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Identification
NameLosartan
Accession NumberDB00678  (APRD00052)
TypeSmall Molecule
GroupsApproved
Description

Losartan is an angiotensin-receptor blocker (ARB) that may be used alone or with other agents to treat hypertension. Losartan and its longer acting metabolite, E-3174, lower blood pressure by antagonizing the renin-angiotensin-aldosterone system (RAAS); they compete with angiotensin II for binding to the type-1 angiotensin II receptor (AT1) subtype and prevents the blood pressure increasing effects of angiotensin II. Unlike angiotensin-converting enzyme (ACE) inhibitors, ARBs do not have the adverse effect of dry cough. Losartan may be used to treat hypertension, isolated systolic hypertension, left ventricular hypertrophy and diabetic nephropathy. It may also be used as an alternative agent for the treatment of systolic dysfunction, myocardial infarction, coronary artery disease, and heart failure.

Structure
Thumb
Synonyms
(2-Butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol
2-N-Butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole
DuP 89
Losartan
External Identifiers
  • MK594
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Act Losartantablet100 mgoralActavis Pharma Company2012-01-25Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Act Losartantablet50 mgoralActavis Pharma Company2012-01-25Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Act Losartantablet25 mgoralActavis Pharma Company2012-01-25Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ag-losartantablet50 mgoralAngita Pharma Inc.Not applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ag-losartantablet25 mgoralAngita Pharma Inc.Not applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ag-losartantablet100 mgoralAngita Pharma Inc.Not applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Auro-losartantablet100.0 mgoralAuro Pharma Inc2013-03-26Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Auro-losartantablet50.0 mgoralAuro Pharma Inc2013-03-26Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Auro-losartantablet25.0 mgoralAuro Pharma Inc2013-03-26Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Bio-losartantablet100 mgoralBiomed PharmaNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Bio-losartantablet50 mgoralBiomed PharmaNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Bio-losartantablet25 mgoralBiomed PharmaNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Cozaartablet25 mgoralMerck Canada Inc1995-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Cozaartablet, film coated25 mg/1oralMerck Sharp & Dohme Corp.1995-04-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cozaartablet, film coated100 mg/1oralREMEDYREPACK INC.2011-04-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cozaartablet, film coated100 mg/1oralPd Rx Pharmaceuticals, Inc.1995-04-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cozaartablet25 mg/1oralREMEDYREPACK INC.2011-04-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cozaartablet, film coated50 mg/1oralCardinal Health1995-04-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cozaartablet, film coated25 mg/1oralCardinal Health1995-04-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cozaartablet, film coated25 mg/1oralPhysicians Total Care, Inc.2004-06-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cozaartablet, film coated50 mg/1oralPhysicians Total Care, Inc.1996-04-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cozaartablet100 mgoralMerck Canada Inc1998-01-16Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Cozaartablet, film coated100 mg/1oralMerck Sharp & Dohme Corp.1995-04-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cozaartablet, film coated100 mg/1oralPhysicians Total Care, Inc.2003-08-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cozaartablet, film coated100 mg/1oralbryant ranch prepack1995-04-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cozaartablet50 mgoralMerck Canada Inc1995-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Cozaartablet, film coated50 mg/1oralMerck Sharp & Dohme Corp.1995-04-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cozaartablet, film coated25 mg/1oralREMEDYREPACK INC.2011-05-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cozaartablet, film coated50 mg/1oralbryant ranch prepack1995-04-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Ipg-losartantablet25 mgoralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ipg-losartantablet100 mgoralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ipg-losartantablet50 mgoralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Jamp-losartantablet25.0 mgoralJamp Pharma Corporation2013-06-11Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Jamp-losartantablet100.0 mgoralJamp Pharma Corporation2013-06-11Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Jamp-losartantablet50.0 mgoralJamp Pharma Corporation2013-06-11Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Losartantablet100 mgoralSanis Health Inc2012-07-20Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Losartantablet100 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Losartantablet50 mgoralSanis Health Inc2012-07-20Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Losartantablet100 mgoralActavis Pharma CompanyNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Losartantablet50 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Losartantablet25 mgoralSanis Health Inc2012-07-20Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Losartantablet50 mgoralActavis Pharma CompanyNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Losartantablet100 mgoralPro Doc Limitee2012-11-22Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Losartantablet25 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Losartantablet25 mgoralActavis Pharma CompanyNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Losartantablet100.0 mgoralSivem Pharmaceuticals Ulc2012-07-05Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Losartantablet100 mgoralFrosst A Division Of Merck Canada IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Losartantablet50 mgoralPro Doc Limitee2012-11-22Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Losartantablet50.0 mgoralSivem Pharmaceuticals Ulc2012-07-05Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Losartantablet50 mgoralFrosst A Division Of Merck Canada IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Losartantablet25 mgoralPro Doc Limitee2012-11-22Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Losartantablet25.0 mgoralSivem Pharmaceuticals Ulc2012-07-05Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Losartantablet25 mgoralFrosst A Division Of Merck Canada IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Losartan Potassiumtablet, film coated100 mg/1oralSandoz Inc.1995-04-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated50 mg/1oralSandoz Inc.1995-04-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated25 mg/1oralSandoz Inc.1995-04-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Mar-losartantablet25 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mar-losartantablet100 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mar-losartantablet50 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mint-losartantablet50.0 mgoralMint Pharmaceuticals Inc2014-01-16Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mint-losartantablet25.0 mgoralMint Pharmaceuticals Inc2014-01-16Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mint-losartantablet100.0 mgoralMint Pharmaceuticals Inc2014-01-16Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mylan-losartantablet25 mgoralMylan Pharmaceuticals Ulc2012-01-25Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mylan-losartantablet100 mgoralMylan Pharmaceuticals Ulc2012-01-25Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mylan-losartantablet50 mgoralMylan Pharmaceuticals Ulc2012-01-25Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-losartantablet100 mgoralPharmascience Inc2012-01-25Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-losartantablet50 mgoralPharmascience Inc2012-01-25Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-losartantablet25 mgoralPharmascience Inc2012-01-25Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Priva-losartantablet100 mgoralPharmapar IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Priva-losartantablet50 mgoralPharmapar IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Priva-losartantablet25 mgoralPharmapar IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ran-losartantablet50 mgoralRanbaxy Pharmaceuticals Canada Inc.2013-06-11Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ran-losartantablet25 mgoralRanbaxy Pharmaceuticals Canada Inc.2013-06-11Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ran-losartantablet100 mgoralRanbaxy Pharmaceuticals Canada Inc.2013-06-11Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sandoz Losartantablet50 mgoralSandoz Canada Incorporated2012-01-25Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sandoz Losartantablet25 mgoralSandoz Canada Incorporated2012-01-25Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sandoz Losartantablet100 mgoralSandoz Canada Incorporated2012-01-25Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Septa-losartantablet100 mgoralSepta Pharmaceuticals Inc2014-07-03Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Septa-losartantablet50 mgoralSepta Pharmaceuticals Inc2014-07-03Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Septa-losartantablet25 mgoralSepta Pharmaceuticals Inc2014-07-03Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Teva-losartantablet25 mgoralTeva Canada Limited2012-02-28Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Teva-losartantablet100 mgoralTeva Canada Limited2012-01-25Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Teva-losartantablet50 mgoralTeva Canada Limited2012-01-25Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Van-losartantablet100 mgoralVanc Pharmaceuticals Inc2015-06-08Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Van-losartantablet50 mgoralVanc Pharmaceuticals Inc2015-06-08Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Van-losartantablet25 mgoralVanc Pharmaceuticals Inc2015-06-08Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-losartantablet25 mgoralApotex Inc2012-04-13Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Apo-losartantablet100 mgoralApotex Inc2012-01-25Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Apo-losartantablet50 mgoralApotex Inc2012-01-25Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Losartantablet, film coated100 mg/1oralVirtus Pharmaceuticals2015-07-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartantablet, film coated50 mg/1oralVirtus Pharmaceuticals2015-07-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartantablet, film coated25 mg/1oralVirtus Pharmaceuticals2015-07-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated100 mg/1oralMicro Labs Limited2012-12-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated25 mg/1oralVirtus Pharmaceuticals LLC2014-03-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated25 mg/1oralDispensing Solutions, Inc.2010-12-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated50 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-04-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet25 mg/1oralRoxane Laboratories, Inc.2010-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet100 mg/1oralUnichem Pharmaceuticals (USA), Inc.2016-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated100 mg/1oralApotex Corp2010-10-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet50 mg/1oralUnit Dose Services2010-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet50 mg/1oralLegacy Pharmaceutical Packaging2011-02-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated25 mg/1oralSandoz Inc2010-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet50 mg/1oralLupin Pharmaceuticals, Inc.2010-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet50 mg/1oralTorrent Pharmaceuticals Limited2010-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated100 mg/1oralReady Meds2012-01-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated25 mg/1oralMylan Pharmaceuticals Inc.2012-12-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated25 mg/1oralMacleods Pharmaceuticals Limited2012-05-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet100 mg/1oralREMEDYREPACK INC.2015-03-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated100 mg/1oralClinical Solutions Wholesale2010-04-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated50 mg/1oralPreferred Pharmaceuticals, Inc.2011-03-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated100 mg/1oralSolco Healthcare US, LLC2014-07-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated50 mg/1oralMed Vantx, Inc.2010-10-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated50 mg/1oralQualitest Pharmaceuticals2012-01-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet25 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated25 mg/1oralProficient Rx LP2012-01-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated50 mg/1oralPhysicians Total Care, Inc.2010-04-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated100 mg/1oralGolden State Medical Supply, Inc.2011-02-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet50 mg/1oralAv Pak2014-03-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet25 mg/1oralLupin Pharmaceuticals, Inc.2010-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet100 mg/1oralTorrent Pharmaceuticals Limited2010-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated50 mg/1oralReady Meds2012-01-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated25 mg/1oralKAISER FOUNDATION HOSPITALS2015-12-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated100 mg/1oralEndo Pharmaceuticals Inc. DBA Endo Generic Products2010-11-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet50 mg/1oralREMEDYREPACK INC.2013-05-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet25 mg/1oralClinical Solutions Wholesale2010-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet50 mg/1oralPreferred Pharmaceuticals, Inc.2013-06-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated50 mg/1oralSolco Healthcare US, LLC2014-07-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated100 mg/1oralAurobindo Pharma Limited2010-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated25 mg/1oralQualitest Pharmaceuticals2012-01-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet50 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated50 mg/1oralGolden State Medical Supply, Inc.2011-02-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet25 mg/1oralAv Pak2014-03-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated50 mg/1oralCarilion Materials Management2010-04-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet25 mg/1oralTorrent Pharmaceuticals Limited2010-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated100 mg/1oralMc Kesson Packaging Services2010-10-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated100 mg/1oralTeva Pharmaceuticals USA Inc2010-04-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated50 mg/1oralEndo Pharmaceuticals Inc. DBA Endo Generic Products2010-11-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet100 mg/1oralREMEDYREPACK INC.2013-05-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet50 mg/1oralClinical Solutions Wholesale2010-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet50 mg/1oralLegacy Pharmaceutical Packaging, Llc2010-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated25 mg/1oralSolco Healthcare US, LLC2011-06-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated50 mg/1oralAurobindo Pharma Limited2010-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated100 mg/1oralWatson Laboratories, Inc.2011-02-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet100 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet50 mg/1oralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated25 mg/1oralGolden State Medical Supply, Inc.2011-02-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet50 mg/1oralREMEDYREPACK INC.2013-03-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated100 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2010-10-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated50 mg/1oralTeva Pharmaceuticals USA Inc2010-04-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated25 mg/1oralEndo Pharmaceuticals Inc. DBA Endo Generic Products2010-11-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet100 mg/1oralClinical Solutions Wholesale2010-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated50 mg/1oralLegacy Pharmaceutical Packaging2010-10-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated100 mg/1oralPd Rx Pharmaceuticals, Inc.2010-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet25 mg/1oralCarilion Materials Management2010-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet25 mg/1oralMajor Pharmaceuticals2014-06-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet100 mg/1oralDIRECT RX2014-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet100 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated100 mg/1oralAvera Mc Kennan Hospital2015-03-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet25 mg/1oralREMEDYREPACK INC.2011-12-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet100 mg/1oralLupin Pharmaceuticals, Inc.2015-12-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet100 mg/1oralSTAT Rx USA LLC2010-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated25 mg/1oralAurobindo Pharma Limited2010-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated50 mg/1oralWatson Laboratories, Inc.2011-02-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet25 mg/1oralSt Marys Medical Park Pharmacy2014-04-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated100 mg/1oralREMEDYREPACK INC.2012-12-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated100 mg/1oralLegacy Pharmaceutical Packaging, Llc2010-04-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated50 mg/1oralPd Rx Pharmaceuticals, Inc.2010-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated50 mg/1oralAvera Mc Kennan Hospital2015-03-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet50 mg/1oralMajor Pharmaceuticals2014-06-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated50 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2010-10-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated25 mg/1oralTeva Pharmaceuticals USA Inc2010-04-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated100 mg/1oralCamber Pharmaceuticals, Inc.2015-08-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet100 mg/1oralPreferred Pharmaceuticals, Inc.2015-05-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet25 mg/1oralREMEDYREPACK INC.2011-07-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet50 mg/1oralLupin Pharmaceuticals, Inc.2015-12-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated100 mg/1oralRising Pharmaceuticals, Inc2014-07-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated100 mg/1oralCadila Healthcare Limited2010-10-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated25 mg/1oralWatson Laboratories, Inc.2011-02-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet25 mg/1oralDIRECT RX2015-12-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated25 mg/1oralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated50 mg/1oralCardinal Health2011-08-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet100 mg/1oralLegacy Pharmaceutical Packaging2010-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated25 mg/1oralPd Rx Pharmaceuticals, Inc.2010-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated100 mg/1oralVirtus Pharmaceuticals LLC2014-03-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet100 mg/1oralMajor Pharmaceuticals2014-06-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated25 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2010-10-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet100 mg/1oralRoxane Laboratories, Inc.2010-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated50 mg/1oralCamber Pharmaceuticals, Inc.2015-08-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet100 mg/1oralSt Marys Medical Park Pharmacy2013-07-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet50 mg/1oralREMEDYREPACK INC.2013-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated100 mg/1oralMedsource Pharmaceuticals2010-04-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated100 mg/1oralSandoz Inc2010-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet25 mg/1oralLupin Pharmaceuticals, Inc.2015-12-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated50 mg/1oralRising Pharmaceuticals, Inc2014-07-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated50 mg/1oralCadila Healthcare Limited2010-10-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated100 mg/1oralMylan Pharmaceuticals Inc.2012-12-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated100 mg/1oralMacleods Pharmaceuticals Limited2012-06-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet50 mg/1oralDIRECT RX2015-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated50 mg/1oralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated50 mg/1oralPreferred Pharmaceuticals, Inc.2013-01-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated25 mg/1oralLegacy Pharmaceutical Packaging, Llc2010-04-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet50 mg/1oralUnichem Pharmaceuticals (USA), Inc.2016-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated50 mg/1oralDispensing Solutions, Inc.2010-12-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated100 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-04-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated50 mg/1oralMicro Labs Limited2012-12-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated25 mg/1oralPhysicians Total Care, Inc.2010-04-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated50 mg/1oralApotex Corp2010-10-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated50 mg/1oralMc Kesson Contract Packaging2013-04-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet25 mg/1oralUnit Dose Services2010-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated50 mg/1oralVirtus Pharmaceuticals LLC2014-03-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated25 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-04-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated25 mg/1oralbryant ranch prepack2010-10-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet50 mg/1oralRoxane Laboratories, Inc.2010-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated25 mg/1oralCamber Pharmaceuticals, Inc.2015-08-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet50 mg/1oralSt Marys Medical Park Pharmacy2013-07-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet100 mg/1oralUnit Dose Services2010-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated50 mg/1oralLegacy Pharmaceutical Packaging, Llc2010-04-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated50 mg/1oralSandoz Inc2010-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet100 mg/1oralLupin Pharmaceuticals, Inc.2010-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated25 mg/1oralRising Pharmaceuticals, Inc2011-06-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated25 mg/1oralCadila Healthcare Limited2010-10-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated50 mg/1oralMylan Pharmaceuticals Inc.2012-12-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated50 mg/1oralMacleods Pharmaceuticals Limited2012-06-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated50 mg/1oralREMEDYREPACK INC.2015-09-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet25 mg/1oralREMEDYREPACK INC.2014-04-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated100 mg/1oralPreferred Pharmaceuticals, Inc.2013-01-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet25 mg/1oralLegacy Pharmaceutical Packaging2010-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet25 mg/1oralUnichem Pharmaceuticals (USA), Inc.2016-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated50 mg/1oralMed Vantx, Inc.2010-12-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated100 mg/1oralQualitest Pharmaceuticals2012-01-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated25 mg/1oralMicro Labs Limited2012-12-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated25 mg/1oralProficient Rx LP2010-04-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated100 mg/1oralPhysicians Total Care, Inc.2010-04-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet, film coated25 mg/1oralApotex Corp2010-10-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet50 mg/1oralLife Line Home Care Services, Inc.2010-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassiumtablet100 mg/1oralAv Pak2014-03-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassium Tablets, 100 mgtablet100 mg/1oralJubilant Cadista Pharmaceuticals Inc.2012-09-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassium Tablets, 25 mgtablet25 mg/1oralJubilant Cadista Pharmaceuticals Inc.2012-09-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potassium Tablets, 50 mgtablet50 mg/1oralJubilant Cadista Pharmaceuticals Inc.2012-09-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losartan Potatssiumtablet50 mg/1oralNew Horizon Rx Group, LLC2013-08-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losortan Potassiumtablet, film coated100 mg/1oralbryant ranch prepack2010-10-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losortan Potassiumtablet, film coated50 mg/1oralCardinal Health2010-10-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losortan Potassiumtablet, film coated25 mg/1oralREMEDYREPACK INC.2014-04-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losortan Potassiumtablet, film coated100 mg/1oralZydus Pharmaceuticals (USA) Inc.2010-10-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losortan Potassiumtablet, film coated25 mg/1oralRebel Distributors Corp2010-10-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losortan Potassiumtablet, film coated25 mg/1oralAidarex Pharmaceuticals LLC2010-10-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losortan Potassiumtablet, film coated50 mg/1oralZydus Pharmaceuticals (USA) Inc.2010-10-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losortan Potassiumtablet, film coated100 mg/1oralRebel Distributors Corp2010-10-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losortan Potassiumtablet, film coated100 mg/1oralProficient Rx LP2010-10-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losortan Potassiumtablet, film coated50 mg/1oralState of Florida DOH Central Pharmacy2014-11-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losortan Potassiumtablet, film coated100 mg/1oralAidarex Pharmaceuticals LLC2010-10-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losortan Potassiumtablet, film coated50 mg/1oralProficient Rx LP2010-10-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losortan Potassiumtablet, film coated25 mg/1oralZydus Pharmaceuticals (USA) Inc.2010-10-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losortan Potassiumtablet, film coated50 mg/1oralRebel Distributors Corp2010-10-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losortan Potassiumtablet, film coated50 mg/1oralAidarex Pharmaceuticals LLC2010-10-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losortan Potassiumtablet, film coated50 mg/1oralREMEDYREPACK INC.2013-06-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losortan Potassiumtablet, film coated50 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-10-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losortan Potassiumtablet, film coated100 mg/1oralCardinal Health2013-06-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losortan Potassiumtablet, film coated100 mg/1oralAmerican Health Packaging2013-06-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losortan Potassiumtablet, film coated100 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-10-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losortan Potassiumtablet, film coated50 mg/1oralAmerican Health Packaging2013-06-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losortan Potassiumtablet, film coated50 mg/1oralbryant ranch prepack2010-10-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losortan Potassiumtablet, film coated100 mg/1oralPd Rx Pharmaceuticals, Inc.2010-10-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losortan Potassiumtablet, film coated25 mg/1oralAmerican Health Packaging2013-06-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losortan Potassiumtablet, film coated25 mg/1oralCardinal Health2010-10-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Losortan Potassiumtablet, film coated50 mg/1oralMedsource Pharmaceuticals2010-10-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Over the Counter ProductsNot Available
International Brands
NameCompany
LortaanNot Available
Brand mixtures
NameLabellerIngredients
Act Losartan/hctActavis Pharma Company
Apo-losartan/hctzApotex Inc
Auro-losartan HctAuro Pharma Inc
HyzaarMerck Sharp & Dohme Corp.
Hyzaar 50/12.5mgMerck Canada Inc
Hyzaar DS 100/25 mgMerck Canada Inc
Jamp-losartan HctzJamp Pharma Corporation
Losartan Potassium and HydrochlorothiazideRoxane Laboratories, Inc.
Losartan-hctzPro Doc Limitee
Losartan/hctSivem Pharmaceuticals Ulc
Losartan/hctzSanis Health Inc
Mint-losartan/hctzMint Pharmaceuticals Inc
Mint-losartan/hctz DSMint Pharmaceuticals Inc
Mylan-losartan HctzMylan Pharmaceuticals Ulc
PMS-losartan-hctzPharmascience Inc
Ratio-losartan HctzTeva Canada Limited
Sandoz Losartan HctSandoz Canada Incorporated
Sandoz Losartan Hct DSSandoz Canada Incorporated
Septa-losartan HctzSepta Pharmaceuticals Inc
Teva-losartan/hctzTeva Canada Limited
Van-losartan-hctzVanc Pharmaceuticals Inc
Salts
Name/CASStructureProperties
Losartan Potassium
Thumb
  • InChI Key: OXCMYAYHXIHQOA-UHFFFAOYSA-N
  • Monoisotopic Mass: 460.118068924
  • Average Mass: 461.001
DBSALT000112
Categories
CAS number114798-26-4
WeightAverage: 422.911
Monoisotopic: 422.162187095
Chemical FormulaC22H23ClN6O
InChI KeyInChIKey=PSIFNNKUMBGKDQ-UHFFFAOYSA-N
InChI
InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
IUPAC Name
[2-butyl-4-chloro-1-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1H-imidazol-5-yl]methanol
SMILES
CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=C1)C1=CC=CC=C1C1=NNN=N1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as biphenyltetrazoles and derivatives. These are organic compounds containing a biphenyl attached to a tetrazole. A carbon atom of the biphenyl moiety is boned to a carbon or the nitrogen atom of the tetrazole moiety.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassAzoles
Sub ClassTetrazoles
Direct ParentBiphenyltetrazoles and derivatives
Alternative Parents
Substituents
  • Biphenyltetrazole
  • Biphenyl
  • 1,2,4,5-tetrasubstituted imidazole
  • Phenylmethylamine
  • Benzenoid
  • N-substituted imidazole
  • Monocyclic benzene moiety
  • Aryl halide
  • Aryl chloride
  • Heteroaromatic compound
  • Imidazole
  • Azacycle
  • Hydrocarbon derivative
  • Aromatic alcohol
  • Primary alcohol
  • Organooxygen compound
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Alcohol
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Pharmacology
IndicationMay be used as a first line agent to treat uncomplicated hypertension, isolated systolic hypertension and left ventricular hypertrophy. May be used as a first line agent to delay progression of diabetic nephropathy. Losartan may be also used as a second line agent in the treatment of congestive heart failure, systolic dysfunction, myocardial infarction and coronary artery disease in those intolerant of ACE inhibitors.
PharmacodynamicsLosartan is the first of a class of antihypertensive agents called angiotensin II receptor blockers (ARBs). Losartan and its longer acting active metabolite, E-3174, are specific and selective type-1 angiotensin II receptor (AT1) antagonists which block the blood pressure increasing effects angiotensin II via the renin-angiotensin-aldosterone system (RAAS). RAAS is a homeostatic mechanism for regulating hemodynamics, water and electrolyte balance. During sympathetic stimulation or when renal blood pressure or blood flow is reduced, renin is released from granular cells of the juxtaglomerular apparatus in the kidneys. Renin cleaves circulating angiotensinogen to angiotensin I, which is cleaved by angiotensin converting enzyme (ACE) to angiotensin II. Angiotensin II increases blood pressure by increasing total peripheral resistance, increasing sodium and water reabsorption in the kidneys via aldosterone secretion, and altering cardiovascular structure. Angiotensin II binds to two receptors: AT1 and type-2 angiotensin II receptor (AT2). AT1 is a G-protein coupled receptor (GPCR) that mediates the vasoconstrictive and aldosterone-secreting effects of angiotensin II. Studies performed in recent years suggest that AT2 antagonizes AT1-mediated effects and directly affects long-term blood pressure control by inducing vasorelaxation and increasing urinary sodium excretion. Angiotensin receptor blockers (ARBs) are non-peptide competitive inhibitors of AT1. ARBs block the ability of angiotensin II to stimulate pressor and cell proliferative effects. Unlike ACE inhibitors, ARBs do not affect bradykinin-induced vasodilation. The overall effect of ARBs is a decrease in blood pressure.
Mechanism of actionLosartan competitively inhibits the binding of angiotensin II to AT1 in many tissues including vascular smooth muscle and the adrenal glands. Losartan is metabolized to its active metabolite, E-3174, which is 10 to 40 times more potent than losartan and acts as a non-competitive AT1 antagonist. Inhibition of angiotensin II binding to AT1 inhibits its AT1-mediated vasoconstrictive and aldosterone-secreting effects and results in decreased vascular resistance and blood pressure. Losartan is 1,000 times more selective for AT1 than AT2. Inhibition of aldosterone secretion may increase sodium and water excretion while decreasing potassium excretion. Losartan is effective for reducing blood pressure and may be used to treat essential hypertension, left ventricular hypertrophy and diabetic nephropathy.
AbsorptionLosartan is well absorbed and undergoes substantial first-pass metabolism; the systemic bioavailability of losartan is approximately 33%. Mean peak concentrations of losartan and its active metabolite are reached in 1 hour and in 3-4 hours, respectively. While maximum plasma concentrations of losartan and its active metabolite are approximately equal, the AUC of the metabolite is about 4 times as great as that of losartan. When given with a meal, absorption is slows down and Cmax decreases.
Volume of distribution
  • 34 L [losartan, healthy subjects]
  • 12 L [active metabolite, healthy subjects]
Protein binding99.7% protein bound, primarily to albumin
Metabolism

Hepatic. Losartan is metabolized to a 5-carboxylic acid derivative (E-3174) via an aldehyde intermediate (E-3179) primarily by cytochrome P450 (CYP) 2C9 and CYP3A4. E-3174 is an active metabolite with 10- to 40-fold higher potency than its parent compound, losartan. Approxiamtely 14% of losartan is converted to E-3174; however, the AUC of E-3174 was found to be 4- to 8-fold higher than losartan and E-3174 is considered the main contributor to the pharmacologic effects of this medication.

SubstrateEnzymesProduct
Losartan
E-3179Details
Losartan
Losartan N2-glucuronideDetails
E-3179
E-3174Details
Route of eliminationFollowing oral administration of losartan, 35% of the dose is recovered in the urine and about 60% in the feces. Following an intravenous dose, 45% is recovered in the urine and 50% in the feces.
Half lifeThe terminal t1/2 of losartan is 2 hours. The active metabolite has a half-life of 6-9 hours.
Clearance
  • Total plasma clearance = 600 mL/min [losartan]
  • Total plasma clearance = 50 mL/min [active metabolite]
  • Renal clearance = 75 mL/min [losartan]
  • Renal clearance = 25 mL/min [active metabolite]
ToxicityHypotension and tachycardia; Bradycardia could occur from parasympathetic (vagal) stimulation, LD50= 1000 mg/kg (orally in rat)
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Losartan Action PathwayDrug actionSMP00162
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier-0.7812
Caco-2 permeable-0.8957
P-glycoprotein substrateSubstrate0.6993
P-glycoprotein inhibitor INon-inhibitor0.8782
P-glycoprotein inhibitor IIInhibitor0.5309
Renal organic cation transporterNon-inhibitor0.5689
CYP450 2C9 substrateNon-substrate0.6839
CYP450 2D6 substrateNon-substrate0.9115
CYP450 3A4 substrateNon-substrate0.6226
CYP450 1A2 substrateInhibitor0.5514
CYP450 2C9 inhibitorNon-inhibitor0.5423
CYP450 2D6 inhibitorNon-inhibitor0.8102
CYP450 2C19 inhibitorInhibitor0.6288
CYP450 3A4 inhibitorInhibitor0.796
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.7049
Ames testNon AMES toxic0.5382
CarcinogenicityNon-carcinogens0.6595
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.6055 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Strong inhibitor0.5781
hERG inhibition (predictor II)Inhibitor0.8084
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Merck research laboratories div merck co inc
  • Teva pharmaceuticals usa inc
  • Merck & Co., Inc.
Packagers
Dosage forms
FormRouteStrength
Tabletoral100 mg
Tabletoral25 mg
Tabletoral50 mg
Tablet, film coatedoral100 mg/1
Tablet, film coatedoral25 mg/1
Tablet, film coatedoral50 mg/1
Tablet, film coatedoral
Tabletoral100.0 mg
Tabletoral25.0 mg
Tabletoral50.0 mg
Tabletoral100 mg/1
Tabletoral25 mg/1
Tabletoral50 mg/1
Tabletoral
Prices
Unit descriptionCostUnit
Losartan Potassium 90 50 mg tablet Bottle211.78USD bottle
Losartan Potassium-HCTZ 30 50-12.5 mg tablet Bottle78.05USD bottle
Hyzaar 100-25 mg tablet3.91USD tablet
Hyzaar 100-12.5 mg tablet3.87USD tablet
Hyzaar 100-12.5 tablet3.61USD tablet
Hyzaar 100-25 tablet3.61USD tablet
Losartan Potassium-HCTZ 100-12.5 mg tablet3.54USD tablet
Losartan Potassium-HCTZ 100-25 mg tablet3.54USD tablet
Cozaar 100 mg tablet3.41USD tablet
Losartan potassium 100 mg tablet3.14USD tablet
Hyzaar 50-12.5 mg tablet2.97USD tablet
Hyzaar 50-12.5 tablet2.65USD tablet
Cozaar 50 mg tablet2.5USD tablet
Losartan potassium 50 mg tablet2.26USD tablet
Cozaar 25 mg tablet1.92USD tablet
Losartan potassium 25 mg tablet1.72USD tablet
Cozaar 100 mg Tablet1.31USD tablet
Cozaar 25 mg Tablet1.31USD tablet
Cozaar 50 mg Tablet1.31USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
CountryPatent NumberApprovedExpires (estimated)
Canada13340921995-01-242012-01-24
Canada20855842003-02-112011-06-07
United States52100791993-11-112010-11-11
United States56080751992-03-042009-03-04
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point184 °CPhysProp
water solubility0.82 mg/LNot Available
logP6.1Not Available
pKa5.5MERCK INDEX (1996); approx.
Predicted Properties
PropertyValueSource
Water Solubility0.0047 mg/mLALOGPS
logP4.5ALOGPS
logP5.08ChemAxon
logS-5ALOGPS
pKa (Strongest Acidic)7.4ChemAxon
pKa (Strongest Basic)4.12ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area92.51 Å2ChemAxon
Rotatable Bond Count8ChemAxon
Refractivity131.85 m3·mol-1ChemAxon
Polarizability44.86 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis Reference

Gordon C. Campbell, Jr., Anil M. Dwivedi, Dorothy A. Levorse, James A. McCauley, Krishnaswamy S. Raghavan, “Polymorphs of losartan and the process for the preparation of form II of losartan.” U.S. Patent US5608075, issued May, 1994.

US5608075
General References
  1. Dahlof B, Devereux RB, Kjeldsen SE, Julius S, Beevers G, de Faire U, Fyhrquist F, Ibsen H, Kristiansson K, Lederballe-Pedersen O, Lindholm LH, Nieminen MS, Omvik P, Oparil S, Wedel H: Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol. Lancet. 2002 Mar 23;359(9311):995-1003. Pubmed
  2. Guo ZX, Qiu MC: [Losartan downregulates the expression of transforming growth factor beta type I and type II receptors in kidney of diabetic rat] Zhonghua Nei Ke Za Zhi. 2003 Jun;42(6):403-8. Pubmed
  3. Habashi JP, Judge DP, Holm TM, Cohn RD, Loeys BL, Cooper TK, Myers L, Klein EC, Liu G, Calvi C, Podowski M, Neptune ER, Halushka MK, Bedja D, Gabrielson K, Rifkin DB, Carta L, Ramirez F, Huso DL, Dietz HC: Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science. 2006 Apr 7;312(5770):117-21. Pubmed
  4. Bader, M. (2004). Renin-angiotensin-aldosterone system. In S. Offermanns, & W. Rosenthal (Eds.). Encyclopedic reference of molecular pharmacology (pp. 810-814). Berlin, Germany: Springer.
  5. Sica, D.A., Gehr, T.W.B., & Ghosh, S. (2005). Clinical pharmacokinetics of losartan. Clinical Pharmacokinetics, 44(8), 797-814. PMID: 16029066
  6. Stanfield, C.L., & Germann, W.J. (2008). Principles of human physiology (3 rd ed.). San Francisco, CA: Pearson Education, Inc.
  7. FDA label
External Links
ATC CodesC09CA01
AHFS Codes
  • 24:32.08
PDB EntriesNot Available
FDA labelDownload (212 KB)
MSDSDownload (19 KB)
Interactions
Drug Interactions
Drug
AldesleukinThe risk or severity of adverse effects can be increased when Aldesleukin is combined with Losartan.
AlfuzosinAlfuzosin may increase the hypotensive activities of Losartan.
AliskirenAliskiren may increase the hyperkalemic activities of Losartan.
AmifostineLosartan may increase the hypotensive activities of Amifostine.
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Losartan.
ArdeparinArdeparin may increase the hyperkalemic activities of Losartan.
BexaroteneThe serum concentration of Losartan can be decreased when it is combined with Bexarotene.
BosentanThe serum concentration of Losartan can be decreased when it is combined with Bosentan.
BrimonidineBrimonidine may increase the antihypertensive activities of Losartan.
ButabarbitalButabarbital may increase the hypotensive activities of Losartan.
ButethalButethal may increase the hypotensive activities of Losartan.
CanagliflozinCanagliflozin may increase the hyperkalemic activities of Losartan.
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Losartan.
CeritinibThe serum concentration of Losartan can be increased when it is combined with Ceritinib.
CiprofloxacinLosartan may increase the arrhythmogenic activities of Ciprofloxacin.
CyclosporineLosartan may increase the hyperkalemic activities of Cyclosporine.
DabrafenibThe serum concentration of Losartan can be decreased when it is combined with Dabrafenib.
DapoxetineDapoxetine may increase the orthostatic hypotensive activities of Losartan.
DeferasiroxThe serum concentration of Losartan can be decreased when it is combined with Deferasirox.
DiazoxideDiazoxide may increase the hypotensive activities of Losartan.
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Losartan.
DrospirenoneLosartan may increase the hyperkalemic activities of Drospirenone.
DuloxetineLosartan may increase the orthostatic hypotensive activities of Duloxetine.
EplerenoneEplerenone may increase the hyperkalemic activities of Losartan.
FloxuridineThe metabolism of Losartan can be decreased when combined with Floxuridine.
FluconazoleThe serum concentration of Losartan can be decreased when it is combined with Fluconazole.
HeparinHeparin may increase the hyperkalemic activities of Losartan.
HeptabarbitalHeptabarbital may increase the hypotensive activities of Losartan.
HexobarbitalHexobarbital may increase the hypotensive activities of Losartan.
InfliximabThe risk or severity of adverse effects can be increased when Losartan is combined with Infliximab.
ItraconazoleThe metabolism of Losartan can be decreased when combined with Itraconazole.
KetoconazoleThe metabolism of Losartan can be decreased when combined with Ketoconazole.
LevodopaLosartan may increase the orthostatic hypotensive activities of Levodopa.
LithiumThe serum concentration of Lithium can be increased when it is combined with Losartan.
MethohexitalMethohexital may increase the hypotensive activities of Losartan.
MethylphenidateMethylphenidate may decrease the antihypertensive activities of Losartan.
MifepristoneThe serum concentration of Losartan can be increased when it is combined with Mifepristone.
MitotaneThe serum concentration of Losartan can be decreased when it is combined with Mitotane.
MolsidomineMolsidomine may increase the hypotensive activities of Losartan.
MoxonidineMoxonidine may increase the hypotensive activities of Losartan.
NicorandilNicorandil may increase the hypotensive activities of Losartan.
ObinutuzumabLosartan may increase the hypotensive activities of Obinutuzumab.
PentobarbitalPentobarbital may increase the hypotensive activities of Losartan.
PentoxifyllinePentoxifylline may increase the hypotensive activities of Losartan.
PerindoprilThe risk or severity of adverse effects can be increased when Losartan is combined with Perindopril.
PhenelzinePhenelzine may increase the orthostatic hypotensive activities of Losartan.
PhenytoinThe metabolism of Losartan can be increased when combined with Phenytoin.
PosaconazoleThe metabolism of Losartan can be decreased when combined with Posaconazole.
PrimidonePrimidone may increase the hypotensive activities of Losartan.
QuinineQuinine may increase the hypotensive activities of Losartan.
RifampicinThe serum concentration of Losartan can be decreased when it is combined with Rifampicin.
RisperidoneLosartan may increase the hypotensive activities of Risperidone.
RituximabLosartan may increase the hypotensive activities of Rituximab.
SecobarbitalSecobarbital may increase the hypotensive activities of Losartan.
SildenafilThe metabolism of Sildenafil can be decreased when combined with Losartan.
SiltuximabThe serum concentration of Losartan can be decreased when it is combined with Siltuximab.
St. John's WortThe serum concentration of Losartan can be decreased when it is combined with St. John's Wort.
SulfisoxazoleThe metabolism of Losartan can be decreased when combined with Sulfisoxazole.
TadalafilTadalafil may increase the antihypertensive activities of Losartan.
TizanidineThe serum concentration of Tizanidine can be increased when it is combined with Losartan.
TocilizumabThe serum concentration of Losartan can be decreased when it is combined with Tocilizumab.
TolvaptanTolvaptan may increase the hyperkalemic activities of Losartan.
TorasemideThe metabolism of Torasemide can be decreased when combined with Losartan.
TranylcypromineTranylcypromine may increase the orthostatic hypotensive activities of Losartan.
TreprostinilTreprostinil may increase the hypotensive activities of Losartan.
TriamtereneLosartan may increase the hyperkalemic activities of Triamterene.
TrimethoprimTrimethoprim may increase the hyperkalemic activities of Losartan.
ValsartanThe risk or severity of adverse effects can be increased when Valsartan is combined with Losartan.
VardenafilVardenafil may increase the antihypertensive activities of Losartan.
VoriconazoleThe metabolism of Losartan can be decreased when combined with Voriconazole.
YohimbineYohimbine may decrease the antihypertensive activities of Losartan.
Food Interactions
  • Take without regard to meals. Take at same time each day. Food delays absorption, but does not affect the extent of absorption.

Targets

1. Type-1 angiotensin II receptor

Kind: Protein

Organism: Human

Pharmacological action: yes

Actions: antagonist

Components

Name UniProt ID Details
Type-1 angiotensin II receptor P30556 Details

References:

  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. Pubmed
  2. Sardo MA, Castaldo M, Cinquegrani M, Bonaiuto M, Fontana L, Campo S, Campo GM, Altavilla D, Saitta A: Effects of AT1 receptor antagonist losartan on sICAM-1 and TNF-alpha levels in uncomplicated hypertensive patients. Angiology. 2004 Mar-Apr;55(2):195-203. Pubmed
  3. Dickstein K, Timmermans P, Segal R: Losartan: a selective angiotensin II type 1 (AT1) receptor antagonist for the treatment of heart failure. Expert Opin Investig Drugs. 1998 Nov;7(11):1897-914. Pubmed
  4. Anand-Srivastava MB, Palaparti A: Angiotensin-II-induced enhanced expression of Gi proteins is attenuated by losartan in A10 vascular smooth muscle cells: role of AT1 receptors. Can J Physiol Pharmacol. 2003 Feb;81(2):150-8. Pubmed
  5. Rocha I, Bras-Rosario L, Amparo-Barros M, Silva-Carvalho L: Angiotensin AT1 receptor antagonist losartan and the defence reaction in the anaesthetised rat. Effect on the carotid chemoreflex. Exp Physiol. 2003 May;88(3):309-14. Pubmed
  6. Guan J, Cheng DY, Chen XJ, Zhang Y, Wang H, Su QL: [The effects of losartan on pulmonary arterial collagen and AT1 in chronic hypoxic rats] Sichuan Da Xue Xue Bao Yi Xue Ban. 2004 Nov;35(6):774-7. Pubmed

Enzymes

1. Cytochrome P450 2C9

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Cytochrome P450 2C9 P11712 Details

References:

  1. Song JC, White CM: Pharmacologic, pharmacokinetic, and therapeutic differences among angiotensin II receptor antagonists. Pharmacotherapy. 2000 Feb;20(2):130-9. Pubmed
  2. Sica DA, Gehr TW, Ghosh S: Clinical pharmacokinetics of losartan. Clin Pharmacokinet. 2005;44(8):797-814. Pubmed
  3. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. Pubmed
  4. Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). Accessed May 28, 2010.
  5. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed
  6. Yasar U, Forslund-Bergengren C, Tybring G, Dorado P, Llerena A, Sjoqvist F, Eliasson E, Dahl ML: Pharmacokinetics of losartan and its metabolite E-3174 in relation to the CYP2C9 genotype. Clin Pharmacol Ther. 2002 Jan;71(1):89-98. Pubmed

2. Cytochrome P450 3A4

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Cytochrome P450 3A4 P08684 Details

References:

  1. Song JC, White CM: Pharmacologic, pharmacokinetic, and therapeutic differences among angiotensin II receptor antagonists. Pharmacotherapy. 2000 Feb;20(2):130-9. Pubmed
  2. Sica DA, Gehr TW, Ghosh S: Clinical pharmacokinetics of losartan. Clin Pharmacokinet. 2005;44(8):797-814. Pubmed
  3. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. Pubmed
  4. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

3. Cytochrome P450 3A5

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 3A5 P20815 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

4. Cytochrome P450 2C8

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Cytochrome P450 2C8 P10632 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

5. Cytochrome P450 2C19

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Cytochrome P450 2C19 P33261 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

6. Cytochrome P450 1A2

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Cytochrome P450 1A2 P05177 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

7. UDP-glucuronosyltransferase 1-1

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
UDP-glucuronosyltransferase 1-1 P22309 Details

References:

  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. Pubmed

8. UDP-glucuronosyltransferase 1-3

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
UDP-glucuronosyltransferase 1-3 P35503 Details

References:

  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. Pubmed

9. UDP-glucuronosyltransferase 1-10

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
UDP-glucuronosyltransferase 1-10 Q9HAW8 Details

References:

  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. Pubmed

10. UDP-glucuronosyltransferase 2B7

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
UDP-glucuronosyltransferase 2B7 P16662 Details

References:

  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. Pubmed

11. UDP-glucuronosyltransferase 2B17

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
UDP-glucuronosyltransferase 2B17 O75795 Details

References:

  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. Pubmed

Carriers

1. Serum albumin

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Serum albumin P02768 Details

References:

  1. FDA label

Transporters

1. Multidrug resistance protein 1

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Multidrug resistance protein 1 P08183 Details

References:

  1. Takara K, Kakumoto M, Tanigawara Y, Funakoshi J, Sakaeda T, Okumura K: Interaction of digoxin with antihypertensive drugs via MDR1. Life Sci. 2002 Feb 15;70(13):1491-500. Pubmed
  2. Borgnia MJ, Eytan GD, Assaraf YG: Competition of hydrophobic peptides, cytotoxic drugs, and chemosensitizers on a common P-glycoprotein pharmacophore as revealed by its ATPase activity. J Biol Chem. 1996 Feb 9;271(6):3163-71. Pubmed
  3. Soldner A, Benet LZ, Mutschler E, Christians U: Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and caco-2 cell monolayers. Br J Pharmacol. 2000 Mar;129(6):1235-43. Pubmed

2. Solute carrier family 22 member 6

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Solute carrier family 22 member 6 Q4U2R8 Details

References:

  1. Race JE, Grassl SM, Williams WJ, Holtzman EJ: Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). Biochem Biophys Res Commun. 1999 Feb 16;255(2):508-14. Pubmed

3. Solute carrier family 22 member 12

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Solute carrier family 22 member 12 Q96S37 Details

References:

  1. Lipkowitz MS: Regulation of uric acid excretion by the kidney. Curr Rheumatol Rep. 2012 Apr;14(2):179-88. doi: 10.1007/s11926-012-0240-z. Pubmed
  2. Burnier M, Roch-Ramel F, Brunner HR: Renal effects of angiotensin II receptor blockade in normotensive subjects. Kidney Int. 1996 Jun;49(6):1787-90. Pubmed

4. Solute carrier family 2, facilitated glucose transporter member 9

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Solute carrier family 2, facilitated glucose transporter member 9 Q9NRM0 Details

References:

  1. Lipkowitz MS: Regulation of uric acid excretion by the kidney. Curr Rheumatol Rep. 2012 Apr;14(2):179-88. doi: 10.1007/s11926-012-0240-z. Pubmed
  2. Burnier M, Roch-Ramel F, Brunner HR: Renal effects of angiotensin II receptor blockade in normotensive subjects. Kidney Int. 1996 Jun;49(6):1787-90. Pubmed

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Drug created on June 13, 2005 07:24 / Updated on September 16, 2013 17:11