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Identification
NameAbiraterone
Accession NumberDB05812
TypeSmall Molecule
GroupsApproved
DescriptionAbiraterone is a derivative of steroidal progesterone and is an innovative drug that offers clinical benefit to patients with hormone refractory prostate cancer. Abiraterone is administered as an acetate salt prodrug because it has a higher bioavailability and less susceptible to hydrolysis than abiraterone itself. FDA approved on April 28, 2011.
Structure
Thumb
Synonyms
(3beta)-17-(Pyridin-3-yl)androsta-5,16-dien-3-ol
17-(3-Pyridyl)androsta-5,16-dien-3beta-ol
External Identifiers
  • CB7630
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Zytigatablet250 mg/1oralJanssen Biotech, Inc.2011-04-28Not applicableUs
Zytigatablet250 mgoralJanssen Inc2011-07-28Not applicableCanada
Zytigatablet500 mgoralJanssen IncNot applicableNot applicableCanada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Abiraterone acetate
ThumbNot applicableDBSALT001173
Categories
UNIIG819A456D0
CAS number154229-19-3
WeightAverage: 349.509
Monoisotopic: 349.240564619
Chemical FormulaC24H31NO
InChI KeyInChIKey=GZOSMCIZMLWJML-VJLLXTKPSA-N
InChI
InChI=1S/C24H31NO/c1-23-11-9-18(26)14-17(23)5-6-19-21-8-7-20(16-4-3-13-25-15-16)24(21,2)12-10-22(19)23/h3-5,7,13,15,18-19,21-22,26H,6,8-12,14H2,1-2H3/t18-,19-,21-,22-,23-,24+/m0/s1
IUPAC Name
(1S,2R,5S,10R,11S,15S)-2,15-dimethyl-14-(pyridin-3-yl)tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-7,13-dien-5-ol
SMILES
[H][C@@]12CC=C(C3=CC=CN=C3)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@@H](O)CC[C@]12C
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as androgens and derivatives. These are 3-hydroxylated C19 steroid hormones. They are known to favor the development of masculine characteristics. They also show profound effects on scalp and body hair in humans.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassSteroids and steroid derivatives
Sub ClassAndrostane steroids
Direct ParentAndrogens and derivatives
Alternative Parents
Substituents
  • Androgen-skeleton
  • 3-beta-hydroxysteroid
  • 3-beta-hydroxy-delta-5-steroid
  • Hydroxysteroid
  • 3-hydroxysteroid
  • 3-hydroxy-delta-5-steroid
  • Delta-5-steroid
  • Pyridine
  • Heteroaromatic compound
  • Cyclic alcohol
  • Secondary alcohol
  • Azacycle
  • Organoheterocyclic compound
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Alcohol
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationUsed in combination with prednisone for the treatment of metastatic, castration-resistant prostate cancer.
PharmacodynamicsAbiraterone is associated with decreases in PSA levels, tumor shrinkage (as evaluated by RECIST criteria), radiographic regression of bone metastases and improvement in pain. Levels of adrenocorticotropic hormones increased up to 6-fold but this can be suppressed by dexamethasone.
Mechanism of actionAbiraterone is an orally active inhibitor of the steroidal enzyme CYP17A1 (17 alpha-hydroxylase/C17,20 lyase). It inhibits CYP17A1 in a selective and irreversible manner via covalent binding mechanism. CYP17A1 is an enzyme that catalyzes the biosynthesis of androgen and is highly expressed in testicular, adrenal, and prostatic tumor tissue. More specifically, abiraterone inhibits the conversion of 17-hydroxyprognenolone to dehydroepiandrosterone (DHEA) by the enzyme CYP17A1 to decrease serum levels of testosterone and other androgens.
Related Articles
AbsorptionAbiraterone itself is poorly absorbed and is susceptible to hydrolysis by esterases. The salt form, abiraterone acetate, is a prodrug which has a much higher oral bioavailability and is also esterase resistant. Peak drug concentrations of abiraterone were reached in 1.5 - 4 hours. Abiraterone acetate was rapidly and completely deacetylated into abiraterone-the parent salt form was not detectable in early pharmacokinetic studies. Food and high fat meals increases absorption 4.4-fold.
Volume of distribution

Vdss= 19,669 ± 13,358 L

Protein binding>99% protein bound to alpha-1-acid glycoprotein and albumin.
Metabolism

Abiraterone acetate is hydrolyzed into active metabolite abiraterone via esterases. CYP3A4 and SULT2A1 further metabolizes abiraterone into two inactive metabolites called abiraterone sulfate and N-oxide abiraterone sulfate.

SubstrateEnzymesProduct
Abiraterone
Not Available
abiraterone sulfateDetails
Abiraterone
Not Available
N-oxide abiraterone sulfateDetails
Route of eliminationExcreted via feces (~88%) and urine (~5%)
Half lifeTerminal elimination half-life = 5-14 hours
ClearanceNot Available
ToxicityToxicity is related to the blockade of 17α-hydroxylase activity. Blockade results in the accumulation of upstream mineralocorticoids like 11-deoxycorticosterone leading to secondary hyperaldosteronism. Signs of hydroaldosteronism include fluid retention and hypokalemia. Mineralocorticoid receptor antagonists may be used to treat signs and symptoms.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier+0.98
Caco-2 permeable+0.7245
P-glycoprotein substrateSubstrate0.6583
P-glycoprotein inhibitor IInhibitor0.5
P-glycoprotein inhibitor IINon-inhibitor0.8831
Renal organic cation transporterNon-inhibitor0.7453
CYP450 2C9 substrateNon-substrate0.854
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.6478
CYP450 1A2 substrateInhibitor0.5124
CYP450 2C9 inhibitorNon-inhibitor0.8046
CYP450 2D6 inhibitorNon-inhibitor0.8693
CYP450 2C19 inhibitorNon-inhibitor0.5349
CYP450 3A4 inhibitorInhibitor0.7176
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.5363
Ames testNon AMES toxic0.8499
CarcinogenicityNon-carcinogens0.9616
BiodegradationNot ready biodegradable0.9565
Rat acute toxicity2.4407 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8318
hERG inhibition (predictor II)Non-inhibitor0.7059
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
Tabletoral250 mg/1
Tabletoral250 mg
Tabletoral500 mg
PricesNot Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5604213 No1996-12-132016-12-13Us
US8822438 No2007-08-242027-08-24Us
Properties
StateSolid
Experimental PropertiesNot Available
Predicted Properties
PropertyValueSource
Water Solubility0.00305 mg/mLALOGPS
logP5.1ALOGPS
logP3.97ChemAxon
logS-5.1ALOGPS
pKa (Strongest Acidic)18.2ChemAxon
pKa (Strongest Basic)4.81ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area33.12 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity107.3 m3·mol-1ChemAxon
Polarizability42.04 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis ReferenceNot Available
General References
  1. O'Donnell A, Judson I, Dowsett M, Raynaud F, Dearnaley D, Mason M, Harland S, Robbins A, Halbert G, Nutley B, Jarman M: Hormonal impact of the 17alpha-hydroxylase/C(17,20)-lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancer. Br J Cancer. 2004 Jun 14;90(12):2317-25. [PubMed:15150570 ]
  2. Ryan CJ, Cheng ML: Abiraterone acetate for the treatment of prostate cancer. Expert Opin Pharmacother. 2013 Jan;14(1):91-6. doi: 10.1517/14656566.2013.745852. Epub 2012 Nov 30. [PubMed:23199349 ]
External Links
ATC CodesL02BX03
AHFS Codes
  • 10:00
PDB EntriesNot Available
FDA labelDownload (418 KB)
MSDSDownload (480 KB)
Interactions
Drug Interactions
Drug
4-MethoxyamphetamineThe metabolism of 4-Methoxyamphetamine can be decreased when combined with Abiraterone.
AceclofenacThe metabolism of Aceclofenac can be decreased when combined with Abiraterone.
AcenocoumarolThe serum concentration of Acenocoumarol can be increased when it is combined with Abiraterone.
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Abiraterone.
AcetylcholineThe metabolism of Acetylcholine can be decreased when combined with Abiraterone.
AcetyldigitoxinAcetyldigitoxin may decrease the cardiotoxic activities of Abiraterone.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Abiraterone.
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Abiraterone.
AgomelatineThe serum concentration of Agomelatine can be increased when it is combined with Abiraterone.
AjmalineThe metabolism of Ajmaline can be decreased when combined with Abiraterone.
AlbendazoleThe serum concentration of Albendazole can be increased when it is combined with Abiraterone.
AlmotriptanThe serum concentration of Almotriptan can be increased when it is combined with Abiraterone.
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Abiraterone.
AlosetronThe serum concentration of Alosetron can be increased when it is combined with Abiraterone.
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Abiraterone.
AlprenololThe metabolism of Alprenolol can be decreased when combined with Abiraterone.
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Abiraterone.
AminophenazoneThe serum concentration of Aminophenazone can be increased when it is combined with Abiraterone.
AminophyllineThe serum concentration of Aminophylline can be increased when it is combined with Abiraterone.
AmiodaroneThe serum concentration of Amiodarone can be increased when it is combined with Abiraterone.
AmiodaroneThe metabolism of Abiraterone can be decreased when combined with Amiodarone.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Abiraterone.
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Abiraterone.
AmoxapineThe metabolism of Amoxapine can be decreased when combined with Abiraterone.
AmoxicillinThe metabolism of Amoxicillin can be decreased when combined with Abiraterone.
AmphetamineThe metabolism of Amphetamine can be decreased when combined with Abiraterone.
AmprenavirThe serum concentration of Amprenavir can be increased when it is combined with Abiraterone.
AmsacrineThe metabolism of Amsacrine can be decreased when combined with Abiraterone.
AnagrelideThe serum concentration of Anagrelide can be increased when it is combined with Abiraterone.
AntipyrineThe serum concentration of Antipyrine can be increased when it is combined with Abiraterone.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Abiraterone.
AprepitantThe serum concentration of Abiraterone can be increased when it is combined with Aprepitant.
AprindineThe metabolism of Aprindine can be decreased when combined with Abiraterone.
Arachidonic AcidThe metabolism of Arachidonic Acid can be decreased when combined with Abiraterone.
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Abiraterone.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Abiraterone.
ArtemetherThe metabolism of Artemether can be decreased when combined with Abiraterone.
ASA404The serum concentration of ASA404 can be increased when it is combined with Abiraterone.
AsenapineThe serum concentration of Asenapine can be increased when it is combined with Abiraterone.
AstemizoleThe metabolism of Astemizole can be decreased when combined with Abiraterone.
AtazanavirThe metabolism of Abiraterone can be decreased when combined with Atazanavir.
AtomoxetineThe metabolism of Abiraterone can be decreased when combined with Atomoxetine.
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Abiraterone.
AV650The serum concentration of AV650 can be increased when it is combined with Abiraterone.
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Abiraterone.
AzelastineThe serum concentration of Azelastine can be increased when it is combined with Abiraterone.
BendamustineThe serum concentration of Bendamustine can be increased when it is combined with Abiraterone.
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Abiraterone.
Benzyl alcoholThe serum concentration of Benzyl alcohol can be increased when it is combined with Abiraterone.
BepridilThe metabolism of Bepridil can be decreased when combined with Abiraterone.
BeraprostThe serum concentration of Beraprost can be increased when it is combined with Abiraterone.
BetaxololThe serum concentration of Betaxolol can be increased when it is combined with Abiraterone.
BevacizumabBevacizumab may increase the cardiotoxic activities of Abiraterone.
BexaroteneThe serum concentration of Abiraterone can be decreased when it is combined with Bexarotene.
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Abiraterone.
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Abiraterone.
BoceprevirThe metabolism of Abiraterone can be decreased when combined with Boceprevir.
BortezomibThe serum concentration of Bortezomib can be increased when it is combined with Abiraterone.
BortezomibThe metabolism of Abiraterone can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Abiraterone can be decreased when it is combined with Bosentan.
BosentanThe serum concentration of Bosentan can be increased when it is combined with Abiraterone.
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Abiraterone.
BromazepamThe serum concentration of Bromazepam can be increased when it is combined with Abiraterone.
BrompheniramineThe serum concentration of Brompheniramine can be increased when it is combined with Abiraterone.
BufuralolThe metabolism of Bufuralol can be decreased when combined with Abiraterone.
BupivacaineThe serum concentration of Bupivacaine can be increased when it is combined with Abiraterone.
BuprenorphineThe serum concentration of Buprenorphine can be increased when it is combined with Abiraterone.
BupropionThe serum concentration of Bupropion can be increased when it is combined with Abiraterone.
BuspironeThe metabolism of Buspirone can be decreased when combined with Abiraterone.
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Abiraterone.
CabazitaxelThe risk or severity of adverse effects can be increased when Cabazitaxel is combined with Abiraterone.
CabozantinibThe metabolism of Cabozantinib can be decreased when combined with Abiraterone.
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Abiraterone.
CandesartanThe metabolism of Candesartan can be decreased when combined with Abiraterone.
CaptoprilThe metabolism of Captopril can be decreased when combined with Abiraterone.
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Abiraterone.
CarbamazepineThe serum concentration of Abiraterone can be decreased when it is combined with Carbamazepine.
CarbinoxamineThe serum concentration of Carbinoxamine can be increased when it is combined with Abiraterone.
CariprazineThe metabolism of Cariprazine can be decreased when combined with Abiraterone.
CarisoprodolThe metabolism of Carisoprodol can be decreased when combined with Abiraterone.
CarmustineThe serum concentration of Carmustine can be increased when it is combined with Abiraterone.
CarteololThe metabolism of Carteolol can be decreased when combined with Abiraterone.
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Abiraterone.
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Abiraterone.
CephalexinThe metabolism of Cephalexin can be decreased when combined with Abiraterone.
CeritinibThe serum concentration of Abiraterone can be increased when it is combined with Ceritinib.
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Abiraterone.
CevimelineThe metabolism of Cevimeline can be decreased when combined with Abiraterone.
ChloramphenicolThe metabolism of Chloramphenicol can be decreased when combined with Abiraterone.
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Abiraterone.
ChloroquineThe serum concentration of Chloroquine can be increased when it is combined with Abiraterone.
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Abiraterone.
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Abiraterone.
ChlorpropamideThe metabolism of Chlorpropamide can be decreased when combined with Abiraterone.
ChlorzoxazoneThe serum concentration of Chlorzoxazone can be increased when it is combined with Abiraterone.
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Abiraterone.
CinacalcetThe serum concentration of Cinacalcet can be increased when it is combined with Abiraterone.
CinnarizineThe serum concentration of Cinnarizine can be increased when it is combined with Abiraterone.
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Abiraterone.
CitalopramThe metabolism of Citalopram can be decreased when combined with Abiraterone.
ClarithromycinThe metabolism of Abiraterone can be decreased when combined with Clarithromycin.
ClemastineThe metabolism of Abiraterone can be decreased when combined with Clemastine.
ClenbuterolThe serum concentration of Clenbuterol can be increased when it is combined with Abiraterone.
ClevidipineThe serum concentration of Clevidipine can be increased when it is combined with Abiraterone.
ClobazamThe metabolism of Clobazam can be decreased when combined with Abiraterone.
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Abiraterone.
ClomipramineThe serum concentration of Clomipramine can be increased when it is combined with Abiraterone.
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Abiraterone.
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Abiraterone.
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Abiraterone.
ClotrimazoleThe metabolism of Abiraterone can be decreased when combined with Clotrimazole.
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Abiraterone.
CobicistatThe metabolism of Abiraterone can be decreased when combined with Cobicistat.
CodeineThe therapeutic efficacy of Codeine can be decreased when used in combination with Abiraterone.
ConivaptanThe serum concentration of Abiraterone can be increased when it is combined with Conivaptan.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Abiraterone.
CrizotinibThe metabolism of Abiraterone can be decreased when combined with Crizotinib.
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be increased when it is combined with Abiraterone.
CyclophosphamideCyclophosphamide may increase the cardiotoxic activities of Abiraterone.
CyclophosphamideThe serum concentration of Cyclophosphamide can be increased when it is combined with Abiraterone.
CyclosporineThe metabolism of Abiraterone can be decreased when combined with Cyclosporine.
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Abiraterone.
DabrafenibThe serum concentration of Abiraterone can be decreased when it is combined with Dabrafenib.
DacarbazineThe serum concentration of Dacarbazine can be increased when it is combined with Abiraterone.
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Abiraterone.
DapsoneThe serum concentration of Dapsone can be increased when it is combined with Abiraterone.
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Abiraterone.
DarunavirThe metabolism of Abiraterone can be decreased when combined with Darunavir.
DasabuvirThe serum concentration of Dasabuvir can be increased when it is combined with Abiraterone.
DasatinibThe serum concentration of Abiraterone can be increased when it is combined with Dasatinib.
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Abiraterone.
DebrisoquinThe metabolism of Debrisoquin can be decreased when combined with Abiraterone.
DeferasiroxThe serum concentration of Abiraterone can be decreased when it is combined with Deferasirox.
DelavirdineThe metabolism of Abiraterone can be decreased when combined with Delavirdine.
DesipramineThe serum concentration of Desipramine can be increased when it is combined with Abiraterone.
DeslanosideDeslanoside may decrease the cardiotoxic activities of Abiraterone.
DexamethasoneThe serum concentration of Abiraterone can be decreased when it is combined with Dexamethasone.
DexfenfluramineThe serum concentration of Dexfenfluramine can be increased when it is combined with Abiraterone.
DexmethylphenidateThe metabolism of Dexmethylphenidate can be decreased when combined with Abiraterone.
DextroamphetamineThe metabolism of Dextroamphetamine can be decreased when combined with Abiraterone.
DextromethorphanThe serum concentration of Dextromethorphan can be increased when it is combined with Abiraterone.
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Abiraterone.
DiclofenacThe serum concentration of Diclofenac can be increased when it is combined with Abiraterone.
DicoumarolThe metabolism of Dicoumarol can be decreased when combined with Abiraterone.
DigitoxinDigitoxin may decrease the cardiotoxic activities of Abiraterone.
DigoxinDigoxin may decrease the cardiotoxic activities of Abiraterone.
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Abiraterone.
DihydroergotamineThe metabolism of Abiraterone can be decreased when combined with Dihydroergotamine.
DiltiazemThe serum concentration of Diltiazem can be increased when it is combined with Abiraterone.
DiltiazemThe metabolism of Abiraterone can be decreased when combined with Diltiazem.
DinoprostoneThe serum concentration of Dinoprostone can be increased when it is combined with Abiraterone.
DiphenhydramineThe serum concentration of Diphenhydramine can be increased when it is combined with Abiraterone.
DocetaxelThe risk or severity of adverse effects can be increased when Docetaxel is combined with Abiraterone.
DolasetronThe metabolism of Dolasetron can be decreased when combined with Abiraterone.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Abiraterone.
DonepezilThe metabolism of Donepezil can be decreased when combined with Abiraterone.
DopamineThe metabolism of Dopamine can be decreased when combined with Abiraterone.
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Abiraterone.
DoxazosinThe metabolism of Doxazosin can be decreased when combined with Abiraterone.
DoxepinThe serum concentration of Doxepin can be increased when it is combined with Abiraterone.
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Abiraterone.
DoxycyclineThe metabolism of Abiraterone can be decreased when combined with Doxycycline.
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Abiraterone.
DronedaroneThe metabolism of Abiraterone can be decreased when combined with Dronedarone.
DuloxetineThe serum concentration of Duloxetine can be increased when it is combined with Abiraterone.
EfavirenzThe serum concentration of Abiraterone can be decreased when it is combined with Efavirenz.
EletriptanThe metabolism of Eletriptan can be decreased when combined with Abiraterone.
EliglustatThe metabolism of Eliglustat can be decreased when combined with Abiraterone.
EltrombopagThe serum concentration of Eltrombopag can be increased when it is combined with Abiraterone.
EncainideThe metabolism of Encainide can be decreased when combined with Abiraterone.
EnclomipheneThe metabolism of Enclomiphene can be decreased when combined with Abiraterone.
EnfuvirtideThe metabolism of Enfuvirtide can be decreased when combined with Abiraterone.
EnzalutamideThe serum concentration of Abiraterone can be decreased when it is combined with Enzalutamide.
EnzalutamideThe serum concentration of Enzalutamide can be increased when it is combined with Abiraterone.
EpinastineThe metabolism of Epinastine can be decreased when combined with Abiraterone.
EpoprostenolThe metabolism of Epoprostenol can be decreased when combined with Abiraterone.
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Abiraterone.
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Abiraterone.
ErythromycinThe metabolism of Abiraterone can be decreased when combined with Erythromycin.
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Abiraterone.
Eslicarbazepine acetateThe serum concentration of Abiraterone can be decreased when it is combined with Eslicarbazepine acetate.
EsmirtazapineThe metabolism of Esmirtazapine can be decreased when combined with Abiraterone.
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Abiraterone.
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Abiraterone.
EstroneThe serum concentration of Estrone can be increased when it is combined with Abiraterone.
Estrone sulfateThe serum concentration of Estrone sulfate can be increased when it is combined with Abiraterone.
EszopicloneThe serum concentration of Eszopiclone can be increased when it is combined with Abiraterone.
EthanolThe serum concentration of Ethanol can be increased when it is combined with Abiraterone.
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Abiraterone.
EtodolacThe metabolism of Etodolac can be decreased when combined with Abiraterone.
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Abiraterone.
EtoricoxibThe serum concentration of Etoricoxib can be increased when it is combined with Abiraterone.
EtravirineThe serum concentration of Abiraterone can be decreased when it is combined with Etravirine.
EtravirineThe metabolism of Etravirine can be decreased when combined with Abiraterone.
FamotidineThe metabolism of Famotidine can be decreased when combined with Abiraterone.
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Abiraterone.
FingolimodThe metabolism of Fingolimod can be decreased when combined with Abiraterone.
FlecainideThe metabolism of Flecainide can be decreased when combined with Abiraterone.
FluconazoleThe metabolism of Abiraterone can be decreased when combined with Fluconazole.
FlunarizineThe serum concentration of Flunarizine can be increased when it is combined with Abiraterone.
FlunitrazepamThe serum concentration of Flunitrazepam can be increased when it is combined with Abiraterone.
FluorouracilThe serum concentration of Fluorouracil can be increased when it is combined with Abiraterone.
FluoxetineThe serum concentration of Fluoxetine can be increased when it is combined with Abiraterone.
FluphenazineThe metabolism of Fluphenazine can be decreased when combined with Abiraterone.
FlurbiprofenThe metabolism of Flurbiprofen can be decreased when combined with Abiraterone.
FlutamideThe serum concentration of Flutamide can be increased when it is combined with Abiraterone.
FluvastatinThe serum concentration of Fluvastatin can be increased when it is combined with Abiraterone.
FluvoxamineThe serum concentration of Fluvoxamine can be increased when it is combined with Abiraterone.
FluvoxamineThe metabolism of Abiraterone can be decreased when combined with Fluvoxamine.
FormoterolThe metabolism of Formoterol can be decreased when combined with Abiraterone.
FosamprenavirThe metabolism of Abiraterone can be decreased when combined with Fosamprenavir.
FosaprepitantThe serum concentration of Abiraterone can be increased when it is combined with Fosaprepitant.
FosphenytoinThe serum concentration of Abiraterone can be decreased when it is combined with Fosphenytoin.
FosphenytoinThe serum concentration of Fosphenytoin can be increased when it is combined with Abiraterone.
FrovatriptanThe serum concentration of Frovatriptan can be increased when it is combined with Abiraterone.
Fusidic AcidThe serum concentration of Abiraterone can be increased when it is combined with Fusidic Acid.
GalantamineThe metabolism of Galantamine can be decreased when combined with Abiraterone.
GavestinelThe metabolism of Gavestinel can be decreased when combined with Abiraterone.
GefitinibThe metabolism of Gefitinib can be decreased when combined with Abiraterone.
GenisteinThe serum concentration of Genistein can be increased when it is combined with Abiraterone.
GliclazideThe metabolism of Gliclazide can be decreased when combined with Abiraterone.
GlimepirideThe metabolism of Glimepiride can be decreased when combined with Abiraterone.
GlipizideThe metabolism of Glipizide can be decreased when combined with Abiraterone.
GlucosamineThe metabolism of Glucosamine can be decreased when combined with Abiraterone.
GlyburideThe metabolism of Glyburide can be decreased when combined with Abiraterone.
GranisetronThe metabolism of Granisetron can be decreased when combined with Abiraterone.
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Abiraterone.
GuanabenzThe serum concentration of Guanabenz can be increased when it is combined with Abiraterone.
GuanfacineThe metabolism of Guanfacine can be decreased when combined with Abiraterone.
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Abiraterone.
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Abiraterone.
HalothaneThe metabolism of Halothane can be decreased when combined with Abiraterone.
HesperetinThe serum concentration of Hesperetin can be increased when it is combined with Abiraterone.
HexobarbitalThe serum concentration of Hexobarbital can be increased when it is combined with Abiraterone.
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Abiraterone.
HydrocodoneThe metabolism of Hydrocodone can be decreased when combined with Abiraterone.
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Abiraterone.
IbrutinibThe metabolism of Ibrutinib can be decreased when combined with Abiraterone.
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Abiraterone.
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Abiraterone.
IdelalisibThe serum concentration of Abiraterone can be increased when it is combined with Idelalisib.
IfosfamideThe serum concentration of Ifosfamide can be increased when it is combined with Abiraterone.
IloperidoneThe serum concentration of Iloperidone can be increased when it is combined with Abiraterone.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Abiraterone.
ImatinibThe metabolism of Abiraterone can be decreased when combined with Imatinib.
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Abiraterone.
ImiquimodThe serum concentration of Imiquimod can be increased when it is combined with Abiraterone.
IndinavirThe metabolism of Abiraterone can be decreased when combined with Indinavir.
indisulamThe metabolism of indisulam can be decreased when combined with Abiraterone.
IndomethacinThe metabolism of Indomethacin can be decreased when combined with Abiraterone.
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Abiraterone.
IrbesartanThe serum concentration of Irbesartan can be increased when it is combined with Abiraterone.
IsavuconazoniumThe metabolism of Abiraterone can be decreased when combined with Isavuconazonium.
IsradipineThe metabolism of Abiraterone can be decreased when combined with Isradipine.
ItraconazoleThe metabolism of Abiraterone can be decreased when combined with Itraconazole.
IvacaftorThe serum concentration of Abiraterone can be increased when it is combined with Ivacaftor.
IxazomibThe serum concentration of Ixazomib can be increased when it is combined with Abiraterone.
KetamineThe serum concentration of Ketamine can be increased when it is combined with Abiraterone.
KetobemidoneThe serum concentration of Ketobemidone can be increased when it is combined with Abiraterone.
KetoconazoleThe metabolism of Abiraterone can be decreased when combined with Ketoconazole.
KetoprofenThe metabolism of Ketoprofen can be decreased when combined with Abiraterone.
LabetalolThe metabolism of Labetalol can be decreased when combined with Abiraterone.
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Abiraterone.
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Abiraterone.
LeflunomideThe serum concentration of Leflunomide can be increased when it is combined with Abiraterone.
LesinuradThe metabolism of Lesinurad can be decreased when combined with Abiraterone.
LevobupivacaineThe serum concentration of Levobupivacaine can be increased when it is combined with Abiraterone.
LevodopaThe metabolism of Levodopa can be decreased when combined with Abiraterone.
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Abiraterone.
LicofeloneThe serum concentration of Licofelone can be increased when it is combined with Abiraterone.
LidocaineThe serum concentration of Lidocaine can be increased when it is combined with Abiraterone.
LisurideThe metabolism of Lisuride can be decreased when combined with Abiraterone.
LomefloxacinThe serum concentration of Lomefloxacin can be increased when it is combined with Abiraterone.
LomustineThe metabolism of Lomustine can be decreased when combined with Abiraterone.
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Abiraterone.
LopinavirThe metabolism of Abiraterone can be decreased when combined with Lopinavir.
LoratadineThe serum concentration of Loratadine can be increased when it is combined with Abiraterone.
LorcaserinThe serum concentration of Lorcaserin can be increased when it is combined with Abiraterone.
LornoxicamThe metabolism of Lornoxicam can be decreased when combined with Abiraterone.
LosartanThe serum concentration of Losartan can be increased when it is combined with Abiraterone.
LovastatinThe metabolism of Abiraterone can be decreased when combined with Lovastatin.
LuliconazoleThe serum concentration of Abiraterone can be increased when it is combined with Luliconazole.
LumiracoxibThe serum concentration of Lumiracoxib can be increased when it is combined with Abiraterone.
MacitentanThe metabolism of Macitentan can be decreased when combined with Abiraterone.
MalathionThe serum concentration of Malathion can be increased when it is combined with Abiraterone.
MaprotilineThe serum concentration of Maprotiline can be increased when it is combined with Abiraterone.
Mefenamic acidThe serum concentration of Mefenamic acid can be increased when it is combined with Abiraterone.
MelatoninThe serum concentration of Melatonin can be increased when it is combined with Abiraterone.
MeloxicamThe serum concentration of Meloxicam can be increased when it is combined with Abiraterone.
MenadioneThe serum concentration of Menadione can be increased when it is combined with Abiraterone.
MephenytoinThe serum concentration of Mephenytoin can be increased when it is combined with Abiraterone.
MeprobamateThe metabolism of Meprobamate can be decreased when combined with Abiraterone.
MequitazineThe metabolism of Mequitazine can be decreased when combined with Abiraterone.
MesoridazineThe metabolism of Mesoridazine can be decreased when combined with Abiraterone.
MestranolThe metabolism of Mestranol can be decreased when combined with Abiraterone.
MethadoneThe serum concentration of Methadone can be increased when it is combined with Abiraterone.
MethamphetamineThe metabolism of Methamphetamine can be decreased when combined with Abiraterone.
MethotrimeprazineThe metabolism of Methotrimeprazine can be decreased when combined with Abiraterone.
MethoxyfluraneThe serum concentration of Methoxyflurane can be increased when it is combined with Abiraterone.
MethsuximideThe metabolism of Methsuximide can be decreased when combined with Abiraterone.
MethylphenidateThe metabolism of Methylphenidate can be decreased when combined with Abiraterone.
MethylphenobarbitalThe metabolism of Methylphenobarbital can be decreased when combined with Abiraterone.
MethyprylonThe metabolism of Methyprylon can be decreased when combined with Abiraterone.
MetoclopramideThe metabolism of Metoclopramide can be decreased when combined with Abiraterone.
MetoprololThe metabolism of Metoprolol can be decreased when combined with Abiraterone.
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Abiraterone.
MexiletineThe serum concentration of Mexiletine can be increased when it is combined with Abiraterone.
MianserinThe serum concentration of Mianserin can be increased when it is combined with Abiraterone.
MifepristoneThe metabolism of Abiraterone can be decreased when combined with Mifepristone.
MinaprineThe metabolism of Minaprine can be decreased when combined with Abiraterone.
MirabegronThe metabolism of Mirabegron can be decreased when combined with Abiraterone.
MirtazapineThe serum concentration of Mirtazapine can be increased when it is combined with Abiraterone.
MitotaneThe serum concentration of Abiraterone can be decreased when it is combined with Mitotane.
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Abiraterone.
ModafinilThe serum concentration of Abiraterone can be decreased when it is combined with Modafinil.
MontelukastThe metabolism of Montelukast can be decreased when combined with Abiraterone.
MorphineThe serum concentration of Morphine can be increased when it is combined with Abiraterone.
muraglitazarThe serum concentration of muraglitazar can be increased when it is combined with Abiraterone.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Abiraterone.
NabumetoneThe serum concentration of Nabumetone can be increased when it is combined with Abiraterone.
NafcillinThe serum concentration of Abiraterone can be decreased when it is combined with Nafcillin.
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Abiraterone.
NaproxenThe serum concentration of Naproxen can be increased when it is combined with Abiraterone.
NateglinideThe metabolism of Nateglinide can be decreased when combined with Abiraterone.
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Abiraterone.
NefazodoneThe metabolism of Abiraterone can be decreased when combined with Nefazodone.
NelfinavirThe metabolism of Abiraterone can be decreased when combined with Nelfinavir.
NetupitantThe serum concentration of Abiraterone can be increased when it is combined with Netupitant.
NetupitantThe metabolism of Netupitant can be decreased when combined with Abiraterone.
NevirapineThe serum concentration of Abiraterone can be decreased when it is combined with Nevirapine.
NevirapineThe metabolism of Nevirapine can be decreased when combined with Abiraterone.
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Abiraterone.
NicergolineThe metabolism of Nicergoline can be decreased when combined with Abiraterone.
NiclosamideThe metabolism of Niclosamide can be decreased when combined with Abiraterone.
NicotineThe serum concentration of Nicotine can be increased when it is combined with Abiraterone.
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Abiraterone.
NilotinibThe metabolism of Abiraterone can be decreased when combined with Nilotinib.
NilutamideThe metabolism of Nilutamide can be decreased when combined with Abiraterone.
Nitric OxideThe serum concentration of Nitric Oxide can be increased when it is combined with Abiraterone.
NitrofuralThe metabolism of Nitrofural can be decreased when combined with Abiraterone.
NortriptylineThe serum concentration of Nortriptyline can be increased when it is combined with Abiraterone.
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Abiraterone.
OlaparibThe metabolism of Abiraterone can be decreased when combined with Olaparib.
OlodaterolThe serum concentration of Olodaterol can be increased when it is combined with Abiraterone.
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Abiraterone.
OmeprazoleThe serum concentration of Omeprazole can be increased when it is combined with Abiraterone.
OndansetronThe serum concentration of Ondansetron can be increased when it is combined with Abiraterone.
OsimertinibThe serum concentration of Abiraterone can be increased when it is combined with Osimertinib.
OspemifeneThe metabolism of Ospemifene can be decreased when combined with Abiraterone.
OuabainOuabain may decrease the cardiotoxic activities of Abiraterone.
OxaliplatinThe serum concentration of Oxaliplatin can be increased when it is combined with Abiraterone.
OxaprozinThe metabolism of Oxaprozin can be decreased when combined with Abiraterone.
OxiconazoleThe metabolism of Oxiconazole can be decreased when combined with Abiraterone.
OxtriphyllineThe serum concentration of Oxtriphylline can be increased when it is combined with Abiraterone.
OxycodoneThe metabolism of Oxycodone can be decreased when combined with Abiraterone.
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Abiraterone.
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Abiraterone.
PaclitaxelThe risk or severity of adverse effects can be increased when Paclitaxel is combined with Abiraterone.
PalbociclibThe serum concentration of Abiraterone can be increased when it is combined with Palbociclib.
PalonosetronThe serum concentration of Palonosetron can be increased when it is combined with Abiraterone.
PantoprazoleThe serum concentration of Pantoprazole can be increased when it is combined with Abiraterone.
ParamethadioneThe serum concentration of Paramethadione can be increased when it is combined with Abiraterone.
ParecoxibThe metabolism of Parecoxib can be decreased when combined with Abiraterone.
ParoxetineThe metabolism of Paroxetine can be decreased when combined with Abiraterone.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Abiraterone.
PentamidineThe serum concentration of Pentamidine can be increased when it is combined with Abiraterone.
PentobarbitalThe serum concentration of Abiraterone can be decreased when it is combined with Pentobarbital.
PentobarbitalThe metabolism of Pentobarbital can be decreased when combined with Abiraterone.
PentoxifyllineThe serum concentration of Pentoxifylline can be increased when it is combined with Abiraterone.
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Abiraterone.
PerphenazineThe serum concentration of Perphenazine can be increased when it is combined with Abiraterone.
PethidineThe metabolism of Pethidine can be decreased when combined with Abiraterone.
PhenacetinThe serum concentration of Phenacetin can be increased when it is combined with Abiraterone.
PhenforminThe metabolism of Phenformin can be decreased when combined with Abiraterone.
PhenobarbitalThe serum concentration of Abiraterone can be decreased when it is combined with Phenobarbital.
PhenobarbitalThe metabolism of Phenobarbital can be decreased when combined with Abiraterone.
PhenprocoumonThe serum concentration of Phenprocoumon can be increased when it is combined with Abiraterone.
PhenylbutazoneThe metabolism of Phenylbutazone can be decreased when combined with Abiraterone.
PhenytoinThe serum concentration of Abiraterone can be decreased when it is combined with Phenytoin.
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Abiraterone.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Abiraterone.
PindololThe metabolism of Pindolol can be decreased when combined with Abiraterone.
PioglitazoneThe serum concentration of Pioglitazone can be increased when it is combined with Abiraterone.
PiperazineThe metabolism of Piperazine can be decreased when combined with Abiraterone.
PipotiazineThe serum concentration of Pipotiazine can be increased when it is combined with Abiraterone.
PirfenidoneThe serum concentration of Pirfenidone can be increased when it is combined with Abiraterone.
PiroxicamThe serum concentration of Piroxicam can be increased when it is combined with Abiraterone.
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Abiraterone.
PodofiloxThe metabolism of Podofilox can be decreased when combined with Abiraterone.
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Abiraterone.
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Abiraterone.
PosaconazoleThe metabolism of Abiraterone can be decreased when combined with Posaconazole.
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Abiraterone.
PravastatinThe metabolism of Pravastatin can be decreased when combined with Abiraterone.
PraziquantelThe serum concentration of Praziquantel can be increased when it is combined with Abiraterone.
PrimaquineThe serum concentration of Primaquine can be increased when it is combined with Abiraterone.
PrimidoneThe serum concentration of Abiraterone can be decreased when it is combined with Primidone.
PrimidoneThe metabolism of Primidone can be decreased when combined with Abiraterone.
ProcainamideThe metabolism of Procainamide can be decreased when combined with Abiraterone.
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Abiraterone.
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Abiraterone.
ProguanilThe serum concentration of Proguanil can be increased when it is combined with Abiraterone.
PromazineThe serum concentration of Promazine can be increased when it is combined with Abiraterone.
PromethazineThe metabolism of Promethazine can be decreased when combined with Abiraterone.
PropafenoneThe serum concentration of Abiraterone can be increased when it is combined with Propafenone.
PropofolThe serum concentration of Propofol can be increased when it is combined with Abiraterone.
PropranololThe serum concentration of Propranolol can be increased when it is combined with Abiraterone.
ProtriptylineThe metabolism of Protriptyline can be decreased when combined with Abiraterone.
PseudoephedrineThe metabolism of Pseudoephedrine can be decreased when combined with Abiraterone.
PyrazinamideThe serum concentration of Pyrazinamide can be increased when it is combined with Abiraterone.
QuazepamThe metabolism of Quazepam can be decreased when combined with Abiraterone.
QuetiapineThe metabolism of Quetiapine can be decreased when combined with Abiraterone.
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Abiraterone.
QuinineThe serum concentration of Quinine can be increased when it is combined with Abiraterone.
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Abiraterone.
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Abiraterone.
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Abiraterone.
RanolazineThe metabolism of Abiraterone can be decreased when combined with Ranolazine.
RasagilineThe serum concentration of Rasagiline can be increased when it is combined with Abiraterone.
RemoxiprideThe metabolism of Remoxipride can be decreased when combined with Abiraterone.
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Abiraterone.
repinotanThe metabolism of repinotan can be decreased when combined with Abiraterone.
ResveratrolThe serum concentration of Resveratrol can be increased when it is combined with Abiraterone.
RifabutinThe serum concentration of Rifabutin can be increased when it is combined with Abiraterone.
RifabutinThe serum concentration of Abiraterone can be decreased when it is combined with Rifabutin.
RifampicinThe serum concentration of Abiraterone can be decreased when it is combined with Rifampicin.
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Abiraterone.
RifapentineThe serum concentration of Abiraterone can be decreased when it is combined with Rifapentine.
RiluzoleThe serum concentration of Riluzole can be increased when it is combined with Abiraterone.
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Abiraterone.
RisperidoneThe metabolism of Risperidone can be decreased when combined with Abiraterone.
RitonavirThe serum concentration of Ritonavir can be increased when it is combined with Abiraterone.
RitonavirThe metabolism of Abiraterone can be decreased when combined with Ritonavir.
RizatriptanThe serum concentration of Rizatriptan can be increased when it is combined with Abiraterone.
RofecoxibThe serum concentration of Rofecoxib can be increased when it is combined with Abiraterone.
RomidepsinThe metabolism of Romidepsin can be decreased when combined with Abiraterone.
RopiniroleThe serum concentration of Ropinirole can be increased when it is combined with Abiraterone.
RopivacaineThe serum concentration of Ropivacaine can be increased when it is combined with Abiraterone.
RosiglitazoneThe serum concentration of Rosiglitazone can be increased when it is combined with Abiraterone.
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Abiraterone.
RotigotineThe serum concentration of Rotigotine can be increased when it is combined with Abiraterone.
Salicylic acidThe metabolism of Salicylic acid can be decreased when combined with Abiraterone.
SaquinavirThe metabolism of Abiraterone can be decreased when combined with Saquinavir.
SelegilineThe serum concentration of Selegiline can be increased when it is combined with Abiraterone.
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Abiraterone.
SeratrodastThe serum concentration of Seratrodast can be increased when it is combined with Abiraterone.
SertindoleThe metabolism of Sertindole can be decreased when combined with Abiraterone.
SertralineThe serum concentration of Sertraline can be increased when it is combined with Abiraterone.
SildenafilThe metabolism of Abiraterone can be decreased when combined with Sildenafil.
SiltuximabThe serum concentration of Abiraterone can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Abiraterone can be increased when it is combined with Simeprevir.
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Abiraterone.
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Abiraterone.
SitaxentanThe metabolism of Sitaxentan can be decreased when combined with Abiraterone.
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Abiraterone.
SparteineThe metabolism of Sparteine can be decreased when combined with Abiraterone.
SpironolactoneThe therapeutic efficacy of Abiraterone can be decreased when used in combination with Spironolactone.
St. John's WortThe serum concentration of Abiraterone can be decreased when it is combined with St. John's Wort.
StiripentolThe serum concentration of Abiraterone can be increased when it is combined with Stiripentol.
SulfadiazineThe serum concentration of Sulfadiazine can be increased when it is combined with Abiraterone.
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Abiraterone.
SulfamoxoleThe metabolism of Sulfamoxole can be decreased when combined with Abiraterone.
SulfinpyrazoneThe serum concentration of Sulfinpyrazone can be increased when it is combined with Abiraterone.
SulfisoxazoleThe metabolism of Abiraterone can be decreased when combined with Sulfisoxazole.
SuprofenThe metabolism of Suprofen can be decreased when combined with Abiraterone.
TacrineThe serum concentration of Tacrine can be increased when it is combined with Abiraterone.
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Abiraterone.
TamsulosinThe metabolism of Tamsulosin can be decreased when combined with Abiraterone.
TapentadolThe metabolism of Tapentadol can be decreased when combined with Abiraterone.
TasimelteonThe serum concentration of Tasimelteon can be increased when it is combined with Abiraterone.
TazaroteneThe serum concentration of Tazarotene can be increased when it is combined with Abiraterone.
TegaserodThe metabolism of Tegaserod can be decreased when combined with Abiraterone.
TelaprevirThe metabolism of Abiraterone can be decreased when combined with Telaprevir.
TelithromycinThe serum concentration of Telithromycin can be increased when it is combined with Abiraterone.
TelithromycinThe metabolism of Abiraterone can be decreased when combined with Telithromycin.
TemafloxacinThe serum concentration of Temafloxacin can be increased when it is combined with Abiraterone.
TemazepamThe serum concentration of Temazepam can be increased when it is combined with Abiraterone.
TeniposideThe metabolism of Teniposide can be decreased when combined with Abiraterone.
TenoxicamThe metabolism of Tenoxicam can be decreased when combined with Abiraterone.
TerbinafineThe serum concentration of Terbinafine can be increased when it is combined with Abiraterone.
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Abiraterone.
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Abiraterone.
TestosteroneThe serum concentration of Testosterone can be increased when it is combined with Abiraterone.
TetrabenazineThe metabolism of Tetrabenazine can be decreased when combined with Abiraterone.
ThalidomideThe serum concentration of Thalidomide can be increased when it is combined with Abiraterone.
TheobromineThe serum concentration of Theobromine can be increased when it is combined with Abiraterone.
TheophyllineThe serum concentration of Theophylline can be increased when it is combined with Abiraterone.
ThiabendazoleThe serum concentration of Thiabendazole can be increased when it is combined with Abiraterone.
ThiamylalThe metabolism of Thiamylal can be decreased when combined with Abiraterone.
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Abiraterone.
ThiothixeneThe serum concentration of Thiothixene can be increased when it is combined with Abiraterone.
TiclopidineThe metabolism of Abiraterone can be decreased when combined with Ticlopidine.
TimololThe metabolism of Timolol can be decreased when combined with Abiraterone.
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Abiraterone.
TipranavirThe metabolism of Tipranavir can be decreased when combined with Abiraterone.
TizanidineThe serum concentration of Tizanidine can be increased when it is combined with Abiraterone.
TocilizumabThe serum concentration of Abiraterone can be decreased when it is combined with Tocilizumab.
TofacitinibThe metabolism of Tofacitinib can be decreased when combined with Abiraterone.
TolbutamideThe serum concentration of Tolbutamide can be increased when it is combined with Abiraterone.
TolterodineThe metabolism of Tolterodine can be decreased when combined with Abiraterone.
TorasemideThe serum concentration of Torasemide can be increased when it is combined with Abiraterone.
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Abiraterone.
TrabectedinThe metabolism of Trabectedin can be decreased when combined with Abiraterone.
TramadolThe therapeutic efficacy of Tramadol can be decreased when used in combination with Abiraterone.
TrastuzumabTrastuzumab may increase the cardiotoxic activities of Abiraterone.
TrazodoneThe metabolism of Trazodone can be decreased when combined with Abiraterone.
TreprostinilThe metabolism of Treprostinil can be decreased when combined with Abiraterone.
TretinoinThe serum concentration of Tretinoin can be increased when it is combined with Abiraterone.
TriamtereneThe serum concentration of Triamterene can be increased when it is combined with Abiraterone.
TrifluoperazineThe serum concentration of Trifluoperazine can be increased when it is combined with Abiraterone.
TrimethadioneThe serum concentration of Trimethadione can be increased when it is combined with Abiraterone.
TrimethoprimThe serum concentration of Trimethoprim can be increased when it is combined with Abiraterone.
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Abiraterone.
TroglitazoneThe serum concentration of Troglitazone can be increased when it is combined with Abiraterone.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Abiraterone.
UmeclidiniumThe metabolism of Umeclidinium can be decreased when combined with Abiraterone.
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Abiraterone.
Valproic AcidThe metabolism of Valproic Acid can be decreased when combined with Abiraterone.
ValsartanThe metabolism of Valsartan can be decreased when combined with Abiraterone.
VenlafaxineThe metabolism of Abiraterone can be decreased when combined with Venlafaxine.
VerapamilThe serum concentration of Verapamil can be increased when it is combined with Abiraterone.
VerapamilThe metabolism of Abiraterone can be decreased when combined with Verapamil.
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Abiraterone.
VilazodoneThe metabolism of Vilazodone can be decreased when combined with Abiraterone.
VinblastineThe metabolism of Vinblastine can be decreased when combined with Abiraterone.
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Abiraterone.
VismodegibThe metabolism of Vismodegib can be decreased when combined with Abiraterone.
VoriconazoleThe metabolism of Abiraterone can be decreased when combined with Voriconazole.
VortioxetineThe serum concentration of Vortioxetine can be increased when it is combined with Abiraterone.
WarfarinThe serum concentration of Warfarin can be increased when it is combined with Abiraterone.
XimelagatranThe metabolism of Ximelagatran can be decreased when combined with Abiraterone.
YohimbineThe metabolism of Yohimbine can be decreased when combined with Abiraterone.
ZafirlukastThe serum concentration of Zafirlukast can be increased when it is combined with Abiraterone.
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Abiraterone.
ZaltoprofenThe metabolism of Zaltoprofen can be decreased when combined with Abiraterone.
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Abiraterone.
ZileutonThe serum concentration of Zileuton can be increased when it is combined with Abiraterone.
ZiprasidoneThe serum concentration of Ziprasidone can be increased when it is combined with Abiraterone.
ZiprasidoneThe metabolism of Abiraterone can be decreased when combined with Ziprasidone.
ZolmitriptanThe serum concentration of Zolmitriptan can be increased when it is combined with Abiraterone.
ZolpidemThe serum concentration of Zolpidem can be increased when it is combined with Abiraterone.
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Abiraterone.
ZuclopenthixolThe metabolism of Zuclopenthixol can be decreased when combined with Abiraterone.
Food Interactions
  • Food and high fat meals increases the drug exposure 4.4-fold. It is suggested that abiraterone is taken on an empty stomach.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Steroid 17-alpha-monooxygenase activity
Specific Function:
Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.
Gene Name:
CYP17A1
Uniprot ID:
P05093
Molecular Weight:
57369.995 Da
References
  1. Vogiatzi P, Claudio PP: Efficacy of abiraterone acetate in post-docetaxel castration-resistant prostate cancer. Expert Rev Anticancer Ther. 2010 Jul;10(7):1027-30. doi: 10.1586/era.10.84. [PubMed:20645691 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Beckett RD, Rodeffer KM, Snodgrass R: Abiraterone for the treatment of metastatic castrate-resistant prostate cancer. Ann Pharmacother. 2012 Jul-Aug;46(7-8):1016-24. doi: 10.1345/aph.1Q758. Epub 2012 Jun 19. [PubMed:22714819 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Sulfotransferase activity
Specific Function:
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands.
Gene Name:
SULT2A1
Uniprot ID:
Q06520
Molecular Weight:
33779.57 Da
References
  1. Beckett RD, Rodeffer KM, Snodgrass R: Abiraterone for the treatment of metastatic castrate-resistant prostate cancer. Ann Pharmacother. 2012 Jul-Aug;46(7-8):1016-24. doi: 10.1345/aph.1Q758. Epub 2012 Jun 19. [PubMed:22714819 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Chi KN, Tolcher A, Lee P, Rosen PJ, Kollmannsberger CK, Papadopoulos KP, Patnaik A, Molina A, Jiao J, Pankras C, Kaiser B, Bernard A, Tran N, Acharya M: Effect of abiraterone acetate plus prednisone on the pharmacokinetics of dextromethorphan and theophylline in patients with metastatic castration-resistant prostate cancer. Cancer Chemother Pharmacol. 2013 Jan;71(1):237-44. doi: 10.1007/s00280-012-2001-0. Epub 2012 Oct 12. [PubMed:23064959 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da

Carriers

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Toxic substance binding
Specific Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
Gene Name:
ALB
Uniprot ID:
P02768
Molecular Weight:
69365.94 Da
References
  1. Ryan CJ, Cheng ML: Abiraterone acetate for the treatment of prostate cancer. Expert Opin Pharmacother. 2013 Jan;14(1):91-6. doi: 10.1517/14656566.2013.745852. Epub 2012 Nov 30. [PubMed:23199349 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Not Available
Specific Function:
Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
Gene Name:
ORM1
Uniprot ID:
P02763
Molecular Weight:
23511.38 Da
References
  1. Ryan CJ, Cheng ML: Abiraterone acetate for the treatment of prostate cancer. Expert Opin Pharmacother. 2013 Jan;14(1):91-6. doi: 10.1517/14656566.2013.745852. Epub 2012 Nov 30. [PubMed:23199349 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Transporter activity
Specific Function:
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.
Gene Name:
ABCC1
Uniprot ID:
P33527
Molecular Weight:
171589.5 Da
References
  1. Beckett RD, Rodeffer KM, Snodgrass R: Abiraterone for the treatment of metastatic castrate-resistant prostate cancer. Ann Pharmacother. 2012 Jul-Aug;46(7-8):1016-24. doi: 10.1345/aph.1Q758. Epub 2012 Jun 19. [PubMed:22714819 ]
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Drug created on November 18, 2007 11:28 / Updated on September 27, 2016 02:27