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Identification
NameClonazepam
Accession NumberDB01068  (APRD00054)
TypeSmall Molecule
GroupsApproved, Illicit
DescriptionAn anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of gamma-aminobutyric acid receptor responses. [PubChem]
Structure
Thumb
Synonyms
1,3-dihydro-7-Nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one
5-(2-Chloro-phenyl)-7-nitro-1,3-dihydro-benzo[e][1,4]diazepin-2-one
5-(2-Chlorophenyl)-7-nitro-1H-benzo[e][1,4]diazepin-2(3H)-one
5-(O-Chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one
CLONAZEPAM
Clonazepamum
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Accel-clonazepamtablet0.5 mgoralAccel Pharma IncNot applicableNot applicableCanada
Accel-clonazepamtablet1.0 mgoralAccel Pharma IncNot applicableNot applicableCanada
Accel-clonazepamtablet2.0 mgoralAccel Pharma IncNot applicableNot applicableCanada
Clonapamtablet1.0 mgoralValeant Canada Lp Valeant Canada S.E.C.1997-01-31Not applicableCanada
Clonapamtablet2.0 mgoralValeant Canada Lp Valeant Canada S.E.C.1997-02-28Not applicableCanada
Clonapamtablet0.5 mgoralValeant Canada Lp Valeant Canada S.E.C.1997-01-31Not applicableCanada
Clonazepamtablet1 mgoralMeliapharm Inc2010-10-202014-06-25Canada
Clonazepamtablet0.25 mgoralSivem Pharmaceuticals Ulc2015-07-09Not applicableCanada
Clonazepamtablet2 mgoralMeliapharm Inc2010-10-202014-06-25Canada
Clonazepamtablet0.5 mgoralSivem Pharmaceuticals Ulc2015-07-09Not applicableCanada
Clonazepamtablet1 mgoralSivem Pharmaceuticals Ulc2015-07-09Not applicableCanada
Clonazepamtablet2 mgoralSivem Pharmaceuticals Ulc2015-07-09Not applicableCanada
Clonazepam-0.5 - Tab 0.5mgtablet.5 mgoralPro Doc Limitee1996-12-042010-07-13Canada
Clonazepam-2 - Tab 2mgtablet2 mgoralPro Doc Limitee1996-12-042010-07-13Canada
Clonazepam-Rtablet0.5 mgoralMeliapharm Inc2010-10-202014-06-25Canada
Co Clonazepamtablet0.5 mgoralCobalt Pharmaceuticals Company2006-02-01Not applicableCanada
Co Clonazepamtablet1.0 mgoralCobalt Pharmaceuticals Company2006-02-01Not applicableCanada
Co Clonazepamtablet2.0 mgoralCobalt Pharmaceuticals Company2006-02-01Not applicableCanada
Dom-clonazepam - Tab 0.5mgtablet.5 mgoralDominion Pharmacal1996-08-14Not applicableCanada
Dom-clonazepam - Tab 2mgtablet2 mgoralDominion Pharmacal1995-12-31Not applicableCanada
Dom-clonazepam-R - Tab 0.5mgtablet.5 mgoralDominion Pharmacal1996-08-20Not applicableCanada
Klonopintablet1 mg/1oralGenentech, Inc.1975-06-02Not applicableUs
Klonopintablet1 mg/1oralSTAT Rx USA LLC1975-06-02Not applicableUs
Klonopintablet.5 mg/1oralGenentech, Inc.1975-06-02Not applicableUs
Klonopintablet.5 mg/1oralCardinal Health1982-01-01Not applicableUs
Klonopintablet2 mg/1oralGenentech, Inc.1975-06-02Not applicableUs
Klonopintablet1 mg/1oralCardinal Health1982-01-01Not applicableUs
Klonopintablet.5 mg/1oralSTAT Rx USA LLC1975-06-02Not applicableUs
Mylan-clonazepamtablet2 mgoralMylan Pharmaceuticals Ulc1997-03-20Not applicableCanada
Mylan-clonazepamtablet0.5 mgoralMylan Pharmaceuticals Ulc1997-03-20Not applicableCanada
Nu-clonazepam - Tab 0.5mgtablet.5 mgoralNu Pharm Inc1995-12-312012-09-04Canada
Nu-clonazepam - Tab 2mgtablet2 mgoralNu Pharm Inc1995-12-312012-09-04Canada
PHL-clonazepam - 0.25mgtablet0.25 mgoralPharmel Inc1998-02-172009-10-30Canada
PHL-clonazepam - Tab 0.5mgtablet.5 mgoralPharmel Inc2003-04-08Not applicableCanada
PHL-clonazepam - Tab 1mgtablet1 mgoralPharmel Inc1997-11-28Not applicableCanada
PHL-clonazepam - Tab 2mgtablet2 mgoralPharmel Inc1997-11-28Not applicableCanada
PHL-clonazepam-Rtablet0.5 mgoralPharmel Inc2004-12-02Not applicableCanada
PMS-clonazepam Tab 0.5mgtablet0.5 mgoralPharmascience Inc1993-12-31Not applicableCanada
PMS-clonazepam Tab 1.0mgtablet1 mgoralPharmascience Inc1993-12-31Not applicableCanada
PMS-clonazepam Tab 2mgtablet2 mgoralPharmascience Inc1993-12-31Not applicableCanada
PMS-clonazepam- Tab 0.25mgtablet0.25 mgoralPharmascience Inc1995-12-31Not applicableCanada
PMS-clonazepam-R Tab 0.5mgtablet0.5 mgoralPharmascience Inc1996-12-31Not applicableCanada
Pro-clonazepamtablet0.5 mgoralPro Doc Limitee2008-07-28Not applicableCanada
Pro-clonazepamtablet1 mgoralPro Doc Limitee2008-07-09Not applicableCanada
Pro-clonazepamtablet2 mgoralPro Doc Limitee2008-07-09Not applicableCanada
Ratio-clonazepamtablet0.5 mgoralRatiopharm Inc Division Of Teva Canada Limited1994-12-312015-10-26Canada
Ratio-clonazepamtablet2 mgoralRatiopharm Inc Division Of Teva Canada Limited1994-12-312015-10-26Canada
Riva-clonazepamtablet0.5 mgoralLaboratoire Riva Inc2000-05-23Not applicableCanada
Riva-clonazepam 2 mgtablet2 mgoralLaboratoire Riva Inc2000-05-23Not applicableCanada
Rivotril 0.5tabtablet0.5 mgoralHoffmann La Roche Limited1977-12-31Not applicableCanada
Rivotril 2tabtablet2 mgoralHoffmann La Roche Limited1977-12-31Not applicableCanada
Sandoz Clonazepamtablet0.5 mgoralSandoz Canada Incorporated1997-12-02Not applicableCanada
Sandoz Clonazepamtablet1 mgoralSandoz Canada Incorporated1997-12-02Not applicableCanada
Sandoz Clonazepamtablet2 mgoralSandoz Canada Incorporated1997-12-02Not applicableCanada
Teva-clonazepamtablet0.5 mgoralTeva Canada Limited1999-08-16Not applicableCanada
Teva-clonazepamtablet2 mgoralTeva Canada Limited1999-08-16Not applicableCanada
Zym-clonazepamtablet0.5 mgoralZymcan Pharmaceuticals Inc2009-02-262010-02-12Canada
Zym-clonazepamtablet1 mgoralZymcan Pharmaceuticals Inc2009-02-262014-06-16Canada
Zym-clonazepamtablet0.5 mgoralZymcan Pharmaceuticals Inc2010-03-122014-06-16Canada
Zym-clonazepamtablet2 mgoralZymcan Pharmaceuticals Inc2009-02-262014-06-16Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-clonazepam - Tab 0.5mgtablet.5 mgoralApotex Inc1995-12-31Not applicableCanada
Apo-clonazepam - Tab 2mgtablet2 mgoralApotex Inc1995-12-31Not applicableCanada
Clonazepamtablet.5 mg/1oralUpsher Smith Laboratories, Inc.2014-09-25Not applicableUs
Clonazepamtablet1 mg/1oralGolden State Medical Supply, Inc.2013-10-18Not applicableUs
Clonazepamtablet.5 mg/1oralActavis Elizabeth LLC2009-02-13Not applicableUs
Clonazepamtablet2 mg/1oralTYA Pharmaceuticals2009-02-13Not applicableUs
Clonazepamtablet1 mg/1oralAidarex Pharmaceuticals LLC2006-06-28Not applicableUs
Clonazepamtablet.5 mg/1oralPreferred Pharmaceuticals, Inc.2012-01-17Not applicableUs
Clonazepamtablet, orally disintegrating.5 mg/1oralPar Pharmaceutical, Inc.2005-08-05Not applicableUs
Clonazepamtablet1 mg/1oralREMEDYREPACK INC.2013-02-18Not applicableUs
Clonazepamtablet1 mg/1oralCardinal Health1997-08-29Not applicableUs
Clonazepamtablet, orally disintegrating.5 mg/1oralBarr Laboratories Inc.2005-08-11Not applicableUs
Clonazepamtablet2 mg/1oralPd Rx Pharmaceuticals, Inc.1997-08-29Not applicableUs
Clonazepamtablet.5 mg/1oralTeva Pharmaceuticals USA Inc1996-09-18Not applicableUs
Clonazepamtablet1 mg/1oralbryant ranch prepack2006-06-28Not applicableUs
Clonazepamtablet2 mg/1oralSTAT Rx USA LLC2009-02-13Not applicableUs
Clonazepamtablet.5 mg/1oralAphena Pharma Solutions Tennessee, Llc2009-02-13Not applicableUs
Clonazepamtablet1 mg/1oralAphena Pharma Solutions Tennessee, Llc2006-06-28Not applicableUs
Clonazepamtablet.5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1996-09-18Not applicableUs
Clonazepamtablet.5 mg/1oralUnit Dose Services2009-02-13Not applicableUs
Clonazepamtablet.5 mg/1oralA S Medication Solutions Llc2006-06-28Not applicableUs
Clonazepamtablet.5 mg/1oralH.J. Harkins Company, Inc.2009-02-13Not applicableUs
Clonazepamtablet.5 mg/1oralCardinal Health2009-02-13Not applicableUs
Clonazepamtablet1 mg/1oralMajor Pharmaceuticals2010-05-14Not applicableUs
Clonazepamtablet1 mg/1oralDIRECT RX2014-01-01Not applicableUs
Clonazepamtablet1 mg/1oralMylan Pharmaceuticals Inc.1998-10-20Not applicableUs
Clonazepamtablet.5 mg/1oralContract Pharmacy Services Pa2010-07-01Not applicableUs
Clonazepamtablet1 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC1996-09-17Not applicableUs
Clonazepamtablet.5 mg/1oralProficient Rx LP2011-06-03Not applicableUs
Clonazepamtablet.5 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-12-19Not applicableUs
Clonazepamtablet.5 mg/1oralPreferred Pharmaceuticals, Inc.2014-07-28Not applicableUs
Clonazepamtablet.5 mg/1oralREMEDYREPACK INC.2011-06-22Not applicableUs
Clonazepamtablet2 mg/1oralMylan Institutional Inc.1997-07-15Not applicableUs
Clonazepamtablet2 mg/1oralPhysicians Total Care, Inc.2009-06-26Not applicableUs
Clonazepamtablet1 mg/1oralQualitest Pharmaceuticals2006-06-28Not applicableUs
Clonazepamtablet1 mg/1oralCaraco Pharmaceutical Laboratories, Ltd.2001-08-31Not applicableUs
Clonazepamtablet.5 mg/1oralEon Labs, Inc.1997-08-29Not applicableUs
Clonazepamtablet1 mg/1oralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2007-08-02Not applicableUs
Clonazepamtablet.5 mg/1oralRebel Distributors2009-06-22Not applicableUs
Clonazepamtablet1 mg/1oralUpsher Smith Laboratories, Inc.2014-09-25Not applicableUs
Clonazepamtablet2 mg/1oralGolden State Medical Supply, Inc.2013-10-18Not applicableUs
Clonazepamtablet1 mg/1oralActavis Elizabeth LLC2009-02-13Not applicableUs
Clonazepamtablet1 mg/1oralDispensing Solutions, Inc.2006-06-28Not applicableUs
Clonazepamtablet.5 mg/1oralAidarex Pharmaceuticals LLC2006-06-28Not applicableUs
Clonazepamtablet.5 mg/1oralMc Kesson Contract Packaging2011-10-11Not applicableUs
Clonazepamtablet, orally disintegrating1 mg/1oralPar Pharmaceutical, Inc.2005-08-05Not applicableUs
Clonazepamtablet1 mg/1oralREMEDYREPACK INC.2013-12-31Not applicableUs
Clonazepamtablet2 mg/1oralCardinal Health1997-08-29Not applicableUs
Clonazepamtablet, orally disintegrating1 mg/1oralBarr Laboratories Inc.2005-08-11Not applicableUs
Clonazepamtablet1 mg/1oralPd Rx Pharmaceuticals, Inc.1997-08-29Not applicableUs
Clonazepamtablet1 mg/1oralTeva Pharmaceuticals USA Inc1996-09-17Not applicableUs
Clonazepamtablet.5 mg/1oralbryant ranch prepack2006-06-28Not applicableUs
Clonazepamtablet.5 mg/1oralAccord Healthcare Inc.2010-11-24Not applicableUs
Clonazepamtablet2 mg/1oralAphena Pharma Solutions Tennessee, Llc2009-02-13Not applicableUs
Clonazepamtablet2 mg/1oralAphena Pharma Solutions Tennessee, Llc2006-06-28Not applicableUs
Clonazepamtablet1 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1996-09-17Not applicableUs
Clonazepamtablet1 mg/1oralUnit Dose Services2011-12-07Not applicableUs
Clonazepamtablet2 mg/1oralA S Medication Solutions Llc2006-06-28Not applicableUs
Clonazepamtablet2 mg/1oralMylan Pharmaceuticals Inc.1998-10-20Not applicableUs
Clonazepamtablet1 mg/1oralContract Pharmacy Services Pa2010-07-01Not applicableUs
Clonazepamtablet1 mg/1oralSTAT Rx USA LLC2006-06-28Not applicableUs
Clonazepamtablet1 mg/1oralA S Medication Solutions Llc2006-06-28Not applicableUs
Clonazepamtablet1 mg/1oralH.J. Harkins Company, Inc.2009-02-13Not applicableUs
Clonazepamtablet1 mg/1oralCardinal Health2009-02-13Not applicableUs
Clonazepamtablet2 mg/1oralMajor Pharmaceuticals2010-06-17Not applicableUs
Clonazepamtablet2 mg/1oralDIRECT RX2014-01-01Not applicableUs
Clonazepamtablet2 mg/1oralCaraco Pharmaceutical Laboratories, Ltd.2001-08-31Not applicableUs
Clonazepamtablet1 mg/1oralEon Labs, Inc.1997-08-29Not applicableUs
Clonazepamtablet.5 mg/1oralTYA Pharmaceuticals2010-11-24Not applicableUs
Clonazepamtablet1 mg/1oralRebel Distributors2009-06-22Not applicableUs
Clonazepamtablet1 mg/1oralPreferred Pharmaceuticals, Inc.2014-04-02Not applicableUs
Clonazepamtablet, orally disintegrating.125 mg/1oralPar Pharmaceutical, Inc.2005-08-05Not applicableUs
Clonazepamtablet1 mg/1oralNorthwind Pharmaceuticals2014-06-01Not applicableUs
Clonazepamtablet, orally disintegrating.25 mg/1oralPhysicians Total Care, Inc.2011-01-14Not applicableUs
Clonazepamtablet2 mg/1oralQualitest Pharmaceuticals2006-06-28Not applicableUs
Clonazepamtablet2 mg/1oralUpsher Smith Laboratories, Inc.2014-09-25Not applicableUs
Clonazepamtablet2 mg/1oralREMEDYREPACK INC.2015-02-13Not applicableUs
Clonazepamtablet2 mg/1oralActavis Elizabeth LLC2009-02-13Not applicableUs
Clonazepamtablet2 mg/1oralDispensing Solutions, Inc.2006-06-28Not applicableUs
Clonazepamtablet2 mg/1oralAidarex Pharmaceuticals LLC2006-06-28Not applicableUs
Clonazepamtablet1 mg/1oralMc Kesson Contract Packaging2011-10-12Not applicableUs
Clonazepamtablet, orally disintegrating2 mg/1oralPar Pharmaceutical, Inc.2005-08-05Not applicableUs
Clonazepamtablet2 mg/1oralREMEDYREPACK INC.2014-06-03Not applicableUs
Clonazepamtablet.5 mg/1oralCardinal Health2009-12-31Not applicableUs
Clonazepamtablet, orally disintegrating2 mg/1oralBarr Laboratories Inc.2005-08-11Not applicableUs
Clonazepamtablet.5 mg/1oralPd Rx Pharmaceuticals, Inc.2006-06-28Not applicableUs
Clonazepamtablet2 mg/1oralTeva Pharmaceuticals USA Inc1996-09-18Not applicableUs
Clonazepamtablet2 mg/1oralbryant ranch prepack2006-06-28Not applicableUs
Clonazepamtablet1 mg/1oralAccord Healthcare Inc.2010-11-24Not applicableUs
Clonazepamtablet.5 mg/1oralAphena Pharma Solutions Tennessee, Llc2006-06-28Not applicableUs
Clonazepamtablet.5 mg/1oralMedsource Pharmaceuticals2009-02-13Not applicableUs
Clonazepamtablet2 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1996-09-18Not applicableUs
Clonazepamtablet.5 mg/1oralMylan Institutional Inc.1997-07-15Not applicableUs
Clonazepamtablet.5 mg/1oralPhysicians Total Care, Inc.2005-05-16Not applicableUs
Clonazepamtablet.5 mg/1oralProficient Rx LP1996-09-18Not applicableUs
Clonazepamtablet, orally disintegrating.125 mg/1oralBarr Laboratories Inc.2005-08-10Not applicableUs
Clonazepamtablet2 mg/1oralContract Pharmacy Services Pa2010-07-01Not applicableUs
Clonazepamtablet1 mg/1oralSTAT Rx USA LLC2009-02-13Not applicableUs
Clonazepamtablet.5 mg/1oralA S Medication Solutions Llc2006-06-28Not applicableUs
Clonazepamtablet2 mg/1oralH.J. Harkins Company, Inc.2009-02-13Not applicableUs
Clonazepamtablet2 mg/1oralCardinal Health2009-02-13Not applicableUs
Clonazepamtablet.5 mg/1oralSTAT Rx USA LLC2009-02-13Not applicableUs
Clonazepamtablet.5 mg/1oralGolden State Medical Supply, Inc.2013-10-18Not applicableUs
Clonazepamtablet2 mg/1oralEon Labs, Inc.1997-08-29Not applicableUs
Clonazepamtablet1 mg/1oralTYA Pharmaceuticals2009-02-13Not applicableUs
Clonazepamtablet2 mg/1oralRebel Distributors2009-06-22Not applicableUs
Clonazepamtablet1 mg/1oralPreferred Pharmaceuticals, Inc.2012-01-17Not applicableUs
Clonazepamtablet, orally disintegrating.25 mg/1oralPar Pharmaceutical, Inc.2005-08-05Not applicableUs
Clonazepamtablet.5 mg/1oralREMEDYREPACK INC.2013-02-25Not applicableUs
Clonazepamtablet.5 mg/1oralCardinal Health1997-08-29Not applicableUs
Clonazepamtablet.5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2009-02-13Not applicableUs
Clonazepamtablet.5 mg/1oralMajor Pharmaceuticals2010-05-14Not applicableUs
Clonazepamtablet.5 mg/1oralDIRECT RX2014-01-01Not applicableUs
Clonazepamtablet.5 mg/1oralMylan Pharmaceuticals Inc.1998-10-20Not applicableUs
Clonazepamtablet.5 mg/1oralDispensing Solutions, Inc.2006-06-28Not applicableUs
Clonazepamtablet.5 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2009-02-13Not applicableUs
Clonazepamtablet2 mg/1oralMc Kesson Contract Packaging2011-10-18Not applicableUs
Clonazepamtablet1 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-12-19Not applicableUs
Clonazepamtablet1 mg/1oralREMEDYREPACK INC.2014-06-16Not applicableUs
Clonazepamtablet1 mg/1oralCardinal Health2009-12-31Not applicableUs
Clonazepamtablet1 mg/1oralPhysicians Total Care, Inc.2003-09-25Not applicableUs
Clonazepamtablet.5 mg/1oralQualitest Pharmaceuticals2006-06-28Not applicableUs
Clonazepamtablet.5 mg/1oralCaraco Pharmaceutical Laboratories, Ltd.2001-08-31Not applicableUs
Clonazepamtablet.5 mg/1oralKAISER FOUNDATION HOSPITALS2014-11-11Not applicableUs
Clonazepamtablet.5 mg/1oralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2007-08-01Not applicableUs
Clonazepamtablet2 mg/1oralAccord Healthcare Inc.2010-11-24Not applicableUs
Clonazepamtablet2 mg/1oralPreferred Pharmaceuticals, Inc.2014-07-28Not applicableUs
Clonazepamtablet.5 mg/1oralREMEDYREPACK INC.2010-09-22Not applicableUs
Clonazepamtablet1 mg/1oralMylan Institutional Inc.1997-07-15Not applicableUs
Clonazepamtablet1 mg/1oralProficient Rx LP1996-09-17Not applicableUs
Clonazepamtablet, orally disintegrating.25 mg/1oralBarr Laboratories Inc.2005-08-10Not applicableUs
Clonazepamtablet1 mg/1oralAphena Pharma Solutions Tennessee, Llc2009-02-13Not applicableUs
Clonazepamtablet.5 mg/1oralPd Rx Pharmaceuticals, Inc.1997-08-29Not applicableUs
Clonazepamtablet1 mg/1oralREMEDYREPACK INC.2016-02-05Not applicableUs
Clonazepamtablet1 mg/1oralUnit Dose Services2011-12-07Not applicableUs
Clonazepamtablet1 mg/1oralA S Medication Solutions Llc2006-06-28Not applicableUs
Clonazepamtablet.5 mg/1oralCardinal Health2007-08-01Not applicableUs
Clonazepamtablet1 mg/1oralSTAT Rx USA LLC2009-02-13Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
AntelepsinAWD
IktorivilRoche
RivotrilRoche
Brand mixturesNot Available
SaltsNot Available
Categories
UNII5PE9FDE8GB
CAS number1622-61-3
WeightAverage: 315.711
Monoisotopic: 315.041068908
Chemical FormulaC15H10ClN3O3
InChI KeyInChIKey=DGBIGWXXNGSACT-UHFFFAOYSA-N
InChI
InChI=1S/C15H10ClN3O3/c16-12-4-2-1-3-10(12)15-11-7-9(19(21)22)5-6-13(11)18-14(20)8-17-15/h1-7H,8H2,(H,18,20)
IUPAC Name
5-(2-chlorophenyl)-7-nitro-2,3-dihydro-1H-1,4-benzodiazepin-2-one
SMILES
[O-][N+](=O)C1=CC2=C(NC(=O)CN=C2C2=CC=CC=C2Cl)C=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as 1,4-benzodiazepines. These are organic compounds containing a benzene ring fused to a 1,4-azepine.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassBenzodiazepines
Sub Class1,4-benzodiazepines
Direct Parent1,4-benzodiazepines
Alternative Parents
Substituents
  • 1,4-benzodiazepine
  • Halobenzene
  • Chlorobenzene
  • Benzenoid
  • Monocyclic benzene moiety
  • Aryl halide
  • Aryl chloride
  • Organic nitro compound
  • Secondary carboxylic acid amide
  • Organic nitrite
  • C-nitro compound
  • Lactam
  • Ketimine
  • Carboxamide group
  • Azacycle
  • Organic 1,3-dipolar compound
  • Propargyl-type 1,3-dipolar organic compound
  • Allyl-type 1,3-dipolar organic compound
  • Organic oxoazanium
  • Carboxylic acid derivative
  • Carboxylic acid amide
  • Hydrocarbon derivative
  • Organic salt
  • Organooxygen compound
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Imine
  • Carbonyl group
  • Organic zwitterion
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationClonazepam is used as an anticonvulsant in the treatment of the Lennox-Gastaut syndrome (petit mal variant), akinetic and myoclonic seizures. It can also be used for the treatment of panic disorders.
PharmacodynamicsClonazepam, a benzodiazepine, is used primarily as an anticonvulsant in the treatment of absence seizures, petit mal variant seizures (Lennox-Gastaut syndrome), akinetic and myoclonic seizures, and nocturnal myoclonus. It enhances the activity of gamma aminobutyric acid (GABA), which is a major inhibitory neurotransmitter in the central nervous system. In animals, convulsions are antagonized occurs following administration of clonazepam. In humans, clonazepam suppresses the spike and wave discharge in absence seizures (petit mal) and decreases the frequency, amplitude, duration, and spread of discharge in minor motor seizures.
Mechanism of actionAllosteric interactions between central benzodiazepine receptors and gamma-aminobutyric acid (GABA) receptors potentiate the effects of GABA. As GABA is an inhibitory neurotransmitter, this results in increased inhibition of the ascending reticular activating system. Benzodiazepines, in this way, block the cortical and limbic arousal that occurs following stimulation of the reticular pathways.
Related Articles
AbsorptionClonazepam is rapidly and completely absorbed after oral administration. The absolute bioavailability of clonazepam is about 90%. Cmax, oral administration = 1 -4 hours.
Volume of distributionNot Available
Protein binding85% bound to plasma proteins.
Metabolism

Hepatic (cytochrome P450, including CYP3A). Biotransformation occurs mainly by reduction of the 7-nitro group to the 4-amino derivative. This derivative can be acetylated, hydroxylated, and glucuronidated.

Route of eliminationClonazepam is highly metabolized, with less than 2% unchanged clonazepam being excreted in the urine. Metabolites of Klonopin are excreted by the kidneys. Clonazepam also undergoes acetylation via NAT2.
Half life30-40 hours
ClearanceNot Available
ToxicitySomnolence, confusion, coma, and diminished reflexes. The most commonly reported adverse event when clonazepam is used for seizure disorders is CNS depression. LD50, oral, rats = >15000 mg/kg.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9946
Blood Brain Barrier+0.9718
Caco-2 permeable+0.5313
P-glycoprotein substrateSubstrate0.5594
P-glycoprotein inhibitor INon-inhibitor0.8474
P-glycoprotein inhibitor IINon-inhibitor0.9157
Renal organic cation transporterNon-inhibitor0.8179
CYP450 2C9 substrateNon-substrate0.7777
CYP450 2D6 substrateNon-substrate0.8934
CYP450 3A4 substrateSubstrate0.7295
CYP450 1A2 substrateInhibitor0.7646
CYP450 2C9 inhibitorInhibitor0.5213
CYP450 2D6 inhibitorNon-inhibitor0.8271
CYP450 2C19 inhibitorInhibitor0.7441
CYP450 3A4 inhibitorInhibitor0.5565
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.7255
Ames testNon AMES toxic0.6778
CarcinogenicityNon-carcinogens0.6417
BiodegradationNot ready biodegradable1.0
Rat acute toxicity1.6422 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9821
hERG inhibition (predictor II)Non-inhibitor0.8734
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Tabletoral.5 mg
Tabletoral1.0 mg
Tabletoral2.0 mg
Tablet, orally disintegratingoral.125 mg/1
Tablet, orally disintegratingoral.25 mg/1
Tablet, orally disintegratingoral.5 mg/1
Tablet, orally disintegratingoral1 mg/1
Tablet, orally disintegratingoral2 mg/1
Tabletoral.5 mg/1
Tabletoral1 mg/1
Tabletoral2 mg/1
Tabletoral0.5 mg
Tabletoral1 mg
Tabletoral2 mg
Tabletoral0.25 mg
Prices
Unit descriptionCostUnit
Klonopin 2 mg tablet2.85USD tablet
Klonopin 1 mg tablet2.17USD tablet
Klonopin 0.5 mg tablet1.91USD tablet
ClonazePAM ODT 2 mg Dispersible Tablet1.67USD dispersible tablet
ClonazePAM ODT 0.25 mg Dispersible Tablet1.22USD dispersible tablet
ClonazePAM ODT 0.5 mg Dispersible Tablet1.18USD dispersible tablet
ClonazePAM ODT 0.125 mg Dispersible Tablet1.17USD dispersible tablet
ClonazePAM ODT 1 mg Dispersible Tablet1.1USD dispersible tablet
Clonazepam 2 mg tablet0.81USD tablet
Clonazepam 1 mg tablet0.63USD tablet
Clonazepam 0.5 mg tablet0.61USD tablet
Rivotril 2 mg Tablet0.38USD tablet
Rivotril 0.5 mg Tablet0.22USD tablet
Apo-Clonazepam 2 mg Tablet0.21USD tablet
Co Clonazepam 2 mg Tablet0.21USD tablet
Mylan-Clonazepam 2 mg Tablet0.21USD tablet
Novo-Clonazepam 2 mg Tablet0.21USD tablet
Phl-Clonazepam 2 mg Tablet0.21USD tablet
Pms-Clonazepam 2 mg Tablet0.21USD tablet
Ratio-Clonazepam 2 mg Tablet0.21USD tablet
Sandoz Clonazepam 2 mg Tablet0.21USD tablet
Co Clonazepam 1 mg Tablet0.19USD tablet
Phl-Clonazepam 1 mg Tablet0.19USD tablet
Pms-Clonazepam 1 mg Tablet0.19USD tablet
Sandoz Clonazepam 1 mg Tablet0.19USD tablet
Apo-Clonazepam 0.5 mg Tablet0.12USD tablet
Co Clonazepam 0.5 mg Tablet0.12USD tablet
Mylan-Clonazepam 0.5 mg Tablet0.12USD tablet
Novo-Clonazepam 0.5 mg Tablet0.12USD tablet
Phl-Clonazepam 0.5 mg Tablet0.12USD tablet
Phl-Clonazepam-R 0.5 mg Tablet0.12USD tablet
Pms-Clonazepam 0.5 mg Tablet0.12USD tablet
Pms-Clonazepam-R 0.5 mg Tablet0.12USD tablet
Ratio-Clonazepam 0.5 mg Tablet0.12USD tablet
Sandoz Clonazepam 0.5 mg Tablet0.12USD tablet
Pms-Clonazepam 0.25 mg Tablet0.07USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point238-240Kariss, J. and Newmark, H.L.; US. Patents 3,116,203; December 31, 1963; and 3,123,529; March 3, 1964; both assigned to Hoffmann-LaRoche, Inc. Keller, O., Steiger, N. and Sternbach, L.H.; U S . Patents 3,121,114; February 11, 1964; and 3,203890; August 31, 1965; both assigned to Hoffmann-LaRoche, Inc. Focella, A. and Rachlin, A.I.; U.S. Patent 3,335,181; August 8, 1967; assigned to Hoffmann- LaRoche. Inc.
water solubility100 mg/L (at 25 °C)MERCK INDEX (1996)
logP2.41HANSCH,C ET AL. (1995)
Predicted Properties
PropertyValueSource
Water Solubility0.0106 mg/mLALOGPS
logP2.76ALOGPS
logP3.15ChemAxon
logS-4.5ALOGPS
pKa (Strongest Acidic)11.89ChemAxon
pKa (Strongest Basic)1.86ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area87.28 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity84.02 m3·mol-1ChemAxon
Polarizability29.59 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
MSMass Spectrum (Electron Ionization)splash10-02a9-2492000000-109e2626e8a128b9e433View in MoNA
References
Synthesis Reference

Kariss, J. and Newmark, H.L.; US. Patents 3,116,203; December 31, 1963; and 3,123,529; March 3, 1964; both assigned to Hoffmann-LaRoche, Inc.
Keller, O., Steiger, N. and Sternbach, L.H.; U S . Patents 3,121,114; February 11, 1964; and 3,203890; August 31, 1965; both assigned to Hoffmann-LaRoche, Inc.
Focella, A. and Rachlin, A.I.; U.S. Patent 3,335,181; August 8, 1967; assigned to Hoffmann- LaRoche. Inc.

General References
  1. Dreifuss FE, Penry JK, Rose SW, Kupferberg HJ, Dyken P, Sato S: Serum clonazepam concentrations in children with absence seizures. Neurology. 1975 Mar;25(3):255-8. [PubMed:1089913 ]
  2. Robertson MD, Drummer OH: Postmortem drug metabolism by bacteria. J Forensic Sci. 1995 May;40(3):382-6. [PubMed:7782744 ]
  3. Rosen GM, Turner MJ 3rd: Synthesis of spin traps specific for hydroxyl radical. J Med Chem. 1988 Feb;31(2):428-32. [PubMed:2828624 ]
  4. Rosen GM, Demos HA, Rauckman EJ: Not all aromatic nitro compounds form free radicals. Toxicol Lett. 1984 Aug;22(2):145-52. [PubMed:6089382 ]
  5. Earley JV, Fryer RI, Ning RY: Quinazolines and 1,4-benzodiazepines. LXXXIX: Haptens useful in benzodiazepine immunoassay development. J Pharm Sci. 1979 Jul;68(7):845-50. [PubMed:458601 ]
External Links
ATC CodesN03AE01
AHFS Codes
  • 28:12.08
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (74.3 KB)
Interactions
Drug Interactions
Drug
7-NitroindazoleThe risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with Clonazepam.
AcepromazineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Clonazepam.
AceprometazineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Clonazepam.
adipiplonThe risk or severity of adverse effects can be increased when adipiplon is combined with Clonazepam.
AgomelatineThe risk or severity of adverse effects can be increased when Agomelatine is combined with Clonazepam.
AlfaxaloneThe risk or severity of adverse effects can be increased when Alfaxalone is combined with Clonazepam.
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Clonazepam.
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Clonazepam.
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Clonazepam.
AminophyllineThe therapeutic efficacy of Clonazepam can be decreased when used in combination with Aminophylline.
AmiodaroneThe metabolism of Clonazepam can be decreased when combined with Amiodarone.
AmisulprideThe risk or severity of adverse effects can be increased when Amisulpride is combined with Clonazepam.
AmitriptylineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Clonazepam.
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Clonazepam.
AmoxapineThe risk or severity of adverse effects can be increased when Clonazepam is combined with Amoxapine.
AmperozideThe risk or severity of adverse effects can be increased when Amperozide is combined with Clonazepam.
AprepitantThe serum concentration of Clonazepam can be increased when it is combined with Aprepitant.
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Clonazepam.
ArticaineThe risk or severity of adverse effects can be increased when Articaine is combined with Clonazepam.
AsenapineThe risk or severity of adverse effects can be increased when Asenapine is combined with Clonazepam.
AtazanavirThe metabolism of Clonazepam can be decreased when combined with Atazanavir.
AtomoxetineThe metabolism of Clonazepam can be decreased when combined with Atomoxetine.
AzaperoneThe risk or severity of adverse effects can be increased when Azaperone is combined with Clonazepam.
AzelastineClonazepam may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
AzelastineThe risk or severity of adverse effects can be increased when Azelastine is combined with Clonazepam.
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Clonazepam.
BarbitalThe risk or severity of adverse effects can be increased when Barbital is combined with Clonazepam.
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Clonazepam.
Benzyl alcoholThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Clonazepam.
BexaroteneThe serum concentration of Clonazepam can be decreased when it is combined with Bexarotene.
BoceprevirThe metabolism of Clonazepam can be decreased when combined with Boceprevir.
BortezomibThe metabolism of Clonazepam can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Clonazepam can be decreased when it is combined with Bosentan.
BrexpiprazoleThe risk or severity of adverse effects can be increased when Clonazepam is combined with Brexpiprazole.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Clonazepam.
BrimonidineThe risk or severity of adverse effects can be increased when Clonazepam is combined with Brimonidine.
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Clonazepam.
BrompheniramineThe risk or severity of adverse effects can be increased when Brompheniramine is combined with Clonazepam.
BrotizolamThe risk or severity of adverse effects can be increased when Brotizolam is combined with Clonazepam.
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Clonazepam.
BuprenorphineThe risk or severity of adverse effects can be increased when Buprenorphine is combined with Clonazepam.
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Clonazepam.
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Clonazepam.
ButacaineThe risk or severity of adverse effects can be increased when Butacaine is combined with Clonazepam.
ButalbitalThe risk or severity of adverse effects can be increased when Butalbital is combined with Clonazepam.
ButambenThe risk or severity of adverse effects can be increased when Butamben is combined with Clonazepam.
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Clonazepam.
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Clonazepam.
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Clonazepam.
CarbinoxamineThe risk or severity of adverse effects can be increased when Carbinoxamine is combined with Clonazepam.
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Clonazepam.
CarisoprodolThe risk or severity of adverse effects can be increased when Carisoprodol is combined with Clonazepam.
CeritinibThe serum concentration of Clonazepam can be increased when it is combined with Ceritinib.
CetirizineThe risk or severity of adverse effects can be increased when Cetirizine is combined with Clonazepam.
Chloral hydrateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Clonazepam.
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Clonazepam.
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Clonazepam.
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Clonazepam.
ChlorphenamineThe risk or severity of adverse effects can be increased when Clonazepam is combined with Chlorphenamine.
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with Clonazepam.
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Clonazepam.
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Clonazepam.
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Clonazepam.
CitalopramThe risk or severity of adverse effects can be increased when Clonazepam is combined with Citalopram.
ClarithromycinThe metabolism of Clonazepam can be decreased when combined with Clarithromycin.
ClemastineThe metabolism of Clonazepam can be decreased when combined with Clemastine.
ClemastineThe risk or severity of adverse effects can be increased when Clonazepam is combined with Clemastine.
ClidiniumThe risk or severity of adverse effects can be increased when Clidinium is combined with Clonazepam.
ClobazamThe risk or severity of adverse effects can be increased when Clobazam is combined with Clonazepam.
clomethiazoleThe risk or severity of adverse effects can be increased when clomethiazole is combined with Clonazepam.
ClomipramineThe risk or severity of adverse effects can be increased when Clonazepam is combined with Clomipramine.
ClonidineThe risk or severity of adverse effects can be increased when Clonidine is combined with Clonazepam.
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Clonazepam.
ClotrimazoleThe metabolism of Clonazepam can be decreased when combined with Clotrimazole.
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Clonazepam.
CobicistatThe serum concentration of Clonazepam can be increased when it is combined with Cobicistat.
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Clonazepam.
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Clonazepam.
ConivaptanThe serum concentration of Clonazepam can be increased when it is combined with Conivaptan.
CosyntropinCosyntropin may increase the hepatotoxic activities of Clonazepam.
CrizotinibThe metabolism of Clonazepam can be decreased when combined with Crizotinib.
CyclizineThe risk or severity of adverse effects can be increased when Clonazepam is combined with Cyclizine.
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Clonazepam.
CyclosporineThe metabolism of Clonazepam can be decreased when combined with Cyclosporine.
CyproheptadineThe risk or severity of adverse effects can be increased when Cyproheptadine is combined with Clonazepam.
DabrafenibThe serum concentration of Clonazepam can be decreased when it is combined with Dabrafenib.
DantroleneThe risk or severity of adverse effects can be increased when Clonazepam is combined with Dantrolene.
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Clonazepam.
DapoxetineThe risk or severity of adverse effects can be increased when Clonazepam is combined with Dapoxetine.
DarunavirThe metabolism of Clonazepam can be decreased when combined with Darunavir.
DasatinibThe serum concentration of Clonazepam can be increased when it is combined with Dasatinib.
DeferasiroxThe serum concentration of Clonazepam can be decreased when it is combined with Deferasirox.
DelavirdineThe metabolism of Clonazepam can be decreased when combined with Delavirdine.
deramciclaneThe risk or severity of adverse effects can be increased when deramciclane is combined with Clonazepam.
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Clonazepam.
DesipramineThe risk or severity of adverse effects can be increased when Clonazepam is combined with Desipramine.
DesloratadineThe risk or severity of adverse effects can be increased when Desloratadine is combined with Clonazepam.
DetomidineThe risk or severity of adverse effects can be increased when Detomidine is combined with Clonazepam.
DexamethasoneThe serum concentration of Clonazepam can be decreased when it is combined with Dexamethasone.
DexbrompheniramineThe risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Clonazepam.
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Clonazepam.
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Clonazepam.
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Clonazepam.
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Clonazepam.
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Clonazepam.
DifenoxinThe risk or severity of adverse effects can be increased when Clonazepam is combined with Difenoxin.
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Clonazepam.
DihydroergotamineThe metabolism of Clonazepam can be decreased when combined with Dihydroergotamine.
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Clonazepam.
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with Clonazepam.
DiltiazemThe metabolism of Clonazepam can be decreased when combined with Diltiazem.
DimenhydrinateThe risk or severity of adverse effects can be increased when Dimenhydrinate is combined with Clonazepam.
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Clonazepam.
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Clonazepam.
DoramectinThe risk or severity of adverse effects can be increased when Doramectin is combined with Clonazepam.
DoxepinThe risk or severity of adverse effects can be increased when Clonazepam is combined with Doxepin.
DoxycyclineThe metabolism of Clonazepam can be decreased when combined with Doxycycline.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Clonazepam.
DoxylamineThe risk or severity of adverse effects can be increased when Clonazepam is combined with Doxylamine.
DPDPEThe risk or severity of adverse effects can be increased when DPDPE is combined with Clonazepam.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Clonazepam.
DronedaroneThe metabolism of Clonazepam can be decreased when combined with Dronedarone.
DroperidolThe risk or severity of adverse effects can be increased when Droperidol is combined with Clonazepam.
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Clonazepam.
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Clonazepam.
DyphyllineThe therapeutic efficacy of Clonazepam can be decreased when used in combination with Dyphylline.
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Clonazepam.
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when ECGONINE METHYL ESTER is combined with Clonazepam.
EfavirenzThe serum concentration of Clonazepam can be decreased when it is combined with Efavirenz.
EfavirenzThe risk or severity of adverse effects can be increased when Clonazepam is combined with Efavirenz.
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Clonazepam.
EntacaponeThe risk or severity of adverse effects can be increased when Entacapone is combined with Clonazepam.
EnzalutamideThe serum concentration of Clonazepam can be decreased when it is combined with Enzalutamide.
ErythromycinThe metabolism of Clonazepam can be decreased when combined with Erythromycin.
EscitalopramThe risk or severity of adverse effects can be increased when Clonazepam is combined with Escitalopram.
Eslicarbazepine acetateThe serum concentration of Clonazepam can be decreased when it is combined with Eslicarbazepine acetate.
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Clonazepam.
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Clonazepam.
EthanolClonazepam may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
EthanolThe risk or severity of adverse effects can be increased when Ethanol is combined with Clonazepam.
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Clonazepam.
EthosuximideThe risk or severity of adverse effects can be increased when Ethosuximide is combined with Clonazepam.
EthotoinThe risk or severity of adverse effects can be increased when Ethotoin is combined with Clonazepam.
Ethyl carbamateThe risk or severity of adverse effects can be increased when Ethyl carbamate is combined with Clonazepam.
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Clonazepam.
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Clonazepam.
EtidocaineThe risk or severity of adverse effects can be increased when Etidocaine is combined with Clonazepam.
EtifoxineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Clonazepam.
EtizolamThe risk or severity of adverse effects can be increased when Etizolam is combined with Clonazepam.
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Clonazepam.
EtoperidoneThe risk or severity of adverse effects can be increased when Clonazepam is combined with Etoperidone.
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Clonazepam.
EtravirineThe serum concentration of Clonazepam can be decreased when it is combined with Etravirine.
EzogabineThe risk or severity of adverse effects can be increased when Clonazepam is combined with Ezogabine.
FelbamateThe risk or severity of adverse effects can be increased when Felbamate is combined with Clonazepam.
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Clonazepam.
FenfluramineThe risk or severity of adverse effects can be increased when Clonazepam is combined with Fenfluramine.
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Clonazepam.
FexofenadineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Clonazepam.
FlibanserinThe risk or severity of adverse effects can be increased when Clonazepam is combined with Flibanserin.
FluconazoleThe metabolism of Clonazepam can be decreased when combined with Fluconazole.
FludiazepamThe risk or severity of adverse effects can be increased when Fludiazepam is combined with Clonazepam.
FlunarizineThe risk or severity of adverse effects can be increased when Clonazepam is combined with Flunarizine.
FlunitrazepamThe risk or severity of adverse effects can be increased when Flunitrazepam is combined with Clonazepam.
FluoxetineThe risk or severity of adverse effects can be increased when Clonazepam is combined with Fluoxetine.
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Clonazepam.
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Clonazepam.
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Clonazepam.
FluspirileneThe risk or severity of adverse effects can be increased when Fluspirilene is combined with Clonazepam.
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Clonazepam.
FluvoxamineThe risk or severity of adverse effects can be increased when Clonazepam is combined with Fluvoxamine.
FluvoxamineThe metabolism of Clonazepam can be decreased when combined with Fluvoxamine.
FosamprenavirThe metabolism of Clonazepam can be decreased when combined with Fosamprenavir.
FosaprepitantThe serum concentration of Clonazepam can be increased when it is combined with Fosaprepitant.
FosphenytoinThe serum concentration of Fosphenytoin can be increased when it is combined with Clonazepam.
FosphenytoinThe risk or severity of adverse effects can be increased when Fosphenytoin is combined with Clonazepam.
FospropofolThe risk or severity of adverse effects can be increased when Fospropofol is combined with Clonazepam.
Fusidic AcidThe serum concentration of Clonazepam can be increased when it is combined with Fusidic Acid.
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Clonazepam.
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Clonazepam is combined with gabapentin enacarbil.
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Clonazepam.
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Clonazepam.
GuanfacineThe risk or severity of adverse effects can be increased when Guanfacine is combined with Clonazepam.
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Clonazepam.
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Clonazepam.
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Clonazepam.
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Clonazepam.
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Clonazepam.
HydrocodoneThe risk or severity of adverse effects can be increased when Hydrocodone is combined with Clonazepam.
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Clonazepam.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Clonazepam.
HydroxyzineThe risk or severity of adverse effects can be increased when Clonazepam is combined with Hydroxyzine.
IdelalisibThe serum concentration of Clonazepam can be increased when it is combined with Idelalisib.
IloperidoneThe risk or severity of adverse effects can be increased when Clonazepam is combined with Iloperidone.
ImatinibThe metabolism of Clonazepam can be decreased when combined with Imatinib.
ImipramineThe risk or severity of adverse effects can be increased when Imipramine is combined with Clonazepam.
IndalpineThe risk or severity of adverse effects can be increased when Clonazepam is combined with Indalpine.
IndinavirThe metabolism of Clonazepam can be decreased when combined with Indinavir.
IsavuconazoniumThe metabolism of Clonazepam can be decreased when combined with Isavuconazonium.
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Clonazepam.
IsradipineThe metabolism of Clonazepam can be decreased when combined with Isradipine.
ItraconazoleThe metabolism of Clonazepam can be decreased when combined with Itraconazole.
IvacaftorThe serum concentration of Clonazepam can be increased when it is combined with Ivacaftor.
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Clonazepam.
KetazolamThe risk or severity of adverse effects can be increased when Ketazolam is combined with Clonazepam.
KetobemidoneThe risk or severity of adverse effects can be increased when Ketobemidone is combined with Clonazepam.
KetoconazoleThe metabolism of Clonazepam can be decreased when combined with Ketoconazole.
LamotrigineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Clonazepam.
LevetiracetamThe risk or severity of adverse effects can be increased when Clonazepam is combined with Levetiracetam.
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Clonazepam.
LevocabastineThe risk or severity of adverse effects can be increased when Clonazepam is combined with Levocabastine.
LevocetirizineThe risk or severity of adverse effects can be increased when Clonazepam is combined with Levocetirizine.
LevodopaThe risk or severity of adverse effects can be increased when Clonazepam is combined with Levodopa.
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Clonazepam.
LevomilnacipranThe risk or severity of adverse effects can be increased when Clonazepam is combined with Levomilnacipran.
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Clonazepam.
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Clonazepam.
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Clonazepam.
LofentanilThe risk or severity of adverse effects can be increased when Lofentanil is combined with Clonazepam.
LopinavirThe metabolism of Clonazepam can be decreased when combined with Lopinavir.
LoratadineThe risk or severity of adverse effects can be increased when Loratadine is combined with Clonazepam.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Clonazepam.
LovastatinThe metabolism of Clonazepam can be decreased when combined with Lovastatin.
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Clonazepam.
Lu AA21004The risk or severity of adverse effects can be increased when Clonazepam is combined with Lu AA21004.
LuliconazoleThe serum concentration of Clonazepam can be increased when it is combined with Luliconazole.
LurasidoneThe risk or severity of adverse effects can be increased when Lurasidone is combined with Clonazepam.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Clonazepam.
Magnesium SulfateThe risk or severity of adverse effects can be increased when Clonazepam is combined with Magnesium Sulfate.
MaprotilineThe risk or severity of adverse effects can be increased when Maprotiline is combined with Clonazepam.
MeclizineThe risk or severity of adverse effects can be increased when Meclizine is combined with Clonazepam.
MedetomidineThe risk or severity of adverse effects can be increased when Medetomidine is combined with Clonazepam.
MefloquineThe therapeutic efficacy of Clonazepam can be decreased when used in combination with Mefloquine.
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Clonazepam.
MelperoneThe risk or severity of adverse effects can be increased when Melperone is combined with Clonazepam.
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Clonazepam.
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Clonazepam.
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Clonazepam.
MetaxaloneThe risk or severity of adverse effects can be increased when Metaxalone is combined with Clonazepam.
MethadoneClonazepam may increase the central nervous system depressant (CNS depressant) activities of Methadone.
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Clonazepam.
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Clonazepam.
MethapyrileneThe risk or severity of adverse effects can be increased when Methapyrilene is combined with Clonazepam.
MethaqualoneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Clonazepam.
MethocarbamolThe risk or severity of adverse effects can be increased when Methocarbamol is combined with Clonazepam.
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Clonazepam.
MethotrimeprazineThe risk or severity of adverse effects can be increased when Methotrimeprazine is combined with Clonazepam.
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Clonazepam.
MethsuximideThe risk or severity of adverse effects can be increased when Clonazepam is combined with Methsuximide.
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Clonazepam.
MetyrosineClonazepam may increase the sedative activities of Metyrosine.
MianserinThe therapeutic efficacy of Clonazepam can be decreased when used in combination with Mianserin.
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Clonazepam.
MifepristoneThe metabolism of Clonazepam can be decreased when combined with Mifepristone.
MilnacipranThe risk or severity of adverse effects can be increased when Clonazepam is combined with Milnacipran.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Clonazepam.
MirtazapineClonazepam may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MirtazapineThe risk or severity of adverse effects can be increased when Mirtazapine is combined with Clonazepam.
MitotaneThe serum concentration of Clonazepam can be decreased when it is combined with Mitotane.
ModafinilThe serum concentration of Clonazepam can be decreased when it is combined with Modafinil.
MolindoneThe risk or severity of adverse effects can be increased when Molindone is combined with Clonazepam.
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Clonazepam.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Clonazepam.
NabiloneThe risk or severity of adverse effects can be increased when Clonazepam is combined with Nabilone.
NafcillinThe serum concentration of Clonazepam can be decreased when it is combined with Nafcillin.
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Clonazepam.
NefazodoneThe metabolism of Clonazepam can be decreased when combined with Nefazodone.
NelfinavirThe metabolism of Clonazepam can be decreased when combined with Nelfinavir.
NetupitantThe serum concentration of Clonazepam can be increased when it is combined with Netupitant.
NevirapineThe metabolism of Clonazepam can be decreased when combined with Nevirapine.
NilotinibThe metabolism of Clonazepam can be decreased when combined with Nilotinib.
NitrazepamThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Clonazepam.
Nitrous oxideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Clonazepam.
NormethadoneThe risk or severity of adverse effects can be increased when Normethadone is combined with Clonazepam.
NortriptylineThe risk or severity of adverse effects can be increased when Nortriptyline is combined with Clonazepam.
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Clonazepam.
OlaparibThe metabolism of Clonazepam can be decreased when combined with Olaparib.
OlopatadineThe risk or severity of adverse effects can be increased when Olopatadine is combined with Clonazepam.
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Clonazepam.
OpiumThe risk or severity of adverse effects can be increased when Opium is combined with Clonazepam.
OrlistatThe serum concentration of Clonazepam can be decreased when it is combined with Orlistat.
OrphenadrineClonazepam may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
OrphenadrineThe risk or severity of adverse effects can be increased when Orphenadrine is combined with Clonazepam.
OsanetantThe risk or severity of adverse effects can be increased when Osanetant is combined with Clonazepam.
OsimertinibThe serum concentration of Clonazepam can be increased when it is combined with Osimertinib.
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Clonazepam.
OxprenololThe risk or severity of adverse effects can be increased when Oxprenolol is combined with Clonazepam.
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Clonazepam.
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Clonazepam.
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Clonazepam.
PalbociclibThe serum concentration of Clonazepam can be increased when it is combined with Palbociclib.
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Clonazepam.
ParaldehydeClonazepam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParaldehydeThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Clonazepam.
ParoxetineThe risk or severity of adverse effects can be increased when Clonazepam is combined with Paroxetine.
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Clonazepam.
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Clonazepam.
PerampanelThe risk or severity of adverse effects can be increased when Clonazepam is combined with Perampanel.
PerospironeThe risk or severity of adverse effects can be increased when Perospirone is combined with Clonazepam.
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Clonazepam.
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Clonazepam.
PhenobarbitalThe risk or severity of adverse effects can be increased when Phenobarbital is combined with Clonazepam.
PhenoxyethanolThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Clonazepam.
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Clonazepam.
PhenytoinThe risk or severity of adverse effects can be increased when Phenytoin is combined with Clonazepam.
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Clonazepam.
PipamperoneThe risk or severity of adverse effects can be increased when Pipamperone is combined with Clonazepam.
PipotiazineThe risk or severity of adverse effects can be increased when Clonazepam is combined with Pipotiazine.
PizotifenThe risk or severity of adverse effects can be increased when Clonazepam is combined with Pizotifen.
PomalidomideThe risk or severity of adverse effects can be increased when Clonazepam is combined with Pomalidomide.
PosaconazoleThe metabolism of Clonazepam can be decreased when combined with Posaconazole.
PramipexoleClonazepam may increase the sedative activities of Pramipexole.
PramocaineThe risk or severity of adverse effects can be increased when Pramocaine is combined with Clonazepam.
PrazepamThe risk or severity of adverse effects can be increased when Prazepam is combined with Clonazepam.
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Clonazepam.
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Clonazepam.
PrimidoneThe risk or severity of adverse effects can be increased when Primidone is combined with Clonazepam.
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Clonazepam.
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Clonazepam.
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Clonazepam.
PromethazineThe risk or severity of adverse effects can be increased when Clonazepam is combined with Promethazine.
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Clonazepam.
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Clonazepam.
PropoxycaineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Clonazepam.
ProtriptylineThe risk or severity of adverse effects can be increased when Protriptyline is combined with Clonazepam.
PSD502The risk or severity of adverse effects can be increased when PSD502 is combined with Clonazepam.
QuazepamThe risk or severity of adverse effects can be increased when Quazepam is combined with Clonazepam.
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Clonazepam.
RamelteonThe risk or severity of adverse effects can be increased when Ramelteon is combined with Clonazepam.
RanolazineThe metabolism of Clonazepam can be decreased when combined with Ranolazine.
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Clonazepam.
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Clonazepam.
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Clonazepam.
RifabutinThe metabolism of Clonazepam can be increased when combined with Rifabutin.
RifampicinThe metabolism of Clonazepam can be increased when combined with Rifampicin.
RifapentineThe metabolism of Clonazepam can be increased when combined with Rifapentine.
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Clonazepam.
RitonavirThe metabolism of Clonazepam can be decreased when combined with Ritonavir.
RomifidineThe risk or severity of adverse effects can be increased when Romifidine is combined with Clonazepam.
RopiniroleClonazepam may increase the sedative activities of Ropinirole.
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Clonazepam.
RotigotineClonazepam may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Clonazepam.
S-EthylisothioureaThe risk or severity of adverse effects can be increased when S-Ethylisothiourea is combined with Clonazepam.
SaquinavirThe metabolism of Clonazepam can be decreased when combined with Saquinavir.
ScopolamineThe risk or severity of adverse effects can be increased when Scopolamine is combined with Clonazepam.
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Clonazepam.
SertindoleThe risk or severity of adverse effects can be increased when Sertindole is combined with Clonazepam.
SertralineThe risk or severity of adverse effects can be increased when Clonazepam is combined with Sertraline.
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Clonazepam.
SildenafilThe metabolism of Clonazepam can be decreased when combined with Sildenafil.
SiltuximabThe serum concentration of Clonazepam can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Clonazepam can be increased when it is combined with Simeprevir.
Sodium oxybateClonazepam may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Sodium oxybateThe risk or severity of adverse effects can be increased when Sodium oxybate is combined with Clonazepam.
St. John's WortThe serum concentration of Clonazepam can be decreased when it is combined with St. John's Wort.
StiripentolThe risk or severity of adverse effects can be increased when Clonazepam is combined with Stiripentol.
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Clonazepam.
SulfisoxazoleThe metabolism of Clonazepam can be decreased when combined with Sulfisoxazole.
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Clonazepam.
SuvorexantThe risk or severity of adverse effects can be increased when Clonazepam is combined with Suvorexant.
TapentadolThe risk or severity of adverse effects can be increased when Clonazepam is combined with Tapentadol.
TasimelteonThe risk or severity of adverse effects can be increased when Clonazepam is combined with Tasimelteon.
TeduglutideThe serum concentration of Clonazepam can be increased when it is combined with Teduglutide.
TelaprevirThe metabolism of Clonazepam can be decreased when combined with Telaprevir.
TelithromycinThe metabolism of Clonazepam can be decreased when combined with Telithromycin.
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Clonazepam.
TetrabenazineThe risk or severity of adverse effects can be increased when Clonazepam is combined with Tetrabenazine.
TetracaineThe risk or severity of adverse effects can be increased when Tetracaine is combined with Clonazepam.
TetrodotoxinThe risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Clonazepam.
ThalidomideClonazepam may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
ThalidomideThe risk or severity of adverse effects can be increased when Thalidomide is combined with Clonazepam.
TheophyllineThe therapeutic efficacy of Clonazepam can be decreased when used in combination with Theophylline.
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Clonazepam.
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Clonazepam.
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Clonazepam.
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with Clonazepam.
TiagabineThe risk or severity of adverse effects can be increased when Tiagabine is combined with Clonazepam.
TiclopidineThe metabolism of Clonazepam can be decreased when combined with Ticlopidine.
TiletamineThe risk or severity of adverse effects can be increased when Tiletamine is combined with Clonazepam.
TizanidineThe risk or severity of adverse effects can be increased when Tizanidine is combined with Clonazepam.
TocilizumabThe serum concentration of Clonazepam can be decreased when it is combined with Tocilizumab.
TolcaponeThe risk or severity of adverse effects can be increased when Tolcapone is combined with Clonazepam.
TopiramateThe risk or severity of adverse effects can be increased when Topiramate is combined with Clonazepam.
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Clonazepam.
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Trans-2-Phenylcyclopropylamine is combined with Clonazepam.
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Clonazepam.
TrazodoneThe risk or severity of adverse effects can be increased when Clonazepam is combined with Trazodone.
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Clonazepam.
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Clonazepam.
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Clonazepam.
TrimipramineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Clonazepam.
TriprolidineThe risk or severity of adverse effects can be increased when Triprolidine is combined with Clonazepam.
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Clonazepam.
VenlafaxineThe metabolism of Clonazepam can be decreased when combined with Venlafaxine.
VerapamilThe metabolism of Clonazepam can be decreased when combined with Verapamil.
VigabatrinVigabatrin may increase the central nervous system depressant (CNS depressant) activities of Clonazepam.
VigabatrinThe risk or severity of adverse effects can be increased when Clonazepam is combined with Vigabatrin.
VilazodoneThe risk or severity of adverse effects can be increased when Clonazepam is combined with Vilazodone.
VoriconazoleThe metabolism of Clonazepam can be decreased when combined with Voriconazole.
VortioxetineThe risk or severity of adverse effects can be increased when Clonazepam is combined with Vortioxetine.
XylazineThe risk or severity of adverse effects can be increased when Xylazine is combined with Clonazepam.
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Clonazepam.
ZiconotideThe risk or severity of adverse effects can be increased when Clonazepam is combined with Ziconotide.
ZimelidineThe risk or severity of adverse effects can be increased when Clonazepam is combined with Zimelidine.
ZiprasidoneThe metabolism of Clonazepam can be decreased when combined with Ziprasidone.
ZiprasidoneThe risk or severity of adverse effects can be increased when Clonazepam is combined with Ziprasidone.
ZolazepamThe risk or severity of adverse effects can be increased when Zolazepam is combined with Clonazepam.
ZolpidemThe risk or severity of adverse effects can be increased when Zolpidem is combined with Clonazepam.
ZonisamideThe risk or severity of adverse effects can be increased when Zonisamide is combined with Clonazepam.
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Clonazepam.
ZotepineThe risk or severity of adverse effects can be increased when Zotepine is combined with Clonazepam.
ZuclopenthixolThe risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Clonazepam.
Food Interactions
  • Avoid alcohol.
  • Avoid excessive quantities of coffee or tea (Caffeine).
  • Take without regard to meals.

Targets

Kind
Protein group
Organism
Human
Pharmacological action
yes
Actions
positive allosteric modulator
General Function:
Inhibitory extracellular ligand-gated ion channel activity
Specific Function:
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity).
Components:
NameUniProt IDDetails
Gamma-aminobutyric acid receptor subunit alpha-1P14867 Details
Gamma-aminobutyric acid receptor subunit alpha-2P47869 Details
Gamma-aminobutyric acid receptor subunit alpha-3P34903 Details
Gamma-aminobutyric acid receptor subunit alpha-4P48169 Details
Gamma-aminobutyric acid receptor subunit alpha-5P31644 Details
Gamma-aminobutyric acid receptor subunit alpha-6Q16445 Details
Gamma-aminobutyric acid receptor subunit beta-1P18505 Details
Gamma-aminobutyric acid receptor subunit beta-2P47870 Details
Gamma-aminobutyric acid receptor subunit beta-3P28472 Details
Gamma-aminobutyric acid receptor subunit deltaO14764 Details
Gamma-aminobutyric acid receptor subunit epsilonP78334 Details
Gamma-aminobutyric acid receptor subunit gamma-1Q8N1C3 Details
Gamma-aminobutyric acid receptor subunit gamma-2P18507 Details
Gamma-aminobutyric acid receptor subunit gamma-3Q99928 Details
Gamma-aminobutyric acid receptor subunit piO00591 Details
Gamma-aminobutyric acid receptor subunit thetaQ9UN88 Details
References
  1. Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. [PubMed:11752090 ]
  2. Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. doi: 10.1111/j.1600-0404.2008.01004.x. Epub 2008 Mar 31. [PubMed:18384456 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
other/unknown
General Function:
Cholesterol binding
Specific Function:
Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:24814875), but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benz...
Gene Name:
TSPO
Uniprot ID:
P30536
Molecular Weight:
18827.81 Da
References
  1. Carmel I, Fares FA, Leschiner S, Scherubl H, Weisinger G, Gavish M: Peripheral-type benzodiazepine receptors in the regulation of proliferation of MCF-7 human breast carcinoma cell line. Biochem Pharmacol. 1999 Jul 15;58(2):273-8. [PubMed:10423168 ]
  2. Bono F, Lamarche I, Prabonnaud V, Le Fur G, Herbert JM: Peripheral benzodiazepine receptor agonists exhibit potent antiapoptotic activities. Biochem Biophys Res Commun. 1999 Nov 19;265(2):457-61. [PubMed:10558889 ]
  3. Bolger GT, Abraham S, Oz N, Weissman BA: Interactions between peripheral-type benzodiazepine receptor ligands and an activator of voltage-operated calcium channels. Can J Physiol Pharmacol. 1990 Jan;68(1):40-5. [PubMed:1691678 ]
  4. Marano G, Massotti M, Spagnolo A, Carpi A: Enhancement of pharmacologically induced bronchoconstriction by Ro 5-4864. Eur J Pharmacol. 1990 Apr 10;179(1-2):237-40. [PubMed:2364987 ]
  5. Awad M, Gavish M: Solubilization of peripheral-type benzodiazepine binding sites from cat cerebral cortex. J Neurochem. 1989 Jun;52(6):1880-5. [PubMed:2723642 ]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Gene Name:
CYP2E1
Uniprot ID:
P05181
Molecular Weight:
56848.42 Da
References
  1. Tassaneeyakul W, Birkett DJ, Miners JO: Inhibition of human hepatic cytochrome P4502E1 by azole antifungals, CNS-active drugs and non-steroidal anti-inflammatory agents. Xenobiotica. 1998 Mar;28(3):293-301. [PubMed:9574817 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Arylamine n-acetyltransferase activity
Specific Function:
Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.
Gene Name:
NAT2
Uniprot ID:
P11245
Molecular Weight:
33542.235 Da
References
  1. Olivera M, Martinez C, Gervasini G, Carrillo JA, Ramos S, Benitez J, Garcia-Martin E, Agundez JA: Effect of common NAT2 variant alleles in the acetylation of the major clonazepam metabolite, 7-aminoclonazepam. Drug Metab Lett. 2007 Jan;1(1):3-5. [PubMed:19356010 ]
  2. Miller ME, Garland WA, Min BH, Ludwick BT, Ballard RH, Levy RH: Clonazepam acetylation in fast and slow acetylators. Clin Pharmacol Ther. 1981 Sep;30(3):343-7. [PubMed:7273597 ]

Carriers

Kind
Protein
Organism
Human
Pharmacological action
no
General Function:
Toxic substance binding
Specific Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
Gene Name:
ALB
Uniprot ID:
P02768
Molecular Weight:
69365.94 Da
References
  1. Pacifici GM, Viani A, Rizzo G, Carrai M, Rane A: Plasma protein binding of clonazepam in hepatic and renal insufficiency and after hemodialysis. Ther Drug Monit. 1987 Dec;9(4):369-73. [PubMed:3424402 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23