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Identification
NameHydrochlorothiazide
Accession NumberDB00999  (APRD00092)
TypeSmall Molecule
GroupsApproved, Vet Approved
Description

A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It has been used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism. [PubChem]

Structure
Thumb
Synonyms
Esidrix
HCTZ
Microzide
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Ava-hydrochlorothiazidetablet50 mgoralAvanstra Inc2011-10-112014-08-21Canada
Ava-hydrochlorothiazidetablet25 mgoralAvanstra Inc2011-10-112014-08-21Canada
Ava-hydrochlorothiazidetablet12.5 mgoralAvanstra Inc2011-10-112014-08-21Canada
Bio-hydrochlorothiazidetablet100 mgoralBiomed PharmaNot applicableNot applicableCanada
Bio-hydrochlorothiazidetablet50 mgoralBiomed Pharma2003-04-11Not applicableCanada
Bio-hydrochlorothiazidetablet25 mgoralBiomed Pharma2003-04-11Not applicableCanada
Diuchlor H Tab 50mgtablet50 mgoralMedic Laboratory LtÉe1964-12-311996-09-09Canada
Dom-hydrochlorothiazidetablet50 mgoralBiomed Pharma2004-02-062013-08-02Canada
Dom-hydrochlorothiazidetablet25 mgoralBiomed Pharma2004-02-062013-08-02Canada
Dom-hydrochlorothiazidetablet12.5 mgoralDominion Pharmacal2006-08-022007-11-02Canada
Hydrochlorothiazidecapsule, gelatin coated12.5 mg/1oralActavis Pharma, Inc.1996-12-27Not applicableUs
Hydrochlorothiazidetablet25 mgoralSanis Health Inc2011-02-08Not applicableCanada
Hydrochlorothiazidecapsule, gelatin coated12.5 mg/1oralREMEDYREPACK INC.2014-07-14Not applicableUs
Hydrochlorothiazidecapsule, gelatin coated12.5 mg/1oralREMEDYREPACK INC.2013-03-27Not applicableUs
Hydrochlorothiazidecapsule, gelatin coated12.5 mg/1oralMc Kesson Contract Packaging1996-12-27Not applicableUs
Hydrochlorothiazidecapsule, gelatin coated12.5 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-11-21Not applicableUs
Hydrochlorothiazidecapsule, gelatin coated12.5 mg/1oralPreferred Pharmaceuticals Inc.2015-08-14Not applicableUs
Hydrochlorothiazidecapsule, gelatin coated12.5 mg/1oralSTAT Rx USA LLC1996-12-27Not applicableUs
Hydrochlorothiazidecapsule, gelatin coated12.5 mg/1oralbryant ranch prepack1996-12-27Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralBlenheim Pharmacal, Inc.2010-04-08Not applicableUs
Hydrochlorothiazidecapsule, gelatin coated12.5 mg/1oralProficient Rx LP1996-12-27Not applicableUs
Hydrochlorothiazidecapsule, gelatin coated12.5 mg/1oralBlenheim Pharmacal, Inc.2011-12-20Not applicableUs
Hydrochlorothiazidecapsule, gelatin coated12.5 mg/1oralPd Rx Pharmaceuticals, Inc.1996-12-27Not applicableUs
Hydrochlorothiazidecapsule, gelatin coated12.5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1996-12-27Not applicableUs
Hydrochlorothiazidetablet50 mgoralSanis Health Inc2011-02-08Not applicableCanada
Hydrochlorothiazide 100 Tabtablet100 mgoralPro Doc Limitee1981-12-312009-07-23Canada
Hydrochlorothiazide 100mg Tabletstablet100 mgoralLaboratoires Confab IncNot applicableNot applicableCanada
Hydrochlorothiazide 25mg Tabletstablet25 mgoralLaboratoires Confab IncNot applicableNot applicableCanada
Hydrochlorothiazide 50tablet50 mgoralPro Doc Limitee1972-12-312010-07-13Canada
Hydrochlorothiazide 50mg Tabletstablet50 mgoralLaboratoires Confab IncNot applicableNot applicableCanada
Hydrochlorothiazide Tab 25mgtablet25 mgoralPro Doc Limitee1975-12-31Not applicableCanada
Hydrochlorothiazide Tab 25mgtablet25 mgoralDuchesnay Inc1978-12-312003-07-18Canada
Hydrochlorothiazide Tab 50mgtablet50 mgoralDuchesnay Inc1978-12-312003-07-18Canada
Hydrochlorothiazide Tablets 25mgtablet25 mgoralD.C. Labs Limited1971-12-312003-07-11Canada
Hydrochlorothiazide Tablets 50mgtablet50 mgoralD.C. Labs Limited1971-12-312003-07-11Canada
Hydrodiuril Tab 100mgtablet100 mgoralMerck Frosst Canada & Cie, Merck Frosst Canada & Co.1976-12-311998-08-14Canada
Hydrodiuril Tab 25mgtablet25 mgoralMerck Frosst Canada & Cie, Merck Frosst Canada & Co.1959-12-312001-06-04Canada
Hydrodiuril Tab 50mgtablet50 mgoralMerck Frosst Canada & Cie, Merck Frosst Canada & Co.1959-12-312000-08-03Canada
Microzidecapsule, gelatin coated12.5 mg/1oralWatson Pharma, Inc.1996-12-27Not applicableUs
Mint-hydrochlorothiazidetablet50 mgoralMint Pharmaceuticals Inc2014-07-23Not applicableCanada
Mint-hydrochlorothiazidetablet25 mgoralMint Pharmaceuticals Inc2014-07-23Not applicableCanada
Mint-hydrochlorothiazidetablet12.5 mgoralMint Pharmaceuticals Inc2014-07-23Not applicableCanada
Neo Codema 25mgtablet25 mgoralNeolab Inc1960-12-311997-08-12Canada
Neo Codema 50mgtablet50 mgoralNeolab Inc1960-12-311997-08-12Canada
Ntp-hydrochlorothiazidetablet50 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-hydrochlorothiazidetablet25 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Nu-hydrotablet50 mgoralNu Pharm Inc2004-03-242012-09-04Canada
Nu-hydrotablet25 mgoralNu Pharm Inc2004-03-242012-09-04Canada
Nu-hydrotablet12.5 mgoralNu Pharm IncNot applicableNot applicableCanada
PHL-hydrochlorothiazidetablet12.5 mgoralPharmel Inc2006-07-212007-11-02Canada
PMS-hydrochlorothiazidetablet12.5 mgoralPharmascience Inc2005-12-22Not applicableCanada
PMS-hydrochlorothiazidetablet50 mgoralPharmascience Inc2003-12-10Not applicableCanada
PMS-hydrochlorothiazidetablet25 mgoralPharmascience Inc2003-12-10Not applicableCanada
PMS-hydrochlorothiazidetablet100 mgoralPharmascience IncNot applicableNot applicableCanada
Teva-hydrochlorothiazidetablet50 mgoralTeva Canada Limited1968-12-31Not applicableCanada
Teva-hydrochlorothiazidetablet25 mgoralTeva Canada Limited1968-12-31Not applicableCanada
Urozidetablet100 mgoralBiomed Pharma1979-12-31Not applicableCanada
Urozidetablet50 mgoralBiomed Pharma1973-12-31Not applicableCanada
Urozidetablet25 mgoralBiomed Pharma1985-10-18Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo Hydro Tab 100mgtablet100 mgoralApotex Inc1988-12-31Not applicableCanada
Apo Hydro Tab 25mgtablet25 mgoralApotex Inc1975-12-31Not applicableCanada
Apo Hydro Tab 50mgtablet50 mgoralApotex Inc1974-12-31Not applicableCanada
Apo-hydrotablet12.5 mgoralApotex Inc2009-07-02Not applicableCanada
Hydrochlorothiazidetablet50 mg/1oralA S Medication Solutions Llc2009-07-02Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralBlenheim Pharmacal, Inc.2010-12-01Not applicableUs
Hydrochlorothiazidecapsule12.5 mg/1oralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralVensun Pharmaceuticals, Inc.2014-10-18Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralH.J. Harkins Company, Inc.2010-08-20Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralUnichem Pharmaceuticals (USA), Inc.2009-07-02Not applicableUs
Hydrochlorothiazidecapsule12.5 mg/1oralHeritage Pharmaceuticals Inc.2010-12-10Not applicableUs
Hydrochlorothiazidecapsule, gelatin coated12.5 mg/1oralJUBILANT CADISTA PHARMACEUTICALS, INC.2008-02-11Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralLake Erie Medical DBA Quality Care Products LLC2009-07-02Not applicableUs
Hydrochlorothiazidetablet12.5 mg/1oralProficient Rx LP2013-01-15Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralPhysicians Total Care, Inc.1995-10-04Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralREMEDYREPACK INC.2015-06-01Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralContract Pharmacy Services Pa2010-11-09Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralGolden State Medical Supply, Inc2014-07-23Not applicableUs
Hydrochlorothiazidecapsule12.5 mg/1oralTYA Pharmaceuticals2010-12-10Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralLegacy Pharmaceutical Packaging, Llc1980-01-07Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralbryant ranch prepack2010-08-20Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralAphena Pharma Solutions Tennessee, Llc2002-03-29Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralAvera Mc Kennan Hospital2015-04-03Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralContract Pharmacy Services Pa2010-11-09Not applicableUs
Hydrochlorothiazidecapsule12.5 mg/1oralGreenstone LLC2007-09-192015-12-31Us
Hydrochlorothiazidetablet50 mg/1oralPreferred Pharmaceuticals Inc.2015-10-07Not applicableUs
Hydrochlorothiazidecapsule, gelatin coated12.5 mg/1oralNationwide Pharmaceutical, Llc2015-03-01Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2002-03-29Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralLiberty Pharmaceuticals, Inc.2008-01-29Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralWest ward Pharmaceutical Corp2006-08-01Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralA S Medication Solutions Llc2009-07-02Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralREMEDYREPACK INC.2011-07-20Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralREMEDYREPACK INC.2013-06-24Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralVensun Pharmaceuticals, Inc.2014-10-18Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralHeritage Pharmaceuticals Inc.2015-01-15Not applicableUs
Hydrochlorothiazidetablet12.5 mg/1oralMed Health Pharma, LLC2011-01-01Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralSTAT Rx USA LLC2010-04-02Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralPhysicians Total Care, Inc.1992-09-22Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralJUBILANT CADISTA PHARMACEUTICALS, INC.2007-10-26Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralPd Rx Pharmaceuticals, Inc.2006-08-01Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralProficient Rx LP2007-06-01Not applicableUs
Hydrochlorothiazidecapsule12.5 mg/1oralREMEDYREPACK INC.2015-04-16Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralDispensing Solutions, Inc.2003-03-29Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralReady Meds1980-11-05Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralLegacy Pharmaceutical Packaging, Llc1973-01-12Not applicableUs
Hydrochlorothiazidecapsule, gelatin coated12.5 mg/1oralRed Pharm Drug Inc.2002-09-17Not applicableUs
Hydrochlorothiazidetablet50 mg/50mgoralWestminster Pharmaceuticals, Llc2016-02-01Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralMc Kesson Contract Packaging2011-10-12Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2002-03-29Not applicableUs
Hydrochlorothiazidecapsule12.5 mg/1oralMylan Pharmaceuticals Inc.2012-08-07Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralA S Medication Solutions Llc2009-07-02Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralREMEDYREPACK INC.2011-05-09Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralREMEDYREPACK INC.2013-07-08Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralHeritage Pharmaceuticals Inc.2015-01-15Not applicableUs
Hydrochlorothiazidecapsule12.5 mg/1oralMylan Institutional Inc.2005-11-01Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralSTAT Rx USA LLC2002-03-29Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralA S Medication Solutions Llc2002-03-29Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralRebel Distributors Corp2010-08-20Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralUnichem Pharmaceuticals (USA), Inc.2009-07-02Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralJUBILANT CADISTA PHARMACEUTICALS, INC.2007-10-26Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralPd Rx Pharmaceuticals, Inc.2002-03-29Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralProficient Rx LP2007-06-01Not applicableUs
Hydrochlorothiazidecapsule12.5 mg/1oralREMEDYREPACK INC.2015-01-06Not applicableUs
Hydrochlorothiazidecapsule12.5 mg/1oralMed Vantx, Inc.2011-04-07Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralReady Meds1980-11-05Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralLegacy Pharmaceutical Packaging2002-03-29Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralDAVA Pharmaceuticals, Inc.1980-11-05Not applicableUs
Hydrochlorothiazidetablet25 mg/25mgoralWestminster Pharmaceuticals, Llc2016-02-01Not applicableUs
Hydrochlorothiazidecapsule12.5 mg/1oralLife Line Home Care Services, Inc.2012-02-08Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralQualitest Pharmaceuticals2002-03-29Not applicableUs
Hydrochlorothiazidetablet12.5 mg/1oralActavis Elizabeth LLC2007-03-12Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-03-28Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralREMEDYREPACK INC.2010-11-30Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralREMEDYREPACK INC.2013-08-21Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralRebel Distributors Corp1977-02-01Not applicableUs
Hydrochlorothiazidecapsule, gelatin coated12.5 mg/1oralUnit Dose Services2008-02-11Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralApotheca, Inc.2009-06-30Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralA S Medication Solutions Llc2002-03-29Not applicableUs
Hydrochlorothiazidecapsule, gelatin coated12.5 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralRebel Distributors Corp2010-08-16Not applicableUs
Hydrochlorothiazidetablet12.5 mg/1oralREMEDYREPACK INC.2013-03-18Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralProficient Rx LP2010-08-20Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralREMEDYREPACK INC.2014-10-24Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralMed Vantx, Inc.1973-01-12Not applicableUs
Hydrochlorothiazidecapsule12.5 mg/1oralReady Meds2010-03-15Not applicableUs
Hydrochlorothiazidecapsule, gelatin coated12.5 mg/1oralLegacy Pharmaceutical Packaging2002-09-17Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralDAVA Pharmaceuticals, Inc.1980-11-05Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralPreferred Pharmaceuticals, Inc.2015-05-05Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralQualitest Pharmaceuticals2002-03-29Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralKAISER FOUNDATION HOSPITALS2010-06-07Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralREMEDYREPACK INC.2012-03-15Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralAphena Pharma Solutions Tennessee, Llc2007-06-01Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralREMEDYREPACK INC.2013-05-13Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralRebel Distributors Corp2006-08-01Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralUnit Dose Services2007-05-01Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralApotheca, Inc.1996-12-21Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralInternational Labs, Inc.2011-08-01Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Hydrochlorothiazidecapsule12.5 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-03-15Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralREMEDYREPACK INC.2013-03-01Not applicableUs
Hydrochlorothiazidecapsule12.5 mg/1oralClinical Solutions Wholesale2010-03-15Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralCardinal Health1982-01-01Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralCarilion Materials Management1980-01-07Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralContract Pharmacy Services Pa2010-08-16Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralPreferred Pharmaceuticals, Inc.2012-01-30Not applicableUs
Hydrochlorothiazidecapsule, gelatin coated12.5 mg/1oralQualitest Pharmaceuticals2002-09-17Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralIVAX Pharmaceuticals, Inc.1980-01-07Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralREMEDYREPACK INC.2011-09-27Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralAphena Pharma Solutions Tennessee, Llc2007-06-01Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralREMEDYREPACK INC.2013-02-09Not applicableUs
Hydrochlorothiazidetablet12.5 mg/1oralRebel Distributors Corp2007-02-27Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralUnit Dose Services2010-08-20Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralBlenheim Pharmacal, Inc.2015-04-06Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralInternational Labs, Inc.2011-08-01Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-08-01Not applicableUs
Hydrochlorothiazidecapsule12.5 mg/1oralHeritage Pharmaceuticals Inc2009-06-20Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralClinical Solutions Wholesale2010-03-15Not applicableUs
Hydrochlorothiazidecapsule12.5 mg/1oralCardinal Health2010-10-29Not applicableUs
Hydrochlorothiazidecapsule12.5 mg/1oralDIRECT RX2014-01-01Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralSt Marys Medical Park Pharmacy2013-07-10Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralAurobindo Pharma Limited2007-07-20Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralExcellium Pharmaceutical Inc.2007-06-01Not applicableUs
Hydrochlorothiazidecapsule12.5 mg/1oralLannett Company, Inc.2012-01-27Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralIVAX Pharmaceuticals, Inc.1973-01-12Not applicableUs
Hydrochlorothiazidecapsule12.5 mg/1oralREMEDYREPACK INC.2011-08-30Not applicableUs
Hydrochlorothiazidecapsule, gelatin coated12.5 mg/1oralAphena Pharma Solutions Tennessee, Llc2002-09-17Not applicableUs
Hydrochlorothiazidetablet12.5 mg/1oralNorthwind Pharmaceuticals, LLC2015-03-06Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralAccord Healthcare Inc.2013-01-15Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralScie Gen Pharmaceuticals, Inc.2014-02-05Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralBlenheim Pharmacal, Inc.2013-10-01Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralInternational Laboratories, Inc.2015-03-16Not applicableUs
Hydrochlorothiazidecapsule, gelatin coated12.5 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Hydrochlorothiazidecapsule, gelatin coated12.5 mg/1oralAidarex Pharmaceuticals LLC2002-09-17Not applicableUs
Hydrochlorothiazidetablet12.5 mg/1oralHeritage Pharmaceuticals Inc.2011-01-03Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralClinical Solutions Wholesale2010-03-15Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralCardinal Health2012-04-02Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralDIRECT RX2015-01-01Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralSt Marys Medical Park Pharmacy2007-05-01Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralAurobindo Pharma Limited2007-07-20Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralExcellium Pharmaceutical Inc.2007-06-01Not applicableUs
Hydrochlorothiazidecapsule12.5 mg/1oralAmerican Health Packaging2013-07-08Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralContract Pharmacy Services Pa2010-08-16Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralPreferred Pharmaceuticals, Inc.2012-01-30Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralLannett Company, Inc.2007-05-01Not applicableUs
Hydrochlorothiazidecapsule12.5 mg/1oralWest ward Pharmaceutical Corp2007-11-26Not applicableUs
Hydrochlorothiazidecapsule12.5 mg/1oralREMEDYREPACK INC.2011-05-13Not applicableUs
Hydrochlorothiazidecapsule12.5 mg/1oralPd Rx Pharmaceuticals, Inc.2012-01-27Not applicableUs
Hydrochlorothiazidetablet12.5 mg/1oralNorthwind Pharmaceuticals, LLC2014-09-14Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralAccord Healthcare Inc.2013-01-15Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralScie Gen Pharmaceuticals, Inc.2014-07-23Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralBlenheim Pharmacal, Inc.2013-03-28Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralInternational Laboratories, Inc.2015-05-01Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralAidarex Pharmaceuticals LLC2002-03-29Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralHeritage Pharmaceuticals Inc.2010-08-20Not applicableUs
Hydrochlorothiazidecapsule12.5 mg/1oralSun Pharmaceutical Industries, Inc.2014-04-17Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralCardinal Health2007-06-28Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralREMEDYREPACK INC.2015-12-23Not applicableUs
Hydrochlorothiazidecapsule12.5 mg/1oralSt Marys Medical Park Pharmacy2013-05-15Not applicableUs
Hydrochlorothiazidecapsule12.5 mg/1oralAurobindo Pharma Limited2007-09-19Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2002-03-29Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralAmerican Health Packaging2012-04-02Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralContract Pharmacy Services Pa2010-03-09Not applicableUs
Hydrochlorothiazidecapsule12.5 mg/1oralPreferred Pharmaceuticals, Inc.2012-07-27Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralREMEDYREPACK INC.2013-10-08Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralPd Rx Pharmaceuticals, Inc.2002-03-29Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralNorthwind Pharmaceuticals, LLC2014-08-21Not applicableUs
Hydrochlorothiazidetablet12.5 mg/1oralAccord Healthcare Inc.2013-01-15Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralA S Medication Solutions Llc2007-07-20Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralBlenheim Pharmacal, Inc.2011-06-15Not applicableUs
Hydrochlorothiazidecapsule12.5 mg/1oralState of Florida DOH Central Pharmacy2014-11-01Not applicableUs
Hydrochlorothiazidecapsule12.5 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Hydrochlorothiazidecapsule12.5 mg/1oralUnichem Pharmaceuticals (USA), Inc.2010-03-15Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralHeritage Pharmaceuticals Inc.2010-08-20Not applicableUs
Hydrochlorothiazidecapsule12.5 mg/1oralCitron Pharma LLC2007-09-19Not applicableUs
Hydrochlorothiazidecapsule12.5 mg/1oralPhysicians Total Care, Inc.2002-05-23Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralREMEDYREPACK INC.2015-09-17Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralGolden State Medical Supply, Inc2014-07-23Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralTYA Pharmaceuticals2010-08-20Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralbryant ranch prepack2010-08-20Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralAphena Pharma Solutions Tennessee, Llc2002-03-29Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralContract Pharmacy Services Pa2010-03-09Not applicableUs
Hydrochlorothiazidecapsule12.5 mg/1oralBlenheim Pharmacal, Inc.2013-10-07Not applicableUs
Hydrochlorothiazidetablet12.5 mg/1oralPreferred Pharmaceuticals, Inc.2014-06-16Not applicableUs
Hydrochlorothiazidetablet12.5 mg/1oralREMEDYREPACK INC.2016-03-14Not applicableUs
Hydrochlorothiazidetablet25 mg/1oralLannett Company, Inc.2007-05-01Not applicableUs
Hydrochlorothiazidetablet50 mg/1oralWest ward Pharmaceutical Corp1977-02-01Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
DichlotrideM & H
EsidrexNovartis
HydrodiurilMerck
HydroDIURILMerck
Brand mixtures
NameLabellerIngredients
AccureticParke Davis Div Of Pfizer Inc
Accuretic 10/12.5 mgPfizer Canada Inc
Accuretic 20/12.5 mgPfizer Canada Inc
Accuretic 20/25 mgPfizer Canada Inc
Ach-telmisartan HctzAccord Healthcare Inc
Act Candesartan/hctActavis Pharma Company
Act Irbesartan/hctActavis Pharma Company
Act Losartan/hctActavis Pharma Company
Act Telmisartan/hctActavis Pharma Company
AldactazideG.D. Searle LLC Division of Pfizer Inc
Aldactazide 25Pfizer Canada Inc
Aldactazide 50Pfizer Canada Inc
Aldoril 15 TabMerck Frosst Canada & Cie, Merck Frosst Canada & Co.
Aldoril 25 TabMerck Frosst Canada & Cie, Merck Frosst Canada & Co.
Altace HctValeant Canada Lp Valeant Canada S.E.C.
Alti-amiloride HctzAltimed Pharma Inc.
Ami-hydro TabPro Doc Limitee
Amiloride Hydrochloride and HydrochlorothiazideMylan Pharmaceuticals Inc.
Amlodipine, Valsartan and HydrochlorothiazideTorrent Pharmaceuticals Limited
Amlodipine, Valsartan, and HydrochlorothiazideTeva Pharmaceuticals USA Inc
Amlodipine, Valsartan, HydrochlorothiazideSandoz Inc
AmturnideNovartis Pharmaceuticals Corporation
Apo Methazide 15Apotex Inc
Apo Methazide 25Apotex Inc
Apo TriazideApotex Inc
Apo-amilzide TabApotex Inc
Apo-candesartan/hctzApotex Inc
Apo-cilazapril/hctzApotex Inc
Apo-enalapril Maleate/hctzApotex Inc
Apo-irbesartan/hctzApotex Inc
Apo-lisinopril/hctzApotex Inc
Apo-losartan/hctzApotex Inc
Apo-quinapril/hctzApotex Inc
Apo-ramipril/hctzApotex Inc
Apo-spirozide TabApotex Inc
Apo-telmisartan/hctzApotex Inc
Apo-valsartan/hctzApotex Inc
Atacand HctAstra Zeneca Lp
Atacand PlusAstrazeneca Canada Inc
Auro-candesartan HctAuro Pharma Inc
Auro-irbesartan HctAuro Pharma Inc
Auro-losartan HctAuro Pharma Inc
Auro-valsartan HctAuro Pharma Inc
Ava-irbesartan/hctzAvanstra Inc
Ava-lisinopril HctAvanstra Inc
Ava-valsartan HctAvanstra Inc
AvalideSanofi Aventis U.S. Llc
Avalide 150/12.5 mgSanofi Aventis Canada Inc
Avalide 300/12.5 mgSanofi Aventis Canada Inc
Benazepril Hydrochloride and HydrochlorothiazideEon Labs, Inc.
Benicar HctLake Erie Medical & Surgical Supply DBA Quality Care Products LLC
Bisoprolol Fumarate and HydrochlorothiazideEon Labs, Inc.
Candesartan Cilexetil and HydrochlorothiazideMylan Pharmaceuticals Inc.
Candesartan Cilexetil and Hydrochlorothiazide TabletsAlembic Pharmaceuticals Limited
Candesartan Cilexetil-hydrochlorothiazidePar Pharmaceutical Inc.
Candesartan HctSivem Pharmaceuticals Ulc
Candesartan-hctzPro Doc Limitee
Candesartan/hctzSanis Health Inc
Captopril and HydrochlorothiazideMylan Phamaceuticals Inc.
Diovan HctNovartis Pharmaceuticals Corporation
Diovan-hctNovartis Pharmaceuticals Canada Inc
Dom-irbesartan-hctzDominion Pharmacal
DutoprolAstra Zeneca Lp
DyazideGlaxo Smith Kline Llc
Dyazide TabSmithkline Beecham Pharma Division Of Smithkline Beecham Inc
Enalapril Maleate and HydrochlorothiazideTeva Pharmaceuticals USA Inc
Enalapril/hctzFrosst A Division Of Merck Canada Inc
Exforge HctNovartis Pharmaceuticals Corporation
Fosinopril Sodium and HydrochlorothiazideEon Labs, Inc.
Gd-quinapril HctzGenmed A Division Of Pfizer Canada Inc
Hydropres 25 TabMerck Frosst Canada & Cie, Merck Frosst Canada & Co.
Hydropres 50 TabMerck Frosst Canada & Cie, Merck Frosst Canada & Co.
HyzaarMerck Sharp & Dohme Corp.
Hyzaar 50/12.5mgMerck Canada Inc
Hyzaar DS 100/25 mgMerck Canada Inc
Inderide-40 TabWyeth Ayerst Canada Inc.
Inderide-80 TabWyeth Ayerst Canada Inc.
Inhibace Plus - TabHoffmann La Roche Limited
Ipg-candesartan + HctInternational Pharmaceutical Generics Ltd
Irbesartan and HydrochlorothiazideRoxane Laboratories, Inc.
Irbesartan HctSivem Pharmaceuticals Ulc
Irbesartan-hctzPro Doc Limitee
Irbesartan/hctActavis Pharma Company
Irbesartan/hctzSanis Health Inc
Jamp-irbesartan and HydrochlorothiazideJamp Pharma Corporation
Jamp-losartan HctzJamp Pharma Corporation
Lisinopril and HctzNorthwind Pharmaceuticals, LLC
Lisinopril and HydrochlorothiazideIVAX Pharmaceuticals, Inc.
Lisinopril and HydrochlorthiazideREMEDYREPACK INC.
Lisinopril With HydrochlorothiazideWest Ward Pharmaceuticals Corp
Lisinopril/hctz (type Z)Sanis Health Inc
Lisnopril/hctz (type P)Sanis Health Inc
Lopressor HctValidus Pharmaceuticals LLC
Losartan Potassium and HydrochlorothiazideRoxane Laboratories, Inc.
Losartan-hctzPro Doc Limitee
Losartan/hctSivem Pharmaceuticals Ulc
Losartan/hctzSanis Health Inc
Lotensin HctValidus Pharmaceuticals LLC
MaxzideMylan Pharmaceuticals Inc.
Maxzide-25Mylan Pharmaceuticals Inc.
Methyldopa and HydrochlorothiazideMylan Pharmaceuticals Inc.
Metoprolol Tartrate and HydrochlorothiazideMylan Pharmaceuticals Inc.
Metoprolol Tartrate and Hydrochlorothiazide 100 Mg-25 mgNorth Star Rx Llc
Metoprolol Tartrate and Hydrochlorothiazide 100 Mg-50 mgNorth Star Rx Llc
Metoprolol Tartrate and Hydrochlorothiazide 50 Mg-25 mgNorth Star Rx Llc
Micardis HctBoehringer Ingelheim Pharmaceuticals, Inc.
Micardis PlusBoehringer Ingelheim (Canada) Ltd Ltee
Mint-irbesartan/hctzMint Pharmaceuticals Inc
Mint-losartan/hctzMint Pharmaceuticals Inc
Mint-losartan/hctz DSMint Pharmaceuticals Inc
ModuretPrempharm Inc
Moexipril Hydrochloride and HydrochlorothiazideTeva Pharmaceuticals USA Inc
Mylan-amilazideMylan Pharmaceuticals Ulc
Mylan-candesartan HctzMylan Pharmaceuticals Ulc
Mylan-irbesartan HctzMylan Pharmaceuticals Ulc
Mylan-lisinopril HctzMylan Pharmaceuticals Ulc
Mylan-losartan HctzMylan Pharmaceuticals Ulc
Mylan-telmisartan HctzMylan Pharmaceuticals Ulc
Mylan-valsartan HctzMylan Pharmaceuticals Ulc
NovamilorTeva Canada Limited
Novo-cilazapril/hctzTeva Canada Limited
Novo-doparil 15 TabNovopharm Limited
Novo-doparil 25 TabNovopharm Limited
Novo-valsartan/hctzTeva Canada Limited
Ntp-irbesartan/hctzTeva Canada Limited
Ntp-lisinopril/hctz (type P)Teva Canada Limited
Ntp-lisinopril/hctz (type Z)Teva Canada Limited
Ntp-telmisartan HctzTeva Canada Limited
Nu-amilzide 5/50 Mg TabNu Pharm Inc
Nu-lisinopril/hctzNu Pharm Inc
Nu-triazide Tab 50 Mg/25 mgNu Pharm Inc
Pendo-irbesartan-hctzPendopharm Division Of De Pharmascience Inc
Pendo-telmisartan-hctzPendopharm Division Of De Pharmascience Inc
Penta-amiloride Hctz TabletsPentapharm Ltd.
Penta-triamterene Hctz TabletsPentapharm Ltd.
PMS-candesartan HctzPharmascience Inc
PMS-dopazide 15 TabPharmascience Inc
PMS-dopazide-25 TabPharmascience Inc
PMS-irbesartan-hctzPharmascience Inc
PMS-losartan-hctzPharmascience Inc
PMS-ramipril-hctzPharmascience Inc
PMS-telmisartan-hctzPharmascience Inc
PMS-valsartan-hctzPharmascience Inc
PrinzideMerck Canada Inc
Pro-triazidePro Doc Limitee
Propranolol Hydrochloride and HydrochlorothiazideMylan Pharmaceuticals Inc.
Q-valsartan HctzQd Pharmaceuticals Ulc
Quinapril HCl and HydrochlorothiazideGavis Pharmaceuticals, LLC.
Quinapril Hydrochloride and HydrochlorothiazideMylan Pharmaceuticals Inc.
Quinapril Hydrochloride/hydrochlorothiazideLake Erie Medical DBA Quality Care Products LLC
Ramipril-hctzSanis Health Inc
Ran-irbesartan HctzRanbaxy Pharmaceuticals Canada Inc.
Ran-ramipril HctzRanbaxy Pharmaceuticals Canada Inc.
Ran-telmisartan HctzRanbaxy Pharmaceuticals Canada Inc.
Rasilez HctNovartis Pharmaceuticals Canada Inc
Ratio-irbesartan HctzTeva Canada Limited
Ratio-losartan HctzTeva Canada Limited
Riva-amilzide 5/50 mgLaboratoire Riva Inc
Riva-zide 50/25mg TabletsLaboratoire Riva Inc
Sandoz Candesartan PlusSandoz Canada Incorporated
Sandoz Irbesartan HctSandoz Canada Incorporated
Sandoz Lisinopril HctSandoz Canada Incorporated
Sandoz Losartan HctSandoz Canada Incorporated
Sandoz Losartan Hct DSSandoz Canada Incorporated
Sandoz Telmisartan HctSandoz Canada Incorporated
Sandoz Valsartan HctSandoz Canada Incorporated
Septa-candesartan HctzSepta Pharmaceuticals Inc
Septa-losartan HctzSepta Pharmaceuticals Inc
Ser-AP-ES TabNovartis Pharmaceuticals Canada Inc
Spironolactone and HydrochlorothiazideMylan Pharmaceuticals Inc.
Tekturna HctNovartis Pharmaceuticals Corporation
Telmisartan and HydrochlorothiazideRoxane Laboratories, Inc.
Telmisartan and Hydrochlorothiazide 40 Mg/12.5 mgAlembic Pharmaceuticals Limited
Telmisartan and Hydrochlorothiazide 80 Mg/12.5 mgAlembic Pharmaceuticals Limited
Telmisartan and Hydrochlorothiazide 80 Mg/25 mgAlembic Pharmaceuticals Limited
Telmisartan and HydrochlorthiazideTorrent Pharmaceuticals Limited
Telmisartan HctzSivem Pharmaceuticals Ulc
Telmisartan-hctzPro Doc Limitee
Telmisartan/hctzSanis Health Inc
Teva-candesartan/hctzTeva Canada Limited
Teva-enalapril/hctzTeva Canada Limited
Teva-irbesartan/hctzTeva Canada Limited
Teva-lisinopril/hctz (type P)Teva Canada Limited
Teva-lisinopril/hctz (type Z)Teva Canada Limited
Teva-losartan/hctzTeva Canada Limited
Teva-ramipril/hctzTeva Canada Limited
Teva-spironolactone/hctzTeva Canada Limited
Teva-telmisartan HctzTeva Canada Limited
Teva-triamterene/hctzTeva Canada Limited
Teva-valsartan/hctzTeva Canada Limited
Teveten HctAbb Vie Inc.
Teveten PlusBgp Pharma Ulc
Timolide TabMerck Frosst Canada & Cie, Merck Frosst Canada & Co.
Torrent-telmisartan and HydrochlorothiazideTorrent Pharmaceuticals Limited
Triamterene and HydrochlorothiazideKAISER FOUNDATION HOSPITALS
Triamterene HydrochlorothiazideKAISER FOUNDATION HOSPITALS
TribenzorDaiichi Sankyo, Inc.
Valsartan and HydrochlorothiazideMylan Pharmaceuticals Inc.
Valsartan HctSanis Health Inc
Valsartan HctzNorthwind Pharmaceuticals
Valsartan-hctzPro Doc Limitee
Van-irbesartan-hctzVanc Pharmaceuticals Inc
Van-losartan-hctzVanc Pharmaceuticals Inc
Van-telmisartan-hctzVanc Pharmaceuticals Inc
VasereticValeant Pharmaceuticals North America LLC
Viskazide 10/25tabTribute Pharmaceuticals Canada Inc
Viskazide 10/50tabTribute Pharmaceuticals Canada Inc
ZestoreticAstra Zeneca Pharmaceuticals Lp
Zestoretic Tab 10/12.5mgAstrazeneca Canada Inc
Zestoretic Tab 20/12.5mgAstrazeneca Canada Inc
Zestoretic Tab 20/25mgAstrazeneca Canada Inc
ZiacTeva Women's Health, Inc.
Zinda-candesartan/hydrochlorothiazideZinda Pharma Limited
Zinda-telmisartan/ HctzZinda Pharma Limited
SaltsNot Available
Categories
UNII0J48LPH2TH
CAS number58-93-5
WeightAverage: 297.739
Monoisotopic: 296.964474846
Chemical FormulaC7H8ClN3O4S2
InChI KeyInChIKey=JZUFKLXOESDKRF-UHFFFAOYSA-N
InChI
InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)
IUPAC Name
6-chloro-1,1-dioxo-3,4-dihydro-2H-1λ⁶,2,4-benzothiadiazine-7-sulfonamide
SMILES
NS(=O)(=O)C1=C(Cl)C=C2NCNS(=O)(=O)C2=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as benzothiadiazines. These are organic compounds containing a benzene fused to a thiadiazine ring (a six-member ring with two nitrogen atoms and a sulfur atom).
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassThiadiazines
Sub ClassBenzothiadiazines
Direct ParentBenzothiadiazines
Alternative Parents
Substituents
  • Benzothiadiazine
  • Benzenesulfonamide
  • Secondary aliphatic/aromatic amine
  • Chlorobenzene
  • Benzenoid
  • Aryl halide
  • Aryl chloride
  • Aminosulfonyl compound
  • Sulfonyl
  • Sulfonic acid derivative
  • Sulfonamide
  • Azacycle
  • Secondary amine
  • Hydrocarbon derivative
  • Organosulfur compound
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationFor the treatment of high blood pressure and management of edema.
PharmacodynamicsThiazides such as hydrochlorothiazide promote water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.
Mechanism of actionHydrochlorothiazide, a thiazide diuretic, inhibits water reabsorption in the nephron by inhibiting the sodium-chloride symporter (SLC12A3) in the distal convoluted tubule, which is responsible for 5% of total sodium reabsorption. Normally, the sodium-chloride symporter transports sodium and chloride from the lumen into the epithelial cell lining the distal convoluted tubule. The energy for this is provided by a sodium gradient established by sodium-potassium ATPases on the basolateral membrane. Once sodium has entered the cell, it is transported out into the basolateral interstitium via the sodium-potassium ATPase, causing an increase in the osmolarity of the interstitium, thereby establishing an osmotic gradient for water reabsorption. By blocking the sodium-chloride symporter, hydrochlorothiazide effectively reduces the osmotic gradient and water reabsorption throughout the nephron.
Related Articles
Absorption50-60%
Volume of distributionNot Available
Protein binding67.9%
Metabolism

Hydrochlorothiazide is not metabolized.

Route of eliminationHydrochlorothiazide is not metabolized but is eliminated rapidly by the kidney. Hydrochlorothiazide crosses the placental but not the blood-brain barrier and is excreted in breast milk.
Half life5.6 and 14.8 hours
ClearanceNot Available
ToxicityThe most common signs and symptoms observed are those caused by electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration resulting from excessive diuresis. If digitalis has also been administered, hypokalemia may accentuate cardiac arrhythmias. The oral LD50 of hydrochlorothiazide is greater than 10 g/kg in the mouse and rat.
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Hydrochlorothiazide Action PathwayDrug actionSMP00100
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9202
Blood Brain Barrier-0.9659
Caco-2 permeable-0.8956
P-glycoprotein substrateNon-substrate0.6533
P-glycoprotein inhibitor INon-inhibitor0.8624
P-glycoprotein inhibitor IINon-inhibitor0.8688
Renal organic cation transporterNon-inhibitor0.8416
CYP450 2C9 substrateNon-substrate0.7664
CYP450 2D6 substrateNon-substrate0.8333
CYP450 3A4 substrateNon-substrate0.6217
CYP450 1A2 substrateNon-inhibitor0.9401
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorNon-inhibitor0.9252
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.9569
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9036
Ames testNon AMES toxic0.9133
CarcinogenicityNon-carcinogens0.7986
BiodegradationNot ready biodegradable0.9964
Rat acute toxicity2.0666 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9576
hERG inhibition (predictor II)Non-inhibitor0.9135
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Apotex inc
  • Aurobindo pharma ltd
  • Cadista pharmaceuticals inc
  • Ipca laboratories ltd
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Mylan pharmaceuticals inc
  • Unichem laboratories ltd
  • Vintage pharmaceuticals inc
  • West ward pharmaceutical corp
  • Watson laboratories inc
  • Morton grove pharmaceuticals inc
  • Roxane laboratories inc
  • Novartis pharmaceuticals corp
  • Abc holding corp
  • Actavis elizabeth llc
  • Alra laboratories inc
  • Ascot hosp pharmaceuticals inc div travenol laboratories inc
  • Barr laboratories inc
  • Caraco pharmaceutical laboratories ltd
  • Dava pharmaceuticals inc
  • Elkins sinn div ah robins co inc
  • Excellium pharmaceutical inc
  • Heather drug co inc
  • Heritage pharmaceuticals inc
  • Impax laboratories inc
  • Inwood laboratories inc sub forest laboratories inc
  • Lannett holdings inc
  • Mm mast and co
  • Mutual pharmaceutical co inc
  • Private formulations inc
  • Sandoz inc
  • Solvay pharmaceuticals
  • Superpharm corp
  • Teva pharmaceuticals usa inc
  • Tg united labs llc
  • Usl pharma inc
  • Vangard laboratories inc div midway medical co
  • Warner chilcott div warner lambert co
  • Whiteworth towne paulsen inc
  • Halsey drug co inc
  • Merck and co inc
  • Abbott laboratories pharmaceutical products div
Packagers
Dosage forms
FormRouteStrength
Tablet, coatedoral
Capsuleoral
Capsuleoral12.5 mg/1
Capsule, gelatin coatedoral12.5 mg/1
Tabletoral12.5 mg/1
Tabletoral25 mg/1
Tabletoral25 mg/25mg
Tabletoral50 mg/50mg
Tabletoral50 mg/1
Tablet, film coatedoral
Tabletoral
Tabletoral12.5 mg
Tabletoral100 mg
Tabletoral25 mg
Tabletoral50 mg
Prices
Unit descriptionCostUnit
Niferex-150 Forte 100 80-70 mg capsule Box109.86USD box
Niferex 100 mg/5ml Elixir 236ml Bottle80.55USD bottle
Niferex 100 40-20 mg capsule Box77.99USD box
Capozide 50-25 mg tablet3.63USD tablet
Ziac 10-6.25 mg tablet3.6USD tablet
Ziac 2.5-6.25 mg tablet3.6USD tablet
Ziac 5-6.25 mg tablet3.6USD tablet
Capozide 50-15 tablet3.49USD tablet
Capozide 50-25 tablet3.49USD tablet
Capozide 50-15 mg tablet2.59USD tablet
Lotensin 20 mg tablet2.25USD tablet
Lotensin 10 mg tablet2.09USD tablet
Lotensin 40 mg tablet2.09USD tablet
Lotensin 5 mg tablet2.09USD tablet
Accuretic 20-12.5 mg tablet2.04USD tablet
Capozide 25-15 tablet2.03USD tablet
Capozide 25-25 tablet2.03USD tablet
Accuretic 10-12.5 mg tablet2.0USD tablet
Accuretic 20-25 mg tablet2.0USD tablet
Lotensin HCT 20-12.5 mg tablet1.97USD tablet
Lotensin HCT 10-12.5 mg tablet1.95USD tablet
Lotensin HCT 20-25 mg tablet1.94USD tablet
Lotensin hct 10-12.5 tablet1.9USD tablet
Lotensin hct 20-12.5 tablet1.9USD tablet
Lotensin hct 20-25 tablet1.9USD tablet
Lotensin hct 5-6.25 tablet1.9USD tablet
Niferex-150 150-50-50 mg capsule1.62USD capsule
Capozide 25-15 mg tablet1.51USD tablet
Lotensin HCT 5-6.25 mg tablet1.31USD tablet
Hydrochlorothiazide powder1.1USD g
Hydrochlorothiazide 12.5 mg tablet0.82USD tablet
Moduretic 5-50 mg tablet0.68USD tablet
Hydrochlorothiazide 12.5 mg capsule0.5USD capsule
Hydrochlorothiazide 50 mg tablet0.16USD tablet
Apo-Hydro 100 mg Tablet0.13USD tablet
Hydrochlorothiazide 25 mg tablet0.11USD tablet
Apo-Hydro 50 mg Tablet0.06USD tablet
Novo-Hydrazide 50 mg Tablet0.06USD tablet
Apo-Hydro 25 mg Tablet0.04USD tablet
Novo-Hydrazide 25 mg Tablet0.04USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5559111 No1998-07-212018-07-21Us
US5616599 Yes1996-10-252016-10-25Us
US5994348 Yes1995-12-072015-12-07Us
US6294197 Yes1997-12-182017-12-18Us
US6358986 No2000-01-102020-01-10Us
US6878703 Yes2002-05-192022-05-19Us
US8101599 No2003-05-162023-05-16Us
US8183295 No2003-05-162023-05-16Us
US8475839 Yes2003-11-162023-11-16Us
US8618172 No2008-07-132028-07-13Us
US8618174 No2001-11-152021-11-15Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point266-268U.S. Patent 3,163,645.
water solubility722 mg/L (at 25 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP-0.07HANSCH,C ET AL. (1995)
logS-2.62ADME Research, USCD
Caco2 permeability-6.06ADME Research, USCD
pKa7.9SANGSTER (1994)
Predicted Properties
PropertyValueSource
Water Solubility2.24 mg/mLALOGPS
logP-0.16ALOGPS
logP-0.58ChemAxon
logS-2.1ALOGPS
pKa (Strongest Acidic)9.09ChemAxon
pKa (Strongest Basic)-2.7ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area118.36 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity63.11 m3·mol-1ChemAxon
Polarizability25.35 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (11.5 KB)
Spectra
Spectrum TypeDescriptionSplash Key
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-052b-0090000000-aaa48e4702874457ae26View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-0r6r-0920000000-b129acf72e7dde12441eView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-0a4i-1900000000-67f803f38aed0bd12adeView in MoNA
MSMass Spectrum (Electron Ionization)splash10-00r2-6490000000-3f5d9320308b823c6489View in MoNA
1D NMR1H NMR SpectrumNot Available
1D NMR1H NMR SpectrumNot Available
1D NMR13C NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
References
Synthesis Reference

Frederic J. Nugent, John K. C. Yen, “Process for preparing the combination products of triamterene and hydrochlorothiazide.” U.S. Patent US4804540, issued July, 1987.

US4804540
General ReferencesNot Available
External Links
ATC CodesC03AA03C03AB03C03AX01C03EA01C09DX01C09DX03C09XA52C09XA54
AHFS Codes
  • 40:28.20
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (72.7 KB)
Interactions
Drug Interactions
Drug
AcetohexamideThe therapeutic efficacy of Acetohexamide can be decreased when used in combination with Hydrochlorothiazide.
Acetylsalicylic acidThe risk or severity of adverse effects can be increased when Acetylsalicylic acid is combined with Hydrochlorothiazide.
AldesleukinThe risk or severity of adverse effects can be increased when Aldesleukin is combined with Hydrochlorothiazide.
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Hydrochlorothiazide.
AlfuzosinAlfuzosin may increase the hypotensive activities of Hydrochlorothiazide.
AllopurinolThe risk of a hypersensitivity reaction to Allopurinol is increased when it is combined with Hydrochlorothiazide.
AlogliptinThe therapeutic efficacy of Alogliptin can be decreased when used in combination with Hydrochlorothiazide.
AmifostineHydrochlorothiazide may increase the hypotensive activities of Amifostine.
BenazeprilHydrochlorothiazide may increase the hypotensive activities of Benazepril.
BrimonidineBrimonidine may increase the antihypertensive activities of Hydrochlorothiazide.
BuprenorphineThe risk or severity of adverse effects can be increased when Buprenorphine is combined with Hydrochlorothiazide.
ButabarbitalButabarbital may increase the orthostatic hypotensive activities of Hydrochlorothiazide.
ButethalButethal may increase the orthostatic hypotensive activities of Hydrochlorothiazide.
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Hydrochlorothiazide.
CaffeineThe risk or severity of adverse effects can be increased when Caffeine is combined with Hydrochlorothiazide.
CanagliflozinThe therapeutic efficacy of Canagliflozin can be decreased when used in combination with Hydrochlorothiazide.
CarbamazepineThe risk or severity of adverse effects can be increased when Hydrochlorothiazide is combined with Carbamazepine.
ChlorphenamineThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Hydrochlorothiazide.
ChlorpropamideThe therapeutic efficacy of Chlorpropamide can be decreased when used in combination with Hydrochlorothiazide.
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Hydrochlorothiazide.
ColesevelamColesevelam can cause a decrease in the absorption of Hydrochlorothiazide resulting in a reduced serum concentration and potentially a decrease in efficacy.
CyclophosphamideThe risk or severity of adverse effects can be increased when Hydrochlorothiazide is combined with Cyclophosphamide.
DexketoprofenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Hydrochlorothiazide.
DiazoxideThe risk or severity of adverse effects can be increased when Hydrochlorothiazide is combined with Diazoxide.
DigoxinThe risk or severity of adverse effects can be increased when Hydrochlorothiazide is combined with Digoxin.
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Hydrochlorothiazide.
DihydrotachysterolHydrochlorothiazide may increase the hypercalcemic activities of Dihydrotachysterol.
DofetilideHydrochlorothiazide may increase the QTc-prolonging activities of Dofetilide.
DuloxetineHydrochlorothiazide may increase the orthostatic hypotensive activities of Duloxetine.
EthanolEthanol may increase the orthostatic hypotensive activities of Hydrochlorothiazide.
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Hydrochlorothiazide.
FludrocortisoneFludrocortisone may increase the hypokalemic activities of Hydrochlorothiazide.
FlunisolideFlunisolide may increase the hypokalemic activities of Hydrochlorothiazide.
GliclazideThe therapeutic efficacy of Gliclazide can be decreased when used in combination with Hydrochlorothiazide.
GlimepirideThe therapeutic efficacy of Glimepiride can be decreased when used in combination with Hydrochlorothiazide.
GliquidoneThe therapeutic efficacy of Gliquidone can be decreased when used in combination with Hydrochlorothiazide.
GlyburideThe therapeutic efficacy of Glyburide can be decreased when used in combination with Hydrochlorothiazide.
HeptabarbitalHeptabarbital may increase the orthostatic hypotensive activities of Hydrochlorothiazide.
HexobarbitalHexobarbital may increase the orthostatic hypotensive activities of Hydrochlorothiazide.
HydrocodoneThe risk or severity of adverse effects can be increased when Hydrocodone is combined with Hydrochlorothiazide.
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Hydrochlorothiazide.
InfliximabThe therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Infliximab.
Insulin AspartThe therapeutic efficacy of Insulin Aspart can be decreased when used in combination with Hydrochlorothiazide.
Insulin DetemirThe therapeutic efficacy of Insulin Detemir can be decreased when used in combination with Hydrochlorothiazide.
Insulin GlargineThe therapeutic efficacy of Insulin Glargine can be decreased when used in combination with Hydrochlorothiazide.
Insulin GlulisineThe therapeutic efficacy of Insulin Glulisine can be decreased when used in combination with Hydrochlorothiazide.
Insulin HumanThe therapeutic efficacy of Insulin Regular can be decreased when used in combination with Hydrochlorothiazide.
Insulin LisproThe therapeutic efficacy of Insulin Lispro can be decreased when used in combination with Hydrochlorothiazide.
IvabradineHydrochlorothiazide may increase the arrhythmogenic activities of Ivabradine.
LevodopaHydrochlorothiazide may increase the orthostatic hypotensive activities of Levodopa.
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Hydrochlorothiazide.
LicoriceLicorice may increase the hypokalemic activities of Hydrochlorothiazide.
LinagliptinThe therapeutic efficacy of Linagliptin can be decreased when used in combination with Hydrochlorothiazide.
LithiumHydrochlorothiazide may decrease the excretion rate of Lithium which could result in a lower serum level and potentially a reduction in efficacy.
MecamylamineThe risk or severity of adverse effects can be increased when Hydrochlorothiazide is combined with Mecamylamine.
MetforminThe therapeutic efficacy of Metformin can be decreased when used in combination with Hydrochlorothiazide.
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Hydrochlorothiazide.
MethohexitalMethohexital may increase the orthostatic hypotensive activities of Hydrochlorothiazide.
MethylphenidateMethylphenidate may decrease the antihypertensive activities of Hydrochlorothiazide.
MolsidomineMolsidomine may increase the hypotensive activities of Hydrochlorothiazide.
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Hydrochlorothiazide.
MoxonidineMoxonidine may increase the hypotensive activities of Hydrochlorothiazide.
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Hydrochlorothiazide.
NicorandilNicorandil may increase the hypotensive activities of Hydrochlorothiazide.
ObinutuzumabHydrochlorothiazide may increase the hypotensive activities of Obinutuzumab.
OrciprenalineOrciprenaline may increase the hypokalemic activities of Hydrochlorothiazide.
OxcarbazepineThe risk or severity of adverse effects can be increased when Hydrochlorothiazide is combined with Oxcarbazepine.
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Hydrochlorothiazide.
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Hydrochlorothiazide.
ParoxetineParoxetine may increase the activities of Hydrochlorothiazide.
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Hydrochlorothiazide.
PentobarbitalPentobarbital may increase the orthostatic hypotensive activities of Hydrochlorothiazide.
PentoxifyllinePentoxifylline may increase the hypotensive activities of Hydrochlorothiazide.
PerindoprilHydrochlorothiazide may increase the hypotensive activities of Perindopril.
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Hydrochlorothiazide.
PhenelzinePhenelzine may increase the orthostatic hypotensive activities of Hydrochlorothiazide.
PorfimerHydrochlorothiazide may increase the photosensitizing activities of Porfimer.
PrimidonePrimidone may increase the orthostatic hypotensive activities of Hydrochlorothiazide.
ProcyclidineThe serum concentration of Hydrochlorothiazide can be increased when it is combined with Procyclidine.
QuinineQuinine may increase the hypotensive activities of Hydrochlorothiazide.
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Hydrochlorothiazide.
RepaglinideThe therapeutic efficacy of Repaglinide can be decreased when used in combination with Hydrochlorothiazide.
RisperidoneHydrochlorothiazide may increase the hypotensive activities of Risperidone.
RituximabHydrochlorothiazide may increase the hypotensive activities of Rituximab.
SaxagliptinThe therapeutic efficacy of Saxagliptin can be decreased when used in combination with Hydrochlorothiazide.
SecobarbitalSecobarbital may increase the orthostatic hypotensive activities of Hydrochlorothiazide.
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Hydrochlorothiazide.
SulpirideThe risk or severity of adverse effects can be increased when Hydrochlorothiazide is combined with Sulpiride.
TadalafilTadalafil may increase the antihypertensive activities of Hydrochlorothiazide.
TapentadolThe risk or severity of adverse effects can be increased when Tapentadol is combined with Hydrochlorothiazide.
TolbutamideThe therapeutic efficacy of Tolbutamide can be decreased when used in combination with Hydrochlorothiazide.
TopiramateHydrochlorothiazide may increase the hypokalemic activities of Topiramate.
ToremifeneHydrochlorothiazide may increase the hypercalcemic activities of Toremifene.
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Hydrochlorothiazide.
TranylcypromineTranylcypromine may increase the orthostatic hypotensive activities of Hydrochlorothiazide.
TreprostinilTreprostinil may increase the hypotensive activities of Hydrochlorothiazide.
ValsartanHydrochlorothiazide may increase the hypotensive activities of Valsartan.
VardenafilVardenafil may increase the antihypertensive activities of Hydrochlorothiazide.
VerteporfinHydrochlorothiazide may increase the photosensitizing activities of Verteporfin.
VildagliptinThe therapeutic efficacy of Vildagliptin can be decreased when used in combination with Hydrochlorothiazide.
YohimbineYohimbine may decrease the antihypertensive activities of Hydrochlorothiazide.
Food Interactions
  • Avoid alcohol.
  • Avoid excess salt/sodium unless otherwise instructed by your physician.
  • Avoid natural licorice.
  • Do not take calcium, aluminum, magnesium or Iron supplements within 2 hours of taking this medication.
  • Increase potassium intake; add a banana or orange juice; unless instructed otherwise.
  • Take with food.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Transporter activity
Specific Function:
Key mediator of sodium and chloride reabsorption in this nephron segment, accounting for a significant fraction of renal sodium reabsorption.
Gene Name:
SLC12A3
Uniprot ID:
P55017
Molecular Weight:
113138.04 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. Ran XW, Wang C, Dai F, Jiang JJ, Tong NW, Li XJ, Liang JZ: [A case of Gitelman's syndrome presenting with severe hypocalcaemia and hypokalemic periodic paralysis]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2005 Jul;36(4):583-7. [PubMed:16078592 ]
  3. Turner ST, Schwartz GL, Chapman AB, Boerwinkle E: WNK1 kinase polymorphism and blood pressure response to a thiazide diuretic. Hypertension. 2005 Oct;46(4):758-65. Epub 2005 Sep 19. [PubMed:16172412 ]
  4. Abuladze N, Yanagawa N, Lee I, Jo OD, Newman D, Hwang J, Uyemura K, Pushkin A, Modlin RL, Kurtz I: Peripheral blood mononuclear cells express mutated NCCT mRNA in Gitelman's syndrome: evidence for abnormal thiazide-sensitive NaCl cotransport. J Am Soc Nephrol. 1998 May;9(5):819-26. [PubMed:9596079 ]
  5. Barry EL, Gesek FA, Kaplan MR, Hebert SC, Friedman PA: Expression of the sodium-chloride cotransporter in osteoblast-like cells: effect of thiazide diuretics. Am J Physiol. 1997 Jan;272(1 Pt 1):C109-16. [PubMed:9038817 ]
  6. Kurschat C, Heering P, Grabensee B: [Gitelman's syndrome: an important differential diagnosis of hypokalemia]. Dtsch Med Wochenschr. 2003 May 30;128(22):1225-8. [PubMed:12772080 ]
  7. Monroy A, Plata C, Hebert SC, Gamba G: Characterization of the thiazide-sensitive Na(+)-Cl(-) cotransporter: a new model for ions and diuretics interaction. Am J Physiol Renal Physiol. 2000 Jul;279(1):F161-9. [PubMed:10894798 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Zinc ion binding
Specific Function:
Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea.
Gene Name:
CA1
Uniprot ID:
P00915
Molecular Weight:
28870.0 Da
References
  1. Puscas I, Coltau M, Baican M, Domuta G, Hecht A: Vasodilatory effect of diuretics is dependent on inhibition of vascular smooth muscle carbonic anhydrase by a direct mechanism of action. Drugs Exp Clin Res. 1999;25(6):271-9. [PubMed:10713865 ]
  2. Couloigner V, Loiseau A, Sterkers O, Amiel C, Ferrary E: Effect of locally applied drugs on the endolymphatic sac potential. Laryngoscope. 1998 Apr;108(4 Pt 1):592-8. [PubMed:9546276 ]
  3. Temperini C, Cecchi A, Scozzafava A, Supuran CT: Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference. Bioorg Med Chem. 2009 Feb 1;17(3):1214-21. doi: 10.1016/j.bmc.2008.12.023. Epub 2008 Dec 24. [PubMed:19119014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Zinc ion binding
Specific Function:
Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate ex...
Gene Name:
CA2
Uniprot ID:
P00918
Molecular Weight:
29245.895 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Meyerson LR, Nesta D: [3H]acetazolamide binding to carbonic anhydrase in normal and transformed cells. Biochem Pharmacol. 1991 Mar 15-Apr 1;41(6-7):995-1000. [PubMed:1901209 ]
  4. Schaeffer P, Vigne P, Frelin C, Lazdunski M: Identification and pharmacological properties of binding sites for the atypical thiazide diuretic, indapamide. Eur J Pharmacol. 1990 Jul 17;182(3):503-8. [PubMed:2226620 ]
  5. Temperini C, Cecchi A, Scozzafava A, Supuran CT: Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference. Bioorg Med Chem. 2009 Feb 1;17(3):1214-21. doi: 10.1016/j.bmc.2008.12.023. Epub 2008 Dec 24. [PubMed:19119014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Zinc ion binding
Specific Function:
Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid.
Gene Name:
CA4
Uniprot ID:
P22748
Molecular Weight:
35032.075 Da
References
  1. Puscas I, Coltau M, Baican M, Domuta G, Hecht A: Vasodilatory effect of diuretics is dependent on inhibition of vascular smooth muscle carbonic anhydrase by a direct mechanism of action. Drugs Exp Clin Res. 1999;25(6):271-9. [PubMed:10713865 ]
  2. Temperini C, Cecchi A, Scozzafava A, Supuran CT: Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference. Bioorg Med Chem. 2009 Feb 1;17(3):1214-21. doi: 10.1016/j.bmc.2008.12.023. Epub 2008 Dec 24. [PubMed:19119014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Zinc ion binding
Specific Function:
Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia.
Gene Name:
CA9
Uniprot ID:
Q16790
Molecular Weight:
49697.36 Da
References
  1. Temperini C, Cecchi A, Scozzafava A, Supuran CT: Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference. Bioorg Med Chem. 2009 Feb 1;17(3):1214-21. doi: 10.1016/j.bmc.2008.12.023. Epub 2008 Dec 24. [PubMed:19119014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Zinc ion binding
Specific Function:
Reversible hydration of carbon dioxide.
Gene Name:
CA12
Uniprot ID:
O43570
Molecular Weight:
39450.615 Da
References
  1. Temperini C, Cecchi A, Scozzafava A, Supuran CT: Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference. Bioorg Med Chem. 2009 Feb 1;17(3):1214-21. doi: 10.1016/j.bmc.2008.12.023. Epub 2008 Dec 24. [PubMed:19119014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
other/unknown
General Function:
Voltage-gated potassium channel activity
Specific Function:
Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key ...
Gene Name:
KCNMA1
Uniprot ID:
Q12791
Molecular Weight:
137558.115 Da
References
  1. Tricarico D, Barbieri M, Mele A, Carbonara G, Camerino DC: Carbonic anhydrase inhibitors are specific openers of skeletal muscle BK channel of K+-deficient rats. FASEB J. 2004 Apr;18(6):760-1. Epub 2004 Feb 6. [PubMed:14766795 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-in...
Gene Name:
SLC22A6
Uniprot ID:
Q4U2R8
Molecular Weight:
61815.78 Da
References
  1. Race JE, Grassl SM, Williams WJ, Holtzman EJ: Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). Biochem Biophys Res Commun. 1999 Feb 16;255(2):508-14. [PubMed:10049739 ]
  2. Uwai Y, Saito H, Hashimoto Y, Inui KI: Interaction and transport of thiazide diuretics, loop diuretics, and acetazolamide via rat renal organic anion transporter rOAT1. J Pharmacol Exp Ther. 2000 Oct;295(1):261-5. [PubMed:10991988 ]
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Drug created on June 13, 2005 07:24 / Updated on June 28, 2016 03:06