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Identification
NameNafcillin
Accession NumberDB00607  (APRD01130, DB08269)
TypeSmall Molecule
GroupsApproved
DescriptionA semi-synthetic antibiotic related to penicillin. [PubChem]
Structure
Thumb
Synonyms
(2-Ethoxy-1-naphthalenyl)penicillin
(2-Ethoxy-1-naphthyl)penicillin
(2S,5R,6R)-6-{[(2-ethoxynaphthalen-1-yl)carbonyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
6-(2-Ethoxy-1-naphthamido)penicillanic acid
Nafcilina
Nafcilline
Nafcillinum
Naphcillin
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Nafcillininjection, solution1 g/50mLintravenousBaxter Healthcare Corporation1989-10-31Not applicableUs
Nafcillininjection, solution2 g/100mLintravenousBaxter Healthcare Corporation1989-10-31Not applicableUs
Unipen Injection Pws 500mg/vialpowder for solution500 mgintramuscular; intravenousWyeth Ayerst Canada Inc.1994-12-311998-08-13Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Nafcillininjection, powder, for solution1 g/1intramuscular; intravenousSandoz Inc1984-08-02Not applicableUs
Nafcillininjection, powder, for solution10 g/100mLintravenousAuro Medics Pharma Llc2012-12-26Not applicableUs
Nafcillininjection1 g/1intramuscular; intravenousClaris Lifesciences, Inc.2012-02-01Not applicableUs
Nafcillininjection, powder, for solution10 g/100mLintravenousWG Critical Care, LLC2011-04-27Not applicableUs
Nafcillininjection, powder, for solution10 g/100mLintravenousSandoz Inc1984-08-02Not applicableUs
Nafcillinpowder, for solution1 g/4mLintramuscular; intravenousAPP Pharmaceuticals, LLC2011-06-30Not applicableUs
Nafcillininjection, powder, for solution2 g/1intramuscular; intravenousSandoz Inc1984-08-02Not applicableUs
Nafcillininjection2 g/1intramuscular; intravenousClaris Lifesciences, Inc.2012-02-01Not applicableUs
Nafcillininjection, powder, for solution1 g/4mLintramuscular; intravenousSagent Pharmaceuticals2012-10-25Not applicableUs
Nafcillininjection, powder, for solution1 g/4mLintramuscular; intravenousAuro Medics Pharma Llc2012-12-26Not applicableUs
Nafcillinpowder, for solution2 g/8mLintramuscular; intravenousAPP Pharmaceuticals, LLC2011-06-30Not applicableUs
Nafcillininjection, powder, for solution10 g/100mLintravenousSandoz Inc1984-08-02Not applicableUs
Nafcillinpowder, for solution1 g/1intramuscular; intravenousWG Critical Care, LLC2013-01-18Not applicableUs
Nafcillininjection, powder, for solution1 g/1intramuscular; intravenousSandoz Inc1984-08-02Not applicableUs
Nafcillininjection, powder, for solution2 g/8mLintramuscular; intravenousSagent Pharmaceuticals2012-10-25Not applicableUs
Nafcillininjection, powder, for solution2 g/8mLintramuscular; intravenousAuro Medics Pharma Llc2012-12-26Not applicableUs
Nafcillininjection, powder, for solution10 g/100mLintravenousAPP Pharmaceuticals, LLC2011-04-27Not applicableUs
Nafcillinpowder, for solution2 g/1intramuscular; intravenousWG Critical Care, LLC2013-01-18Not applicableUs
Nafcillininjection, powder, for solution2 g/1intramuscular; intravenousSandoz Inc1984-08-02Not applicableUs
Nafcillininjection, powder, for solution10 g/100mLintravenousSagent Pharmaceuticals2012-10-25Not applicableUs
Nafcillin Sodiuminjection, powder, for solution1 g/4mLintramuscular; intravenousTeva Parenteral Medicines, Inc.2014-04-08Not applicableUs
Nafcillin Sodiuminjection, powder, for solution2 g/1intravenousSandoz Inc2005-09-23Not applicableUs
Nafcillin Sodiuminjection, powder, for solution2 g/8mLintramuscular; intravenousTeva Parenteral Medicines, Inc.2014-04-09Not applicableUs
Nafcillin Sodiuminjection, powder, for solution1 g/1intravenousSandoz Inc2005-09-23Not applicableUs
Nafcillin Sodiuminjection, powder, for solution2 g/1intravenousSandoz Inc2005-09-23Not applicableUs
Nafcillin Sodiuminjection, powder, for solution1 g/1intravenousSandoz Inc2005-09-23Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
NallpenNot Available
UnipenNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Nafcillin Sodium
985-16-0
Thumb
  • InChI Key: AYAPZOUDXCDGIF-FRFVDRIFSA-M
  • Monoisotopic Mass: 436.106887157
  • Average Mass: 436.457
DBSALT000497
Categories
UNII4CNZ27M7RV
CAS number147-52-4
WeightAverage: 414.475
Monoisotopic: 414.124942514
Chemical FormulaC21H22N2O5S
InChI KeyInChIKey=GPXLMGHLHQJAGZ-JTDSTZFVSA-N
InChI
InChI=1S/C21H22N2O5S/c1-4-28-13-10-9-11-7-5-6-8-12(11)14(13)17(24)22-15-18(25)23-16(20(26)27)21(2,3)29-19(15)23/h5-10,15-16,19H,4H2,1-3H3,(H,22,24)(H,26,27)/t15-,16+,19-/m1/s1
IUPAC Name
(2S,5R,6R)-6-(2-ethoxynaphthalene-1-amido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
SMILES
[H][C@]12SC(C)(C)[C@@H](N1C(=O)[[email protected]]2NC(=O)C1=C(OCC)C=CC2=CC=CC=C12)C(O)=O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as penicillins. These are organic compounds containing the penicillin core structure, which is structurally characterized by a penam ring bearing two methyl groups at position 2, and an amide group at position 6 [starting from the sulfur atom at position 1].
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassLactams
Sub ClassBeta lactams
Direct ParentPenicillins
Alternative Parents
Substituents
  • Penicillin
  • 1-naphthalenecarboxylic acid or derivatives
  • 1-naphthalenecarboxamide
  • N-acyl-alpha amino acid or derivatives
  • Naphthalene
  • Alpha-amino acid or derivatives
  • Benzamide
  • Benzoyl
  • Alkyl aryl ether
  • Benzenoid
  • Thiazolidine
  • Tertiary carboxylic acid amide
  • Tertiary amine
  • Secondary carboxylic acid amide
  • Carboxamide group
  • Azetidine
  • Azacycle
  • Dialkylthioether
  • Hemithioaminal
  • Thioether
  • Monocarboxylic acid or derivatives
  • Ether
  • Carboxylic acid
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of infections caused by penicillinase-producing staphylococci which have demonstrated susceptibility to the drugs.
PharmacodynamicsNafcillin is a semisynthetic antibiotic substance derived from 6-amino-penicillanic acid. The drugs in this class are highly resistant to inactivation by staphylococcal penicillinase and are active against penicillinase-producing and non penicillinase-producing strains of Staphylococcus aureus. The penicillinase- resistant penicillins are active in vitro against a variety of other bacteria.
Mechanism of actionPenicillinase-resistant penicillins exert a bactericidal action against penicillin-susceptible microorganisms during the state of active multiplication. All penicillins inhibit the biosynthesis of the bacterial cell wall.
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein binding89.9 ±1.5%
Metabolism

Hepatic metabolism accounts for less than 30% of the biotransformation of most penicillins.

Route of eliminationNafcillin is primarily eliminated by nonrenal routes, namely hepatic inactivation and excretion in the bile.
Half lifeThe serum half-life of nafcillin administered by the intravenous route ranged from 33 to 61 minutes as measured in three separate studies.
ClearanceNot Available
ToxicitySerious toxicity is unlikely following large doses of nafcillin. Acute ingestion of large doses of nafcillin may cause nausea, vomiting, diarrhea and abdominal pain. Acute oliguric renal failure and hematuria may occur following large doses.
Affected organisms
  • Enteric bacteria and other eubacteria
  • Staphylococcus aureus
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption-0.5328
Blood Brain Barrier-0.9938
Caco-2 permeable-0.6248
P-glycoprotein substrateSubstrate0.708
P-glycoprotein inhibitor INon-inhibitor0.8782
P-glycoprotein inhibitor IINon-inhibitor0.8807
Renal organic cation transporterNon-inhibitor0.923
CYP450 2C9 substrateNon-substrate0.7898
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateNon-substrate0.5
CYP450 1A2 substrateNon-inhibitor0.8164
CYP450 2C9 inhibitorNon-inhibitor0.7263
CYP450 2D6 inhibitorNon-inhibitor0.8869
CYP450 2C19 inhibitorNon-inhibitor0.8082
CYP450 3A4 inhibitorInhibitor0.5653
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7437
Ames testNon AMES toxic0.796
CarcinogenicityNon-carcinogens0.6679
BiodegradationNot ready biodegradable0.9972
Rat acute toxicity2.1208 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9994
hERG inhibition (predictor II)Non-inhibitor0.6449
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Wyeth ayerst laboratories
  • Apothecon inc div bristol myers squibb
  • Marsam pharmaceuticals llc
  • Sandoz inc
  • Glaxosmithkline
  • Baxter healthcare corp
Packagers
Dosage forms
FormRouteStrength
Injectionintramuscular; intravenous1 g/1
Injectionintramuscular; intravenous2 g/1
Injection, powder, for solutionintramuscular; intravenous1 g/1
Injection, powder, for solutionintramuscular; intravenous2 g/1
Injection, powder, for solutionintravenous10 g/100mL
Injection, solutionintravenous1 g/50mL
Injection, solutionintravenous2 g/100mL
Powder, for solutionintramuscular; intravenous1 g/4mL
Powder, for solutionintramuscular; intravenous1 g/1
Powder, for solutionintramuscular; intravenous2 g/8mL
Powder, for solutionintramuscular; intravenous2 g/1
Injection, powder, for solutionintramuscular; intravenous1 g/4mL
Injection, powder, for solutionintramuscular; intravenous2 g/8mL
Injection, powder, for solutionintravenous1 g/1
Injection, powder, for solutionintravenous2 g/1
Powder for solutionintramuscular; intravenous500 mg
Prices
Unit descriptionCostUnit
Nafcillin 10 gm vial118.01USD vial
Nafcillin 2 gm vial24.08USD vial
Nafcillin 1 gm vial12.41USD vial
Nafcillin 1 gm/ 50 ml inj0.43USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
water solubilitySolubleNot Available
logP3.3Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0172 mg/mLALOGPS
logP3.21ALOGPS
logP2.29ChemAxon
logS-4.4ALOGPS
pKa (Strongest Acidic)3.31ChemAxon
pKa (Strongest Basic)-1.6ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area95.94 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity108.14 m3·mol-1ChemAxon
Polarizability42.22 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesJ01CF06
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (44.1 KB)
Interactions
Drug Interactions
Drug
AbirateroneThe serum concentration of Abiraterone can be decreased when it is combined with Nafcillin.
AcenocoumarolNafcillin may increase the anticoagulant activities of Acenocoumarol.
AcetaminophenThe serum concentration of Acetaminophen can be decreased when it is combined with Nafcillin.
AdinazolamThe serum concentration of Adinazolam can be decreased when it is combined with Nafcillin.
AlbendazoleThe serum concentration of Albendazole can be decreased when it is combined with Nafcillin.
AlclometasoneThe serum concentration of Alclometasone can be decreased when it is combined with Nafcillin.
AlfentanilThe serum concentration of Alfentanil can be decreased when it is combined with Nafcillin.
AlfuzosinThe serum concentration of Alfuzosin can be decreased when it is combined with Nafcillin.
AliskirenThe serum concentration of Aliskiren can be decreased when it is combined with Nafcillin.
AllylestrenolThe serum concentration of Allylestrenol can be decreased when it is combined with Nafcillin.
AlmotriptanThe serum concentration of Almotriptan can be decreased when it is combined with Nafcillin.
AlogliptinThe serum concentration of Alogliptin can be decreased when it is combined with Nafcillin.
AlosetronThe serum concentration of Alosetron can be decreased when it is combined with Nafcillin.
AlprazolamThe serum concentration of Alprazolam can be decreased when it is combined with Nafcillin.
AmbrisentanThe serum concentration of Ambrisentan can be decreased when it is combined with Nafcillin.
AmbroxolThe serum concentration of Ambroxol can be decreased when it is combined with Nafcillin.
AmikacinThe serum concentration of Amikacin can be decreased when it is combined with Nafcillin.
AminophenazoneThe serum concentration of Aminophenazone can be decreased when it is combined with Nafcillin.
AminophyllineThe serum concentration of Aminophylline can be decreased when it is combined with Nafcillin.
AmiodaroneThe serum concentration of Amiodarone can be decreased when it is combined with Nafcillin.
AmitriptylineThe serum concentration of Amitriptyline can be decreased when it is combined with Nafcillin.
AmlodipineThe serum concentration of Amlodipine can be decreased when it is combined with Nafcillin.
AmprenavirThe serum concentration of Amprenavir can be decreased when it is combined with Nafcillin.
AmrinoneThe metabolism of Amrinone can be increased when combined with Nafcillin.
AntipyrineThe serum concentration of Antipyrine can be decreased when it is combined with Nafcillin.
ApixabanThe serum concentration of Apixaban can be decreased when it is combined with Nafcillin.
ApremilastThe serum concentration of Apremilast can be decreased when it is combined with Nafcillin.
AprepitantThe serum concentration of Aprepitant can be decreased when it is combined with Nafcillin.
ArgatrobanThe serum concentration of Argatroban can be decreased when it is combined with Nafcillin.
AripiprazoleThe serum concentration of Aripiprazole can be decreased when it is combined with Nafcillin.
ArtemetherThe serum concentration of Artemether can be decreased when it is combined with Nafcillin.
AsenapineThe serum concentration of Asenapine can be decreased when it is combined with Nafcillin.
AstemizoleThe serum concentration of Astemizole can be decreased when it is combined with Nafcillin.
AtazanavirThe serum concentration of Atazanavir can be decreased when it is combined with Nafcillin.
AtorvastatinThe serum concentration of Atorvastatin can be decreased when it is combined with Nafcillin.
AvanafilThe serum concentration of Avanafil can be decreased when it is combined with Nafcillin.
AxitinibThe serum concentration of Axitinib can be decreased when it is combined with Nafcillin.
AzelastineThe serum concentration of Azelastine can be decreased when it is combined with Nafcillin.
AzelnidipineThe metabolism of Azelnidipine can be increased when combined with Nafcillin.
AzimilideThe metabolism of Azimilide can be increased when combined with Nafcillin.
AzithromycinThe serum concentration of Azithromycin can be decreased when it is combined with Nafcillin.
BanoxantroneThe serum concentration of Banoxantrone can be decreased when it is combined with Nafcillin.
BarnidipineThe metabolism of Barnidipine can be increased when combined with Nafcillin.
BedaquilineThe serum concentration of Bedaquiline can be decreased when it is combined with Nafcillin.
BenidipineThe metabolism of Benidipine can be increased when combined with Nafcillin.
BenzphetamineThe serum concentration of Benzphetamine can be decreased when it is combined with Nafcillin.
Benzyl alcoholThe serum concentration of Benzyl alcohol can be decreased when it is combined with Nafcillin.
BepridilThe metabolism of Bepridil can be increased when combined with Nafcillin.
BexaroteneThe serum concentration of Bexarotene can be decreased when it is combined with Nafcillin.
BezafibrateThe serum concentration of Bezafibrate can be decreased when it is combined with Nafcillin.
BicalutamideThe serum concentration of Bicalutamide can be decreased when it is combined with Nafcillin.
BisoprololThe serum concentration of Bisoprolol can be decreased when it is combined with Nafcillin.
BoceprevirThe serum concentration of Boceprevir can be decreased when it is combined with Nafcillin.
BortezomibThe serum concentration of Bortezomib can be decreased when it is combined with Nafcillin.
BosentanThe serum concentration of Bosentan can be decreased when it is combined with Nafcillin.
BosutinibThe serum concentration of Bosutinib can be decreased when it is combined with Nafcillin.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be decreased when it is combined with Nafcillin.
BrexpiprazoleThe serum concentration of Brexpiprazole can be decreased when it is combined with Nafcillin.
BrinzolamideThe serum concentration of Brinzolamide can be decreased when it is combined with Nafcillin.
BromazepamThe serum concentration of Bromazepam can be decreased when it is combined with Nafcillin.
BromocriptineThe serum concentration of Bromocriptine can be decreased when it is combined with Nafcillin.
BrompheniramineThe serum concentration of Brompheniramine can be decreased when it is combined with Nafcillin.
BudesonideThe serum concentration of Budesonide can be decreased when it is combined with Nafcillin.
BupivacaineThe serum concentration of Bupivacaine can be decreased when it is combined with Nafcillin.
BuprenorphineThe serum concentration of Buprenorphine can be decreased when it is combined with Nafcillin.
BupropionThe serum concentration of Bupropion can be decreased when it is combined with Nafcillin.
BuspironeThe serum concentration of Buspirone can be decreased when it is combined with Nafcillin.
BusulfanThe serum concentration of Busulfan can be decreased when it is combined with Nafcillin.
CabazitaxelThe serum concentration of Cabazitaxel can be decreased when it is combined with Nafcillin.
CabergolineThe serum concentration of Cabergoline can be decreased when it is combined with Nafcillin.
CabozantinibThe serum concentration of Cabozantinib can be decreased when it is combined with Nafcillin.
CaffeineThe serum concentration of Caffeine can be decreased when it is combined with Nafcillin.
CalcitriolThe serum concentration of Calcitriol can be decreased when it is combined with Nafcillin.
CanagliflozinThe serum concentration of Canagliflozin can be decreased when it is combined with Nafcillin.
CarbamazepineThe serum concentration of Carbamazepine can be decreased when it is combined with Nafcillin.
CarbinoxamineThe serum concentration of Carbinoxamine can be decreased when it is combined with Nafcillin.
CariprazineThe serum concentration of Cariprazine can be decreased when it is combined with Nafcillin.
CarvedilolThe serum concentration of Carvedilol can be decreased when it is combined with Nafcillin.
CelecoxibThe serum concentration of Celecoxib can be decreased when it is combined with Nafcillin.
CeliprololThe serum concentration of Celiprolol can be decreased when it is combined with Nafcillin.
CephalexinThe serum concentration of Cephalexin can be decreased when it is combined with Nafcillin.
CerivastatinThe serum concentration of Cerivastatin can be decreased when it is combined with Nafcillin.
CevimelineThe serum concentration of Cevimeline can be decreased when it is combined with Nafcillin.
Chenodeoxycholic acidThe serum concentration of Chenodeoxycholic acid can be decreased when it is combined with Nafcillin.
ChlordiazepoxideThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Nafcillin.
ChloroquineThe serum concentration of Chloroquine can be decreased when it is combined with Nafcillin.
ChlorphenamineThe serum concentration of Chlorphenamine can be decreased when it is combined with Nafcillin.
ChlorpromazineThe serum concentration of Chlorpromazine can be decreased when it is combined with Nafcillin.
ChlorzoxazoneThe serum concentration of Chlorzoxazone can be decreased when it is combined with Nafcillin.
CholecalciferolThe serum concentration of Cholecalciferol can be decreased when it is combined with Nafcillin.
CiclesonideThe serum concentration of Ciclesonide can be decreased when it is combined with Nafcillin.
CilnidipineThe metabolism of Cilnidipine can be increased when combined with Nafcillin.
CilostazolThe serum concentration of Cilostazol can be decreased when it is combined with Nafcillin.
CinacalcetThe serum concentration of Cinacalcet can be decreased when it is combined with Nafcillin.
CinnarizineThe metabolism of Cinnarizine can be increased when combined with Nafcillin.
CisaprideThe serum concentration of Cisapride can be decreased when it is combined with Nafcillin.
CitalopramThe serum concentration of Citalopram can be decreased when it is combined with Nafcillin.
ClarithromycinThe serum concentration of Clarithromycin can be decreased when it is combined with Nafcillin.
ClevidipineThe metabolism of Clevidipine can be increased when combined with Nafcillin.
ClindamycinThe serum concentration of Clindamycin can be decreased when it is combined with Nafcillin.
ClobazamThe serum concentration of Clobazam can be decreased when it is combined with Nafcillin.
ClofazimineThe serum concentration of Clofazimine can be decreased when it is combined with Nafcillin.
ClofibrateThe serum concentration of Clofibrate can be decreased when it is combined with Nafcillin.
clomethiazoleThe serum concentration of clomethiazole can be decreased when it is combined with Nafcillin.
ClomipramineThe serum concentration of Clomipramine can be decreased when it is combined with Nafcillin.
ClonazepamThe serum concentration of Clonazepam can be decreased when it is combined with Nafcillin.
ClonidineThe serum concentration of Clonidine can be decreased when it is combined with Nafcillin.
ClopidogrelThe serum concentration of Clopidogrel can be decreased when it is combined with Nafcillin.
ClorazepateThe serum concentration of Clorazepate can be decreased when it is combined with Nafcillin.
ClotiazepamThe serum concentration of Clotiazepam can be decreased when it is combined with Nafcillin.
ClozapineThe serum concentration of Clozapine can be decreased when it is combined with Nafcillin.
CobimetinibThe serum concentration of Cobimetinib can be decreased when it is combined with Nafcillin.
CocaineThe serum concentration of Cocaine can be decreased when it is combined with Nafcillin.
CodeineThe serum concentration of Codeine can be decreased when it is combined with Nafcillin.
ColchicineThe serum concentration of Colchicine can be decreased when it is combined with Nafcillin.
ConivaptanThe serum concentration of Conivaptan can be decreased when it is combined with Nafcillin.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be decreased when it is combined with Nafcillin.
Cortisone acetateThe serum concentration of Cortisone acetate can be decreased when it is combined with Nafcillin.
CrizotinibThe serum concentration of Crizotinib can be decreased when it is combined with Nafcillin.
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be decreased when it is combined with Nafcillin.
CyclophosphamideThe serum concentration of Cyclophosphamide can be decreased when it is combined with Nafcillin.
CyclosporineThe metabolism of Cyclosporine can be increased when combined with Nafcillin.
CytarabineThe serum concentration of Cytarabine can be decreased when it is combined with Nafcillin.
DabrafenibThe serum concentration of Dabrafenib can be decreased when it is combined with Nafcillin.
DaclatasvirThe serum concentration of Daclatasvir can be decreased when it is combined with Nafcillin.
DantroleneThe serum concentration of Dantrolene can be decreased when it is combined with Nafcillin.
DapagliflozinThe serum concentration of Dapagliflozin can be decreased when it is combined with Nafcillin.
DapsoneThe serum concentration of Dapsone can be decreased when it is combined with Nafcillin.
DarifenacinThe serum concentration of Darifenacin can be decreased when it is combined with Nafcillin.
DarodipineThe metabolism of Darodipine can be increased when combined with Nafcillin.
DarunavirThe serum concentration of Darunavir can be decreased when it is combined with Nafcillin.
DasabuvirThe serum concentration of Dasabuvir can be decreased when it is combined with Nafcillin.
DasatinibThe serum concentration of Dasatinib can be decreased when it is combined with Nafcillin.
DaunorubicinThe serum concentration of Daunorubicin can be decreased when it is combined with Nafcillin.
DehydroepiandrosteroneThe serum concentration of Dehydroepiandrosterone can be decreased when it is combined with Nafcillin.
DelavirdineThe serum concentration of Delavirdine can be decreased when it is combined with Nafcillin.
DesvenlafaxineThe serum concentration of Desvenlafaxine can be decreased when it is combined with Nafcillin.
DexamethasoneThe serum concentration of Dexamethasone can be decreased when it is combined with Nafcillin.
DextromethorphanThe serum concentration of Dextromethorphan can be decreased when it is combined with Nafcillin.
DextropropoxypheneThe serum concentration of Dextropropoxyphene can be decreased when it is combined with Nafcillin.
DiazepamThe serum concentration of Diazepam can be decreased when it is combined with Nafcillin.
DiclofenacThe serum concentration of Diclofenac can be decreased when it is combined with Nafcillin.
DicoumarolNafcillin may increase the anticoagulant activities of Dicoumarol.
DigitoxinThe serum concentration of Digitoxin can be decreased when it is combined with Nafcillin.
DigoxinThe serum concentration of Digoxin can be decreased when it is combined with Nafcillin.
DihydrocodeineThe serum concentration of Dihydrocodeine can be decreased when it is combined with Nafcillin.
DihydroergotamineThe serum concentration of Dihydroergotamine can be decreased when it is combined with Nafcillin.
DihydrostreptomycinThe serum concentration of Dihydrostreptomycin can be decreased when it is combined with Nafcillin.
DiltiazemThe serum concentration of Diltiazem can be decreased when it is combined with Nafcillin.
DisopyramideThe serum concentration of Disopyramide can be decreased when it is combined with Nafcillin.
DisulfiramThe serum concentration of Disulfiram can be decreased when it is combined with Nafcillin.
DocetaxelThe serum concentration of Docetaxel can be decreased when it is combined with Nafcillin.
DofetilideThe serum concentration of Dofetilide can be decreased when it is combined with Nafcillin.
DolasetronThe serum concentration of Dolasetron can be decreased when it is combined with Nafcillin.
DomperidoneThe serum concentration of Domperidone can be decreased when it is combined with Nafcillin.
DonepezilThe serum concentration of Donepezil can be decreased when it is combined with Nafcillin.
DorzolamideThe serum concentration of Dorzolamide can be decreased when it is combined with Nafcillin.
DotarizineThe metabolism of Dotarizine can be increased when combined with Nafcillin.
DoxepinThe serum concentration of Doxepin can be decreased when it is combined with Nafcillin.
DoxorubicinThe serum concentration of Doxorubicin can be decreased when it is combined with Nafcillin.
DronabinolThe serum concentration of Dronabinol can be decreased when it is combined with Nafcillin.
DronedaroneThe serum concentration of Dronedarone can be decreased when it is combined with Nafcillin.
DutasterideThe serum concentration of Dutasteride can be decreased when it is combined with Nafcillin.
EfavirenzThe serum concentration of Efavirenz can be decreased when it is combined with Nafcillin.
EfonidipineThe metabolism of Efonidipine can be increased when combined with Nafcillin.
EletriptanThe serum concentration of Eletriptan can be decreased when it is combined with Nafcillin.
EliglustatThe serum concentration of Eliglustat can be decreased when it is combined with Nafcillin.
ElvitegravirThe serum concentration of Elvitegravir can be decreased when it is combined with Nafcillin.
EnalaprilThe serum concentration of Enalapril can be decreased when it is combined with Nafcillin.
EnzalutamideThe serum concentration of Enzalutamide can be decreased when it is combined with Nafcillin.
EperisoneThe metabolism of Eperisone can be increased when combined with Nafcillin.
EpinastineThe serum concentration of Epinastine can be decreased when it is combined with Nafcillin.
EpirubicinThe serum concentration of Epirubicin can be decreased when it is combined with Nafcillin.
EplerenoneThe serum concentration of Eplerenone can be decreased when it is combined with Nafcillin.
ErgocalciferolThe serum concentration of Ergocalciferol can be decreased when it is combined with Nafcillin.
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be decreased when it is combined with Nafcillin.
ErgonovineThe serum concentration of Ergonovine can be decreased when it is combined with Nafcillin.
ErgotamineThe serum concentration of Ergotamine can be decreased when it is combined with Nafcillin.
ErlotinibThe serum concentration of Erlotinib can be decreased when it is combined with Nafcillin.
ErythromycinThe serum concentration of Erythromycin can be decreased when it is combined with Nafcillin.
EscitalopramThe serum concentration of Escitalopram can be decreased when it is combined with Nafcillin.
EsomeprazoleThe serum concentration of Esomeprazole can be decreased when it is combined with Nafcillin.
EstazolamThe serum concentration of Estazolam can be decreased when it is combined with Nafcillin.
EstradiolThe serum concentration of Estradiol can be decreased when it is combined with Nafcillin.
Estradiol valerate/DienogestThe serum concentration of Estradiol valerate/Dienogest can be decreased when it is combined with Nafcillin.
EstramustineThe serum concentration of Estramustine can be decreased when it is combined with Nafcillin.
EstroneThe serum concentration of Estrone can be decreased when it is combined with Nafcillin.
Estrone sulfateThe serum concentration of Estrone sulfate can be decreased when it is combined with Nafcillin.
EszopicloneThe serum concentration of Eszopiclone can be decreased when it is combined with Nafcillin.
EthanolThe serum concentration of Ethanol can be decreased when it is combined with Nafcillin.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Nafcillin.
EthosuximideThe serum concentration of Ethosuximide can be decreased when it is combined with Nafcillin.
Ethyl biscoumacetateNafcillin may increase the anticoagulant activities of Ethyl biscoumacetate.
EthylmorphineThe serum concentration of Ethylmorphine can be decreased when it is combined with Nafcillin.
EtonogestrelThe serum concentration of Etonogestrel can be decreased when it is combined with Nafcillin.
EtoposideThe serum concentration of Etoposide can be decreased when it is combined with Nafcillin.
EtoricoxibThe serum concentration of Etoricoxib can be decreased when it is combined with Nafcillin.
EtravirineThe serum concentration of Etravirine can be decreased when it is combined with Nafcillin.
EverolimusThe serum concentration of Everolimus can be decreased when it is combined with Nafcillin.
ExemestaneThe serum concentration of Exemestane can be decreased when it is combined with Nafcillin.
FamciclovirThe serum concentration of Famciclovir can be decreased when it is combined with Nafcillin.
FelbamateThe serum concentration of Felbamate can be decreased when it is combined with Nafcillin.
FelodipineThe serum concentration of Felodipine can be decreased when it is combined with Nafcillin.
FendilineThe metabolism of Fendiline can be increased when combined with Nafcillin.
FenofibrateThe serum concentration of Fenofibrate can be decreased when it is combined with Nafcillin.
FentanylThe serum concentration of Fentanyl can be decreased when it is combined with Nafcillin.
FesoterodineThe serum concentration of Fesoterodine can be decreased when it is combined with Nafcillin.
FinasterideThe serum concentration of Finasteride can be decreased when it is combined with Nafcillin.
FingolimodThe serum concentration of Fingolimod can be decreased when it is combined with Nafcillin.
FlibanserinThe serum concentration of Flibanserin can be decreased when it is combined with Nafcillin.
FlunarizineThe metabolism of Flunarizine can be increased when combined with Nafcillin.
FlunisolideThe serum concentration of Flunisolide can be decreased when it is combined with Nafcillin.
FlunitrazepamThe serum concentration of Flunitrazepam can be decreased when it is combined with Nafcillin.
FluorometholoneThe serum concentration of Fluorometholone can be decreased when it is combined with Nafcillin.
FluoxetineThe serum concentration of Fluoxetine can be decreased when it is combined with Nafcillin.
FlurazepamThe serum concentration of Flurazepam can be decreased when it is combined with Nafcillin.
FlutamideThe serum concentration of Flutamide can be decreased when it is combined with Nafcillin.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be decreased when it is combined with Nafcillin.
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be decreased when it is combined with Nafcillin.
FluvastatinThe serum concentration of Fluvastatin can be decreased when it is combined with Nafcillin.
FosamprenavirThe serum concentration of Fosamprenavir can be decreased when it is combined with Nafcillin.
FramycetinThe serum concentration of Framycetin can be decreased when it is combined with Nafcillin.
FulvestrantThe serum concentration of Fulvestrant can be decreased when it is combined with Nafcillin.
GabapentinThe metabolism of Gabapentin can be increased when combined with Nafcillin.
GalantamineThe serum concentration of Galantamine can be decreased when it is combined with Nafcillin.
GefitinibThe serum concentration of Gefitinib can be decreased when it is combined with Nafcillin.
GemfibrozilThe serum concentration of Gemfibrozil can be decreased when it is combined with Nafcillin.
GentamicinThe serum concentration of Gentamicin can be decreased when it is combined with Nafcillin.
GlipizideThe serum concentration of Glipizide can be decreased when it is combined with Nafcillin.
GlyburideThe serum concentration of Glyburide can be decreased when it is combined with Nafcillin.
GranisetronThe serum concentration of Granisetron can be decreased when it is combined with Nafcillin.
GrepafloxacinThe serum concentration of Grepafloxacin can be decreased when it is combined with Nafcillin.
GuanfacineThe serum concentration of Guanfacine can be decreased when it is combined with Nafcillin.
HalofantrineThe serum concentration of Halofantrine can be decreased when it is combined with Nafcillin.
HaloperidolThe serum concentration of Haloperidol can be decreased when it is combined with Nafcillin.
HalothaneThe serum concentration of Halothane can be decreased when it is combined with Nafcillin.
HexobarbitalThe serum concentration of Hexobarbital can be decreased when it is combined with Nafcillin.
Histamine PhosphateThe serum concentration of Histamine Phosphate can be decreased when it is combined with Nafcillin.
HydrocodoneThe serum concentration of Hydrocodone can be decreased when it is combined with Nafcillin.
HydrocortisoneThe serum concentration of Hydrocortisone can be decreased when it is combined with Nafcillin.
HydromorphoneThe serum concentration of Hydromorphone can be decreased when it is combined with Nafcillin.
Hydroxyprogesterone caproateThe serum concentration of Hydroxyprogesterone caproate can be decreased when it is combined with Nafcillin.
Hygromycin BThe serum concentration of Hygromycin B can be decreased when it is combined with Nafcillin.
IbrutinibThe serum concentration of Ibrutinib can be decreased when it is combined with Nafcillin.
IdarubicinThe serum concentration of Idarubicin can be decreased when it is combined with Nafcillin.
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Nafcillin resulting in a loss in efficacy.
IloperidoneThe serum concentration of Iloperidone can be decreased when it is combined with Nafcillin.
ImatinibThe serum concentration of Imatinib can be decreased when it is combined with Nafcillin.
ImipramineThe serum concentration of Imipramine can be decreased when it is combined with Nafcillin.
ImiquimodThe serum concentration of Imiquimod can be decreased when it is combined with Nafcillin.
IndacaterolThe serum concentration of Indacaterol can be decreased when it is combined with Nafcillin.
IndapamideThe serum concentration of Indapamide can be decreased when it is combined with Nafcillin.
IndinavirThe serum concentration of Indinavir can be decreased when it is combined with Nafcillin.
Ipratropium bromideThe serum concentration of Ipratropium bromide can be decreased when it is combined with Nafcillin.
IrinotecanThe serum concentration of Irinotecan can be decreased when it is combined with Nafcillin.
IsavuconazoniumThe serum concentration of Isavuconazonium can be decreased when it is combined with Nafcillin.
Isosorbide DinitrateThe serum concentration of Isosorbide Dinitrate can be decreased when it is combined with Nafcillin.
Isosorbide MononitrateThe serum concentration of Isosorbide Mononitrate can be decreased when it is combined with Nafcillin.
IsradipineThe serum concentration of Isradipine can be decreased when it is combined with Nafcillin.
ItraconazoleThe serum concentration of Itraconazole can be decreased when it is combined with Nafcillin.
IvabradineThe serum concentration of Ivabradine can be decreased when it is combined with Nafcillin.
IvacaftorThe serum concentration of Ivacaftor can be decreased when it is combined with Nafcillin.
IvermectinThe serum concentration of Ivermectin can be decreased when it is combined with Nafcillin.
IxabepiloneThe serum concentration of Ixabepilone can be decreased when it is combined with Nafcillin.
IxazomibThe serum concentration of Ixazomib can be decreased when it is combined with Nafcillin.
KanamycinThe serum concentration of Kanamycin can be decreased when it is combined with Nafcillin.
KetamineThe serum concentration of Ketamine can be decreased when it is combined with Nafcillin.
KetazolamThe serum concentration of Ketazolam can be decreased when it is combined with Nafcillin.
KetobemidoneThe serum concentration of Ketobemidone can be decreased when it is combined with Nafcillin.
KetoconazoleThe serum concentration of Ketoconazole can be decreased when it is combined with Nafcillin.
LacidipineThe metabolism of Lacidipine can be increased when combined with Nafcillin.
LamotrigineThe metabolism of Lamotrigine can be increased when combined with Nafcillin.
LansoprazoleThe serum concentration of Lansoprazole can be decreased when it is combined with Nafcillin.
LapatinibThe serum concentration of Lapatinib can be decreased when it is combined with Nafcillin.
LaquinimodThe serum concentration of Laquinimod can be decreased when it is combined with Nafcillin.
LenvatinibThe serum concentration of Lenvatinib can be decreased when it is combined with Nafcillin.
LercanidipineThe serum concentration of Lercanidipine can be decreased when it is combined with Nafcillin.
LetrozoleThe serum concentration of Letrozole can be decreased when it is combined with Nafcillin.
LevobupivacaineThe serum concentration of Levobupivacaine can be decreased when it is combined with Nafcillin.
LevocetirizineThe serum concentration of Levocetirizine can be decreased when it is combined with Nafcillin.
Levomethadyl AcetateThe serum concentration of Levomethadyl Acetate can be decreased when it is combined with Nafcillin.
LevomilnacipranThe serum concentration of Levomilnacipran can be decreased when it is combined with Nafcillin.
LevonorgestrelThe serum concentration of Levonorgestrel can be decreased when it is combined with Nafcillin.
LevothyroxineThe serum concentration of Levothyroxine can be decreased when it is combined with Nafcillin.
LidocaineThe serum concentration of Lidocaine can be decreased when it is combined with Nafcillin.
LisurideThe serum concentration of Lisuride can be decreased when it is combined with Nafcillin.
LomitapideThe serum concentration of Lomitapide can be decreased when it is combined with Nafcillin.
LoperamideThe serum concentration of Loperamide can be decreased when it is combined with Nafcillin.
LopinavirThe serum concentration of Lopinavir can be decreased when it is combined with Nafcillin.
LoratadineThe serum concentration of Loratadine can be decreased when it is combined with Nafcillin.
LorcaserinThe serum concentration of Lorcaserin can be decreased when it is combined with Nafcillin.
LosartanThe serum concentration of Losartan can be decreased when it is combined with Nafcillin.
LovastatinThe serum concentration of Lovastatin can be decreased when it is combined with Nafcillin.
LumefantrineThe serum concentration of Lumefantrine can be decreased when it is combined with Nafcillin.
LurasidoneThe serum concentration of Lurasidone can be decreased when it is combined with Nafcillin.
MacitentanThe serum concentration of Macitentan can be decreased when it is combined with Nafcillin.
Magnesium SulfateThe metabolism of Magnesium Sulfate can be increased when combined with Nafcillin.
ManidipineThe metabolism of Manidipine can be increased when combined with Nafcillin.
MaravirocThe serum concentration of Maraviroc can be decreased when it is combined with Nafcillin.
MebendazoleThe serum concentration of Mebendazole can be decreased when it is combined with Nafcillin.
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Nafcillin.
MefloquineThe serum concentration of Mefloquine can be decreased when it is combined with Nafcillin.
MeloxicamThe serum concentration of Meloxicam can be decreased when it is combined with Nafcillin.
MethadoneThe serum concentration of Methadone can be decreased when it is combined with Nafcillin.
MethaqualoneThe serum concentration of Methaqualone can be decreased when it is combined with Nafcillin.
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Nafcillin.
MethoxsalenThe serum concentration of Methoxsalen can be decreased when it is combined with Nafcillin.
MethoxyfluraneThe serum concentration of Methoxyflurane can be decreased when it is combined with Nafcillin.
MethylprednisoloneThe serum concentration of Methylprednisolone can be decreased when it is combined with Nafcillin.
MethyltestosteroneThe serum concentration of Methyltestosterone can be decreased when it is combined with Nafcillin.
MetrizamideThe serum concentration of Metrizamide can be decreased when it is combined with Nafcillin.
MetronidazoleThe serum concentration of Metronidazole can be decreased when it is combined with Nafcillin.
MexiletineThe serum concentration of Mexiletine can be decreased when it is combined with Nafcillin.
MianserinThe serum concentration of Mianserin can be decreased when it is combined with Nafcillin.
MibefradilThe serum concentration of Mibefradil can be decreased when it is combined with Nafcillin.
MiconazoleThe serum concentration of Miconazole can be decreased when it is combined with Nafcillin.
MidazolamThe serum concentration of Midazolam can be decreased when it is combined with Nafcillin.
MifepristoneThe serum concentration of Mifepristone can be decreased when it is combined with Nafcillin.
MirabegronThe serum concentration of Mirabegron can be decreased when it is combined with Nafcillin.
MirtazapineThe serum concentration of Mirtazapine can be decreased when it is combined with Nafcillin.
ModafinilThe serum concentration of Modafinil can be decreased when it is combined with Nafcillin.
MontelukastThe serum concentration of Montelukast can be decreased when it is combined with Nafcillin.
MorphineThe serum concentration of Morphine can be decreased when it is combined with Nafcillin.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be decreased when it is combined with Nafcillin.
Mycophenolic acidThe serum concentration of the active metabolites of Mycophenolic acid can be reduced when Mycophenolic acid is used in combination with Nafcillin resulting in a loss in efficacy.
NaloxegolThe serum concentration of Naloxegol can be decreased when it is combined with Nafcillin.
NaloxoneThe serum concentration of Naloxone can be decreased when it is combined with Nafcillin.
NateglinideThe serum concentration of Nateglinide can be decreased when it is combined with Nafcillin.
NefazodoneThe serum concentration of Nefazodone can be decreased when it is combined with Nafcillin.
NelfinavirThe serum concentration of Nelfinavir can be decreased when it is combined with Nafcillin.
NeomycinThe serum concentration of Neomycin can be decreased when it is combined with Nafcillin.
NetilmicinThe serum concentration of Netilmicin can be decreased when it is combined with Nafcillin.
NevirapineThe serum concentration of Nevirapine can be decreased when it is combined with Nafcillin.
NicardipineThe serum concentration of Nicardipine can be decreased when it is combined with Nafcillin.
NicotineThe serum concentration of Nicotine can be decreased when it is combined with Nafcillin.
NifedipineThe serum concentration of Nifedipine can be decreased when it is combined with Nafcillin.
NiguldipineThe metabolism of Niguldipine can be increased when combined with Nafcillin.
NilotinibThe serum concentration of Nilotinib can be decreased when it is combined with Nafcillin.
NiludipineThe metabolism of Niludipine can be increased when combined with Nafcillin.
NilvadipineThe serum concentration of Nilvadipine can be decreased when it is combined with Nafcillin.
NimesulideThe metabolism of Nimesulide can be increased when combined with Nafcillin.
NimodipineThe serum concentration of Nimodipine can be decreased when it is combined with Nafcillin.
NintedanibThe serum concentration of Nintedanib can be decreased when it is combined with Nafcillin.
NisoldipineThe serum concentration of Nisoldipine can be decreased when it is combined with Nafcillin.
NitrazepamThe serum concentration of Nitrazepam can be decreased when it is combined with Nafcillin.
NitrendipineThe serum concentration of Nitrendipine can be decreased when it is combined with Nafcillin.
NorethisteroneThe serum concentration of Norethisterone can be decreased when it is combined with Nafcillin.
NorgestrelThe serum concentration of Norgestrel can be decreased when it is combined with Nafcillin.
NortriptylineThe serum concentration of Nortriptyline can be decreased when it is combined with Nafcillin.
OlaparibThe serum concentration of Olaparib can be decreased when it is combined with Nafcillin.
OlopatadineThe serum concentration of Olopatadine can be decreased when it is combined with Nafcillin.
OmeprazoleThe serum concentration of Omeprazole can be decreased when it is combined with Nafcillin.
OndansetronThe serum concentration of Ondansetron can be decreased when it is combined with Nafcillin.
OrphenadrineThe serum concentration of Orphenadrine can be decreased when it is combined with Nafcillin.
OspemifeneThe serum concentration of Ospemifene can be decreased when it is combined with Nafcillin.
OxazepamThe serum concentration of Oxazepam can be decreased when it is combined with Nafcillin.
OxybutyninThe serum concentration of Oxybutynin can be decreased when it is combined with Nafcillin.
OxycodoneThe serum concentration of Oxycodone can be decreased when it is combined with Nafcillin.
OxymorphoneThe serum concentration of Oxymorphone can be decreased when it is combined with Nafcillin.
PaclitaxelThe serum concentration of Paclitaxel can be decreased when it is combined with Nafcillin.
PalbociclibThe serum concentration of Palbociclib can be decreased when it is combined with Nafcillin.
PalonosetronThe serum concentration of Palonosetron can be decreased when it is combined with Nafcillin.
PanobinostatThe serum concentration of Panobinostat can be decreased when it is combined with Nafcillin.
PantoprazoleThe serum concentration of Pantoprazole can be decreased when it is combined with Nafcillin.
ParamethadioneThe serum concentration of Paramethadione can be decreased when it is combined with Nafcillin.
ParamethasoneThe serum concentration of Paramethasone can be decreased when it is combined with Nafcillin.
ParecoxibThe serum concentration of Parecoxib can be decreased when it is combined with Nafcillin.
ParicalcitolThe serum concentration of Paricalcitol can be decreased when it is combined with Nafcillin.
ParitaprevirThe serum concentration of Paritaprevir can be decreased when it is combined with Nafcillin.
ParomomycinThe serum concentration of Paromomycin can be decreased when it is combined with Nafcillin.
PazopanibThe serum concentration of Pazopanib can be decreased when it is combined with Nafcillin.
PentamidineThe serum concentration of Pentamidine can be decreased when it is combined with Nafcillin.
PerampanelThe serum concentration of Perampanel can be decreased when it is combined with Nafcillin.
PergolideThe serum concentration of Pergolide can be decreased when it is combined with Nafcillin.
PerhexilineThe serum concentration of Perhexiline can be decreased when it is combined with Nafcillin.
PermethrinThe serum concentration of Permethrin can be decreased when it is combined with Nafcillin.
PerphenazineThe serum concentration of Perphenazine can be decreased when it is combined with Nafcillin.
PethidineThe serum concentration of Pethidine can be decreased when it is combined with Nafcillin.
PhenacetinThe serum concentration of Phenacetin can be decreased when it is combined with Nafcillin.
PhenindioneNafcillin may increase the anticoagulant activities of Phenindione.
PhenoxybenzamineThe serum concentration of Phenoxybenzamine can be decreased when it is combined with Nafcillin.
PhenprocoumonNafcillin may increase the anticoagulant activities of Phenprocoumon.
PhenytoinThe serum concentration of Phenytoin can be decreased when it is combined with Nafcillin.
Picosulfuric acidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Nafcillin.
PilocarpineThe serum concentration of Pilocarpine can be decreased when it is combined with Nafcillin.
PimecrolimusThe serum concentration of Pimecrolimus can be decreased when it is combined with Nafcillin.
PimozideThe serum concentration of Pimozide can be decreased when it is combined with Nafcillin.
PinacidilThe serum concentration of Pinacidil can be decreased when it is combined with Nafcillin.
PinaveriumThe metabolism of Pinaverium can be increased when combined with Nafcillin.
PioglitazoneThe serum concentration of Pioglitazone can be decreased when it is combined with Nafcillin.
PipotiazineThe serum concentration of Pipotiazine can be decreased when it is combined with Nafcillin.
PlicamycinThe serum concentration of Plicamycin can be decreased when it is combined with Nafcillin.
PodofiloxThe serum concentration of Podofilox can be decreased when it is combined with Nafcillin.
PomalidomideThe serum concentration of Pomalidomide can be decreased when it is combined with Nafcillin.
PonatinibThe serum concentration of Ponatinib can be decreased when it is combined with Nafcillin.
PosaconazoleThe serum concentration of Posaconazole can be decreased when it is combined with Nafcillin.
PrasugrelThe serum concentration of Prasugrel can be decreased when it is combined with Nafcillin.
PravastatinThe serum concentration of Pravastatin can be decreased when it is combined with Nafcillin.
PrazepamThe serum concentration of Prazepam can be decreased when it is combined with Nafcillin.
PraziquantelThe serum concentration of Praziquantel can be decreased when it is combined with Nafcillin.
PrednisoloneThe serum concentration of Prednisolone can be decreased when it is combined with Nafcillin.
PrednisoneThe serum concentration of Prednisone can be decreased when it is combined with Nafcillin.
PregabalinThe metabolism of Pregabalin can be increased when combined with Nafcillin.
PrenylamineThe metabolism of Prenylamine can be increased when combined with Nafcillin.
PrimaquineThe serum concentration of Primaquine can be decreased when it is combined with Nafcillin.
ProbenecidThe serum concentration of Nafcillin can be increased when it is combined with Probenecid.
ProchlorperazineThe serum concentration of Prochlorperazine can be decreased when it is combined with Nafcillin.
ProgesteroneThe serum concentration of Progesterone can be decreased when it is combined with Nafcillin.
ProguanilThe serum concentration of Proguanil can be decreased when it is combined with Nafcillin.
PromazineThe serum concentration of Promazine can be decreased when it is combined with Nafcillin.
PropafenoneThe serum concentration of Propafenone can be decreased when it is combined with Nafcillin.
PropofolThe serum concentration of Propofol can be decreased when it is combined with Nafcillin.
PropranololThe serum concentration of Propranolol can be decreased when it is combined with Nafcillin.
PuromycinThe serum concentration of Puromycin can be decreased when it is combined with Nafcillin.
PyrazinamideThe serum concentration of Pyrazinamide can be decreased when it is combined with Nafcillin.
QuazepamThe serum concentration of Quazepam can be decreased when it is combined with Nafcillin.
QuetiapineThe serum concentration of Quetiapine can be decreased when it is combined with Nafcillin.
QuinacrineThe serum concentration of Quinacrine can be decreased when it is combined with Nafcillin.
QuinidineThe serum concentration of Quinidine can be decreased when it is combined with Nafcillin.
QuinineThe serum concentration of Quinine can be decreased when it is combined with Nafcillin.
RabeprazoleThe serum concentration of Rabeprazole can be decreased when it is combined with Nafcillin.
RaloxifeneThe serum concentration of Raloxifene can be decreased when it is combined with Nafcillin.
RamelteonThe serum concentration of Ramelteon can be decreased when it is combined with Nafcillin.
RanolazineThe serum concentration of Ranolazine can be decreased when it is combined with Nafcillin.
ReboxetineThe serum concentration of Reboxetine can be decreased when it is combined with Nafcillin.
RegorafenibThe serum concentration of Regorafenib can be decreased when it is combined with Nafcillin.
RepaglinideThe serum concentration of Repaglinide can be decreased when it is combined with Nafcillin.
RetapamulinThe serum concentration of Retapamulin can be decreased when it is combined with Nafcillin.
RibostamycinThe serum concentration of Ribostamycin can be decreased when it is combined with Nafcillin.
RifabutinThe serum concentration of Rifabutin can be decreased when it is combined with Nafcillin.
RifampicinThe serum concentration of Rifampicin can be decreased when it is combined with Nafcillin.
RilpivirineThe serum concentration of Rilpivirine can be decreased when it is combined with Nafcillin.
RimonabantThe serum concentration of Rimonabant can be decreased when it is combined with Nafcillin.
RiociguatThe serum concentration of Riociguat can be decreased when it is combined with Nafcillin.
RisedronateThe metabolism of Risedronate can be increased when combined with Nafcillin.
RisperidoneThe serum concentration of Risperidone can be decreased when it is combined with Nafcillin.
RitonavirThe serum concentration of Ritonavir can be decreased when it is combined with Nafcillin.
RivaroxabanThe serum concentration of Rivaroxaban can be decreased when it is combined with Nafcillin.
RofecoxibThe serum concentration of Rofecoxib can be decreased when it is combined with Nafcillin.
RolapitantThe serum concentration of Rolapitant can be decreased when it is combined with Nafcillin.
RomidepsinThe serum concentration of Romidepsin can be decreased when it is combined with Nafcillin.
RopiniroleThe serum concentration of Ropinirole can be decreased when it is combined with Nafcillin.
RopivacaineThe serum concentration of Ropivacaine can be decreased when it is combined with Nafcillin.
RosuvastatinThe serum concentration of Rosuvastatin can be decreased when it is combined with Nafcillin.
RotigotineThe serum concentration of Rotigotine can be decreased when it is combined with Nafcillin.
RoxithromycinThe serum concentration of Roxithromycin can be decreased when it is combined with Nafcillin.
RuxolitinibThe serum concentration of Ruxolitinib can be decreased when it is combined with Nafcillin.
SalmeterolThe serum concentration of Salmeterol can be decreased when it is combined with Nafcillin.
SaquinavirThe serum concentration of Saquinavir can be decreased when it is combined with Nafcillin.
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Nafcillin.
SelegilineThe serum concentration of Selegiline can be decreased when it is combined with Nafcillin.
SelexipagThe serum concentration of Selexipag can be decreased when it is combined with Nafcillin.
SeratrodastThe serum concentration of Seratrodast can be decreased when it is combined with Nafcillin.
SertindoleThe serum concentration of Sertindole can be decreased when it is combined with Nafcillin.
SertralineThe serum concentration of Sertraline can be decreased when it is combined with Nafcillin.
SevofluraneThe serum concentration of Sevoflurane can be decreased when it is combined with Nafcillin.
SibutramineThe serum concentration of Sibutramine can be decreased when it is combined with Nafcillin.
SildenafilThe serum concentration of Sildenafil can be decreased when it is combined with Nafcillin.
SilodosinThe serum concentration of Silodosin can be decreased when it is combined with Nafcillin.
SimeprevirThe serum concentration of Simeprevir can be decreased when it is combined with Nafcillin.
SimvastatinThe serum concentration of Simvastatin can be decreased when it is combined with Nafcillin.
SirolimusThe serum concentration of Sirolimus can be decreased when it is combined with Nafcillin.
SitagliptinThe serum concentration of Sitagliptin can be decreased when it is combined with Nafcillin.
SolifenacinThe serum concentration of Solifenacin can be decreased when it is combined with Nafcillin.
SonidegibThe serum concentration of Sonidegib can be decreased when it is combined with Nafcillin.
SorafenibThe serum concentration of Sorafenib can be decreased when it is combined with Nafcillin.
SpectinomycinThe serum concentration of Spectinomycin can be decreased when it is combined with Nafcillin.
SpiramycinThe serum concentration of Spiramycin can be decreased when it is combined with Nafcillin.
StreptomycinThe serum concentration of Streptomycin can be decreased when it is combined with Nafcillin.
StreptozocinThe serum concentration of Streptozocin can be decreased when it is combined with Nafcillin.
SufentanilThe serum concentration of Sufentanil can be decreased when it is combined with Nafcillin.
SulfadiazineThe serum concentration of Sulfadiazine can be decreased when it is combined with Nafcillin.
SulfamethoxazoleThe serum concentration of Sulfamethoxazole can be decreased when it is combined with Nafcillin.
SulfinpyrazoneThe serum concentration of Sulfinpyrazone can be decreased when it is combined with Nafcillin.
SunitinibThe serum concentration of Sunitinib can be decreased when it is combined with Nafcillin.
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be decreased when it is combined with Nafcillin.
Synthetic Conjugated Estrogens, BThe serum concentration of Synthetic Conjugated Estrogens, B can be decreased when it is combined with Nafcillin.
TacrolimusThe serum concentration of Tacrolimus can be decreased when it is combined with Nafcillin.
TadalafilThe serum concentration of Tadalafil can be decreased when it is combined with Nafcillin.
TamoxifenThe serum concentration of Tamoxifen can be decreased when it is combined with Nafcillin.
TamsulosinThe serum concentration of Tamsulosin can be decreased when it is combined with Nafcillin.
TasosartanThe serum concentration of Tasosartan can be decreased when it is combined with Nafcillin.
Taurochenodeoxycholic acidThe serum concentration of Taurochenodeoxycholic acid can be decreased when it is combined with Nafcillin.
TelaprevirThe serum concentration of Telaprevir can be decreased when it is combined with Nafcillin.
TelithromycinThe serum concentration of Telithromycin can be decreased when it is combined with Nafcillin.
TemazepamThe serum concentration of Temazepam can be decreased when it is combined with Nafcillin.
TemsirolimusThe serum concentration of Temsirolimus can be decreased when it is combined with Nafcillin.
TeniposideThe serum concentration of Teniposide can be decreased when it is combined with Nafcillin.
TerbinafineThe serum concentration of Terbinafine can be decreased when it is combined with Nafcillin.
TerfenadineThe serum concentration of Terfenadine can be decreased when it is combined with Nafcillin.
TesmilifeneThe serum concentration of Tesmilifene can be decreased when it is combined with Nafcillin.
TestosteroneThe serum concentration of Testosterone can be decreased when it is combined with Nafcillin.
TetracyclineThe serum concentration of Tetracycline can be decreased when it is combined with Nafcillin.
TheophyllineThe serum concentration of Theophylline can be decreased when it is combined with Nafcillin.
ThiotepaThe serum concentration of Thiotepa can be decreased when it is combined with Nafcillin.
TiagabineThe serum concentration of Tiagabine can be decreased when it is combined with Nafcillin.
TicagrelorThe serum concentration of Ticagrelor can be decreased when it is combined with Nafcillin.
TiclopidineThe serum concentration of Ticlopidine can be decreased when it is combined with Nafcillin.
TinidazoleThe serum concentration of Tinidazole can be decreased when it is combined with Nafcillin.
TiotropiumThe serum concentration of Tiotropium can be decreased when it is combined with Nafcillin.
TipranavirThe serum concentration of Tipranavir can be decreased when it is combined with Nafcillin.
TobramycinThe serum concentration of Tobramycin can be decreased when it is combined with Nafcillin.
TofacitinibThe serum concentration of Tofacitinib can be decreased when it is combined with Nafcillin.
Tolfenamic AcidThe metabolism of Tolfenamic Acid can be increased when combined with Nafcillin.
TolterodineThe serum concentration of Tolterodine can be decreased when it is combined with Nafcillin.
TolvaptanThe serum concentration of Tolvaptan can be decreased when it is combined with Nafcillin.
ToremifeneThe serum concentration of Toremifene can be decreased when it is combined with Nafcillin.
TrabectedinThe serum concentration of Trabectedin can be decreased when it is combined with Nafcillin.
TramadolThe serum concentration of Tramadol can be decreased when it is combined with Nafcillin.
TranilastThe metabolism of Tranilast can be increased when combined with Nafcillin.
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be decreased when it is combined with Nafcillin.
TrazodoneThe serum concentration of Trazodone can be decreased when it is combined with Nafcillin.
TretinoinThe serum concentration of Tretinoin can be decreased when it is combined with Nafcillin.
TriamcinoloneThe serum concentration of Triamcinolone can be decreased when it is combined with Nafcillin.
TriazolamThe serum concentration of Triazolam can be decreased when it is combined with Nafcillin.
TrimethadioneThe serum concentration of Trimethadione can be decreased when it is combined with Nafcillin.
TrimethoprimThe serum concentration of Trimethoprim can be decreased when it is combined with Nafcillin.
TrimipramineThe serum concentration of Trimipramine can be decreased when it is combined with Nafcillin.
TroglitazoneThe serum concentration of Troglitazone can be decreased when it is combined with Nafcillin.
TroleandomycinThe serum concentration of Troleandomycin can be decreased when it is combined with Nafcillin.
UdenafilThe serum concentration of Udenafil can be decreased when it is combined with Nafcillin.
UlipristalThe serum concentration of Ulipristal can be decreased when it is combined with Nafcillin.
ValdecoxibThe serum concentration of Valdecoxib can be decreased when it is combined with Nafcillin.
VandetanibThe serum concentration of Vandetanib can be decreased when it is combined with Nafcillin.
VanoxerineThe serum concentration of Vanoxerine can be decreased when it is combined with Nafcillin.
VardenafilThe serum concentration of Vardenafil can be decreased when it is combined with Nafcillin.
VemurafenibThe serum concentration of Vemurafenib can be decreased when it is combined with Nafcillin.
VenlafaxineThe serum concentration of Venlafaxine can be decreased when it is combined with Nafcillin.
VerapamilThe serum concentration of Verapamil can be decreased when it is combined with Nafcillin.
VicrivirocThe serum concentration of Vicriviroc can be decreased when it is combined with Nafcillin.
VilanterolThe serum concentration of Vilanterol can be decreased when it is combined with Nafcillin.
VilazodoneThe serum concentration of Vilazodone can be decreased when it is combined with Nafcillin.
VinblastineThe serum concentration of Vinblastine can be decreased when it is combined with Nafcillin.
VincristineThe serum concentration of Vincristine can be decreased when it is combined with Nafcillin.
VindesineThe serum concentration of Vindesine can be decreased when it is combined with Nafcillin.
VinorelbineThe serum concentration of Vinorelbine can be decreased when it is combined with Nafcillin.
VismodegibThe serum concentration of Vismodegib can be decreased when it is combined with Nafcillin.
VoriconazoleThe serum concentration of Voriconazole can be decreased when it is combined with Nafcillin.
VortioxetineThe serum concentration of Vortioxetine can be decreased when it is combined with Nafcillin.
WarfarinNafcillin may increase the anticoagulant activities of Warfarin.
XylometazolineThe metabolism of Xylometazoline can be increased when combined with Nafcillin.
YohimbineThe serum concentration of Yohimbine can be decreased when it is combined with Nafcillin.
ZafirlukastThe serum concentration of Zafirlukast can be decreased when it is combined with Nafcillin.
ZalcitabineThe serum concentration of Zalcitabine can be decreased when it is combined with Nafcillin.
ZaleplonThe serum concentration of Zaleplon can be decreased when it is combined with Nafcillin.
ZiconotideThe metabolism of Ziconotide can be increased when combined with Nafcillin.
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Nafcillin.
ZileutonThe serum concentration of Zileuton can be decreased when it is combined with Nafcillin.
ZiprasidoneThe serum concentration of Ziprasidone can be decreased when it is combined with Nafcillin.
ZolpidemThe serum concentration of Zolpidem can be decreased when it is combined with Nafcillin.
ZomepiracThe serum concentration of Zomepirac can be decreased when it is combined with Nafcillin.
ZonisamideThe serum concentration of Zonisamide can be decreased when it is combined with Nafcillin.
ZopicloneThe serum concentration of Zopiclone can be decreased when it is combined with Nafcillin.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Pharmacological action
yes
Actions
inhibitor
General Function:
Transferase activity, transferring acyl groups
Specific Function:
Not Available
Gene Name:
pbp1b
Uniprot ID:
Q7CRA4
Molecular Weight:
89479.92 Da
References
  1. Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. [PubMed:7447421 ]
Kind
Protein
Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Pharmacological action
yes
Actions
inhibitor
General Function:
Penicillin binding
Specific Function:
Not Available
Gene Name:
penA
Uniprot ID:
P0A3M6
Molecular Weight:
73872.305 Da
References
  1. Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. [PubMed:7447421 ]
Kind
Protein
Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Pharmacological action
yes
Actions
inhibitor
General Function:
Transferase activity, transferring acyl groups
Specific Function:
Not Available
Gene Name:
pbp2a
Uniprot ID:
Q8DNB6
Molecular Weight:
80797.94 Da
References
  1. Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. [PubMed:7447421 ]
Kind
Protein
Organism
Streptococcus pneumoniae
Pharmacological action
yes
Actions
inhibitor
General Function:
Serine-type d-ala-d-ala carboxypeptidase activity
Specific Function:
Not Available
Gene Name:
pbp3
Uniprot ID:
Q75Y35
Molecular Weight:
45209.84 Da
References
  1. Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. [PubMed:7447421 ]
Kind
Protein
Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Pharmacological action
yes
Actions
inhibitor
General Function:
Penicillin binding
Specific Function:
Cell wall formation.
Gene Name:
pbpA
Uniprot ID:
Q8DR59
Molecular Weight:
79700.9 Da
References
  1. Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. [PubMed:7447421 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Yasuda K, Ranade A, Venkataramanan R, Strom S, Chupka J, Ekins S, Schuetz E, Bachmann K: A comprehensive in vitro and in silico analysis of antibiotics that activate pregnane X receptor and induce CYP3A4 in liver and intestine. Drug Metab Dispos. 2008 Aug;36(8):1689-97. doi: 10.1124/dmd.108.020701. Epub 2008 May 27. [PubMed:18505790 ]
  2. Kim KY, Frey RJ, Epplen K, Foruhari F: Interaction between warfarin and nafcillin: case report and review of the literature. Pharmacotherapy. 2007 Oct;27(10):1467-70. [PubMed:17896903 ]
  3. Lang CC, Jamal SK, Mohamed Z, Mustafa MR, Mustafa AM, Lee TC: Evidence of an interaction between nifedipine and nafcillin in humans. Br J Clin Pharmacol. 2003 Jun;55(6):588-90. [PubMed:12814453 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-in...
Gene Name:
SLC22A6
Uniprot ID:
Q4U2R8
Molecular Weight:
61815.78 Da
References
  1. Jariyawat S, Sekine T, Takeda M, Apiwattanakul N, Kanai Y, Sophasan S, Endou H: The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1. J Pharmacol Exp Ther. 1999 Aug;290(2):672-7. [PubMed:10411577 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23