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Identification
NameSimvastatin
Accession NumberDB00641  (APRD00104)
TypeSmall Molecule
GroupsApproved
Description

Simvastatin is a lipid-lowering agent that is derived synthetically from the fermentation of Aspergillus terreus. It is a potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (hydroxymethylglutaryl COA reductases), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL receptors, it increases breakdown of LDL cholesterol. [PubChem]

Structure
Thumb
Synonyms
2,2-Dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8ar)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one
MK-733
Simvastatin
Simvastatina
Simvastatine
Simvastatinum
Synvinolin
Zocor
External Identifiers
  • MK 733
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Act Simvastatintablet20 mgoralActavis Pharma Company2003-09-26Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Act Simvastatintablet10 mgoralActavis Pharma Company2003-09-26Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Act Simvastatintablet5 mgoralActavis Pharma Company2003-09-26Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Act Simvastatintablet80 mgoralActavis Pharma Company2003-09-26Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Act Simvastatintablet40 mgoralActavis Pharma Company2003-09-26Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Auro-simvastatintablet20 mgoralAuro Pharma Inc2013-07-08Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Auro-simvastatintablet5 mgoralAuro Pharma Inc2013-07-08Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Auro-simvastatintablet10 mgoralAuro Pharma Inc2013-07-08Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Auro-simvastatintablet80 mgoralAuro Pharma Inc2013-07-08Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Auro-simvastatintablet40 mgoralAuro Pharma Inc2013-07-08Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ava-simvastatintablet20 mgoralAvanstra Inc2011-10-112014-08-21Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ava-simvastatintablet10 mgoralAvanstra Inc2011-10-112014-08-21Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ava-simvastatintablet5 mgoralAvanstra Inc2011-10-112014-08-21Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ava-simvastatintablet80 mgoralAvanstra Inc2011-10-112014-08-21Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ava-simvastatintablet40 mgoralAvanstra Inc2011-10-112014-08-21Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Bci Simvastatintablet20 mgoralBaker Cummins IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Bci Simvastatintablet80 mgoralBaker Cummins IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Bci Simvastatintablet10 mgoralBaker Cummins IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Bci Simvastatintablet40 mgoralBaker Cummins IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Bci Simvastatintablet5 mgoralBaker Cummins IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Dom-simvastatintablet20 mgoralDominion Pharmacal2004-08-11Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Dom-simvastatintablet80 mgoralDominion Pharmacal2006-08-02Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Dom-simvastatintablet10 mgoralDominion Pharmacal2006-08-02Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Dom-simvastatintablet5 mgoralDominion Pharmacal2006-08-02Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Dom-simvastatintablet80 mgoralDominion Pharmacal2004-08-11Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Dom-simvastatintablet40 mgoralDominion Pharmacal2006-08-02Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Dom-simvastatintablet10 mgoralDominion Pharmacal2004-08-11Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Dom-simvastatintablet40 mgoralDominion Pharmacal2004-08-11Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Dom-simvastatintablet20 mgoralDominion Pharmacal2006-08-02Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Dom-simvastatintablet5 mgoralDominion Pharmacal2004-08-11Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ipg-simvastatintablet80 mgoralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ipg-simvastatintablet40 mgoralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ipg-simvastatintablet20 mgoralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ipg-simvastatintablet10 mgoralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ipg-simvastatintablet5 mgoralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Jamp-simvastatintablet40 mgoralJamp Pharma Corporation2012-01-09Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Jamp-simvastatintablet20 mgoralJamp Pharma Corporation2012-01-09Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Jamp-simvastatintablet80 mgoralJamp Pharma Corporation2010-03-122013-07-08Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Jamp-simvastatintablet10 mgoralJamp Pharma Corporation2012-01-09Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Jamp-simvastatintablet40 mgoralJamp Pharma Corporation2010-03-122013-07-08Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Jamp-simvastatintablet5 mgoralJamp Pharma Corporation2012-01-09Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Jamp-simvastatintablet20 mgoralJamp Pharma Corporation2010-03-122013-07-08Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Jamp-simvastatintablet10 mgoralJamp Pharma Corporation2010-03-122013-07-08Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Jamp-simvastatintablet5 mgoralJamp Pharma Corporation2010-03-232013-07-08Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Jamp-simvastatintablet80 mgoralJamp Pharma Corporation2012-01-09Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mar-simvastatintablet10 mgoralMarcan Pharmaceuticals Inc2012-12-20Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mar-simvastatintablet80 mgoralMarcan Pharmaceuticals Inc2012-12-20Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mar-simvastatintablet40 mgoralMarcan Pharmaceuticals Inc2012-12-20Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mar-simvastatintablet5 mgoralMarcan Pharmaceuticals Inc2012-12-20Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mar-simvastatintablet20 mgoralMarcan Pharmaceuticals Inc2012-12-20Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mint-simvastatintablet40 mgoralMint Pharmaceuticals Inc2011-09-07Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mint-simvastatintablet20 mgoralMint Pharmaceuticals Inc2011-09-07Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mint-simvastatintablet10 mgoralMint Pharmaceuticals Inc2011-09-07Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mint-simvastatintablet5 mgoralMint Pharmaceuticals Inc2011-09-07Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mint-simvastatintablet80 mgoralMint Pharmaceuticals Inc2011-09-07Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mylan-simvastatintablet20 mgoralMylan Pharmaceuticals Ulc2003-01-15Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mylan-simvastatintablet80 mgoralMylan Pharmaceuticals Ulc2003-01-15Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mylan-simvastatintablet40 mgoralMylan Pharmaceuticals Ulc2003-01-15Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mylan-simvastatintablet10 mgoralMylan Pharmaceuticals Ulc2003-01-15Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mylan-simvastatintablet5 mgoralMylan Pharmaceuticals Ulc2003-01-15Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ntp-simvastatintablet80 mgoralNt Pharma Canada LtdNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ntp-simvastatintablet40 mgoralNt Pharma Canada LtdNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ntp-simvastatintablet20 mgoralNt Pharma Canada LtdNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ntp-simvastatintablet10 mgoralNt Pharma Canada LtdNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ntp-simvastatintablet5 mgoralNt Pharma Canada LtdNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nu-simvastatin Tabletstablet80 mgoralNu Pharm Inc2004-06-212012-09-04Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nu-simvastatin Tabletstablet40 mgoralNu Pharm Inc2004-06-212012-09-04Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nu-simvastatin Tabletstablet20 mgoralNu Pharm Inc2004-06-212012-09-04Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nu-simvastatin Tabletstablet10 mgoralNu Pharm Inc2004-06-212012-09-04Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nu-simvastatin Tabletstablet5 mgoralNu Pharm Inc2004-06-212012-09-04Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PHL-simvastatintablet80 mgoralPharmel Inc2004-08-11Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PHL-simvastatintablet40 mgoralPharmel Inc2004-08-11Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PHL-simvastatintablet80 mgoralPharmel Inc2006-07-21Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PHL-simvastatintablet20 mgoralPharmel Inc2004-08-11Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PHL-simvastatintablet40 mgoralPharmel Inc2006-07-21Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PHL-simvastatintablet10 mgoralPharmel Inc2004-08-11Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PHL-simvastatintablet20 mgoralPharmel Inc2006-07-21Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PHL-simvastatintablet5 mgoralPharmel Inc2004-08-11Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PHL-simvastatintablet10 mgoralPharmel Inc2006-07-21Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PHL-simvastatintablet5 mgoralPharmel Inc2006-07-21Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-simvastatintablet80 mgoralPharmascience Inc2005-11-03Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-simvastatintablet20 mgoralPharmascience Inc2004-05-07Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-simvastatintablet40 mgoralPharmascience Inc2005-11-03Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-simvastatintablet10 mgoralPharmascience Inc2004-05-07Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-simvastatintablet20 mgoralPharmascience Inc2005-11-03Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-simvastatintablet5 mgoralPharmascience Inc2004-05-07Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-simvastatintablet10 mgoralPharmascience Inc2005-11-03Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-simvastatintablet5 mgoralPharmascience Inc2005-11-03Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-simvastatintablet80 mgoralPharmascience Inc2004-05-07Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-simvastatintablet40 mgoralPharmascience Inc2004-05-07Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Q-simvastatintablet10 mgoralQd Pharmaceuticals Ulc2012-02-032015-08-21Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Q-simvastatintablet80 mgoralQd Pharmaceuticals UlcNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Q-simvastatintablet40 mgoralQd Pharmaceuticals Ulc2012-02-032015-08-21Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Q-simvastatintablet5 mgoralQd Pharmaceuticals UlcNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Q-simvastatintablet20 mgoralQd Pharmaceuticals Ulc2012-02-032015-08-21Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ran-simvastatintablet10 mgoralRanbaxy Pharmaceuticals Canada Inc.2009-07-20Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ran-simvastatintablet5 mgoralRanbaxy Pharmaceuticals Canada Inc.2009-07-20Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ran-simvastatintablet80 mgoralRanbaxy Pharmaceuticals Canada Inc.2009-07-20Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ran-simvastatintablet40 mgoralRanbaxy Pharmaceuticals Canada Inc.2009-07-20Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ran-simvastatintablet20 mgoralRanbaxy Pharmaceuticals Canada Inc.2009-07-20Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ratio-simvastatintablet80 mgoralRatiopharm Inc Division Of Teva Canada Limited2003-10-272014-09-19Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ratio-simvastatintablet40 mgoralRatiopharm Inc Division Of Teva Canada Limited2003-10-272014-09-19Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ratio-simvastatintablet20 mgoralRatiopharm Inc Division Of Teva Canada Limited2003-10-272014-09-19Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ratio-simvastatintablet10 mgoralRatiopharm Inc Division Of Teva Canada Limited2003-10-272014-09-19Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ratio-simvastatintablet5 mgoralRatiopharm Inc Division Of Teva Canada Limited2003-10-272014-09-19Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Riva-simvastatintablet80 mgoralLaboratoire Riva Inc2003-03-10Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Riva-simvastatintablet40 mgoralLaboratoire Riva Inc2003-03-10Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Riva-simvastatintablet20 mgoralLaboratoire Riva Inc2003-03-10Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Riva-simvastatintablet10 mgoralLaboratoire Riva Inc2003-03-10Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Riva-simvastatintablet5 mgoralLaboratoire Riva Inc2003-03-10Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sandoz Simvastatintablet5 mgoralSandoz Canada Incorporated2003-10-29Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sandoz Simvastatintablet80 mgoralSandoz Canada Incorporated2003-10-29Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sandoz Simvastatintablet40 mgoralSandoz Canada Incorporated2003-10-29Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sandoz Simvastatintablet20 mgoralSandoz Canada Incorporated2004-06-23Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sandoz Simvastatintablet10 mgoralSandoz Canada Incorporated2003-10-29Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Septa-simvastatintablet80 mgoralSepta Pharmaceuticals IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Septa-simvastatintablet10 mgoralSepta Pharmaceuticals IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Septa-simvastatintablet5 mgoralSepta Pharmaceuticals IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Septa-simvastatintablet40 mgoralSepta Pharmaceuticals IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Septa-simvastatintablet20 mgoralSepta Pharmaceuticals IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatintablet5 mgoralMeliapharm Inc2010-06-112014-06-25Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatintablet10 mgoralBentec Pharma Inc2013-03-012015-12-15Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatintablet20 mgoralBentec Pharma IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatintablet80 mgoralFrosst A Division Of Merck Canada IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatintablet5 mgoralBentec Pharma IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatintablet40 mgoralFrosst A Division Of Merck Canada IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatintablet80 mgoralSivem Pharmaceuticals Ulc2012-06-11Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatintablet80 mgoralSanis Health Inc2009-10-22Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatintablet40 mgoralSivem Pharmaceuticals Ulc2012-06-11Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatintablet80 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatintablet20 mgoralFrosst A Division Of Merck Canada IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatintablet40 mgoralSanis Health Inc2009-10-22Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatintablet80 mgoralMeliapharm Inc2010-06-112014-06-25Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatintablet10 mgoralFrosst A Division Of Merck Canada IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatintablet20 mgoralSivem Pharmaceuticals Ulc2012-06-12Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatintablet40 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatintablet40 mgoralMeliapharm Inc2010-06-112014-06-25Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatintablet20 mgoralSanis Health Inc2009-10-22Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatintablet5 mgoralFrosst A Division Of Merck Canada IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatintablet10 mgoralSivem Pharmaceuticals Ulc2012-06-11Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatintablet20 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatintablet20 mgoralMeliapharm Inc2010-06-112014-06-25Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatintablet10 mgoralSanis Health Inc2009-10-22Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatintablet80 mgoralBentec Pharma IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatintablet5 mgoralSivem Pharmaceuticals Ulc2012-06-11Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatintablet10 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatintablet10 mgoralMeliapharm Inc2010-06-112014-06-25Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatintablet5 mgoralSanis Health Inc2009-10-22Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatintablet40 mgoralBentec Pharma IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatintablet5 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatin Tabletstablet80 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatin Tabletstablet40 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatin Tabletstablet20 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatin Tabletstablet10 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatin Tabletstablet5 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatin Tablets 10mgtablet10 mgoralPrempharm Inc2003-09-032005-08-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatin Tablets 20mgtablet20 mgoralPrempharm Inc2003-09-032005-08-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatin Tablets 40mgtablet40 mgoralPrempharm Inc2003-09-032005-08-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatin Tablets 5mgtablet5 mgoralPrempharm Inc2003-09-032005-08-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatin Tablets 80mgtablet80 mgoralPrempharm Inc2003-09-032005-08-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatin-10tablet10 mgoralPro Doc Limitee2003-04-10Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatin-20tablet20 mgoralPro Doc Limitee2003-04-10Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatin-40tablet40 mgoralPro Doc Limitee2003-04-10Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatin-80tablet80 mgoralPro Doc Limitee2009-06-15Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatin-odantablet80 mgoralOdan Laboratories Ltd2012-02-142014-11-17Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatin-odantablet40 mgoralOdan Laboratories Ltd2012-02-142014-11-12Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatin-odantablet20 mgoralOdan Laboratories Ltd2012-02-142014-11-12Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatin-odantablet10 mgoralOdan Laboratories Ltd2012-02-142014-11-12Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatin-odantablet5 mgoralOdan Laboratories Ltd2012-02-142014-11-12Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Taro-simvastatintablet40 mgoralTaro Pharmaceuticals Inc2005-08-102014-04-01Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Taro-simvastatintablet20 mgoralTaro Pharmaceuticals Inc2005-08-102014-04-01Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Taro-simvastatintablet10 mgoralTaro Pharmaceuticals Inc2005-08-102014-04-01Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Teva-simvastatintablet5 mgoralTeva Canada Limited2004-03-22Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Teva-simvastatintablet80 mgoralTeva Canada Limited2004-03-22Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Teva-simvastatintablet40 mgoralTeva Canada Limited2004-03-22Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Teva-simvastatintablet20 mgoralTeva Canada Limited2004-03-22Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Teva-simvastatintablet10 mgoralTeva Canada Limited2004-03-22Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Zocortablet, film coated80 mg/1oralMerck Sharp & Dohme Corp.1991-12-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Zocortablet5 mgoralMerck Canada Inc1991-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Zocortablet10 mgoralMerck Canada Inc1990-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Zocortablet, film coated20 mg/1oralLake Erie Medical Surgical & Supply DBA Quality Care Products LLC2011-08-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Zocortablet, film coated40 mg/1oralMerck Sharp & Dohme Corp.1991-12-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Zocortablet, film coated20 mg/1oralMerck Sharp & Dohme Corp.1991-12-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Zocortablet, film coated10 mg/1oralMerck Sharp & Dohme Corp.1991-12-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Zocortablet80 mgoralMerck Canada Inc1999-07-212014-05-06Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Zocortablet40 mgoralMerck Canada Inc1996-08-14Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Zocortablet, film coated5 mg/1oralMerck Sharp & Dohme Corp.1991-12-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Zocortablet20 mgoralMerck Canada Inc1994-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Zym-simvastatintablet40 mgoralZymcan Pharmaceuticals Inc2009-02-262014-06-16Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Zym-simvastatintablet20 mgoralZymcan Pharmaceuticals Inc2009-02-262014-06-16Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Zym-simvastatintablet10 mgoralZymcan Pharmaceuticals Inc2009-02-262014-06-16Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Zym-simvastatintablet5 mgoralZymcan Pharmaceuticals Inc2009-02-262014-06-16Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Zym-simvastatintablet80 mgoralZymcan Pharmaceuticals Inc2009-02-262014-06-16Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-simvastatintablet20 mgoralApotex Inc2002-12-20Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Apo-simvastatintablet10 mgoralApotex Inc2002-12-20Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Apo-simvastatintablet5 mgoralApotex Inc2002-12-20Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Apo-simvastatintablet80 mgoralApotex Inc2002-12-20Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Apo-simvastatintablet40 mgoralApotex Inc2002-12-20Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Simvastatintablet, film coated10 mg/1oralAphena Pharma Solutions Tennessee, Llc2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralMajor Pharmaceuticals2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralAurobindo Pharma Limited2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated80 mg/1oralBlu Pharmaceuticals, LLC2008-02-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralNorth Star Rx Llc2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated5 mg/1oralGen Source Rx2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralCardinal Health2008-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralState of Florida DOH Central Pharmacy2014-11-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralLake Erie Medical DBA Quality Care Products LLC2008-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralAv Pak2014-12-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralPd Rx Pharmaceuticals, Inc.2011-06-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralProficient Rx LP2008-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated5 mg/1oralTeva Pharmaceuticals USA Inc2006-06-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralLupin Pharmaceuticals, Inc.2007-06-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralPreferred Pharmaceuticals, Inc.2012-02-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2012-11-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralContract Pharmacy Services Pa2010-06-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralCamber Pharmaceuticals, Inc.2014-12-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated5 mg/1oralAccord Healthcare, Inc.2013-09-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet40 mg/1oralCardinal Health2011-05-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet10 mg/1oralPhysicians Total Care, Inc.2007-02-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet10 mg/1oralMicro Labs Limited2013-06-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated80 mg/1oralUnit Dose Services2008-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet10 mg/1oralClinical Solutions Wholesale2007-06-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralbryant ranch prepack2008-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralZydus Pharmaceuticals (USA) Inc.2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralMc Kesson Contract Packaging2011-08-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralBiocon Limited2015-12-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet20 mg/1oralREMEDYREPACK INC.2011-07-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralAurolife Pharma LLC2009-11-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralCardinal Health2011-10-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralDr. Reddy's Laboratories Limited2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralAphena Pharma Solutions Tennessee, Inc.2011-10-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralMylan Institutional Inc.2006-07-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralDIRECT RX2014-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2008-03-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2012-06-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet80 mg/1oralLegacy Pharmaceutical Packaging, Llc2007-06-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated5 mg/1oralAurobindo Pharma Limited2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-11-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet80 mg/1oralCobalt Laboratories Inc.2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralLupin Pharmaceuticals, Inc.2015-12-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralRx Change Co.2008-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralBlu Pharmaceuticals, LLC2008-02-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralH.J. Harkins Company, Inc.2008-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralCardinal Health2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralInternational Laboratories, Inc.2010-11-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet5 mg/1oralMicro Labs Limited2013-06-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralUnit Dose Services2008-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated80 mg/1oralClinical Solutions Wholesale2008-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated80 mg/1oralRanbaxy Pharmaceuticals Inc.2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralZydus Pharmaceuticals (USA) Inc.2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralMc Kesson Contract Packaging2011-10-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralBiocon Limited2015-12-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet40 mg/1oralREMEDYREPACK INC.2011-07-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralAurolife Pharma LLC2009-11-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated5 mg/1oralContract Pharmacy Services Pa2010-08-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated5 mg/1oralCamber Pharmaceuticals, Inc.2014-12-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated80 mg/1oralAccord Healthcare, Inc.2008-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated5 mg/1oralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralCardinal Health2011-10-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralDr. Reddy's Laboratories Limited2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated80 mg/1oralAphena Pharma Solutions Tennessee, Inc.2011-10-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralMylan Institutional Inc.2006-07-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralREMEDYREPACK INC.2015-03-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2008-03-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet40 mg/1oralLegacy Pharmaceutical Packaging, Llc2007-06-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated80 mg/1oralCadila Healthcare Limited2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralREMEDYREPACK INC.2013-05-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet40 mg/1oralCobalt Laboratories Inc.2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated5 mg/1oralCarilion Materials Management2006-06-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralAidarex Pharmaceuticals LLC2008-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated5 mg/1oralBlu Pharmaceuticals, LLC2008-02-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralH.J. Harkins Company, Inc.2008-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated80 mg/1oralCardinal Health2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralInternational Laboratories, Inc.2010-11-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated80 mg/1oralRebel Distributors Corp2008-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralUnit Dose Services2008-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralClinical Solutions Wholesale2008-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralRanbaxy Pharmaceuticals Inc.2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated5 mg/1oralKAISER FOUNDATION HOSPITALS2013-02-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralZydus Pharmaceuticals (USA) Inc.2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralLife Line Home Care Services, Inc.2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralBiocon Limited2015-12-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet40 mg/1oralREMEDYREPACK INC.2011-04-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated5 mg/1oralAurolife Pharma LLC2009-11-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralContract Pharmacy Services Pa2010-06-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated80 mg/1oralBlu Pharmceuticals Llc2011-10-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralAccord Healthcare, Inc.2008-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated5 mg/1oralDr. Reddy's Laboratories Limited2007-08-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralPd Rx Pharmaceuticals, Inc.2015-08-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralMylan Institutional Inc.2006-07-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralREMEDYREPACK INC.2015-03-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2008-03-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet20 mg/1oralLegacy Pharmaceutical Packaging, Llc2007-06-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralCadila Healthcare Limited2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet40 mg/1oralREMEDYREPACK INC.2011-09-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet20 mg/1oralCobalt Laboratories Inc.2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated80 mg/1oralAmerican Health Packaging2011-05-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralAidarex Pharmaceuticals LLC2008-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet80 mg/1oralRebel Distributors Corp2007-05-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralCardinal Health2011-10-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralInternational Laboratories, Inc.2010-11-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralRebel Distributors Corp2008-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralUnit Dose Services2008-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralClinical Solutions Wholesale2008-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralRanbaxy Pharmaceuticals Inc.2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated80 mg/1oralTeva Pharmaceuticals USA Inc2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated5 mg/1oralZydus Pharmaceuticals (USA) Inc.2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralPreferred Pharmaceuticals, Inc.2012-02-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated5 mg/1oralBiocon Limited2015-12-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet20 mg/1oralREMEDYREPACK INC.2010-09-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralBlenheim Pharmacal, Inc.2015-03-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralMed Vantx, Inc.2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralBlu Pharmceuticals Llc2011-10-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralAccord Healthcare, Inc.2008-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated80 mg/1oralGen Source Rx2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralCardinal Health2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated80 mg/1oralIngenus Pharmaceuticals, LLC2012-01-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralSt Marys Medical Park Pharmacy2014-04-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated5 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2008-03-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated80 mg/1oralLegacy Pharmaceutical Packaging2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated5 mg/1oralH.J. Harkins Company, Inc.2007-08-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralCadila Healthcare Limited2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet20 mg/1oralREMEDYREPACK INC.2011-12-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet10 mg/1oralCobalt Laboratories Inc.2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralAmerican Health Packaging2011-05-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralAidarex Pharmaceuticals LLC2008-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet40 mg/1oralRebel Distributors Corp2008-07-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralCardinal Health2013-04-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet5 mg/1oralPhysicians Total Care, Inc.2009-09-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated80 mg/1oralPd Rx Pharmaceuticals, Inc.2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralUnit Dose Services2008-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralLake Erie Medical DBA Quality Care Products LLC2012-03-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralRanbaxy Pharmaceuticals Inc.2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralTeva Pharmaceuticals USA Inc2006-06-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated5 mg/1oralLupin Pharmaceuticals, Inc.2009-07-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralPreferred Pharmaceuticals, Inc.2012-02-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralReady Meds2008-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralSafecor Health, LLC2014-09-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated80 mg/1oralBlenheim Pharmacal, Inc.2015-03-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralMed Vantx, Inc.2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralBlu Pharmceuticals Llc2011-10-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralAccord Healthcare, Inc.2008-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralGen Source Rx2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralCardinal Health2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralInternational Labs, Inc.2013-09-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralRebel Distributors Corp2008-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated80 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet40 mg/1oralLegacy Pharmaceutical Packaging2010-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralMc Kesson Contract Packaging2013-02-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralCadila Healthcare Limited2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralREMEDYREPACK INC.2013-05-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet5 mg/1oralCobalt Laboratories Inc.2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralAmerican Health Packaging2011-05-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated80 mg/1oralCamber Pharmaceuticals, Inc.2014-12-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet20 mg/1oralRebel Distributors Corp2008-07-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralCardinal Health2013-04-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet80 mg/1oralPhysicians Total Care, Inc.2007-05-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet80 mg/1oralMicro Labs Limited2013-06-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralIngenus Pharmaceuticals, LLC2012-01-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated80 mg/1oralSt Marys Medical Park Pharmacy2008-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated80 mg/1oralbryant ranch prepack2008-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralTeva Pharmaceuticals USA Inc2006-06-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated80 mg/1oralLupin Pharmaceuticals, Inc.2007-06-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralPreferred Pharmaceuticals, Inc.2012-03-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralReady Meds2008-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated5 mg/1oralAphena Pharma Solutions Tennessee, Llc2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralBlenheim Pharmacal, Inc.2015-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralMed Vantx, Inc.2006-06-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralBlu Pharmceuticals Llc2011-10-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated80 mg/1oralNorth Star Rx Llc2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralGen Source Rx2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralCardinal Health2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralInternational Labs, Inc.2013-09-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralRebel Distributors Corp2008-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated80 mg/1oralAv Pak2014-12-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralPd Rx Pharmaceuticals, Inc.2011-06-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated5 mg/1oralRanbaxy Pharmaceuticals Inc.2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet40 mg/1oralREMEDYREPACK INC.2011-08-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated80 mg/1oralAurolife Pharma LLC2009-11-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralAmerican Health Packaging2011-05-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralCamber Pharmaceuticals, Inc.2014-12-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet10 mg/1oralRebel Distributors Corp2007-02-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated5 mg/1oralCardinal Health2006-06-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet40 mg/1oralPhysicians Total Care, Inc.2008-07-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet40 mg/1oralMicro Labs Limited2013-06-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralIngenus Pharmaceuticals, LLC2012-01-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralSt Marys Medical Park Pharmacy2008-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralbryant ranch prepack2008-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2007-08-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet20 mg/1oralLegacy Pharmaceutical Packaging2010-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralMc Kesson Contract Packaging2012-10-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated5 mg/1oralCadila Healthcare Limited2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralLupin Pharmaceuticals, Inc.2007-06-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralLake Erie Medical DBA Quality Care Products LLC2008-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralBlu Pharmaceuticals, LLC2008-02-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated5 mg/1oralCardinal Health2011-10-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated80 mg/1oralDr. Reddy's Laboratories Limited2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated80 mg/1oralAphena Pharma Solutions Tennessee, Llc2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated80 mg/1oralREMEDYREPACK INC.2013-02-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralProficient Rx LP2008-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2012-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralMajor Pharmaceuticals2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated80 mg/1oralPreferred Pharmaceuticals, Inc.2014-10-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralAurobindo Pharma Limited2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralAv Pak2014-12-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralNorth Star Rx Llc2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralAphena Pharma Solutions Tennessee, Llc2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralBlenheim Pharmacal, Inc.2014-02-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated80 mg/1oralAurobindo Pharma Limited2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated5 mg/1oralBlu Pharmceuticals Llc2011-10-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralNorth Star Rx Llc2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralGen Source Rx2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralCardinal Health2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralInternational Labs, Inc.2013-09-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralLake Erie Medical DBA Quality Care Products LLC2008-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralAv Pak2014-12-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralPd Rx Pharmaceuticals, Inc.2006-06-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralProficient Rx LP2008-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralTeva Pharmaceuticals USA Inc2006-06-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralLupin Pharmaceuticals, Inc.2007-06-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralPreferred Pharmaceuticals, Inc.2012-03-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2012-11-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated5 mg/1oralContract Pharmacy Services Pa2010-08-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralCamber Pharmaceuticals, Inc.2014-12-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet5 mg/1oralRebel Distributors Corp2009-09-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet20 mg/1oralCardinal Health2011-05-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet20 mg/1oralPhysicians Total Care, Inc.2008-07-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet20 mg/1oralMicro Labs Limited2013-06-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralIngenus Pharmaceuticals, LLC2012-01-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralSt Marys Medical Park Pharmacy2008-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralbryant ranch prepack2008-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated80 mg/1oralZydus Pharmaceuticals (USA) Inc.2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralMc Kesson Contract Packaging2011-10-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated80 mg/1oralBiocon Limited2015-12-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet10 mg/1oralREMEDYREPACK INC.2011-07-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralAurolife Pharma LLC2009-11-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated80 mg/1oralLupin Pharmaceuticals, Inc.2015-12-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralRx Change Co.2014-11-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralBlu Pharmaceuticals, LLC2008-02-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralCardinal Health2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralDr. Reddy's Laboratories Limited2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralAphena Pharma Solutions Tennessee, Llc2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralREMEDYREPACK INC.2013-05-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated20 mg/1oralDIRECT RX2014-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated5 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2013-01-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralMajor Pharmaceuticals2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated40 mg/1oralPreferred Pharmaceuticals, Inc.2014-07-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated10 mg/1oralAurobindo Pharma Limited2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated5 mg/1oralAv Pak2014-12-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simvastatintablet, film coated5 mg/1oralNorth Star Rx Llc2006-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Over the Counter ProductsNot Available
International Brands
NameCompany
CholestatKalbe
ColeminBiohorm
LabistatinSandoz
LipexMerck Sharp & Dohme
LodalesSanofi-Aventis
MedipoMediolanum Farmaceutici
NivelipolTemis-Lostalo
SimovilMerck Sharp & Dohme
SinvacorMerck Sharp & Dohme
SivastinSigma-Tau
SivatinRowex
SivinarAnfarm
SorfoxGalex
SotovastinBros
StarezinLeovan Pharmaceuticals
StarstatLupin
StarzokoDaewoong
StasivaPharmanel
StatexPliva
StaticorDarnitsa
StatinalAlet Pharmaceuticals
StativerIapharm
Brand mixtures
NameLabellerIngredients
SimcorAbb Vie Inc.
VytorinRebel Distributors Corp
SaltsNot Available
Categories
CAS number79902-63-9
WeightAverage: 418.5662
Monoisotopic: 418.271924326
Chemical FormulaC25H38O5
InChI KeyInChIKey=RYMZZMVNJRMUDD-HGQWONQESA-N
InChI
InChI=1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1
IUPAC Name
(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
SMILES
[H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H]1C[C@@H](O)CC(=O)O1)OC(=O)C(C)(C)CC
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as delta valerolactones. These are cyclic organic compounds containing an oxan-2- one moiety.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassLactones
Sub ClassDelta valerolactones
Direct ParentDelta valerolactones
Alternative Parents
Substituents
  • Delta_valerolactone
  • Fatty acid ester
  • Delta valerolactone
  • Fatty acyl
  • Oxane
  • Dicarboxylic acid or derivatives
  • Saccharide
  • Secondary alcohol
  • Carboxylic acid ester
  • Oxacycle
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Alcohol
  • Aliphatic heteropolycyclic compound
Molecular FrameworkAliphatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of hypercholesterolemia and for the reduction in the risk of cardiac heart disease mortality and cardiovascular events. It can also be used in adolescent patients for the treatment of heterozygous familial hypercholesterolemia.
PharmacodynamicsSimvastatin, the methylated form of lovastatin, is an oral antilipemic agent which inhibits HMG-CoA reductase. Simvastatin is used in the treatment of primary hypercholesterolemia and is effective in reducing total and LDL-cholesterol as well as plasma triglycerides and apolipoprotein B.
Mechanism of actionSimvastatin is a prodrug in which the 6-membered lactone ring of simvastatin is hydrolyzed in vivo to generate the beta,delta-dihydroxy acid, an active metabolite structurally similar to HMG-CoA (hydroxymethylglutaryl CoA). Once hydrolyzed, simvastatin competes with HMG-CoA for HMG-CoA reductase, a hepatic microsomal enzyme. Interference with the activity of this enzyme reduces the quantity of mevalonic acid, a precursor of cholesterol.
AbsorptionAbsorption of simvastatin, estimated relative to an intravenous reference dose, in each of two animal species tested, averaged about 85% of an oral dose. In animal studies, after oral dosing, simvastatin achieved substantially higher concentrations in the liver than in non-target tissues. However, because simvastatin undergoes extensive first-pass metabolism, the availability of the drug in the systemic is low. Peak plasma concentration occurs 1.3 - 2.4 hours after administration.
Volume of distribution

Simvastatin can cross the blood-brain-barrier.

Protein bindingBoth simvastatin and its β-hydroxyacid metabolite are highly bound (approximately 95%) to human plasma proteins.
Metabolism

Hepatic, simvastatin is a substrate for CYP3A4. The major active metabolites of simvastatin are β-hydroxyacid metabolite and its 6'-hydroxy, 6'-hydroxymethyl, and 6'-exomethylene derivatives

SubstrateEnzymesProduct
Simvastatin
simvastatin hydroxy acidDetails
Route of eliminationFollowing an oral dose of 14C-labeled simvastatin in man, 13% of the dose was excreted in urine and 60% in feces.
Half life3 hours
ClearanceNot Available
ToxicityThe most common adverse reactions that lead to discontinuation of therapy include gastrointestinal disorders (0.5%), myalgia (0.1%), and arthralgia (0.1%).
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated Effects
Interacting Gene/EnzymeSNP RS IDAllele nameDefining changeEffectReference(s)
Kinesin-like protein KIF6
Gene symbol: KIF6
UniProt: Q6ZMV9
rs20455 Not AvailableC AlleleImproved response to statin drugs18222353
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Gene symbol: HMGCR
UniProt: P04035
rs17244841 Not AvailableT AlleleReduced response to statin drugs15199031
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9475
Blood Brain Barrier+0.9422
Caco-2 permeable-0.5951
P-glycoprotein substrateSubstrate0.8508
P-glycoprotein inhibitor IInhibitor0.7335
P-glycoprotein inhibitor IIInhibitor0.8387
Renal organic cation transporterNon-inhibitor0.8435
CYP450 2C9 substrateNon-substrate0.835
CYP450 2D6 substrateNon-substrate0.9254
CYP450 3A4 substrateSubstrate0.7513
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorNon-inhibitor0.9307
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorInhibitor0.7959
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8682
Ames testNon AMES toxic0.792
CarcinogenicityNon-carcinogens0.9408
BiodegradationNot ready biodegradable0.9657
Rat acute toxicity2.0061 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8921
hERG inhibition (predictor II)Non-inhibitor0.8573
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Synthon pharmaceuticals ltd
  • Accord healthcare inc
  • Aurobindo pharma ltd
  • Dr reddys laboratories inc
  • Dr reddys laboratories ltd
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Lupin ltd
  • Matrix laboratories ltd
  • Perrigo r and d co
  • Ranbaxy laboratories ltd
  • Sandoz inc
  • Watson laboratories inc
  • Zydus pharmaceuticals usa inc
  • Merck research laboratories div merck co inc
Packagers
Dosage forms
FormRouteStrength
Tabletoral80 mg
Tablet, film coated, extended releaseoral
Tabletoral10 mg/1
Tabletoral20 mg/1
Tabletoral40 mg/1
Tabletoral5 mg/1
Tabletoral80 mg/1
Tabletoral
Tabletoral10 mg
Tabletoral20 mg
Tabletoral40 mg
Tabletoral5 mg
Tablet, film coatedoral10 mg/1
Tablet, film coatedoral20 mg/1
Tablet, film coatedoral40 mg/1
Tablet, film coatedoral5 mg/1
Tablet, film coatedoral80 mg/1
Prices
Unit descriptionCostUnit
Zocor 90 40 mg tablet Bottle525.16USD bottle
Simvastatin 100% powder10.71USD g
Vytorin 10-20 mg tablet5.05USD tablet
Vytorin 10-40 mg tablet5.05USD tablet
Vytorin 10-10 mg tablet4.97USD tablet
Zocor 20 mg tablet4.69USD tablet
Zocor 80 mg tablet4.69USD tablet
Vytorin 10-80 mg tablet4.63USD tablet
Zocor 40 mg tablet4.11USD tablet
Simvastatin 20 mg tablet3.83USD tablet
Simvastatin 40 mg tablet3.83USD tablet
Simvastatin 80 mg tablet3.83USD tablet
Zocor 10 mg tablet2.89USD tablet
Simvastatin 10 mg tablet2.31USD tablet
Zocor 5 mg tablet1.99USD tablet
Simvastatin 5 mg tablet1.63USD tablet
Phl-Simvastatin 40 mg Tablet1.45USD tablet
Phl-Simvastatin 80 mg Tablet1.45USD tablet
Pms-Simvastatin 20 mg Tablet1.45USD tablet
Pms-Simvastatin 40 mg Tablet1.45USD tablet
Pms-Simvastatin 80 mg Tablet1.45USD tablet
Ran-Simvastatin 20 mg Tablet1.45USD tablet
Ran-Simvastatin 40 mg Tablet1.45USD tablet
Ran-Simvastatin 80 mg Tablet1.45USD tablet
Ratio-Simvastatin 20 mg Tablet1.45USD tablet
Ratio-Simvastatin 40 mg Tablet1.45USD tablet
Ratio-Simvastatin 80 mg Tablet1.45USD tablet
Sandoz Simvastatin 20 mg Tablet1.45USD tablet
Sandoz Simvastatin 40 mg Tablet1.45USD tablet
Sandoz Simvastatin 80 mg Tablet1.45USD tablet
Apo-Simvastatin 20 mg Tablet1.45USD tablet
Apo-Simvastatin 40 mg Tablet1.45USD tablet
Apo-Simvastatin 80 mg Tablet1.45USD tablet
Co Simvastatin 20 mg Tablet1.45USD tablet
Co Simvastatin 40 mg Tablet1.45USD tablet
Co Simvastatin 80 mg Tablet1.45USD tablet
Jamp-Simvastatin 20 mg Tablet1.45USD tablet
Jamp-Simvastatin 40 mg Tablet1.45USD tablet
Jamp-Simvastatin 80 mg Tablet1.45USD tablet
Mylan-Simvastatin 20 mg Tablet1.45USD tablet
Mylan-Simvastatin 40 mg Tablet1.45USD tablet
Mylan-Simvastatin 80 mg Tablet1.45USD tablet
Novo-Simvastatin 20 mg Tablet1.45USD tablet
Novo-Simvastatin 40 mg Tablet1.45USD tablet
Novo-Simvastatin 80 mg Tablet1.45USD tablet
Phl-Simvastatin 20 mg Tablet1.45USD tablet
Apo-Simvastatin 10 mg Tablet1.17USD tablet
Co Simvastatin 10 mg Tablet1.17USD tablet
Jamp-Simvastatin 10 mg Tablet1.17USD tablet
Mylan-Simvastatin 10 mg Tablet1.17USD tablet
Novo-Simvastatin 10 mg Tablet1.17USD tablet
Phl-Simvastatin 10 mg Tablet1.17USD tablet
Pms-Simvastatin 10 mg Tablet1.17USD tablet
Ran-Simvastatin 10 mg Tablet1.17USD tablet
Ratio-Simvastatin 10 mg Tablet1.17USD tablet
Sandoz Simvastatin 10 mg Tablet1.17USD tablet
Apo-Simvastatin 5 mg Tablet0.59USD tablet
Co Simvastatin 5 mg Tablet0.59USD tablet
Jamp-Simvastatin 5 mg Tablet0.59USD tablet
Mylan-Simvastatin 5 mg Tablet0.59USD tablet
Novo-Simvastatin 5 mg Tablet0.59USD tablet
Phl-Simvastatin 5 mg Tablet0.59USD tablet
Pms-Simvastatin 5 mg Tablet0.59USD tablet
Ran-Simvastatin 5 mg Tablet0.59USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
CountryPatent NumberApprovedExpires (estimated)
United States58469661993-09-212013-09-21
United StatesRE377211997-04-252017-04-25
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point135-138 °CPhysProp
water solubilityInsoluble FDA label
logP4.68HANSCH,C ET AL. (1995)
Predicted Properties
PropertyValueSource
Water Solubility0.0122 mg/mLALOGPS
logP4.51ALOGPS
logP4.46ChemAxon
logS-4.5ALOGPS
pKa (Strongest Acidic)14.91ChemAxon
pKa (Strongest Basic)-2.8ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area72.83 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity117.68 m3·mol-1ChemAxon
Polarizability47.85 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
MSMass Spectrum (Electron Ionization)splash10-bz20000000-d04758924bf88a90c017View in MoNA
References
Synthesis Reference

Shieh-Shung J. Chen, Byron H. Arison, “Process for the preparation of 3-keto, 5-hydroxy simvastatin analogs.” U.S. Patent US4965200, issued April, 1981.

US4965200
General References
  1. Wolozin B, Wang SW, Li NC, Lee A, Lee TA, Kazis LE: Simvastatin is associated with a reduced incidence of dementia and Parkinson’s disease. BMC Med. 2007 Jul 19;5:20. Pubmed
External Links
ATC CodesC10AA01
AHFS Codes
  • 24:06.08
PDB EntriesNot Available
FDA labelDownload (102 KB)
MSDSDownload (87.5 KB)
Interactions
Drug Interactions
Drug
AcipimoxAcipimox may increase the myopathic rhabdomyolysis activities of Simvastatin.
Aluminum hydroxideThe serum concentration of Simvastatin can be decreased when it is combined with Aluminum hydroxide.
AmiodaroneThe metabolism of Simvastatin can be decreased when combined with Amiodarone.
AmlodipineThe serum concentration of Simvastatin can be increased when it is combined with Amlodipine.
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Simvastatin.
AprepitantThe serum concentration of Simvastatin can be increased when it is combined with Aprepitant.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Simvastatin.
AtazanavirThe serum concentration of Simvastatin can be increased when it is combined with Atazanavir.
AzithromycinAzithromycin may increase the myopathic rhabdomyolysis activities of Simvastatin.
BatimastatThe serum concentration of Simvastatin can be increased when it is combined with Batimastat.
BexaroteneThe serum concentration of Simvastatin can be decreased when it is combined with Bexarotene.
BezafibrateBezafibrate may increase the myopathic rhabdomyolysis activities of Simvastatin.
BoceprevirThe serum concentration of Simvastatin can be increased when it is combined with Boceprevir.
BosentanThe metabolism of Simvastatin can be increased when combined with Bosentan.
Calcium carbonateThe serum concentration of Simvastatin can be decreased when it is combined with Calcium carbonate.
CeritinibThe serum concentration of Simvastatin can be increased when it is combined with Ceritinib.
CiprofibrateThe risk or severity of adverse effects can be increased when Ciprofibrate is combined with Simvastatin.
ClarithromycinThe serum concentration of Simvastatin can be increased when it is combined with Clarithromycin.
CobicistatThe serum concentration of Simvastatin can be increased when it is combined with Cobicistat.
ColchicineColchicine may increase the myopathic rhabdomyolysis activities of Simvastatin.
ConivaptanThe serum concentration of Simvastatin can be increased when it is combined with Conivaptan.
CyclosporineThe serum concentration of Simvastatin can be increased when it is combined with Cyclosporine.
Cyproterone acetateThe serum concentration of Simvastatin can be increased when it is combined with Cyproterone acetate.
DabrafenibThe serum concentration of Simvastatin can be decreased when it is combined with Dabrafenib.
DaclatasvirThe serum concentration of Simvastatin can be increased when it is combined with Daclatasvir.
DanazolThe serum concentration of Simvastatin can be increased when it is combined with Danazol.
DaptomycinThe risk or severity of adverse effects can be increased when Simvastatin is combined with Daptomycin.
DarunavirThe serum concentration of Simvastatin can be increased when it is combined with Darunavir.
DasatinibThe serum concentration of Simvastatin can be increased when it is combined with Dasatinib.
DeferasiroxThe serum concentration of Simvastatin can be decreased when it is combined with Deferasirox.
DicoumarolSimvastatin may increase the anticoagulant activities of Dicoumarol.
DiltiazemThe serum concentration of Diltiazem can be increased when it is combined with Simvastatin.
DronedaroneThe serum concentration of Simvastatin can be increased when it is combined with Dronedarone.
EfavirenzThe serum concentration of Simvastatin can be decreased when it is combined with Efavirenz.
EltrombopagThe serum concentration of Simvastatin can be increased when it is combined with Eltrombopag.
ErythromycinThe serum concentration of Simvastatin can be increased when it is combined with Erythromycin.
Eslicarbazepine acetateThe serum concentration of Simvastatin can be decreased when it is combined with Eslicarbazepine acetate.
EtravirineThe serum concentration of Simvastatin can be decreased when it is combined with Etravirine.
FenofibrateThe risk or severity of adverse effects can be increased when Fenofibrate is combined with Simvastatin.
FluconazoleThe serum concentration of Simvastatin can be increased when it is combined with Fluconazole.
FosamprenavirThe serum concentration of Simvastatin can be increased when it is combined with Fosamprenavir.
FosaprepitantThe serum concentration of Simvastatin can be increased when it is combined with Fosaprepitant.
FosphenytoinThe serum concentration of Simvastatin can be decreased when it is combined with Fosphenytoin.
Fusidic AcidThe risk or severity of adverse effects can be increased when Fusidic Acid is combined with Simvastatin.
GemfibrozilGemfibrozil may increase the myopathic rhabdomyolysis activities of Simvastatin.
IdelalisibThe serum concentration of Simvastatin can be increased when it is combined with Idelalisib.
ImatinibThe metabolism of Simvastatin can be decreased when combined with Imatinib.
IndinavirThe serum concentration of Simvastatin can be increased when it is combined with Indinavir.
IsoflurophateThe serum concentration of Simvastatin can be increased when it is combined with Isoflurophate.
ItraconazoleThe serum concentration of Simvastatin can be increased when it is combined with Itraconazole.
IvacaftorThe serum concentration of Simvastatin can be increased when it is combined with Ivacaftor.
KetoconazoleThe serum concentration of Simvastatin can be increased when it is combined with Ketoconazole.
LanthanumThe serum concentration of Lanthanum can be decreased when it is combined with Simvastatin.
LercanidipineThe serum concentration of Simvastatin can be increased when it is combined with Lercanidipine.
LomitapideThe serum concentration of Simvastatin can be increased when it is combined with Lomitapide.
LuliconazoleThe serum concentration of Simvastatin can be increased when it is combined with Luliconazole.
Magnesium oxideThe serum concentration of Simvastatin can be decreased when it is combined with Magnesium oxide.
MifepristoneThe serum concentration of Simvastatin can be increased when it is combined with Mifepristone.
MitotaneThe serum concentration of Simvastatin can be decreased when it is combined with Mitotane.
NefazodoneThe serum concentration of Simvastatin can be increased when it is combined with Nefazodone.
NelfinavirThe serum concentration of Simvastatin can be increased when it is combined with Nelfinavir.
NetupitantThe serum concentration of Simvastatin can be increased when it is combined with Netupitant.
NiacinThe risk or severity of adverse effects can be increased when Niacin is combined with Simvastatin.
NicotinamideThe risk or severity of adverse effects can be increased when Nicotinamide is combined with Simvastatin.
PalbociclibThe serum concentration of Simvastatin can be increased when it is combined with Palbociclib.
PazopanibSimvastatin may increase the hepatotoxic activities of Pazopanib.
PhenytoinThe serum concentration of Simvastatin can be decreased when it is combined with Phenytoin.
PosaconazoleThe serum concentration of Simvastatin can be increased when it is combined with Posaconazole.
QuinineThe serum concentration of Simvastatin can be increased when it is combined with Quinine.
RaltegravirRaltegravir may increase the myopathic rhabdomyolysis activities of Simvastatin.
RanolazineThe serum concentration of Simvastatin can be increased when it is combined with Ranolazine.
RifabutinThe serum concentration of Simvastatin can be decreased when it is combined with Rifabutin.
RitonavirThe serum concentration of Simvastatin can be increased when it is combined with Ritonavir.
SaquinavirThe serum concentration of Simvastatin can be increased when it is combined with Saquinavir.
SiltuximabThe serum concentration of Simvastatin can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Simvastatin can be increased when it is combined with Simeprevir.
St. John's WortThe metabolism of Simvastatin can be increased when combined with St. John's Wort.
StiripentolThe serum concentration of Simvastatin can be increased when it is combined with Stiripentol.
TelaprevirThe serum concentration of Simvastatin can be increased when it is combined with Telaprevir.
TelithromycinThe serum concentration of Simvastatin can be increased when it is combined with Telithromycin.
TeriflunomideThe serum concentration of Simvastatin can be increased when it is combined with Teriflunomide.
TicagrelorThe serum concentration of Simvastatin can be increased when it is combined with Ticagrelor.
TipranavirThe serum concentration of Simvastatin can be increased when it is combined with Tipranavir.
TocilizumabThe serum concentration of Simvastatin can be decreased when it is combined with Tocilizumab.
TrabectedinSimvastatin may increase the myopathic rhabdomyolysis activities of Trabectedin.
VerapamilThe serum concentration of Simvastatin can be increased when it is combined with Verapamil.
VoriconazoleThe serum concentration of Simvastatin can be increased when it is combined with Voriconazole.
Food Interactions
  • Avoid alcohol.
  • Avoid drastic changes in dietary habit.
  • Avoid taking with grapefruit juice.

Targets

1. 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Kind: Protein

Organism: Human

Pharmacological action: yes

Actions: inhibitor

Components

Name UniProt ID Details
3-hydroxy-3-methylglutaryl-coenzyme A reductase P04035 Details

References:

  1. Cenedella RJ, Kuszak JR, Al-Ghoul KJ, Qin S, Sexton PS: Discordant expression of the sterol pathway in lens underlies simvastatin-induced cataracts in Chbb: Thom rats. J Lipid Res. 2003 Jan;44(1):198-211. Pubmed
  2. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. Pubmed
  3. Kocarek TA, Dahn MS, Cai H, Strom SC, Mercer-Haines NA: Regulation of CYP2B6 and CYP3A expression by hydroxymethylglutaryl coenzyme A inhibitors in primary cultured human hepatocytes. Drug Metab Dispos. 2002 Dec;30(12):1400-5. Pubmed
  4. Liu L, Zhang R, Zhao JJ, Rogers JD, Hsieh JY, Fang W, Matuszewski BK, Dobrinska MR: Determination of simvastatin-derived HMG-CoA reductase inhibitors in biomatrices using an automated enzyme inhibition assay with radioactivity detection. J Pharm Biomed Anal. 2003 Apr 24;32(1):107-23. Pubmed
  5. Pappu AS, Bacon SP, Illingworth DR: Residual effects of lovastatin and simvastatin on urinary mevalonate excretions in patients with familial hypercholesterolemia. J Lab Clin Med. 2003 Apr;141(4):250-6. Pubmed
  6. Stoebner PE, Michot C, Ligeron C, Durand L, Meynadier J, Meunier L: [Simvastatin-induced lichen planus pemphigoides] Ann Dermatol Venereol. 2003 Feb;130(2 Pt 1):187-90. Pubmed

2. Integrin beta-2

Kind: Protein

Organism: Human

Pharmacological action: no

Actions: other

Components

Name UniProt ID Details
Integrin beta-2 P05107 Details

References:

  1. Fujii T, Masuyama K, Kawashima K: Simvastatin regulates non-neuronal cholinergic activity in T lymphocytes via CD11a-mediated pathways. J Neuroimmunol. 2006 Oct;179(1-2):101-7. Epub 2006 Jul 10. Pubmed
  2. Fujii T, Takada-Takatori Y, Kawashima K: Roles played by lymphocyte function-associated antigen-1 in the regulation of lymphocytic cholinergic activity. Life Sci. 2007 May 30;80(24-25):2320-4. Epub 2007 Jan 17. Pubmed
  3. Katano H, Pesnicak L, Cohen JI: Simvastatin induces apoptosis of Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines and delays development of EBV lymphomas. Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4960-5. Epub 2004 Mar 23. Pubmed
  4. Takahashi HK, Mori S, Iwagaki H, Yoshino T, Tanaka N, Nishibori M: Simvastatin induces interleukin-18 production in human peripheral blood mononuclear cells. Clin Immunol. 2005 Sep;116(3):211-6. Pubmed

Enzymes

1. Cytochrome P450 3A4

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor inducer

Components

Name UniProt ID Details
Cytochrome P450 3A4 P08684 Details

References:

  1. Neuvonen PJ, Niemi M, Backman JT: Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance. Clin Pharmacol Ther. 2006 Dec;80(6):565-81. Pubmed
  2. Cohen LH, van Leeuwen RE, van Thiel GC, van Pelt JF, Yap SH: Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos. 2000 Dec;21(9):353-64. Pubmed
  3. Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). Accessed May 28, 2010.
  4. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. Pubmed
  5. Information Hyperlinked Over Proteins (iHOP) – Website
  6. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed
  7. Galetin A, Clarke SE, Houston JB: Quinidine and haloperidol as modifiers of CYP3A4 activity: multisite kinetic model approach. Drug Metab Dispos. 2002 Dec;30(12):1512-22. Pubmed

2. Cytochrome P450 3A5

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 3A5 P20815 Details

References:

  1. Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). Accessed May 28, 2010.
  2. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. Pubmed
  3. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

3. Cytochrome P450 3A7

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 3A7 P24462 Details

References:

  1. Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). Accessed May 28, 2010.

4. Cytochrome P450 2C8

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Cytochrome P450 2C8 P10632 Details

References:

  1. Neuvonen PJ, Niemi M, Backman JT: Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance. Clin Pharmacol Ther. 2006 Dec;80(6):565-81. Pubmed
  2. Tornio A, Pasanen MK, Laitila J, Neuvonen PJ, Backman JT: Comparison of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) as inhibitors of cytochrome P450 2C8. Basic Clin Pharmacol Toxicol. 2005 Aug;97(2):104-8. Pubmed
  3. Walsky RL, Gaman EA, Obach RS: Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78. Pubmed
  4. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

5. Cytochrome P450 2C9

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor inducer

Components

Name UniProt ID Details
Cytochrome P450 2C9 P11712 Details

References:

  1. Cohen LH, van Leeuwen RE, van Thiel GC, van Pelt JF, Yap SH: Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos. 2000 Dec;21(9):353-64. Pubmed
  2. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. Pubmed
  3. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

6. Cytochrome P450 2C19

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Cytochrome P450 2C19 P33261 Details

References:

  1. Cohen LH, van Leeuwen RE, van Thiel GC, van Pelt JF, Yap SH: Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos. 2000 Dec;21(9):353-64. Pubmed

7. Cytochrome P450 2D6

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Cytochrome P450 2D6 P10635 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

8. Cytochrome P450 2B6

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inducer

Components

Name UniProt ID Details
Cytochrome P450 2B6 P20813 Details

References:

  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. Pubmed

9. UDP-glucuronosyltransferase 1-1

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
UDP-glucuronosyltransferase 1-1 P22309 Details

References:

  1. http://www.pharmacologyweekly.com/content/pages/ugt-enzymes-medications-herbs-substrate-inhibitor-inducer

10. UDP-glucuronosyltransferase 1-3

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
UDP-glucuronosyltransferase 1-3 P35503 Details

References:

  1. http://www.pharmacologyweekly.com/content/pages/ugt-enzymes-medications-herbs-substrate-inhibitor-inducer

11. UDP-glucuronosyltransferase 2B7

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
UDP-glucuronosyltransferase 2B7 P16662 Details

References:

  1. http://www.pharmacologyweekly.com/content/pages/ugt-enzymes-medications-herbs-substrate-inhibitor-inducer

Transporters

1. Multidrug resistance protein 1

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Multidrug resistance protein 1 P08183 Details

References:

  1. Wang E, Casciano CN, Clement RP, Johnson WW: HMG-CoA reductase inhibitors (statins) characterized as direct inhibitors of P-glycoprotein. Pharm Res. 2001 Jun;18(6):800-6. Pubmed
  2. Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. Pubmed
  3. Hochman JH, Pudvah N, Qiu J, Yamazaki M, Tang C, Lin JH, Prueksaritanont T: Interactions of human P-glycoprotein with simvastatin, simvastatin acid, and atorvastatin. Pharm Res. 2004 Sep;21(9):1686-91. Pubmed
  4. Sieczkowski E, Lehner C, Ambros PF, Hohenegger M: Double impact on p-glycoprotein by statins enhances doxorubicin cytotoxicity in human neuroblastoma cells. Int J Cancer. 2010 May 1;126(9):2025-35. Pubmed

2. Solute carrier organic anion transporter family member 1A2

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Solute carrier organic anion transporter family member 1A2 P46721 Details

References:

  1. Hsiang B, Zhu Y, Wang Z, Wu Y, Sasseville V, Yang WP, Kirchgessner TG: A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J Biol Chem. 1999 Dec 24;274(52):37161-8. Pubmed

3. Solute carrier organic anion transporter family member 1B1

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Solute carrier organic anion transporter family member 1B1 Q9Y6L6 Details

References:

  1. Hsiang B, Zhu Y, Wang Z, Wu Y, Sasseville V, Yang WP, Kirchgessner TG: A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J Biol Chem. 1999 Dec 24;274(52):37161-8. Pubmed
  2. Kameyama Y, Yamashita K, Kobayashi K, Hosokawa M, Chiba K: Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1*5, SLCO1B1*15 and SLCO1B1*15+C1007G, by using transient expression systems of HeLa and HEK293 cells. Pharmacogenet Genomics. 2005 Jul;15(7):513-22. Pubmed

4. Canalicular multispecific organic anion transporter 1

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Canalicular multispecific organic anion transporter 1 Q92887 Details

References:

  1. Becker ML, Elens LL, Visser LE, Hofman A, Uitterlinden AG, van Schaik RH, Stricker BH: Genetic variation in the ABCC2 gene is associated with dose decreases or switches to other cholesterol-lowering drugs during simvastatin and atorvastatin therapy. Pharmacogenomics J. 2013 Jun;13(3):251-6. doi: 10.1038/tpj.2011.59. Epub 2011 Dec 20. Pubmed

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Drug created on June 13, 2005 07:24 / Updated on September 16, 2013 17:11