess than 20% of indinavir is excreted unchanged in the urine.
Half life1.8 (± 0.4) hours
ClearanceNot Available
ToxicitySymptoms of overdose include myocardial infarction and angina pectoris.
Affected organisms
  • Human Immunodeficiency Virus
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.821
Blood Brain Barrier-0.9923
Caco-2 permeable-0.8183
P-glycoprotein substrateSubstrate0.8899
P-glycoprotein inhibitor IInhibitor0.7987
P-glycoprotein inhibitor IINon-inhibitor0.5819
Renal organic cation transporterNon-inhibitor0.8501
CYP450 2C9 substrateNon-substrate0.7816
CYP450 2D6 substrateSubstrate0.8918
CYP450 3A4 substrateSubstrate0.7831
CYP450 1A2 substrateNon-inhibitor0.9057
CYP450 2C9 inhibitorNon-inhibitor0.6278
CYP450 2D6 inhibitorNon-inhibitor0.7476
CYP450 2C19 inhibitorNon-inhibitor0.6264
CYP450 3A4 inhibitorInhibitor0.6525
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7808
Ames testNon AMES toxic0.8629
CarcinogenicityNon-carcinogens0.887
BiodegradationNot ready biodegradable0.9951
Rat acute toxicity2.1844 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9557
hERG inhibition (predictor II)Inhibitor0.7265
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Merck sharp and dohme corp
Packagers
Dosage forms
FormRouteStrength
Capsuleoral200 mg/1
Capsuleoral200 mg
Capsuleoral300 mg
Capsuleoral400 mg
Capsuleoral400 mg/1
Capsule, hardOral use200 mg
Capsule, hardOral use400 mg
Prices
Unit descriptionCostUnit
Crixivan 360 200 mg capsule Bottle570.02USD bottle
Crixivan 400 mg capsule2.86USD each
Crixivan 333 mg capsule2.54USD each
Crixivan 200 mg capsule1.52USD each
Crixivan 100 mg capsule0.76USD each
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2081970 No1997-07-082012-11-02Canada
US5413999 No1995-05-092012-05-09Us
US6645961 No1998-03-042018-03-04Us
US6689761 No2001-02-102021-02-10Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point167.5-168 °CNot Available
water solubility0.015 mg/mlNot Available
logP2.9Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0482 mg/mLALOGPS
logP3.26ALOGPS
logP2.81ChemAxon
logS-4.1ALOGPS
pKa (Strongest Acidic)13.19ChemAxon
pKa (Strongest Basic)7.37ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area118.03 Å2ChemAxon
Rotatable Bond Count12ChemAxon
Refractivity175.89 m3·mol-1ChemAxon
Polarizability68.63 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

DrugSyn.org

US5413999
General ReferencesNot Available
External Links
ATC CodesJ05AE02
AHFS Codes
  • 08:18.08.08
PDB Entries
FDA labelDownload (671 KB)
MSDSDownload (57 KB)
Interactions
Drug Interactions
Drug
4-AndrostenedioneThe serum concentration of 4-Androstenedione can be increased when it is combined with Indinavir.
4-MethoxyamphetamineThe metabolism of 4-Methoxyamphetamine can be decreased when combined with Indinavir.
AbacavirThe serum concentration of Abacavir can be decreased when it is combined with Indinavir.
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Indinavir.
AcarboseThe therapeutic efficacy of Acarbose can be decreased when used in combination with Indinavir.
AcebutololThe serum concentration of Acebutolol can be decreased when it is combined with Indinavir.
AceclofenacThe metabolism of Aceclofenac can be decreased when combined with Indinavir.
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Indinavir.
AcetaminophenThe serum concentration of Acetaminophen can be decreased when it is combined with Indinavir.
AcetaminophenThe serum concentration of Indinavir can be increased when it is combined with Acetaminophen.
AcetohexamideThe therapeutic efficacy of Acetohexamide can be decreased when used in combination with Indinavir.
AcetylcholineThe metabolism of Acetylcholine can be decreased when combined with Indinavir.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be decreased when it is combined with Indinavir.
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Indinavir.
AfatinibThe serum concentration of Afatinib can be decreased when it is combined with Indinavir.
AfatinibThe serum concentration of Indinavir can be increased when it is combined with Afatinib.
AicarThe therapeutic efficacy of Aicar can be decreased when used in combination with Indinavir.
AjmalineThe metabolism of Ajmaline can be decreased when combined with Indinavir.
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Indinavir.
AlbendazoleThe serum concentration of Indinavir can be increased when it is combined with Albendazole.
AlclometasoneThe serum concentration of Alclometasone can be increased when it is combined with Indinavir.
AldosteroneThe serum concentration of Aldosterone can be decreased when it is combined with Indinavir.
AlectinibThe serum concentration of Indinavir can be increased when it is combined with Alectinib.
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Indinavir.
AlfentanilThe serum concentration of Indinavir can be increased when it is combined with Alfentanil.
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Indinavir.
AliskirenThe metabolism of Aliskiren can be decreased when combined with Indinavir.
AlitretinoinThe serum concentration of Alitretinoin can be decreased when it is combined with Indinavir.
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Indinavir.
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Indinavir.
AlogliptinThe therapeutic efficacy of Alogliptin can be decreased when used in combination with Indinavir.
AlosetronThe serum concentration of Alosetron can be increased when it is combined with Indinavir.
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Indinavir.
AlprenololThe metabolism of Alprenolol can be decreased when combined with Indinavir.
AmantadineThe serum concentration of Indinavir can be increased when it is combined with Amantadine.
AmbrisentanThe serum concentration of Ambrisentan can be decreased when it is combined with Indinavir.
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Indinavir.
AmcinonideThe serum concentration of Amcinonide can be increased when it is combined with Indinavir.
AmineptineThe serum concentration of Amineptine can be increased when it is combined with Indinavir.
Aminohippuric acidThe serum concentration of Indinavir can be increased when it is combined with Aminohippuric acid.
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Indinavir.
AminophyllineThe serum concentration of Aminophylline can be decreased when it is combined with Indinavir.
AmiodaroneThe serum concentration of Amiodarone can be increased when it is combined with Indinavir.
AmiodaroneThe serum concentration of Indinavir can be decreased when it is combined with Amiodarone.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Indinavir.
AmlodipineThe metabolism of Amlodipine can be decreased when combined with Indinavir.
AmlodipineThe serum concentration of Indinavir can be increased when it is combined with Amlodipine.
AmoxapineThe metabolism of Amoxapine can be decreased when combined with Indinavir.
AmoxicillinThe metabolism of Amoxicillin can be decreased when combined with Indinavir.
AmphetamineThe metabolism of Amphetamine can be decreased when combined with Indinavir.
AmprenavirThe serum concentration of Indinavir can be decreased when it is combined with Amprenavir.
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Indinavir.
AmsacrineThe serum concentration of Indinavir can be increased when it is combined with Amsacrine.
AmsacrineThe metabolism of Amsacrine can be decreased when combined with Indinavir.
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Indinavir.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Indinavir.
ApremilastThe metabolism of Apremilast can be decreased when combined with Indinavir.
AprepitantThe serum concentration of Indinavir can be increased when it is combined with Aprepitant.
AprepitantThe metabolism of Aprepitant can be decreased when combined with Indinavir.
AprindineThe metabolism of Aprindine can be decreased when combined with Indinavir.
Arachidonic AcidThe metabolism of Arachidonic Acid can be decreased when combined with Indinavir.
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Indinavir.
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Indinavir.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Indinavir.
Arsenic trioxideThe serum concentration of Arsenic trioxide can be decreased when it is combined with Indinavir.
ArtemetherThe metabolism of Artemether can be decreased when combined with Indinavir.
AsenapineThe serum concentration of Indinavir can be decreased when it is combined with Asenapine.
AsenapineThe metabolism of Asenapine can be decreased when combined with Indinavir.
AstemizoleThe serum concentration of Astemizole can be increased when it is combined with Indinavir.
AtazanavirThe risk or severity of adverse effects can be increased when Atazanavir is combined with Indinavir.
AtazanavirThe serum concentration of Atazanavir can be decreased when it is combined with Indinavir.
AtenololThe serum concentration of Atenolol can be decreased when it is combined with Indinavir.
AtenololThe serum concentration of Indinavir can be increased when it is combined with Atenolol.
AtomoxetineThe metabolism of Indinavir can be decreased when combined with Atomoxetine.
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Indinavir.
AtovaquoneThe serum concentration of Indinavir can be decreased when it is combined with Atovaquone.
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Indinavir.
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Indinavir.
AzelastineThe serum concentration of Indinavir can be increased when it is combined with Azelastine.
AzelastineThe metabolism of Azelastine can be decreased when combined with Indinavir.
AzithromycinThe metabolism of Azithromycin can be decreased when combined with Indinavir.
AzithromycinThe serum concentration of Indinavir can be increased when it is combined with Azithromycin.
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Indinavir.
BarnidipineThe serum concentration of Barnidipine can be increased when it is combined with Indinavir.
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be increased when it is combined with Indinavir.
BedaquilineThe serum concentration of Bedaquiline can be increased when it is combined with Indinavir.
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Indinavir.
BenzocaineThe serum concentration of Indinavir can be increased when it is combined with Benzocaine.
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Indinavir.
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Indinavir.
BepridilThe serum concentration of Indinavir can be increased when it is combined with Bepridil.
BepridilThe metabolism of Bepridil can be decreased when combined with Indinavir.
BetamethasoneThe serum concentration of Betamethasone can be decreased when it is combined with Indinavir.
BetaxololThe metabolism of Betaxolol can be decreased when combined with Indinavir.
BexaroteneThe serum concentration of Indinavir can be decreased when it is combined with Bexarotene.
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Indinavir.
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Indinavir.
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Indinavir.
BiperidenThe serum concentration of Indinavir can be increased when it is combined with Biperiden.
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Indinavir.
BoceprevirThe serum concentration of Indinavir can be decreased when it is combined with Boceprevir.
BortezomibThe serum concentration of Bortezomib can be increased when it is combined with Indinavir.
BortezomibThe metabolism of Indinavir can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Indinavir can be decreased when it is combined with Bosentan.
BosentanThe serum concentration of Bosentan can be increased when it is combined with Indinavir.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Indinavir.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Indinavir.
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Indinavir.
BrinzolamideThe serum concentration of Brinzolamide can be increased when it is combined with Indinavir.
BromazepamThe metabolism of Bromazepam can be decreased when combined with Indinavir.
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Indinavir.
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Indinavir.
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Indinavir.
BuforminThe therapeutic efficacy of Buformin can be decreased when used in combination with Indinavir.
BufuralolThe metabolism of Bufuralol can be decreased when combined with Indinavir.
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Indinavir.
BuprenorphineThe serum concentration of Indinavir can be increased when it is combined with Buprenorphine.
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Indinavir.
BupropionThe metabolism of Bupropion can be decreased when combined with Indinavir.
BuspironeThe serum concentration of Indinavir can be increased when it is combined with Buspirone.
BuspironeThe metabolism of Buspirone can be decreased when combined with Indinavir.
BusulfanThe metabolism of Busulfan can be decreased when combined with Indinavir.
CabazitaxelThe serum concentration of Cabazitaxel can be decreased when it is combined with Indinavir.
CabazitaxelThe serum concentration of Indinavir can be increased when it is combined with Cabazitaxel.
CabergolineThe serum concentration of Cabergoline can be increased when it is combined with Indinavir.
CabozantinibThe serum concentration of Cabozantinib can be increased when it is combined with Indinavir.
CaffeineThe serum concentration of Caffeine can be decreased when it is combined with Indinavir.
CaffeineThe serum concentration of Indinavir can be increased when it is combined with Caffeine.
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Indinavir.
CamptothecinThe serum concentration of Camptothecin can be decreased when it is combined with Indinavir.
CanagliflozinThe therapeutic efficacy of Canagliflozin can be decreased when used in combination with Indinavir.
CanagliflozinThe serum concentration of Indinavir can be increased when it is combined with Canagliflozin.
CandesartanThe serum concentration of Indinavir can be increased when it is combined with Candesartan.
CandesartanThe metabolism of Candesartan can be decreased when combined with Indinavir.
CaptoprilThe serum concentration of Indinavir can be increased when it is combined with Captopril.
CaptoprilThe metabolism of Captopril can be decreased when combined with Indinavir.
CarbamazepineThe serum concentration of Carbamazepine can be decreased when it is combined with Indinavir.
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Indinavir.
CarfilzomibThe serum concentration of Carfilzomib can be decreased when it is combined with Indinavir.
CariprazineThe metabolism of Cariprazine can be decreased when combined with Indinavir.
CarisoprodolThe metabolism of Carisoprodol can be decreased when combined with Indinavir.
CarteololThe metabolism of Carteolol can be decreased when combined with Indinavir.
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Indinavir.
CaspofunginThe serum concentration of Indinavir can be increased when it is combined with Caspofungin.
CastanospermineThe therapeutic efficacy of Castanospermine can be decreased when used in combination with Indinavir.
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Indinavir.
CeliprololThe metabolism of Celiprolol can be decreased when combined with Indinavir.
CephalexinThe metabolism of Cephalexin can be decreased when combined with Indinavir.
CeritinibThe serum concentration of Indinavir can be increased when it is combined with Ceritinib.
CerivastatinThe serum concentration of Cerivastatin can be decreased when it is combined with Indinavir.
CevimelineThe metabolism of Cevimeline can be decreased when combined with Indinavir.
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Indinavir.
ChloramphenicolThe metabolism of Chloramphenicol can be decreased when combined with Indinavir.
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Indinavir.
ChloroquineThe serum concentration of Indinavir can be increased when it is combined with Chloroquine.
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Indinavir.
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Indinavir.
ChlorpromazineThe serum concentration of Chlorpromazine can be decreased when it is combined with Indinavir.
ChlorpromazineThe serum concentration of Indinavir can be increased when it is combined with Chlorpromazine.
ChlorpropamideThe therapeutic efficacy of Chlorpropamide can be decreased when used in combination with Indinavir.
ChlorpropamideThe serum concentration of Indinavir can be increased when it is combined with Chlorpropamide.
ChlorprothixeneThe serum concentration of Indinavir can be increased when it is combined with Chlorprothixene.
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Indinavir.
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Indinavir.
CholesterolThe serum concentration of Indinavir can be increased when it is combined with Cholesterol.
Cholic AcidThe serum concentration of Indinavir can be decreased when it is combined with Cholic Acid.
CiclesonideThe serum concentration of Ciclesonide can be increased when it is combined with Indinavir.
CiglitazoneThe therapeutic efficacy of Ciglitazone can be decreased when used in combination with Indinavir.
CilazaprilThe serum concentration of Indinavir can be increased when it is combined with Cilazapril.
CilostazolThe metabolism of Cilostazol can be decreased when combined with Indinavir.
CimetidineThe serum concentration of Indinavir can be decreased when it is combined with Cimetidine.
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Indinavir.
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Indinavir.
CiprofloxacinThe serum concentration of Ciprofloxacin can be decreased when it is combined with Indinavir.
CiprofloxacinThe serum concentration of Indinavir can be increased when it is combined with Ciprofloxacin.
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Indinavir.
CisplatinThe serum concentration of Cisplatin can be decreased when it is combined with Indinavir.
CitalopramThe serum concentration of Citalopram can be decreased when it is combined with Indinavir.
CitalopramThe serum concentration of Indinavir can be increased when it is combined with Citalopram.
ClarithromycinThe serum concentration of Clarithromycin can be decreased when it is combined with Indinavir.
ClarithromycinThe serum concentration of Indinavir can be increased when it is combined with Clarithromycin.
ClemastineThe metabolism of Indinavir can be decreased when combined with Clemastine.
ClevidipineThe metabolism of Clevidipine can be decreased when combined with Indinavir.
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Indinavir.
ClobazamThe serum concentration of Clobazam can be decreased when it is combined with Indinavir.
Clobetasol propionateThe serum concentration of Clobetasol propionate can be increased when it is combined with Indinavir.
ClocortoloneThe serum concentration of Clocortolone can be increased when it is combined with Indinavir.
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Indinavir.
ClofazimineThe serum concentration of Indinavir can be increased when it is combined with Clofazimine.
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Indinavir.
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Indinavir.
ClomifeneThe serum concentration of Clomifene can be decreased when it is combined with Indinavir.
ClomipramineThe serum concentration of Clomipramine can be increased when it is combined with Indinavir.
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Indinavir.
ClonidineThe serum concentration of Clonidine can be decreased when it is combined with Indinavir.
ClopidogrelThe serum concentration of Clopidogrel can be decreased when it is combined with Indinavir.
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Indinavir.
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Indinavir.
ClotrimazoleThe metabolism of Indinavir can be decreased when combined with Clotrimazole.
ClozapineThe serum concentration of Clozapine can be decreased when it is combined with Indinavir.
CobicistatThe serum concentration of Indinavir can be increased when it is combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Indinavir.
CocaineThe metabolism of Cocaine can be decreased when combined with Indinavir.
CodeineThe therapeutic efficacy of Codeine can be decreased when used in combination with Indinavir.
ColchicineThe serum concentration of Colchicine can be decreased when it is combined with Indinavir.
ColchicineThe serum concentration of Indinavir can be increased when it is combined with Colchicine.
ColforsinThe serum concentration of Indinavir can be increased when it is combined with Colforsin.
ConivaptanThe serum concentration of Indinavir can be increased when it is combined with Conivaptan.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be decreased when it is combined with Indinavir.
Cortisone acetateThe serum concentration of Cortisone acetate can be increased when it is combined with Indinavir.
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Indinavir.
CrizotinibThe metabolism of Indinavir can be decreased when combined with Crizotinib.
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be increased when it is combined with Indinavir.
CyclophosphamideThe risk or severity of adverse effects can be increased when Indinavir is combined with Cyclophosphamide.
CyclophosphamideThe serum concentration of Indinavir can be increased when it is combined with Cyclophosphamide.
CyclosporineThe metabolism of Indinavir can be decreased when combined with Cyclosporine.
CyclosporineThe serum concentration of Cyclosporine can be decreased when it is combined with Indinavir.
CytarabineThe metabolism of Cytarabine can be decreased when combined with Indinavir.
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be decreased when it is combined with Indinavir.
DabrafenibThe serum concentration of Indinavir can be decreased when it is combined with Dabrafenib.
DaclatasvirThe serum concentration of Daclatasvir can be increased when it is combined with Indinavir.
DactinomycinThe serum concentration of Dactinomycin can be decreased when it is combined with Indinavir.
DactinomycinThe serum concentration of Indinavir can be increased when it is combined with Dactinomycin.
DantroleneThe metabolism of Dantrolene can be decreased when combined with Indinavir.
DapagliflozinThe serum concentration of Dapagliflozin can be decreased when it is combined with Indinavir.
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Indinavir.
DapsoneThe metabolism of Dapsone can be decreased when combined with Indinavir.
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Indinavir.
DarunavirThe metabolism of Darunavir can be decreased when combined with Indinavir.
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Indinavir.
DasatinibThe serum concentration of Indinavir can be increased when it is combined with Dasatinib.
DasatinibThe serum concentration of Dasatinib can be decreased when it is combined with Indinavir.
DaunorubicinThe serum concentration of Daunorubicin can be decreased when it is combined with Indinavir.
DebrisoquinThe serum concentration of Debrisoquin can be decreased when it is combined with Indinavir.
DeferasiroxThe serum concentration of Indinavir can be decreased when it is combined with Deferasirox.
DehydroepiandrosteroneThe serum concentration of Dehydroepiandrosterone can be increased when it is combined with Indinavir.
dehydroepiandrosterone sulfateThe serum concentration of dehydroepiandrosterone sulfate can be increased when it is combined with Indinavir.
DelavirdineThe metabolism of Indinavir can be decreased when combined with Delavirdine.
DesipramineThe serum concentration of Desipramine can be increased when it is combined with Indinavir.
DesloratadineThe serum concentration of Indinavir can be increased when it is combined with Desloratadine.
DesoximetasoneThe serum concentration of Desoximetasone can be increased when it is combined with Indinavir.
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be increased when it is combined with Indinavir.
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Indinavir.
DexamethasoneThe serum concentration of Indinavir can be decreased when it is combined with Dexamethasone.
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be increased when it is combined with Indinavir.
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Indinavir.
DexmethylphenidateThe metabolism of Dexmethylphenidate can be decreased when combined with Indinavir.
DextroamphetamineThe metabolism of Dextroamphetamine can be decreased when combined with Indinavir.
DextromethorphanThe serum concentration of Indinavir can be increased when it is combined with Dextromethorphan.
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Indinavir.
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Indinavir.
DiazepamThe serum concentration of Diazepam can be decreased when it is combined with Indinavir.
DiclofenacThe serum concentration of Indinavir can be increased when it is combined with Diclofenac.
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Indinavir.
DicoumarolThe metabolism of Dicoumarol can be decreased when combined with Indinavir.
DidanosineThe serum concentration of Indinavir can be decreased when it is combined with Didanosine.
DienogestThe serum concentration of Dienogest can be increased when it is combined with Indinavir.
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be decreased when it is combined with Indinavir.
DiflorasoneThe serum concentration of Diflorasone can be increased when it is combined with Indinavir.
DifluocortoloneThe serum concentration of Difluocortolone can be increased when it is combined with Indinavir.
DifluprednateThe serum concentration of Difluprednate can be increased when it is combined with Indinavir.
DigitoxinThe serum concentration of Digitoxin can be decreased when it is combined with Indinavir.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Indinavir.
DigoxinThe serum concentration of Indinavir can be decreased when it is combined with Digoxin.
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Indinavir.
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Indinavir.
DihydroergotamineThe metabolism of Indinavir can be decreased when combined with Dihydroergotamine.
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Indinavir.
DiltiazemThe metabolism of Indinavir can be decreased when combined with Diltiazem.
DiltiazemThe serum concentration of Diltiazem can be decreased when it is combined with Indinavir.
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Indinavir.
DipyridamoleThe serum concentration of Dipyridamole can be decreased when it is combined with Indinavir.
DipyridamoleThe serum concentration of Indinavir can be increased when it is combined with Dipyridamole.
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Indinavir.
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Indinavir.
DocetaxelThe serum concentration of Docetaxel can be decreased when it is combined with Indinavir.
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Indinavir.
DolasetronThe metabolism of Dolasetron can be decreased when combined with Indinavir.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Indinavir.
DonepezilThe metabolism of Donepezil can be decreased when combined with Indinavir.
DopamineThe metabolism of Dopamine can be decreased when combined with Indinavir.
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Indinavir.
DosulepinThe serum concentration of Dosulepin can be increased when it is combined with Indinavir.
DoxazosinThe serum concentration of Indinavir can be increased when it is combined with Doxazosin.
DoxazosinThe metabolism of Doxazosin can be decreased when combined with Indinavir.
DoxepinThe serum concentration of Indinavir can be decreased when it is combined with Doxepin.
DoxepinThe serum concentration of Doxepin can be increased when it is combined with Indinavir.
DoxorubicinThe serum concentration of Doxorubicin can be decreased when it is combined with Indinavir.
DoxycyclineThe metabolism of Indinavir can be decreased when combined with Doxycycline.
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Indinavir.
DronedaroneThe serum concentration of Dronedarone can be increased when it is combined with Indinavir.
DronedaroneThe metabolism of Indinavir can be decreased when combined with Dronedarone.
DrospirenoneThe serum concentration of Drospirenone can be increased when it is combined with Indinavir.
DulaglutideThe therapeutic efficacy of Dulaglutide can be decreased when used in combination with Indinavir.
DuloxetineThe metabolism of Duloxetine can be decreased when combined with Indinavir.
DutasterideThe serum concentration of Dutasteride can be increased when it is combined with Indinavir.
DyphyllineThe serum concentration of Dyphylline can be decreased when it is combined with Indinavir.
EdoxabanThe serum concentration of Edoxaban can be decreased when it is combined with Indinavir.
EfavirenzThe serum concentration of Indinavir can be decreased when it is combined with Efavirenz.
EfavirenzThe metabolism of Efavirenz can be decreased when combined with Indinavir.
ElbasvirThe serum concentration of Indinavir can be increased when it is combined with Elbasvir.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Indinavir.
EliglustatThe metabolism of Eliglustat can be decreased when combined with Indinavir.
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Indinavir.
EmpagliflozinThe therapeutic efficacy of Empagliflozin can be decreased when used in combination with Indinavir.
EnalaprilThe metabolism of Enalapril can be decreased when combined with Indinavir.
EnalaprilThe serum concentration of Indinavir can be increased when it is combined with Enalapril.
EncainideThe metabolism of Encainide can be decreased when combined with Indinavir.
EnclomipheneThe metabolism of Enclomiphene can be decreased when combined with Indinavir.
EnfuvirtideThe serum concentration of Enfuvirtide can be increased when it is combined with Indinavir.
EnzalutamideThe serum concentration of Enzalutamide can be increased when it is combined with Indinavir.
EpinastineThe serum concentration of Indinavir can be decreased when it is combined with Epinastine.
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Indinavir.
EpoprostenolThe metabolism of Epoprostenol can be decreased when combined with Indinavir.
EquileninThe serum concentration of Equilenin can be increased when it is combined with Indinavir.
EquilinThe serum concentration of Equilin can be increased when it is combined with Indinavir.
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Indinavir.
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Indinavir.
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Indinavir.
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Indinavir.
ErlotinibThe serum concentration of Erlotinib can be decreased when it is combined with Indinavir.
ErythromycinThe metabolism of Indinavir can be decreased when combined with Erythromycin.
ErythromycinThe serum concentration of Erythromycin can be decreased when it is combined with Indinavir.
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Indinavir.
Eslicarbazepine acetateThe serum concentration of Indinavir can be decreased when it is combined with Eslicarbazepine acetate.
EsmirtazapineThe serum concentration of Esmirtazapine can be increased when it is combined with Indinavir.
EsomeprazoleThe serum concentration of Indinavir can be decreased when it is combined with Esomeprazole.
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Indinavir.
EstazolamThe serum concentration of Estazolam can be increased when it is combined with Indinavir.
EstradiolThe serum concentration of Estradiol can be decreased when it is combined with Indinavir.
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Indinavir.
EstramustineThe metabolism of Estramustine can be decreased when combined with Indinavir.
EstramustineThe serum concentration of Indinavir can be increased when it is combined with Estramustine.
EstriolThe serum concentration of Estriol can be decreased when it is combined with Indinavir.
EstroneThe serum concentration of Estrone can be decreased when it is combined with Indinavir.
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Indinavir.
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Indinavir.
EthanolThe metabolism of Ethanol can be decreased when combined with Indinavir.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Indinavir.
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Indinavir.
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Indinavir.
EtizolamThe serum concentration of Etizolam can be increased when it is combined with Indinavir.
EtodolacThe metabolism of Etodolac can be decreased when combined with Indinavir.
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Indinavir.
EtoposideThe serum concentration of Etoposide can be decreased when it is combined with Indinavir.
EtoposideThe serum concentration of Indinavir can be increased when it is combined with Etoposide.
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Indinavir.
EtravirineThe serum concentration of Etravirine can be decreased when it is combined with Indinavir.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Indinavir.
ExemestaneThe metabolism of Exemestane can be decreased when combined with Indinavir.
ExenatideThe therapeutic efficacy of Exenatide can be decreased when used in combination with Indinavir.
EzetimibeThe serum concentration of Ezetimibe can be decreased when it is combined with Indinavir.
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Indinavir.
FamotidineThe serum concentration of Indinavir can be decreased when it is combined with Famotidine.
FamotidineThe metabolism of Famotidine can be decreased when combined with Indinavir.
FelbamateThe metabolism of Felbamate can be decreased when combined with Indinavir.
FelodipineThe metabolism of Felodipine can be decreased when combined with Indinavir.
FelodipineThe serum concentration of Indinavir can be increased when it is combined with Felodipine.
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Indinavir.
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Indinavir.
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Indinavir.
FexofenadineThe serum concentration of Fexofenadine can be decreased when it is combined with Indinavir.
FexofenadineThe serum concentration of Indinavir can be increased when it is combined with Fexofenadine.
FidaxomicinThe serum concentration of Fidaxomicin can be decreased when it is combined with Indinavir.
FidaxomicinThe serum concentration of Indinavir can be increased when it is combined with Fidaxomicin.
FinasterideThe metabolism of Finasteride can be decreased when combined with Indinavir.
FingolimodThe metabolism of Fingolimod can be decreased when combined with Indinavir.
FlecainideThe metabolism of Flecainide can be decreased when combined with Indinavir.
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Indinavir.
FluconazoleThe metabolism of Indinavir can be decreased when combined with Fluconazole.
FludrocortisoneThe serum concentration of Fludrocortisone can be increased when it is combined with Indinavir.
FlumethasoneThe serum concentration of Flumethasone can be increased when it is combined with Indinavir.
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Indinavir.
FlunisolideThe serum concentration of Flunisolide can be increased when it is combined with Indinavir.
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Indinavir.
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be increased when it is combined with Indinavir.
FluocinonideThe serum concentration of Fluocinonide can be increased when it is combined with Indinavir.
FluocortoloneThe serum concentration of Fluocortolone can be increased when it is combined with Indinavir.
FluorometholoneThe serum concentration of Fluorometholone can be increased when it is combined with Indinavir.
FluoxetineThe serum concentration of Indinavir can be increased when it is combined with Fluoxetine.
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Indinavir.
FlupentixolThe serum concentration of Indinavir can be increased when it is combined with Flupentixol.
FluphenazineThe serum concentration of Indinavir can be increased when it is combined with Fluphenazine.
FluphenazineThe metabolism of Fluphenazine can be decreased when combined with Indinavir.
FluprednideneThe serum concentration of Fluprednidene can be increased when it is combined with Indinavir.
FluprednisoloneThe serum concentration of Fluprednisolone can be increased when it is combined with Indinavir.
FlurandrenolideThe serum concentration of Flurandrenolide can be increased when it is combined with Indinavir.
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Indinavir.
FlurazepamThe serum concentration of Indinavir can be increased when it is combined with Flurazepam.
FlurbiprofenThe metabolism of Flurbiprofen can be decreased when combined with Indinavir.
FlutamideThe metabolism of Flutamide can be decreased when combined with Indinavir.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be decreased when it is combined with Indinavir.
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be increased when it is combined with Indinavir.
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Indinavir.
FluvoxamineThe metabolism of Indinavir can be decreased when combined with Fluvoxamine.
FormoterolThe metabolism of Formoterol can be decreased when combined with Indinavir.
FosamprenavirThe metabolism of Indinavir can be decreased when combined with Fosamprenavir.
FosaprepitantThe serum concentration of Indinavir can be increased when it is combined with Fosaprepitant.
FosphenytoinThe metabolism of Indinavir can be increased when combined with Fosphenytoin.
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Indinavir.
Fusidic AcidThe serum concentration of Indinavir can be increased when it is combined with Fusidic Acid.
GalantamineThe metabolism of Galantamine can be decreased when combined with Indinavir.
GarlicThe serum concentration of Indinavir can be decreased when it is combined with Garlic.
GavestinelThe metabolism of Gavestinel can be decreased when combined with Indinavir.
GefitinibThe serum concentration of Gefitinib can be decreased when it is combined with Indinavir.
GefitinibThe serum concentration of Indinavir can be increased when it is combined with Gefitinib.
GemcitabineThe serum concentration of Gemcitabine can be decreased when it is combined with Indinavir.
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Indinavir.
GenisteinThe serum concentration of Indinavir can be increased when it is combined with Genistein.
GlibornurideThe therapeutic efficacy of Glibornuride can be decreased when used in combination with Indinavir.
GliclazideThe therapeutic efficacy of Gliclazide can be decreased when used in combination with Indinavir.
GlimepirideThe therapeutic efficacy of Glimepiride can be decreased when used in combination with Indinavir.
GlipizideThe therapeutic efficacy of Glipizide can be decreased when used in combination with Indinavir.
GliquidoneThe therapeutic efficacy of Gliquidone can be decreased when used in combination with Indinavir.
GlucosamineThe metabolism of Glucosamine can be decreased when combined with Indinavir.
GlyburideThe therapeutic efficacy of Glyburide can be decreased when used in combination with Indinavir.
GlyburideThe serum concentration of Indinavir can be increased when it is combined with Glyburide.
GlycerolThe serum concentration of Indinavir can be increased when it is combined with Glycerol.
Gramicidin DThe serum concentration of Indinavir can be increased when it is combined with Gramicidin D.
GranisetronThe metabolism of Granisetron can be decreased when combined with Indinavir.
GrazoprevirThe serum concentration of Grazoprevir can be decreased when it is combined with Indinavir.
GrepafloxacinThe serum concentration of Grepafloxacin can be decreased when it is combined with Indinavir.
GrepafloxacinThe serum concentration of Indinavir can be increased when it is combined with Grepafloxacin.
GuanfacineThe metabolism of Guanfacine can be decreased when combined with Indinavir.
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Indinavir.
HaloperidolThe serum concentration of Haloperidol can be decreased when it is combined with Indinavir.
HaloperidolThe serum concentration of Indinavir can be increased when it is combined with Haloperidol.
HalothaneThe metabolism of Halothane can be decreased when combined with Indinavir.
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Indinavir.
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Indinavir.
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Indinavir.
HydrocortisoneThe serum concentration of Hydrocortisone can be decreased when it is combined with Indinavir.
HydrocortisoneThe serum concentration of Indinavir can be increased when it is combined with Hydrocortisone.
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Indinavir.
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Indinavir.
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Indinavir.
IbuprofenThe serum concentration of Ibuprofen can be decreased when it is combined with Indinavir.
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Indinavir.
IdelalisibThe serum concentration of Indinavir can be increased when it is combined with Idelalisib.
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Indinavir resulting in a loss in efficacy.
IloperidoneThe metabolism of Iloperidone can be decreased when combined with Indinavir.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Indinavir.
ImatinibThe metabolism of Indinavir can be decreased when combined with Imatinib.
ImidafenacinThe serum concentration of Imidafenacin can be increased when it is combined with Indinavir.
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Indinavir.
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Indinavir.
IndacaterolThe serum concentration of Indacaterol can be decreased when it is combined with Indinavir.
IndapamideThe metabolism of Indapamide can be decreased when combined with Indinavir.
indisulamThe metabolism of indisulam can be decreased when combined with Indinavir.
IndomethacinThe serum concentration of Indomethacin can be decreased when it is combined with Indinavir.
IndomethacinThe serum concentration of Indinavir can be increased when it is combined with Indomethacin.
Insulin AspartThe therapeutic efficacy of Insulin Aspart can be decreased when used in combination with Indinavir.
Insulin DetemirThe therapeutic efficacy of Insulin Detemir can be decreased when used in combination with Indinavir.
Insulin GlargineThe therapeutic efficacy of Insulin Glargine can be decreased when used in combination with Indinavir.
Insulin GlulisineThe therapeutic efficacy of Insulin Glulisine can be decreased when used in combination with Indinavir.
Insulin LisproThe therapeutic efficacy of Insulin Lispro can be decreased when used in combination with Indinavir.
Insulin PorkThe therapeutic efficacy of Insulin Pork can be decreased when used in combination with Indinavir.
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Indinavir.
IrbesartanThe metabolism of Irbesartan can be decreased when combined with Indinavir.
IrinotecanThe serum concentration of the active metabolites of Irinotecan can be increased when Irinotecan is used in combination with Indinavir.
IsavuconazoniumThe serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Indinavir.
IsavuconazoniumThe metabolism of Indinavir can be decreased when combined with Isavuconazonium.
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Indinavir.
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Indinavir.
IsradipineThe metabolism of Indinavir can be decreased when combined with Isradipine.
ItraconazoleThe metabolism of Itraconazole can be decreased when combined with Indinavir.
ItraconazoleThe serum concentration of Indinavir can be increased when it is combined with Itraconazole.
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Indinavir.
IvacaftorThe serum concentration of Indinavir can be increased when it is combined with Ivacaftor.
IvermectinThe serum concentration of Ivermectin can be decreased when it is combined with Indinavir.
IvermectinThe serum concentration of Indinavir can be increased when it is combined with Ivermectin.
IxabepiloneThe serum concentration of Ixabepilone can be increased when it is combined with Indinavir.
IxazomibThe metabolism of Ixazomib can be decreased when combined with Indinavir.
KetamineThe serum concentration of Indinavir can be increased when it is combined with Ketamine.
KetamineThe metabolism of Ketamine can be decreased when combined with Indinavir.
KetazolamThe serum concentration of Ketazolam can be decreased when it is combined with Indinavir.
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Indinavir.
KetoconazoleThe serum concentration of Ketoconazole can be decreased when it is combined with Indinavir.
KetoconazoleThe serum concentration of Indinavir can be increased when it is combined with Ketoconazole.
KetoprofenThe metabolism of Ketoprofen can be decreased when combined with Indinavir.
LabetalolThe metabolism of Labetalol can be decreased when combined with Indinavir.
LacosamideThe serum concentration of Lacosamide can be increased when it is combined with Indinavir.
LamivudineThe serum concentration of Lamivudine can be decreased when it is combined with Indinavir.
LamotrigineThe serum concentration of Lamotrigine can be decreased when it is combined with Indinavir.
LansoprazoleThe serum concentration of Indinavir can be decreased when it is combined with Lansoprazole.
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Indinavir.
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Indinavir.
LedipasvirThe serum concentration of Ledipasvir can be decreased when it is combined with Indinavir.
LeflunomideThe metabolism of Leflunomide can be decreased when combined with Indinavir.
LenalidomideThe serum concentration of Lenalidomide can be decreased when it is combined with Indinavir.
LenvatinibThe serum concentration of Lenvatinib can be decreased when it is combined with Indinavir.
LercanidipineThe serum concentration of Lercanidipine can be increased when it is combined with Indinavir.
LesinuradThe metabolism of Lesinurad can be decreased when combined with Indinavir.
LetrozoleThe metabolism of Letrozole can be decreased when combined with Indinavir.
LevetiracetamThe serum concentration of Levetiracetam can be decreased when it is combined with Indinavir.
LevobupivacaineThe serum concentration of Levobupivacaine can be increased when it is combined with Indinavir.
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Indinavir.
LevodopaThe metabolism of Levodopa can be decreased when combined with Indinavir.
LevofloxacinThe serum concentration of Levofloxacin can be decreased when it is combined with Indinavir.
LevofloxacinThe serum concentration of Indinavir can be increased when it is combined with Levofloxacin.
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Indinavir.
LevomilnacipranThe serum concentration of Levomilnacipran can be decreased when it is combined with Indinavir.
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Indinavir.
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Indinavir.
LevothyroxineThe serum concentration of Indinavir can be decreased when it is combined with Levothyroxine.
LicofeloneThe metabolism of Licofelone can be decreased when combined with Indinavir.
LidocaineThe serum concentration of Indinavir can be increased when it is combined with Lidocaine.
LidocaineThe metabolism of Lidocaine can be decreased when combined with Indinavir.
LinagliptinThe therapeutic efficacy of Linagliptin can be decreased when used in combination with Indinavir.
LiothyronineThe serum concentration of Indinavir can be decreased when it is combined with Liothyronine.
LiotrixThe serum concentration of Indinavir can be decreased when it is combined with Liotrix.
LiraglutideThe therapeutic efficacy of Liraglutide can be decreased when used in combination with Indinavir.
LisinoprilThe serum concentration of Indinavir can be increased when it is combined with Lisinopril.
LisurideThe metabolism of Lisuride can be decreased when combined with Indinavir.
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Indinavir.
LomustineThe metabolism of Lomustine can be decreased when combined with Indinavir.
LoperamideThe serum concentration of Loperamide can be decreased when it is combined with Indinavir.
LoperamideThe serum concentration of Indinavir can be increased when it is combined with Loperamide.
LopinavirThe metabolism of Lopinavir can be decreased when combined with Indinavir.
LopinavirThe serum concentration of Indinavir can be increased when it is combined with Lopinavir.
LoratadineThe serum concentration of Indinavir can be increased when it is combined with Loratadine.
LoratadineThe metabolism of Loratadine can be decreased when combined with Indinavir.
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Indinavir.
LornoxicamThe metabolism of Lornoxicam can be decreased when combined with Indinavir.
LosartanThe serum concentration of Losartan can be decreased when it is combined with Indinavir.
LosartanThe serum concentration of Indinavir can be increased when it is combined with Losartan.
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Indinavir.
LovastatinThe metabolism of Indinavir can be decreased when combined with Lovastatin.
LuliconazoleThe serum concentration of Indinavir can be increased when it is combined with Luliconazole.
LumacaftorThe serum concentration of Indinavir can be decreased when it is combined with Lumacaftor.
LumefantrineThe serum concentration of Lumefantrine can be increased when it is combined with Indinavir.
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Indinavir.
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Indinavir.
MacitentanThe serum concentration of Macitentan can be increased when it is combined with Indinavir.
MannitolThe serum concentration of Mannitol can be decreased when it is combined with Indinavir.
MaprotilineThe serum concentration of Indinavir can be increased when it is combined with Maprotiline.
MaprotilineThe metabolism of Maprotiline can be decreased when combined with Indinavir.
MaravirocThe serum concentration of Maraviroc can be increased when it is combined with Indinavir.
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Indinavir.
MebendazoleThe serum concentration of Indinavir can be increased when it is combined with Mebendazole.
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be increased when it is combined with Indinavir.
MedrysoneThe serum concentration of Medrysone can be increased when it is combined with Indinavir.
Mefenamic acidThe metabolism of Mefenamic acid can be decreased when combined with Indinavir.
MefloquineThe metabolism of Mefloquine can be decreased when combined with Indinavir.
MefloquineThe serum concentration of Indinavir can be increased when it is combined with Mefloquine.
Megestrol acetateThe serum concentration of Indinavir can be increased when it is combined with Megestrol acetate.
MelatoninThe metabolism of Melatonin can be decreased when combined with Indinavir.
MelengestrolThe serum concentration of Melengestrol can be increased when it is combined with Indinavir.
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Indinavir.
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Indinavir.
MeprobamateThe serum concentration of Indinavir can be increased when it is combined with Meprobamate.
MeprobamateThe metabolism of Meprobamate can be decreased when combined with Indinavir.
MequitazineThe metabolism of Mequitazine can be decreased when combined with Indinavir.
MesoridazineThe metabolism of Mesoridazine can be decreased when combined with Indinavir.
MestranolThe metabolism of Mestranol can be decreased when combined with Indinavir.
MetforminThe therapeutic efficacy of Metformin can be decreased when used in combination with Indinavir.
MethadoneThe serum concentration of Indinavir can be increased when it is combined with Methadone.
MethadoneThe metabolism of Methadone can be decreased when combined with Indinavir.
MethamphetamineThe metabolism of Methamphetamine can be decreased when combined with Indinavir.
MethanthelineThe serum concentration of Indinavir can be decreased when it is combined with Methantheline.
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Indinavir.
MethotrexateThe serum concentration of Methotrexate can be decreased when it is combined with Indinavir.
MethotrimeprazineThe metabolism of Methotrimeprazine can be decreased when combined with Indinavir.
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Indinavir.
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Indinavir.
MethsuximideThe metabolism of Methsuximide can be decreased when combined with Indinavir.
MethylphenidateThe metabolism of Methylphenidate can be decreased when combined with Indinavir.
MethylphenobarbitalThe metabolism of Methylphenobarbital can be decreased when combined with Indinavir.
MethylprednisoloneThe serum concentration of Methylprednisolone can be decreased when it is combined with Indinavir.
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Indinavir.
MethyprylonThe metabolism of Methyprylon can be decreased when combined with Indinavir.
MetiamideThe serum concentration of Indinavir can be decreased when it is combined with Metiamide.
MetoclopramideThe metabolism of Metoclopramide can be decreased when combined with Indinavir.
MetoprololThe serum concentration of Metoprolol can be decreased when it is combined with Indinavir.
MetoprololThe serum concentration of Indinavir can be increased when it is combined with Metoprolol.
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Indinavir.
MexiletineThe metabolism of Mexiletine can be decreased when combined with Indinavir.
MianserinThe metabolism of Mianserin can be decreased when combined with Indinavir.
MibefradilThe metabolism of Mibefradil can be decreased when combined with Indinavir.
MibefradilThe serum concentration of Indinavir can be increased when it is combined with Mibefradil.
MiconazoleThe metabolism of Miconazole can be decreased when combined with Indinavir.
MiconazoleThe serum concentration of Indinavir can be increased when it is combined with Miconazole.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Indinavir.
MidazolamThe serum concentration of Indinavir can be decreased when it is combined with Midazolam.
MifepristoneThe serum concentration of Mifepristone can be increased when it is combined with Indinavir.
MifepristoneThe metabolism of Indinavir can be decreased when combined with Mifepristone.
MiglitolThe therapeutic efficacy of Miglitol can be decreased when used in combination with Indinavir.
MiglustatThe therapeutic efficacy of Miglustat can be decreased when used in combination with Indinavir.
MinaprineThe metabolism of Minaprine can be decreased when combined with Indinavir.
MirabegronThe serum concentration of Mirabegron can be decreased when it is combined with Indinavir.
MirtazapineThe serum concentration of Mirtazapine can be increased when it is combined with Indinavir.
MitiglinideThe therapeutic efficacy of Mitiglinide can be decreased when used in combination with Indinavir.
MitomycinThe serum concentration of Indinavir can be increased when it is combined with Mitomycin.
MitotaneThe serum concentration of Indinavir can be decreased when it is combined with Mitotane.
MitoxantroneThe serum concentration of Mitoxantrone can be decreased when it is combined with Indinavir.
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Indinavir.
ModafinilThe serum concentration of Indinavir can be decreased when it is combined with Modafinil.
ModafinilThe metabolism of Modafinil can be decreased when combined with Indinavir.
MometasoneThe serum concentration of Mometasone can be increased when it is combined with Indinavir.
MontelukastThe metabolism of Montelukast can be decreased when combined with Indinavir.
MorphineThe serum concentration of Morphine can be decreased when it is combined with Indinavir.
MorphineThe serum concentration of Indinavir can be increased when it is combined with Morphine.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be decreased when it is combined with Indinavir.
NadololThe serum concentration of Nadolol can be decreased when it is combined with Indinavir.
NafcillinThe serum concentration of Indinavir can be decreased when it is combined with Nafcillin.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Indinavir.
NaloxoneThe serum concentration of Naloxone can be decreased when it is combined with Indinavir.
NaltrexoneThe serum concentration of Indinavir can be increased when it is combined with Naltrexone.
NaproxenThe metabolism of Naproxen can be decreased when combined with Indinavir.
NaringeninThe serum concentration of Indinavir can be increased when it is combined with Naringenin.
NateglinideThe therapeutic efficacy of Nateglinide can be decreased when used in combination with Indinavir.
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Indinavir.
NefazodoneThe serum concentration of Indinavir can be decreased when it is combined with Nefazodone.
NefazodoneThe metabolism of Nefazodone can be decreased when combined with Indinavir.
NelfinavirThe serum concentration of Indinavir can be decreased when it is combined with Nelfinavir.
NeostigmineThe serum concentration of Indinavir can be increased when it is combined with Neostigmine.
NetupitantThe serum concentration of Indinavir can be increased when it is combined with Netupitant.
NetupitantThe metabolism of Netupitant can be decreased when combined with Indinavir.
NevirapineThe metabolism of Indinavir can be decreased when combined with Nevirapine.
NicardipineThe serum concentration of Nicardipine can be decreased when it is combined with Indinavir.
NicardipineThe serum concentration of Indinavir can be increased when it is combined with Nicardipine.
NicergolineThe metabolism of Nicergoline can be decreased when combined with Indinavir.
NiclosamideThe metabolism of Niclosamide can be decreased when combined with Indinavir.
NicotineThe metabolism of Nicotine can be decreased when combined with Indinavir.
NifedipineThe serum concentration of Nifedipine can be decreased when it is combined with Indinavir.
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Indinavir.
NilotinibThe metabolism of Indinavir can be decreased when combined with Nilotinib.
NilutamideThe metabolism of Nilutamide can be decreased when combined with Indinavir.
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Indinavir.
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Indinavir.
NintedanibThe serum concentration of Nintedanib can be decreased when it is combined with Indinavir.
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Indinavir.
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Indinavir.
NitrazepamThe serum concentration of Indinavir can be increased when it is combined with Nitrazepam.
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Indinavir.
NitrendipineThe serum concentration of Indinavir can be increased when it is combined with Nitrendipine.
NitrofuralThe metabolism of Nitrofural can be decreased when combined with Indinavir.
NizatidineThe serum concentration of Indinavir can be decreased when it is combined with Nizatidine.
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Indinavir.
NorethisteroneThe serum concentration of Indinavir can be decreased when it is combined with Norethisterone.
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Indinavir.
NortriptylineThe serum concentration of Nortriptyline can be increased when it is combined with Indinavir.
OlanzapineThe serum concentration of Indinavir can be decreased when it is combined with Olanzapine.
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Indinavir.
OlaparibThe metabolism of Indinavir can be decreased when combined with Olaparib.
OlodaterolThe metabolism of Olodaterol can be decreased when combined with Indinavir.
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Indinavir.
OmbitasvirThe serum concentration of Ombitasvir can be decreased when it is combined with Indinavir.
OmeprazoleThe serum concentration of Indinavir can be decreased when it is combined with Omeprazole.
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Indinavir.
OndansetronThe metabolism of Ondansetron can be decreased when combined with Indinavir.
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Indinavir.
OsimertinibThe serum concentration of Indinavir can be increased when it is combined with Osimertinib.
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Indinavir.
OxaprozinThe metabolism of Oxaprozin can be decreased when combined with Indinavir.
OxazepamThe metabolism of Oxazepam can be decreased when combined with Indinavir.
OxiconazoleThe metabolism of Oxiconazole can be decreased when combined with Indinavir.
OxybutyninThe serum concentration of Oxybutynin can be increased when it is combined with Indinavir.
OxycodoneThe metabolism of Oxycodone can be decreased when combined with Indinavir.
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Indinavir.
P-NitrophenolThe serum concentration of Indinavir can be increased when it is combined with P-Nitrophenol.
PaclitaxelThe serum concentration of Paclitaxel can be decreased when it is combined with Indinavir.
PaclitaxelThe serum concentration of Indinavir can be increased when it is combined with Paclitaxel.
PalbociclibThe serum concentration of Indinavir can be increased when it is combined with Palbociclib.
Palmitic AcidThe serum concentration of Indinavir can be increased when it is combined with Palmitic Acid.
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Indinavir.
PanobinostatThe serum concentration of Panobinostat can be decreased when it is combined with Indinavir.
PantoprazoleThe serum concentration of Indinavir can be decreased when it is combined with Pantoprazole.
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Indinavir.
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Indinavir.
ParamethasoneThe serum concentration of Paramethasone can be increased when it is combined with Indinavir.
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Indinavir.
ParicalcitolThe serum concentration of Paricalcitol can be increased when it is combined with Indinavir.
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Indinavir.
ParoxetineThe serum concentration of Indinavir can be increased when it is combined with Paroxetine.
ParoxetineThe metabolism of Paroxetine can be decreased when combined with Indinavir.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Indinavir.
PentamidineThe metabolism of Pentamidine can be decreased when combined with Indinavir.
PentobarbitalThe metabolism of Indinavir can be increased when combined with Pentobarbital.
PerampanelThe metabolism of Perampanel can be decreased when combined with Indinavir.
PergolideThe metabolism of Pergolide can be decreased when combined with Indinavir.
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Indinavir.
PerindoprilThe serum concentration of Indinavir can be increased when it is combined with Perindopril.
PermethrinThe metabolism of Permethrin can be decreased when combined with Indinavir.
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Indinavir.
PethidineThe metabolism of Pethidine can be decreased when combined with Indinavir.
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Indinavir.
PhenforminThe therapeutic efficacy of Phenformin can be decreased when used in combination with Indinavir.
PhenobarbitalThe serum concentration of Phenobarbital can be decreased when it is combined with Indinavir.
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Indinavir.
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Indinavir.
PhenylbutazoneThe metabolism of Phenylbutazone can be decreased when combined with Indinavir.
PhenytoinThe metabolism of Indinavir can be increased when combined with Phenytoin.
PhenytoinThe serum concentration of Phenytoin can be decreased when it is combined with Indinavir.
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Indinavir.
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Indinavir.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Indinavir.
PinacidilThe metabolism of Pinacidil can be decreased when combined with Indinavir.
PindololThe metabolism of Pindolol can be decreased when combined with Indinavir.
PioglitazoneThe therapeutic efficacy of Pioglitazone can be decreased when used in combination with Indinavir.
PiperazineThe metabolism of Piperazine can be decreased when combined with Indinavir.
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Indinavir.
PiroxicamThe metabolism of Piroxicam can be decreased when combined with Indinavir.
PitavastatinThe serum concentration of Pitavastatin can be decreased when it is combined with Indinavir.
Platelet Activating FactorThe serum concentration of Indinavir can be decreased when it is combined with Platelet Activating Factor.
PodofiloxThe metabolism of Podofilox can be decreased when combined with Indinavir.
PomalidomideThe serum concentration of Pomalidomide can be decreased when it is combined with Indinavir.
PonatinibThe serum concentration of Ponatinib can be decreased when it is combined with Indinavir.
PonatinibThe serum concentration of Indinavir can be increased when it is combined with Ponatinib.
PosaconazoleThe metabolism of Posaconazole can be decreased when combined with Indinavir.
PosaconazoleThe serum concentration of Indinavir can be increased when it is combined with Posaconazole.
PramlintideThe therapeutic efficacy of Pramlintide can be decreased when used in combination with Indinavir.
PranlukastThe serum concentration of Pranlukast can be increased when it is combined with Indinavir.
PrasugrelThe serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with Indinavir resulting in a loss in efficacy.
PravastatinThe serum concentration of Pravastatin can be decreased when it is combined with Indinavir.
PravastatinThe serum concentration of Indinavir can be increased when it is combined with Pravastatin.
PrazepamThe metabolism of Prazepam can be decreased when combined with Indinavir.
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Indinavir.
PrazosinThe serum concentration of Prazosin can be decreased when it is combined with Indinavir.
PrazosinThe serum concentration of Indinavir can be increased when it is combined with Prazosin.
PrednicarbateThe serum concentration of Prednicarbate can be increased when it is combined with Indinavir.
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Indinavir.
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Indinavir.
PregnenoloneThe serum concentration of Pregnenolone can be increased when it is combined with Indinavir.
PrimaquineThe metabolism of Primaquine can be decreased when combined with Indinavir.
PrimidoneThe metabolism of Indinavir can be increased when combined with Primidone.
ProbenecidThe serum concentration of Indinavir can be increased when it is combined with Probenecid.
ProcainamideThe metabolism of Procainamide can be decreased when combined with Indinavir.
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Indinavir.
ProgesteroneThe serum concentration of Progesterone can be decreased when it is combined with Indinavir.
ProguanilThe metabolism of Proguanil can be decreased when combined with Indinavir.
PromazineThe metabolism of Promazine can be decreased when combined with Indinavir.
PromethazineThe serum concentration of Indinavir can be increased when it is combined with Promethazine.
PromethazineThe metabolism of Promethazine can be decreased when combined with Indinavir.
PropafenoneThe serum concentration of Indinavir can be increased when it is combined with Propafenone.
PropofolThe metabolism of Propofol can be decreased when combined with Indinavir.
PropranololThe serum concentration of Propranolol can be decreased when it is combined with Indinavir.
PropranololThe serum concentration of Indinavir can be increased when it is combined with Propranolol.
ProtriptylineThe serum concentration of Protriptyline can be increased when it is combined with Indinavir.
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Indinavir.
PseudoephedrineThe metabolism of Pseudoephedrine can be decreased when combined with Indinavir.
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Indinavir.
QuazepamThe metabolism of Quazepam can be decreased when combined with Indinavir.
QuercetinThe serum concentration of Indinavir can be increased when it is combined with Quercetin.
QuetiapineThe serum concentration of Quetiapine can be decreased when it is combined with Indinavir.
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Indinavir.
QuinacrineThe serum concentration of Indinavir can be increased when it is combined with Quinacrine.
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Indinavir.
QuinineThe serum concentration of Quinine can be decreased when it is combined with Indinavir.
QuinineThe serum concentration of Indinavir can be increased when it is combined with Quinine.
RabeprazoleThe serum concentration of Indinavir can be decreased when it is combined with Rabeprazole.
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Indinavir.
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Indinavir.
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Indinavir.
RanitidineThe serum concentration of Indinavir can be decreased when it is combined with Ranitidine.
RanolazineThe serum concentration of Indinavir can be increased when it is combined with Ranolazine.
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Indinavir.
ReboxetineThe serum concentration of Indinavir can be increased when it is combined with Reboxetine.
RegorafenibThe serum concentration of Regorafenib can be increased when it is combined with Indinavir.
RemoxiprideThe metabolism of Remoxipride can be decreased when combined with Indinavir.
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Indinavir.
repinotanThe metabolism of repinotan can be decreased when combined with Indinavir.
ReserpineThe serum concentration of Reserpine can be decreased when it is combined with Indinavir.
RetapamulinThe serum concentration of Retapamulin can be increased when it is combined with Indinavir.
RifabutinThe serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Indinavir.
RifabutinThe metabolism of Indinavir can be increased when combined with Rifabutin.
RifampicinThe serum concentration of Indinavir can be decreased when it is combined with Rifampicin.
RifapentineThe metabolism of Indinavir can be increased when combined with Rifapentine.
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Indinavir.
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Indinavir.
RimexoloneThe serum concentration of Rimexolone can be increased when it is combined with Indinavir.
RimonabantThe metabolism of Rimonabant can be decreased when combined with Indinavir.
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Indinavir.
RisperidoneThe serum concentration of Risperidone can be decreased when it is combined with Indinavir.
RitonavirThe serum concentration of Ritonavir can be decreased when it is combined with Indinavir.
RivaroxabanThe serum concentration of Rivaroxaban can be decreased when it is combined with Indinavir.
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Indinavir.
RolapitantThe metabolism of Rolapitant can be decreased when combined with Indinavir.
RolapitantThe serum concentration of Indinavir can be increased when it is combined with Rolapitant.
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Indinavir.
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Indinavir.
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Indinavir.
RosiglitazoneThe therapeutic efficacy of Rosiglitazone can be decreased when used in combination with Indinavir.
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Indinavir.
RotigotineThe metabolism of Rotigotine can be decreased when combined with Indinavir.
Roxatidine acetateThe serum concentration of Indinavir can be decreased when it is combined with Roxatidine acetate.
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Indinavir.
RuxolitinibThe serum concentration of Ruxolitinib can be increased when it is combined with Indinavir.
Salicylic acidThe serum concentration of Salicylic acid can be decreased when it is combined with Indinavir.
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Indinavir.
SaquinavirThe serum concentration of Indinavir can be decreased when it is combined with Saquinavir.
SaxagliptinThe therapeutic efficacy of Saxagliptin can be decreased when used in combination with Indinavir.
ScopolamineThe serum concentration of Indinavir can be increased when it is combined with Scopolamine.
SelegilineThe serum concentration of Indinavir can be increased when it is combined with Selegiline.
SelegilineThe metabolism of Selegiline can be decreased when combined with Indinavir.
SelexipagThe serum concentration of Selexipag can be decreased when it is combined with Indinavir.
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Indinavir.
SertindoleThe metabolism of Sertindole can be decreased when combined with Indinavir.
SertralineThe serum concentration of Indinavir can be increased when it is combined with Sertraline.
SertralineThe metabolism of Sertraline can be decreased when combined with Indinavir.
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Indinavir.
SibutramineThe metabolism of Sibutramine can be decreased when combined with Indinavir.
SildenafilThe metabolism of Indinavir can be decreased when combined with Sildenafil.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Indinavir.
SiltuximabThe serum concentration of Indinavir can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Indinavir can be increased when it is combined with Simeprevir.
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Indinavir.
SirolimusThe metabolism of Sirolimus can be decreased when combined with Indinavir.
SirolimusThe serum concentration of Indinavir can be decreased when it is combined with Sirolimus.
SitagliptinThe therapeutic efficacy of Sitagliptin can be decreased when used in combination with Indinavir.
SitaxentanThe metabolism of Sitaxentan can be decreased when combined with Indinavir.
SofosbuvirThe serum concentration of Sofosbuvir can be decreased when it is combined with Indinavir.
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Indinavir.
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Indinavir.
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Indinavir.
SparfloxacinThe serum concentration of Sparfloxacin can be decreased when it is combined with Indinavir.
SparteineThe metabolism of Sparteine can be decreased when combined with Indinavir.
SphingosineThe serum concentration of Sphingosine can be decreased when it is combined with Indinavir.
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Indinavir.
SpironolactoneThe serum concentration of Indinavir can be increased when it is combined with Spironolactone.
St. John's WortThe metabolism of Indinavir can be increased when combined with St. John's Wort.
StaurosporineThe serum concentration of Indinavir can be increased when it is combined with Staurosporine.
StiripentolThe serum concentration of Indinavir can be increased when it is combined with Stiripentol.
StreptozocinThe serum concentration of Indinavir can be decreased when it is combined with Streptozocin.
SufentanilThe metabolism of Sufentanil can be decreased when combined with Indinavir.
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Indinavir.
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Indinavir.
SulfamoxoleThe metabolism of Sulfamoxole can be decreased when combined with Indinavir.
SulfinpyrazoneThe serum concentration of Indinavir can be increased when it is combined with Sulfinpyrazone.
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Indinavir.
SulfisoxazoleThe metabolism of Indinavir can be decreased when combined with Sulfisoxazole.
SulodexideThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Indinavir.
SumatriptanThe serum concentration of Indinavir can be increased when it is combined with Sumatriptan.
SunitinibThe metabolism of Sunitinib can be decreased when combined with Indinavir.
SunitinibThe serum concentration of Indinavir can be increased when it is combined with Sunitinib.
SuprofenThe metabolism of Suprofen can be decreased when combined with Indinavir.
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Indinavir.
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Indinavir.
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Indinavir.
TacrineThe serum concentration of Indinavir can be increased when it is combined with Tacrine.
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Indinavir.
TacrolimusThe serum concentration of Indinavir can be decreased when it is combined with Tacrolimus.
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Indinavir.
TAK-390MRThe serum concentration of Indinavir can be decreased when it is combined with TAK-390MR.
TamoxifenThe serum concentration of Tamoxifen can be decreased when it is combined with Indinavir.
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Indinavir.
TapentadolThe metabolism of Tapentadol can be decreased when combined with Indinavir.
TasimelteonThe serum concentration of Tasimelteon can be increased when it is combined with Indinavir.
TasosartanThe metabolism of Tasosartan can be decreased when combined with Indinavir.
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Indinavir.
Taurocholic AcidThe serum concentration of Taurocholic Acid can be decreased when it is combined with Indinavir.
Taurocholic AcidThe serum concentration of Indinavir can be increased when it is combined with Taurocholic Acid.
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Indinavir.
TegaserodThe metabolism of Tegaserod can be decreased when combined with Indinavir.
TelaprevirThe metabolism of Indinavir can be decreased when combined with Telaprevir.
TelaprevirThe serum concentration of Telaprevir can be decreased when it is combined with Indinavir.
TelithromycinThe metabolism of Telithromycin can be decreased when combined with Indinavir.
TelmisartanThe serum concentration of Indinavir can be increased when it is combined with Telmisartan.
TemazepamThe metabolism of Temazepam can be decreased when combined with Indinavir.
TemsirolimusThe serum concentration of Temsirolimus can be decreased when it is combined with Indinavir.
TemsirolimusThe serum concentration of Indinavir can be increased when it is combined with Temsirolimus.
TeniposideThe metabolism of Teniposide can be decreased when combined with Indinavir.
TenoxicamThe metabolism of Tenoxicam can be decreased when combined with Indinavir.
TerazosinThe serum concentration of Indinavir can be increased when it is combined with Terazosin.
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Indinavir.
TerfenadineThe serum concentration of Terfenadine can be increased when it is combined with Indinavir.
TesmilifeneThe serum concentration of Indinavir can be decreased when it is combined with Tesmilifene.
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Indinavir.
TestosteroneThe serum concentration of Indinavir can be increased when it is combined with Testosterone.
TestosteroneThe metabolism of Testosterone can be decreased when combined with Indinavir.
TetrabenazineThe metabolism of Tetrabenazine can be decreased when combined with Indinavir.
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Indinavir.
ThalidomideThe metabolism of Thalidomide can be decreased when combined with Indinavir.
TheophyllineThe serum concentration of Theophylline can be decreased when it is combined with Indinavir.
ThiamylalThe metabolism of Thiamylal can be decreased when combined with Indinavir.
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Indinavir.
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Indinavir.
TiagabineThe metabolism of Tiagabine can be decreased when combined with Indinavir.
TianeptineThe serum concentration of Tianeptine can be increased when it is combined with Indinavir.
TicagrelorThe serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Indinavir resulting in a loss in efficacy.
TicagrelorThe serum concentration of Indinavir can be increased when it is combined with Ticagrelor.
TiclopidineThe metabolism of Indinavir can be decreased when combined with Ticlopidine.
TimololThe serum concentration of Timolol can be decreased when it is combined with Indinavir.
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Indinavir.
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Indinavir.
TipranavirThe serum concentration of Indinavir can be decreased when it is combined with Tipranavir.
TipranavirThe metabolism of Tipranavir can be decreased when combined with Indinavir.
TixocortolThe serum concentration of Tixocortol can be increased when it is combined with Indinavir.
TocilizumabThe serum concentration of Indinavir can be decreased when it is combined with Tocilizumab.
TofacitinibThe metabolism of Tofacitinib can be decreased when combined with Indinavir.
TolazamideThe therapeutic efficacy of Tolazamide can be decreased when used in combination with Indinavir.
TolbutamideThe therapeutic efficacy of Tolbutamide can be decreased when used in combination with Indinavir.
TolterodineThe metabolism of Tolterodine can be decreased when combined with Indinavir.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Indinavir.
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Indinavir.
TorasemideThe metabolism of Torasemide can be decreased when combined with Indinavir.
ToremifeneThe risk or severity of adverse effects can be increased when Indinavir is combined with Toremifene.
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Indinavir.
TramadolThe therapeutic efficacy of Tramadol can be decreased when used in combination with Indinavir.
Trastuzumab emtansineThe serum concentration of the active metabolites of Trastuzumab emtansine can be increased when Trastuzumab emtansine is used in combination with Indinavir.
TrazodoneThe serum concentration of Indinavir can be decreased when it is combined with Trazodone.
TrazodoneThe metabolism of Trazodone can be decreased when combined with Indinavir.
TreprostinilThe metabolism of Treprostinil can be decreased when combined with Indinavir.
TretinoinThe metabolism of Tretinoin can be decreased when combined with Indinavir.
TriamcinoloneThe serum concentration of Triamcinolone can be increased when it is combined with Indinavir.
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Indinavir.
TrifluoperazineThe serum concentration of Indinavir can be increased when it is combined with Trifluoperazine.
TriflupromazineThe serum concentration of Indinavir can be increased when it is combined with Triflupromazine.
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Indinavir.
TrimethoprimThe serum concentration of Indinavir can be decreased when it is combined with Trimethoprim.
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Indinavir.
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Indinavir.
TroglitazoneThe therapeutic efficacy of Troglitazone can be decreased when used in combination with Indinavir.
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Indinavir.
TroleandomycinThe serum concentration of Indinavir can be increased when it is combined with Troleandomycin.
UdenafilThe metabolism of Udenafil can be decreased when combined with Indinavir.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Indinavir.
UmeclidiniumThe serum concentration of Umeclidinium can be decreased when it is combined with Indinavir.
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Indinavir.
Valproic AcidThe metabolism of Valproic Acid can be decreased when combined with Indinavir.
ValsartanThe metabolism of Valsartan can be decreased when combined with Indinavir.
VandetanibThe metabolism of Vandetanib can be decreased when combined with Indinavir.
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Indinavir.
VardenafilThe serum concentration of Vardenafil can be increased when it is combined with Indinavir.
VecuroniumThe serum concentration of Vecuronium can be decreased when it is combined with Indinavir.
VemurafenibThe serum concentration of Vemurafenib can be increased when it is combined with Indinavir.
VenlafaxineThe serum concentration of Indinavir can be decreased when it is combined with Venlafaxine.
VerapamilThe metabolism of Indinavir can be decreased when combined with Verapamil.
VerapamilThe serum concentration of Verapamil can be decreased when it is combined with Indinavir.
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Indinavir.
VilanterolThe metabolism of Vilanterol can be decreased when combined with Indinavir.
VilazodoneThe metabolism of Vilazodone can be decreased when combined with Indinavir.
VildagliptinThe therapeutic efficacy of Vildagliptin can be decreased when used in combination with Indinavir.
VinblastineThe serum concentration of Vinblastine can be decreased when it is combined with Indinavir.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Indinavir.
VincristineThe serum concentration of Indinavir can be decreased when it is combined with Vincristine.
VindesineThe serum concentration of Vindesine can be increased when it is combined with Indinavir.
VinorelbineThe serum concentration of Indinavir can be increased when it is combined with Vinorelbine.
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Indinavir.
VismodegibThe serum concentration of Vismodegib can be decreased when it is combined with Indinavir.
VogliboseThe therapeutic efficacy of Voglibose can be decreased when used in combination with Indinavir.
VorapaxarThe serum concentration of Vorapaxar can be increased when it is combined with Indinavir.
VoriconazoleThe metabolism of Indinavir can be decreased when combined with Voriconazole.
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Indinavir.
WarfarinThe metabolism of Warfarin can be decreased when combined with Indinavir.
XimelagatranThe metabolism of Ximelagatran can be decreased when combined with Indinavir.
YohimbineThe metabolism of Yohimbine can be decreased when combined with Indinavir.
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Indinavir.
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Indinavir.
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Indinavir.
ZaltoprofenThe metabolism of Zaltoprofen can be decreased when combined with Indinavir.
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Indinavir.
ZileutonThe metabolism of Zileuton can be decreased when combined with Indinavir.
ZimelidineThe serum concentration of Indinavir can be increased when it is combined with Zimelidine.
ZiprasidoneThe metabolism of Indinavir can be decreased when combined with Ziprasidone.
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Indinavir.
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Indinavir.
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Indinavir.
ZopicloneThe metabolism of Zopiclone can be decreased when combined with Indinavir.
ZuclopenthixolThe metabolism of Zuclopenthixol can be decreased when combined with Indinavir.
Food Interactions
  • Avoid excessive or chronic alcohol use.
  • Avoid taking with grapefruit juice
  • Take on empty stomach: 1 hour before or 2 hours after meals.
  • Take with a full glass of water.

Targets

Kind
Protein
Organism
Human immunodeficiency virus 1
Pharmacological action
yes
Actions
inhibitor
General Function:
Aspartic-type endopeptidase activity
Specific Function:
Not Available
Gene Name:
pol
Uniprot ID:
Q72874
Molecular Weight:
10778.7 Da
References
  1. Wittayanarakul K, Hannongbua S, Feig M: Accurate prediction of protonation state as a prerequisite for reliable MM-PB(GB)SA binding free energy calculations of HIV-1 protease inhibitors. J Comput Chem. 2008 Apr 15;29(5):673-85. [PubMed:17849388 ]
  2. Dandache S, Sevigny G, Yelle J, Stranix BR, Parkin N, Schapiro JM, Wainberg MA, Wu JJ: In vitro antiviral activity and cross-resistance profile of PL-100, a novel protease inhibitor of human immunodeficiency virus type 1. Antimicrob Agents Chemother. 2007 Nov;51(11):4036-43. Epub 2007 Jul 16. [PubMed:17638694 ]
  3. Hoetelmans RM, Meenhorst PL, Mulder JW, Burger DM, Koks CH, Beijnen JH: Clinical pharmacology of HIV protease inhibitors: focus on saquinavir, indinavir, and ritonavir. Pharm World Sci. 1997 Aug;19(4):159-75. [PubMed:9297727 ]
  4. Stein DS, Fish DG, Bilello JA, Preston SL, Martineau GL, Drusano GL: A 24-week open-label phase I/II evaluation of the HIV protease inhibitor MK-639 (indinavir). AIDS. 1996 May;10(5):485-92. [PubMed:8724039 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Ekins S, Bravi G, Wikel JH, Wrighton SA: Three-dimensional-quantitative structure activity relationship analysis of cytochrome P-450 3A4 substrates. J Pharmacol Exp Ther. 1999 Oct;291(1):424-33. [PubMed:10490933 ]
  4. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitorinducer
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Perloff MD, von Moltke LL, Fahey JM, Daily JP, Greenblatt DJ: Induction of P-glycoprotein expression by HIV protease inhibitors in cell culture. AIDS. 2000 Jun 16;14(9):1287-9. [PubMed:10894301 ]
  2. Choo EF, Leake B, Wandel C, Imamura H, Wood AJ, Wilkinson GR, Kim RB: Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes. Drug Metab Dispos. 2000 Jun;28(6):655-60. [PubMed:10820137 ]
  3. Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. [PubMed:11602674 ]
  4. Yamazaki M, Neway WE, Ohe T, Chen I, Rowe JF, Hochman JH, Chiba M, Lin JH: In vitro substrate identification studies for p-glycoprotein-mediated transport: species difference and predictability of in vivo results. J Pharmacol Exp Ther. 2001 Mar;296(3):723-35. [PubMed:11181899 ]
  5. Kim RB, Fromm MF, Wandel C, Leake B, Wood AJ, Roden DM, Wilkinson GR: The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors. J Clin Invest. 1998 Jan 15;101(2):289-94. [PubMed:9435299 ]
  6. Hochman JH, Chiba M, Nishime J, Yamazaki M, Lin JH: Influence of P-glycoprotein on the transport and metabolism of indinavir in Caco-2 cells expressing cytochrome P-450 3A4. J Pharmacol Exp Ther. 2000 Jan;292(1):310-8. [PubMed:10604964 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Secondary active organic cation transmembrane transporter activity
Specific Function:
Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine...
Gene Name:
SLC22A1
Uniprot ID:
O15245
Molecular Weight:
61153.345 Da
References
  1. Zhang L, Gorset W, Washington CB, Blaschke TF, Kroetz DL, Giacomini KM: Interactions of HIV protease inhibitors with a human organic cation transporter in a mammalian expression system. Drug Metab Dispos. 2000 Mar;28(3):329-34. [PubMed:10681378 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Transporter activity
Specific Function:
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.
Gene Name:
ABCC1
Uniprot ID:
P33527
Molecular Weight:
171589.5 Da
References
  1. Olson DP, Scadden DT, D'Aquila RT, De Pasquale MP: The protease inhibitor ritonavir inhibits the functional activity of the multidrug resistance related-protein 1 (MRP-1). AIDS. 2002 Sep 6;16(13):1743-7. [PubMed:12218384 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.
Gene Name:
SLCO1A2
Uniprot ID:
P46721
Molecular Weight:
74144.105 Da
References
  1. Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB: OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos. 1999 Aug;27(8):866-71. [PubMed:10421612 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.
Gene Name:
SLCO1B1
Uniprot ID:
Q9Y6L6
Molecular Weight:
76447.99 Da
References
  1. Tirona RG, Leake BF, Wolkoff AW, Kim RB: Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation. J Pharmacol Exp Ther. 2003 Jan;304(1):223-8. [PubMed:12490595 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Organic anion transmembrane transporter activity
Specific Function:
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
Gene Name:
ABCC2
Uniprot ID:
Q92887
Molecular Weight:
174205.64 Da
References
  1. Huisman MT, Smit JW, Crommentuyn KM, Zelcer N, Wiltshire HR, Beijnen JH, Schinkel AH: Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs. AIDS. 2002 Nov 22;16(17):2295-301. [PubMed:12441801 ]
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Drug created on June 13, 2005 07:24 / Updated on September 27, 2016 02:25