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Identification
NameHydroxyzine
Accession NumberDB00557  (APRD00688)
TypeSmall Molecule
GroupsApproved
Description

A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite cetirizine, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative. [PubChem]

Structure
Thumb
Synonyms
Hidroxizina
Hychotine
Hydroksyzyny
Hydroxine
Hydroxizine
Hydroxizinum
Hydroxycine
Hydroxyzin
Hydroxyzine
Hydroxyzinum
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Atarax Cap 10mgcapsule10 mgoralErfa Canada 2012 Inc1956-12-312005-09-15Canada
Atarax Cap 25mgcapsule25 mgoralErfa Canada 2012 Inc1956-12-312005-09-15Canada
Atarax Cap 50mgcapsule50 mgoralErfa Canada 2012 Inc1959-12-312005-09-15Canada
Atarax Im Sol 50mg/mlsolution50 mgintramuscularErfa Canada 2012 Inc1957-12-312005-08-18Canada
Atarax Syrup 2mg/mlsyrup2 mgoralErfa Canada 2012 Inc1956-12-31Not applicableCanada
Hydroxyzine Hydrochloride Injectionliquid50 mgintramuscularFresenius Kabi Canada Ltd2001-04-05Not applicableCanada
Hydroxyzine Hydrochloride Injection USPliquid50 mgintramuscularSandoz Canada Incorporated1987-12-31Not applicableCanada
Hydroxyzine Hydrochloride Injection, USPsolution50 mgintramuscularSterimax Inc1997-05-16Not applicableCanada
Hydroxyzine-10capsule10 mgoralPro Doc Limitee1987-12-312014-07-24Canada
Hydroxyzine-25capsule25 mgoralPro Doc Limitee1987-12-312014-07-24Canada
Hydroxyzine-50capsule50 mgoralPro Doc Limitee1987-12-312014-07-24Canada
Multipax Cap 10mgcapsule10 mgoralRhone Poulenc Rorer Canada Inc.1992-12-311997-08-13Canada
Multipax Cap 25mgcapsule25 mgoralRhone Poulenc Rorer Canada Inc.1992-12-312000-07-28Canada
Novo-hydroxyzincapsule50 mgoralTeva Canada Limited1987-12-31Not applicableCanada
Novo-hydroxyzincapsule25 mgoralTeva Canada Limited1987-12-31Not applicableCanada
Novo-hydroxyzincapsule10 mgoralTeva Canada Limited1987-12-31Not applicableCanada
Nu-hydroxyzinecapsule25 mgoralNu Pharm Inc1995-12-312012-09-04Canada
Nu-hydroxyzinecapsule10 mgoralNu Pharm Inc1995-12-312012-09-04Canada
Nu-hydroxyzinecapsule50 mgoralNu Pharm Inc1995-12-312012-09-04Canada
PMS Hydroxyzine Cap 10mgcapsule10 mgoralPharmascience Inc1988-12-31Not applicableCanada
PMS Hydroxyzine Cap 25mgcapsule25 mgoralPharmascience Inc1988-12-31Not applicableCanada
PMS Hydroxyzine Cap 50mgcapsule50 mgoralPharmascience Inc1988-12-31Not applicableCanada
PMS Hydroxyzine Syr 10mg/5mlsyrup10 mgoralPharmascience Inc1988-12-31Not applicableCanada
Riva-hydroxyzin 10mg Capsulescapsule10 mgoralLaboratoire Riva Inc1999-11-232013-07-31Canada
Riva-hydroxyzin 25mg Capsulescapsule25 mgoralLaboratoire Riva Inc1999-11-232013-07-31Canada
Riva-hydroxyzin 50mg Capsulescapsule50 mgoralLaboratoire Riva Inc1999-11-232013-07-31Canada
Vistarilsolution50 mg/mLintramuscularRoerig1957-09-18Not applicableUs
Vistarilcapsule50 mg/1oralREMEDYREPACK INC.2013-03-11Not applicableUs
Vistarilcapsule50 mg/1oralPfizer Laboratories Div Pfizer Inc1968-11-15Not applicableUs
Vistarilcapsule25 mg/1oralPfizer Laboratories Div Pfizer Inc1994-11-28Not applicableUs
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo Hydroxyzine Cap 10mgcapsule10 mgoralApotex Inc1986-12-31Not applicableCanada
Apo Hydroxyzine Cap 25mgcapsule25 mgoralApotex Inc1986-12-31Not applicableCanada
Apo Hydroxyzine Cap 50mgcapsule50 mgoralApotex Inc1986-12-31Not applicableCanada
Hydoxyzine Pamoatecapsule25 mg/1oralPd Rx Pharmaceuticals, Inc.1981-12-14Not applicableUs
Hydroxyzinetablet, film coated50 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2007-03-20Not applicableUs
Hydroxyzineinjection, solution50 mg/mLintramuscularGeneral Injectables & Vaccines, Inc2010-03-01Not applicableUs
Hydroxyzinetablet, film coated25 mg/1oralBlenheim Pharmacal, Inc.2010-05-17Not applicableUs
Hydroxyzinetablet, film coated10 mg/1oralBlenheim Pharmacal, Inc.2009-12-28Not applicableUs
Hydroxyzinetablet, film coated25 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2007-03-20Not applicableUs
Hydroxyzinetablet, film coated10 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2007-03-20Not applicableUs
Hydroxyzineinjection, solution50 mg/mLintramuscularGeneral Injectables & Vaccines, Inc2010-03-01Not applicableUs
Hydroxyzinetablet, film coated50 mg/1oralMajor Pharmaceuticals2007-03-20Not applicableUs
Hydroxyzinesolution10 mg/5mLoralPreferred Pharmaceuticals, Inc.2015-08-21Not applicableUs
Hydroxyzineinjection, solution50 mg/mLintramuscularGeneral Injectables & Vaccines, Inc2010-03-01Not applicableUs
Hydroxyzinetablet, film coated25 mg/1oralMajor Pharmaceuticals2007-03-20Not applicableUs
Hydroxyzineinjection, solution25 mg/mLintramuscularGeneral Injectables & Vaccines, Inc2010-03-01Not applicableUs
Hydroxyzinetablet, film coated10 mg/1oralMajor Pharmaceuticals2007-03-20Not applicableUs
Hydroxyzine HCltablet, film coated10 mg/1oralDIRECT RX2016-02-12Not applicableUs
Hydroxyzine HClsolution10 mg/5mLoralSTI Pharma LLC1982-01-01Not applicableUs
Hydroxyzine Hydrochloridesolution10 mg/5mLoralQualitest Pharmaceuticals2002-04-10Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralMylan Institutional Inc.2010-08-13Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated50 mg/1oralA S Medication Solutions Llc2005-05-27Not applicableUs
Hydroxyzine Hydrochloridetablet50 mg/1oralCaraco Pharmaceutical Laboratories, Ltd.2009-03-31Not applicableUs
Hydroxyzine Hydrochloridetablet50 mg/1oralNorthstar Rx LLC2009-11-11Not applicableUs
Hydroxyzine Hydrochlorideinjection, solution25 mg/mLintramuscularCardinal Health1990-09-30Not applicableUs
Hydroxyzine Hydrochloridesyrup10 mg/5mLoralPhysicians Total Care, Inc.2000-09-13Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated50 mg/1oralLake Erie Medical DBA Quality Care Products LLC2012-07-24Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralClinical Solutions Wholesale2012-07-24Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated10 mg/1oralbryant ranch prepack2008-06-30Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated50 mg/1oralAmerican Health Packaging2009-01-13Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralRebel Distributors Corp2008-06-30Not applicableUs
Hydroxyzine Hydrochloridetablet25 mg/1oralHeritage Pharmaceuticals Inc.2012-03-24Not applicableUs
Hydroxyzine Hydrochloridetablet25 mg/1oralNorthstar Rx LLC2009-11-11Not applicableUs
Hydroxyzine Hydrochlorideinjection, solution50 mg/mLintramuscularAmerican Regent, Inc.1990-09-30Not applicableUs
Hydroxyzine Hydrochloridetablet50 mg/1oralHeritage Pharmaceuticals Inc.2012-03-24Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated10 mg/1oralTeva Pharmaceuticals USA Inc2013-02-19Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralPd Rx Pharmaceuticals, Inc.2012-07-24Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralPd Rx Pharmaceuticals, Inc.2007-06-29Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated10 mg/1oralMylan Institutional Inc.2010-08-13Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralLake Erie Medical DBA Quality Care Products LLC2012-07-24Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated50 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-11-28Not applicableUs
Hydroxyzine Hydrochlorideinjection, solution50 mg/mLintramuscularCardinal Health1990-09-30Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralDIRECT RX2015-01-01Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated50 mg/1oralGolden State Medical Supply, Inc.2008-09-24Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralAmerican Health Packaging2009-01-13Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralRed Pharm Drug Inc.2010-12-07Not applicableUs
Hydroxyzine Hydrochloridesolution10 mg/5mLoralPreferred Pharmaceuticals, Inc.2015-01-13Not applicableUs
Hydroxyzine Hydrochloridetablet10 mg/1oralHeritage Pharmaceuticals Inc.2012-03-24Not applicableUs
Hydroxyzine Hydrochloridetablet10 mg/1oralNorthstar Rx LLC2009-11-11Not applicableUs
Hydroxyzine Hydrochlorideinjection, solution50 mg/mLintramuscularAmerican Regent, Inc.1990-09-30Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated50 mg/1oralPd Rx Pharmaceuticals, Inc.2012-07-24Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated50 mg/1oralEpic Pharma, LLC2015-03-31Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-11-21Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralREMEDYREPACK INC.2014-03-03Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralWatson Laboratories, Inc.2011-11-212016-02-11Us
Hydroxyzine Hydrochloridesolution10 mg/5mLoralPhysicians Total Care, Inc.1994-08-01Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated10 mg/1oralA S Medication Solutions Llc2005-05-27Not applicableUs
Hydroxyzine Hydrochloridetablet25 mg/1oralCaraco Pharmaceutical Laboratories, Ltd.2009-03-31Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated50 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2008-06-30Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralProficient Rx LP2008-06-30Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated50 mg/1oralHeritage Pharmaceuticals Inc.2008-06-30Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated10 mg/1oralAmerican Health Packaging2009-01-13Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated10 mg/1oralPreferred Pharmaceuticals, Inc.2012-10-08Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated50 mg/1oralGlenmark Generics Inc., USA2008-03-01Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated50 mg/1oralKvk Tech, Inc.2012-07-24Not applicableUs
Hydroxyzine Hydrochlorideinjection, solution50 mg/mLintramuscularAmerican Regent, Inc.1990-09-30Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralPd Rx Pharmaceuticals, Inc.2012-07-24Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralEpic Pharma, LLC2015-03-31Not applicableUs
Hydroxyzine Hydrochloridetablet25 mg/1oralREMEDYREPACK INC.2011-03-30Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated50 mg/1oralAidarex Pharmaceuticals LLC2012-07-24Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated50 mg/1oralREMEDYREPACK INC.2014-01-30Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated10 mg/1oralWatson Laboratories, Inc.2011-11-212016-02-11Us
Hydroxyzine Hydrochloridetablet, film coated50 mg/1oralPhysicians Total Care, Inc.1993-09-21Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated50 mg/1oralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
Hydroxyzine Hydrochloridetablet10 mg/1oralCaraco Pharmaceutical Laboratories, Ltd.2009-03-31Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated10 mg/1oralBlenheim Pharmacal, Inc.2012-11-16Not applicableUs
Hydroxyzine Hydrochloridetablet50 mg/1oralREMEDYREPACK INC.2015-12-14Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralGolden State Medical Supply, Inc.2012-08-22Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralGlenmark Generics Inc., USA2008-03-01Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralKvk Tech, Inc.2012-07-24Not applicableUs
Hydroxyzine Hydrochlorideinjection, solution25 mg/mLintramuscularAmerican Regent, Inc.1990-09-30Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated10 mg/1oralKAISER FOUNDATION HOSPITALS2010-10-08Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated10 mg/1oralPd Rx Pharmaceuticals, Inc.2012-07-24Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated10 mg/1oralEpic Pharma, LLC2015-03-31Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralA S Medication Solutions Llc2005-05-27Not applicableUs
Hydroxyzine Hydrochloridetablet25 mg/1oralREMEDYREPACK INC.2011-05-16Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated50 mg/1oralREMEDYREPACK INC.2013-05-282016-04-05Us
Hydroxyzine Hydrochloridetablet, film coated50 mg/1oralWatson Laboratories, Inc.2011-11-212016-02-11Us
Hydroxyzine Hydrochloridetablet, film coated10 mg/1oralPhysicians Total Care, Inc.1994-07-28Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated10 mg/1oralPd Rx Pharmaceuticals, Inc.2007-06-29Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralCardinal Health2010-07-23Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated10 mg/1oralBlenheim Pharmacal, Inc.2011-04-18Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated10 mg/1oralGolden State Medical Supply, Inc.2008-09-24Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated50 mg/1oralProficient Rx LP2008-06-30Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralHeritage Pharmaceuticals Inc.2008-06-30Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralHarris Pharmaceutical, Inc.2007-06-29Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralLiberty Pharmaceuticals, Inc.2012-07-24Not applicableUs
Hydroxyzine Hydrochlorideinjection, solution50 mg/mLintramuscularFresenius Kabi USA, LLC2000-08-08Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralKAISER FOUNDATION HOSPITALS2010-10-08Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated50 mg/1oralPd Rx Pharmaceuticals, Inc.2007-06-29Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralA S Medication Solutions Llc2005-05-27Not applicableUs
Hydroxyzine Hydrochloridetablet25 mg/1oralREMEDYREPACK INC.2011-05-23Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralH.J. Harkins Company, Inc.2008-06-30Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated50 mg/1oralREMEDYREPACK INC.2013-06-04Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralPhysicians Total Care, Inc.1994-04-04Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated50 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Hydroxyzine Hydrochloridesolution10 mg/5mLoralKvk Tech, Inc.2008-09-26Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralBlenheim Pharmacal, Inc.2010-09-15Not applicableUs
Hydroxyzine Hydrochloridetablet25 mg/1oralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2011-03-01Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated50 mg/1oralCamber Pharmaceuticals, Inc.2008-05-29Not applicableUs
Hydroxyzine Hydrochloridesyrup10 mg/5mLoralProficient Rx LP1995-03-09Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated10 mg/1oralHeritage Pharmaceuticals Inc.2008-06-30Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated50 mg/1oralHarris Pharmaceutical, Inc.2007-06-29Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralDispensing Solutions, Inc.2005-05-27Not applicableUs
Hydroxyzine Hydrochloridesolution10 mg/5mLoralPreferred Pharmaceuticals, Inc.2014-02-06Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated10 mg/1oralGlenmark Generics Inc., USA2008-03-01Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated10 mg/1oralKvk Tech, Inc.2012-07-24Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated50 mg/1oralA S Medication Solutions Llc2005-05-27Not applicableUs
Hydroxyzine Hydrochloridetablet50 mg/1oralREMEDYREPACK INC.2011-03-11Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated50 mg/1oralQualitest Pharmaceuticals2005-05-27Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralNorthwind Pharmaceuticals, LLC2015-02-26Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated50 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Hydroxyzine Hydrochloridetablet10 mg/1oralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2011-03-01Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralCamber Pharmaceuticals, Inc.2008-05-29Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralProficient Rx LP2007-06-29Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated10 mg/1oralHarris Pharmaceutical, Inc.2007-06-29Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated50 mg/1oralGlenmark Pharmaceuticals Inc., Usa2015-02-01Not applicableUs
Hydroxyzine Hydrochloridesolution10 mg/5mLoralSilarx Pharmaceuticals, Inc.2013-08-21Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated50 mg/1oralMylan Pharmaceuticals Inc.2010-07-23Not applicableUs
Hydroxyzine Hydrochlorideinjection, solution25 mg/mLintramuscularFresenius Kabi USA, LLC2000-10-17Not applicableUs
Hydroxyzine Hydrochloridesyrup10 mg/5mLoralPharmaceutical Associates, Inc.2015-01-01Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated10 mg/1oralA S Medication Solutions Llc2012-07-24Not applicableUs
Hydroxyzine Hydrochloridecapsule50 mg/1oralREMEDYREPACK INC.2011-08-12Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralQualitest Pharmaceuticals2005-05-27Not applicableUs
Hydroxyzine Hydrochloridetablet10 mg/1oralNorthwind Pharmaceuticals, LLC2014-09-15Not applicableUs
Hydroxyzine Hydrochloridesyrup10 mg/5mLoralA S Medication Solutions Llc1995-03-09Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralPd Rx Pharmaceuticals, Inc.2010-12-07Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated50 mg/1oralBlenheim Pharmacal, Inc.2013-11-18Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralCardinal Health2009-01-13Not applicableUs
Hydroxyzine Hydrochloridesyrup10 mg/5mLoralMorton Grove Pharmaceuticals, Inc.1995-03-09Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated10 mg/1oralCamber Pharmaceuticals, Inc.2008-05-29Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralProficient Rx LP2005-05-27Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated10 mg/1oralRebel Distributors Corp2008-06-30Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralRed Pharm Drug Inc.2008-06-30Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralGlenmark Pharmaceuticals Inc., Usa2015-02-01Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralMc Kesson Contract Packaging2012-01-23Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralMylan Pharmaceuticals Inc.2010-07-23Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated50 mg/1oralTeva Pharmaceuticals USA Inc2012-10-22Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated10 mg/1oralQualitest Pharmaceuticals2005-05-27Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated50 mg/1oralMylan Institutional Inc.2010-08-13Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralA S Medication Solutions Llc2005-05-27Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated50 mg/1oralPd Rx Pharmaceuticals, Inc.2005-05-27Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralBlenheim Pharmacal, Inc.2013-11-18Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated50 mg/1oralClinical Solutions Wholesale2012-07-24Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated50 mg/1oralbryant ranch prepack2008-06-30Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated50 mg/1oralRebel Distributors Corp2008-06-30Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralRed Pharm Drug Inc.2009-08-07Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated10 mg/1oralPreferred Pharmaceuticals, Inc.2015-04-15Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated10 mg/1oralGlenmark Pharmaceuticals Inc., Usa2015-02-01Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralREMEDYREPACK INC.2016-02-11Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralLife Line Home Care Services, Inc.2012-01-18Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated10 mg/1oralMylan Pharmaceuticals Inc.2010-07-23Not applicableUs
Hydroxyzine Hydrochloridesolution10 mg/5mLoralHi Tech Pharmacal Co., Inc.1994-10-28Not applicableUs
Hydroxyzine Hydrochloridetablet, film coated25 mg/1oralTeva Pharmaceuticals USA Inc2012-10-09Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralAphena Pharma Solutions Tennessee, Llc1996-07-15Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralPhysicians Total Care, Inc.2000-02-09Not applicableUs
Hydroxyzine Pamoatecapsule50 mg/1oralBarr Laboratories Inc.1984-07-01Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralDIRECT RX2014-01-01Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2014-06-27Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralGolden State Medical Supply, Inc.2014-05-20Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralTYA Pharmaceuticals1984-07-01Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralREMEDYREPACK INC.2013-04-08Not applicableUs
Hydroxyzine Pamoatecapsule50 mg/1oralAmerican Health Packaging2013-06-12Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralRed Pharm Drug Inc.2010-07-01Not applicableUs
Hydroxyzine Pamoatecapsule50 mg/1oralAvera Mc Kennan Hospital2015-03-04Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralTYA Pharmaceuticals1996-07-15Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralPreferred Pharmaceuticals, Inc.2004-07-21Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralAmerican Health Packaging2015-02-15Not applicableUs
Hydroxyzine Pamoatecapsule50 mg/1oralAvera Mc Kennan Hospital2015-03-01Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralEon Labs, Inc.2014-06-27Not applicableUs
Hydroxyzine Pamoatecapsule50 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Hydroxyzine Pamoatecapsule50 mg/1oralTYA Pharmaceuticals1984-07-01Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralLake Erie Medical DBA Quality Care Products LLC1984-07-01Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralbryant ranch prepack1996-07-15Not applicableUs
Hydroxyzine Pamoatecapsule50 mg/1oralREMEDYREPACK INC.2013-03-19Not applicableUs
Hydroxyzine Pamoatecapsule50 mg/1oralPreferred Pharmaceuticals, Inc.2004-07-21Not applicableUs
Hydroxyzine Pamoatecapsule50 mg/1oralEon Labs, Inc.1981-12-14Not applicableUs
Hydroxyzine Pamoatecapsule50 mg/1oralMylan Institutional Inc.2007-11-26Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Hydroxyzine Pamoatecapsule50 mg/1oralSTAT Rx USA LLC1996-06-15Not applicableUs
Hydroxyzine Pamoatecapsule50 mg/1oralTYA Pharmaceuticals2010-11-17Not applicableUs
Hydroxyzine Pamoatecapsule50 mg/1oralContract Pharmacy Services Pa2010-08-16Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralEon Labs, Inc.1981-12-14Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralMylan Institutional Inc.2007-11-26Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralSTAT Rx USA LLC1981-12-14Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralCardinal Health2012-09-25Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralPreferred Pharmaceuticals, Inc.2013-04-22Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralH.J. Harkins Company, Inc.2010-07-01Not applicableUs
Hydroxyzine Pamoatecapsule50 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1981-12-14Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
Hydroxyzine Pamoatecapsule50 mg/1oralApotheca Inc.1981-12-14Not applicableUs
Hydroxyzine Pamoatecapsule50 mg/1oralREMEDYREPACK INC.2015-10-20Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralTYA Pharmaceuticals2010-11-17Not applicableUs
Hydroxyzine Pamoatecapsule50 mg/1oralAidarex Pharmaceuticals LLC1981-12-14Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralContract Pharmacy Services Pa2010-08-16Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralSTAT Rx USA LLC1996-07-15Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1981-12-14Not applicableUs
Hydroxyzine Pamoatecapsule50 mg/1oralWatson Laboratories, Inc.1996-06-15Not applicableUs
Hydroxyzine Pamoatecapsule50 mg/1oralPd Rx Pharmaceuticals, Inc.1981-12-14Not applicableUs
Hydroxyzine Pamoatecapsule50 mg/1oralCardinal Health2011-08-03Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralREMEDYREPACK INC.2015-03-09Not applicableUs
Hydroxyzine Pamoatecapsule50 mg/1oralClinical Solutions Wholsesale1981-12-14Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralPd Rx Pharmaceuticals, Inc.1981-12-14Not applicableUs
Hydroxyzine Pamoatecapsule50 mg/1oralWestwood Manufacturing2010-11-17Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralWatson Laboratories, Inc.1996-07-15Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralA S Medication Solutions Llc1981-12-142016-04-05Us
Hydroxyzine Pamoatecapsule25 mg/1oralPd Rx Pharmaceuticals, Inc.1996-07-15Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralBlenheim Pharmacal, Inc.2013-11-11Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralCardinal Health2013-06-12Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralREMEDYREPACK INC.2015-03-09Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralClinical Solutions Wholsesale1981-12-14Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralRebel Distributors Corp1996-07-15Not applicableUs
Hydroxyzine Pamoatecapsule50 mg/1oralRising Pharmaceuticals Inc.2010-11-17Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralAmerican Health Packaging2013-06-122015-11-30Us
Hydroxyzine Pamoatecapsule100 mg/1oralPd Rx Pharmaceuticals, Inc.2011-09-01Not applicableUs
Hydroxyzine Pamoatecapsule50 mg/1oralAv Kare, Inc.2013-03-07Not applicableUs
Hydroxyzine Pamoatecapsule100 mg/1oralBarr Laboratories Inc.1984-07-01Not applicableUs
Hydroxyzine Pamoatecapsule100 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralClinical Solutions Wholsesale1981-12-14Not applicableUs
Hydroxyzine Pamoatecapsule50 mg/1oralbryant ranch prepack1996-07-15Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralRising Pharmaceuticals Inc.2010-11-17Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralPreferred Pharmaceuticals, Inc.2014-07-23Not applicableUs
Hydroxyzine Pamoatecapsule50 mg/1oralA S Medication Solutions1981-12-14Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralAv Kare, Inc.2013-03-07Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC1996-07-15Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralREMEDYREPACK INC.2011-08-03Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralBarr Laboratories Inc.1984-07-01Not applicableUs
Hydroxyzine Pamoatecapsule50 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Hydroxyzine Pamoatecapsule50 mg/1oralGolden State Medical Supply, Inc.2014-05-20Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralREMEDYREPACK INC.2013-06-24Not applicableUs
Hydroxyzine Pamoatecapsule25 mg/1oralProficient Rx LP1996-07-15Not applicableUs
Hydroxyzine Pamoatecapsule50 mg/1oralTYA Pharmaceuticals1996-06-15Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
AtaraxUCB
HyzineHyrex
MasmoranPfizer
RezineNot Available
Vistaject-50Not Available
VistazineNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Hydroxyzine hydrochloride
2192-20-3
Thumb
  • InChI Key: ANOMHKZSQFYSBR-UHFFFAOYNA-N
  • Monoisotopic Mass: 446.129461303
  • Average Mass: 447.826
DBSALT000343
Hydroxyzine pamoate
ThumbNot applicableDBSALT000984
Categories
UNII30S50YM8OG
CAS number68-88-2
WeightAverage: 374.904
Monoisotopic: 374.176105825
Chemical FormulaC21H27ClN2O2
InChI KeyInChIKey=ZQDWXGKKHFNSQK-UHFFFAOYSA-N
InChI
InChI=1S/C21H27ClN2O2/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25/h1-9,21,25H,10-17H2
IUPAC Name
2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)ethan-1-ol
SMILES
OCCOCCN1CCN(CC1)C(C1=CC=CC=C1)C1=CC=C(Cl)C=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassDiphenylmethanes
Direct ParentDiphenylmethanes
Alternative Parents
Substituents
  • Diphenylmethane
  • Aralkylamine
  • N-alkylpiperazine
  • Halobenzene
  • Chlorobenzene
  • Piperazine
  • 1,4-diazinane
  • Aryl halide
  • Aryl chloride
  • Tertiary aliphatic amine
  • Tertiary amine
  • Azacycle
  • Organoheterocyclic compound
  • Ether
  • Dialkyl ether
  • Hydrocarbon derivative
  • Primary alcohol
  • Organooxygen compound
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Amine
  • Alcohol
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationFor symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
PharmacodynamicsHydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine's active metabolite, cetirizine, is also used as an H1-antagonist.
Mechanism of actionHydroxyzine competes with histamine for binding at H1-receptor sites on the effector cell surface, resulting in suppression of histaminic edema, flare, and pruritus. The sedative properties of hydroxyzine occur at the subcortical level of the CNS. Secondary to its central anticholinergic actions, hydroxyzine may be effective as an antiemetic.
Related Articles
AbsorptionRapidly absorbed from the gastrointestinal tract
Volume of distributionNot Available
Protein binding93%
Metabolism

Hepatic

Route of eliminationNot Available
Half life20 to 25 hours
ClearanceNot Available
ToxicityOral, rat LD50: 950 mg/kg. Symptoms of overexposure include hypersedation.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.8623
Blood Brain Barrier+0.9516
Caco-2 permeable-0.5565
P-glycoprotein substrateSubstrate0.7447
P-glycoprotein inhibitor IInhibitor0.8563
P-glycoprotein inhibitor IIInhibitor0.6394
Renal organic cation transporterInhibitor0.592
CYP450 2C9 substrateNon-substrate0.8352
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateNon-substrate0.7193
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorNon-inhibitor0.9111
CYP450 2D6 inhibitorInhibitor0.8535
CYP450 2C19 inhibitorNon-inhibitor0.9026
CYP450 3A4 inhibitorNon-inhibitor0.9623
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7615
Ames testNon AMES toxic0.7558
CarcinogenicityNon-carcinogens0.9102
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.6612 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.5929
hERG inhibition (predictor II)Inhibitor0.7898
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Baxter healthcare corp anesthesia and critical care
  • Altana inc
  • App pharmaceuticals llc
  • Hospira inc
  • Luitpold pharmaceuticals inc
  • Pharmafair inc
  • Smith and nephew solopak div smith and nephew
  • Solopak medical products inc
  • Solopak laboratories inc
  • Watson laboratories inc
  • Wyeth ayerst laboratories
  • Organon usa inc
  • Pfizer laboratories div pfizer inc
  • Roerig div pfizer inc
  • Actavis mid atlantic llc
  • Alpharma us pharmaceuticals division
  • Hi tech pharmacal co inc
  • Kv pharmaceutical co
  • Vintage pharmaceuticals inc
  • Wockhardt eu operations (swiss) ag
  • Pfizer inc
  • Able laboratories inc
  • Actavis totowa llc
  • Amneal pharmaceutical
  • Halsey drug co inc
  • Heritage pharmaceuticals inc
  • Hetero drugs ltd unit iii
  • Invagen pharmaceuticals inc
  • Ivax pharmaceuticals inc
  • Kvk tech inc
  • Mutual pharmaceutical co inc
  • Mylan pharmaceuticals inc
  • Northstar healthcare holdings ltd
  • Pliva inc
  • Purepac pharmaceutical co
  • Quantum pharmics ltd
  • Sandoz inc
  • Sun pharmaceutical industries inc
  • Superpharm corp
  • Usl pharma inc
  • Vintage pharmaceuticals llc
  • Barr laboratories inc
  • Duramed pharmaceuticals inc sub barr laboratories inc
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Par pharmaceutical inc
  • Vangard laboratories inc div midway medical co
  • Teva pharmaceuticals usa inc
Packagers
Dosage forms
FormRouteStrength
Capsuleoral10 mg
Capsuleoral25 mg
Capsuleoral50 mg
Solutionintramuscular50 mg
Syruporal2 mg
Injection, solutionintramuscular25 mg/mL
Injection, solutionintramuscular50 mg/mL
Solutionoral10 mg/5mL
Syruporal10 mg/5mL
Tabletoral10 mg/1
Tabletoral25 mg/1
Tabletoral50 mg/1
Tablet, film coatedoral10 mg/1
Tablet, film coatedoral25 mg/1
Tablet, film coatedoral50 mg/1
Liquidintramuscular50 mg
Capsuleoral100 mg/1
Syruporal10 mg
Capsuleoral25 mg/1
Capsuleoral50 mg/1
Solutionintramuscular50 mg/mL
Prices
Unit descriptionCostUnit
Hydroxyzine Hcl 50 mg/ml4.42USD ml
Hydroxyzine 50 mg/ml vial3.96USD ml
Hydroxyzine 25 mg/ml vial3.6USD ml
Hydroxyzine hcl powder2.75USD g
Hydroxyzine pamoate powder2.14USD g
Vistaril 50 mg capsule2.03USD capsule
HydrOXYzine HCl 50 mg/ml vial1.78USD vial
Vistaril 25 mg capsule1.71USD capsule
Vistaril 100 mg capsule1.7USD capsule
Hydroxyzine hcl 50 mg tablet1.19USD tablet
Hydroxyzine hcl 10 mg tablet0.72USD tablet
Hydroxyzine hcl 25 mg tablet0.7USD tablet
HydrOXYzine Pamoate 100 mg capsule0.67USD capsule
Hydroxyzine pam 50 mg capsule0.64USD capsule
Hydroxyzine pam 100 mg capsule0.63USD capsule
Hydroxyzine pam 25 mg capsule0.46USD capsule
Vistaril 25 mg/5ml Suspension0.45USD ml
HydrOXYzine Pamoate 25 mg capsule0.3USD capsule
HydrOXYzine Pamoate 50 mg capsule0.23USD capsule
Apo-Hydroxyzine 50 mg Capsule0.22USD capsule
Novo-Hydroxyzin 50 mg Capsule0.22USD capsule
Apo-Hydroxyzine 25 mg Capsule0.15USD capsule
Novo-Hydroxyzin 25 mg Capsule0.15USD capsule
HydrOXYzine HCl 10 mg/5ml Syrup0.13USD ml
Apo-Hydroxyzine 10 mg Capsule0.12USD capsule
Novo-Hydroxyzin 10 mg Capsule0.12USD capsule
Atarax 2 mg/ml Syrup0.06USD ml
Pms-Hydroxyzine 2 mg/ml Syrup0.04USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point193 °CU.S. Patent 2,899,436.
water solubility< 700 mg/mLNot Available
logP2.7Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0914 mg/mLALOGPS
logP3.43ALOGPS
logP3.41ChemAxon
logS-3.6ALOGPS
pKa (Strongest Acidic)15.12ChemAxon
pKa (Strongest Basic)7.82ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area35.94 Å2ChemAxon
Rotatable Bond Count8ChemAxon
Refractivity107.07 m3·mol-1ChemAxon
Polarizability41.99 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
MSMass Spectrum (Electron Ionization)splash10-0uxr-4591000000-d2e3424c44feae8a5d9cView in MoNA
References
Synthesis Reference

U.S. Patent 2,899,436.

General References
  1. HUTCHEON DE, MORRIS DL, SCRIABINE A: Cardiovascular action of hydroxyzine (atarax). J Pharmacol Exp Ther. 1956 Dec;118(4):451-60. [PubMed:13385806 ]
  2. DOLAN CM: Management of emotional disturbances; use of hydroxyzine (atarax) in general practice. Calif Med. 1958 Jun;88(6):443-4. [PubMed:13536863 ]
  3. Clark BG, Araki M, Brown HW: Hydroxyzine-associated tardive dyskinesia. Ann Neurol. 1982 Apr;11(4):435. [PubMed:7103423 ]
External Links
ATC CodesN05BB01N05BB51
AHFS Codes
  • 28:24.92
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (73.5 KB)
Interactions
Drug Interactions
Drug
AclidiniumAclidinium may increase the anticholinergic activities of Hydroxyzine.
AlfentanilHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Alfentanil.
AlprazolamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Alprazolam.
AmitriptylineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
AmobarbitalHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Amobarbital.
AmoxapineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Amoxapine.
AmphetamineAmphetamine may decrease the sedative activities of Hydroxyzine.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Hydroxyzine.
AzelastineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
BaclofenHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Baclofen.
Benzylpenicilloyl PolylysineHydroxyzine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
BetahistineThe therapeutic efficacy of Betahistine can be decreased when used in combination with Hydroxyzine.
Botulinum Toxin Type AHydroxyzine may increase the anticholinergic activities of Botulinum Toxin Type A.
Botulinum Toxin Type BHydroxyzine may increase the anticholinergic activities of Botulinum Toxin Type B.
BrexpiprazoleHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Brexpiprazole.
BrimonidineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Brimonidine.
BromazepamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Bromazepam.
BrompheniramineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Brompheniramine.
BuprenorphineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
BuspironeHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Buspirone.
ButabarbitalHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Butabarbital.
ButethalHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Butethal.
ButorphanolHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Butorphanol.
CarbamazepineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Carbamazepine.
CarbinoxamineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Carbinoxamine.
CarisoprodolHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Carisoprodol.
CathinoneCathinone may decrease the sedative activities of Hydroxyzine.
CetirizineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Cetirizine.
ChlordiazepoxideHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.
ChlorphenamineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.
ChlorpromazineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Chlorpromazine.
ChlorzoxazoneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Chlorzoxazone.
Cimetropium BromideHydroxyzine may increase the anticholinergic activities of Cimetropium Bromide.
CitalopramHydroxyzine may increase the QTc-prolonging activities of Citalopram.
ClemastineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Clemastine.
ClobazamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Clobazam.
ClomipramineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Clomipramine.
ClonazepamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Clonazepam.
ClonidineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Clonidine.
ClorazepateHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Clorazepate.
ClozapineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Clozapine.
CyclizineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Cyclizine.
CyclobenzaprineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Cyclobenzaprine.
CyproheptadineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Cyproheptadine.
DantroleneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Dantrolene.
DesfluraneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Desflurane.
DesipramineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
DesloratadineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Desloratadine.
Dexchlorpheniramine maleateHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Dexchlorpheniramine maleate.
DiazepamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Diazepam.
DimenhydrinateHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Dimenhydrinate.
DiphenhydramineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine.
DofetilideHydroxyzine may increase the QTc-prolonging activities of Dofetilide.
DoxepinHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
DoxylamineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Hydroxyzine.
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Hydroxyzine.
EfavirenzHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Efavirenz.
EluxadolineHydroxyzine may increase the activities of Eluxadoline.
EntacaponeHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Entacapone.
EstazolamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Estazolam.
EszopicloneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Eszopiclone.
EthanolHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
EthosuximideHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Ethosuximide.
EthotoinHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Ethotoin.
EzogabineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Ezogabine.
FelbamateHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Felbamate.
FentanylHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Fentanyl.
FexofenadineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.
FlibanserinHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Flibanserin.
FlunarizineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Flunarizine.
FluphenazineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Fluphenazine.
FlurazepamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Flurazepam.
FosphenytoinHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Fosphenytoin.
GabapentinHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Gabapentin.
gabapentin enacarbilHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of gabapentin enacarbil.
Glucagon recombinantThe risk or severity of adverse effects can be increased when Hydroxyzine is combined with Glucagon recombinant.
GoserelinHydroxyzine may increase the QTc-prolonging activities of Goserelin.
GuanfacineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Guanfacine.
HaloperidolHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Haloperidol.
HeptabarbitalHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Heptabarbital.
HexobarbitalHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Hexobarbital.
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Hydroxyzine.
HydrocodoneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
HydromorphoneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Hydromorphone.
ImipramineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Imipramine.
Ipratropium bromideIpratropium bromide may increase the anticholinergic activities of Hydroxyzine.
IsofluraneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Isoflurane.
ItoprideThe therapeutic efficacy of Itopride can be decreased when used in combination with Hydroxyzine.
KetamineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Ketamine.
LamotrigineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Lamotrigine.
LeuprolideHydroxyzine may increase the QTc-prolonging activities of Leuprolide.
LevetiracetamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Levetiracetam.
LevocabastineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Levocabastine.
LevocetirizineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Levocetirizine.
LevorphanolHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Levorphanol.
LoratadineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Loratadine.
LorazepamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Lorazepam.
LoxapineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Loxapine.
LurasidoneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Lurasidone.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Hydroxyzine.
MaprotilineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Maprotiline.
MeclizineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Meclizine.
MeprobamateHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Meprobamate.
MetaxaloneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Metaxalone.
MethadoneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Methadone.
MethocarbamolHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Methocarbamol.
MethohexitalHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Methohexital.
MethotrimeprazineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
MethsuximideHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Methsuximide.
MetyrosineHydroxyzine may increase the sedative activities of Metyrosine.
MianserinMianserin may increase the anticholinergic activities of Hydroxyzine.
MidazolamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Midazolam.
MifepristoneMifepristone may increase the QTc-prolonging activities of Hydroxyzine.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Hydroxyzine.
MirabegronThe risk or severity of adverse effects can be increased when Hydroxyzine is combined with Mirabegron.
MirtazapineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MorphineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Morphine.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Hydroxyzine.
NalbuphineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Nalbuphine.
NitrazepamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Nitrazepam.
Nitrous oxideHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.
NortriptylineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Nortriptyline.
OlanzapineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Olanzapine.
OlopatadineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Olopatadine.
OrphenadrineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
OxazepamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Oxazepam.
OxycodoneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Oxycodone.
OxymorphoneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Oxymorphone.
ParaldehydeHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParoxetineThe risk or severity of adverse effects can be increased when Hydroxyzine is combined with Paroxetine.
PentazocineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Pentazocine.
PentobarbitalHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Pentobarbital.
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Hydroxyzine.
PerphenazineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Perphenazine.
PethidineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Pethidine.
PhenobarbitalHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Phenobarbital.
PhenytoinHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Phenytoin.
PipotiazineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Pipotiazine.
PizotifenHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Pizotifen.
PomalidomideHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Pomalidomide.
Potassium ChlorideHydroxyzine may increase the ulcerogenic activities of Potassium Chloride.
PramipexoleHydroxyzine may increase the sedative activities of Pramipexole.
PramlintidePramlintide may increase the anticholinergic activities of Hydroxyzine.
PregabalinHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.
PrimidoneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Primidone.
ProchlorperazineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Prochlorperazine.
ProcyclidineThe risk or severity of adverse effects can be increased when Procyclidine is combined with Hydroxyzine.
PromazineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Promazine.
PromethazineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Promethazine.
PropofolHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Propofol.
ProtriptylineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Protriptyline.
QuazepamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Quazepam.
RamelteonHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Ramelteon.
RamosetronHydroxyzine may increase the activities of Ramosetron.
RemifentanilHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Remifentanil.
ReserpineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Reserpine.
RisperidoneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Risperidone.
RopiniroleHydroxyzine may increase the sedative activities of Ropinirole.
RotigotineHydroxyzine may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Hydroxyzine.
ScopolamineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Scopolamine.
Scopolamine butylbromideHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Scopolamine butylbromide.
SecobarbitalHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Secobarbital.
SecretinThe therapeutic efficacy of Secretin can be decreased when used in combination with Hydroxyzine.
SevofluraneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Sevoflurane.
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Hydroxyzine.
StiripentolHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Stiripentol.
SufentanilHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Sufentanil.
SulpirideThe therapeutic efficacy of Sulpiride can be decreased when used in combination with Hydroxyzine.
SuvorexantHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
TacrineThe therapeutic efficacy of Hydroxyzine can be decreased when used in combination with Tacrine.
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Hydroxyzine.
TasimelteonHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Tasimelteon.
TemazepamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Temazepam.
ThalidomideHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
ThiothixeneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Thiothixene.
TiagabineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Tiagabine.
TiotropiumHydroxyzine may increase the anticholinergic activities of Tiotropium.
TizanidineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Tizanidine.
TolcaponeHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Tolcapone.
TopiramateHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Topiramate.
TramadolHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Tramadol.
TriazolamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Triazolam.
TrichlormethiazideThe serum concentration of Trichlormethiazide can be increased when it is combined with Hydroxyzine.
TrifluoperazineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Trifluoperazine.
TrimipramineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Trimipramine.
TriprolidineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Triprolidine.
UmeclidiniumUmeclidinium may increase the anticholinergic activities of Hydroxyzine.
VigabatrinHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Vigabatrin.
ZaleplonHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Zaleplon.
ZiconotideHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Ziconotide.
ZolpidemHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
ZonisamideHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Zonisamide.
ZopicloneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Zopiclone.
Food Interactions
  • Avoid alcohol.
  • Take with food.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Histamine receptor activity
Specific Function:
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
Gene Name:
HRH1
Uniprot ID:
P35367
Molecular Weight:
55783.61 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. Spahr L, Coeytaux A, Giostra E, Hadengue A, Annoni JM: Histamine H1 blocker hydroxyzine improves sleep in patients with cirrhosis and minimal hepatic encephalopathy: a randomized controlled pilot trial. Am J Gastroenterol. 2007 Apr;102(4):744-53. Epub 2007 Jan 11. [PubMed:17222324 ]
  3. Sakaguchi T, Itoh H, Ding WG, Tsuji K, Nagaoka I, Oka Y, Ashihara T, Ito M, Yumoto Y, Zenda N, Higashi Y, Takeyama Y, Matsuura H, Horie M: Hydroxyzine, a first generation H(1)-receptor antagonist, inhibits human ether-a-go-go-related gene (HERG) current and causes syncope in a patient with the HERG mutation. J Pharmacol Sci. 2008 Dec;108(4):462-71. Epub 2008 Dec 5. [PubMed:19057127 ]
  4. Chen C: Physicochemical, pharmacological and pharmacokinetic properties of the zwitterionic antihistamines cetirizine and levocetirizine. Curr Med Chem. 2008;15(21):2173-91. [PubMed:18781943 ]
  5. Snowman AM, Snyder SH: Cetirizine: actions on neurotransmitter receptors. J Allergy Clin Immunol. 1990 Dec;86(6 Pt 2):1025-8. [PubMed:1979798 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Hamelin BA, Bouayad A, Drolet B, Gravel A, Turgeon J: In vitro characterization of cytochrome P450 2D6 inhibition by classic histamine H1 receptor antagonists. Drug Metab Dispos. 1998 Jun;26(6):536-9. [PubMed:9616188 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
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Drug created on June 13, 2005 07:24 / Updated on April 29, 2014 17:39