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Identification
NameModafinil
Accession NumberDB00745  (APRD00534)
TypeSmall Molecule
GroupsApproved, Investigational
DescriptionModafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron activation is associated with psychoactivation and euphoria. The exact mechanism of action is unclear, although in vitro studies have shown it to inhibit the reuptake of dopamine by binding to the dopamine reuptake pump, and lead to an increase in extracellular dopamine. Modafinil activates glutamatergic circuits while inhibiting GABA.
Structure
Thumb
Synonyms
Modafinil
Modafinilo
Modafinilum
Moderateafinil
Provigil
External Identifiers
  • CEP 1538
  • CRL 40476
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Alertectablet100 mgoralTeva Canada Limited1999-03-24Not applicableCanada
Auro-modafiniltablet100 mgoralAuro Pharma Inc2014-10-24Not applicableCanada
Bio-modafiniltablet100 mgoralBiomed Pharma2015-10-06Not applicableCanada
Ipg-modafiniltablet100 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Mar-modafiniltablet100 mgoralMarcan Pharmaceuticals Inc2015-01-09Not applicableCanada
Modafiniltablet100 mg/1oralCima Labs Inc.2012-03-29Not applicableUs
Modafiniltablet200 mg/1oralAphena Pharma Solutions Tennessee, Llc2012-03-29Not applicableUs
Modafiniltablet200 mg/1oralCima Labs Inc.2012-03-29Not applicableUs
Modafiniltablet100 mg/1oralPar Pharmaceutical2012-04-06Not applicableUs
Modafiniltablet200 mg/1oralDispensing Solutions, Inc.2012-03-29Not applicableUs
Modafiniltablet200 mg/1oralPar Pharmaceutical2012-04-06Not applicableUs
Modafiniltablet200 mg/1oralSTAT Rx USA LLC2012-04-06Not applicableUs
Provigiltablet200 mg/1oralUnit Dose Services1998-12-24Not applicableUs
Provigiltablet100 mg/1oralRebel Distributors Corp2005-06-03Not applicableUs
Provigiltablet200 mg/1oralbryant ranch prepack1998-12-24Not applicableUs
Provigiltablet100 mg/1oralPhysicians Total Care, Inc.2005-06-03Not applicableUs
Provigiltablet200 mg/1oralRebel Distributors Corp2004-01-19Not applicableUs
Provigiltablet100 mg/1oralbryant ranch prepack1998-12-24Not applicableUs
Provigiltablet200 mg/1oralPhysicians Total Care, Inc.2004-01-19Not applicableUs
Provigiltablet200 mg/1oralLake Erie Medical Surgical & Supply DBA Quality Care Products LLC2011-07-20Not applicableUs
Provigiltablet100 mg/1oralCephalon, Incorporated1999-02-15Not applicableUs
Provigiltablet100 mg/1oralCardinal Health1998-12-24Not applicableUs
Provigiltablet200 mg/1oralCephalon, Incorporated1999-02-15Not applicableUs
Teva-modafiniltablet100 mgoralTeva Canada Limited2014-07-02Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-modafiniltablet100 mgoralApotex Inc2008-05-01Not applicableCanada
Modafiniltablet200 mg/1oralMajor Pharmaceuticals2013-04-03Not applicableUs
Modafiniltablet200 mg/1oralGolden State Medical Supply, Inc.2014-02-03Not applicableUs
Modafiniltablet100 mg/1oralMylan Pharmaceuticals Inc.2012-08-10Not applicableUs
Modafiniltablet100 mg/1oralMylan Institutional Inc.2012-09-06Not applicableUs
Modafiniltablet100 mg/1oralAurobindo Pharma Limited2012-09-27Not applicableUs
Modafiniltablet200 mg/1oralAv Kare, Inc.2014-02-24Not applicableUs
Modafiniltablet200 mg/1oralHikma Pharmaceutical2008-04-04Not applicableUs
Modafiniltablet100 mg/1oralQualitest Pharmaceuticals2013-01-29Not applicableUs
Modafiniltablet100 mg/1oralOrchid Pharma Inc2013-08-01Not applicableUs
Modafiniltablet100 mg/1oralApotex Corp.2014-02-03Not applicableUs
Modafiniltablet200 mg/1oralMylan Pharmaceuticals Inc.2012-08-10Not applicableUs
Modafiniltablet200 mg/1oralMylan Institutional Inc.2012-09-06Not applicableUs
Modafiniltablet200 mg/1oralAurobindo Pharma Limited2012-09-27Not applicableUs
Modafiniltablet200 mg/1oralAphena Pharma Solutions Tennessee, Llc2012-08-10Not applicableUs
Modafiniltablet100 mg/1oralHikma Pharmaceutical2008-04-04Not applicableUs
Modafiniltablet200 mg/1oralQualitest Pharmaceuticals2013-01-29Not applicableUs
Modafiniltablet200 mg/1oralOrchid Pharma Inc2013-08-01Not applicableUs
Modafiniltablet200 mg/1oralApotex Corp.2014-02-03Not applicableUs
Modafiniltablet100 mg/1oralActavis Pharma, Inc.2013-04-03Not applicableUs
Modafiniltablet100 mg/1oralCitron Pharma LLC2012-09-27Not applicableUs
Modafiniltablet100 mg/1oralAmerican Health Packaging2014-04-01Not applicableUs
Modafiniltablet100 mg/1oralIngenus Pharmaceuticals, LLC2014-04-01Not applicableUs
Modafiniltablet100 mg/1oralGolden State Medical Supply, Inc.2014-02-03Not applicableUs
Modafiniltablet100 mg/1oralMajor Pharmaceuticals2013-04-03Not applicableUs
Modafiniltablet200 mg/1oralbryant ranch prepack2013-04-03Not applicableUs
Modafiniltablet100 mg/1oralAv Kare, Inc.2014-02-24Not applicableUs
Modafiniltablet200 mg/1oralCitron Pharma LLC2012-09-27Not applicableUs
Modafiniltablet200 mg/1oralActavis Pharma, Inc.2013-04-03Not applicableUs
Modafiniltablet200 mg/1oralAmerican Health Packaging2014-04-01Not applicableUs
Modafiniltablet200 mg/1oralIngenus Pharmaceuticals, LLC2014-04-01Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
AlertexSaval
AspendosMedochemie
ForcilinLKM
MentixRoyal Pharma
ModasomilCephalon
ModavigilCSL
ModiodalCephalon
ProvakeRanbaxy
ResotylDrugtech
SparlonCephalon
StavigileLibbs
VigicerBeta
VigilCephalon
ZaluxNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNIIR3UK8X3U3D
CAS number68693-11-8
WeightAverage: 273.35
Monoisotopic: 273.082349419
Chemical FormulaC15H15NO2S
InChI KeyInChIKey=YFGHCGITMMYXAQ-UHFFFAOYSA-N
InChI
InChI=1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)
IUPAC Name
2-diphenylmethanesulfinylacetamide
SMILES
NC(=O)CS(=O)C(C1=CC=CC=C1)C1=CC=CC=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassDiphenylmethanes
Direct ParentDiphenylmethanes
Alternative Parents
Substituents
  • Diphenylmethane
  • Sulfoxide
  • Primary carboxylic acid amide
  • Carboxamide group
  • Sulfinyl compound
  • Carboxylic acid derivative
  • Carboxylic acid amide
  • Hydrocarbon derivative
  • Organosulfur compound
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationTo improve wakefulness in patients with excessive daytime sleepiness (EDS) associated with narcolepsy.
PharmacodynamicsModafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron activation is associated with psychoactivation and euphoria. Modafinil is not indicated for complaints of lack of energy or fatigue; but it appears to be very helpful for some patients. Also, it has been used in the treatment of hypersomnia, a disorder in which patients lack the capacity for meaningful sleep and may require ten or more hours per day. Recent studies have have found that modafinil may help recovering cocaine addicts fight their addiction.
Mechanism of actionThe exact mechanism of action is unclear, although in vitro studies have shown it to inhibit the reuptake of dopamine by binding to the dopamine reuptake pump, and lead to an increase in extracellular dopamine. Modafinil activates glutamatergic circuits while inhibiting GABA. Modafinil is thought to have less potential for abuse than other stimulants due to the absence of any significant euphoric or pleasurable effects. It is possible that modafinil acts by a synergistic combination of mechanisms including direct inhibition of dopamine reuptake, indirect inhibition of noradrenalin reuptake in the VLPO and orexin activation. Modafinil has partial alpha 1B-adrenergic agonist effects by directly stimulating the receptors.
Related Articles
AbsorptionRapid following oral administration.
Volume of distribution
  • 0.9 L/kg
Protein binding60%
Metabolism

Hepatic

SubstrateEnzymesProduct
Modafinil
modafinil acidDetails
Route of eliminationThe major route of elimination is metabolism (~90%), primarily by the liver, with subsequent renal elimination of the metabolites.
Half life23-215 hours
ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated Effects
Interacting Gene/EnzymeSNP RS IDAllele nameDefining changeEffectReference(s)
Catechol O-methyltransferase
Gene symbol: COMT
UniProt: P21964
rs4680 Not AvailableAA allelePoor response to modafinil19037200
Catechol O-methyltransferase
Gene symbol: COMT
UniProt: P21964
rs4680 Not AvailableGG alleleThose with the GG genotype respond better to drug therapy (improved vigor and well being). Those with the AA genotype do not respond well to drug therapy19037200
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier+0.9947
Caco-2 permeable+0.5066
P-glycoprotein substrateNon-substrate0.8912
P-glycoprotein inhibitor INon-inhibitor0.8842
P-glycoprotein inhibitor IINon-inhibitor0.9962
Renal organic cation transporterNon-inhibitor0.8153
CYP450 2C9 substrateNon-substrate0.793
CYP450 2D6 substrateNon-substrate0.8659
CYP450 3A4 substrateNon-substrate0.5971
CYP450 1A2 substrateNon-inhibitor0.6653
CYP450 2C9 inhibitorNon-inhibitor0.6045
CYP450 2D6 inhibitorNon-inhibitor0.9117
CYP450 2C19 inhibitorNon-inhibitor0.6952
CYP450 3A4 inhibitorNon-inhibitor0.8309
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.6395
Ames testNon AMES toxic0.6562
CarcinogenicityNon-carcinogens0.6665
BiodegradationReady biodegradable0.6304
Rat acute toxicity2.0926 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9799
hERG inhibition (predictor II)Non-inhibitor0.9279
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Cephalon inc
  • Cephalon, Inc.
Packagers
Dosage forms
FormRouteStrength
Tabletoral100 mg
Tabletoral100 mg/1
Tabletoral200 mg/1
Prices
Unit descriptionCostUnit
Provigil 200 mg tablet15.33USD tablet
Provigil 100 mg tablet13.58USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2165824 No2005-08-022014-06-14Canada
CA2201967 No2002-12-102015-10-04Canada
US7297346 Yes2004-05-292024-05-29Us
USRE37516 No1994-10-062014-10-06Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point164-166 °CNot Available
water solubilitySlightly solubleNot Available
logP0.6Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.622 mg/mLALOGPS
logP1.75ALOGPS
logP1.53ChemAxon
logS-2.6ALOGPS
pKa (Strongest Acidic)8.84ChemAxon
pKa (Strongest Basic)-4.4ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area60.16 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity77.39 m3·mol-1ChemAxon
Polarizability28.71 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

DrugSyn.org

US4177290
General References
  1. Lindsay SE, Gudelsky GA, Heaton PC: Use of modafinil for the treatment of attention deficit/hyperactivity disorder. Ann Pharmacother. 2006 Oct;40(10):1829-33. Epub 2006 Sep 5. [PubMed:16954326 ]
  2. Ishizuka T, Sakamoto Y, Sakurai T, Yamatodani A: Modafinil increases histamine release in the anterior hypothalamus of rats. Neurosci Lett. 2003 Mar 20;339(2):143-6. [PubMed:12614915 ]
External Links
ATC CodesN06BA07
AHFS Codes
  • 28:20.92
PDB EntriesNot Available
FDA labelDownload (98.9 KB)
MSDSDownload (57 KB)
Interactions
Drug Interactions
Drug
AbirateroneThe serum concentration of Abiraterone can be decreased when it is combined with Modafinil.
AcenocoumarolThe serum concentration of Acenocoumarol can be decreased when it is combined with Modafinil.
AcetaminophenThe serum concentration of Acetaminophen can be decreased when it is combined with Modafinil.
AdinazolamThe serum concentration of Adinazolam can be decreased when it is combined with Modafinil.
AlbendazoleThe serum concentration of Albendazole can be decreased when it is combined with Modafinil.
AlclometasoneThe serum concentration of Alclometasone can be decreased when it is combined with Modafinil.
AlfentanilThe serum concentration of Alfentanil can be decreased when it is combined with Modafinil.
AlfuzosinThe serum concentration of Alfuzosin can be decreased when it is combined with Modafinil.
AliskirenThe serum concentration of Aliskiren can be decreased when it is combined with Modafinil.
AllylestrenolThe serum concentration of Allylestrenol can be decreased when it is combined with Modafinil.
AlmotriptanThe serum concentration of Almotriptan can be decreased when it is combined with Modafinil.
AlogliptinThe serum concentration of Alogliptin can be decreased when it is combined with Modafinil.
AlosetronThe serum concentration of Alosetron can be decreased when it is combined with Modafinil.
AlprazolamThe serum concentration of Alprazolam can be decreased when it is combined with Modafinil.
AmbrisentanThe serum concentration of Ambrisentan can be decreased when it is combined with Modafinil.
AmbroxolThe serum concentration of Ambroxol can be decreased when it is combined with Modafinil.
AminophenazoneThe serum concentration of Aminophenazone can be decreased when it is combined with Modafinil.
AminophyllineThe serum concentration of Aminophylline can be decreased when it is combined with Modafinil.
AmiodaroneThe serum concentration of Amiodarone can be decreased when it is combined with Modafinil.
AmiodaroneThe metabolism of Modafinil can be decreased when combined with Amiodarone.
AmitriptylineThe serum concentration of Amitriptyline can be decreased when it is combined with Modafinil.
AmlodipineThe serum concentration of Amlodipine can be decreased when it is combined with Modafinil.
AmoxicillinThe metabolism of Amoxicillin can be decreased when combined with Modafinil.
AmprenavirThe serum concentration of Amprenavir can be decreased when it is combined with Modafinil.
AntipyrineThe serum concentration of Antipyrine can be decreased when it is combined with Modafinil.
ApixabanThe serum concentration of Apixaban can be decreased when it is combined with Modafinil.
ApremilastThe serum concentration of Apremilast can be decreased when it is combined with Modafinil.
AprepitantThe serum concentration of Modafinil can be increased when it is combined with Aprepitant.
AprepitantThe serum concentration of Aprepitant can be decreased when it is combined with Modafinil.
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Modafinil.
ArgatrobanThe serum concentration of Argatroban can be decreased when it is combined with Modafinil.
AripiprazoleThe serum concentration of Aripiprazole can be decreased when it is combined with Modafinil.
ArtemetherThe serum concentration of Artemether can be decreased when it is combined with Modafinil.
AsenapineThe serum concentration of Asenapine can be decreased when it is combined with Modafinil.
AstemizoleThe serum concentration of Astemizole can be decreased when it is combined with Modafinil.
AtazanavirThe serum concentration of Atazanavir can be decreased when it is combined with Modafinil.
AtazanavirThe metabolism of Modafinil can be decreased when combined with Atazanavir.
AtomoxetineThe metabolism of Modafinil can be decreased when combined with Atomoxetine.
AtorvastatinThe serum concentration of Atorvastatin can be decreased when it is combined with Modafinil.
AvanafilThe serum concentration of Avanafil can be decreased when it is combined with Modafinil.
AxitinibThe serum concentration of Axitinib can be decreased when it is combined with Modafinil.
AzelastineThe serum concentration of Azelastine can be decreased when it is combined with Modafinil.
AzithromycinThe serum concentration of Azithromycin can be decreased when it is combined with Modafinil.
BanoxantroneThe serum concentration of Banoxantrone can be decreased when it is combined with Modafinil.
BedaquilineThe serum concentration of Bedaquiline can be decreased when it is combined with Modafinil.
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Modafinil.
BenzphetamineThe serum concentration of Benzphetamine can be decreased when it is combined with Modafinil.
Benzyl alcoholThe serum concentration of Benzyl alcohol can be decreased when it is combined with Modafinil.
BexaroteneThe serum concentration of Modafinil can be decreased when it is combined with Bexarotene.
BezafibrateThe serum concentration of Bezafibrate can be decreased when it is combined with Modafinil.
BicalutamideThe serum concentration of Bicalutamide can be decreased when it is combined with Modafinil.
BisoprololThe serum concentration of Bisoprolol can be decreased when it is combined with Modafinil.
BoceprevirThe serum concentration of Boceprevir can be decreased when it is combined with Modafinil.
BoceprevirThe metabolism of Modafinil can be decreased when combined with Boceprevir.
BortezomibThe serum concentration of Bortezomib can be decreased when it is combined with Modafinil.
BortezomibThe metabolism of Modafinil can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Modafinil can be decreased when it is combined with Bosentan.
BosutinibThe serum concentration of Bosutinib can be decreased when it is combined with Modafinil.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be decreased when it is combined with Modafinil.
BrexpiprazoleThe serum concentration of Brexpiprazole can be decreased when it is combined with Modafinil.
BrinzolamideThe serum concentration of Brinzolamide can be decreased when it is combined with Modafinil.
BromazepamThe serum concentration of Bromazepam can be decreased when it is combined with Modafinil.
BromocriptineThe serum concentration of Bromocriptine can be decreased when it is combined with Modafinil.
BrompheniramineThe serum concentration of Brompheniramine can be decreased when it is combined with Modafinil.
BudesonideThe serum concentration of Budesonide can be decreased when it is combined with Modafinil.
BupivacaineThe serum concentration of Bupivacaine can be decreased when it is combined with Modafinil.
BuprenorphineThe serum concentration of Buprenorphine can be decreased when it is combined with Modafinil.
BupropionThe serum concentration of Bupropion can be decreased when it is combined with Modafinil.
BuspironeThe serum concentration of Buspirone can be decreased when it is combined with Modafinil.
BusulfanThe serum concentration of Busulfan can be decreased when it is combined with Modafinil.
CabazitaxelThe serum concentration of Cabazitaxel can be decreased when it is combined with Modafinil.
CabergolineThe serum concentration of Cabergoline can be decreased when it is combined with Modafinil.
CabozantinibThe serum concentration of Cabozantinib can be decreased when it is combined with Modafinil.
CaffeineThe serum concentration of Caffeine can be decreased when it is combined with Modafinil.
CalcitriolThe serum concentration of Calcitriol can be decreased when it is combined with Modafinil.
CanagliflozinThe serum concentration of Canagliflozin can be decreased when it is combined with Modafinil.
CarbamazepineThe serum concentration of Carbamazepine can be decreased when it is combined with Modafinil.
CarbamazepineThe metabolism of Modafinil can be increased when combined with Carbamazepine.
CarbinoxamineThe serum concentration of Carbinoxamine can be decreased when it is combined with Modafinil.
CariprazineThe serum concentration of Cariprazine can be decreased when it is combined with Modafinil.
CarisoprodolThe metabolism of Carisoprodol can be decreased when combined with Modafinil.
CarvedilolThe serum concentration of Carvedilol can be decreased when it is combined with Modafinil.
CelecoxibThe serum concentration of Celecoxib can be decreased when it is combined with Modafinil.
CeliprololThe serum concentration of Celiprolol can be decreased when it is combined with Modafinil.
CephalexinThe serum concentration of Cephalexin can be decreased when it is combined with Modafinil.
CeritinibThe serum concentration of Modafinil can be increased when it is combined with Ceritinib.
CerivastatinThe serum concentration of Cerivastatin can be decreased when it is combined with Modafinil.
CevimelineThe serum concentration of Cevimeline can be decreased when it is combined with Modafinil.
Chenodeoxycholic acidThe serum concentration of Chenodeoxycholic acid can be decreased when it is combined with Modafinil.
ChloramphenicolThe metabolism of Chloramphenicol can be decreased when combined with Modafinil.
ChlordiazepoxideThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Modafinil.
ChloroquineThe serum concentration of Chloroquine can be decreased when it is combined with Modafinil.
ChlorphenamineThe serum concentration of Chlorphenamine can be decreased when it is combined with Modafinil.
ChlorpromazineThe serum concentration of Chlorpromazine can be decreased when it is combined with Modafinil.
ChlorpropamideThe metabolism of Chlorpropamide can be decreased when combined with Modafinil.
ChlorzoxazoneThe serum concentration of Chlorzoxazone can be decreased when it is combined with Modafinil.
CholecalciferolThe serum concentration of Cholecalciferol can be decreased when it is combined with Modafinil.
CiclesonideThe serum concentration of Ciclesonide can be decreased when it is combined with Modafinil.
CilostazolThe serum concentration of Cilostazol can be decreased when it is combined with Modafinil.
CinacalcetThe serum concentration of Cinacalcet can be decreased when it is combined with Modafinil.
CisaprideThe serum concentration of Cisapride can be decreased when it is combined with Modafinil.
CitalopramThe serum concentration of Citalopram can be decreased when it is combined with Modafinil.
ClarithromycinThe serum concentration of Clarithromycin can be decreased when it is combined with Modafinil.
ClarithromycinThe metabolism of Modafinil can be decreased when combined with Clarithromycin.
ClemastineThe metabolism of Modafinil can be decreased when combined with Clemastine.
ClindamycinThe serum concentration of Clindamycin can be decreased when it is combined with Modafinil.
ClobazamThe serum concentration of Clobazam can be decreased when it is combined with Modafinil.
ClofazimineThe serum concentration of Clofazimine can be decreased when it is combined with Modafinil.
ClofibrateThe serum concentration of Clofibrate can be decreased when it is combined with Modafinil.
clomethiazoleThe serum concentration of clomethiazole can be decreased when it is combined with Modafinil.
ClomipramineThe serum concentration of Clomipramine can be decreased when it is combined with Modafinil.
ClonazepamThe serum concentration of Clonazepam can be decreased when it is combined with Modafinil.
ClonidineThe serum concentration of Clonidine can be decreased when it is combined with Modafinil.
ClopidogrelThe serum concentration of Clopidogrel can be decreased when it is combined with Modafinil.
ClorazepateThe serum concentration of Clorazepate can be decreased when it is combined with Modafinil.
ClotiazepamThe serum concentration of Clotiazepam can be decreased when it is combined with Modafinil.
ClotrimazoleThe metabolism of Modafinil can be decreased when combined with Clotrimazole.
ClozapineThe serum concentration of Clozapine can be decreased when it is combined with Modafinil.
CobicistatThe metabolism of Modafinil can be decreased when combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be decreased when it is combined with Modafinil.
CocaineThe serum concentration of Cocaine can be decreased when it is combined with Modafinil.
CodeineThe serum concentration of Codeine can be decreased when it is combined with Modafinil.
ColchicineThe serum concentration of Colchicine can be decreased when it is combined with Modafinil.
ConivaptanThe serum concentration of Modafinil can be increased when it is combined with Conivaptan.
ConivaptanThe serum concentration of Conivaptan can be decreased when it is combined with Modafinil.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be decreased when it is combined with Modafinil.
Cortisone acetateThe serum concentration of Cortisone acetate can be decreased when it is combined with Modafinil.
CrizotinibThe serum concentration of Crizotinib can be decreased when it is combined with Modafinil.
CrizotinibThe metabolism of Modafinil can be decreased when combined with Crizotinib.
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be decreased when it is combined with Modafinil.
CyclophosphamideThe serum concentration of Cyclophosphamide can be decreased when it is combined with Modafinil.
CyclosporineThe serum concentration of Cyclosporine can be decreased when it is combined with Modafinil.
CyclosporineThe metabolism of Modafinil can be decreased when combined with Cyclosporine.
CytarabineThe serum concentration of Cytarabine can be decreased when it is combined with Modafinil.
DabrafenibThe serum concentration of Dabrafenib can be decreased when it is combined with Modafinil.
DaclatasvirThe serum concentration of Daclatasvir can be decreased when it is combined with Modafinil.
DantroleneThe serum concentration of Dantrolene can be decreased when it is combined with Modafinil.
DapagliflozinThe serum concentration of Dapagliflozin can be decreased when it is combined with Modafinil.
DapsoneThe serum concentration of Dapsone can be decreased when it is combined with Modafinil.
DarifenacinThe serum concentration of Darifenacin can be decreased when it is combined with Modafinil.
DarunavirThe serum concentration of Darunavir can be decreased when it is combined with Modafinil.
DarunavirThe metabolism of Modafinil can be decreased when combined with Darunavir.
DasabuvirThe serum concentration of Dasabuvir can be decreased when it is combined with Modafinil.
DasatinibThe serum concentration of Modafinil can be increased when it is combined with Dasatinib.
DasatinibThe serum concentration of Dasatinib can be decreased when it is combined with Modafinil.
DaunorubicinThe serum concentration of Daunorubicin can be decreased when it is combined with Modafinil.
DeferasiroxThe serum concentration of Modafinil can be decreased when it is combined with Deferasirox.
DehydroepiandrosteroneThe serum concentration of Dehydroepiandrosterone can be decreased when it is combined with Modafinil.
DelavirdineThe serum concentration of Delavirdine can be decreased when it is combined with Modafinil.
DelavirdineThe metabolism of Modafinil can be decreased when combined with Delavirdine.
DesipramineThe metabolism of Desipramine can be decreased when combined with Modafinil.
DesvenlafaxineThe serum concentration of Desvenlafaxine can be decreased when it is combined with Modafinil.
DexamethasoneThe serum concentration of Dexamethasone can be decreased when it is combined with Modafinil.
DextromethorphanThe serum concentration of Dextromethorphan can be decreased when it is combined with Modafinil.
DextropropoxypheneThe serum concentration of Dextropropoxyphene can be decreased when it is combined with Modafinil.
DiazepamThe serum concentration of Diazepam can be decreased when it is combined with Modafinil.
DiclofenacThe serum concentration of Diclofenac can be decreased when it is combined with Modafinil.
DigitoxinThe serum concentration of Digitoxin can be decreased when it is combined with Modafinil.
DigoxinThe serum concentration of Digoxin can be decreased when it is combined with Modafinil.
DihydrocodeineThe serum concentration of Dihydrocodeine can be decreased when it is combined with Modafinil.
DihydroergotamineThe serum concentration of Dihydroergotamine can be decreased when it is combined with Modafinil.
DihydroergotamineThe metabolism of Modafinil can be decreased when combined with Dihydroergotamine.
DiltiazemThe serum concentration of Diltiazem can be decreased when it is combined with Modafinil.
DiltiazemThe metabolism of Modafinil can be decreased when combined with Diltiazem.
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Modafinil.
DisopyramideThe serum concentration of Disopyramide can be decreased when it is combined with Modafinil.
DisulfiramThe serum concentration of Disulfiram can be decreased when it is combined with Modafinil.
DocetaxelThe serum concentration of Docetaxel can be decreased when it is combined with Modafinil.
DofetilideThe serum concentration of Dofetilide can be decreased when it is combined with Modafinil.
DolasetronThe serum concentration of Dolasetron can be decreased when it is combined with Modafinil.
DomperidoneThe serum concentration of Domperidone can be decreased when it is combined with Modafinil.
DonepezilThe serum concentration of Donepezil can be decreased when it is combined with Modafinil.
DopamineThe metabolism of Dopamine can be decreased when combined with Modafinil.
DorzolamideThe serum concentration of Dorzolamide can be decreased when it is combined with Modafinil.
DoxazosinThe metabolism of Doxazosin can be decreased when combined with Modafinil.
DoxepinThe serum concentration of Doxepin can be decreased when it is combined with Modafinil.
DoxorubicinThe serum concentration of Doxorubicin can be decreased when it is combined with Modafinil.
DoxycyclineThe metabolism of Modafinil can be decreased when combined with Doxycycline.
DronabinolThe serum concentration of Dronabinol can be decreased when it is combined with Modafinil.
DronedaroneThe serum concentration of Dronedarone can be decreased when it is combined with Modafinil.
DronedaroneThe metabolism of Modafinil can be decreased when combined with Dronedarone.
DutasterideThe serum concentration of Dutasteride can be decreased when it is combined with Modafinil.
EfavirenzThe serum concentration of Modafinil can be decreased when it is combined with Efavirenz.
EletriptanThe serum concentration of Eletriptan can be decreased when it is combined with Modafinil.
EliglustatThe serum concentration of Eliglustat can be decreased when it is combined with Modafinil.
ElvitegravirThe serum concentration of Elvitegravir can be decreased when it is combined with Modafinil.
EnalaprilThe serum concentration of Enalapril can be decreased when it is combined with Modafinil.
EnfuvirtideThe metabolism of Enfuvirtide can be decreased when combined with Modafinil.
EnzalutamideThe serum concentration of Enzalutamide can be decreased when it is combined with Modafinil.
EpinastineThe serum concentration of Epinastine can be decreased when it is combined with Modafinil.
EplerenoneThe serum concentration of Eplerenone can be decreased when it is combined with Modafinil.
ErgocalciferolThe serum concentration of Ergocalciferol can be decreased when it is combined with Modafinil.
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be decreased when it is combined with Modafinil.
ErgonovineThe serum concentration of Ergonovine can be decreased when it is combined with Modafinil.
ErgotamineThe serum concentration of Ergotamine can be decreased when it is combined with Modafinil.
ErlotinibThe serum concentration of Erlotinib can be decreased when it is combined with Modafinil.
ErythromycinThe serum concentration of Erythromycin can be decreased when it is combined with Modafinil.
ErythromycinThe metabolism of Modafinil can be decreased when combined with Erythromycin.
EscitalopramThe serum concentration of Escitalopram can be decreased when it is combined with Modafinil.
Eslicarbazepine acetateThe serum concentration of Modafinil can be decreased when it is combined with Eslicarbazepine acetate.
EsomeprazoleThe serum concentration of Esomeprazole can be decreased when it is combined with Modafinil.
EstazolamThe serum concentration of Estazolam can be decreased when it is combined with Modafinil.
EstradiolThe serum concentration of Estradiol can be decreased when it is combined with Modafinil.
Estradiol valerate/DienogestThe serum concentration of Estradiol valerate/Dienogest can be decreased when it is combined with Modafinil.
EstramustineThe serum concentration of Estramustine can be decreased when it is combined with Modafinil.
EstroneThe serum concentration of Estrone can be decreased when it is combined with Modafinil.
Estrone sulfateThe serum concentration of Estrone sulfate can be decreased when it is combined with Modafinil.
EszopicloneThe serum concentration of Eszopiclone can be decreased when it is combined with Modafinil.
EthanolThe serum concentration of Ethanol can be decreased when it is combined with Modafinil.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Modafinil.
EthosuximideThe serum concentration of Ethosuximide can be decreased when it is combined with Modafinil.
EthylmorphineThe serum concentration of Ethylmorphine can be decreased when it is combined with Modafinil.
EtonogestrelThe serum concentration of Etonogestrel can be decreased when it is combined with Modafinil.
EtoposideThe serum concentration of Etoposide can be decreased when it is combined with Modafinil.
EtoricoxibThe serum concentration of Etoricoxib can be decreased when it is combined with Modafinil.
EtravirineThe serum concentration of Etravirine can be decreased when it is combined with Modafinil.
EverolimusThe serum concentration of Everolimus can be decreased when it is combined with Modafinil.
ExemestaneThe serum concentration of Exemestane can be decreased when it is combined with Modafinil.
FamciclovirThe serum concentration of Famciclovir can be decreased when it is combined with Modafinil.
FamotidineThe metabolism of Famotidine can be decreased when combined with Modafinil.
FelbamateThe serum concentration of Felbamate can be decreased when it is combined with Modafinil.
FelodipineThe serum concentration of Felodipine can be decreased when it is combined with Modafinil.
FenofibrateThe serum concentration of Fenofibrate can be decreased when it is combined with Modafinil.
FentanylThe serum concentration of Fentanyl can be decreased when it is combined with Modafinil.
FesoterodineThe serum concentration of Fesoterodine can be decreased when it is combined with Modafinil.
FinasterideThe serum concentration of Finasteride can be decreased when it is combined with Modafinil.
FingolimodThe serum concentration of Fingolimod can be decreased when it is combined with Modafinil.
FlibanserinThe serum concentration of Flibanserin can be decreased when it is combined with Modafinil.
FluconazoleThe metabolism of Modafinil can be decreased when combined with Fluconazole.
FlunisolideThe serum concentration of Flunisolide can be decreased when it is combined with Modafinil.
FlunitrazepamThe serum concentration of Flunitrazepam can be decreased when it is combined with Modafinil.
FluorometholoneThe serum concentration of Fluorometholone can be decreased when it is combined with Modafinil.
FluoxetineThe serum concentration of Fluoxetine can be decreased when it is combined with Modafinil.
FlurazepamThe serum concentration of Flurazepam can be decreased when it is combined with Modafinil.
FlutamideThe serum concentration of Flutamide can be decreased when it is combined with Modafinil.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be decreased when it is combined with Modafinil.
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be decreased when it is combined with Modafinil.
FluvastatinThe serum concentration of Fluvastatin can be decreased when it is combined with Modafinil.
FluvoxamineThe metabolism of Modafinil can be decreased when combined with Fluvoxamine.
FormoterolThe metabolism of Formoterol can be decreased when combined with Modafinil.
FosamprenavirThe serum concentration of Fosamprenavir can be decreased when it is combined with Modafinil.
FosamprenavirThe metabolism of Modafinil can be decreased when combined with Fosamprenavir.
FosaprepitantThe serum concentration of Modafinil can be increased when it is combined with Fosaprepitant.
FosphenytoinThe metabolism of Modafinil can be increased when combined with Fosphenytoin.
FulvestrantThe serum concentration of Fulvestrant can be decreased when it is combined with Modafinil.
Fusidic AcidThe serum concentration of Modafinil can be increased when it is combined with Fusidic Acid.
GalantamineThe serum concentration of Galantamine can be decreased when it is combined with Modafinil.
GefitinibThe serum concentration of Gefitinib can be decreased when it is combined with Modafinil.
GemfibrozilThe serum concentration of Gemfibrozil can be decreased when it is combined with Modafinil.
GliclazideThe metabolism of Gliclazide can be decreased when combined with Modafinil.
GlipizideThe serum concentration of Glipizide can be decreased when it is combined with Modafinil.
GlucosamineThe metabolism of Glucosamine can be decreased when combined with Modafinil.
GlyburideThe serum concentration of Glyburide can be decreased when it is combined with Modafinil.
GranisetronThe serum concentration of Granisetron can be decreased when it is combined with Modafinil.
GrepafloxacinThe serum concentration of Grepafloxacin can be decreased when it is combined with Modafinil.
GuanfacineThe serum concentration of Guanfacine can be decreased when it is combined with Modafinil.
HalofantrineThe serum concentration of Halofantrine can be decreased when it is combined with Modafinil.
HaloperidolThe serum concentration of Haloperidol can be decreased when it is combined with Modafinil.
HalothaneThe serum concentration of Halothane can be decreased when it is combined with Modafinil.
HexobarbitalThe serum concentration of Hexobarbital can be decreased when it is combined with Modafinil.
Histamine PhosphateThe serum concentration of Histamine Phosphate can be decreased when it is combined with Modafinil.
HydrocodoneThe serum concentration of Hydrocodone can be decreased when it is combined with Modafinil.
HydrocortisoneThe serum concentration of Hydrocortisone can be decreased when it is combined with Modafinil.
HydromorphoneThe serum concentration of Hydromorphone can be decreased when it is combined with Modafinil.
Hydroxyprogesterone caproateThe serum concentration of Hydroxyprogesterone caproate can be decreased when it is combined with Modafinil.
IbrutinibThe serum concentration of Ibrutinib can be decreased when it is combined with Modafinil.
IbuprofenThe metabolism of Ibuprofen can be decreased when combined with Modafinil.
IdelalisibThe serum concentration of Modafinil can be increased when it is combined with Idelalisib.
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Modafinil resulting in a loss in efficacy.
IloperidoneThe serum concentration of Iloperidone can be decreased when it is combined with Modafinil.
ImatinibThe serum concentration of Imatinib can be decreased when it is combined with Modafinil.
ImatinibThe metabolism of Modafinil can be decreased when combined with Imatinib.
ImipramineThe serum concentration of Imipramine can be decreased when it is combined with Modafinil.
ImiquimodThe serum concentration of Imiquimod can be decreased when it is combined with Modafinil.
IndacaterolThe serum concentration of Indacaterol can be decreased when it is combined with Modafinil.
IndapamideThe serum concentration of Indapamide can be decreased when it is combined with Modafinil.
IndinavirThe serum concentration of Indinavir can be decreased when it is combined with Modafinil.
IndinavirThe metabolism of Modafinil can be decreased when combined with Indinavir.
IndomethacinThe metabolism of Indomethacin can be decreased when combined with Modafinil.
Ipratropium bromideThe serum concentration of Ipratropium bromide can be decreased when it is combined with Modafinil.
IrinotecanThe serum concentration of Irinotecan can be decreased when it is combined with Modafinil.
IsavuconazoniumThe serum concentration of Isavuconazonium can be decreased when it is combined with Modafinil.
IsavuconazoniumThe metabolism of Modafinil can be decreased when combined with Isavuconazonium.
Isosorbide DinitrateThe serum concentration of Isosorbide Dinitrate can be decreased when it is combined with Modafinil.
Isosorbide MononitrateThe serum concentration of Isosorbide Mononitrate can be decreased when it is combined with Modafinil.
IsradipineThe serum concentration of Isradipine can be decreased when it is combined with Modafinil.
IsradipineThe metabolism of Modafinil can be decreased when combined with Isradipine.
ItraconazoleThe serum concentration of Itraconazole can be decreased when it is combined with Modafinil.
ItraconazoleThe metabolism of Modafinil can be decreased when combined with Itraconazole.
IvabradineThe serum concentration of Ivabradine can be decreased when it is combined with Modafinil.
IvacaftorThe serum concentration of Modafinil can be increased when it is combined with Ivacaftor.
IvacaftorThe serum concentration of Ivacaftor can be decreased when it is combined with Modafinil.
IvermectinThe serum concentration of Ivermectin can be decreased when it is combined with Modafinil.
IxabepiloneThe serum concentration of Ixabepilone can be decreased when it is combined with Modafinil.
IxazomibThe serum concentration of Ixazomib can be decreased when it is combined with Modafinil.
KetamineThe serum concentration of Ketamine can be decreased when it is combined with Modafinil.
KetazolamThe serum concentration of Ketazolam can be decreased when it is combined with Modafinil.
KetobemidoneThe serum concentration of Ketobemidone can be decreased when it is combined with Modafinil.
KetoconazoleThe serum concentration of Ketoconazole can be decreased when it is combined with Modafinil.
KetoconazoleThe metabolism of Modafinil can be decreased when combined with Ketoconazole.
LansoprazoleThe serum concentration of Lansoprazole can be decreased when it is combined with Modafinil.
LapatinibThe serum concentration of Lapatinib can be decreased when it is combined with Modafinil.
LaquinimodThe serum concentration of Laquinimod can be decreased when it is combined with Modafinil.
LenvatinibThe serum concentration of Lenvatinib can be decreased when it is combined with Modafinil.
LercanidipineThe serum concentration of Lercanidipine can be decreased when it is combined with Modafinil.
LetrozoleThe serum concentration of Letrozole can be decreased when it is combined with Modafinil.
LevobupivacaineThe serum concentration of Levobupivacaine can be decreased when it is combined with Modafinil.
LevocetirizineThe serum concentration of Levocetirizine can be decreased when it is combined with Modafinil.
Levomethadyl AcetateThe serum concentration of Levomethadyl Acetate can be decreased when it is combined with Modafinil.
LevomilnacipranThe serum concentration of Levomilnacipran can be decreased when it is combined with Modafinil.
LevonorgestrelThe serum concentration of Levonorgestrel can be decreased when it is combined with Modafinil.
LevothyroxineThe serum concentration of Levothyroxine can be decreased when it is combined with Modafinil.
LidocaineThe serum concentration of Lidocaine can be decreased when it is combined with Modafinil.
LisurideThe serum concentration of Lisuride can be decreased when it is combined with Modafinil.
LomitapideThe serum concentration of Lomitapide can be decreased when it is combined with Modafinil.
LoperamideThe serum concentration of Loperamide can be decreased when it is combined with Modafinil.
LopinavirThe serum concentration of Lopinavir can be decreased when it is combined with Modafinil.
LopinavirThe metabolism of Modafinil can be decreased when combined with Lopinavir.
LoratadineThe serum concentration of Loratadine can be decreased when it is combined with Modafinil.
LorcaserinThe serum concentration of Lorcaserin can be decreased when it is combined with Modafinil.
LosartanThe serum concentration of Losartan can be decreased when it is combined with Modafinil.
LovastatinThe serum concentration of Lovastatin can be decreased when it is combined with Modafinil.
LovastatinThe metabolism of Modafinil can be decreased when combined with Lovastatin.
LuliconazoleThe serum concentration of Modafinil can be increased when it is combined with Luliconazole.
LumefantrineThe serum concentration of Lumefantrine can be decreased when it is combined with Modafinil.
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Modafinil.
LurasidoneThe serum concentration of Lurasidone can be decreased when it is combined with Modafinil.
MacitentanThe serum concentration of Macitentan can be decreased when it is combined with Modafinil.
MaravirocThe serum concentration of Maraviroc can be decreased when it is combined with Modafinil.
MebendazoleThe serum concentration of Mebendazole can be decreased when it is combined with Modafinil.
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Modafinil.
MefloquineThe serum concentration of Mefloquine can be decreased when it is combined with Modafinil.
MelatoninThe metabolism of Melatonin can be decreased when combined with Modafinil.
MeloxicamThe serum concentration of Meloxicam can be decreased when it is combined with Modafinil.
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Modafinil.
MeprobamateThe metabolism of Meprobamate can be decreased when combined with Modafinil.
MethadoneThe serum concentration of Methadone can be decreased when it is combined with Modafinil.
MethaqualoneThe serum concentration of Methaqualone can be decreased when it is combined with Modafinil.
MethoxsalenThe serum concentration of Methoxsalen can be decreased when it is combined with Modafinil.
MethoxyfluraneThe serum concentration of Methoxyflurane can be decreased when it is combined with Modafinil.
MethsuximideThe metabolism of Methsuximide can be decreased when combined with Modafinil.
MethylphenobarbitalThe metabolism of Methylphenobarbital can be decreased when combined with Modafinil.
MethylprednisoloneThe serum concentration of Methylprednisolone can be decreased when it is combined with Modafinil.
MethyltestosteroneThe serum concentration of Methyltestosterone can be decreased when it is combined with Modafinil.
MetoprololThe metabolism of Metoprolol can be decreased when combined with Modafinil.
MetronidazoleThe serum concentration of Metronidazole can be decreased when it is combined with Modafinil.
MexiletineThe serum concentration of Mexiletine can be decreased when it is combined with Modafinil.
MianserinThe serum concentration of Mianserin can be decreased when it is combined with Modafinil.
MibefradilThe serum concentration of Mibefradil can be decreased when it is combined with Modafinil.
MiconazoleThe serum concentration of Miconazole can be decreased when it is combined with Modafinil.
MidazolamThe serum concentration of Midazolam can be decreased when it is combined with Modafinil.
MifepristoneThe serum concentration of Mifepristone can be decreased when it is combined with Modafinil.
MifepristoneThe metabolism of Modafinil can be decreased when combined with Mifepristone.
MirabegronThe serum concentration of Mirabegron can be decreased when it is combined with Modafinil.
MirtazapineThe serum concentration of Mirtazapine can be decreased when it is combined with Modafinil.
MitotaneThe serum concentration of Modafinil can be decreased when it is combined with Mitotane.
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Modafinil.
MontelukastThe serum concentration of Montelukast can be decreased when it is combined with Modafinil.
MorphineThe serum concentration of Morphine can be decreased when it is combined with Modafinil.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be decreased when it is combined with Modafinil.
NafcillinThe serum concentration of Modafinil can be decreased when it is combined with Nafcillin.
NaloxegolThe serum concentration of Naloxegol can be decreased when it is combined with Modafinil.
NaloxoneThe serum concentration of Naloxone can be decreased when it is combined with Modafinil.
NateglinideThe serum concentration of Nateglinide can be decreased when it is combined with Modafinil.
NefazodoneThe serum concentration of Nefazodone can be decreased when it is combined with Modafinil.
NefazodoneThe metabolism of Modafinil can be decreased when combined with Nefazodone.
NelfinavirThe serum concentration of Nelfinavir can be decreased when it is combined with Modafinil.
NelfinavirThe metabolism of Modafinil can be decreased when combined with Nelfinavir.
NetupitantThe serum concentration of Modafinil can be increased when it is combined with Netupitant.
NevirapineThe serum concentration of Nevirapine can be decreased when it is combined with Modafinil.
NevirapineThe metabolism of Modafinil can be decreased when combined with Nevirapine.
NicardipineThe serum concentration of Nicardipine can be decreased when it is combined with Modafinil.
NicotineThe serum concentration of Nicotine can be decreased when it is combined with Modafinil.
NifedipineThe serum concentration of Nifedipine can be decreased when it is combined with Modafinil.
NilotinibThe serum concentration of Nilotinib can be decreased when it is combined with Modafinil.
NilotinibThe metabolism of Modafinil can be decreased when combined with Nilotinib.
NilutamideThe metabolism of Nilutamide can be decreased when combined with Modafinil.
NilvadipineThe serum concentration of Nilvadipine can be decreased when it is combined with Modafinil.
NimodipineThe serum concentration of Nimodipine can be decreased when it is combined with Modafinil.
NintedanibThe serum concentration of Nintedanib can be decreased when it is combined with Modafinil.
NisoldipineThe serum concentration of Nisoldipine can be decreased when it is combined with Modafinil.
NitrazepamThe serum concentration of Nitrazepam can be decreased when it is combined with Modafinil.
NitrendipineThe serum concentration of Nitrendipine can be decreased when it is combined with Modafinil.
NorethisteroneThe serum concentration of Norethisterone can be decreased when it is combined with Modafinil.
NorgestrelThe serum concentration of Norgestrel can be decreased when it is combined with Modafinil.
NortriptylineThe serum concentration of Nortriptyline can be decreased when it is combined with Modafinil.
OlaparibThe serum concentration of Olaparib can be decreased when it is combined with Modafinil.
OlaparibThe metabolism of Modafinil can be decreased when combined with Olaparib.
OlopatadineThe serum concentration of Olopatadine can be decreased when it is combined with Modafinil.
OmeprazoleThe serum concentration of Omeprazole can be decreased when it is combined with Modafinil.
OndansetronThe serum concentration of Ondansetron can be decreased when it is combined with Modafinil.
OrphenadrineThe serum concentration of Orphenadrine can be decreased when it is combined with Modafinil.
OsimertinibThe serum concentration of Modafinil can be increased when it is combined with Osimertinib.
OspemifeneThe serum concentration of Ospemifene can be decreased when it is combined with Modafinil.
OxazepamThe serum concentration of Oxazepam can be decreased when it is combined with Modafinil.
OxiconazoleThe metabolism of Oxiconazole can be decreased when combined with Modafinil.
OxybutyninThe serum concentration of Oxybutynin can be decreased when it is combined with Modafinil.
OxycodoneThe serum concentration of Oxycodone can be decreased when it is combined with Modafinil.
OxymorphoneThe serum concentration of Oxymorphone can be decreased when it is combined with Modafinil.
PaclitaxelThe serum concentration of Paclitaxel can be decreased when it is combined with Modafinil.
PalbociclibThe serum concentration of Modafinil can be increased when it is combined with Palbociclib.
PalbociclibThe serum concentration of Palbociclib can be decreased when it is combined with Modafinil.
PalonosetronThe serum concentration of Palonosetron can be decreased when it is combined with Modafinil.
PanobinostatThe serum concentration of Panobinostat can be decreased when it is combined with Modafinil.
PantoprazoleThe serum concentration of Pantoprazole can be decreased when it is combined with Modafinil.
ParamethadioneThe serum concentration of Paramethadione can be decreased when it is combined with Modafinil.
ParamethasoneThe serum concentration of Paramethasone can be decreased when it is combined with Modafinil.
ParecoxibThe serum concentration of Parecoxib can be decreased when it is combined with Modafinil.
ParicalcitolThe serum concentration of Paricalcitol can be decreased when it is combined with Modafinil.
ParitaprevirThe serum concentration of Paritaprevir can be decreased when it is combined with Modafinil.
PazopanibThe serum concentration of Pazopanib can be decreased when it is combined with Modafinil.
PentamidineThe serum concentration of Pentamidine can be decreased when it is combined with Modafinil.
PentobarbitalThe metabolism of Modafinil can be increased when combined with Pentobarbital.
PerampanelThe serum concentration of Perampanel can be decreased when it is combined with Modafinil.
PergolideThe serum concentration of Pergolide can be decreased when it is combined with Modafinil.
PerhexilineThe serum concentration of Perhexiline can be decreased when it is combined with Modafinil.
PermethrinThe serum concentration of Permethrin can be decreased when it is combined with Modafinil.
PerphenazineThe serum concentration of Perphenazine can be decreased when it is combined with Modafinil.
PethidineThe serum concentration of Pethidine can be decreased when it is combined with Modafinil.
PhenacetinThe serum concentration of Phenacetin can be decreased when it is combined with Modafinil.
PhenobarbitalThe metabolism of Modafinil can be increased when combined with Phenobarbital.
PhenoxybenzamineThe serum concentration of Phenoxybenzamine can be decreased when it is combined with Modafinil.
PhenprocoumonThe serum concentration of Phenprocoumon can be decreased when it is combined with Modafinil.
PhenytoinThe serum concentration of Phenytoin can be decreased when it is combined with Modafinil.
PhenytoinThe metabolism of Modafinil can be increased when combined with Phenytoin.
PilocarpineThe serum concentration of Pilocarpine can be decreased when it is combined with Modafinil.
PimecrolimusThe serum concentration of Pimecrolimus can be decreased when it is combined with Modafinil.
PimozideThe serum concentration of Pimozide can be decreased when it is combined with Modafinil.
PinacidilThe serum concentration of Pinacidil can be decreased when it is combined with Modafinil.
PioglitazoneThe serum concentration of Pioglitazone can be decreased when it is combined with Modafinil.
PipotiazineThe serum concentration of Pipotiazine can be decreased when it is combined with Modafinil.
PodofiloxThe serum concentration of Podofilox can be decreased when it is combined with Modafinil.
PomalidomideThe serum concentration of Pomalidomide can be decreased when it is combined with Modafinil.
PonatinibThe serum concentration of Ponatinib can be decreased when it is combined with Modafinil.
PosaconazoleThe serum concentration of Posaconazole can be decreased when it is combined with Modafinil.
PosaconazoleThe metabolism of Modafinil can be decreased when combined with Posaconazole.
PrasugrelThe serum concentration of Prasugrel can be decreased when it is combined with Modafinil.
PravastatinThe serum concentration of Pravastatin can be decreased when it is combined with Modafinil.
PrazepamThe serum concentration of Prazepam can be decreased when it is combined with Modafinil.
PraziquantelThe serum concentration of Praziquantel can be decreased when it is combined with Modafinil.
PrednisoloneThe serum concentration of Prednisolone can be decreased when it is combined with Modafinil.
PrednisoneThe serum concentration of Prednisone can be decreased when it is combined with Modafinil.
PrimaquineThe serum concentration of Primaquine can be decreased when it is combined with Modafinil.
PrimidoneThe metabolism of Modafinil can be increased when combined with Primidone.
ProchlorperazineThe serum concentration of Prochlorperazine can be decreased when it is combined with Modafinil.
ProgesteroneThe serum concentration of Progesterone can be decreased when it is combined with Modafinil.
ProguanilThe serum concentration of Proguanil can be decreased when it is combined with Modafinil.
PromazineThe serum concentration of Promazine can be decreased when it is combined with Modafinil.
PropafenoneThe serum concentration of Propafenone can be decreased when it is combined with Modafinil.
PropofolThe serum concentration of Propofol can be decreased when it is combined with Modafinil.
PropranololThe serum concentration of Propranolol can be decreased when it is combined with Modafinil.
PyrazinamideThe serum concentration of Pyrazinamide can be decreased when it is combined with Modafinil.
QuazepamThe serum concentration of Quazepam can be decreased when it is combined with Modafinil.
QuetiapineThe serum concentration of Quetiapine can be decreased when it is combined with Modafinil.
QuinacrineThe serum concentration of Quinacrine can be decreased when it is combined with Modafinil.
QuinidineThe serum concentration of Quinidine can be decreased when it is combined with Modafinil.
QuinineThe serum concentration of Quinine can be decreased when it is combined with Modafinil.
RabeprazoleThe serum concentration of Rabeprazole can be decreased when it is combined with Modafinil.
RaloxifeneThe serum concentration of Raloxifene can be decreased when it is combined with Modafinil.
RamelteonThe serum concentration of Ramelteon can be decreased when it is combined with Modafinil.
RanitidineThe metabolism of Ranitidine can be decreased when combined with Modafinil.
RanolazineThe serum concentration of Ranolazine can be decreased when it is combined with Modafinil.
RanolazineThe metabolism of Modafinil can be decreased when combined with Ranolazine.
ReboxetineThe serum concentration of Reboxetine can be decreased when it is combined with Modafinil.
RegorafenibThe serum concentration of Regorafenib can be decreased when it is combined with Modafinil.
RepaglinideThe serum concentration of Repaglinide can be decreased when it is combined with Modafinil.
RetapamulinThe serum concentration of Retapamulin can be decreased when it is combined with Modafinil.
RifabutinThe serum concentration of Rifabutin can be decreased when it is combined with Modafinil.
RifabutinThe metabolism of Modafinil can be increased when combined with Rifabutin.
RifampicinThe serum concentration of Rifampicin can be decreased when it is combined with Modafinil.
RifampicinThe metabolism of Modafinil can be increased when combined with Rifampicin.
RifapentineThe metabolism of Modafinil can be increased when combined with Rifapentine.
RilpivirineThe serum concentration of Rilpivirine can be decreased when it is combined with Modafinil.
RimonabantThe serum concentration of Rimonabant can be decreased when it is combined with Modafinil.
RiociguatThe serum concentration of Riociguat can be decreased when it is combined with Modafinil.
RisperidoneThe serum concentration of Risperidone can be decreased when it is combined with Modafinil.
RitonavirThe serum concentration of Ritonavir can be decreased when it is combined with Modafinil.
RitonavirThe metabolism of Modafinil can be decreased when combined with Ritonavir.
RivaroxabanThe serum concentration of Rivaroxaban can be decreased when it is combined with Modafinil.
RofecoxibThe serum concentration of Rofecoxib can be decreased when it is combined with Modafinil.
RolapitantThe serum concentration of Rolapitant can be decreased when it is combined with Modafinil.
RomidepsinThe serum concentration of Romidepsin can be decreased when it is combined with Modafinil.
RopiniroleThe serum concentration of Ropinirole can be decreased when it is combined with Modafinil.
RopivacaineThe serum concentration of Ropivacaine can be decreased when it is combined with Modafinil.
RosuvastatinThe serum concentration of Rosuvastatin can be decreased when it is combined with Modafinil.
RotigotineThe serum concentration of Rotigotine can be decreased when it is combined with Modafinil.
RoxithromycinThe serum concentration of Roxithromycin can be decreased when it is combined with Modafinil.
RuxolitinibThe serum concentration of Ruxolitinib can be decreased when it is combined with Modafinil.
SalmeterolThe serum concentration of Salmeterol can be decreased when it is combined with Modafinil.
SaquinavirThe serum concentration of Saquinavir can be decreased when it is combined with Modafinil.
SaquinavirThe metabolism of Modafinil can be decreased when combined with Saquinavir.
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Modafinil.
SelegilineThe serum concentration of Selegiline can be decreased when it is combined with Modafinil.
SelexipagThe serum concentration of Selexipag can be decreased when it is combined with Modafinil.
SeratrodastThe serum concentration of Seratrodast can be decreased when it is combined with Modafinil.
SertindoleThe serum concentration of Sertindole can be decreased when it is combined with Modafinil.
SertralineThe serum concentration of Sertraline can be decreased when it is combined with Modafinil.
SevofluraneThe serum concentration of Sevoflurane can be decreased when it is combined with Modafinil.
SibutramineThe serum concentration of Sibutramine can be decreased when it is combined with Modafinil.
SildenafilThe serum concentration of Sildenafil can be decreased when it is combined with Modafinil.
SildenafilThe metabolism of Modafinil can be decreased when combined with Sildenafil.
SilodosinThe serum concentration of Silodosin can be decreased when it is combined with Modafinil.
SiltuximabThe serum concentration of Modafinil can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Modafinil can be increased when it is combined with Simeprevir.
SimeprevirThe serum concentration of Simeprevir can be decreased when it is combined with Modafinil.
SimvastatinThe serum concentration of Simvastatin can be decreased when it is combined with Modafinil.
SirolimusThe serum concentration of Sirolimus can be decreased when it is combined with Modafinil.
SitagliptinThe serum concentration of Sitagliptin can be decreased when it is combined with Modafinil.
SofosbuvirThe serum concentration of Sofosbuvir can be decreased when it is combined with Modafinil.
SolifenacinThe serum concentration of Solifenacin can be decreased when it is combined with Modafinil.
SonidegibThe serum concentration of Sonidegib can be decreased when it is combined with Modafinil.
SorafenibThe serum concentration of Sorafenib can be decreased when it is combined with Modafinil.
SpiramycinThe serum concentration of Spiramycin can be decreased when it is combined with Modafinil.
St. John's WortThe serum concentration of Modafinil can be decreased when it is combined with St. John's Wort.
StiripentolThe serum concentration of Modafinil can be increased when it is combined with Stiripentol.
SufentanilThe serum concentration of Sufentanil can be decreased when it is combined with Modafinil.
SulfadiazineThe serum concentration of Sulfadiazine can be decreased when it is combined with Modafinil.
SulfamethoxazoleThe serum concentration of Sulfamethoxazole can be decreased when it is combined with Modafinil.
SulfinpyrazoneThe serum concentration of Sulfinpyrazone can be decreased when it is combined with Modafinil.
SulfisoxazoleThe metabolism of Modafinil can be decreased when combined with Sulfisoxazole.
SunitinibThe serum concentration of Sunitinib can be decreased when it is combined with Modafinil.
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be decreased when it is combined with Modafinil.
Synthetic Conjugated Estrogens, BThe serum concentration of Synthetic Conjugated Estrogens, B can be decreased when it is combined with Modafinil.
TacrolimusThe serum concentration of Tacrolimus can be decreased when it is combined with Modafinil.
TadalafilThe serum concentration of Tadalafil can be decreased when it is combined with Modafinil.
TamoxifenThe serum concentration of Tamoxifen can be decreased when it is combined with Modafinil.
TamsulosinThe serum concentration of Tamsulosin can be decreased when it is combined with Modafinil.
TapentadolThe metabolism of Tapentadol can be decreased when combined with Modafinil.
TasosartanThe serum concentration of Tasosartan can be decreased when it is combined with Modafinil.
Taurochenodeoxycholic acidThe serum concentration of Taurochenodeoxycholic acid can be decreased when it is combined with Modafinil.
TelaprevirThe serum concentration of Telaprevir can be decreased when it is combined with Modafinil.
TelaprevirThe metabolism of Modafinil can be decreased when combined with Telaprevir.
TelithromycinThe serum concentration of Telithromycin can be decreased when it is combined with Modafinil.
TelithromycinThe metabolism of Modafinil can be decreased when combined with Telithromycin.
TemazepamThe serum concentration of Temazepam can be decreased when it is combined with Modafinil.
TemsirolimusThe serum concentration of Temsirolimus can be decreased when it is combined with Modafinil.
TeniposideThe serum concentration of Teniposide can be decreased when it is combined with Modafinil.
TerbinafineThe serum concentration of Terbinafine can be decreased when it is combined with Modafinil.
TerfenadineThe serum concentration of Terfenadine can be decreased when it is combined with Modafinil.
TesmilifeneThe serum concentration of Tesmilifene can be decreased when it is combined with Modafinil.
TestosteroneThe serum concentration of Testosterone can be decreased when it is combined with Modafinil.
TetracyclineThe serum concentration of Tetracycline can be decreased when it is combined with Modafinil.
ThalidomideThe metabolism of Thalidomide can be decreased when combined with Modafinil.
TheophyllineThe serum concentration of Theophylline can be decreased when it is combined with Modafinil.
ThioridazineThe metabolism of Thioridazine can be decreased when combined with Modafinil.
ThiotepaThe serum concentration of Thiotepa can be decreased when it is combined with Modafinil.
TiagabineThe serum concentration of Tiagabine can be decreased when it is combined with Modafinil.
TicagrelorThe serum concentration of Ticagrelor can be decreased when it is combined with Modafinil.
TiclopidineThe serum concentration of Ticlopidine can be decreased when it is combined with Modafinil.
TiclopidineThe metabolism of Modafinil can be decreased when combined with Ticlopidine.
TimololThe metabolism of Timolol can be decreased when combined with Modafinil.
TinidazoleThe serum concentration of Tinidazole can be decreased when it is combined with Modafinil.
TiotropiumThe serum concentration of Tiotropium can be decreased when it is combined with Modafinil.
TipranavirThe serum concentration of Tipranavir can be decreased when it is combined with Modafinil.
TocilizumabThe serum concentration of Modafinil can be decreased when it is combined with Tocilizumab.
TofacitinibThe serum concentration of Tofacitinib can be decreased when it is combined with Modafinil.
TolbutamideThe metabolism of Tolbutamide can be decreased when combined with Modafinil.
TolterodineThe serum concentration of Tolterodine can be decreased when it is combined with Modafinil.
TolvaptanThe serum concentration of Tolvaptan can be decreased when it is combined with Modafinil.
ToremifeneThe serum concentration of Toremifene can be decreased when it is combined with Modafinil.
TrabectedinThe serum concentration of Trabectedin can be decreased when it is combined with Modafinil.
TramadolThe serum concentration of Tramadol can be decreased when it is combined with Modafinil.
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be decreased when it is combined with Modafinil.
TrazodoneThe serum concentration of Trazodone can be decreased when it is combined with Modafinil.
TretinoinThe serum concentration of Tretinoin can be decreased when it is combined with Modafinil.
TriamcinoloneThe serum concentration of Triamcinolone can be decreased when it is combined with Modafinil.
TriazolamThe serum concentration of Triazolam can be decreased when it is combined with Modafinil.
TrimethadioneThe serum concentration of Trimethadione can be decreased when it is combined with Modafinil.
TrimethoprimThe serum concentration of Trimethoprim can be decreased when it is combined with Modafinil.
TrimipramineThe serum concentration of Trimipramine can be decreased when it is combined with Modafinil.
TroglitazoneThe serum concentration of Troglitazone can be decreased when it is combined with Modafinil.
TroleandomycinThe serum concentration of Troleandomycin can be decreased when it is combined with Modafinil.
UdenafilThe serum concentration of Udenafil can be decreased when it is combined with Modafinil.
UlipristalThe serum concentration of Ulipristal can be decreased when it is combined with Modafinil.
ValdecoxibThe serum concentration of Valdecoxib can be decreased when it is combined with Modafinil.
Valproic AcidThe metabolism of Valproic Acid can be decreased when combined with Modafinil.
VandetanibThe serum concentration of Vandetanib can be decreased when it is combined with Modafinil.
VanoxerineThe serum concentration of Vanoxerine can be decreased when it is combined with Modafinil.
VardenafilThe serum concentration of Vardenafil can be decreased when it is combined with Modafinil.
VemurafenibThe serum concentration of Vemurafenib can be decreased when it is combined with Modafinil.
VenlafaxineThe serum concentration of Venlafaxine can be decreased when it is combined with Modafinil.
VenlafaxineThe metabolism of Modafinil can be decreased when combined with Venlafaxine.
VerapamilThe serum concentration of Verapamil can be decreased when it is combined with Modafinil.
VerapamilThe metabolism of Modafinil can be decreased when combined with Verapamil.
VicrivirocThe serum concentration of Vicriviroc can be decreased when it is combined with Modafinil.
VilanterolThe serum concentration of Vilanterol can be decreased when it is combined with Modafinil.
VilazodoneThe serum concentration of Vilazodone can be decreased when it is combined with Modafinil.
VinblastineThe serum concentration of Vinblastine can be decreased when it is combined with Modafinil.
VincristineThe serum concentration of Vincristine can be decreased when it is combined with Modafinil.
VindesineThe serum concentration of Vindesine can be decreased when it is combined with Modafinil.
VinorelbineThe serum concentration of Vinorelbine can be decreased when it is combined with Modafinil.
VismodegibThe serum concentration of Vismodegib can be decreased when it is combined with Modafinil.
VoriconazoleThe serum concentration of Voriconazole can be decreased when it is combined with Modafinil.
VoriconazoleThe metabolism of Modafinil can be decreased when combined with Voriconazole.
VortioxetineThe serum concentration of Vortioxetine can be decreased when it is combined with Modafinil.
WarfarinThe serum concentration of Warfarin can be decreased when it is combined with Modafinil.
YohimbineThe serum concentration of Yohimbine can be decreased when it is combined with Modafinil.
ZafirlukastThe serum concentration of Zafirlukast can be decreased when it is combined with Modafinil.
ZalcitabineThe serum concentration of Zalcitabine can be decreased when it is combined with Modafinil.
ZaleplonThe serum concentration of Zaleplon can be decreased when it is combined with Modafinil.
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Modafinil.
ZileutonThe serum concentration of Zileuton can be decreased when it is combined with Modafinil.
ZiprasidoneThe serum concentration of Ziprasidone can be decreased when it is combined with Modafinil.
ZiprasidoneThe metabolism of Modafinil can be decreased when combined with Ziprasidone.
ZolpidemThe serum concentration of Zolpidem can be decreased when it is combined with Modafinil.
ZomepiracThe serum concentration of Zomepirac can be decreased when it is combined with Modafinil.
ZonisamideThe serum concentration of Zonisamide can be decreased when it is combined with Modafinil.
ZopicloneThe serum concentration of Zopiclone can be decreased when it is combined with Modafinil.
Food Interactions
  • Take without regard to meals.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Monoamine transmembrane transporter activity
Specific Function:
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.
Gene Name:
SLC6A3
Uniprot ID:
Q01959
Molecular Weight:
68494.255 Da
References
  1. Zhou J, He R, Johnson KM, Ye Y, Kozikowski AP: Piperidine-based nocaine/modafinil hybrid ligands as highly potent monoamine transporter inhibitors: efficient drug discovery by rational lead hybridization. J Med Chem. 2004 Nov 18;47(24):5821-4. [PubMed:15537337 ]
  2. Madras BK, Xie Z, Lin Z, Jassen A, Panas H, Lynch L, Johnson R, Livni E, Spencer TJ, Bonab AA, Miller GM, Fischman AJ: Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro. J Pharmacol Exp Ther. 2006 Nov;319(2):561-9. Epub 2006 Aug 2. [PubMed:16885432 ]
  3. Swanson JM: Role of executive function in ADHD. J Clin Psychiatry. 2003;64 Suppl 14:35-9. [PubMed:14658934 ]
  4. Dopheide MM, Morgan RE, Rodvelt KR, Schachtman TR, Miller DK: Modafinil evokes striatal [(3)H]dopamine release and alters the subjective properties of stimulants. Eur J Pharmacol. 2007 Jul 30;568(1-3):112-23. Epub 2007 Apr 5. [PubMed:17477916 ]
  5. Wisor JP, Nishino S, Sora I, Uhl GH, Mignot E, Edgar DM: Dopaminergic role in stimulant-induced wakefulness. J Neurosci. 2001 Mar 1;21(5):1787-94. [PubMed:11222668 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
partial agonist
General Function:
Protein heterodimerization activity
Specific Function:
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
Gene Name:
ADRA1B
Uniprot ID:
P35368
Molecular Weight:
56835.375 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Chen CR, Qu WM, Qiu MH, Xu XH, Yao MH, Urade Y, Huang ZL: Modafinil exerts a dose-dependent antiepileptic effect mediated by adrenergic alpha1 and histaminergic H1 receptors in mice. Neuropharmacology. 2007 Sep;53(4):534-41. Epub 2007 Jun 30. [PubMed:17681557 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitorinducer
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Robertson P Jr, Hellriegel ET: Clinical pharmacokinetic profile of modafinil. Clin Pharmacokinet. 2003;42(2):123-37. [PubMed:12537513 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitorinducer
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitorinducer
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitorinducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitorinducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitorinducer
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
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Drug created on June 13, 2005 07:24 / Updated on September 25, 2016 03:31