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Identification
NameSimvastatin
Accession NumberDB00641  (APRD00104)
TypeSmall Molecule
GroupsApproved
DescriptionSimvastatin is a lipid-lowering agent that is derived synthetically from the fermentation of Aspergillus terreus. It is a potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (hydroxymethylglutaryl COA reductases), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL receptors, it increases breakdown of LDL cholesterol. [PubChem]
Structure
Thumb
Synonyms
2,2-Dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8ar)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one
MK-733
Simvastatin
Simvastatina
Simvastatine
Simvastatinum
Synvinolin
Zocor
External Identifiers
  • MK 733
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Act Simvastatintablet20 mgoralActavis Pharma Company2003-09-26Not applicableCanada
Act Simvastatintablet40 mgoralActavis Pharma Company2003-09-26Not applicableCanada
Act Simvastatintablet80 mgoralActavis Pharma Company2003-09-26Not applicableCanada
Act Simvastatintablet5 mgoralActavis Pharma Company2003-09-26Not applicableCanada
Act Simvastatintablet10 mgoralActavis Pharma Company2003-09-26Not applicableCanada
Auro-simvastatintablet80 mgoralAuro Pharma Inc2013-07-08Not applicableCanada
Auro-simvastatintablet40 mgoralAuro Pharma Inc2013-07-08Not applicableCanada
Auro-simvastatintablet10 mgoralAuro Pharma Inc2013-07-08Not applicableCanada
Auro-simvastatintablet20 mgoralAuro Pharma Inc2013-07-08Not applicableCanada
Auro-simvastatintablet5 mgoralAuro Pharma Inc2013-07-08Not applicableCanada
Ava-simvastatintablet5 mgoralAvanstra Inc2011-10-112014-08-21Canada
Ava-simvastatintablet80 mgoralAvanstra Inc2011-10-112014-08-21Canada
Ava-simvastatintablet10 mgoralAvanstra Inc2011-10-112014-08-21Canada
Ava-simvastatintablet20 mgoralAvanstra Inc2011-10-112014-08-21Canada
Ava-simvastatintablet40 mgoralAvanstra Inc2011-10-112014-08-21Canada
Bci Simvastatintablet10 mgoralBaker Cummins IncNot applicableNot applicableCanada
Bci Simvastatintablet20 mgoralBaker Cummins IncNot applicableNot applicableCanada
Bci Simvastatintablet40 mgoralBaker Cummins IncNot applicableNot applicableCanada
Bci Simvastatintablet5 mgoralBaker Cummins IncNot applicableNot applicableCanada
Bci Simvastatintablet80 mgoralBaker Cummins IncNot applicableNot applicableCanada
Dom-simvastatintablet80 mgoralDominion Pharmacal2004-08-11Not applicableCanada
Dom-simvastatintablet80 mgoralDominion Pharmacal2006-08-02Not applicableCanada
Dom-simvastatintablet10 mgoralDominion Pharmacal2004-08-11Not applicableCanada
Dom-simvastatintablet10 mgoralDominion Pharmacal2006-08-02Not applicableCanada
Dom-simvastatintablet20 mgoralDominion Pharmacal2004-08-11Not applicableCanada
Dom-simvastatintablet20 mgoralDominion Pharmacal2006-08-02Not applicableCanada
Dom-simvastatintablet40 mgoralDominion Pharmacal2004-08-11Not applicableCanada
Dom-simvastatintablet40 mgoralDominion Pharmacal2006-08-02Not applicableCanada
Dom-simvastatintablet5 mgoralDominion Pharmacal2004-08-11Not applicableCanada
Dom-simvastatintablet5 mgoralDominion Pharmacal2006-08-02Not applicableCanada
Ipg-simvastatintablet40 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-simvastatintablet80 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-simvastatintablet5 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-simvastatintablet10 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-simvastatintablet20 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Jamp-simvastatintablet40 mgoralJamp Pharma Corporation2012-01-09Not applicableCanada
Jamp-simvastatintablet20 mgoralJamp Pharma Corporation2010-03-122013-07-08Canada
Jamp-simvastatintablet5 mgoralJamp Pharma Corporation2012-01-09Not applicableCanada
Jamp-simvastatintablet80 mgoralJamp Pharma Corporation2012-01-09Not applicableCanada
Jamp-simvastatintablet40 mgoralJamp Pharma Corporation2010-03-122013-07-08Canada
Jamp-simvastatintablet10 mgoralJamp Pharma Corporation2012-01-09Not applicableCanada
Jamp-simvastatintablet5 mgoralJamp Pharma Corporation2010-03-232013-07-08Canada
Jamp-simvastatintablet80 mgoralJamp Pharma Corporation2010-03-122013-07-08Canada
Jamp-simvastatintablet20 mgoralJamp Pharma Corporation2012-01-09Not applicableCanada
Jamp-simvastatintablet10 mgoralJamp Pharma Corporation2010-03-122013-07-08Canada
Mar-simvastatintablet80 mgoralMarcan Pharmaceuticals Inc2012-12-20Not applicableCanada
Mar-simvastatintablet10 mgoralMarcan Pharmaceuticals Inc2012-12-20Not applicableCanada
Mar-simvastatintablet20 mgoralMarcan Pharmaceuticals Inc2012-12-20Not applicableCanada
Mar-simvastatintablet40 mgoralMarcan Pharmaceuticals Inc2012-12-20Not applicableCanada
Mar-simvastatintablet5 mgoralMarcan Pharmaceuticals Inc2012-12-20Not applicableCanada
Mint-simvastatintablet20 mgoralMint Pharmaceuticals Inc2011-09-07Not applicableCanada
Mint-simvastatintablet40 mgoralMint Pharmaceuticals Inc2011-09-07Not applicableCanada
Mint-simvastatintablet80 mgoralMint Pharmaceuticals Inc2011-09-07Not applicableCanada
Mint-simvastatintablet5 mgoralMint Pharmaceuticals Inc2011-09-07Not applicableCanada
Mint-simvastatintablet10 mgoralMint Pharmaceuticals Inc2011-09-07Not applicableCanada
Mylan-simvastatintablet40 mgoralMylan Pharmaceuticals Ulc2003-01-15Not applicableCanada
Mylan-simvastatintablet80 mgoralMylan Pharmaceuticals Ulc2003-01-15Not applicableCanada
Mylan-simvastatintablet5 mgoralMylan Pharmaceuticals Ulc2003-01-15Not applicableCanada
Mylan-simvastatintablet20 mgoralMylan Pharmaceuticals Ulc2003-01-15Not applicableCanada
Mylan-simvastatintablet10 mgoralMylan Pharmaceuticals Ulc2003-01-15Not applicableCanada
Ntp-simvastatintablet5 mgoralNt Pharma Canada LtdNot applicableNot applicableCanada
Ntp-simvastatintablet80 mgoralNt Pharma Canada LtdNot applicableNot applicableCanada
Ntp-simvastatintablet10 mgoralNt Pharma Canada LtdNot applicableNot applicableCanada
Ntp-simvastatintablet20 mgoralNt Pharma Canada LtdNot applicableNot applicableCanada
Ntp-simvastatintablet40 mgoralNt Pharma Canada LtdNot applicableNot applicableCanada
Nu-simvastatin Tabletstablet10 mgoralNu Pharm Inc2004-06-212012-09-04Canada
Nu-simvastatin Tabletstablet20 mgoralNu Pharm Inc2004-06-212012-09-04Canada
Nu-simvastatin Tabletstablet40 mgoralNu Pharm Inc2004-06-212012-09-04Canada
Nu-simvastatin Tabletstablet80 mgoralNu Pharm Inc2004-06-212012-09-04Canada
Nu-simvastatin Tabletstablet5 mgoralNu Pharm Inc2004-06-212012-09-04Canada
PHL-simvastatintablet20 mgoralPharmel Inc2004-08-11Not applicableCanada
PHL-simvastatintablet20 mgoralPharmel Inc2006-07-21Not applicableCanada
PHL-simvastatintablet40 mgoralPharmel Inc2004-08-11Not applicableCanada
PHL-simvastatintablet40 mgoralPharmel Inc2006-07-21Not applicableCanada
PHL-simvastatintablet80 mgoralPharmel Inc2004-08-11Not applicableCanada
PHL-simvastatintablet80 mgoralPharmel Inc2006-07-21Not applicableCanada
PHL-simvastatintablet5 mgoralPharmel Inc2004-08-11Not applicableCanada
PHL-simvastatintablet5 mgoralPharmel Inc2006-07-21Not applicableCanada
PHL-simvastatintablet10 mgoralPharmel Inc2004-08-11Not applicableCanada
PHL-simvastatintablet10 mgoralPharmel Inc2006-07-21Not applicableCanada
PMS-simvastatintablet40 mgoralPharmascience Inc2004-05-07Not applicableCanada
PMS-simvastatintablet40 mgoralPharmascience Inc2005-11-03Not applicableCanada
PMS-simvastatintablet5 mgoralPharmascience Inc2004-05-07Not applicableCanada
PMS-simvastatintablet5 mgoralPharmascience Inc2005-11-03Not applicableCanada
PMS-simvastatintablet80 mgoralPharmascience Inc2004-05-07Not applicableCanada
PMS-simvastatintablet80 mgoralPharmascience Inc2005-11-03Not applicableCanada
PMS-simvastatintablet10 mgoralPharmascience Inc2004-05-07Not applicableCanada
PMS-simvastatintablet10 mgoralPharmascience Inc2005-11-03Not applicableCanada
PMS-simvastatintablet20 mgoralPharmascience Inc2004-05-07Not applicableCanada
PMS-simvastatintablet20 mgoralPharmascience Inc2005-11-03Not applicableCanada
Q-simvastatintablet10 mgoralQd Pharmaceuticals Ulc2012-02-032015-08-21Canada
Q-simvastatintablet20 mgoralQd Pharmaceuticals Ulc2012-02-032015-08-21Canada
Q-simvastatintablet40 mgoralQd Pharmaceuticals Ulc2012-02-032015-08-21Canada
Q-simvastatintablet5 mgoralQd Pharmaceuticals UlcNot applicableNot applicableCanada
Q-simvastatintablet80 mgoralQd Pharmaceuticals UlcNot applicableNot applicableCanada
Ran-simvastatintablet20 mgoralRanbaxy Pharmaceuticals Canada Inc.2009-07-20Not applicableCanada
Ran-simvastatintablet40 mgoralRanbaxy Pharmaceuticals Canada Inc.2009-07-20Not applicableCanada
Ran-simvastatintablet5 mgoralRanbaxy Pharmaceuticals Canada Inc.2009-07-20Not applicableCanada
Ran-simvastatintablet80 mgoralRanbaxy Pharmaceuticals Canada Inc.2009-07-20Not applicableCanada
Ran-simvastatintablet10 mgoralRanbaxy Pharmaceuticals Canada Inc.2009-07-20Not applicableCanada
Ratio-simvastatintablet20 mgoralRatiopharm Inc Division Of Teva Canada Limited2003-10-272014-09-19Canada
Ratio-simvastatintablet40 mgoralRatiopharm Inc Division Of Teva Canada Limited2003-10-272014-09-19Canada
Ratio-simvastatintablet5 mgoralRatiopharm Inc Division Of Teva Canada Limited2003-10-272014-09-19Canada
Ratio-simvastatintablet80 mgoralRatiopharm Inc Division Of Teva Canada Limited2003-10-272014-09-19Canada
Ratio-simvastatintablet10 mgoralRatiopharm Inc Division Of Teva Canada Limited2003-10-272014-09-19Canada
Riva-simvastatintablet80 mgoralLaboratoire Riva Inc2003-03-10Not applicableCanada
Riva-simvastatintablet10 mgoralLaboratoire Riva Inc2003-03-10Not applicableCanada
Riva-simvastatintablet20 mgoralLaboratoire Riva Inc2003-03-10Not applicableCanada
Riva-simvastatintablet40 mgoralLaboratoire Riva Inc2003-03-10Not applicableCanada
Riva-simvastatintablet5 mgoralLaboratoire Riva Inc2003-03-10Not applicableCanada
Sandoz Simvastatintablet40 mgoralSandoz Canada Incorporated2003-10-29Not applicableCanada
Sandoz Simvastatintablet5 mgoralSandoz Canada Incorporated2003-10-29Not applicableCanada
Sandoz Simvastatintablet80 mgoralSandoz Canada Incorporated2003-10-29Not applicableCanada
Sandoz Simvastatintablet10 mgoralSandoz Canada Incorporated2003-10-29Not applicableCanada
Sandoz Simvastatintablet20 mgoralSandoz Canada Incorporated2004-06-23Not applicableCanada
Septa-simvastatintablet10 mgoralSepta Pharmaceuticals IncNot applicableNot applicableCanada
Septa-simvastatintablet20 mgoralSepta Pharmaceuticals IncNot applicableNot applicableCanada
Septa-simvastatintablet40 mgoralSepta Pharmaceuticals IncNot applicableNot applicableCanada
Septa-simvastatintablet5 mgoralSepta Pharmaceuticals IncNot applicableNot applicableCanada
Septa-simvastatintablet80 mgoralSepta Pharmaceuticals IncNot applicableNot applicableCanada
Simvastatintablet20 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Simvastatintablet40 mgoralBentec Pharma IncNot applicableNot applicableCanada
Simvastatintablet5 mgoralFrosst A Division Of Merck Canada IncNot applicableNot applicableCanada
Simvastatintablet20 mgoralSivem Pharmaceuticals Ulc2012-06-12Not applicableCanada
Simvastatintablet40 mgoralSanis Health Inc2009-10-22Not applicableCanada
Simvastatintablet10 mgoralMeliapharm Inc2010-06-112014-06-25Canada
Simvastatintablet10 mgoralBentec Pharma Inc2013-03-012015-12-15Canada
Simvastatintablet80 mgoralFrosst A Division Of Merck Canada IncNot applicableNot applicableCanada
Simvastatintablet40 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Simvastatintablet80 mgoralBentec Pharma IncNot applicableNot applicableCanada
Simvastatintablet10 mgoralFrosst A Division Of Merck Canada IncNot applicableNot applicableCanada
Simvastatintablet5 mgoralSanis Health Inc2009-10-22Not applicableCanada
Simvastatintablet40 mgoralSivem Pharmaceuticals Ulc2012-06-11Not applicableCanada
Simvastatintablet80 mgoralSanis Health Inc2009-10-22Not applicableCanada
Simvastatintablet20 mgoralMeliapharm Inc2010-06-112014-06-25Canada
Simvastatintablet5 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Simvastatintablet5 mgoralBentec Pharma IncNot applicableNot applicableCanada
Simvastatintablet80 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Simvastatintablet20 mgoralFrosst A Division Of Merck Canada IncNot applicableNot applicableCanada
Simvastatintablet10 mgoralSanis Health Inc2009-10-22Not applicableCanada
Simvastatintablet80 mgoralSivem Pharmaceuticals Ulc2012-06-11Not applicableCanada
Simvastatintablet5 mgoralSivem Pharmaceuticals Ulc2012-06-11Not applicableCanada
Simvastatintablet40 mgoralMeliapharm Inc2010-06-112014-06-25Canada
Simvastatintablet10 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Simvastatintablet20 mgoralBentec Pharma IncNot applicableNot applicableCanada
Simvastatintablet20 mgoralSanis Health Inc2009-10-22Not applicableCanada
Simvastatintablet5 mgoralMeliapharm Inc2010-06-112014-06-25Canada
Simvastatintablet40 mgoralFrosst A Division Of Merck Canada IncNot applicableNot applicableCanada
Simvastatintablet10 mgoralSivem Pharmaceuticals Ulc2012-06-11Not applicableCanada
Simvastatintablet80 mgoralMeliapharm Inc2010-06-112014-06-25Canada
Simvastatin Tabletstablet5 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Simvastatin Tabletstablet80 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Simvastatin Tabletstablet10 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Simvastatin Tabletstablet20 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Simvastatin Tabletstablet40 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Simvastatin Tablets 10mgtablet10 mgoralPrempharm Inc2003-09-032005-08-05Canada
Simvastatin Tablets 20mgtablet20 mgoralPrempharm Inc2003-09-032005-08-05Canada
Simvastatin Tablets 40mgtablet40 mgoralPrempharm Inc2003-09-032005-08-05Canada
Simvastatin Tablets 5mgtablet5 mgoralPrempharm Inc2003-09-032005-08-05Canada
Simvastatin Tablets 80mgtablet80 mgoralPrempharm Inc2003-09-032005-08-05Canada
Simvastatin-10tablet10 mgoralPro Doc Limitee2003-04-10Not applicableCanada
Simvastatin-20tablet20 mgoralPro Doc Limitee2003-04-10Not applicableCanada
Simvastatin-40tablet40 mgoralPro Doc Limitee2003-04-10Not applicableCanada
Simvastatin-80tablet80 mgoralPro Doc Limitee2009-06-15Not applicableCanada
Simvastatin-odantablet20 mgoralOdan Laboratories Ltd2012-02-142014-11-12Canada
Simvastatin-odantablet40 mgoralOdan Laboratories Ltd2012-02-142014-11-12Canada
Simvastatin-odantablet5 mgoralOdan Laboratories Ltd2012-02-142014-11-12Canada
Simvastatin-odantablet80 mgoralOdan Laboratories Ltd2012-02-142014-11-17Canada
Simvastatin-odantablet10 mgoralOdan Laboratories Ltd2012-02-142014-11-12Canada
Taro-simvastatintablet40 mgoralTaro Pharmaceuticals Inc2005-08-102014-04-01Canada
Taro-simvastatintablet10 mgoralTaro Pharmaceuticals Inc2005-08-102014-04-01Canada
Taro-simvastatintablet20 mgoralTaro Pharmaceuticals Inc2005-08-102014-04-01Canada
Teva-simvastatintablet80 mgoralTeva Canada Limited2004-03-22Not applicableCanada
Teva-simvastatintablet10 mgoralTeva Canada Limited2004-03-22Not applicableCanada
Teva-simvastatintablet20 mgoralTeva Canada Limited2004-03-22Not applicableCanada
Teva-simvastatintablet40 mgoralTeva Canada Limited2004-03-22Not applicableCanada
Teva-simvastatintablet5 mgoralTeva Canada Limited2004-03-22Not applicableCanada
Zocortablet20 mgoralMerck Canada Inc1994-12-31Not applicableCanada
Zocortablet, film coated80 mg/1oralMerck Sharp & Dohme Corp.1991-12-23Not applicableUs
Zocortablet, film coated40 mg/1oralMerck Sharp & Dohme Corp.1991-12-23Not applicableUs
Zocortablet40 mgoralMerck Canada Inc1996-08-14Not applicableCanada
Zocortablet80 mgoralMerck Canada Inc1999-07-212014-05-06Canada
Zocortablet, film coated5 mg/1oralMerck Sharp & Dohme Corp.1991-12-23Not applicableUs
Zocortablet5 mgoralMerck Canada Inc1991-12-312016-06-08Canada
Zocortablet, film coated20 mg/1oralLake Erie Medical Surgical & Supply DBA Quality Care Products LLC2011-08-08Not applicableUs
Zocortablet, film coated10 mg/1oralMerck Sharp & Dohme Corp.1991-12-23Not applicableUs
Zocortablet10 mgoralMerck Canada Inc1990-12-31Not applicableCanada
Zocortablet, film coated20 mg/1oralMerck Sharp & Dohme Corp.1991-12-23Not applicableUs
Zym-simvastatintablet40 mgoralZymcan Pharmaceuticals Inc2009-02-262014-06-16Canada
Zym-simvastatintablet80 mgoralZymcan Pharmaceuticals Inc2009-02-262014-06-16Canada
Zym-simvastatintablet5 mgoralZymcan Pharmaceuticals Inc2009-02-262014-06-16Canada
Zym-simvastatintablet10 mgoralZymcan Pharmaceuticals Inc2009-02-262014-06-16Canada
Zym-simvastatintablet20 mgoralZymcan Pharmaceuticals Inc2009-02-262014-06-16Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-simvastatintablet20 mgoralApotex Inc2002-12-20Not applicableCanada
Apo-simvastatintablet40 mgoralApotex Inc2002-12-20Not applicableCanada
Apo-simvastatintablet5 mgoralApotex Inc2002-12-20Not applicableCanada
Apo-simvastatintablet80 mgoralApotex Inc2002-12-20Not applicableCanada
Apo-simvastatintablet10 mgoralApotex Inc2002-12-20Not applicableCanada
Simvastatintablet, film coated10 mg/1oralCardinal Health2011-10-03Not applicableUs
Simvastatintablet, film coated10 mg/1oralREMEDYREPACK INC.2015-03-25Not applicableUs
Simvastatintablet, film coated80 mg/1oralbryant ranch prepack2008-02-26Not applicableUs
Simvastatintablet, film coated80 mg/1oralBiocon Limited2015-12-17Not applicableUs
Simvastatintablet, film coated5 mg/1oralContract Pharmacy Services Pa2010-08-25Not applicableUs
Simvastatintablet, film coated5 mg/1oralZydus Pharmaceuticals (USA) Inc.2006-12-20Not applicableUs
Simvastatintablet, film coated5 mg/1oralAurolife Pharma LLC2009-11-09Not applicableUs
Simvastatintablet, film coated20 mg/1oralPreferred Pharmaceuticals, Inc.2012-03-29Not applicableUs
Simvastatintablet, film coated5 mg/1oralLucid Pharma Llc2006-12-20Not applicableUs
Simvastatintablet, film coated20 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2006-12-20Not applicableUs
Simvastatintablet20 mg/1oralREMEDYREPACK INC.2011-12-08Not applicableUs
Simvastatintablet, film coated10 mg/1oralAccord Healthcare, Inc.2008-02-26Not applicableUs
Simvastatintablet, film coated5 mg/1oralBlu Pharmceuticals Llc2011-10-17Not applicableUs
Simvastatintablet, film coated10 mg/1oralLake Erie Medical DBA Quality Care Products LLC2008-02-26Not applicableUs
Simvastatintablet, film coated40 mg/1oralAphena Pharma Solutions Tennessee, Llc2006-12-20Not applicableUs
Simvastatintablet, film coated20 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-11-22Not applicableUs
Simvastatintablet, film coated20 mg/1oralMylan Institutional Inc.2006-07-10Not applicableUs
Simvastatintablet, film coated40 mg/1oralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
Simvastatintablet, film coated20 mg/1oralDr. Reddy's Laboratories Limited2006-12-20Not applicableUs
Simvastatintablet10 mg/1oralPhysicians Total Care, Inc.2007-02-02Not applicableUs
Simvastatintablet, film coated80 mg/1oralCardinal Health2006-12-20Not applicableUs
Simvastatintablet, film coated40 mg/1oralClinical Solutions Wholesale2008-02-26Not applicableUs
Simvastatintablet, film coated10 mg/1oralRanbaxy Pharmaceuticals Inc.2006-12-20Not applicableUs
Simvastatintablet, film coated40 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2012-11-22Not applicableUs
Simvastatintablet, film coated20 mg/1oralAurobindo Pharma Limited2006-12-20Not applicableUs
Simvastatintablet, film coated40 mg/1oralLupin Pharmaceuticals, Inc.2015-12-02Not applicableUs
Simvastatintablet, film coated10 mg/1oralMajor Pharmaceuticals2006-12-20Not applicableUs
Simvastatintablet20 mg/1oralLegacy Pharmaceutical Packaging, Llc2007-06-01Not applicableUs
Simvastatintablet, film coated40 mg/1oralMc Kesson Contract Packaging2013-02-19Not applicableUs
Simvastatintablet, film coated5 mg/1oralTeva Pharmaceuticals USA Inc2006-06-27Not applicableUs
Simvastatintablet, film coated20 mg/1oralLUPIN LIMITED2007-06-14Not applicableUs
Simvastatintablet40 mg/1oralCobalt Laboratories Inc.2006-12-20Not applicableUs
Simvastatintablet40 mg/1oralRebel Distributors Corp2008-07-08Not applicableUs
Simvastatintablet, film coated40 mg/1oralCamber Pharmaceuticals, Inc.2014-12-03Not applicableUs
Simvastatintablet10 mg/1oralMicro Labs Limited2013-06-13Not applicableUs
Simvastatintablet40 mg/1oralREMEDYREPACK INC.2011-07-08Not applicableUs
Simvastatintablet, film coated40 mg/1oralUnit Dose Services2008-02-26Not applicableUs
Simvastatintablet, film coated20 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Simvastatintablet, film coated80 mg/1oralAvera Mc Kennan Hospital2015-12-02Not applicableUs
Simvastatintablet, film coated5 mg/1oralAccord Healthcare, Inc.2013-09-02Not applicableUs
Simvastatintablet, film coated80 mg/1oralBlu Pharmceuticals Llc2011-10-17Not applicableUs
Simvastatintablet, film coated20 mg/1oralRebel Distributors Corp2008-02-26Not applicableUs
Simvastatintablet, film coated5 mg/1oralAphena Pharma Solutions Tennessee, Llc2006-12-20Not applicableUs
Simvastatintablet, film coated40 mg/1oralAv Pak2014-12-02Not applicableUs
Simvastatintablet, film coated40 mg/1oralH.J. Harkins Company, Inc.2008-02-26Not applicableUs
Simvastatintablet, film coated10 mg/1oralInternational Labs, Inc.2013-09-01Not applicableUs
Simvastatintablet, film coated20 mg/1oralCardinal Health2006-12-20Not applicableUs
Simvastatintablet, film coated10 mg/1oralPd Rx Pharmaceuticals, Inc.2006-06-27Not applicableUs
Simvastatintablet, film coated20 mg/1oralProficient Rx LP2008-02-26Not applicableUs
Simvastatintablet, film coated40 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2008-03-31Not applicableUs
Simvastatintablet, film coated40 mg/1oralCadila Healthcare Limited2006-12-20Not applicableUs
Simvastatintablet, film coated20 mg/1oralAmerican Health Packaging2011-05-02Not applicableUs
Simvastatintablet, film coated80 mg/1oralZydus Pharmaceuticals (USA) Inc.2006-12-20Not applicableUs
Simvastatintablet, film coated80 mg/1oralAurolife Pharma LLC2009-11-09Not applicableUs
Simvastatintablet, film coated10 mg/1oralMc Kesson Contract Packaging2011-10-13Not applicableUs
Simvastatintablet, film coated80 mg/1oralLucid Pharma Llc2006-12-20Not applicableUs
Simvastatintablet, film coated5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2006-12-20Not applicableUs
Simvastatintablet, film coated80 mg/1oralTeva Pharmaceuticals USA Inc2006-12-20Not applicableUs
Simvastatintablet, film coated10 mg/1oralPd Rx Pharmaceuticals, Inc.2006-12-20Not applicableUs
Simvastatintablet, film coated20 mg/1oralNorth Star Rx Llc2006-12-20Not applicableUs
Simvastatintablet, film coated20 mg/1oralBlu Pharmaceuticals, LLC2008-02-01Not applicableUs
Simvastatintablet, film coated10 mg/1oralAidarex Pharmaceuticals LLC2008-02-26Not applicableUs
Simvastatintablet, film coated80 mg/1oralPd Rx Pharmaceuticals, Inc.2006-12-20Not applicableUs
Simvastatintablet, film coated10 mg/1oralREMEDYREPACK INC.2013-05-01Not applicableUs
Simvastatintablet, film coated40 mg/1oralIngenus Pharmaceuticals, LLC2012-01-04Not applicableUs
Simvastatintablet, film coated5 mg/1oralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
Simvastatintablet5 mg/1oralPhysicians Total Care, Inc.2009-09-24Not applicableUs
Simvastatintablet, film coated20 mg/1oralCardinal Health2013-04-04Not applicableUs
Simvastatintablet, film coated40 mg/1oralSt Marys Medical Park Pharmacy2008-02-26Not applicableUs
Simvastatintablet, film coated40 mg/1oralbryant ranch prepack2008-02-26Not applicableUs
Simvastatintablet, film coated10 mg/1oralBiocon Limited2015-12-17Not applicableUs
Simvastatintablet, film coated20 mg/1oralMed Vantx, Inc.2006-12-20Not applicableUs
Simvastatintablet, film coated40 mg/1oralLupin Pharmaceuticals, Inc.2007-06-12Not applicableUs
Simvastatintablet, film coated40 mg/1oralBlenheim Pharmacal, Inc.2015-02-27Not applicableUs
Simvastatintablet, film coated80 mg/1oralPreferred Pharmaceuticals, Inc.2014-10-21Not applicableUs
Simvastatintablet, film coated10 mg/1oralState of Florida DOH Central Pharmacy2014-11-01Not applicableUs
Simvastatintablet, film coated40 mg/1oralDr. Reddy's Laboratories Limited2006-12-20Not applicableUs
Simvastatintablet, film coated10 mg/1oralCardinal Health2006-12-20Not applicableUs
Simvastatintablet, film coated20 mg/1oralREMEDYREPACK INC.2015-03-25Not applicableUs
Simvastatintablet, film coated5 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2008-03-31Not applicableUs
Simvastatintablet, film coated5 mg/1oralCadila Healthcare Limited2006-12-20Not applicableUs
Simvastatintablet, film coated40 mg/1oralContract Pharmacy Services Pa2010-06-17Not applicableUs
Simvastatintablet, film coated10 mg/1oralZydus Pharmaceuticals (USA) Inc.2006-12-20Not applicableUs
Simvastatintablet, film coated10 mg/1oralAurolife Pharma LLC2009-11-09Not applicableUs
Simvastatintablet, film coated40 mg/1oralPreferred Pharmaceuticals, Inc.2012-02-28Not applicableUs
Simvastatintablet, film coated10 mg/1oralLucid Pharma Llc2006-12-20Not applicableUs
Simvastatintablet, film coated40 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2006-12-20Not applicableUs
Simvastatintablet, film coated10 mg/1oralUnit Dose Services2008-02-26Not applicableUs
Simvastatintablet, film coated20 mg/1oralAccord Healthcare, Inc.2008-02-26Not applicableUs
Simvastatintablet, film coated10 mg/1oralBlu Pharmceuticals Llc2011-10-17Not applicableUs
Simvastatintablet, film coated40 mg/1oralLake Erie Medical DBA Quality Care Products LLC2008-02-26Not applicableUs
Simvastatintablet, film coated80 mg/1oralAphena Pharma Solutions Tennessee, Llc2006-12-20Not applicableUs
Simvastatintablet, film coated5 mg/1oralAv Pak2014-12-02Not applicableUs
Simvastatintablet, film coated40 mg/1oralMylan Institutional Inc.2006-07-10Not applicableUs
Simvastatintablet, film coated80 mg/1oralUnit Dose Services2008-02-26Not applicableUs
Simvastatintablet, film coated10 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Simvastatintablet20 mg/1oralPhysicians Total Care, Inc.2008-07-21Not applicableUs
Simvastatintablet, film coated10 mg/1oralCardinal Health2006-12-20Not applicableUs
Simvastatintablet, film coated80 mg/1oralClinical Solutions Wholesale2008-02-26Not applicableUs
Simvastatintablet, film coated20 mg/1oralRanbaxy Pharmaceuticals Inc.2006-12-20Not applicableUs
Simvastatintablet, film coated20 mg/1oralReady Meds2008-02-26Not applicableUs
Simvastatintablet, film coated40 mg/1oralAurobindo Pharma Limited2006-12-20Not applicableUs
Simvastatintablet, film coated80 mg/1oralLupin Pharmaceuticals, Inc.2015-12-02Not applicableUs
Simvastatintablet, film coated20 mg/1oralMajor Pharmaceuticals2006-12-20Not applicableUs
Simvastatintablet40 mg/1oralLegacy Pharmaceutical Packaging, Llc2007-06-01Not applicableUs
Simvastatintablet, film coated5 mg/1oralH.J. Harkins Company, Inc.2007-08-16Not applicableUs
Simvastatintablet, film coated10 mg/1oralTeva Pharmaceuticals USA Inc2006-06-27Not applicableUs
Simvastatintablet, film coated40 mg/1oralLUPIN LIMITED2015-11-23Not applicableUs
Simvastatintablet80 mg/1oralCobalt Laboratories Inc.2006-12-20Not applicableUs
Simvastatintablet80 mg/1oralRebel Distributors Corp2007-05-23Not applicableUs
Simvastatintablet, film coated80 mg/1oralCamber Pharmaceuticals, Inc.2014-12-09Not applicableUs
Simvastatintablet20 mg/1oralMicro Labs Limited2013-06-13Not applicableUs
Simvastatintablet20 mg/1oralREMEDYREPACK INC.2011-07-15Not applicableUs
Simvastatintablet, film coated20 mg/1oralMc Kesson Contract Packaging2011-08-18Not applicableUs
Simvastatintablet, film coated40 mg/1oralLUPIN LIMITED2015-12-02Not applicableUs
Simvastatintablet, film coated10 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2006-12-20Not applicableUs
Simvastatintablet5 mg/1oralRebel Distributors Corp2009-09-24Not applicableUs
Simvastatintablet, film coated5 mg/1oralCamber Pharmaceuticals, Inc.2014-12-09Not applicableUs
Simvastatintablet, film coated10 mg/1oralRebel Distributors Corp2008-02-26Not applicableUs
Simvastatintablet, film coated20 mg/1oralSafecor Health, LLC2014-09-30Not applicableUs
Simvastatintablet, film coated80 mg/1oralAv Pak2014-12-02Not applicableUs
Simvastatintablet, film coated20 mg/1oralH.J. Harkins Company, Inc.2008-02-26Not applicableUs
Simvastatintablet, film coated40 mg/1oralInternational Laboratories, Inc.2010-11-22Not applicableUs
Simvastatintablet, film coated40 mg/1oralCardinal Health2006-12-20Not applicableUs
Simvastatintablet, film coated40 mg/1oralPd Rx Pharmaceuticals, Inc.2011-06-13Not applicableUs
Simvastatintablet, film coated10 mg/1oralProficient Rx LP2008-02-26Not applicableUs
Simvastatintablet, film coated5 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2013-01-17Not applicableUs
Simvastatintablet, film coated80 mg/1oralCadila Healthcare Limited2006-12-20Not applicableUs
Simvastatintablet, film coated40 mg/1oralAmerican Health Packaging2011-05-02Not applicableUs
Simvastatintablet20 mg/1oralLegacy Pharmaceutical Packaging2010-10-01Not applicableUs
Simvastatintablet5 mg/1oralCobalt Laboratories Inc.2006-12-20Not applicableUs
Simvastatintablet, film coated80 mg/1oralLupin Pharmaceuticals, Inc.2007-06-12Not applicableUs
Simvastatintablet, film coated80 mg/1oralBlenheim Pharmacal, Inc.2015-03-26Not applicableUs
Simvastatintablet, film coated10 mg/1oralPreferred Pharmaceuticals, Inc.2012-02-28Not applicableUs
Simvastatintablet, film coated5 mg/1oralKAISER FOUNDATION HOSPITALS2013-02-01Not applicableUs
Simvastatintablet, film coated20 mg/1oralREMEDYREPACK INC.2016-03-28Not applicableUs
Simvastatintablet, film coated40 mg/1oralNorth Star Rx Llc2006-12-20Not applicableUs
Simvastatintablet, film coated40 mg/1oralBlu Pharmaceuticals, LLC2008-02-01Not applicableUs
Simvastatintablet, film coated20 mg/1oralRx Change Co.2008-02-26Not applicableUs
Simvastatintablet, film coated80 mg/1oralAphena Pharma Solutions Tennessee, Inc.2011-10-17Not applicableUs
Simvastatintablet40 mg/1oralREMEDYREPACK INC.2011-09-09Not applicableUs
Simvastatintablet, film coated80 mg/1oralIngenus Pharmaceuticals, LLC2012-01-04Not applicableUs
Simvastatintablet, film coated40 mg/1oralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
Simvastatintablet, film coated5 mg/1oralDr. Reddy's Laboratories Limited2007-08-16Not applicableUs
Simvastatintablet, film coated20 mg/1oralCardinal Health2011-10-03Not applicableUs
Simvastatintablet, film coated80 mg/1oralSt Marys Medical Park Pharmacy2008-02-26Not applicableUs
Simvastatintablet, film coated10 mg/1oralbryant ranch prepack2008-02-26Not applicableUs
Simvastatintablet, film coated20 mg/1oralBiocon Limited2015-12-17Not applicableUs
Simvastatintablet, film coated40 mg/1oralMed Vantx, Inc.2006-12-20Not applicableUs
Simvastatintablet, film coated10 mg/1oralAv Pak2014-12-02Not applicableUs
Simvastatintablet, film coated10 mg/1oralREMEDYREPACK INC.2013-05-24Not applicableUs
Simvastatintablet, film coated40 mg/1oralInternational Labs, Inc.2013-09-19Not applicableUs
Simvastatintablet, film coated80 mg/1oralDr. Reddy's Laboratories Limited2006-12-20Not applicableUs
Simvastatintablet, film coated5 mg/1oralCardinal Health2011-10-17Not applicableUs
Simvastatintablet, film coated40 mg/1oralDIRECT RX2014-01-01Not applicableUs
Simvastatintablet, film coated10 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2008-03-31Not applicableUs
Simvastatintablet, film coated10 mg/1oralCadila Healthcare Limited2006-12-20Not applicableUs
Simvastatintablet, film coated5 mg/1oralContract Pharmacy Services Pa2010-08-25Not applicableUs
Simvastatintablet, film coated20 mg/1oralZydus Pharmaceuticals (USA) Inc.2006-12-20Not applicableUs
Simvastatintablet, film coated20 mg/1oralAurolife Pharma LLC2009-11-09Not applicableUs
Simvastatintablet, film coated20 mg/1oralPreferred Pharmaceuticals, Inc.2012-02-28Not applicableUs
Simvastatintablet, film coated20 mg/1oralLucid Pharma Llc2006-12-20Not applicableUs
Simvastatintablet, film coated5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2007-08-16Not applicableUs
Simvastatintablet40 mg/1oralCardinal Health2011-05-02Not applicableUs
Simvastatintablet, film coated40 mg/1oralAccord Healthcare, Inc.2008-02-26Not applicableUs
Simvastatintablet, film coated20 mg/1oralBlu Pharmceuticals Llc2011-10-17Not applicableUs
Simvastatintablet, film coated20 mg/1oralLake Erie Medical DBA Quality Care Products LLC2008-02-26Not applicableUs
Simvastatintablet, film coated10 mg/1oralAphena Pharma Solutions Tennessee, Llc2006-12-20Not applicableUs
Simvastatintablet40 mg/1oralMicro Labs Limited2013-06-13Not applicableUs
Simvastatintablet10 mg/1oralREMEDYREPACK INC.2011-07-25Not applicableUs
Simvastatintablet, film coated10 mg/1oralIngenus Pharmaceuticals, LLC2012-01-04Not applicableUs
Simvastatintablet, film coated10 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Simvastatintablet40 mg/1oralPhysicians Total Care, Inc.2008-07-08Not applicableUs
Simvastatintablet, film coated5 mg/1oralCardinal Health2006-06-27Not applicableUs
Simvastatintablet10 mg/1oralClinical Solutions Wholesale2007-06-01Not applicableUs
Simvastatintablet, film coated40 mg/1oralRanbaxy Pharmaceuticals Inc.2006-12-20Not applicableUs
Simvastatintablet, film coated40 mg/1oralReady Meds2008-02-26Not applicableUs
Simvastatintablet, film coated80 mg/1oralAurobindo Pharma Limited2006-12-20Not applicableUs
Simvastatintablet, film coated10 mg/1oralLupin Pharmaceuticals, Inc.2007-06-12Not applicableUs
Simvastatintablet, film coated40 mg/1oralMajor Pharmaceuticals2006-12-20Not applicableUs
Simvastatintablet80 mg/1oralLegacy Pharmaceutical Packaging, Llc2007-06-01Not applicableUs
Simvastatintablet, film coated20 mg/1oralTeva Pharmaceuticals USA Inc2006-06-27Not applicableUs
Simvastatintablet, film coated80 mg/1oralLUPIN LIMITED2015-11-23Not applicableUs
Simvastatintablet, film coated5 mg/1oralNorth Star Rx Llc2006-12-20Not applicableUs
Simvastatintablet, film coated5 mg/1oralBlu Pharmaceuticals, LLC2008-02-01Not applicableUs
Simvastatintablet, film coated20 mg/1oralAidarex Pharmaceuticals LLC2008-02-26Not applicableUs
Simvastatintablet, film coated80 mg/1oralAmerican Health Packaging2011-05-02Not applicableUs
Simvastatintablet40 mg/1oralLegacy Pharmaceutical Packaging2010-10-01Not applicableUs
Simvastatintablet10 mg/1oralCobalt Laboratories Inc.2006-12-20Not applicableUs
Simvastatintablet, film coated40 mg/1oralMc Kesson Contract Packaging2011-10-14Not applicableUs
Simvastatintablet, film coated80 mg/1oralLUPIN LIMITED2015-12-02Not applicableUs
Simvastatintablet, film coated20 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2006-12-20Not applicableUs
Simvastatintablet10 mg/1oralRebel Distributors Corp2007-02-02Not applicableUs
Simvastatintablet, film coated10 mg/1oralCamber Pharmaceuticals, Inc.2014-12-09Not applicableUs
Simvastatintablet, film coated80 mg/1oralRebel Distributors Corp2008-02-26Not applicableUs
Simvastatintablet20 mg/1oralREMEDYREPACK INC.2010-09-21Not applicableUs
Simvastatintablet, film coated20 mg/1oralUnit Dose Services2008-02-26Not applicableUs
Simvastatintablet, film coated40 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Simvastatintablet, film coated20 mg/1oralInternational Laboratories, Inc.2010-11-27Not applicableUs
Simvastatintablet, film coated20 mg/1oralCardinal Health2006-12-20Not applicableUs
Simvastatintablet, film coated20 mg/1oralLake Erie Medical DBA Quality Care Products LLC2012-03-29Not applicableUs
Simvastatintablet, film coated40 mg/1oralProficient Rx LP2008-02-26Not applicableUs
Simvastatintablet, film coated10 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2012-12-20Not applicableUs
Simvastatintablet, film coated5 mg/1oralAurobindo Pharma Limited2006-12-20Not applicableUs
Simvastatintablet, film coated40 mg/1oralBiocon Limited2015-12-17Not applicableUs
Simvastatintablet, film coated20 mg/1oralContract Pharmacy Services Pa2010-06-17Not applicableUs
Simvastatintablet, film coated5 mg/1oralLupin Pharmaceuticals, Inc.2009-07-14Not applicableUs
Simvastatintablet, film coated20 mg/1oralBlenheim Pharmacal, Inc.2015-03-26Not applicableUs
Simvastatintablet, film coated40 mg/1oralPreferred Pharmaceuticals, Inc.2012-03-29Not applicableUs
Simvastatintablet, film coated10 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2006-12-20Not applicableUs
Simvastatintablet, film coated40 mg/1oralPd Rx Pharmaceuticals, Inc.2015-08-12Not applicableUs
Simvastatintablet, film coated80 mg/1oralNorth Star Rx Llc2006-12-20Not applicableUs
Simvastatintablet, film coated80 mg/1oralBlu Pharmaceuticals, LLC2008-02-01Not applicableUs
Simvastatintablet, film coated40 mg/1oralRx Change Co.2014-11-27Not applicableUs
Simvastatintablet, film coated20 mg/1oralAphena Pharma Solutions Tennessee, Inc.2011-10-17Not applicableUs
Simvastatintablet, film coated20 mg/1oralREMEDYREPACK INC.2013-05-14Not applicableUs
Simvastatintablet, film coated10 mg/1oralMylan Institutional Inc.2006-07-10Not applicableUs
Simvastatintablet, film coated10 mg/1oralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
Simvastatintablet, film coated10 mg/1oralDr. Reddy's Laboratories Limited2006-12-20Not applicableUs
Simvastatintablet, film coated40 mg/1oralCardinal Health2011-10-03Not applicableUs
Simvastatintablet, film coated10 mg/1oralSt Marys Medical Park Pharmacy2014-04-21Not applicableUs
Simvastatintablet, film coated20 mg/1oralbryant ranch prepack2008-02-26Not applicableUs
Simvastatintablet, film coated40 mg/1oralRebel Distributors Corp2008-02-26Not applicableUs
Simvastatintablet, film coated20 mg/1oralAphena Pharma Solutions Tennessee, Llc2006-12-20Not applicableUs
Simvastatintablet, film coated20 mg/1oralAv Pak2014-12-02Not applicableUs
Simvastatintablet, film coated80 mg/1oralREMEDYREPACK INC.2013-02-19Not applicableUs
Simvastatintablet, film coated20 mg/1oralInternational Labs, Inc.2013-09-01Not applicableUs
Simvastatintablet, film coated20 mg/1oralCardinal Health2008-02-26Not applicableUs
Simvastatintablet, film coated20 mg/1oralPd Rx Pharmaceuticals, Inc.2011-06-13Not applicableUs
Simvastatintablet, film coated20 mg/1oralDIRECT RX2014-01-01Not applicableUs
Simvastatintablet, film coated20 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2008-03-31Not applicableUs
Simvastatintablet, film coated20 mg/1oralCadila Healthcare Limited2006-12-20Not applicableUs
Simvastatintablet, film coated10 mg/1oralAmerican Health Packaging2011-05-02Not applicableUs
Simvastatintablet, film coated40 mg/1oralZydus Pharmaceuticals (USA) Inc.2006-12-20Not applicableUs
Simvastatintablet, film coated40 mg/1oralAurolife Pharma LLC2009-11-09Not applicableUs
Simvastatintablet, film coated40 mg/1oralLife Line Home Care Services, Inc.2006-12-20Not applicableUs
Simvastatintablet, film coated40 mg/1oralLucid Pharma Llc2006-12-20Not applicableUs
Simvastatintablet, film coated80 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2006-12-20Not applicableUs
Simvastatintablet20 mg/1oralCardinal Health2011-05-02Not applicableUs
Simvastatintablet, film coated80 mg/1oralAccord Healthcare, Inc.2008-02-26Not applicableUs
Simvastatintablet, film coated40 mg/1oralBlu Pharmceuticals Llc2011-10-17Not applicableUs
Simvastatintablet, film coated10 mg/1oralBlu Pharmaceuticals, LLC2008-02-01Not applicableUs
Simvastatintablet, film coated40 mg/1oralAidarex Pharmaceuticals LLC2008-02-26Not applicableUs
Simvastatintablet80 mg/1oralMicro Labs Limited2013-06-13Not applicableUs
Simvastatintablet40 mg/1oralREMEDYREPACK INC.2011-08-01Not applicableUs
Simvastatintablet, film coated20 mg/1oralIngenus Pharmaceuticals, LLC2012-01-04Not applicableUs
Simvastatintablet, film coated20 mg/1oralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
Simvastatintablet80 mg/1oralPhysicians Total Care, Inc.2007-05-23Not applicableUs
Simvastatintablet, film coated10 mg/1oralCardinal Health2013-04-04Not applicableUs
Simvastatintablet, film coated20 mg/1oralSt Marys Medical Park Pharmacy2008-02-26Not applicableUs
Simvastatintablet, film coated80 mg/1oralRanbaxy Pharmaceuticals Inc.2006-12-20Not applicableUs
Simvastatintablet, film coated5 mg/1oralBiocon Limited2015-12-17Not applicableUs
Simvastatintablet, film coated20 mg/1oralMed Vantx, Inc.2006-06-27Not applicableUs
Simvastatintablet, film coated20 mg/1oralLupin Pharmaceuticals, Inc.2007-06-14Not applicableUs
Simvastatintablet, film coated20 mg/1oralBlenheim Pharmacal, Inc.2014-02-10Not applicableUs
Simvastatintablet, film coated40 mg/1oralPreferred Pharmaceuticals, Inc.2014-07-03Not applicableUs
Simvastatintablet, film coated40 mg/1oralTeva Pharmaceuticals USA Inc2006-06-27Not applicableUs
Simvastatintablet, film coated5 mg/1oralLUPIN LIMITED2009-07-14Not applicableUs
Simvastatintablet, film coated10 mg/1oralNorth Star Rx Llc2006-12-20Not applicableUs
Simvastatintablet, film coated20 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2012-11-22Not applicableUs
Simvastatintablet, film coated10 mg/1oralAurobindo Pharma Limited2006-12-20Not applicableUs
Simvastatintablet, film coated5 mg/1oralCarilion Materials Management2006-06-27Not applicableUs
Simvastatintablet, film coated80 mg/1oralLegacy Pharmaceutical Packaging2006-12-20Not applicableUs
Simvastatintablet20 mg/1oralCobalt Laboratories Inc.2006-12-20Not applicableUs
Simvastatintablet, film coated40 mg/1oralMc Kesson Contract Packaging2012-10-26Not applicableUs
Simvastatintablet, film coated10 mg/1oralLUPIN LIMITED2007-06-12Not applicableUs
Simvastatintablet, film coated40 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2012-06-14Not applicableUs
Simvastatintablet20 mg/1oralRebel Distributors Corp2008-07-21Not applicableUs
Simvastatintablet, film coated20 mg/1oralCamber Pharmaceuticals, Inc.2014-12-09Not applicableUs
Simvastatintablet5 mg/1oralMicro Labs Limited2013-06-13Not applicableUs
Simvastatintablet40 mg/1oralREMEDYREPACK INC.2011-04-14Not applicableUs
Simvastatintablet, film coated20 mg/1oralUnit Dose Services2008-02-26Not applicableUs
Simvastatintablet, film coated20 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Simvastatintablet, film coated10 mg/1oralInternational Laboratories, Inc.2010-11-28Not applicableUs
Simvastatintablet, film coated40 mg/1oralCardinal Health2006-12-20Not applicableUs
Simvastatintablet, film coated20 mg/1oralClinical Solutions Wholesale2008-02-26Not applicableUs
Simvastatintablet, film coated5 mg/1oralRanbaxy Pharmaceuticals Inc.2006-12-20Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
CholestatKalbe
ColeminBiohorm
LabistatinSandoz
LipexMerck Sharp & Dohme
LodalesSanofi-Aventis
MedipoMediolanum Farmaceutici
NivelipolTemis-Lostalo
SimovilMerck Sharp & Dohme
SinvacorMerck Sharp & Dohme
SivastinSigma-Tau
SivatinRowex
SivinarAnfarm
SorfoxGalex
SotovastinBros
StarezinLeovan Pharmaceuticals
StarstatLupin
StarzokoDaewoong
StasivaPharmanel
StatexPliva
StaticorDarnitsa
StatinalAlet Pharmaceuticals
StativerIapharm
Brand mixtures
NameLabellerIngredients
SimcorAbb Vie Inc.
VytorinRebel Distributors Corp
SaltsNot Available
Categories
UNIIAGG2FN16EV
CAS number79902-63-9
WeightAverage: 418.5662
Monoisotopic: 418.271924326
Chemical FormulaC25H38O5
InChI KeyInChIKey=RYMZZMVNJRMUDD-HGQWONQESA-N
InChI
InChI=1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1
IUPAC Name
(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
SMILES
[H][C@]12[[email protected]](C[C@@H](C)C=C1C=C[[email protected]](C)[C@@H]2CC[C@@H]1C[C@@H](O)CC(=O)O1)OC(=O)C(C)(C)CC
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as delta valerolactones. These are cyclic organic compounds containing an oxan-2- one moiety.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassLactones
Sub ClassDelta valerolactones
Direct ParentDelta valerolactones
Alternative Parents
Substituents
  • Delta_valerolactone
  • Fatty acid ester
  • Delta valerolactone
  • Fatty acyl
  • Oxane
  • Dicarboxylic acid or derivatives
  • Saccharide
  • Secondary alcohol
  • Carboxylic acid ester
  • Oxacycle
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Alcohol
  • Aliphatic heteropolycyclic compound
Molecular FrameworkAliphatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of hypercholesterolemia and for the reduction in the risk of cardiac heart disease mortality and cardiovascular events. It can also be used in adolescent patients for the treatment of heterozygous familial hypercholesterolemia.
PharmacodynamicsSimvastatin, the methylated form of lovastatin, is an oral antilipemic agent which inhibits HMG-CoA reductase. Simvastatin is used in the treatment of primary hypercholesterolemia and is effective in reducing total and LDL-cholesterol as well as plasma triglycerides and apolipoprotein B.
Mechanism of actionSimvastatin is a prodrug in which the 6-membered lactone ring of simvastatin is hydrolyzed in vivo to generate the beta,delta-dihydroxy acid, an active metabolite structurally similar to HMG-CoA (hydroxymethylglutaryl CoA). Once hydrolyzed, simvastatin competes with HMG-CoA for HMG-CoA reductase, a hepatic microsomal enzyme. Interference with the activity of this enzyme reduces the quantity of mevalonic acid, a precursor of cholesterol.
Related Articles
AbsorptionAbsorption of simvastatin, estimated relative to an intravenous reference dose, in each of two animal species tested, averaged about 85% of an oral dose. In animal studies, after oral dosing, simvastatin achieved substantially higher concentrations in the liver than in non-target tissues. However, because simvastatin undergoes extensive first-pass metabolism, the availability of the drug in the systemic is low. Peak plasma concentration occurs 1.3 - 2.4 hours after administration.
Volume of distribution

Simvastatin can cross the blood-brain-barrier.

Protein bindingBoth simvastatin and its β-hydroxyacid metabolite are highly bound (approximately 95%) to human plasma proteins.
Metabolism

Hepatic, simvastatin is a substrate for CYP3A4. The major active metabolites of simvastatin are β-hydroxyacid metabolite and its 6'-hydroxy, 6'-hydroxymethyl, and 6'-exomethylene derivatives

SubstrateEnzymesProduct
Simvastatin
simvastatin hydroxy acidDetails
Route of eliminationFollowing an oral dose of 14C-labeled simvastatin in man, 13% of the dose was excreted in urine and 60% in feces.
Half life3 hours
ClearanceNot Available
ToxicityThe most common adverse reactions that lead to discontinuation of therapy include gastrointestinal disorders (0.5%), myalgia (0.1%), and arthralgia (0.1%).
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Simvastatin Action PathwayDrug actionSMP00082
SNP Mediated Effects
Interacting Gene/EnzymeSNP RS IDAllele nameDefining changeEffectReference(s)
Kinesin-like protein KIF6
Gene symbol: KIF6
UniProt: Q6ZMV9
rs20455 Not AvailableC AlleleImproved response to statin drugs18222353
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Gene symbol: HMGCR
UniProt: P04035
rs17244841 Not AvailableT AlleleReduced response to statin drugs15199031
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9475
Blood Brain Barrier+0.9422
Caco-2 permeable-0.5951
P-glycoprotein substrateSubstrate0.8508
P-glycoprotein inhibitor IInhibitor0.7335
P-glycoprotein inhibitor IIInhibitor0.8387
Renal organic cation transporterNon-inhibitor0.8435
CYP450 2C9 substrateNon-substrate0.835
CYP450 2D6 substrateNon-substrate0.9254
CYP450 3A4 substrateSubstrate0.7513
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorNon-inhibitor0.9307
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorInhibitor0.7959
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8682
Ames testNon AMES toxic0.792
CarcinogenicityNon-carcinogens0.9408
BiodegradationNot ready biodegradable0.9657
Rat acute toxicity2.0061 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8921
hERG inhibition (predictor II)Non-inhibitor0.8573
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Synthon pharmaceuticals ltd
  • Accord healthcare inc
  • Aurobindo pharma ltd
  • Dr reddys laboratories inc
  • Dr reddys laboratories ltd
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Lupin ltd
  • Matrix laboratories ltd
  • Perrigo r and d co
  • Ranbaxy laboratories ltd
  • Sandoz inc
  • Watson laboratories inc
  • Zydus pharmaceuticals usa inc
  • Merck research laboratories div merck co inc
Packagers
Dosage forms
FormRouteStrength
Tabletoral5 mg
Tabletoral80 mg
Tablet, film coated, extended releaseoral
Tabletoral10 mg/1
Tabletoral20 mg/1
Tabletoral40 mg/1
Tabletoral5 mg/1
Tabletoral80 mg/1
Tabletoral
Tabletoral10 mg
Tabletoral20 mg
Tabletoral40 mg
Tablet, film coatedoral10 mg/1
Tablet, film coatedoral20 mg/1
Tablet, film coatedoral40 mg/1
Tablet, film coatedoral5 mg/1
Tablet, film coatedoral80 mg/1
Prices
Unit descriptionCostUnit
Zocor 90 40 mg tablet Bottle525.16USD bottle
Simvastatin 100% powder10.71USD g
Vytorin 10-20 mg tablet5.05USD tablet
Vytorin 10-40 mg tablet5.05USD tablet
Vytorin 10-10 mg tablet4.97USD tablet
Zocor 20 mg tablet4.69USD tablet
Zocor 80 mg tablet4.69USD tablet
Vytorin 10-80 mg tablet4.63USD tablet
Zocor 40 mg tablet4.11USD tablet
Simvastatin 20 mg tablet3.83USD tablet
Simvastatin 40 mg tablet3.83USD tablet
Simvastatin 80 mg tablet3.83USD tablet
Zocor 10 mg tablet2.89USD tablet
Simvastatin 10 mg tablet2.31USD tablet
Zocor 5 mg tablet1.99USD tablet
Simvastatin 5 mg tablet1.63USD tablet
Phl-Simvastatin 40 mg Tablet1.45USD tablet
Phl-Simvastatin 80 mg Tablet1.45USD tablet
Pms-Simvastatin 20 mg Tablet1.45USD tablet
Pms-Simvastatin 40 mg Tablet1.45USD tablet
Pms-Simvastatin 80 mg Tablet1.45USD tablet
Ran-Simvastatin 20 mg Tablet1.45USD tablet
Ran-Simvastatin 40 mg Tablet1.45USD tablet
Ran-Simvastatin 80 mg Tablet1.45USD tablet
Ratio-Simvastatin 20 mg Tablet1.45USD tablet
Ratio-Simvastatin 40 mg Tablet1.45USD tablet
Ratio-Simvastatin 80 mg Tablet1.45USD tablet
Sandoz Simvastatin 20 mg Tablet1.45USD tablet
Sandoz Simvastatin 40 mg Tablet1.45USD tablet
Sandoz Simvastatin 80 mg Tablet1.45USD tablet
Apo-Simvastatin 20 mg Tablet1.45USD tablet
Apo-Simvastatin 40 mg Tablet1.45USD tablet
Apo-Simvastatin 80 mg Tablet1.45USD tablet
Co Simvastatin 20 mg Tablet1.45USD tablet
Co Simvastatin 40 mg Tablet1.45USD tablet
Co Simvastatin 80 mg Tablet1.45USD tablet
Jamp-Simvastatin 20 mg Tablet1.45USD tablet
Jamp-Simvastatin 40 mg Tablet1.45USD tablet
Jamp-Simvastatin 80 mg Tablet1.45USD tablet
Mylan-Simvastatin 20 mg Tablet1.45USD tablet
Mylan-Simvastatin 40 mg Tablet1.45USD tablet
Mylan-Simvastatin 80 mg Tablet1.45USD tablet
Novo-Simvastatin 20 mg Tablet1.45USD tablet
Novo-Simvastatin 40 mg Tablet1.45USD tablet
Novo-Simvastatin 80 mg Tablet1.45USD tablet
Phl-Simvastatin 20 mg Tablet1.45USD tablet
Apo-Simvastatin 10 mg Tablet1.17USD tablet
Co Simvastatin 10 mg Tablet1.17USD tablet
Jamp-Simvastatin 10 mg Tablet1.17USD tablet
Mylan-Simvastatin 10 mg Tablet1.17USD tablet
Novo-Simvastatin 10 mg Tablet1.17USD tablet
Phl-Simvastatin 10 mg Tablet1.17USD tablet
Pms-Simvastatin 10 mg Tablet1.17USD tablet
Ran-Simvastatin 10 mg Tablet1.17USD tablet
Ratio-Simvastatin 10 mg Tablet1.17USD tablet
Sandoz Simvastatin 10 mg Tablet1.17USD tablet
Apo-Simvastatin 5 mg Tablet0.59USD tablet
Co Simvastatin 5 mg Tablet0.59USD tablet
Jamp-Simvastatin 5 mg Tablet0.59USD tablet
Mylan-Simvastatin 5 mg Tablet0.59USD tablet
Novo-Simvastatin 5 mg Tablet0.59USD tablet
Phl-Simvastatin 5 mg Tablet0.59USD tablet
Pms-Simvastatin 5 mg Tablet0.59USD tablet
Ran-Simvastatin 5 mg Tablet0.59USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5846966 No1993-09-212013-09-21Us
US6080428 No1997-05-272017-05-27Us
US6303661 No1997-04-242017-04-24Us
US6469035 No1998-03-152018-03-15Us
US6699871 No2002-07-262022-07-26Us
US6890898 No1999-02-022019-02-02Us
US7078381 No1999-02-022019-02-02Us
US7125873 No2002-07-262022-07-26Us
US7326708 No2006-04-112026-04-11Us
US7459428 No1999-02-022019-02-02Us
US8168637 No2002-06-262022-06-26Us
USRE37721 Yes1997-04-252017-04-25Us
USRE42461 Yes1997-04-252017-04-25Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point135-138 °CPhysProp
water solubilityInsoluble FDA label
logP4.68HANSCH,C ET AL. (1995)
Predicted Properties
PropertyValueSource
Water Solubility0.0122 mg/mLALOGPS
logP4.51ALOGPS
logP4.46ChemAxon
logS-4.5ALOGPS
pKa (Strongest Acidic)14.91ChemAxon
pKa (Strongest Basic)-2.8ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area72.83 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity117.68 m3·mol-1ChemAxon
Polarizability47.85 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
MSMass Spectrum (Electron Ionization)splash10-0a4i-3900000000-d04758924bf88a90c017View in MoNA
References
Synthesis Reference

Shieh-Shung J. Chen, Byron H. Arison, “Process for the preparation of 3-keto, 5-hydroxy simvastatin analogs.” U.S. Patent US4965200, issued April, 1981.

US4965200
General References
  1. Wolozin B, Wang SW, Li NC, Lee A, Lee TA, Kazis LE: Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease. BMC Med. 2007 Jul 19;5:20. [PubMed:17640385 ]
External Links
ATC CodesC10BA02C10BX04A10BH51C10BA04C10AA01C10BX01
AHFS Codes
  • 24:06.08
PDB EntriesNot Available
FDA labelDownload (102 KB)
MSDSDownload (87.5 KB)
Interactions
Drug Interactions
Drug
1,10-PhenanthrolineThe serum concentration of Simvastatin can be increased when it is combined with 1,10-Phenanthroline.
3,4-DichloroisocoumarinThe serum concentration of Simvastatin can be increased when it is combined with 3,4-Dichloroisocoumarin.
4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDEThe serum concentration of Simvastatin can be increased when it is combined with 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE.
AbirateroneThe serum concentration of Simvastatin can be increased when it is combined with Abiraterone.
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Simvastatin.
AcenocoumarolSimvastatin may increase the anticoagulant activities of Acenocoumarol.
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Simvastatin.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Simvastatin.
AcipimoxAcipimox may increase the myopathic rhabdomyolysis activities of Simvastatin.
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Simvastatin.
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Simvastatin.
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Simvastatin.
AlogliptinThe serum concentration of Simvastatin can be increased when it is combined with Alogliptin.
Alpha-1-proteinase inhibitorThe serum concentration of Simvastatin can be increased when it is combined with Alpha-1-proteinase inhibitor.
Aluminum hydroxideThe serum concentration of Simvastatin can be decreased when it is combined with Aluminum hydroxide.
Aluminum phosphateThe serum concentration of Simvastatin can be decreased when it is combined with Aluminum phosphate.
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Simvastatin.
AmiodaroneThe serum concentration of Simvastatin can be increased when it is combined with Amiodarone.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Simvastatin.
AmlodipineThe serum concentration of Simvastatin can be increased when it is combined with Amlodipine.
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Simvastatin.
AmprenavirThe serum concentration of Simvastatin can be increased when it is combined with Amprenavir.
Antithrombin III humanThe serum concentration of Simvastatin can be increased when it is combined with Antithrombin III human.
ApixabanThe serum concentration of Simvastatin can be increased when it is combined with Apixaban.
AprepitantThe serum concentration of Simvastatin can be increased when it is combined with Aprepitant.
AprotininThe serum concentration of Simvastatin can be increased when it is combined with Aprotinin.
ArgatrobanThe serum concentration of Simvastatin can be increased when it is combined with Argatroban.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Simvastatin.
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Simvastatin.
ArtemetherThe metabolism of Simvastatin can be decreased when combined with Artemether.
AsunaprevirThe serum concentration of Simvastatin can be increased when it is combined with Asunaprevir.
AtazanavirThe serum concentration of Simvastatin can be increased when it is combined with Atazanavir.
AtenololThe serum concentration of Atenolol can be increased when it is combined with Simvastatin.
AtomoxetineThe metabolism of Simvastatin can be decreased when combined with Atomoxetine.
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Simvastatin.
AzithromycinAzithromycin may increase the myopathic rhabdomyolysis activities of Simvastatin.
BatimastatThe serum concentration of Simvastatin can be increased when it is combined with Batimastat.
BenazeprilThe serum concentration of Simvastatin can be increased when it is combined with Benazepril.
BenzamidineThe serum concentration of Simvastatin can be increased when it is combined with Benzamidine.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Simvastatin.
BetaxololThe metabolism of Simvastatin can be decreased when combined with Betaxolol.
BexaroteneThe serum concentration of Simvastatin can be decreased when it is combined with Bexarotene.
BezafibrateBezafibrate may increase the myopathic rhabdomyolysis activities of Simvastatin.
Bismuth SubcitrateThe serum concentration of Simvastatin can be decreased when it is combined with Bismuth Subcitrate.
BivalirudinThe serum concentration of Simvastatin can be increased when it is combined with Bivalirudin.
BoceprevirThe serum concentration of Simvastatin can be increased when it is combined with Boceprevir.
BortezomibThe metabolism of Simvastatin can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Simvastatin can be decreased when it is combined with Bosentan.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Simvastatin.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Simvastatin.
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Simvastatin.
BupropionThe metabolism of Simvastatin can be decreased when combined with Bupropion.
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Simvastatin.
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Simvastatin.
Calcium carbonateThe serum concentration of Simvastatin can be decreased when it is combined with Calcium carbonate.
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Simvastatin.
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Simvastatin.
CandoxatrilThe serum concentration of Simvastatin can be increased when it is combined with Candoxatril.
CaptoprilThe serum concentration of Simvastatin can be increased when it is combined with Captopril.
CarbamazepineThe metabolism of Simvastatin can be increased when combined with Carbamazepine.
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Simvastatin.
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Simvastatin.
CelecoxibThe metabolism of Simvastatin can be decreased when combined with Celecoxib.
CeritinibThe serum concentration of Simvastatin can be increased when it is combined with Ceritinib.
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Simvastatin.
ChloroquineThe metabolism of Simvastatin can be decreased when combined with Chloroquine.
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Simvastatin.
ChlorpromazineThe metabolism of Simvastatin can be decreased when combined with Chlorpromazine.
CholecalciferolThe metabolism of Simvastatin can be decreased when combined with Cholecalciferol.
ChymostatinThe serum concentration of Simvastatin can be increased when it is combined with Chymostatin.
CilastatinThe serum concentration of Simvastatin can be increased when it is combined with Cilastatin.
CilazaprilThe serum concentration of Simvastatin can be increased when it is combined with Cilazapril.
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Simvastatin.
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Simvastatin.
CimetidineThe metabolism of Simvastatin can be decreased when combined with Cimetidine.
CinacalcetThe metabolism of Simvastatin can be decreased when combined with Cinacalcet.
CiprofibrateThe risk or severity of adverse effects can be increased when Ciprofibrate is combined with Simvastatin.
CiprofloxacinThe serum concentration of Ciprofloxacin can be increased when it is combined with Simvastatin.
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Simvastatin.
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Simvastatin.
CitalopramThe metabolism of Simvastatin can be decreased when combined with Citalopram.
ClarithromycinThe serum concentration of Simvastatin can be increased when it is combined with Clarithromycin.
ClemastineThe metabolism of Simvastatin can be decreased when combined with Clemastine.
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Simvastatin.
ClobazamThe metabolism of Simvastatin can be decreased when combined with Clobazam.
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Simvastatin.
ClomipramineThe metabolism of Simvastatin can be decreased when combined with Clomipramine.
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Simvastatin.
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Simvastatin.
ClopidogrelThe metabolism of Simvastatin can be decreased when combined with Clopidogrel.
ClotrimazoleThe metabolism of Simvastatin can be decreased when combined with Clotrimazole.
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Simvastatin.
ClozapineThe metabolism of Simvastatin can be decreased when combined with Clozapine.
CobicistatThe serum concentration of Simvastatin can be increased when it is combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Simvastatin.
CocaineThe metabolism of Simvastatin can be decreased when combined with Cocaine.
ColchicineColchicine may increase the myopathic rhabdomyolysis activities of Simvastatin.
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Simvastatin.
ConivaptanThe serum concentration of Simvastatin can be increased when it is combined with Conivaptan.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Simvastatin.
CrizotinibThe metabolism of Simvastatin can be decreased when combined with Crizotinib.
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Simvastatin.
CyclosporineThe serum concentration of Simvastatin can be increased when it is combined with Cyclosporine.
Cyproterone acetateThe serum concentration of Simvastatin can be increased when it is combined with Cyproterone acetate.
Dabigatran etexilateThe serum concentration of Simvastatin can be increased when it is combined with Dabigatran etexilate.
DabrafenibThe serum concentration of Simvastatin can be decreased when it is combined with Dabrafenib.
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Simvastatin.
DaclatasvirThe serum concentration of Simvastatin can be increased when it is combined with Daclatasvir.
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Simvastatin.
DanazolThe serum concentration of Simvastatin can be increased when it is combined with Danazol.
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Simvastatin.
DaptomycinThe risk or severity of adverse effects can be increased when Simvastatin is combined with Daptomycin.
DarifenacinThe metabolism of Simvastatin can be decreased when combined with Darifenacin.
DarunavirThe serum concentration of Simvastatin can be increased when it is combined with Darunavir.
DasatinibThe serum concentration of Simvastatin can be increased when it is combined with Dasatinib.
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Simvastatin.
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Simvastatin.
DeferasiroxThe serum concentration of Simvastatin can be decreased when it is combined with Deferasirox.
DelavirdineThe metabolism of Simvastatin can be decreased when combined with Delavirdine.
DesipramineThe metabolism of Simvastatin can be decreased when combined with Desipramine.
DexamethasoneThe serum concentration of Simvastatin can be decreased when it is combined with Dexamethasone.
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Simvastatin.
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Simvastatin.
DicoumarolSimvastatin may increase the anticoagulant activities of Dicoumarol.
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Simvastatin.
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Simvastatin.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Simvastatin.
DihydroergotamineThe metabolism of Simvastatin can be decreased when combined with Dihydroergotamine.
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Simvastatin.
DiltiazemThe metabolism of Simvastatin can be decreased when combined with Diltiazem.
DiltiazemThe serum concentration of Diltiazem can be increased when it is combined with Simvastatin.
DiphenhydramineThe metabolism of Simvastatin can be decreased when combined with Diphenhydramine.
DipyridamoleThe serum concentration of Dipyridamole can be increased when it is combined with Simvastatin.
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Simvastatin.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Simvastatin.
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Simvastatin.
DoxycyclineThe metabolism of Simvastatin can be decreased when combined with Doxycycline.
DronedaroneThe metabolism of Simvastatin can be decreased when combined with Dronedarone.
DuloxetineThe metabolism of Simvastatin can be decreased when combined with Duloxetine.
EcabetThe serum concentration of Simvastatin can be increased when it is combined with Ecabet.
EdoxabanThe serum concentration of Simvastatin can be increased when it is combined with Edoxaban.
EfavirenzThe serum concentration of Simvastatin can be decreased when it is combined with Efavirenz.
ElafinThe serum concentration of Simvastatin can be increased when it is combined with Elafin.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Simvastatin.
EliglustatThe metabolism of Simvastatin can be decreased when combined with Eliglustat.
EltrombopagThe serum concentration of Simvastatin can be increased when it is combined with Eltrombopag.
EnalaprilThe serum concentration of Simvastatin can be increased when it is combined with Enalapril.
EnalaprilatThe serum concentration of Simvastatin can be increased when it is combined with Enalaprilat.
EnalkirenThe serum concentration of Simvastatin can be increased when it is combined with Enalkiren.
EnzalutamideThe serum concentration of Simvastatin can be decreased when it is combined with Enzalutamide.
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Simvastatin.
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Simvastatin.
ErythromycinThe serum concentration of Simvastatin can be increased when it is combined with Erythromycin.
Eslicarbazepine acetateThe serum concentration of Simvastatin can be decreased when it is combined with Eslicarbazepine acetate.
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Simvastatin.
EstriolThe serum concentration of Estriol can be increased when it is combined with Simvastatin.
EstroneThe serum concentration of Estrone can be increased when it is combined with Simvastatin.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Simvastatin.
Ethyl biscoumacetateSimvastatin may increase the anticoagulant activities of Ethyl biscoumacetate.
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Simvastatin.
EtravirineThe serum concentration of Simvastatin can be decreased when it is combined with Etravirine.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Simvastatin.
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Simvastatin.
FelodipineThe metabolism of Simvastatin can be decreased when combined with Felodipine.
FenofibrateThe risk or severity of adverse effects can be increased when Fenofibrate is combined with Simvastatin.
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Simvastatin.
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Simvastatin.
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Simvastatin.
FluconazoleThe serum concentration of Simvastatin can be increased when it is combined with Fluconazole.
FluoxetineThe metabolism of Simvastatin can be decreased when combined with Fluoxetine.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Simvastatin.
FluvoxamineThe metabolism of Simvastatin can be decreased when combined with Fluvoxamine.
FosamprenavirThe serum concentration of Simvastatin can be increased when it is combined with Fosamprenavir.
FosaprepitantThe serum concentration of Simvastatin can be increased when it is combined with Fosaprepitant.
FosinoprilThe serum concentration of Simvastatin can be increased when it is combined with Fosinopril.
FosphenytoinThe serum concentration of Simvastatin can be decreased when it is combined with Fosphenytoin.
Fusidic AcidThe serum concentration of Simvastatin can be increased when it is combined with Fusidic Acid.
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Simvastatin.
GeldanamycinThe serum concentration of Simvastatin can be increased when it is combined with Geldanamycin.
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Simvastatin.
GemfibrozilGemfibrozil may increase the myopathic rhabdomyolysis activities of Simvastatin.
GM6001The serum concentration of Simvastatin can be increased when it is combined with GM6001.
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Simvastatin.
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Simvastatin.
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Simvastatin.
HaloperidolThe metabolism of Simvastatin can be decreased when combined with Haloperidol.
HirulogThe serum concentration of Simvastatin can be increased when it is combined with Hirulog.
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Simvastatin.
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Simvastatin.
IdelalisibThe serum concentration of Simvastatin can be increased when it is combined with Idelalisib.
ImatinibThe metabolism of Simvastatin can be decreased when combined with Imatinib.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Simvastatin.
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Simvastatin.
ImipramineThe metabolism of Simvastatin can be decreased when combined with Imipramine.
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Simvastatin.
IndinavirThe serum concentration of Simvastatin can be increased when it is combined with Indinavir.
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Simvastatin.
IrbesartanThe metabolism of Simvastatin can be decreased when combined with Irbesartan.
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Simvastatin.
IsavuconazoniumThe metabolism of Simvastatin can be decreased when combined with Isavuconazonium.
IsoflurophateThe serum concentration of Simvastatin can be increased when it is combined with Isoflurophate.
IsoniazidThe metabolism of Simvastatin can be decreased when combined with Isoniazid.
IsradipineThe metabolism of Simvastatin can be decreased when combined with Isradipine.
ItraconazoleThe serum concentration of Simvastatin can be increased when it is combined with Itraconazole.
IvacaftorThe serum concentration of Simvastatin can be increased when it is combined with Ivacaftor.
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Simvastatin.
IxazomibThe serum concentration of Simvastatin can be increased when it is combined with Ixazomib.
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Simvastatin.
KetoconazoleThe serum concentration of Simvastatin can be increased when it is combined with Ketoconazole.
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Simvastatin.
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Simvastatin.
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Simvastatin.
Lanthanum carbonateThe serum concentration of Lanthanum carbonate can be decreased when it is combined with Simvastatin.
LapatinibThe metabolism of Simvastatin can be decreased when combined with Lapatinib.
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Simvastatin.
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Simvastatin.
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Simvastatin.
LepirudinThe serum concentration of Simvastatin can be increased when it is combined with Lepirudin.
LercanidipineThe serum concentration of Simvastatin can be increased when it is combined with Lercanidipine.
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Simvastatin.
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Simvastatin.
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Simvastatin.
LinagliptinThe serum concentration of Simvastatin can be increased when it is combined with Linagliptin.
LisinoprilThe serum concentration of Simvastatin can be increased when it is combined with Lisinopril.
LomitapideThe serum concentration of Simvastatin can be increased when it is combined with Lomitapide.
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Simvastatin.
LopinavirThe serum concentration of Simvastatin can be increased when it is combined with Lopinavir.
LorcaserinThe metabolism of Simvastatin can be decreased when combined with Lorcaserin.
LosartanThe serum concentration of Losartan can be increased when it is combined with Simvastatin.
LosartanThe metabolism of Simvastatin can be decreased when combined with Losartan.
LovastatinThe metabolism of Simvastatin can be decreased when combined with Lovastatin.
LuliconazoleThe serum concentration of Simvastatin can be increased when it is combined with Luliconazole.
LumacaftorThe serum concentration of Simvastatin can be increased when it is combined with Lumacaftor.
LumefantrineThe metabolism of Simvastatin can be decreased when combined with Lumefantrine.
MagaldrateThe serum concentration of Simvastatin can be decreased when it is combined with Magaldrate.
Magnesium carbonateThe serum concentration of Simvastatin can be decreased when it is combined with Magnesium carbonate.
Magnesium hydroxideThe serum concentration of Simvastatin can be decreased when it is combined with Magnesium hydroxide.
Magnesium oxideThe serum concentration of Simvastatin can be decreased when it is combined with Magnesium oxide.
Magnesium TrisilicateThe serum concentration of Simvastatin can be decreased when it is combined with Magnesium Trisilicate.
MannitolThe serum concentration of Mannitol can be increased when it is combined with Simvastatin.
MethadoneThe metabolism of Simvastatin can be decreased when combined with Methadone.
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Simvastatin.
MethotrimeprazineThe metabolism of Simvastatin can be decreased when combined with Methotrimeprazine.
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Simvastatin.
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Simvastatin.
MetoprololThe metabolism of Simvastatin can be decreased when combined with Metoprolol.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Simvastatin.
MifepristoneThe serum concentration of Simvastatin can be increased when it is combined with Mifepristone.
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Simvastatin.
MirabegronThe metabolism of Simvastatin can be decreased when combined with Mirabegron.
MitotaneThe serum concentration of Simvastatin can be decreased when it is combined with Mitotane.
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Simvastatin.
ModafinilThe serum concentration of Simvastatin can be decreased when it is combined with Modafinil.
MoexiprilThe serum concentration of Simvastatin can be increased when it is combined with Moexipril.
MorphineThe serum concentration of Morphine can be increased when it is combined with Simvastatin.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Simvastatin.
N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-ProlineThe serum concentration of Simvastatin can be increased when it is combined with N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline.
NadololThe serum concentration of Nadolol can be increased when it is combined with Simvastatin.
NafcillinThe serum concentration of Simvastatin can be decreased when it is combined with Nafcillin.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Simvastatin.
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Simvastatin.
NCX 4016The serum concentration of Simvastatin can be increased when it is combined with NCX 4016.
NefazodoneThe serum concentration of Simvastatin can be increased when it is combined with Nefazodone.
NelfinavirThe serum concentration of Simvastatin can be increased when it is combined with Nelfinavir.
NetupitantThe serum concentration of Simvastatin can be increased when it is combined with Netupitant.
NevirapineThe metabolism of Simvastatin can be decreased when combined with Nevirapine.
NiacinThe risk or severity of adverse effects can be increased when Niacin is combined with Simvastatin.
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Simvastatin.
NicardipineThe metabolism of Simvastatin can be decreased when combined with Nicardipine.
NicotinamideThe risk or severity of adverse effects can be increased when Nicotinamide is combined with Simvastatin.
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Simvastatin.
NilotinibThe metabolism of Simvastatin can be decreased when combined with Nilotinib.
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Simvastatin.
NintedanibThe serum concentration of Nintedanib can be decreased when it is combined with Simvastatin.
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Simvastatin.
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Simvastatin.
OlaparibThe metabolism of Simvastatin can be decreased when combined with Olaparib.
OmapatrilatThe serum concentration of Simvastatin can be increased when it is combined with Omapatrilat.
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Simvastatin.
OsimertinibThe serum concentration of Simvastatin can be increased when it is combined with Osimertinib.
OtamixabanThe serum concentration of Simvastatin can be increased when it is combined with Otamixaban.
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Simvastatin.
PalbociclibThe serum concentration of Simvastatin can be increased when it is combined with Palbociclib.
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Simvastatin.
PanobinostatThe metabolism of Simvastatin can be decreased when combined with Panobinostat.
ParoxetineThe metabolism of Simvastatin can be decreased when combined with Paroxetine.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Simvastatin.
Peginterferon alfa-2bThe serum concentration of Simvastatin can be decreased when it is combined with Peginterferon alfa-2b.
PentobarbitalThe metabolism of Simvastatin can be increased when combined with Pentobarbital.
PerindoprilThe serum concentration of Simvastatin can be increased when it is combined with Perindopril.
PhenindioneSimvastatin may increase the anticoagulant activities of Phenindione.
PhenobarbitalThe metabolism of Simvastatin can be increased when combined with Phenobarbital.
PhenobarbitalThe serum concentration of Phenobarbital can be increased when it is combined with Simvastatin.
PhenprocoumonSimvastatin may increase the anticoagulant activities of Phenprocoumon.
PhenytoinThe serum concentration of Simvastatin can be decreased when it is combined with Phenytoin.
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Simvastatin.
PhosphoramidonThe serum concentration of Simvastatin can be increased when it is combined with Phosphoramidon.
PioglitazoneThe metabolism of Simvastatin can be decreased when combined with Pioglitazone.
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Simvastatin.
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Simvastatin.
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Simvastatin.
PosaconazoleThe serum concentration of Simvastatin can be increased when it is combined with Posaconazole.
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Simvastatin.
PrazosinThe serum concentration of Prazosin can be increased when it is combined with Simvastatin.
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Simvastatin.
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Simvastatin.
PrimidoneThe metabolism of Simvastatin can be increased when combined with Primidone.
PrinomastatThe serum concentration of Simvastatin can be increased when it is combined with Prinomastat.
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Simvastatin.
PromazineThe metabolism of Simvastatin can be decreased when combined with Promazine.
PropranololThe serum concentration of Propranolol can be increased when it is combined with Simvastatin.
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Simvastatin.
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Simvastatin.
QuinaprilThe serum concentration of Simvastatin can be increased when it is combined with Quinapril.
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Simvastatin.
QuinidineThe metabolism of Simvastatin can be decreased when combined with Quinidine.
QuinineThe serum concentration of Quinine can be increased when it is combined with Simvastatin.
QuinineThe metabolism of Simvastatin can be decreased when combined with Quinine.
RabeprazoleThe metabolism of Simvastatin can be decreased when combined with Rabeprazole.
RaltegravirRaltegravir may increase the myopathic rhabdomyolysis activities of Simvastatin.
RamiprilThe serum concentration of Simvastatin can be increased when it is combined with Ramipril.
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Simvastatin.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Simvastatin.
RanolazineThe metabolism of Simvastatin can be decreased when combined with Ranolazine.
RemikirenThe serum concentration of Simvastatin can be increased when it is combined with Remikiren.
ReserpineThe serum concentration of Reserpine can be increased when it is combined with Simvastatin.
RifabutinThe metabolism of Simvastatin can be increased when combined with Rifabutin.
RifampicinThe metabolism of Simvastatin can be increased when combined with Rifampicin.
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Simvastatin.
RifapentineThe metabolism of Simvastatin can be increased when combined with Rifapentine.
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Simvastatin.
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Simvastatin.
RitonavirThe serum concentration of Simvastatin can be increased when it is combined with Ritonavir.
RivaroxabanThe serum concentration of Simvastatin can be increased when it is combined with Rivaroxaban.
RolapitantThe metabolism of Simvastatin can be decreased when combined with Rolapitant.
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Simvastatin.
RopiniroleThe metabolism of Simvastatin can be decreased when combined with Ropinirole.
RosiglitazoneThe metabolism of Simvastatin can be decreased when combined with Rosiglitazone.
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Simvastatin.
SaquinavirThe serum concentration of Simvastatin can be increased when it is combined with Saquinavir.
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Simvastatin.
SaxagliptinThe serum concentration of Simvastatin can be increased when it is combined with Saxagliptin.
SecobarbitalThe metabolism of Simvastatin can be increased when combined with Secobarbital.
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Simvastatin.
SertralineThe metabolism of Simvastatin can be decreased when combined with Sertraline.
SildenafilThe metabolism of Simvastatin can be decreased when combined with Sildenafil.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Simvastatin.
SiltuximabThe serum concentration of Simvastatin can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Simvastatin can be increased when it is combined with Simeprevir.
SitagliptinThe serum concentration of Simvastatin can be increased when it is combined with Sitagliptin.
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Simvastatin.
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Simvastatin.
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Simvastatin.
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Simvastatin.
SpiraprilThe serum concentration of Simvastatin can be increased when it is combined with Spirapril.
St. John's WortThe serum concentration of Simvastatin can be decreased when it is combined with St. John's Wort.
StiripentolThe serum concentration of Simvastatin can be increased when it is combined with Stiripentol.
SulfamethoxazoleThe metabolism of Simvastatin can be decreased when combined with Sulfamethoxazole.
SulfisoxazoleThe metabolism of Simvastatin can be decreased when combined with Sulfisoxazole.
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Simvastatin.
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Simvastatin.
TamoxifenThe metabolism of Simvastatin can be decreased when combined with Tamoxifen.
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Simvastatin.
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Simvastatin.
TelaprevirThe serum concentration of Simvastatin can be increased when it is combined with Telaprevir.
TelithromycinThe serum concentration of Simvastatin can be increased when it is combined with Telithromycin.
TemocaprilThe serum concentration of Simvastatin can be increased when it is combined with Temocapril.
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Simvastatin.
TerbinafineThe metabolism of Simvastatin can be decreased when combined with Terbinafine.
TeriflunomideThe serum concentration of Simvastatin can be increased when it is combined with Teriflunomide.
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Simvastatin.
ThioridazineThe metabolism of Simvastatin can be decreased when combined with Thioridazine.
ThiorphanThe serum concentration of Simvastatin can be increased when it is combined with Thiorphan.
TicagrelorThe serum concentration of Simvastatin can be increased when it is combined with Ticagrelor.
TiclopidineThe metabolism of Simvastatin can be decreased when combined with Ticlopidine.
TimololThe serum concentration of Timolol can be increased when it is combined with Simvastatin.
TipranavirThe serum concentration of Simvastatin can be increased when it is combined with Tipranavir.
TocilizumabThe serum concentration of Simvastatin can be decreased when it is combined with Tocilizumab.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Simvastatin.
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Simvastatin.
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Simvastatin.
TrabectedinSimvastatin may increase the myopathic rhabdomyolysis activities of Trabectedin.
TrandolaprilThe serum concentration of Simvastatin can be increased when it is combined with Trandolapril.
TranylcypromineThe metabolism of Simvastatin can be decreased when combined with Tranylcypromine.
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Simvastatin.
TrimethoprimThe metabolism of Simvastatin can be decreased when combined with Trimethoprim.
UbenimexThe serum concentration of Simvastatin can be increased when it is combined with Ubenimex.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Simvastatin.
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Simvastatin.
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Simvastatin.
VenlafaxineThe metabolism of Simvastatin can be decreased when combined with Venlafaxine.
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Simvastatin.
VerapamilThe metabolism of Simvastatin can be decreased when combined with Verapamil.
VerapamilThe serum concentration of Verapamil can be increased when it is combined with Simvastatin.
VildagliptinThe serum concentration of Simvastatin can be increased when it is combined with Vildagliptin.
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Simvastatin.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Simvastatin.
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Simvastatin.
VoriconazoleThe serum concentration of Simvastatin can be increased when it is combined with Voriconazole.
WarfarinSimvastatin may increase the anticoagulant activities of Warfarin.
XimelagatranThe serum concentration of Simvastatin can be increased when it is combined with Ximelagatran.
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Simvastatin.
ZiprasidoneThe metabolism of Simvastatin can be decreased when combined with Ziprasidone.
Food Interactions
  • Avoid alcohol.
  • Avoid drastic changes in dietary habit.
  • Avoid taking with grapefruit juice.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Nadph binding
Specific Function:
Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
Gene Name:
HMGCR
Uniprot ID:
P04035
Molecular Weight:
97475.155 Da
References
  1. Cenedella RJ, Kuszak JR, Al-Ghoul KJ, Qin S, Sexton PS: Discordant expression of the sterol pathway in lens underlies simvastatin-induced cataracts in Chbb: Thom rats. J Lipid Res. 2003 Jan;44(1):198-211. [PubMed:12518039 ]
  2. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  3. Kocarek TA, Dahn MS, Cai H, Strom SC, Mercer-Haines NA: Regulation of CYP2B6 and CYP3A expression by hydroxymethylglutaryl coenzyme A inhibitors in primary cultured human hepatocytes. Drug Metab Dispos. 2002 Dec;30(12):1400-5. [PubMed:12433810 ]
  4. Liu L, Zhang R, Zhao JJ, Rogers JD, Hsieh JY, Fang W, Matuszewski BK, Dobrinska MR: Determination of simvastatin-derived HMG-CoA reductase inhibitors in biomatrices using an automated enzyme inhibition assay with radioactivity detection. J Pharm Biomed Anal. 2003 Apr 24;32(1):107-23. [PubMed:12852453 ]
  5. Pappu AS, Bacon SP, Illingworth DR: Residual effects of lovastatin and simvastatin on urinary mevalonate excretions in patients with familial hypercholesterolemia. J Lab Clin Med. 2003 Apr;141(4):250-6. [PubMed:12677170 ]
  6. Stoebner PE, Michot C, Ligeron C, Durand L, Meynadier J, Meunier L: [Simvastatin-induced lichen planus pemphigoides]. Ann Dermatol Venereol. 2003 Feb;130(2 Pt 1):187-90. [PubMed:12671581 ]
Kind
Protein
Organism
Human
Pharmacological action
no
Actions
other
General Function:
Protein kinase binding
Specific Function:
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is a...
Gene Name:
ITGB2
Uniprot ID:
P05107
Molecular Weight:
84781.08 Da
References
  1. Fujii T, Masuyama K, Kawashima K: Simvastatin regulates non-neuronal cholinergic activity in T lymphocytes via CD11a-mediated pathways. J Neuroimmunol. 2006 Oct;179(1-2):101-7. Epub 2006 Jul 10. [PubMed:16828882 ]
  2. Fujii T, Takada-Takatori Y, Kawashima K: Roles played by lymphocyte function-associated antigen-1 in the regulation of lymphocytic cholinergic activity. Life Sci. 2007 May 30;80(24-25):2320-4. Epub 2007 Jan 17. [PubMed:17289088 ]
  3. Katano H, Pesnicak L, Cohen JI: Simvastatin induces apoptosis of Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines and delays development of EBV lymphomas. Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4960-5. Epub 2004 Mar 23. [PubMed:15041742 ]
  4. Takahashi HK, Mori S, Iwagaki H, Yoshino T, Tanaka N, Nishibori M: Simvastatin induces interleukin-18 production in human peripheral blood mononuclear cells. Clin Immunol. 2005 Sep;116(3):211-6. [PubMed:15936988 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitorinducer
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Neuvonen PJ, Niemi M, Backman JT: Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance. Clin Pharmacol Ther. 2006 Dec;80(6):565-81. [PubMed:17178259 ]
  2. Cohen LH, van Leeuwen RE, van Thiel GC, van Pelt JF, Yap SH: Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos. 2000 Dec;21(9):353-64. [PubMed:11523064 ]
  3. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  4. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  5. Galetin A, Clarke SE, Houston JB: Quinidine and haloperidol as modifiers of CYP3A4 activity: multisite kinetic model approach. Drug Metab Dispos. 2002 Dec;30(12):1512-22. [PubMed:12433827 ]
  6. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
  7. Website [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Neuvonen PJ, Niemi M, Backman JT: Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance. Clin Pharmacol Ther. 2006 Dec;80(6):565-81. [PubMed:17178259 ]
  2. Tornio A, Pasanen MK, Laitila J, Neuvonen PJ, Backman JT: Comparison of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) as inhibitors of cytochrome P450 2C8. Basic Clin Pharmacol Toxicol. 2005 Aug;97(2):104-8. [PubMed:15998357 ]
  3. Walsky RL, Gaman EA, Obach RS: Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78. [PubMed:15601807 ]
  4. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitorinducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Cohen LH, van Leeuwen RE, van Thiel GC, van Pelt JF, Yap SH: Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos. 2000 Dec;21(9):353-64. [PubMed:11523064 ]
  2. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  3. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Cohen LH, van Leeuwen RE, van Thiel GC, van Pelt JF, Yap SH: Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos. 2000 Dec;21(9):353-64. [PubMed:11523064 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid binding
Specific Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naph...
Gene Name:
UGT1A1
Uniprot ID:
P22309
Molecular Weight:
59590.91 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Retinoic acid binding
Specific Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.
Gene Name:
UGT1A3
Uniprot ID:
P35503
Molecular Weight:
60337.835 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Glucuronosyltransferase activity
Specific Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites. Is also active with androsterone, hyodeoxycholic acid and tetrachlorocatechol...
Gene Name:
UGT2B7
Uniprot ID:
P16662
Molecular Weight:
60694.12 Da

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Wang E, Casciano CN, Clement RP, Johnson WW: HMG-CoA reductase inhibitors (statins) characterized as direct inhibitors of P-glycoprotein. Pharm Res. 2001 Jun;18(6):800-6. [PubMed:11474784 ]
  2. Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. [PubMed:11716514 ]
  3. Hochman JH, Pudvah N, Qiu J, Yamazaki M, Tang C, Lin JH, Prueksaritanont T: Interactions of human P-glycoprotein with simvastatin, simvastatin acid, and atorvastatin. Pharm Res. 2004 Sep;21(9):1686-91. [PubMed:15497697 ]
  4. Sieczkowski E, Lehner C, Ambros PF, Hohenegger M: Double impact on p-glycoprotein by statins enhances doxorubicin cytotoxicity in human neuroblastoma cells. Int J Cancer. 2010 May 1;126(9):2025-35. doi: 10.1002/ijc.24885. [PubMed:19739078 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.
Gene Name:
SLCO1A2
Uniprot ID:
P46721
Molecular Weight:
74144.105 Da
References
  1. Hsiang B, Zhu Y, Wang Z, Wu Y, Sasseville V, Yang WP, Kirchgessner TG: A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J Biol Chem. 1999 Dec 24;274(52):37161-8. [PubMed:10601278 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.
Gene Name:
SLCO1B1
Uniprot ID:
Q9Y6L6
Molecular Weight:
76447.99 Da
References
  1. Hsiang B, Zhu Y, Wang Z, Wu Y, Sasseville V, Yang WP, Kirchgessner TG: A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J Biol Chem. 1999 Dec 24;274(52):37161-8. [PubMed:10601278 ]
  2. Kameyama Y, Yamashita K, Kobayashi K, Hosokawa M, Chiba K: Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1*5, SLCO1B1*15 and SLCO1B1*15+C1007G, by using transient expression systems of HeLa and HEK293 cells. Pharmacogenet Genomics. 2005 Jul;15(7):513-22. [PubMed:15970799 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Organic anion transmembrane transporter activity
Specific Function:
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
Gene Name:
ABCC2
Uniprot ID:
Q92887
Molecular Weight:
174205.64 Da
References
  1. Becker ML, Elens LL, Visser LE, Hofman A, Uitterlinden AG, van Schaik RH, Stricker BH: Genetic variation in the ABCC2 gene is associated with dose decreases or switches to other cholesterol-lowering drugs during simvastatin and atorvastatin therapy. Pharmacogenomics J. 2013 Jun;13(3):251-6. doi: 10.1038/tpj.2011.59. Epub 2011 Dec 20. [PubMed:22186618 ]
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Drug created on June 13, 2005 07:24 / Updated on September 29, 2016 03:39