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Identification
NameDelavirdine
Accession NumberDB00705  (APRD00149, DB08563)
TypeSmall Molecule
GroupsApproved
DescriptionA potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. [PubChem]
Structure
Thumb
Synonyms
(N-[2-[4-[3-(1-Methylethylamino)pyridin-2-yl]piperazin-1-yl]carbonyl-1H-indol-5-yl] methanesulfonamide)
1-(3-((1-Methylethyl)amino)-2-pyridinyl)-4-((5-((methylsulfonyl)amino)-1H-indol-2-yl)carbonyl)piperazine
2-(4-(5-Methanesulfonamido-1H-indol-2-ylcarbonyl)-1-piperazinyl)-N-(1-methylethyl)-3-pyridinamine
Delavirdin
Delavirdina
Delavirdine
Delavirdinum
N-(2-(1-(3-(Isopropylamino)pyridin-2-yl)piperazine-4-carbonyl)-1H-indol-5-yl)methanesulfonamide
N-{2-[4-(3-isopropylamino-pyridin-2-yl)-piperazine-1-carbonyl]-1H-indol-5-yl}-methanesulfonamide
External Identifiers
  • U 90152 S
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Rescriptortablet200 mg/1oralKAISER FOUNDATION HOSPITALS2011-07-06Not applicableUs
Rescriptortablet100 mgoralViiv Healthcare Ulc1998-07-24Not applicableCanada
Rescriptortablet100 mg/1oralVii V Healthcare Company2010-10-13Not applicableUs
Rescriptortablet200 mg/1oralVii V Healthcare Company2010-10-13Not applicableUs
Rescriptortablet200 mg/1oralVii V Healthcare Company2012-04-11Not applicableUs
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Delavirdine mesylate
147221-93-0
Thumb
  • InChI Key: MEPNHSOMXMALDZ-UHFFFAOYSA-N
  • Monoisotopic Mass: 552.182474166
  • Average Mass: 552.667
DBSALT000038
Categories
UNIIDOL5F9JD3E
CAS number136817-59-9
WeightAverage: 456.561
Monoisotopic: 456.194359482
Chemical FormulaC22H28N6O3S
InChI KeyInChIKey=WHBIGIKBNXZKFE-UHFFFAOYSA-N
InChI
InChI=1S/C22H28N6O3S/c1-15(2)24-19-5-4-8-23-21(19)27-9-11-28(12-10-27)22(29)20-14-16-13-17(26-32(3,30)31)6-7-18(16)25-20/h4-8,13-15,24-26H,9-12H2,1-3H3
IUPAC Name
N-[2-(4-{3-[(propan-2-yl)amino]pyridin-2-yl}piperazine-1-carbonyl)-1H-indol-5-yl]methanesulfonamide
SMILES
CC(C)NC1=C(N=CC=C1)N1CCN(CC1)C(=O)C1=CC2=C(N1)C=CC(NS(C)(=O)=O)=C2
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as pyridinylpiperazines. These are compounds containing a pyridinylpiperazine skeleton, which consists of a pyridine linked (not fused) to a piperazine by a bond by a single bond that is not part of a ring.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassDiazinanes
Sub ClassPiperazines
Direct ParentPyridinylpiperazines
Alternative Parents
Substituents
  • N-arylpiperazine
  • Pyridinylpiperazine
  • Indolecarboxylic acid derivative
  • Indolecarboxamide derivative
  • Sulfanilide
  • Indole or derivatives
  • Indole
  • Dialkylarylamine
  • Pyrrole-2-carboxylic acid or derivatives
  • Pyrrole-2-carboxamide
  • Secondary aliphatic/aromatic amine
  • Aminopyridine
  • Imidolactam
  • Benzenoid
  • Substituted pyrrole
  • Pyridine
  • Heteroaromatic compound
  • Aminosulfonyl compound
  • Sulfonyl
  • Sulfonic acid derivative
  • Sulfonamide
  • Pyrrole
  • Tertiary amine
  • Carboxamide group
  • Azacycle
  • Secondary amine
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organosulfur compound
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of HIV-1 infection in combination with appropriate antiretroviral agents when therapy is warranted
PharmacodynamicsDelavirdine is a non-nucleoside reverse transcriptase inhibitor (nNRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Delavirdine binds directly to reverse transcriptase (RT) and blocks the RNA-dependent and DNA-dependent DNA polymerase activities by causing a disruption of the enzyme's catalytic site. The activity of Delavirdine does not compete with template or nucleoside triphosphates. HIV-2 RT and eukaryotic DNA polymerases (such as human DNA polymerases alpha, beta, or sigma) are not inhibited by Delavirdine.
Mechanism of actionDelavirdine binds directly to viral reverse transcriptase (RT) and blocks the RNA-dependent and DNA-dependent DNA polymerase activities by disrupting the enzyme's catalytic site.
Related Articles
AbsorptionRapidly absorbed
Volume of distributionNot Available
Protein binding98%
Metabolism

Hepatic

SubstrateEnzymesProduct
Delavirdine
N-desalkyl delavirdineDetails
Route of eliminationDelavirdine is extensively converted to several inactive metabolites by cytochrome P450 3A (CYP3A). Delavirdine was excreted in the milk of lactating rats at a concentration three to five times that of rat plasma.
Half life5.8 hours
ClearanceNot Available
ToxicityMajor toxicity of delavirdine is rash and should be advised to promptly notify their physician should rash occur. The majority of rashes associated with delavirdine occur within 1 to 3 weeks after initiating treatment with delavirdine. The rash normally resolves in 3 to 14 days and may be treated symptomatically while therapy with delavirdine is continued. Any patient experiencing severe rash or rash accompanied by symptoms such as fever, blistering, oral lesions, conjunctivitis, swelling, muscle or joint aches should discontinue medication and consult a physician.
Affected organisms
  • Human Immunodeficiency Virus
Pathways
PathwayCategorySMPDB ID
Delavirdine Action PathwayDrug actionSMP00738
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier-0.6449
Caco-2 permeable-0.6231
P-glycoprotein substrateSubstrate0.7103
P-glycoprotein inhibitor IInhibitor0.7647
P-glycoprotein inhibitor IINon-inhibitor0.5644
Renal organic cation transporterNon-inhibitor0.7808
CYP450 2C9 substrateNon-substrate0.6717
CYP450 2D6 substrateSubstrate0.8918
CYP450 3A4 substrateSubstrate0.6707
CYP450 1A2 substrateNon-inhibitor0.6644
CYP450 2C9 inhibitorInhibitor0.6307
CYP450 2D6 inhibitorNon-inhibitor0.8556
CYP450 2C19 inhibitorNon-inhibitor0.6078
CYP450 3A4 inhibitorNon-inhibitor0.6383
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.9308
Ames testNon AMES toxic0.6189
CarcinogenicityNon-carcinogens0.7517
BiodegradationNot ready biodegradable0.9891
Rat acute toxicity2.5840 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.7656
hERG inhibition (predictor II)Inhibitor0.6118
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Viiv healthcare co
Packagers
Dosage forms
FormRouteStrength
Tabletoral100 mg
Tabletoral100 mg/1
Tabletoral200 mg/1
Prices
Unit descriptionCostUnit
Rescriptor 200 mg tablet1.92USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2071529 No2001-03-202010-12-24Canada
CA2184598 No2005-05-032015-03-01Canada
US5563142 No1993-10-082013-10-08Us
US6177101 No1999-06-072019-06-07Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point226-228 °CNot Available
logP2.8Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.086 mg/mLALOGPS
logP2.77ALOGPS
logP1.02ChemAxon
logS-3.7ALOGPS
pKa (Strongest Acidic)9.39ChemAxon
pKa (Strongest Basic)6.82ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area110.43 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity126.64 m3·mol-1ChemAxon
Polarizability50.01 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

DrugSyn.org

US5563142
General ReferencesNot Available
External Links
ATC CodesJ05AG02
AHFS Codes
  • 08:18.08.16
PDB EntriesNot Available
FDA labelDownload (645 KB)
MSDSNot Available
Interactions
Drug Interactions
Drug
1,10-PhenanthrolineThe serum concentration of Delavirdine can be decreased when it is combined with 1,10-Phenanthroline.
3,4-DichloroisocoumarinThe serum concentration of Delavirdine can be decreased when it is combined with 3,4-Dichloroisocoumarin.
4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDEThe serum concentration of Delavirdine can be decreased when it is combined with 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE.
4-MethoxyamphetamineThe metabolism of 4-Methoxyamphetamine can be decreased when combined with Delavirdine.
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Delavirdine.
AceclofenacThe metabolism of Aceclofenac can be decreased when combined with Delavirdine.
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Delavirdine.
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Delavirdine.
AcetylcholineThe metabolism of Acetylcholine can be decreased when combined with Delavirdine.
Acetylsalicylic acidThe metabolism of Acetylsalicylic acid can be decreased when combined with Delavirdine.
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Delavirdine.
AjmalineThe metabolism of Ajmaline can be decreased when combined with Delavirdine.
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Delavirdine.
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Delavirdine.
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Delavirdine.
AlfuzosinThe metabolism of Alfuzosin can be decreased when combined with Delavirdine.
AliskirenThe metabolism of Aliskiren can be decreased when combined with Delavirdine.
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Delavirdine.
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Delavirdine.
AlogliptinThe serum concentration of Delavirdine can be decreased when it is combined with Alogliptin.
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Delavirdine.
AlosetronThe metabolism of Alosetron can be decreased when combined with Delavirdine.
Alpha-1-proteinase inhibitorThe serum concentration of Delavirdine can be decreased when it is combined with Alpha-1-proteinase inhibitor.
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Delavirdine.
AlprenololThe metabolism of Alprenolol can be decreased when combined with Delavirdine.
Aluminum hydroxideThe serum concentration of Delavirdine can be decreased when it is combined with Aluminum hydroxide.
Aluminum phosphateThe serum concentration of Delavirdine can be decreased when it is combined with Aluminum phosphate.
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Delavirdine.
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Delavirdine.
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Delavirdine.
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Delavirdine.
AmiodaroneThe metabolism of Amiodarone can be decreased when combined with Delavirdine.
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Delavirdine.
AmlodipineThe metabolism of Amlodipine can be decreased when combined with Delavirdine.
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Delavirdine.
AmoxapineThe metabolism of Amoxapine can be decreased when combined with Delavirdine.
AmoxicillinThe metabolism of Amoxicillin can be decreased when combined with Delavirdine.
AmphetamineThe metabolism of Amphetamine can be decreased when combined with Delavirdine.
AmprenavirThe serum concentration of Delavirdine can be decreased when it is combined with Amprenavir.
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Delavirdine.
AmsacrineThe metabolism of Amsacrine can be decreased when combined with Delavirdine.
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Delavirdine.
Antithrombin III humanThe serum concentration of Delavirdine can be decreased when it is combined with Antithrombin III human.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Delavirdine.
ApixabanThe serum concentration of Delavirdine can be decreased when it is combined with Apixaban.
ApremilastThe metabolism of Apremilast can be decreased when combined with Delavirdine.
AprepitantThe serum concentration of Delavirdine can be increased when it is combined with Aprepitant.
AprepitantThe metabolism of Aprepitant can be decreased when combined with Delavirdine.
AprindineThe metabolism of Aprindine can be decreased when combined with Delavirdine.
AprotininThe serum concentration of Delavirdine can be decreased when it is combined with Aprotinin.
Arachidonic AcidThe metabolism of Arachidonic Acid can be decreased when combined with Delavirdine.
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Delavirdine.
ArgatrobanThe serum concentration of Delavirdine can be decreased when it is combined with Argatroban.
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Delavirdine.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Delavirdine.
ArtemetherThe metabolism of Artemether can be decreased when combined with Delavirdine.
AsenapineThe serum concentration of Delavirdine can be decreased when it is combined with Asenapine.
AsenapineThe metabolism of Asenapine can be decreased when combined with Delavirdine.
AstemizoleDelavirdine may increase the arrhythmogenic activities of Astemizole.
AsunaprevirThe serum concentration of Delavirdine can be decreased when it is combined with Asunaprevir.
AtazanavirThe serum concentration of Delavirdine can be decreased when it is combined with Atazanavir.
AtazanavirThe metabolism of Atazanavir can be decreased when combined with Delavirdine.
AtomoxetineThe serum concentration of Atomoxetine can be increased when it is combined with Delavirdine.
AtomoxetineThe metabolism of Delavirdine can be decreased when combined with Atomoxetine.
AtorvastatinThe metabolism of Atorvastatin can be decreased when combined with Delavirdine.
AvanafilThe metabolism of Avanafil can be decreased when combined with Delavirdine.
AxitinibThe metabolism of Axitinib can be decreased when combined with Delavirdine.
AzelastineThe metabolism of Azelastine can be decreased when combined with Delavirdine.
AzithromycinThe metabolism of Azithromycin can be decreased when combined with Delavirdine.
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Delavirdine.
BatimastatThe serum concentration of Delavirdine can be decreased when it is combined with Batimastat.
BedaquilineThe metabolism of Bedaquiline can be decreased when combined with Delavirdine.
BenazeprilThe serum concentration of Delavirdine can be decreased when it is combined with Benazepril.
BenzamidineThe serum concentration of Delavirdine can be decreased when it is combined with Benzamidine.
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Delavirdine.
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Delavirdine.
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Delavirdine.
BepridilThe metabolism of Bepridil can be decreased when combined with Delavirdine.
BetaxololThe metabolism of Delavirdine can be decreased when combined with Betaxolol.
BexaroteneThe serum concentration of Delavirdine can be decreased when it is combined with Bexarotene.
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Delavirdine.
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Delavirdine.
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Delavirdine.
Bismuth SubcitrateThe serum concentration of Delavirdine can be decreased when it is combined with Bismuth Subcitrate.
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Delavirdine.
BivalirudinThe serum concentration of Delavirdine can be decreased when it is combined with Bivalirudin.
BoceprevirThe serum concentration of Delavirdine can be decreased when it is combined with Boceprevir.
BoceprevirThe metabolism of Boceprevir can be decreased when combined with Delavirdine.
BortezomibThe metabolism of Delavirdine can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Delavirdine can be decreased when it is combined with Bosentan.
BosentanThe serum concentration of Bosentan can be increased when it is combined with Delavirdine.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Delavirdine.
Brentuximab vedotinThe metabolism of Brentuximab vedotin can be decreased when combined with Delavirdine.
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Delavirdine.
BrinzolamideThe metabolism of Brinzolamide can be decreased when combined with Delavirdine.
BromazepamThe metabolism of Bromazepam can be decreased when combined with Delavirdine.
BromocriptineThe metabolism of Bromocriptine can be decreased when combined with Delavirdine.
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Delavirdine.
BudesonideThe metabolism of Budesonide can be decreased when combined with Delavirdine.
BufuralolThe metabolism of Bufuralol can be decreased when combined with Delavirdine.
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Delavirdine.
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Delavirdine.
BupropionThe metabolism of Bupropion can be decreased when combined with Delavirdine.
BuspironeThe metabolism of Buspirone can be decreased when combined with Delavirdine.
BusulfanThe metabolism of Busulfan can be decreased when combined with Delavirdine.
CabazitaxelThe metabolism of Cabazitaxel can be decreased when combined with Delavirdine.
CabergolineThe metabolism of Cabergoline can be decreased when combined with Delavirdine.
CabozantinibThe metabolism of Cabozantinib can be decreased when combined with Delavirdine.
CaffeineThe metabolism of Caffeine can be decreased when combined with Delavirdine.
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Delavirdine.
Calcium carbonateThe serum concentration of Delavirdine can be decreased when it is combined with Calcium carbonate.
CanagliflozinThe metabolism of Canagliflozin can be decreased when combined with Delavirdine.
CandesartanThe metabolism of Candesartan can be decreased when combined with Delavirdine.
CandoxatrilThe serum concentration of Delavirdine can be decreased when it is combined with Candoxatril.
CaptoprilThe serum concentration of Delavirdine can be decreased when it is combined with Captopril.
CaptoprilThe metabolism of Captopril can be decreased when combined with Delavirdine.
CarbamazepineThe metabolism of Delavirdine can be increased when combined with Carbamazepine.
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Delavirdine.
CariprazineThe metabolism of Cariprazine can be decreased when combined with Delavirdine.
CarisoprodolThe metabolism of Carisoprodol can be decreased when combined with Delavirdine.
CarteololThe metabolism of Carteolol can be decreased when combined with Delavirdine.
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Delavirdine.
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Delavirdine.
CeliprololThe metabolism of Celiprolol can be decreased when combined with Delavirdine.
CephalexinThe metabolism of Cephalexin can be decreased when combined with Delavirdine.
CeritinibThe serum concentration of Delavirdine can be increased when it is combined with Ceritinib.
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Delavirdine.
CevimelineThe metabolism of Cevimeline can be decreased when combined with Delavirdine.
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Delavirdine.
ChloramphenicolThe metabolism of Chloramphenicol can be decreased when combined with Delavirdine.
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Delavirdine.
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Delavirdine.
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Delavirdine.
ChlorpromazineThe metabolism of Chlorpromazine can be decreased when combined with Delavirdine.
ChlorpropamideThe metabolism of Chlorpropamide can be decreased when combined with Delavirdine.
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Delavirdine.
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Delavirdine.
ChymostatinThe serum concentration of Delavirdine can be decreased when it is combined with Chymostatin.
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Delavirdine.
CilastatinThe serum concentration of Delavirdine can be decreased when it is combined with Cilastatin.
CilazaprilThe serum concentration of Delavirdine can be decreased when it is combined with Cilazapril.
CilostazolThe metabolism of Cilostazol can be decreased when combined with Delavirdine.
CimetidineThe serum concentration of Delavirdine can be decreased when it is combined with Cimetidine.
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Delavirdine.
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Delavirdine.
CisaprideThe metabolism of Cisapride can be decreased when combined with Delavirdine.
CitalopramThe metabolism of Citalopram can be decreased when combined with Delavirdine.
ClarithromycinThe metabolism of Clarithromycin can be decreased when combined with Delavirdine.
ClemastineThe metabolism of Delavirdine can be decreased when combined with Clemastine.
ClevidipineThe metabolism of Clevidipine can be decreased when combined with Delavirdine.
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Delavirdine.
ClobazamThe metabolism of Clobazam can be decreased when combined with Delavirdine.
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Delavirdine.
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Delavirdine.
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Delavirdine.
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Delavirdine.
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Delavirdine.
ClonidineThe metabolism of Clonidine can be decreased when combined with Delavirdine.
ClopidogrelThe metabolism of Clopidogrel can be decreased when combined with Delavirdine.
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Delavirdine.
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Delavirdine.
ClotrimazoleThe metabolism of Delavirdine can be decreased when combined with Clotrimazole.
ClozapineThe metabolism of Clozapine can be decreased when combined with Delavirdine.
CobicistatThe serum concentration of Delavirdine can be increased when it is combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Delavirdine.
CocaineThe metabolism of Cocaine can be decreased when combined with Delavirdine.
CodeineThe metabolism of Codeine can be decreased when combined with Delavirdine.
ColchicineThe metabolism of Colchicine can be decreased when combined with Delavirdine.
ConivaptanThe serum concentration of Delavirdine can be increased when it is combined with Conivaptan.
ConivaptanThe metabolism of Conivaptan can be decreased when combined with Delavirdine.
Conjugated Equine EstrogensThe metabolism of Conjugated Equine Estrogens can be decreased when combined with Delavirdine.
Cortisone acetateThe metabolism of Cortisone acetate can be decreased when combined with Delavirdine.
CrizotinibThe metabolism of Crizotinib can be decreased when combined with Delavirdine.
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Delavirdine.
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Delavirdine.
CyclosporineThe metabolism of Delavirdine can be decreased when combined with Cyclosporine.
CytarabineThe metabolism of Cytarabine can be decreased when combined with Delavirdine.
Dabigatran etexilateThe serum concentration of Delavirdine can be decreased when it is combined with Dabigatran etexilate.
DabrafenibThe serum concentration of Delavirdine can be decreased when it is combined with Dabrafenib.
DabrafenibThe metabolism of Dabrafenib can be decreased when combined with Delavirdine.
DaclatasvirThe metabolism of Daclatasvir can be decreased when combined with Delavirdine.
DantroleneThe metabolism of Dantrolene can be decreased when combined with Delavirdine.
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Delavirdine.
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Delavirdine.
DapsoneThe metabolism of Dapsone can be decreased when combined with Delavirdine.
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Delavirdine.
DarunavirThe serum concentration of Delavirdine can be increased when it is combined with Darunavir.
DarunavirThe metabolism of Darunavir can be decreased when combined with Delavirdine.
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Delavirdine.
DasatinibThe serum concentration of Delavirdine can be increased when it is combined with Dasatinib.
DasatinibThe metabolism of Dasatinib can be decreased when combined with Delavirdine.
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Delavirdine.
DebrisoquinThe metabolism of Debrisoquin can be decreased when combined with Delavirdine.
DeferasiroxThe serum concentration of Delavirdine can be decreased when it is combined with Deferasirox.
DehydroepiandrosteroneThe metabolism of Dehydroepiandrosterone can be decreased when combined with Delavirdine.
DesipramineThe metabolism of Desipramine can be decreased when combined with Delavirdine.
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Delavirdine.
DexamethasoneThe serum concentration of Delavirdine can be decreased when it is combined with Dexamethasone.
DexamethasoneThe metabolism of Dexamethasone can be decreased when combined with Delavirdine.
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Delavirdine.
DexmethylphenidateThe metabolism of Dexmethylphenidate can be decreased when combined with Delavirdine.
DextroamphetamineThe metabolism of Dextroamphetamine can be decreased when combined with Delavirdine.
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Delavirdine.
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Delavirdine.
DiazepamThe metabolism of Diazepam can be decreased when combined with Delavirdine.
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Delavirdine.
DicoumarolThe metabolism of Dicoumarol can be decreased when combined with Delavirdine.
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Delavirdine.
DigoxinThe metabolism of Digoxin can be decreased when combined with Delavirdine.
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Delavirdine.
DihydroergotamineThe metabolism of Delavirdine can be decreased when combined with Dihydroergotamine.
DiltiazemThe metabolism of Delavirdine can be decreased when combined with Diltiazem.
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Delavirdine.
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Delavirdine.
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Delavirdine.
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Delavirdine.
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Delavirdine.
DolasetronThe metabolism of Dolasetron can be decreased when combined with Delavirdine.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Delavirdine.
DonepezilThe metabolism of Donepezil can be decreased when combined with Delavirdine.
DopamineThe metabolism of Dopamine can be decreased when combined with Delavirdine.
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Delavirdine.
DoxazosinThe metabolism of Doxazosin can be decreased when combined with Delavirdine.
DoxepinThe serum concentration of Delavirdine can be decreased when it is combined with Doxepin.
DoxepinThe metabolism of Doxepin can be decreased when combined with Delavirdine.
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Delavirdine.
DoxycyclineThe metabolism of Delavirdine can be decreased when combined with Doxycycline.
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Delavirdine.
DronedaroneThe metabolism of Dronedarone can be decreased when combined with Delavirdine.
DuloxetineThe serum concentration of Duloxetine can be increased when it is combined with Delavirdine.
DuloxetineThe metabolism of Delavirdine can be decreased when combined with Duloxetine.
DutasterideThe metabolism of Dutasteride can be decreased when combined with Delavirdine.
EcabetThe serum concentration of Delavirdine can be decreased when it is combined with Ecabet.
EdoxabanThe serum concentration of Delavirdine can be decreased when it is combined with Edoxaban.
EfavirenzThe serum concentration of Delavirdine can be decreased when it is combined with Efavirenz.
EfavirenzThe metabolism of Efavirenz can be decreased when combined with Delavirdine.
ElafinThe serum concentration of Delavirdine can be decreased when it is combined with Elafin.
EletriptanThe metabolism of Eletriptan can be decreased when combined with Delavirdine.
EliglustatThe metabolism of Eliglustat can be decreased when combined with Delavirdine.
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Delavirdine.
EnalaprilThe serum concentration of Delavirdine can be decreased when it is combined with Enalapril.
EnalaprilThe metabolism of Enalapril can be decreased when combined with Delavirdine.
EnalaprilatThe serum concentration of Delavirdine can be decreased when it is combined with Enalaprilat.
EnalkirenThe serum concentration of Delavirdine can be decreased when it is combined with Enalkiren.
EncainideThe metabolism of Encainide can be decreased when combined with Delavirdine.
EnclomipheneThe metabolism of Enclomiphene can be decreased when combined with Delavirdine.
EnfuvirtideThe metabolism of Enfuvirtide can be decreased when combined with Delavirdine.
EnzalutamideThe serum concentration of Delavirdine can be decreased when it is combined with Enzalutamide.
EnzalutamideThe metabolism of Enzalutamide can be decreased when combined with Delavirdine.
EpinastineThe serum concentration of Delavirdine can be decreased when it is combined with Epinastine.
EpinastineThe metabolism of Epinastine can be decreased when combined with Delavirdine.
EplerenoneThe metabolism of Eplerenone can be decreased when combined with Delavirdine.
EpoprostenolThe metabolism of Epoprostenol can be decreased when combined with Delavirdine.
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Delavirdine.
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be decreased when combined with Delavirdine.
ErgonovineThe metabolism of Ergonovine can be decreased when combined with Delavirdine.
ErgotamineThe metabolism of Ergotamine can be decreased when combined with Delavirdine.
ErlotinibThe metabolism of Erlotinib can be decreased when combined with Delavirdine.
ErythromycinThe metabolism of Delavirdine can be decreased when combined with Erythromycin.
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Delavirdine.
Eslicarbazepine acetateThe serum concentration of Delavirdine can be decreased when it is combined with Eslicarbazepine acetate.
EsmirtazapineThe metabolism of Esmirtazapine can be decreased when combined with Delavirdine.
EsomeprazoleThe serum concentration of Delavirdine can be decreased when it is combined with Esomeprazole.
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Delavirdine.
EstazolamThe metabolism of Estazolam can be decreased when combined with Delavirdine.
EstradiolThe metabolism of Estradiol can be decreased when combined with Delavirdine.
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Delavirdine.
EstramustineThe metabolism of Estramustine can be decreased when combined with Delavirdine.
EstroneThe metabolism of Estrone can be decreased when combined with Delavirdine.
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Delavirdine.
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Delavirdine.
EthanolThe metabolism of Ethanol can be decreased when combined with Delavirdine.
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be decreased when combined with Delavirdine.
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Delavirdine.
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Delavirdine.
EtodolacThe metabolism of Etodolac can be decreased when combined with Delavirdine.
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Delavirdine.
EtoposideThe metabolism of Etoposide can be decreased when combined with Delavirdine.
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Delavirdine.
EtravirineThe serum concentration of Delavirdine can be decreased when it is combined with Etravirine.
EtravirineThe metabolism of Etravirine can be decreased when combined with Delavirdine.
EverolimusThe metabolism of Everolimus can be decreased when combined with Delavirdine.
ExemestaneThe metabolism of Exemestane can be decreased when combined with Delavirdine.
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Delavirdine.
FamotidineThe serum concentration of Delavirdine can be decreased when it is combined with Famotidine.
FamotidineThe metabolism of Famotidine can be decreased when combined with Delavirdine.
FelbamateThe metabolism of Felbamate can be decreased when combined with Delavirdine.
FelodipineThe metabolism of Felodipine can be decreased when combined with Delavirdine.
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Delavirdine.
FentanylThe metabolism of Fentanyl can be decreased when combined with Delavirdine.
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Delavirdine.
FinasterideThe metabolism of Finasteride can be decreased when combined with Delavirdine.
FingolimodThe metabolism of Fingolimod can be decreased when combined with Delavirdine.
FlecainideThe metabolism of Flecainide can be decreased when combined with Delavirdine.
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Delavirdine.
FluconazoleThe metabolism of Delavirdine can be decreased when combined with Fluconazole.
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Delavirdine.
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Delavirdine.
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Delavirdine.
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Delavirdine.
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Delavirdine.
FluphenazineThe metabolism of Fluphenazine can be decreased when combined with Delavirdine.
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Delavirdine.
FlurbiprofenThe metabolism of Flurbiprofen can be decreased when combined with Delavirdine.
FlutamideThe metabolism of Flutamide can be decreased when combined with Delavirdine.
Fluticasone furoateThe metabolism of Fluticasone furoate can be decreased when combined with Delavirdine.
Fluticasone PropionateThe metabolism of Fluticasone Propionate can be decreased when combined with Delavirdine.
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Delavirdine.
FluvoxamineThe metabolism of Delavirdine can be decreased when combined with Fluvoxamine.
FormoterolThe metabolism of Formoterol can be decreased when combined with Delavirdine.
FosamprenavirThe serum concentration of Delavirdine can be decreased when it is combined with Fosamprenavir.
FosamprenavirThe metabolism of Fosamprenavir can be decreased when combined with Delavirdine.
FosaprepitantThe serum concentration of Delavirdine can be increased when it is combined with Fosaprepitant.
FosinoprilThe serum concentration of Delavirdine can be decreased when it is combined with Fosinopril.
FosphenytoinThe serum concentration of Delavirdine can be decreased when it is combined with Fosphenytoin.
FosphenytoinThe metabolism of Fosphenytoin can be decreased when combined with Delavirdine.
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Delavirdine.
Fusidic AcidThe serum concentration of Delavirdine can be increased when it is combined with Fusidic Acid.
GalantamineThe metabolism of Galantamine can be decreased when combined with Delavirdine.
GavestinelThe metabolism of Gavestinel can be decreased when combined with Delavirdine.
GefitinibThe metabolism of Gefitinib can be decreased when combined with Delavirdine.
GeldanamycinThe serum concentration of Delavirdine can be decreased when it is combined with Geldanamycin.
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Delavirdine.
GliclazideThe metabolism of Gliclazide can be decreased when combined with Delavirdine.
GlimepirideThe metabolism of Glimepiride can be decreased when combined with Delavirdine.
GlipizideThe metabolism of Glipizide can be decreased when combined with Delavirdine.
GlucosamineThe metabolism of Glucosamine can be decreased when combined with Delavirdine.
GlyburideThe metabolism of Glyburide can be decreased when combined with Delavirdine.
GM6001The serum concentration of Delavirdine can be decreased when it is combined with GM6001.
GranisetronThe metabolism of Granisetron can be decreased when combined with Delavirdine.
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Delavirdine.
GuanfacineThe metabolism of Guanfacine can be decreased when combined with Delavirdine.
HalofantrineThe metabolism of Halofantrine can be decreased when combined with Delavirdine.
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Delavirdine.
HalothaneThe metabolism of Halothane can be decreased when combined with Delavirdine.
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Delavirdine.
HirulogThe serum concentration of Delavirdine can be decreased when it is combined with Hirulog.
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Delavirdine.
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Delavirdine.
HydrocortisoneThe metabolism of Hydrocortisone can be decreased when combined with Delavirdine.
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Delavirdine.
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Delavirdine.
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Delavirdine.
IbuprofenThe metabolism of Ibuprofen can be decreased when combined with Delavirdine.
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Delavirdine.
IdelalisibThe serum concentration of Delavirdine can be increased when it is combined with Idelalisib.
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Delavirdine resulting in a loss in efficacy.
IloperidoneThe metabolism of Iloperidone can be decreased when combined with Delavirdine.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Delavirdine.
ImatinibThe metabolism of Delavirdine can be decreased when combined with Imatinib.
ImipramineThe metabolism of Imipramine can be decreased when combined with Delavirdine.
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Delavirdine.
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Delavirdine.
IndapamideThe metabolism of Indapamide can be decreased when combined with Delavirdine.
IndinavirThe metabolism of Indinavir can be decreased when combined with Delavirdine.
indisulamThe metabolism of indisulam can be decreased when combined with Delavirdine.
IndomethacinThe metabolism of Indomethacin can be decreased when combined with Delavirdine.
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Delavirdine.
IrbesartanThe metabolism of Irbesartan can be decreased when combined with Delavirdine.
IrinotecanThe metabolism of Irinotecan can be decreased when combined with Delavirdine.
IsavuconazoniumThe metabolism of Delavirdine can be decreased when combined with Isavuconazonium.
IsoflurophateThe serum concentration of Delavirdine can be decreased when it is combined with Isoflurophate.
IsoniazidThe metabolism of Delavirdine can be decreased when combined with Isoniazid.
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Delavirdine.
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Delavirdine.
IsradipineThe metabolism of Delavirdine can be decreased when combined with Isradipine.
ItraconazoleThe metabolism of Itraconazole can be decreased when combined with Delavirdine.
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Delavirdine.
IvacaftorThe serum concentration of Delavirdine can be increased when it is combined with Ivacaftor.
IvacaftorThe metabolism of Ivacaftor can be decreased when combined with Delavirdine.
IvermectinThe metabolism of Ivermectin can be decreased when combined with Delavirdine.
IxabepiloneThe metabolism of Ixabepilone can be decreased when combined with Delavirdine.
IxazomibThe serum concentration of Delavirdine can be decreased when it is combined with Ixazomib.
IxazomibThe metabolism of Ixazomib can be decreased when combined with Delavirdine.
KetamineThe metabolism of Ketamine can be decreased when combined with Delavirdine.
KetazolamThe metabolism of Ketazolam can be decreased when combined with Delavirdine.
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Delavirdine.
KetoconazoleThe metabolism of Ketoconazole can be decreased when combined with Delavirdine.
KetoprofenThe metabolism of Ketoprofen can be decreased when combined with Delavirdine.
LabetalolThe metabolism of Labetalol can be decreased when combined with Delavirdine.
LacosamideThe serum concentration of Lacosamide can be increased when it is combined with Delavirdine.
LansoprazoleThe serum concentration of Delavirdine can be decreased when it is combined with Lansoprazole.
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Delavirdine.
LapatinibThe metabolism of Lapatinib can be decreased when combined with Delavirdine.
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Delavirdine.
LeflunomideThe metabolism of Leflunomide can be decreased when combined with Delavirdine.
LenvatinibThe metabolism of Lenvatinib can be decreased when combined with Delavirdine.
LepirudinThe serum concentration of Delavirdine can be decreased when it is combined with Lepirudin.
LercanidipineThe metabolism of Lercanidipine can be decreased when combined with Delavirdine.
LesinuradThe metabolism of Lesinurad can be decreased when combined with Delavirdine.
LetrozoleThe metabolism of Letrozole can be decreased when combined with Delavirdine.
LevobupivacaineThe metabolism of Levobupivacaine can be decreased when combined with Delavirdine.
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Delavirdine.
LevodopaThe metabolism of Levodopa can be decreased when combined with Delavirdine.
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Delavirdine.
LevomilnacipranThe metabolism of Levomilnacipran can be decreased when combined with Delavirdine.
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Delavirdine.
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Delavirdine.
LicofeloneThe metabolism of Licofelone can be decreased when combined with Delavirdine.
LidocaineThe metabolism of Lidocaine can be decreased when combined with Delavirdine.
LinagliptinThe serum concentration of Delavirdine can be decreased when it is combined with Linagliptin.
LisinoprilThe serum concentration of Delavirdine can be decreased when it is combined with Lisinopril.
LisurideThe metabolism of Lisuride can be decreased when combined with Delavirdine.
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Delavirdine.
LomustineThe metabolism of Lomustine can be decreased when combined with Delavirdine.
LoperamideThe metabolism of Loperamide can be decreased when combined with Delavirdine.
LopinavirThe serum concentration of Delavirdine can be decreased when it is combined with Lopinavir.
LopinavirThe metabolism of Lopinavir can be decreased when combined with Delavirdine.
LoratadineThe metabolism of Loratadine can be decreased when combined with Delavirdine.
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Delavirdine.
LornoxicamThe metabolism of Lornoxicam can be decreased when combined with Delavirdine.
LosartanThe metabolism of Losartan can be decreased when combined with Delavirdine.
LovastatinThe metabolism of Delavirdine can be decreased when combined with Lovastatin.
LuliconazoleThe serum concentration of Delavirdine can be increased when it is combined with Luliconazole.
LumefantrineThe metabolism of Lumefantrine can be decreased when combined with Delavirdine.
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Delavirdine.
LurasidoneThe metabolism of Lurasidone can be decreased when combined with Delavirdine.
MacitentanThe metabolism of Macitentan can be decreased when combined with Delavirdine.
MagaldrateThe serum concentration of Delavirdine can be decreased when it is combined with Magaldrate.
Magnesium carbonateThe serum concentration of Delavirdine can be decreased when it is combined with Magnesium carbonate.
Magnesium hydroxideThe serum concentration of Delavirdine can be decreased when it is combined with Magnesium hydroxide.
Magnesium oxideThe serum concentration of Delavirdine can be decreased when it is combined with Magnesium oxide.
Magnesium TrisilicateThe serum concentration of Delavirdine can be decreased when it is combined with Magnesium Trisilicate.
MaprotilineThe metabolism of Maprotiline can be decreased when combined with Delavirdine.
MaravirocThe metabolism of Maraviroc can be decreased when combined with Delavirdine.
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Delavirdine.
Medroxyprogesterone acetateThe metabolism of Medroxyprogesterone acetate can be decreased when combined with Delavirdine.
Mefenamic acidThe metabolism of Mefenamic acid can be decreased when combined with Delavirdine.
MefloquineThe metabolism of Mefloquine can be decreased when combined with Delavirdine.
MelatoninThe metabolism of Melatonin can be decreased when combined with Delavirdine.
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Delavirdine.
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Delavirdine.
MeprobamateThe metabolism of Meprobamate can be decreased when combined with Delavirdine.
MequitazineThe serum concentration of Mequitazine can be increased when it is combined with Delavirdine.
MesoridazineThe metabolism of Mesoridazine can be decreased when combined with Delavirdine.
MestranolThe metabolism of Mestranol can be decreased when combined with Delavirdine.
MethadoneThe metabolism of Methadone can be decreased when combined with Delavirdine.
MethamphetamineThe metabolism of Methamphetamine can be decreased when combined with Delavirdine.
MethanthelineThe serum concentration of Delavirdine can be decreased when it is combined with Methantheline.
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Delavirdine.
MethotrimeprazineThe metabolism of Methotrimeprazine can be decreased when combined with Delavirdine.
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Delavirdine.
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Delavirdine.
MethsuximideThe metabolism of Methsuximide can be decreased when combined with Delavirdine.
MethylphenidateThe metabolism of Methylphenidate can be decreased when combined with Delavirdine.
MethylphenobarbitalThe metabolism of Methylphenobarbital can be decreased when combined with Delavirdine.
MethylprednisoloneThe metabolism of Methylprednisolone can be decreased when combined with Delavirdine.
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Delavirdine.
MethyprylonThe metabolism of Methyprylon can be decreased when combined with Delavirdine.
MetiamideThe serum concentration of Delavirdine can be decreased when it is combined with Metiamide.
MetoclopramideThe metabolism of Metoclopramide can be decreased when combined with Delavirdine.
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Delavirdine.
MetoprololThe metabolism of Delavirdine can be decreased when combined with Metoprolol.
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Delavirdine.
MexiletineThe metabolism of Mexiletine can be decreased when combined with Delavirdine.
MianserinThe metabolism of Mianserin can be decreased when combined with Delavirdine.
MibefradilThe metabolism of Mibefradil can be decreased when combined with Delavirdine.
MiconazoleThe metabolism of Miconazole can be decreased when combined with Delavirdine.
MidazolamThe metabolism of Midazolam can be decreased when combined with Delavirdine.
MifepristoneThe metabolism of Mifepristone can be decreased when combined with Delavirdine.
MinaprineThe metabolism of Minaprine can be decreased when combined with Delavirdine.
MirabegronThe metabolism of Mirabegron can be decreased when combined with Delavirdine.
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Delavirdine.
MitotaneThe serum concentration of Delavirdine can be decreased when it is combined with Mitotane.
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Delavirdine.
ModafinilThe serum concentration of Delavirdine can be decreased when it is combined with Modafinil.
ModafinilThe metabolism of Modafinil can be decreased when combined with Delavirdine.
MoexiprilThe serum concentration of Delavirdine can be decreased when it is combined with Moexipril.
MontelukastThe metabolism of Montelukast can be decreased when combined with Delavirdine.
MorphineThe metabolism of Morphine can be decreased when combined with Delavirdine.
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Delavirdine.
N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-ProlineThe serum concentration of Delavirdine can be decreased when it is combined with N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline.
NafcillinThe serum concentration of Delavirdine can be decreased when it is combined with Nafcillin.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Delavirdine.
NaloxoneThe metabolism of Naloxone can be decreased when combined with Delavirdine.
NaproxenThe metabolism of Naproxen can be decreased when combined with Delavirdine.
NateglinideThe metabolism of Nateglinide can be decreased when combined with Delavirdine.
NCX 4016The serum concentration of Delavirdine can be decreased when it is combined with NCX 4016.
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Delavirdine.
NefazodoneThe metabolism of Nefazodone can be decreased when combined with Delavirdine.
NelfinavirThe serum concentration of Delavirdine can be decreased when it is combined with Nelfinavir.
NelfinavirThe metabolism of Nelfinavir can be decreased when combined with Delavirdine.
NetupitantThe serum concentration of Delavirdine can be increased when it is combined with Netupitant.
NetupitantThe metabolism of Netupitant can be decreased when combined with Delavirdine.
NevirapineThe metabolism of Delavirdine can be decreased when combined with Nevirapine.
NicardipineThe metabolism of Nicardipine can be decreased when combined with Delavirdine.
NicergolineThe metabolism of Nicergoline can be decreased when combined with Delavirdine.
NiclosamideThe metabolism of Niclosamide can be decreased when combined with Delavirdine.
NicotineThe metabolism of Nicotine can be decreased when combined with Delavirdine.
NifedipineThe metabolism of Nifedipine can be decreased when combined with Delavirdine.
NilotinibThe metabolism of Nilotinib can be decreased when combined with Delavirdine.
NilutamideThe metabolism of Nilutamide can be decreased when combined with Delavirdine.
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Delavirdine.
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Delavirdine.
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Delavirdine.
NisoldipineThe metabolism of Nisoldipine can be decreased when combined with Delavirdine.
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Delavirdine.
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Delavirdine.
NitrofuralThe metabolism of Nitrofural can be decreased when combined with Delavirdine.
NizatidineThe serum concentration of Delavirdine can be decreased when it is combined with Nizatidine.
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Delavirdine.
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Delavirdine.
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Delavirdine.
OlanzapineThe serum concentration of Delavirdine can be decreased when it is combined with Olanzapine.
OlanzapineThe metabolism of Olanzapine can be decreased when combined with Delavirdine.
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Delavirdine.
OlaparibThe metabolism of Delavirdine can be decreased when combined with Olaparib.
OlodaterolThe metabolism of Olodaterol can be decreased when combined with Delavirdine.
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Delavirdine.
OmapatrilatThe serum concentration of Delavirdine can be decreased when it is combined with Omapatrilat.
OmeprazoleThe serum concentration of Delavirdine can be decreased when it is combined with Omeprazole.
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Delavirdine.
OndansetronThe metabolism of Ondansetron can be decreased when combined with Delavirdine.
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Delavirdine.
OsimertinibThe serum concentration of Delavirdine can be increased when it is combined with Osimertinib.
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Delavirdine.
OtamixabanThe serum concentration of Delavirdine can be decreased when it is combined with Otamixaban.
OxaprozinThe metabolism of Oxaprozin can be decreased when combined with Delavirdine.
OxazepamThe metabolism of Oxazepam can be decreased when combined with Delavirdine.
OxiconazoleThe metabolism of Oxiconazole can be decreased when combined with Delavirdine.
OxybutyninThe metabolism of Oxybutynin can be decreased when combined with Delavirdine.
OxycodoneThe metabolism of Oxycodone can be decreased when combined with Delavirdine.
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Delavirdine.
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Delavirdine.
PalbociclibThe serum concentration of Delavirdine can be increased when it is combined with Palbociclib.
PalbociclibThe metabolism of Palbociclib can be decreased when combined with Delavirdine.
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Delavirdine.
PanobinostatThe metabolism of Panobinostat can be decreased when combined with Delavirdine.
PantoprazoleThe serum concentration of Delavirdine can be decreased when it is combined with Pantoprazole.
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Delavirdine.
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Delavirdine.
ParamethasoneThe metabolism of Paramethasone can be decreased when combined with Delavirdine.
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Delavirdine.
ParicalcitolThe metabolism of Paricalcitol can be decreased when combined with Delavirdine.
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Delavirdine.
ParoxetineThe metabolism of Paroxetine can be decreased when combined with Delavirdine.
PazopanibThe metabolism of Pazopanib can be decreased when combined with Delavirdine.
Peginterferon alfa-2bThe serum concentration of Delavirdine can be decreased when it is combined with Peginterferon alfa-2b.
PentamidineThe metabolism of Pentamidine can be decreased when combined with Delavirdine.
PentobarbitalThe metabolism of Delavirdine can be increased when combined with Pentobarbital.
PerampanelThe metabolism of Perampanel can be decreased when combined with Delavirdine.
PergolideThe metabolism of Pergolide can be decreased when combined with Delavirdine.
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Delavirdine.
PerindoprilThe serum concentration of Delavirdine can be decreased when it is combined with Perindopril.
PermethrinThe metabolism of Permethrin can be decreased when combined with Delavirdine.
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Delavirdine.
PethidineThe metabolism of Pethidine can be decreased when combined with Delavirdine.
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Delavirdine.
PhenforminThe metabolism of Phenformin can be decreased when combined with Delavirdine.
PhenobarbitalThe metabolism of Delavirdine can be increased when combined with Phenobarbital.
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Delavirdine.
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Delavirdine.
PhenylbutazoneThe metabolism of Phenylbutazone can be decreased when combined with Delavirdine.
PhenytoinThe serum concentration of Delavirdine can be decreased when it is combined with Phenytoin.
PhenytoinThe metabolism of Phenytoin can be decreased when combined with Delavirdine.
PhosphoramidonThe serum concentration of Delavirdine can be decreased when it is combined with Phosphoramidon.
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Delavirdine.
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Delavirdine.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Delavirdine.
PinacidilThe metabolism of Pinacidil can be decreased when combined with Delavirdine.
PindololThe metabolism of Pindolol can be decreased when combined with Delavirdine.
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Delavirdine.
PiperazineThe metabolism of Piperazine can be decreased when combined with Delavirdine.
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Delavirdine.
PiroxicamThe metabolism of Piroxicam can be decreased when combined with Delavirdine.
PitavastatinThe metabolism of Pitavastatin can be decreased when combined with Delavirdine.
PodofiloxThe metabolism of Podofilox can be decreased when combined with Delavirdine.
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Delavirdine.
PonatinibThe metabolism of Ponatinib can be decreased when combined with Delavirdine.
PosaconazoleThe metabolism of Posaconazole can be decreased when combined with Delavirdine.
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Delavirdine.
PravastatinThe metabolism of Pravastatin can be decreased when combined with Delavirdine.
PrazepamThe metabolism of Prazepam can be decreased when combined with Delavirdine.
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Delavirdine.
PrednisoloneThe metabolism of Prednisolone can be decreased when combined with Delavirdine.
PrednisoneThe metabolism of Prednisone can be decreased when combined with Delavirdine.
PrimaquineThe metabolism of Primaquine can be decreased when combined with Delavirdine.
PrimidoneThe metabolism of Delavirdine can be increased when combined with Primidone.
PrinomastatThe serum concentration of Delavirdine can be decreased when it is combined with Prinomastat.
ProcainamideThe metabolism of Procainamide can be decreased when combined with Delavirdine.
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Delavirdine.
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Delavirdine.
ProguanilThe metabolism of Proguanil can be decreased when combined with Delavirdine.
PromazineThe metabolism of Promazine can be decreased when combined with Delavirdine.
PromethazineThe metabolism of Promethazine can be decreased when combined with Delavirdine.
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Delavirdine.
PropofolThe metabolism of Propofol can be decreased when combined with Delavirdine.
PropranololThe metabolism of Propranolol can be decreased when combined with Delavirdine.
ProtriptylineThe metabolism of Protriptyline can be decreased when combined with Delavirdine.
PseudoephedrineThe metabolism of Pseudoephedrine can be decreased when combined with Delavirdine.
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Delavirdine.
QuazepamThe metabolism of Quazepam can be decreased when combined with Delavirdine.
QuetiapineThe metabolism of Quetiapine can be decreased when combined with Delavirdine.
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Delavirdine.
QuinaprilThe serum concentration of Delavirdine can be decreased when it is combined with Quinapril.
QuinidineThe metabolism of Quinidine can be decreased when combined with Delavirdine.
QuinineThe metabolism of Quinine can be decreased when combined with Delavirdine.
RabeprazoleThe serum concentration of Delavirdine can be decreased when it is combined with Rabeprazole.
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Delavirdine.
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Delavirdine.
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Delavirdine.
RamiprilThe serum concentration of Delavirdine can be decreased when it is combined with Ramipril.
RanitidineThe serum concentration of Delavirdine can be decreased when it is combined with Ranitidine.
RanitidineThe metabolism of Ranitidine can be decreased when combined with Delavirdine.
RanolazineThe metabolism of Delavirdine can be decreased when combined with Ranolazine.
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Delavirdine.
RegorafenibThe metabolism of Regorafenib can be decreased when combined with Delavirdine.
RemikirenThe serum concentration of Delavirdine can be decreased when it is combined with Remikiren.
RemoxiprideThe metabolism of Remoxipride can be decreased when combined with Delavirdine.
RepaglinideThe metabolism of Repaglinide can be decreased when combined with Delavirdine.
repinotanThe metabolism of repinotan can be decreased when combined with Delavirdine.
RetapamulinThe metabolism of Retapamulin can be decreased when combined with Delavirdine.
RifabutinThe metabolism of Delavirdine can be increased when combined with Rifabutin.
RifampicinThe metabolism of Delavirdine can be increased when combined with Rifampicin.
RifapentineThe metabolism of Delavirdine can be increased when combined with Rifapentine.
RilpivirineThe metabolism of Rilpivirine can be decreased when combined with Delavirdine.
RimonabantThe metabolism of Rimonabant can be decreased when combined with Delavirdine.
RiociguatThe metabolism of Riociguat can be decreased when combined with Delavirdine.
RisperidoneThe metabolism of Risperidone can be decreased when combined with Delavirdine.
RitonavirThe serum concentration of Delavirdine can be decreased when it is combined with Ritonavir.
RitonavirThe metabolism of Ritonavir can be decreased when combined with Delavirdine.
RivaroxabanThe serum concentration of Delavirdine can be decreased when it is combined with Rivaroxaban.
RivaroxabanThe metabolism of Rivaroxaban can be decreased when combined with Delavirdine.
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Delavirdine.
RolapitantThe metabolism of Rolapitant can be decreased when combined with Delavirdine.
RomidepsinThe metabolism of Romidepsin can be decreased when combined with Delavirdine.
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Delavirdine.
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Delavirdine.
RosiglitazoneThe metabolism of Rosiglitazone can be decreased when combined with Delavirdine.
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Delavirdine.
RotigotineThe metabolism of Rotigotine can be decreased when combined with Delavirdine.
Roxatidine acetateThe serum concentration of Delavirdine can be decreased when it is combined with Roxatidine acetate.
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Delavirdine.
RuxolitinibThe metabolism of Ruxolitinib can be decreased when combined with Delavirdine.
Salicylic acidThe metabolism of Salicylic acid can be decreased when combined with Delavirdine.
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Delavirdine.
SaquinavirThe serum concentration of Delavirdine can be decreased when it is combined with Saquinavir.
SaquinavirThe metabolism of Saquinavir can be decreased when combined with Delavirdine.
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Delavirdine.
SaxagliptinThe serum concentration of Delavirdine can be decreased when it is combined with Saxagliptin.
SelegilineThe metabolism of Selegiline can be decreased when combined with Delavirdine.
SelexipagThe metabolism of Selexipag can be decreased when combined with Delavirdine.
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Delavirdine.
SertindoleThe metabolism of Sertindole can be decreased when combined with Delavirdine.
SertralineThe metabolism of Sertraline can be decreased when combined with Delavirdine.
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Delavirdine.
SibutramineThe metabolism of Sibutramine can be decreased when combined with Delavirdine.
SildenafilThe metabolism of Delavirdine can be decreased when combined with Sildenafil.
SilodosinThe metabolism of Silodosin can be decreased when combined with Delavirdine.
SiltuximabThe serum concentration of Delavirdine can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Delavirdine can be increased when it is combined with Simeprevir.
SimvastatinThe metabolism of Simvastatin can be decreased when combined with Delavirdine.
SirolimusThe metabolism of Sirolimus can be decreased when combined with Delavirdine.
SitagliptinThe serum concentration of Delavirdine can be decreased when it is combined with Sitagliptin.
SitagliptinThe metabolism of Sitagliptin can be decreased when combined with Delavirdine.
SitaxentanThe metabolism of Sitaxentan can be decreased when combined with Delavirdine.
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Delavirdine.
SonidegibThe metabolism of Sonidegib can be decreased when combined with Delavirdine.
SorafenibThe metabolism of Sorafenib can be decreased when combined with Delavirdine.
SparteineThe metabolism of Sparteine can be decreased when combined with Delavirdine.
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Delavirdine.
SpiraprilThe serum concentration of Delavirdine can be decreased when it is combined with Spirapril.
St. John's WortThe serum concentration of Delavirdine can be decreased when it is combined with St. John's Wort.
StiripentolThe serum concentration of Delavirdine can be increased when it is combined with Stiripentol.
SufentanilThe metabolism of Sufentanil can be decreased when combined with Delavirdine.
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Delavirdine.
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Delavirdine.
SulfamoxoleThe metabolism of Sulfamoxole can be decreased when combined with Delavirdine.
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Delavirdine.
SulfisoxazoleThe metabolism of Delavirdine can be decreased when combined with Sulfisoxazole.
SunitinibThe metabolism of Sunitinib can be decreased when combined with Delavirdine.
SuprofenThe metabolism of Suprofen can be decreased when combined with Delavirdine.
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Delavirdine.
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Delavirdine.
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Delavirdine.
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Delavirdine.
TadalafilThe metabolism of Tadalafil can be decreased when combined with Delavirdine.
TAK-390MRThe serum concentration of Delavirdine can be decreased when it is combined with TAK-390MR.
TamoxifenThe serum concentration of the active metabolites of Tamoxifen can be reduced when Tamoxifen is used in combination with Delavirdine resulting in a loss in efficacy.
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Delavirdine.
TapentadolThe metabolism of Tapentadol can be decreased when combined with Delavirdine.
TasosartanThe metabolism of Tasosartan can be decreased when combined with Delavirdine.
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Delavirdine.
TegaserodThe metabolism of Tegaserod can be decreased when combined with Delavirdine.
TelaprevirThe serum concentration of Delavirdine can be decreased when it is combined with Telaprevir.
TelaprevirThe metabolism of Telaprevir can be decreased when combined with Delavirdine.
TelithromycinThe metabolism of Telithromycin can be decreased when combined with Delavirdine.
TemazepamThe metabolism of Temazepam can be decreased when combined with Delavirdine.
TemocaprilThe serum concentration of Delavirdine can be decreased when it is combined with Temocapril.
TemsirolimusThe metabolism of Temsirolimus can be decreased when combined with Delavirdine.
TeniposideThe metabolism of Teniposide can be decreased when combined with Delavirdine.
TenoxicamThe metabolism of Tenoxicam can be decreased when combined with Delavirdine.
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Delavirdine.
TerfenadineDelavirdine may increase the arrhythmogenic activities of Terfenadine.
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Delavirdine.
TestosteroneThe metabolism of Testosterone can be decreased when combined with Delavirdine.
TetrabenazineThe serum concentration of Tetrabenazine can be increased when it is combined with Delavirdine.
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Delavirdine.
ThalidomideThe metabolism of Thalidomide can be decreased when combined with Delavirdine.
TheophyllineThe metabolism of Theophylline can be decreased when combined with Delavirdine.
ThiamylalThe metabolism of Thiamylal can be decreased when combined with Delavirdine.
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Delavirdine.
ThioridazineThe metabolism of Delavirdine can be decreased when combined with Thioridazine.
ThiorphanThe serum concentration of Delavirdine can be decreased when it is combined with Thiorphan.
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Delavirdine.
TiagabineThe metabolism of Tiagabine can be decreased when combined with Delavirdine.
TicagrelorThe metabolism of Ticagrelor can be decreased when combined with Delavirdine.
TiclopidineThe metabolism of Delavirdine can be decreased when combined with Ticlopidine.
TimololThe metabolism of Timolol can be decreased when combined with Delavirdine.
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Delavirdine.
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Delavirdine.
TipranavirThe serum concentration of Delavirdine can be decreased when it is combined with Tipranavir.
TipranavirThe metabolism of Tipranavir can be decreased when combined with Delavirdine.
TocilizumabThe serum concentration of Delavirdine can be decreased when it is combined with Tocilizumab.
TofacitinibThe metabolism of Tofacitinib can be decreased when combined with Delavirdine.
TolbutamideThe metabolism of Tolbutamide can be decreased when combined with Delavirdine.
TolterodineThe metabolism of Tolterodine can be decreased when combined with Delavirdine.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Delavirdine.
TorasemideThe metabolism of Torasemide can be decreased when combined with Delavirdine.
ToremifeneThe metabolism of Toremifene can be decreased when combined with Delavirdine.
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Delavirdine.
TramadolThe therapeutic efficacy of Tramadol can be decreased when used in combination with Delavirdine.
TrandolaprilThe serum concentration of Delavirdine can be decreased when it is combined with Trandolapril.
TranylcypromineThe metabolism of Delavirdine can be decreased when combined with Tranylcypromine.
Trastuzumab emtansineThe metabolism of Trastuzumab emtansine can be decreased when combined with Delavirdine.
TrazodoneThe metabolism of Trazodone can be decreased when combined with Delavirdine.
TreprostinilThe metabolism of Treprostinil can be decreased when combined with Delavirdine.
TretinoinThe metabolism of Tretinoin can be decreased when combined with Delavirdine.
TriamcinoloneThe metabolism of Triamcinolone can be decreased when combined with Delavirdine.
TriazolamThe metabolism of Triazolam can be decreased when combined with Delavirdine.
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Delavirdine.
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Delavirdine.
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Delavirdine.
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Delavirdine.
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Delavirdine.
UbenimexThe serum concentration of Delavirdine can be decreased when it is combined with Ubenimex.
UdenafilThe metabolism of Udenafil can be decreased when combined with Delavirdine.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Delavirdine.
UmeclidiniumThe metabolism of Umeclidinium can be decreased when combined with Delavirdine.
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Delavirdine.
Valproic AcidThe metabolism of Valproic Acid can be decreased when combined with Delavirdine.
ValsartanThe metabolism of Valsartan can be decreased when combined with Delavirdine.
VandetanibThe metabolism of Vandetanib can be decreased when combined with Delavirdine.
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Delavirdine.
VardenafilThe metabolism of Vardenafil can be decreased when combined with Delavirdine.
VemurafenibThe metabolism of Vemurafenib can be decreased when combined with Delavirdine.
VenlafaxineThe metabolism of Delavirdine can be decreased when combined with Venlafaxine.
VerapamilThe metabolism of Delavirdine can be decreased when combined with Verapamil.
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Delavirdine.
VilanterolThe metabolism of Vilanterol can be decreased when combined with Delavirdine.
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Delavirdine.
VildagliptinThe serum concentration of Delavirdine can be decreased when it is combined with Vildagliptin.
VinblastineThe metabolism of Vinblastine can be decreased when combined with Delavirdine.
VincristineThe metabolism of Vincristine can be decreased when combined with Delavirdine.
VindesineThe serum concentration of Vindesine can be increased when it is combined with Delavirdine.
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Delavirdine.
VismodegibThe metabolism of Vismodegib can be decreased when combined with Delavirdine.
VoriconazoleThe metabolism of Voriconazole can be decreased when combined with Delavirdine.
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Delavirdine.
WarfarinThe metabolism of Warfarin can be decreased when combined with Delavirdine.
XimelagatranThe serum concentration of Delavirdine can be decreased when it is combined with Ximelagatran.
XimelagatranThe metabolism of Ximelagatran can be decreased when combined with Delavirdine.
YohimbineThe metabolism of Yohimbine can be decreased when combined with Delavirdine.
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Delavirdine.
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Delavirdine.
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Delavirdine.
ZaltoprofenThe metabolism of Zaltoprofen can be decreased when combined with Delavirdine.
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Delavirdine.
ZileutonThe metabolism of Zileuton can be decreased when combined with Delavirdine.
ZiprasidoneThe metabolism of Delavirdine can be decreased when combined with Ziprasidone.
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Delavirdine.
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Delavirdine.
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Delavirdine.
ZopicloneThe metabolism of Zopiclone can be decreased when combined with Delavirdine.
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Delavirdine.
Food Interactions
  • Take without regard to meals.

Targets

Kind
Protein
Organism
Human immunodeficiency virus 1
Pharmacological action
yes
Actions
inhibitor
General Function:
Rna-dna hybrid ribonuclease activity
Specific Function:
Not Available
Gene Name:
pol
Uniprot ID:
Q72547
Molecular Weight:
65223.615 Da
References
  1. Geitmann M, Unge T, Danielson UH: Biosensor-based kinetic characterization of the interaction between HIV-1 reverse transcriptase and non-nucleoside inhibitors. J Med Chem. 2006 Apr 20;49(8):2367-74. [PubMed:16610780 ]
  2. Xia Q, Radzio J, Anderson KS, Sluis-Cremer N: Probing nonnucleoside inhibitor-induced active-site distortion in HIV-1 reverse transcriptase by transient kinetic analyses. Protein Sci. 2007 Aug;16(8):1728-37. [PubMed:17656585 ]
  3. Freimuth WW: Delavirdine mesylate, a potent non-nucleoside HIV-1 reverse transcriptase inhibitor. Adv Exp Med Biol. 1996;394:279-89. [PubMed:8815692 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Voorman RL, Maio SM, Payne NA, Zhao Z, Koeplinger KA, Wang X: Microsomal metabolism of delavirdine: evidence for mechanism-based inactivation of human cytochrome P450 3A. J Pharmacol Exp Ther. 1998 Oct;287(1):381-8. [PubMed:9765359 ]
  4. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
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Drug created on June 13, 2005 07:24 / Updated on September 26, 2016 02:12