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Identification
NameMitotane
Accession NumberDB00648  (APRD00494)
TypeSmall Molecule
GroupsApproved
DescriptionA derivative of the insecticide dichlorodiphenyldichloroethane that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression. [PubChem]
Structure
Thumb
Synonyms
Lysodren
Mitotan
Mitotane
Mitotano
Mitotanum
Piprine-DDD, O-
External Identifiers
  • CB 313
  • NSC 38721
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Lysodrentablet500 mg/1oralE.R. Squibb & Sons, L.L.C.2009-06-01Not applicableUs
Lysodrentablet500 mgoralBristol Myers Squibb Canada1979-12-31Not applicableCanada
LysodrenTablet500 mgOral useLaboratoire HRA Pharma2004-04-28Not applicableEu
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
LisodrenBristol-Myers Squibb
OpeprimYakult Honsha
Brand mixturesNot Available
SaltsNot Available
Categories
UNII78E4J5IB5J
CAS number53-19-0
WeightAverage: 320.041
Monoisotopic: 317.953661148
Chemical FormulaC14H10Cl4
InChI KeyInChIKey=JWBOIMRXGHLCPP-UHFFFAOYSA-N
InChI
InChI=1S/C14H10Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8,13-14H
IUPAC Name
1-chloro-4-[2,2-dichloro-1-(2-chlorophenyl)ethyl]benzene
SMILES
ClC(Cl)C(C1=CC=C(Cl)C=C1)C1=CC=CC=C1Cl
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassDiphenylmethanes
Direct ParentDiphenylmethanes
Alternative Parents
Substituents
  • Diphenylmethane
  • Halobenzene
  • Chlorobenzene
  • Aryl halide
  • Aryl chloride
  • Hydrocarbon derivative
  • Organochloride
  • Organohalogen compound
  • Alkyl halide
  • Alkyl chloride
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationFor treatment of inoperable adrenocortical tumours; Cushing's syndrome
PharmacodynamicsMitotane is an oral chemotherapeutic agent indicated in the treatment of inoperable adrenal cortical carcinoma of both functional and nonfunctional types. Mitotane can best be described as an adrenal cytotoxic agent, although it can cause adrenal inhibition, apparently without cellular destruction. The administration of Mitotane alters the extra-adrenal metabolism of cortisol in man; leading to a reduction in measurable 17-hydroxy corticosteroids, even though plasma levels of corticosteroids do not fall. The drug apparently causes increased formation of 6-B-hydroxyl cortisol.
Mechanism of actionIts biochemical mechanism of action is unknown, although data are available to suggest that the drug modifies the peripheral metabolism of steroids as well as directly suppressing the adrenal cortex.
Related Articles
AbsorptionAbout 40% oral Lysodren is absorbed
Volume of distributionNot Available
Protein binding6%
Metabolism

Hepatic and renal

Route of eliminationA variable amount of metabolite (1%-17%) is excreted in the bile and the balance is apparently stored in the tissues.
Half life18-159 days
ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9942
Blood Brain Barrier+0.9905
Caco-2 permeable+0.8815
P-glycoprotein substrateNon-substrate0.8053
P-glycoprotein inhibitor INon-inhibitor0.9004
P-glycoprotein inhibitor IINon-inhibitor0.988
Renal organic cation transporterNon-inhibitor0.7959
CYP450 2C9 substrateNon-substrate0.7899
CYP450 2D6 substrateNon-substrate0.818
CYP450 3A4 substrateNon-substrate0.7045
CYP450 1A2 substrateInhibitor0.9542
CYP450 2C9 inhibitorInhibitor0.7241
CYP450 2D6 inhibitorNon-inhibitor0.9349
CYP450 2C19 inhibitorInhibitor0.8993
CYP450 3A4 inhibitorNon-inhibitor0.8629
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.8
Ames testNon AMES toxic0.9751
CarcinogenicityNon-carcinogens0.575
BiodegradationNot ready biodegradable0.9596
Rat acute toxicity2.1911 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9221
hERG inhibition (predictor II)Non-inhibitor0.875
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Bristol myers squibb
Packagers
Dosage forms
FormRouteStrength
Tabletoral500 mg/1
Tabletoral500 mg
TabletOral use500 mg
Prices
Unit descriptionCostUnit
Mitotane powder7.75USD g
Lysodren 500 mg tablet5.13USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point77 °CPhysProp
water solubility0.1 mg/L (at 25 °C)BIGGAR,JW & RIGGS,RI (1974)
logP6Not Available
logS-6.51ADME Research, USCD
Predicted Properties
PropertyValueSource
Water Solubility9.42e-06 mg/mLALOGPS
logP6.08ALOGPS
logP6.11ChemAxon
logS-7.5ALOGPS
Physiological Charge0ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity79.97 m3·mol-1ChemAxon
Polarizability29.93 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (8.84 KB)
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
MSMass Spectrum (Electron Ionization)splash10-000i-2690000000-770065ddc57899130a31View in MoNA
1D NMR1H NMR SpectrumNot Available
1D NMR13C NMR SpectrumNot Available
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesL01XX23
AHFS Codes
  • 10:00.00
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (57 KB)
Interactions
Drug Interactions
Drug
4-AndrostenedioneThe serum concentration of 4-Androstenedione can be decreased when it is combined with Mitotane.
AbirateroneThe serum concentration of Abiraterone can be decreased when it is combined with Mitotane.
AcenocoumarolThe serum concentration of Acenocoumarol can be decreased when it is combined with Mitotane.
AcetaminophenThe serum concentration of Acetaminophen can be decreased when it is combined with Mitotane.
AcetyldigitoxinAcetyldigitoxin may decrease the cardiotoxic activities of Mitotane.
AdinazolamThe serum concentration of Adinazolam can be decreased when it is combined with Mitotane.
AlbendazoleThe serum concentration of Albendazole can be decreased when it is combined with Mitotane.
AlclometasoneThe serum concentration of Alclometasone can be decreased when it is combined with Mitotane.
AldosteroneThe serum concentration of Aldosterone can be decreased when it is combined with Mitotane.
AlfentanilThe serum concentration of Alfentanil can be decreased when it is combined with Mitotane.
AlfuzosinThe serum concentration of Alfuzosin can be decreased when it is combined with Mitotane.
AliskirenThe serum concentration of Aliskiren can be decreased when it is combined with Mitotane.
AllylestrenolThe serum concentration of Allylestrenol can be decreased when it is combined with Mitotane.
AlmotriptanThe serum concentration of Almotriptan can be decreased when it is combined with Mitotane.
AlogliptinThe serum concentration of Alogliptin can be decreased when it is combined with Mitotane.
AlosetronThe serum concentration of Alosetron can be decreased when it is combined with Mitotane.
AlprazolamThe serum concentration of Alprazolam can be decreased when it is combined with Mitotane.
AmbrisentanThe serum concentration of Ambrisentan can be decreased when it is combined with Mitotane.
AmbroxolThe serum concentration of Ambroxol can be decreased when it is combined with Mitotane.
AmcinonideThe serum concentration of Amcinonide can be decreased when it is combined with Mitotane.
AminophenazoneThe serum concentration of Aminophenazone can be decreased when it is combined with Mitotane.
AminophyllineThe serum concentration of Aminophylline can be decreased when it is combined with Mitotane.
AmiodaroneThe serum concentration of Amiodarone can be decreased when it is combined with Mitotane.
AmitriptylineThe serum concentration of Amitriptyline can be decreased when it is combined with Mitotane.
AmlodipineThe serum concentration of Amlodipine can be decreased when it is combined with Mitotane.
AmprenavirThe serum concentration of Amprenavir can be decreased when it is combined with Mitotane.
AntipyrineThe serum concentration of Antipyrine can be decreased when it is combined with Mitotane.
ApixabanThe serum concentration of Apixaban can be decreased when it is combined with Mitotane.
ApremilastThe serum concentration of Apremilast can be decreased when it is combined with Mitotane.
AprepitantThe serum concentration of Aprepitant can be decreased when it is combined with Mitotane.
ArgatrobanThe serum concentration of Argatroban can be decreased when it is combined with Mitotane.
AripiprazoleThe serum concentration of Aripiprazole can be decreased when it is combined with Mitotane.
ArtemetherThe serum concentration of the active metabolites of Artemether can be reduced when Artemether is used in combination with Mitotane resulting in a loss in efficacy.
AsenapineThe serum concentration of Asenapine can be decreased when it is combined with Mitotane.
AstemizoleThe serum concentration of Astemizole can be decreased when it is combined with Mitotane.
AtazanavirThe serum concentration of Atazanavir can be decreased when it is combined with Mitotane.
AtorvastatinThe serum concentration of Atorvastatin can be decreased when it is combined with Mitotane.
AvanafilThe serum concentration of Avanafil can be decreased when it is combined with Mitotane.
AxitinibThe serum concentration of Axitinib can be decreased when it is combined with Mitotane.
AzelastineThe serum concentration of Azelastine can be decreased when it is combined with Mitotane.
AzithromycinThe serum concentration of Azithromycin can be decreased when it is combined with Mitotane.
BanoxantroneThe serum concentration of Banoxantrone can be decreased when it is combined with Mitotane.
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be decreased when it is combined with Mitotane.
BedaquilineThe serum concentration of Bedaquiline can be decreased when it is combined with Mitotane.
BenzphetamineThe serum concentration of Benzphetamine can be decreased when it is combined with Mitotane.
Benzyl alcoholThe serum concentration of Benzyl alcohol can be decreased when it is combined with Mitotane.
BetamethasoneThe serum concentration of Betamethasone can be decreased when it is combined with Mitotane.
BevacizumabBevacizumab may increase the cardiotoxic activities of Mitotane.
BexaroteneThe serum concentration of Bexarotene can be decreased when it is combined with Mitotane.
BezafibrateThe serum concentration of Bezafibrate can be decreased when it is combined with Mitotane.
BicalutamideThe serum concentration of Bicalutamide can be decreased when it is combined with Mitotane.
BisoprololThe serum concentration of Bisoprolol can be decreased when it is combined with Mitotane.
BoceprevirThe serum concentration of Boceprevir can be decreased when it is combined with Mitotane.
BortezomibThe serum concentration of Bortezomib can be decreased when it is combined with Mitotane.
BosentanThe serum concentration of Bosentan can be decreased when it is combined with Mitotane.
BosutinibThe serum concentration of Bosutinib can be decreased when it is combined with Mitotane.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be decreased when it is combined with Mitotane.
BrexpiprazoleThe serum concentration of Brexpiprazole can be decreased when it is combined with Mitotane.
BrinzolamideThe serum concentration of Brinzolamide can be decreased when it is combined with Mitotane.
BromazepamThe serum concentration of Bromazepam can be decreased when it is combined with Mitotane.
BromocriptineThe serum concentration of Bromocriptine can be decreased when it is combined with Mitotane.
BrompheniramineThe serum concentration of Brompheniramine can be decreased when it is combined with Mitotane.
BudesonideThe serum concentration of Budesonide can be decreased when it is combined with Mitotane.
BupivacaineThe serum concentration of Bupivacaine can be decreased when it is combined with Mitotane.
BuprenorphineThe serum concentration of Buprenorphine can be decreased when it is combined with Mitotane.
BupropionThe serum concentration of Bupropion can be decreased when it is combined with Mitotane.
BuspironeThe serum concentration of Buspirone can be decreased when it is combined with Mitotane.
BusulfanThe serum concentration of Busulfan can be decreased when it is combined with Mitotane.
CabazitaxelThe serum concentration of Cabazitaxel can be decreased when it is combined with Mitotane.
CabazitaxelThe risk or severity of adverse effects can be increased when Cabazitaxel is combined with Mitotane.
CabergolineThe serum concentration of Cabergoline can be decreased when it is combined with Mitotane.
CabozantinibThe serum concentration of Cabozantinib can be decreased when it is combined with Mitotane.
CaffeineThe serum concentration of Caffeine can be decreased when it is combined with Mitotane.
CalcitriolThe serum concentration of Calcitriol can be decreased when it is combined with Mitotane.
CanagliflozinThe serum concentration of Canagliflozin can be decreased when it is combined with Mitotane.
CannabidiolThe serum concentration of Cannabidiol can be decreased when it is combined with Mitotane.
CarbamazepineThe serum concentration of Carbamazepine can be decreased when it is combined with Mitotane.
CarbinoxamineThe serum concentration of Carbinoxamine can be decreased when it is combined with Mitotane.
CariprazineThe serum concentration of Cariprazine can be decreased when it is combined with Mitotane.
CarvedilolThe serum concentration of Carvedilol can be decreased when it is combined with Mitotane.
CelecoxibThe serum concentration of Celecoxib can be decreased when it is combined with Mitotane.
CeliprololThe serum concentration of Celiprolol can be decreased when it is combined with Mitotane.
CephalexinThe serum concentration of Cephalexin can be decreased when it is combined with Mitotane.
CeritinibThe serum concentration of Ceritinib can be decreased when it is combined with Mitotane.
CerivastatinThe serum concentration of Cerivastatin can be decreased when it is combined with Mitotane.
CevimelineThe serum concentration of Cevimeline can be decreased when it is combined with Mitotane.
Chenodeoxycholic acidThe serum concentration of Chenodeoxycholic acid can be decreased when it is combined with Mitotane.
ChlordiazepoxideThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Mitotane.
ChloroquineThe serum concentration of Chloroquine can be decreased when it is combined with Mitotane.
ChlorphenamineThe serum concentration of Chlorphenamine can be decreased when it is combined with Mitotane.
ChlorpromazineThe serum concentration of Chlorpromazine can be decreased when it is combined with Mitotane.
ChlorzoxazoneThe serum concentration of Chlorzoxazone can be decreased when it is combined with Mitotane.
CholecalciferolThe serum concentration of Cholecalciferol can be decreased when it is combined with Mitotane.
CiclesonideThe serum concentration of Ciclesonide can be decreased when it is combined with Mitotane.
CilostazolThe serum concentration of Cilostazol can be decreased when it is combined with Mitotane.
CinacalcetThe serum concentration of Cinacalcet can be decreased when it is combined with Mitotane.
CisaprideThe serum concentration of Cisapride can be decreased when it is combined with Mitotane.
CitalopramThe serum concentration of Citalopram can be decreased when it is combined with Mitotane.
ClarithromycinThe serum concentration of Clarithromycin can be decreased when it is combined with Mitotane.
ClindamycinThe serum concentration of Clindamycin can be decreased when it is combined with Mitotane.
ClobazamThe serum concentration of Clobazam can be decreased when it is combined with Mitotane.
Clobetasol propionateThe serum concentration of Clobetasol propionate can be decreased when it is combined with Mitotane.
ClocortoloneThe serum concentration of Clocortolone can be decreased when it is combined with Mitotane.
ClofazimineThe serum concentration of Clofazimine can be decreased when it is combined with Mitotane.
ClofibrateThe serum concentration of Clofibrate can be decreased when it is combined with Mitotane.
clomethiazoleThe serum concentration of clomethiazole can be decreased when it is combined with Mitotane.
ClomipramineThe serum concentration of Clomipramine can be decreased when it is combined with Mitotane.
ClonazepamThe serum concentration of Clonazepam can be decreased when it is combined with Mitotane.
ClonidineThe serum concentration of Clonidine can be decreased when it is combined with Mitotane.
ClopidogrelThe serum concentration of Clopidogrel can be decreased when it is combined with Mitotane.
ClorazepateThe serum concentration of Clorazepate can be decreased when it is combined with Mitotane.
ClotiazepamThe serum concentration of Clotiazepam can be decreased when it is combined with Mitotane.
ClozapineThe serum concentration of Clozapine can be decreased when it is combined with Mitotane.
CobimetinibThe serum concentration of Cobimetinib can be decreased when it is combined with Mitotane.
CocaineThe serum concentration of Cocaine can be decreased when it is combined with Mitotane.
CodeineThe serum concentration of Codeine can be decreased when it is combined with Mitotane.
ColchicineThe serum concentration of Colchicine can be decreased when it is combined with Mitotane.
ConivaptanThe serum concentration of Conivaptan can be decreased when it is combined with Mitotane.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be decreased when it is combined with Mitotane.
Cortisone acetateThe serum concentration of Cortisone acetate can be decreased when it is combined with Mitotane.
CrizotinibThe serum concentration of Crizotinib can be decreased when it is combined with Mitotane.
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be decreased when it is combined with Mitotane.
CyclophosphamideThe serum concentration of Cyclophosphamide can be decreased when it is combined with Mitotane.
CyclophosphamideCyclophosphamide may increase the cardiotoxic activities of Mitotane.
CyclosporineThe serum concentration of Cyclosporine can be decreased when it is combined with Mitotane.
CytarabineThe serum concentration of Cytarabine can be decreased when it is combined with Mitotane.
DabrafenibThe serum concentration of Dabrafenib can be decreased when it is combined with Mitotane.
DaclatasvirThe serum concentration of Daclatasvir can be decreased when it is combined with Mitotane.
DantroleneThe serum concentration of Dantrolene can be decreased when it is combined with Mitotane.
DapagliflozinThe serum concentration of Dapagliflozin can be decreased when it is combined with Mitotane.
DapsoneThe serum concentration of Dapsone can be decreased when it is combined with Mitotane.
DarifenacinThe serum concentration of Darifenacin can be decreased when it is combined with Mitotane.
DarunavirThe serum concentration of Darunavir can be decreased when it is combined with Mitotane.
DasabuvirThe serum concentration of Dasabuvir can be decreased when it is combined with Mitotane.
DasatinibThe serum concentration of Dasatinib can be decreased when it is combined with Mitotane.
DaunorubicinThe serum concentration of Daunorubicin can be decreased when it is combined with Mitotane.
DehydroepiandrosteroneThe serum concentration of Dehydroepiandrosterone can be decreased when it is combined with Mitotane.
dehydroepiandrosterone sulfateThe serum concentration of dehydroepiandrosterone sulfate can be decreased when it is combined with Mitotane.
DelavirdineThe serum concentration of Delavirdine can be decreased when it is combined with Mitotane.
DeslanosideDeslanoside may decrease the cardiotoxic activities of Mitotane.
DesoximetasoneThe serum concentration of Desoximetasone can be decreased when it is combined with Mitotane.
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be decreased when it is combined with Mitotane.
DesvenlafaxineThe serum concentration of Desvenlafaxine can be decreased when it is combined with Mitotane.
DexamethasoneThe serum concentration of Dexamethasone can be decreased when it is combined with Mitotane.
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be decreased when it is combined with Mitotane.
DextromethorphanThe serum concentration of Dextromethorphan can be decreased when it is combined with Mitotane.
DextropropoxypheneThe serum concentration of Dextropropoxyphene can be decreased when it is combined with Mitotane.
DiazepamThe serum concentration of Diazepam can be decreased when it is combined with Mitotane.
DiclofenacThe serum concentration of Diclofenac can be decreased when it is combined with Mitotane.
DienogestThe serum concentration of Dienogest can be decreased when it is combined with Mitotane.
DiflorasoneThe serum concentration of Diflorasone can be decreased when it is combined with Mitotane.
DifluocortoloneThe serum concentration of Difluocortolone can be decreased when it is combined with Mitotane.
DifluprednateThe serum concentration of Difluprednate can be decreased when it is combined with Mitotane.
DigitoxinThe serum concentration of Digitoxin can be decreased when it is combined with Mitotane.
DigitoxinDigitoxin may decrease the cardiotoxic activities of Mitotane.
DigoxinThe serum concentration of Digoxin can be decreased when it is combined with Mitotane.
DigoxinDigoxin may decrease the cardiotoxic activities of Mitotane.
DihydrocodeineThe serum concentration of Dihydrocodeine can be decreased when it is combined with Mitotane.
DihydroergotamineThe serum concentration of Dihydroergotamine can be decreased when it is combined with Mitotane.
DiltiazemThe serum concentration of Diltiazem can be decreased when it is combined with Mitotane.
DisopyramideThe serum concentration of Disopyramide can be decreased when it is combined with Mitotane.
DisulfiramThe serum concentration of Disulfiram can be decreased when it is combined with Mitotane.
DocetaxelThe serum concentration of Docetaxel can be decreased when it is combined with Mitotane.
DocetaxelThe risk or severity of adverse effects can be increased when Docetaxel is combined with Mitotane.
DofetilideThe serum concentration of Dofetilide can be decreased when it is combined with Mitotane.
DolasetronThe serum concentration of Dolasetron can be decreased when it is combined with Mitotane.
DomperidoneThe serum concentration of Domperidone can be decreased when it is combined with Mitotane.
DonepezilThe serum concentration of Donepezil can be decreased when it is combined with Mitotane.
DorzolamideThe serum concentration of Dorzolamide can be decreased when it is combined with Mitotane.
DoxepinThe serum concentration of Doxepin can be decreased when it is combined with Mitotane.
DoxorubicinThe serum concentration of Doxorubicin can be decreased when it is combined with Mitotane.
DronabinolThe serum concentration of Dronabinol can be decreased when it is combined with Mitotane.
DronedaroneThe serum concentration of Dronedarone can be decreased when it is combined with Mitotane.
DutasterideThe serum concentration of Dutasteride can be decreased when it is combined with Mitotane.
EfavirenzThe serum concentration of Efavirenz can be decreased when it is combined with Mitotane.
EletriptanThe serum concentration of Eletriptan can be decreased when it is combined with Mitotane.
EliglustatThe serum concentration of Eliglustat can be decreased when it is combined with Mitotane.
ElvitegravirThe serum concentration of Elvitegravir can be decreased when it is combined with Mitotane.
EnalaprilThe serum concentration of Enalapril can be decreased when it is combined with Mitotane.
EnzalutamideThe serum concentration of Enzalutamide can be decreased when it is combined with Mitotane.
EpinastineThe serum concentration of Epinastine can be decreased when it is combined with Mitotane.
EplerenoneThe serum concentration of Eplerenone can be decreased when it is combined with Mitotane.
EquileninThe serum concentration of Equilenin can be decreased when it is combined with Mitotane.
EquilinThe serum concentration of Equilin can be decreased when it is combined with Mitotane.
ErgocalciferolThe serum concentration of Ergocalciferol can be decreased when it is combined with Mitotane.
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be decreased when it is combined with Mitotane.
ErgonovineThe serum concentration of Ergonovine can be decreased when it is combined with Mitotane.
ErgotamineThe serum concentration of Ergotamine can be decreased when it is combined with Mitotane.
ErlotinibThe serum concentration of Erlotinib can be decreased when it is combined with Mitotane.
ErythromycinThe serum concentration of Erythromycin can be decreased when it is combined with Mitotane.
EscitalopramThe serum concentration of Escitalopram can be decreased when it is combined with Mitotane.
EsomeprazoleThe serum concentration of Esomeprazole can be decreased when it is combined with Mitotane.
EstazolamThe serum concentration of Estazolam can be decreased when it is combined with Mitotane.
EstradiolThe serum concentration of Estradiol can be decreased when it is combined with Mitotane.
Estradiol valerate/DienogestThe serum concentration of Estradiol valerate/Dienogest can be decreased when it is combined with Mitotane.
EstramustineThe serum concentration of Estramustine can be decreased when it is combined with Mitotane.
EstroneThe serum concentration of Estrone can be decreased when it is combined with Mitotane.
Estrone sulfateThe serum concentration of Estrone sulfate can be decreased when it is combined with Mitotane.
EszopicloneThe serum concentration of Eszopiclone can be decreased when it is combined with Mitotane.
EthanolThe serum concentration of Ethanol can be decreased when it is combined with Mitotane.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Mitotane.
EthosuximideThe serum concentration of Ethosuximide can be decreased when it is combined with Mitotane.
EthylmorphineThe serum concentration of Ethylmorphine can be decreased when it is combined with Mitotane.
EtonogestrelThe serum concentration of Etonogestrel can be decreased when it is combined with Mitotane.
EtoposideThe serum concentration of Etoposide can be decreased when it is combined with Mitotane.
EtoricoxibThe serum concentration of Etoricoxib can be decreased when it is combined with Mitotane.
EtravirineThe serum concentration of Etravirine can be decreased when it is combined with Mitotane.
EverolimusThe serum concentration of Everolimus can be decreased when it is combined with Mitotane.
ExemestaneThe serum concentration of Exemestane can be decreased when it is combined with Mitotane.
FamciclovirThe serum concentration of Famciclovir can be decreased when it is combined with Mitotane.
FelbamateThe serum concentration of Felbamate can be decreased when it is combined with Mitotane.
FelodipineThe serum concentration of Felodipine can be decreased when it is combined with Mitotane.
FenofibrateThe serum concentration of Fenofibrate can be decreased when it is combined with Mitotane.
FentanylThe serum concentration of Fentanyl can be decreased when it is combined with Mitotane.
FesoterodineThe serum concentration of Fesoterodine can be decreased when it is combined with Mitotane.
FinasterideThe serum concentration of Finasteride can be decreased when it is combined with Mitotane.
FingolimodThe serum concentration of Fingolimod can be decreased when it is combined with Mitotane.
FlibanserinThe serum concentration of Flibanserin can be decreased when it is combined with Mitotane.
FludrocortisoneThe serum concentration of Fludrocortisone can be decreased when it is combined with Mitotane.
FlumethasoneThe serum concentration of Flumethasone can be decreased when it is combined with Mitotane.
FlunisolideThe serum concentration of Flunisolide can be decreased when it is combined with Mitotane.
FlunitrazepamThe serum concentration of Flunitrazepam can be decreased when it is combined with Mitotane.
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be decreased when it is combined with Mitotane.
FluocinonideThe serum concentration of Fluocinonide can be decreased when it is combined with Mitotane.
FluocortoloneThe serum concentration of Fluocortolone can be decreased when it is combined with Mitotane.
FluorometholoneThe serum concentration of Fluorometholone can be decreased when it is combined with Mitotane.
FluoxetineThe serum concentration of Fluoxetine can be decreased when it is combined with Mitotane.
FluprednideneThe serum concentration of Fluprednidene can be decreased when it is combined with Mitotane.
FluprednisoloneThe serum concentration of Fluprednisolone can be decreased when it is combined with Mitotane.
FlurandrenolideThe serum concentration of Flurandrenolide can be decreased when it is combined with Mitotane.
FlurazepamThe serum concentration of Flurazepam can be decreased when it is combined with Mitotane.
FlutamideThe serum concentration of Flutamide can be decreased when it is combined with Mitotane.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be decreased when it is combined with Mitotane.
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be decreased when it is combined with Mitotane.
FluvastatinThe serum concentration of Fluvastatin can be decreased when it is combined with Mitotane.
FosamprenavirThe serum concentration of Fosamprenavir can be decreased when it is combined with Mitotane.
FulvestrantThe serum concentration of Fulvestrant can be decreased when it is combined with Mitotane.
GalantamineThe serum concentration of Galantamine can be decreased when it is combined with Mitotane.
GefitinibThe serum concentration of Gefitinib can be decreased when it is combined with Mitotane.
GemfibrozilThe serum concentration of Gemfibrozil can be decreased when it is combined with Mitotane.
GlipizideThe serum concentration of Glipizide can be decreased when it is combined with Mitotane.
GlyburideThe serum concentration of Glyburide can be decreased when it is combined with Mitotane.
GranisetronThe serum concentration of Granisetron can be decreased when it is combined with Mitotane.
GrepafloxacinThe serum concentration of Grepafloxacin can be decreased when it is combined with Mitotane.
GuanfacineThe serum concentration of Guanfacine can be decreased when it is combined with Mitotane.
HalofantrineThe serum concentration of Halofantrine can be decreased when it is combined with Mitotane.
HaloperidolThe serum concentration of Haloperidol can be decreased when it is combined with Mitotane.
HalothaneThe serum concentration of Halothane can be decreased when it is combined with Mitotane.
HexobarbitalThe serum concentration of Hexobarbital can be decreased when it is combined with Mitotane.
Histamine PhosphateThe serum concentration of Histamine Phosphate can be decreased when it is combined with Mitotane.
HydrocodoneThe serum concentration of Hydrocodone can be decreased when it is combined with Mitotane.
HydrocortisoneThe serum concentration of Hydrocortisone can be decreased when it is combined with Mitotane.
HydromorphoneThe serum concentration of Hydromorphone can be decreased when it is combined with Mitotane.
Hydroxyprogesterone caproateThe serum concentration of Hydroxyprogesterone caproate can be decreased when it is combined with Mitotane.
IbrutinibThe serum concentration of Ibrutinib can be decreased when it is combined with Mitotane.
IdelalisibThe serum concentration of Idelalisib can be decreased when it is combined with Mitotane.
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be increased when Ifosfamide is used in combination with Mitotane.
IloperidoneThe serum concentration of Iloperidone can be decreased when it is combined with Mitotane.
ImatinibThe serum concentration of Imatinib can be decreased when it is combined with Mitotane.
ImipramineThe serum concentration of Imipramine can be decreased when it is combined with Mitotane.
ImiquimodThe serum concentration of Imiquimod can be decreased when it is combined with Mitotane.
IndacaterolThe serum concentration of Indacaterol can be decreased when it is combined with Mitotane.
IndapamideThe serum concentration of Indapamide can be decreased when it is combined with Mitotane.
IndinavirThe serum concentration of Indinavir can be decreased when it is combined with Mitotane.
Ipratropium bromideThe serum concentration of Ipratropium bromide can be decreased when it is combined with Mitotane.
IrinotecanThe serum concentration of the active metabolites of Irinotecan can be reduced when Irinotecan is used in combination with Mitotane resulting in a loss in efficacy.
IsavuconazoniumThe serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Mitotane resulting in a loss in efficacy.
Isosorbide DinitrateThe serum concentration of Isosorbide Dinitrate can be decreased when it is combined with Mitotane.
Isosorbide MononitrateThe serum concentration of Isosorbide Mononitrate can be decreased when it is combined with Mitotane.
IsradipineThe serum concentration of Isradipine can be decreased when it is combined with Mitotane.
ItraconazoleThe serum concentration of Itraconazole can be decreased when it is combined with Mitotane.
IvabradineThe serum concentration of Ivabradine can be decreased when it is combined with Mitotane.
IvacaftorThe serum concentration of Ivacaftor can be decreased when it is combined with Mitotane.
IvermectinThe serum concentration of Ivermectin can be decreased when it is combined with Mitotane.
IxabepiloneThe serum concentration of Ixabepilone can be decreased when it is combined with Mitotane.
IxazomibThe serum concentration of Ixazomib can be decreased when it is combined with Mitotane.
KetamineThe serum concentration of Ketamine can be decreased when it is combined with Mitotane.
KetazolamThe serum concentration of Ketazolam can be decreased when it is combined with Mitotane.
KetobemidoneThe serum concentration of Ketobemidone can be decreased when it is combined with Mitotane.
KetoconazoleThe serum concentration of Ketoconazole can be decreased when it is combined with Mitotane.
LansoprazoleThe serum concentration of Lansoprazole can be decreased when it is combined with Mitotane.
LapatinibThe serum concentration of Lapatinib can be decreased when it is combined with Mitotane.
LaquinimodThe serum concentration of Laquinimod can be decreased when it is combined with Mitotane.
LenvatinibThe serum concentration of Lenvatinib can be decreased when it is combined with Mitotane.
LercanidipineThe serum concentration of Lercanidipine can be decreased when it is combined with Mitotane.
LetrozoleThe serum concentration of Letrozole can be decreased when it is combined with Mitotane.
LevobupivacaineThe serum concentration of Levobupivacaine can be decreased when it is combined with Mitotane.
LevocetirizineThe serum concentration of Levocetirizine can be decreased when it is combined with Mitotane.
Levomethadyl AcetateThe serum concentration of Levomethadyl Acetate can be decreased when it is combined with Mitotane.
LevomilnacipranThe serum concentration of Levomilnacipran can be decreased when it is combined with Mitotane.
LevonorgestrelThe serum concentration of Levonorgestrel can be decreased when it is combined with Mitotane.
LevothyroxineThe serum concentration of Levothyroxine can be decreased when it is combined with Mitotane.
LidocaineThe serum concentration of Lidocaine can be decreased when it is combined with Mitotane.
LinagliptinThe serum concentration of Linagliptin can be decreased when it is combined with Mitotane.
LisurideThe serum concentration of Lisuride can be decreased when it is combined with Mitotane.
LomitapideThe serum concentration of Lomitapide can be decreased when it is combined with Mitotane.
LoperamideThe serum concentration of Loperamide can be decreased when it is combined with Mitotane.
LopinavirThe serum concentration of Lopinavir can be decreased when it is combined with Mitotane.
LoratadineThe serum concentration of Loratadine can be decreased when it is combined with Mitotane.
LorcaserinThe serum concentration of Lorcaserin can be decreased when it is combined with Mitotane.
LosartanThe serum concentration of Losartan can be decreased when it is combined with Mitotane.
LovastatinThe serum concentration of Lovastatin can be decreased when it is combined with Mitotane.
LumefantrineThe serum concentration of Lumefantrine can be decreased when it is combined with Mitotane.
LurasidoneThe serum concentration of Lurasidone can be decreased when it is combined with Mitotane.
MacitentanThe serum concentration of Macitentan can be decreased when it is combined with Mitotane.
MaravirocThe serum concentration of Maraviroc can be decreased when it is combined with Mitotane.
MebendazoleThe serum concentration of Mebendazole can be decreased when it is combined with Mitotane.
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Mitotane.
MedrysoneThe serum concentration of Medrysone can be decreased when it is combined with Mitotane.
MefloquineThe serum concentration of Mefloquine can be decreased when it is combined with Mitotane.
MelengestrolThe serum concentration of Melengestrol can be decreased when it is combined with Mitotane.
MeloxicamThe serum concentration of Meloxicam can be decreased when it is combined with Mitotane.
MethadoneThe serum concentration of Methadone can be decreased when it is combined with Mitotane.
MethaqualoneThe serum concentration of Methaqualone can be decreased when it is combined with Mitotane.
MethoxsalenThe serum concentration of Methoxsalen can be decreased when it is combined with Mitotane.
MethoxyfluraneThe serum concentration of Methoxyflurane can be decreased when it is combined with Mitotane.
MethylprednisoloneThe serum concentration of Methylprednisolone can be decreased when it is combined with Mitotane.
MethyltestosteroneThe serum concentration of Methyltestosterone can be decreased when it is combined with Mitotane.
MetronidazoleThe serum concentration of Metronidazole can be decreased when it is combined with Mitotane.
MexiletineThe serum concentration of Mexiletine can be decreased when it is combined with Mitotane.
MianserinThe serum concentration of Mianserin can be decreased when it is combined with Mitotane.
MibefradilThe serum concentration of Mibefradil can be decreased when it is combined with Mitotane.
MiconazoleThe serum concentration of Miconazole can be decreased when it is combined with Mitotane.
MidazolamThe serum concentration of Midazolam can be decreased when it is combined with Mitotane.
MifepristoneThe serum concentration of Mifepristone can be decreased when it is combined with Mitotane.
MirabegronThe serum concentration of Mirabegron can be decreased when it is combined with Mitotane.
MirtazapineThe serum concentration of Mirtazapine can be decreased when it is combined with Mitotane.
ModafinilThe serum concentration of Modafinil can be decreased when it is combined with Mitotane.
MometasoneThe serum concentration of Mometasone can be decreased when it is combined with Mitotane.
MontelukastThe serum concentration of Montelukast can be decreased when it is combined with Mitotane.
MorphineThe serum concentration of Morphine can be decreased when it is combined with Mitotane.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be decreased when it is combined with Mitotane.
NaloxegolThe serum concentration of Naloxegol can be decreased when it is combined with Mitotane.
NaloxoneThe serum concentration of Naloxone can be decreased when it is combined with Mitotane.
NateglinideThe serum concentration of Nateglinide can be decreased when it is combined with Mitotane.
NefazodoneThe serum concentration of Nefazodone can be decreased when it is combined with Mitotane.
NelfinavirThe serum concentration of Nelfinavir can be decreased when it is combined with Mitotane.
NetupitantThe serum concentration of Netupitant can be decreased when it is combined with Mitotane.
NevirapineThe serum concentration of Nevirapine can be decreased when it is combined with Mitotane.
NicardipineThe serum concentration of Nicardipine can be decreased when it is combined with Mitotane.
NicotineThe serum concentration of Nicotine can be decreased when it is combined with Mitotane.
NifedipineThe serum concentration of Nifedipine can be decreased when it is combined with Mitotane.
NilotinibThe serum concentration of Nilotinib can be decreased when it is combined with Mitotane.
NilvadipineThe serum concentration of Nilvadipine can be decreased when it is combined with Mitotane.
NimodipineThe serum concentration of Nimodipine can be decreased when it is combined with Mitotane.
NisoldipineThe serum concentration of Nisoldipine can be decreased when it is combined with Mitotane.
NitrazepamThe serum concentration of Nitrazepam can be decreased when it is combined with Mitotane.
NitrendipineThe serum concentration of Nitrendipine can be decreased when it is combined with Mitotane.
NorethisteroneThe serum concentration of Norethisterone can be decreased when it is combined with Mitotane.
NorgestrelThe serum concentration of Norgestrel can be decreased when it is combined with Mitotane.
NortriptylineThe serum concentration of Nortriptyline can be decreased when it is combined with Mitotane.
OlaparibThe serum concentration of Olaparib can be decreased when it is combined with Mitotane.
OlopatadineThe serum concentration of Olopatadine can be decreased when it is combined with Mitotane.
OmeprazoleThe serum concentration of Omeprazole can be decreased when it is combined with Mitotane.
OndansetronThe serum concentration of Ondansetron can be decreased when it is combined with Mitotane.
OrphenadrineThe serum concentration of Orphenadrine can be decreased when it is combined with Mitotane.
OsimertinibThe serum concentration of Osimertinib can be decreased when it is combined with Mitotane.
OspemifeneThe serum concentration of Ospemifene can be decreased when it is combined with Mitotane.
OuabainOuabain may decrease the cardiotoxic activities of Mitotane.
OxazepamThe serum concentration of Oxazepam can be decreased when it is combined with Mitotane.
OxybutyninThe serum concentration of Oxybutynin can be decreased when it is combined with Mitotane.
OxycodoneThe serum concentration of Oxycodone can be decreased when it is combined with Mitotane.
OxymorphoneThe serum concentration of Oxymorphone can be decreased when it is combined with Mitotane.
PaclitaxelThe serum concentration of Paclitaxel can be decreased when it is combined with Mitotane.
PaclitaxelThe risk or severity of adverse effects can be increased when Paclitaxel is combined with Mitotane.
PalbociclibThe serum concentration of Palbociclib can be decreased when it is combined with Mitotane.
PalonosetronThe serum concentration of Palonosetron can be decreased when it is combined with Mitotane.
PanobinostatThe serum concentration of Panobinostat can be decreased when it is combined with Mitotane.
PantoprazoleThe serum concentration of Pantoprazole can be decreased when it is combined with Mitotane.
ParamethadioneThe serum concentration of Paramethadione can be decreased when it is combined with Mitotane.
ParamethasoneThe serum concentration of Paramethasone can be decreased when it is combined with Mitotane.
ParecoxibThe serum concentration of Parecoxib can be decreased when it is combined with Mitotane.
ParicalcitolThe serum concentration of Paricalcitol can be decreased when it is combined with Mitotane.
ParitaprevirThe serum concentration of Paritaprevir can be decreased when it is combined with Mitotane.
PazopanibThe serum concentration of Pazopanib can be decreased when it is combined with Mitotane.
PentamidineThe serum concentration of Pentamidine can be decreased when it is combined with Mitotane.
PerampanelThe serum concentration of Perampanel can be decreased when it is combined with Mitotane.
PergolideThe serum concentration of Pergolide can be decreased when it is combined with Mitotane.
PerhexilineThe serum concentration of Perhexiline can be decreased when it is combined with Mitotane.
PermethrinThe serum concentration of Permethrin can be decreased when it is combined with Mitotane.
PerphenazineThe serum concentration of Perphenazine can be decreased when it is combined with Mitotane.
PethidineThe serum concentration of Pethidine can be decreased when it is combined with Mitotane.
PhenacetinThe serum concentration of Phenacetin can be decreased when it is combined with Mitotane.
PhenoxybenzamineThe serum concentration of Phenoxybenzamine can be decreased when it is combined with Mitotane.
PhenprocoumonThe serum concentration of Phenprocoumon can be decreased when it is combined with Mitotane.
PhenytoinThe serum concentration of Phenytoin can be decreased when it is combined with Mitotane.
PilocarpineThe serum concentration of Pilocarpine can be decreased when it is combined with Mitotane.
PimecrolimusThe serum concentration of Pimecrolimus can be decreased when it is combined with Mitotane.
PimozideThe serum concentration of Pimozide can be decreased when it is combined with Mitotane.
PinacidilThe serum concentration of Pinacidil can be decreased when it is combined with Mitotane.
PioglitazoneThe serum concentration of Pioglitazone can be decreased when it is combined with Mitotane.
PipotiazineThe serum concentration of Pipotiazine can be decreased when it is combined with Mitotane.
PodofiloxThe serum concentration of Podofilox can be decreased when it is combined with Mitotane.
PomalidomideThe serum concentration of Pomalidomide can be decreased when it is combined with Mitotane.
PonatinibThe serum concentration of Ponatinib can be decreased when it is combined with Mitotane.
PosaconazoleThe serum concentration of Posaconazole can be decreased when it is combined with Mitotane.
PrasugrelThe serum concentration of Prasugrel can be decreased when it is combined with Mitotane.
PravastatinThe serum concentration of Pravastatin can be decreased when it is combined with Mitotane.
PrazepamThe serum concentration of Prazepam can be decreased when it is combined with Mitotane.
PraziquantelThe serum concentration of Praziquantel can be decreased when it is combined with Mitotane.
PrednicarbateThe serum concentration of Prednicarbate can be decreased when it is combined with Mitotane.
PrednisoloneThe serum concentration of Prednisolone can be decreased when it is combined with Mitotane.
PrednisoneThe serum concentration of Prednisone can be decreased when it is combined with Mitotane.
PregnenoloneThe serum concentration of Pregnenolone can be decreased when it is combined with Mitotane.
PrimaquineThe serum concentration of Primaquine can be decreased when it is combined with Mitotane.
ProchlorperazineThe serum concentration of Prochlorperazine can be decreased when it is combined with Mitotane.
ProgesteroneThe serum concentration of Progesterone can be decreased when it is combined with Mitotane.
ProguanilThe serum concentration of Proguanil can be decreased when it is combined with Mitotane.
PromazineThe serum concentration of Promazine can be decreased when it is combined with Mitotane.
PropafenoneThe serum concentration of Propafenone can be decreased when it is combined with Mitotane.
PropofolThe serum concentration of Propofol can be decreased when it is combined with Mitotane.
PropranololThe serum concentration of Propranolol can be decreased when it is combined with Mitotane.
PyrazinamideThe serum concentration of Pyrazinamide can be decreased when it is combined with Mitotane.
QuazepamThe serum concentration of Quazepam can be decreased when it is combined with Mitotane.
QuetiapineThe serum concentration of Quetiapine can be decreased when it is combined with Mitotane.
QuinacrineThe serum concentration of Quinacrine can be decreased when it is combined with Mitotane.
QuinidineThe serum concentration of Quinidine can be decreased when it is combined with Mitotane.
QuinineThe serum concentration of Quinine can be decreased when it is combined with Mitotane.
RabeprazoleThe serum concentration of Rabeprazole can be decreased when it is combined with Mitotane.
RaloxifeneThe serum concentration of Raloxifene can be decreased when it is combined with Mitotane.
RamelteonThe serum concentration of Ramelteon can be decreased when it is combined with Mitotane.
RanolazineThe serum concentration of Ranolazine can be decreased when it is combined with Mitotane.
ReboxetineThe serum concentration of Reboxetine can be decreased when it is combined with Mitotane.
RegorafenibThe serum concentration of Regorafenib can be decreased when it is combined with Mitotane.
RepaglinideThe serum concentration of Repaglinide can be decreased when it is combined with Mitotane.
RetapamulinThe serum concentration of Retapamulin can be decreased when it is combined with Mitotane.
RifabutinThe serum concentration of Rifabutin can be decreased when it is combined with Mitotane.
RifampicinThe serum concentration of Rifampicin can be decreased when it is combined with Mitotane.
RilpivirineThe serum concentration of Rilpivirine can be decreased when it is combined with Mitotane.
RimexoloneThe serum concentration of Rimexolone can be decreased when it is combined with Mitotane.
RimonabantThe serum concentration of Rimonabant can be decreased when it is combined with Mitotane.
RiociguatThe serum concentration of Riociguat can be decreased when it is combined with Mitotane.
RisperidoneThe serum concentration of Risperidone can be decreased when it is combined with Mitotane.
RitonavirThe serum concentration of Ritonavir can be decreased when it is combined with Mitotane.
RivaroxabanThe serum concentration of Rivaroxaban can be decreased when it is combined with Mitotane.
RofecoxibThe serum concentration of Rofecoxib can be decreased when it is combined with Mitotane.
RoflumilastThe serum concentration of Roflumilast can be decreased when it is combined with Mitotane.
RolapitantThe serum concentration of Rolapitant can be decreased when it is combined with Mitotane.
RomidepsinThe serum concentration of Romidepsin can be decreased when it is combined with Mitotane.
RopiniroleThe serum concentration of Ropinirole can be decreased when it is combined with Mitotane.
RopivacaineThe serum concentration of Ropivacaine can be decreased when it is combined with Mitotane.
RosuvastatinThe serum concentration of Rosuvastatin can be decreased when it is combined with Mitotane.
RotigotineThe serum concentration of Rotigotine can be decreased when it is combined with Mitotane.
RoxithromycinThe serum concentration of Roxithromycin can be decreased when it is combined with Mitotane.
RuxolitinibThe serum concentration of Ruxolitinib can be decreased when it is combined with Mitotane.
SalmeterolThe serum concentration of Salmeterol can be decreased when it is combined with Mitotane.
SaquinavirThe serum concentration of Saquinavir can be decreased when it is combined with Mitotane.
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Mitotane.
SelegilineThe serum concentration of Selegiline can be decreased when it is combined with Mitotane.
SelexipagThe serum concentration of Selexipag can be decreased when it is combined with Mitotane.
SeratrodastThe serum concentration of Seratrodast can be decreased when it is combined with Mitotane.
SertindoleThe serum concentration of Sertindole can be decreased when it is combined with Mitotane.
SertralineThe serum concentration of Sertraline can be decreased when it is combined with Mitotane.
SevofluraneThe serum concentration of Sevoflurane can be decreased when it is combined with Mitotane.
SibutramineThe serum concentration of Sibutramine can be decreased when it is combined with Mitotane.
SildenafilThe serum concentration of Sildenafil can be decreased when it is combined with Mitotane.
SilodosinThe serum concentration of Silodosin can be decreased when it is combined with Mitotane.
SimeprevirThe serum concentration of Simeprevir can be decreased when it is combined with Mitotane.
SimvastatinThe serum concentration of Simvastatin can be decreased when it is combined with Mitotane.
SirolimusThe serum concentration of Sirolimus can be decreased when it is combined with Mitotane.
SitagliptinThe serum concentration of Sitagliptin can be decreased when it is combined with Mitotane.
SolifenacinThe serum concentration of Solifenacin can be decreased when it is combined with Mitotane.
SonidegibThe serum concentration of Sonidegib can be decreased when it is combined with Mitotane.
SorafenibThe serum concentration of Sorafenib can be decreased when it is combined with Mitotane.
SpiramycinThe serum concentration of Spiramycin can be decreased when it is combined with Mitotane.
SpironolactoneThe therapeutic efficacy of Mitotane can be decreased when used in combination with Spironolactone.
SufentanilThe serum concentration of Sufentanil can be decreased when it is combined with Mitotane.
SulfadiazineThe serum concentration of Sulfadiazine can be decreased when it is combined with Mitotane.
SulfamethoxazoleThe serum concentration of Sulfamethoxazole can be decreased when it is combined with Mitotane.
SulfinpyrazoneThe serum concentration of Sulfinpyrazone can be decreased when it is combined with Mitotane.
SunitinibThe serum concentration of Sunitinib can be decreased when it is combined with Mitotane.
SuvorexantThe serum concentration of Suvorexant can be decreased when it is combined with Mitotane.
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be decreased when it is combined with Mitotane.
Synthetic Conjugated Estrogens, BThe serum concentration of Synthetic Conjugated Estrogens, B can be decreased when it is combined with Mitotane.
TacrolimusThe serum concentration of Tacrolimus can be decreased when it is combined with Mitotane.
TadalafilThe serum concentration of Tadalafil can be decreased when it is combined with Mitotane.
TamoxifenThe serum concentration of Tamoxifen can be decreased when it is combined with Mitotane.
TamsulosinThe serum concentration of Tamsulosin can be decreased when it is combined with Mitotane.
TasimelteonThe serum concentration of Tasimelteon can be decreased when it is combined with Mitotane.
TasosartanThe serum concentration of Tasosartan can be decreased when it is combined with Mitotane.
Taurochenodeoxycholic acidThe serum concentration of Taurochenodeoxycholic acid can be decreased when it is combined with Mitotane.
TelaprevirThe serum concentration of Telaprevir can be decreased when it is combined with Mitotane.
TelithromycinThe serum concentration of Telithromycin can be decreased when it is combined with Mitotane.
TemazepamThe serum concentration of Temazepam can be decreased when it is combined with Mitotane.
TemsirolimusThe serum concentration of Temsirolimus can be decreased when it is combined with Mitotane.
TeniposideThe serum concentration of Teniposide can be decreased when it is combined with Mitotane.
TerbinafineThe serum concentration of Terbinafine can be decreased when it is combined with Mitotane.
TerfenadineThe serum concentration of Terfenadine can be decreased when it is combined with Mitotane.
TesmilifeneThe serum concentration of Tesmilifene can be decreased when it is combined with Mitotane.
TestosteroneThe serum concentration of Testosterone can be decreased when it is combined with Mitotane.
TetracyclineThe serum concentration of Tetracycline can be decreased when it is combined with Mitotane.
TheophyllineThe serum concentration of Theophylline can be decreased when it is combined with Mitotane.
ThiotepaThe serum concentration of Thiotepa can be decreased when it is combined with Mitotane.
TiagabineThe serum concentration of Tiagabine can be decreased when it is combined with Mitotane.
TicagrelorThe serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Mitotane resulting in a loss in efficacy.
TiclopidineThe serum concentration of Ticlopidine can be decreased when it is combined with Mitotane.
TinidazoleThe serum concentration of Tinidazole can be decreased when it is combined with Mitotane.
TiotropiumThe serum concentration of Tiotropium can be decreased when it is combined with Mitotane.
TipranavirThe serum concentration of Tipranavir can be decreased when it is combined with Mitotane.
TixocortolThe serum concentration of Tixocortol can be decreased when it is combined with Mitotane.
TofacitinibThe serum concentration of Tofacitinib can be decreased when it is combined with Mitotane.
TolterodineThe serum concentration of Tolterodine can be decreased when it is combined with Mitotane.
TolvaptanThe serum concentration of Tolvaptan can be decreased when it is combined with Mitotane.
ToremifeneThe serum concentration of Toremifene can be decreased when it is combined with Mitotane.
TrabectedinThe serum concentration of Trabectedin can be decreased when it is combined with Mitotane.
TramadolThe serum concentration of Tramadol can be decreased when it is combined with Mitotane.
TrastuzumabTrastuzumab may increase the cardiotoxic activities of Mitotane.
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be decreased when it is combined with Mitotane.
TrazodoneThe serum concentration of Trazodone can be decreased when it is combined with Mitotane.
TretinoinThe serum concentration of Tretinoin can be decreased when it is combined with Mitotane.
TriamcinoloneThe serum concentration of Triamcinolone can be decreased when it is combined with Mitotane.
TriazolamThe serum concentration of Triazolam can be decreased when it is combined with Mitotane.
TrimethadioneThe serum concentration of Trimethadione can be decreased when it is combined with Mitotane.
TrimethoprimThe serum concentration of Trimethoprim can be decreased when it is combined with Mitotane.
TrimipramineThe serum concentration of Trimipramine can be decreased when it is combined with Mitotane.
TroglitazoneThe serum concentration of Troglitazone can be decreased when it is combined with Mitotane.
TroleandomycinThe serum concentration of Troleandomycin can be decreased when it is combined with Mitotane.
UdenafilThe serum concentration of Udenafil can be decreased when it is combined with Mitotane.
UlipristalThe serum concentration of Ulipristal can be decreased when it is combined with Mitotane.
ValdecoxibThe serum concentration of Valdecoxib can be decreased when it is combined with Mitotane.
VandetanibThe serum concentration of Vandetanib can be decreased when it is combined with Mitotane.
VanoxerineThe serum concentration of Vanoxerine can be decreased when it is combined with Mitotane.
VardenafilThe serum concentration of Vardenafil can be decreased when it is combined with Mitotane.
VemurafenibThe serum concentration of Vemurafenib can be decreased when it is combined with Mitotane.
VenlafaxineThe serum concentration of Venlafaxine can be decreased when it is combined with Mitotane.
VerapamilThe serum concentration of Verapamil can be decreased when it is combined with Mitotane.
VicrivirocThe serum concentration of Vicriviroc can be decreased when it is combined with Mitotane.
VilanterolThe serum concentration of Vilanterol can be decreased when it is combined with Mitotane.
VilazodoneThe serum concentration of Vilazodone can be decreased when it is combined with Mitotane.
VinblastineThe serum concentration of Vinblastine can be decreased when it is combined with Mitotane.
VincristineThe serum concentration of Vincristine can be decreased when it is combined with Mitotane.
VindesineThe serum concentration of Vindesine can be decreased when it is combined with Mitotane.
VinorelbineThe serum concentration of Vinorelbine can be decreased when it is combined with Mitotane.
VismodegibThe serum concentration of Vismodegib can be decreased when it is combined with Mitotane.
VorapaxarThe serum concentration of Vorapaxar can be decreased when it is combined with Mitotane.
VoriconazoleThe serum concentration of Voriconazole can be decreased when it is combined with Mitotane.
VortioxetineThe serum concentration of Vortioxetine can be decreased when it is combined with Mitotane.
WarfarinThe serum concentration of Warfarin can be decreased when it is combined with Mitotane.
YohimbineThe serum concentration of Yohimbine can be decreased when it is combined with Mitotane.
ZafirlukastThe serum concentration of Zafirlukast can be decreased when it is combined with Mitotane.
ZalcitabineThe serum concentration of Zalcitabine can be decreased when it is combined with Mitotane.
ZaleplonThe serum concentration of Zaleplon can be decreased when it is combined with Mitotane.
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Mitotane.
ZileutonThe serum concentration of Zileuton can be decreased when it is combined with Mitotane.
ZiprasidoneThe serum concentration of Ziprasidone can be decreased when it is combined with Mitotane.
ZolpidemThe serum concentration of Zolpidem can be decreased when it is combined with Mitotane.
ZomepiracThe serum concentration of Zomepirac can be decreased when it is combined with Mitotane.
ZonisamideThe serum concentration of Zonisamide can be decreased when it is combined with Mitotane.
ZopicloneThe serum concentration of Zopiclone can be decreased when it is combined with Mitotane.
ZuclopenthixolThe serum concentration of Zuclopenthixol can be decreased when it is combined with Mitotane.
Food Interactions
  • Take without regard to meals.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inducer
General Function:
Steroid 11-beta-monooxygenase activity
Specific Function:
Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.
Gene Name:
CYP11B1
Uniprot ID:
P15538
Molecular Weight:
57572.44 Da
References
  1. Lindhe O, Skogseid B, Brandt I: Cytochrome P450-catalyzed binding of 3-methylsulfonyl-DDE and o,p'-DDD in human adrenal zona fasciculata/reticularis. J Clin Endocrinol Metab. 2002 Mar;87(3):1319-26. [PubMed:11889204 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
unknown
General Function:
Iron ion binding
Specific Function:
Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage.
Gene Name:
FDX1
Uniprot ID:
P10109
Molecular Weight:
19392.475 Da
References
  1. Kandul SV, Iatsyk MI, Kononenko VIa: [Comparative study of the effect of chloditan on the concentration of cytochrome P-450 and adrenodoxin in various organs of the dog and rat]. Fiziol Zh. 1986 Sep-Oct;32(5):579-84. [PubMed:3770229 ]
  2. Cabrini DA, Campos MM, Tratsk KS, Merino VF, Silva JA Jr, Souza GE, Avellar MC, Pesquero JB, Calixto JB: Molecular and pharmacological evidence for modulation of kinin B(1) receptor expression by endogenous glucocorticoids hormones in rats. Br J Pharmacol. 2001 Jan;132(2):567-77. [PubMed:11159707 ]
  3. Cai W, Counsell RE, Schteingart DE, Sinsheimer JE, Vaz AD, Wotring LL: Adrenal proteins bound by a reactive intermediate of mitotane. Cancer Chemother Pharmacol. 1997;39(6):537-40. [PubMed:9118466 ]

Carriers

Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Androgen binding
Specific Function:
Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.
Gene Name:
SHBG
Uniprot ID:
P04278
Molecular Weight:
43778.755 Da
References
  1. Nader N, Raverot G, Emptoz-Bonneton A, Dechaud H, Bonnay M, Baudin E, Pugeat M: Mitotane has an estrogenic effect on sex hormone-binding globulin and corticosteroid-binding globulin in humans. J Clin Endocrinol Metab. 2006 Jun;91(6):2165-70. Epub 2006 Mar 21. [PubMed:16551731 ]
  2. van Seters AP, Moolenaar AJ: Mitotane increases the blood levels of hormone-binding proteins. Acta Endocrinol (Copenh). 1991 May;124(5):526-33. [PubMed:1903011 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Steroid binding
Specific Function:
Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
Gene Name:
SERPINA6
Uniprot ID:
P08185
Molecular Weight:
45140.49 Da
References
  1. Nader N, Raverot G, Emptoz-Bonneton A, Dechaud H, Bonnay M, Baudin E, Pugeat M: Mitotane has an estrogenic effect on sex hormone-binding globulin and corticosteroid-binding globulin in humans. J Clin Endocrinol Metab. 2006 Jun;91(6):2165-70. Epub 2006 Mar 21. [PubMed:16551731 ]
  2. Tron'ko MD: [Effect of chlodithane (o,p'-DDD) on transcortin binding ability in Itsenko-Cushing's disease]. Fiziol Zh. 1970 Nov-Dec;16(6):844-5. [PubMed:5520073 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23