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Identification
NameArdeparin
Accession NumberDB00407  (APRD00803)
TypeSmall Molecule
GroupsApproved, Withdrawn
DescriptionArdeparin, marketed under the US trade name Normiflo, is a low molecular weight heparin (LMWH) anticoagulant used for the prevention of postoperative venous thrombosis. Ardeparin is derived via peroxide degradation of heparin extracted from porcine intestinal mucosa. Its molecular weight ranges from 2000 to 15,000 with an average molecular weight of 5500 to 6500. Normiflo was withdrawn from the US market in March 2000.
Structure
Thumb
Synonyms
Ardeparin sodium
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
NormifloWyeth-Ayerst (United States)
Brand mixturesNot Available
SaltsNot Available
Categories
UNIIV5T10N50RD
CAS number9041-08-1
WeightNot Available
Chemical FormulaNot Available
InChI KeyNot Available
InChINot Available
IUPAC NameNot Available
SMILESNot Available
Taxonomy
ClassificationNot classified
Pharmacology
IndicationFor prevention of deep vein thrombosis, which may result in pulmonary embolism, following knee surgery.
PharmacodynamicsArdeparin, an anticoagulant, is a fractionated heparin. It acts at multiple sites in the normal coagulation system to inhibit reactions that lead to the clotting of blood and the formation of fibrin clots both in vitro and in vivo.
Mechanism of actionArdeparin binds to antithrombin III, accelerating its activity in inactivating factor Xa and thrombin, thereby inhibiting thrombosis. Ardeparin also binds to heparin cofactor II, inhibiting thrombin. Ardeparin does not effect prothrombin time (PT) assays and may prolong activated partial thromboplastin time (APTT). Ardeparin has double the anti-factor Xa activity versus anti-factor IIa activity, compared to unfractionated heparin which has approximately equal anti-factor Xa activity and anti-factor IIa activity.
Related Articles
AbsorptionWell absorbed following subcutaneous administration, with a mean bioavailability of 92% (based on anti-factor Xa activity).
Volume of distributionNot Available
Protein bindingNot Available
Metabolism

Liver and the reticulo-endothelial system are the sites of biotransformation.

Route of eliminationNot Available
Half lifeElimination half-life for anti-factor Xa activity averages 3.3 hours following a single intravenous dose, while elimination half-life for anti-factor IIa activity averages 1.2 hours following a single intravenous dose.
ClearanceNot Available
ToxicitySymptoms of overdose may include excessive bleeding and bruising.
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Enoxaparin Action PathwayDrug actionSMP00272
Ardeparin Action PathwayDrug actionSMP00275
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal AbsorptionNot AvailableNot Available
Blood Brain BarrierNot AvailableNot Available
Caco-2 permeableNot AvailableNot Available
P-glycoprotein substrateNot AvailableNot Available
P-glycoprotein inhibitor INot AvailableNot Available
P-glycoprotein inhibitor IINot AvailableNot Available
Renal organic cation transporterNot AvailableNot Available
CYP450 2C9 substrateNot AvailableNot Available
CYP450 2D6 substrateNot AvailableNot Available
CYP450 3A4 substrateNot AvailableNot Available
CYP450 1A2 substrateNot AvailableNot Available
CYP450 2C9 inhibitorNot AvailableNot Available
CYP450 2D6 inhibitorNot AvailableNot Available
CYP450 2C19 inhibitorNot AvailableNot Available
CYP450 3A4 inhibitorNot AvailableNot Available
CYP450 inhibitory promiscuityNot AvailableNot Available
Ames testNot AvailableNot Available
CarcinogenicityNot AvailableNot Available
BiodegradationNot AvailableNot Available
Rat acute toxicityNot AvailableNot applicable
hERG inhibition (predictor I)Not AvailableNot Available
hERG inhibition (predictor II)Not AvailableNot Available
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Wyeth ayerst laboratories
PackagersNot Available
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
water solubilitySolubleNot Available
Predicted PropertiesNot Available
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesNot Available
AHFS Codes
  • 20:12.04.16
  • 92:00.00
PDB Entries
FDA labelNot Available
MSDSDownload (65.5 KB)
Interactions
Drug Interactions
Drug
AbciximabAbciximab may increase the anticoagulant activities of Ardeparin.
AceclofenacAceclofenac may increase the anticoagulant activities of Ardeparin.
AcenocoumarolArdeparin may increase the anticoagulant activities of Acenocoumarol.
Acetylsalicylic acidAcetylsalicylic acid may increase the anticoagulant activities of Ardeparin.
AdapaleneAdapalene may increase the anticoagulant activities of Ardeparin.
AliskirenArdeparin may increase the hyperkalemic activities of Aliskiren.
AllylestrenolThe therapeutic efficacy of Ardeparin can be decreased when used in combination with Allylestrenol.
AlprostadilAlprostadil may increase the anticoagulant activities of Ardeparin.
AlteplaseAlteplase may increase the anticoagulant activities of Ardeparin.
AltrenogestThe therapeutic efficacy of Ardeparin can be decreased when used in combination with Altrenogest.
ALX-0081ALX-0081 may increase the anticoagulant activities of Ardeparin.
AmilorideArdeparin may increase the hyperkalemic activities of Amiloride.
Aminosalicylic AcidAminosalicylic Acid may increase the anticoagulant activities of Ardeparin.
AnagrelideAnagrelide may increase the anticoagulant activities of Ardeparin.
AncrodArdeparin may increase the anticoagulant activities of Ancrod.
AnistreplaseAnistreplase may increase the anticoagulant activities of Ardeparin.
AntipyrineAntipyrine may increase the anticoagulant activities of Ardeparin.
Antithrombin III humanArdeparin may increase the anticoagulant activities of Antithrombin III human.
ApixabanApixaban may increase the anticoagulant activities of Ardeparin.
ApremilastApremilast may increase the anticoagulant activities of Ardeparin.
AprotininThe therapeutic efficacy of Ardeparin can be decreased when used in combination with Aprotinin.
ArgatrobanArgatroban may increase the anticoagulant activities of Ardeparin.
AstaxanthinAstaxanthin may increase the anticoagulant activities of Ardeparin.
AzapropazoneAzapropazone may increase the anticoagulant activities of Ardeparin.
AzelastineAzelastine may increase the anticoagulant activities of Ardeparin.
Azilsartan medoxomilArdeparin may increase the hyperkalemic activities of Azilsartan medoxomil.
BalsalazideBalsalazide may increase the anticoagulant activities of Ardeparin.
BatroxobinBatroxobin may increase the anticoagulant activities of Ardeparin.
BazedoxifeneBazedoxifene may decrease the anticoagulant activities of Ardeparin.
BecaplerminBecaplermin may increase the anticoagulant activities of Ardeparin.
BemiparinBemiparin may increase the anticoagulant activities of Ardeparin.
BenazeprilArdeparin may increase the hyperkalemic activities of Benazepril.
BenoxaprofenBenoxaprofen may increase the anticoagulant activities of Ardeparin.
BeraprostBeraprost may increase the anticoagulant activities of Ardeparin.
BivalirudinBivalirudin may increase the anticoagulant activities of Ardeparin.
BromfenacBromfenac may increase the anticoagulant activities of Ardeparin.
CanagliflozinArdeparin may increase the hyperkalemic activities of Canagliflozin.
CandesartanArdeparin may increase the hyperkalemic activities of Candesartan.
CandoxatrilArdeparin may increase the hyperkalemic activities of Candoxatril.
CangrelorCangrelor may increase the anticoagulant activities of Ardeparin.
CaptoprilArdeparin may increase the hyperkalemic activities of Captopril.
CarprofenCarprofen may increase the anticoagulant activities of Ardeparin.
CastanospermineCastanospermine may increase the anticoagulant activities of Ardeparin.
CelecoxibCelecoxib may increase the anticoagulant activities of Ardeparin.
CertoparinArdeparin may increase the anticoagulant activities of Certoparin.
ChloroquineChloroquine may increase the anticoagulant activities of Ardeparin.
ChlorotrianiseneChlorotrianisene may decrease the anticoagulant activities of Ardeparin.
CilazaprilArdeparin may increase the hyperkalemic activities of Cilazapril.
CilostazolCilostazol may increase the anticoagulant activities of Ardeparin.
Citric AcidArdeparin may increase the anticoagulant activities of Citric Acid.
ClonixinClonixin may increase the anticoagulant activities of Ardeparin.
ClopidogrelClopidogrel may increase the anticoagulant activities of Ardeparin.
CollagenaseThe risk or severity of adverse effects can be increased when Ardeparin is combined with Collagenase.
Conjugated Equine EstrogensConjugated Equine Estrogens may decrease the anticoagulant activities of Ardeparin.
D-LimoneneD-Limonene may increase the anticoagulant activities of Ardeparin.
Dabigatran etexilateDabigatran etexilate may increase the anticoagulant activities of Ardeparin.
DalteparinArdeparin may increase the anticoagulant activities of Dalteparin.
DanaparoidArdeparin may increase the anticoagulant activities of Danaparoid.
DasatinibDasatinib may increase the anticoagulant activities of Ardeparin.
DeferasiroxThe risk or severity of adverse effects can be increased when Ardeparin is combined with Deferasirox.
DefibrotideDefibrotide may increase the anticoagulant activities of Ardeparin.
Deoxycholic AcidThe risk or severity of adverse effects can be increased when Ardeparin is combined with Deoxycholic Acid.
DesirudinArdeparin may increase the anticoagulant activities of Desirudin.
DesmoteplaseDesmoteplase may increase the anticoagulant activities of Ardeparin.
DesogestrelThe therapeutic efficacy of Ardeparin can be decreased when used in combination with Desogestrel.
DextranArdeparin may increase the anticoagulant activities of Dextran.
Dextran 40Ardeparin may increase the anticoagulant activities of Dextran 40.
Dextran 70Ardeparin may increase the anticoagulant activities of Dextran 70.
Dextran 75Ardeparin may increase the anticoagulant activities of Dextran 75.
DiclofenacDiclofenac may increase the anticoagulant activities of Ardeparin.
DicoumarolDicoumarol may increase the anticoagulant activities of Ardeparin.
DienestrolDienestrol may decrease the anticoagulant activities of Ardeparin.
DienogestThe therapeutic efficacy of Ardeparin can be decreased when used in combination with Dienogest.
DiethylstilbestrolDiethylstilbestrol may decrease the anticoagulant activities of Ardeparin.
DiflunisalDiflunisal may increase the anticoagulant activities of Ardeparin.
DipyridamoleDipyridamole may increase the anticoagulant activities of Ardeparin.
DitazoleDitazole may increase the anticoagulant activities of Ardeparin.
DrospirenoneThe therapeutic efficacy of Ardeparin can be decreased when used in combination with Drospirenone.
Drotrecogin alfaDrotrecogin alfa may increase the anticoagulant activities of Ardeparin.
DroxicamDroxicam may increase the anticoagulant activities of Ardeparin.
DydrogesteroneThe therapeutic efficacy of Ardeparin can be decreased when used in combination with Dydrogesterone.
Edetic AcidArdeparin may increase the anticoagulant activities of Edetic Acid.
EdoxabanEdoxaban may increase the anticoagulant activities of Ardeparin.
EnalaprilArdeparin may increase the hyperkalemic activities of Enalapril.
EnalaprilatArdeparin may increase the hyperkalemic activities of Enalaprilat.
EnoxaparinArdeparin may increase the anticoagulant activities of Enoxaparin.
EpinastineEpinastine may increase the anticoagulant activities of Ardeparin.
EpirizoleEpirizole may increase the anticoagulant activities of Ardeparin.
EplerenoneArdeparin may increase the hyperkalemic activities of Eplerenone.
EpoprostenolEpoprostenol may increase the anticoagulant activities of Ardeparin.
EpoprostenolThe risk or severity of adverse effects can be increased when Ardeparin is combined with Epoprostenol.
EprosartanArdeparin may increase the hyperkalemic activities of Eprosartan.
EptifibatideEptifibatide may increase the anticoagulant activities of Ardeparin.
EstradiolEstradiol may decrease the anticoagulant activities of Ardeparin.
EstriolEstriol may decrease the anticoagulant activities of Ardeparin.
EstroneEstrone may decrease the anticoagulant activities of Ardeparin.
EtanerceptEtanercept may increase the anticoagulant activities of Ardeparin.
Ethinyl EstradiolEthinyl Estradiol may decrease the anticoagulant activities of Ardeparin.
Ethyl biscoumacetateArdeparin may increase the anticoagulant activities of Ethyl biscoumacetate.
EtodolacEtodolac may increase the anticoagulant activities of Ardeparin.
EtofenamateEtofenamate may increase the anticoagulant activities of Ardeparin.
EtonogestrelThe therapeutic efficacy of Ardeparin can be decreased when used in combination with Etonogestrel.
EtoricoxibEtoricoxib may increase the anticoagulant activities of Ardeparin.
Evening primrose oilEvening primrose oil may increase the anticoagulant activities of Ardeparin.
exisulindexisulind may increase the anticoagulant activities of Ardeparin.
FenbufenFenbufen may increase the anticoagulant activities of Ardeparin.
FenoprofenFenoprofen may increase the anticoagulant activities of Ardeparin.
FibrinolysinFibrinolysin may increase the anticoagulant activities of Ardeparin.
FloctafenineFloctafenine may increase the anticoagulant activities of Ardeparin.
FlunixinFlunixin may increase the anticoagulant activities of Ardeparin.
FlurbiprofenFlurbiprofen may increase the anticoagulant activities of Ardeparin.
Fondaparinux sodiumArdeparin may increase the anticoagulant activities of Fondaparinux sodium.
ForasartanArdeparin may increase the hyperkalemic activities of Forasartan.
FosinoprilArdeparin may increase the hyperkalemic activities of Fosinopril.
GenisteinGenistein may decrease the anticoagulant activities of Ardeparin.
GestodeneThe therapeutic efficacy of Ardeparin can be decreased when used in combination with Gestodene.
HeminHemin may increase the anticoagulant activities of Ardeparin.
HeparinArdeparin may increase the anticoagulant activities of Heparin.
HexestrolHexestrol may decrease the anticoagulant activities of Ardeparin.
HirulogArdeparin may increase the anticoagulant activities of Hirulog.
HMPL-004HMPL-004 may increase the anticoagulant activities of Ardeparin.
Hydroxyprogesterone caproateThe therapeutic efficacy of Ardeparin can be decreased when used in combination with Hydroxyprogesterone caproate.
Ibritumomab tiuxetanThe risk or severity of adverse effects can be increased when Ardeparin is combined with Ibritumomab tiuxetan.
IbrutinibThe risk or severity of adverse effects can be increased when Ibrutinib is combined with Ardeparin.
IbudilastIbudilast may increase the anticoagulant activities of Ardeparin.
IbuprofenIbuprofen may increase the anticoagulant activities of Ardeparin.
IbuproxamIbuproxam may increase the anticoagulant activities of Ardeparin.
IcatibantIcatibant may increase the anticoagulant activities of Ardeparin.
Icosapent ethylIcosapent ethyl may increase the anticoagulant activities of Ardeparin.
IfenprodilIfenprodil may increase the anticoagulant activities of Ardeparin.
IloprostIloprost may increase the anticoagulant activities of Ardeparin.
IloprostThe risk or severity of adverse effects can be increased when Ardeparin is combined with Iloprost.
IndomethacinIndomethacin may increase the anticoagulant activities of Ardeparin.
IndoprofenIndoprofen may increase the anticoagulant activities of Ardeparin.
IrbesartanArdeparin may increase the hyperkalemic activities of Irbesartan.
IsoxicamIsoxicam may increase the anticoagulant activities of Ardeparin.
KebuzoneKebuzone may increase the anticoagulant activities of Ardeparin.
KetoprofenKetoprofen may increase the anticoagulant activities of Ardeparin.
KetorolacKetorolac may increase the anticoagulant activities of Ardeparin.
LeflunomideLeflunomide may increase the anticoagulant activities of Ardeparin.
LepirudinLepirudin may increase the anticoagulant activities of Ardeparin.
LevonorgestrelThe therapeutic efficacy of Ardeparin can be decreased when used in combination with Levonorgestrel.
LimaprostThe risk or severity of adverse effects can be increased when Limaprost is combined with Ardeparin.
LisinoprilArdeparin may increase the hyperkalemic activities of Lisinopril.
LornoxicamLornoxicam may increase the anticoagulant activities of Ardeparin.
LosartanArdeparin may increase the hyperkalemic activities of Losartan.
LoxoprofenLoxoprofen may increase the anticoagulant activities of Ardeparin.
LumiracoxibLumiracoxib may increase the anticoagulant activities of Ardeparin.
Magnesium salicylateMagnesium salicylate may increase the anticoagulant activities of Ardeparin.
MasoprocolMasoprocol may increase the anticoagulant activities of Ardeparin.
Meclofenamic acidMeclofenamic acid may increase the anticoagulant activities of Ardeparin.
MedrogestoneThe therapeutic efficacy of Ardeparin can be decreased when used in combination with Medrogestone.
Medroxyprogesterone acetateThe therapeutic efficacy of Ardeparin can be decreased when used in combination with Medroxyprogesterone acetate.
Mefenamic acidMefenamic acid may increase the anticoagulant activities of Ardeparin.
Megestrol acetateThe therapeutic efficacy of Ardeparin can be decreased when used in combination with Megestrol acetate.
MeloxicamMeloxicam may increase the anticoagulant activities of Ardeparin.
MesalazineMesalazine may increase the anticoagulant activities of Ardeparin.
MestranolMestranol may decrease the anticoagulant activities of Ardeparin.
MetamizoleMetamizole may increase the anticoagulant activities of Ardeparin.
MilrinoneMilrinone may increase the anticoagulant activities of Ardeparin.
MoexiprilArdeparin may increase the hyperkalemic activities of Moexipril.
Mycophenolate mofetilMycophenolate mofetil may increase the anticoagulant activities of Ardeparin.
Mycophenolic acidMycophenolic acid may increase the anticoagulant activities of Ardeparin.
NabumetoneNabumetone may increase the anticoagulant activities of Ardeparin.
NadroparinArdeparin may increase the anticoagulant activities of Nadroparin.
NaftifineNaftifine may increase the anticoagulant activities of Ardeparin.
NaproxenNaproxen may increase the anticoagulant activities of Ardeparin.
NCX 4016NCX 4016 may increase the anticoagulant activities of Ardeparin.
NepafenacNepafenac may increase the anticoagulant activities of Ardeparin.
Niflumic AcidNiflumic Acid may increase the anticoagulant activities of Ardeparin.
NimesulideNimesulide may increase the anticoagulant activities of Ardeparin.
NintedanibThe risk or severity of adverse effects can be increased when Ardeparin is combined with Nintedanib.
NorethisteroneThe therapeutic efficacy of Ardeparin can be decreased when used in combination with Norethisterone.
ObinutuzumabThe risk or severity of adverse effects can be increased when Ardeparin is combined with Obinutuzumab.
OlmesartanArdeparin may increase the hyperkalemic activities of Olmesartan.
OlopatadineOlopatadine may increase the anticoagulant activities of Ardeparin.
OlsalazineOlsalazine may increase the anticoagulant activities of Ardeparin.
Omacetaxine mepesuccinateThe risk or severity of adverse effects can be increased when Ardeparin is combined with Omacetaxine mepesuccinate.
OmapatrilatArdeparin may increase the hyperkalemic activities of Omapatrilat.
Omega-3 fatty acidsOmega-3 fatty acids may increase the anticoagulant activities of Ardeparin.
OrgoteinOrgotein may increase the anticoagulant activities of Ardeparin.
OtamixabanArdeparin may increase the anticoagulant activities of Otamixaban.
OxaprozinOxaprozin may increase the anticoagulant activities of Ardeparin.
OxyphenbutazoneOxyphenbutazone may increase the anticoagulant activities of Ardeparin.
PaliferminThe serum concentration of Palifermin can be increased when it is combined with Ardeparin.
ParecoxibParecoxib may increase the anticoagulant activities of Ardeparin.
ParnaparinParnaparin may increase the anticoagulant activities of Ardeparin.
Pentosan PolysulfatePentosan Polysulfate may increase the anticoagulant activities of Ardeparin.
PentoxifyllinePentoxifylline may increase the anticoagulant activities of Ardeparin.
PerindoprilArdeparin may increase the hyperkalemic activities of Perindopril.
PhenindioneArdeparin may increase the anticoagulant activities of Phenindione.
PhenprocoumonArdeparin may increase the anticoagulant activities of Phenprocoumon.
PhenylbutazonePhenylbutazone may increase the anticoagulant activities of Ardeparin.
PimecrolimusPimecrolimus may increase the anticoagulant activities of Ardeparin.
PirfenidonePirfenidone may increase the anticoagulant activities of Ardeparin.
PiroxicamPiroxicam may increase the anticoagulant activities of Ardeparin.
PlasminPlasmin may increase the anticoagulant activities of Ardeparin.
Polyestradiol phosphatePolyestradiol phosphate may decrease the anticoagulant activities of Ardeparin.
PrasugrelPrasugrel may increase the anticoagulant activities of Ardeparin.
ProgesteroneThe therapeutic efficacy of Ardeparin can be decreased when used in combination with Progesterone.
PropacetamolPropacetamol may increase the anticoagulant activities of Ardeparin.
Protein CArdeparin may increase the anticoagulant activities of Protein C.
ProtocatechualdehydeArdeparin may increase the anticoagulant activities of Protocatechualdehyde.
PTC299PTC299 may increase the anticoagulant activities of Ardeparin.
QuinaprilArdeparin may increase the hyperkalemic activities of Quinapril.
QuinestrolQuinestrol may decrease the anticoagulant activities of Ardeparin.
RamiprilArdeparin may increase the hyperkalemic activities of Ramipril.
RescinnamineArdeparin may increase the hyperkalemic activities of Rescinnamine.
ResveratrolResveratrol may increase the anticoagulant activities of Ardeparin.
ReteplaseReteplase may increase the anticoagulant activities of Ardeparin.
ReviparinArdeparin may increase the anticoagulant activities of Reviparin.
RidogrelRidogrel may increase the anticoagulant activities of Ardeparin.
RivaroxabanArdeparin may increase the anticoagulant activities of Rivaroxaban.
RofecoxibRofecoxib may increase the anticoagulant activities of Ardeparin.
RosiglitazoneRosiglitazone may increase the anticoagulant activities of Ardeparin.
SalicylamideSalicylamide may increase the anticoagulant activities of Ardeparin.
Salicylic acidSalicylic acid may increase the anticoagulant activities of Ardeparin.
SalsalateSalsalate may increase the anticoagulant activities of Ardeparin.
SaprisartanArdeparin may increase the hyperkalemic activities of Saprisartan.
SaralasinArdeparin may increase the hyperkalemic activities of Saralasin.
SCH-530348SCH-530348 may increase the anticoagulant activities of Ardeparin.
SelexipagSelexipag may increase the anticoagulant activities of Ardeparin.
SeratrodastSeratrodast may increase the anticoagulant activities of Ardeparin.
SevofluraneSevoflurane may increase the anticoagulant activities of Ardeparin.
SpiraprilArdeparin may increase the hyperkalemic activities of Spirapril.
SpironolactoneArdeparin may increase the hyperkalemic activities of Spironolactone.
SRT501SRT501 may increase the anticoagulant activities of Ardeparin.
StreptokinaseStreptokinase may increase the anticoagulant activities of Ardeparin.
SugammadexSugammadex may increase the anticoagulant activities of Ardeparin.
SulfasalazineSulfasalazine may increase the anticoagulant activities of Ardeparin.
SulindacSulindac may increase the anticoagulant activities of Ardeparin.
SulodexideArdeparin may increase the anticoagulant activities of Sulodexide.
SuprofenSuprofen may increase the anticoagulant activities of Ardeparin.
Synthetic Conjugated Estrogens, ASynthetic Conjugated Estrogens, A may decrease the anticoagulant activities of Ardeparin.
Synthetic Conjugated Estrogens, BSynthetic Conjugated Estrogens, B may decrease the anticoagulant activities of Ardeparin.
TasosartanArdeparin may increase the hyperkalemic activities of Tasosartan.
TelmisartanArdeparin may increase the hyperkalemic activities of Telmisartan.
TemocaprilArdeparin may increase the hyperkalemic activities of Temocapril.
TenecteplaseTenecteplase may increase the anticoagulant activities of Ardeparin.
TenoxicamTenoxicam may increase the anticoagulant activities of Ardeparin.
TepoxalinTepoxalin may increase the anticoagulant activities of Ardeparin.
TeriflunomideTeriflunomide may increase the anticoagulant activities of Ardeparin.
TesmilifeneTesmilifene may increase the anticoagulant activities of Ardeparin.
Tiaprofenic acidTiaprofenic acid may increase the anticoagulant activities of Ardeparin.
TiboloneTibolone may increase the anticoagulant activities of Ardeparin.
TicagrelorTicagrelor may increase the anticoagulant activities of Ardeparin.
TiclopidineTiclopidine may increase the anticoagulant activities of Ardeparin.
TinzaparinTinzaparin may increase the anticoagulant activities of Ardeparin.
TipranavirTipranavir may increase the anticoagulant activities of Ardeparin.
TirofibanTirofiban may increase the anticoagulant activities of Ardeparin.
Tolfenamic AcidTolfenamic Acid may increase the anticoagulant activities of Ardeparin.
TolmetinTolmetin may increase the anticoagulant activities of Ardeparin.
TositumomabThe risk or severity of adverse effects can be increased when Ardeparin is combined with Tositumomab.
TrandolaprilArdeparin may increase the hyperkalemic activities of Trandolapril.
TranilastTranilast may increase the anticoagulant activities of Ardeparin.
TrapidilTrapidil may increase the anticoagulant activities of Ardeparin.
TreprostinilTreprostinil may increase the anticoagulant activities of Ardeparin.
TreprostinilThe risk or severity of adverse effects can be increased when Ardeparin is combined with Treprostinil.
TriamtereneArdeparin may increase the hyperkalemic activities of Triamterene.
TriflusalTriflusal may increase the anticoagulant activities of Ardeparin.
Trisalicylate-cholineTrisalicylate-choline may increase the anticoagulant activities of Ardeparin.
UrokinaseUrokinase may increase the anticoagulant activities of Ardeparin.
ValdecoxibValdecoxib may increase the anticoagulant activities of Ardeparin.
ValsartanArdeparin may increase the hyperkalemic activities of Valsartan.
Vitamin EVitamin E may increase the anticoagulant activities of Ardeparin.
VorapaxarThe risk or severity of adverse effects can be increased when Vorapaxar is combined with Ardeparin.
WarfarinArdeparin may increase the anticoagulant activities of Warfarin.
XimelagatranArdeparin may increase the anticoagulant activities of Ximelagatran.
ZaltoprofenZaltoprofen may increase the anticoagulant activities of Ardeparin.
ZeranolZeranol may decrease the anticoagulant activities of Ardeparin.
ZileutonZileuton may increase the anticoagulant activities of Ardeparin.
ZomepiracZomepirac may increase the anticoagulant activities of Ardeparin.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
potentiator
General Function:
Serine-type endopeptidase inhibitor activity
Specific Function:
Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.
Gene Name:
SERPINC1
Uniprot ID:
P01008
Molecular Weight:
52601.935 Da
References
  1. Mousa SA: The low molecular weight heparin, tinzaparin, in thrombosis and beyond. Cardiovasc Drug Rev. 2002 Fall;20(3):199-216. [PubMed:12397367 ]
  2. Lin P, Sinha U, Betz A: Antithrombin binding of low molecular weight heparins and inhibition of factor Xa. Biochim Biophys Acta. 2001 Apr 3;1526(1):105-13. [PubMed:11287128 ]
  3. Shaughnessy SG, Young E, Deschamps P, Hirsh J: The effects of low molecular weight and standard heparin on calcium loss from fetal rat calvaria. Blood. 1995 Aug 15;86(4):1368-73. [PubMed:7632944 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Serine-type endopeptidase inhibitor activity
Specific Function:
Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.
Gene Name:
SERPIND1
Uniprot ID:
P05546
Molecular Weight:
57070.16 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Mousa SA: The low molecular weight heparin, tinzaparin, in thrombosis and beyond. Cardiovasc Drug Rev. 2002 Fall;20(3):199-216. [PubMed:12397367 ]
  4. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Comments
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23