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targets (1)
for drugs
Identification
Name Magnesium
Accession Number DB01378
Type small molecule
Groups experimental
Description

Magnesium hydroxide is used primarily in “Milk of Magnesia”, a white aqueous, mildly alkaline suspension of magnesium hydroxide formulated at about 8%w/v. Milk of magnesia is primarily used to alleviate constipation, but can also be used to relieve indigestion and heartburn. When taken internally by mouth as a laxative, the osmotic force of the magnesia suspension acts to draw fluids from the body and to retain those already within the lumen of the intestine, serving to distend the bowel, thus stimulating nerves within the colon wall, inducing peristalsis and resulting in evacuation of colonic contents.
Structure Thumb
Download: MOL | SDF | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms Not Available
Brand names Not Available
Brand name mixtures Not Available
Categories Not Available
CAS number 7439-95-4
Weight Average: 24.305
Monoisotopic: 23.985041898
Chemical Formula Mg
InChI Key InChIKey=JLVVSXFLKOJNIY-UHFFFAOYSA-N
InChI
InChI=1S/Mg/q+2
Plain Text
IUPAC Name
magnesium(2+) ion
SMILES
[Mg++]
Plain Text
Mass Spec Not Available
Taxonomy
Kingdom Not Available
Classes Not Available
Substructures Not Available
Pharmacology
Indication Not Available
Pharmacodynamics Not Available
Mechanism of action Not Available
Absorption Not Available
Volume of distribution Not Available
Protein binding Not Available
Metabolism
Route of elimination Not Available
Half life Not Available
Clearance Not Available
Toxicity Not Available
Affected organisms Not Available
Pathways Not Available
Pharmacoeconomics
Manufacturers Not Available
Packagers
Dosage forms
Form Route Strength
Aerosol Oral
Capsule Oral
Liquid Intramuscular
Liquid Intravenous
Liquid Oral
Ointment Topical
Pellet Oral
Powder Oral
Solution Intramuscular
Solution Intravenous
Solution Oral
Solution / drops Oral
Suspension Oral
Syrup Oral
Tablet Oral
Prices Not Available
Patents Not Available
Properties
State solid
Melting point 651 oC
Experimental Properties Not Available
Predicted Properties
Property Value Source
water solubility ALOGPS
logP ALOGPS
logP -0.57 ChemAxon Molconvert
logS ALOGPS
pKa ChemAxon Molconvert
hydrogen acceptor count 0 ChemAxon Molconvert
hydrogen donor count 0 ChemAxon Molconvert
polar surface area 0.00 ChemAxon Molconvert
rotatable bond count 0 ChemAxon Molconvert
refractivity 0.00 ChemAxon Molconvert
polarizability 1.78 ChemAxon Molconvert
References
Synthesis Reference Not Available
General Reference Not Available
External Links
Resource Link
KEGG Compound C00305 Link_out
PubChem Compound 888 Link_out
PubChem Substance 46508750 Link_out
ChemSpider 865 Link_out
BindingDB 15 Link_out
ChEBI 25107 Link_out
ChEMBL 25107 Link_out
Therapeutic Targets Database DCL000876 Link_out
PharmGKB PA450287 Link_out
Drug Product Database 13838 Link_out
Wikipedia http://en.wikipedia.org/wiki/Magnesium Link_out
ATC Codes
  • A12CC08
  • B05XA11
  • A06AD03
  • B05XA10
  • A06AD19
  • A02AA04
  • A12CC09
  • A02AA01
  • A06AD02
  • A12CC10
  • A12CC01
  • A12CC04
  • B05CB03
  • A12CC07
  • G04BX01
  • A12CC03
  • A12CC02
  • A02AA03
  • A06AD04
  • A02AA02
  • A12CC05
  • A02AA05
  • A06AD01
  • C10AX07
  • A12CC06
  • A12CC30
  • D11AX05
  • V04CC02
  • B05XA05
AHFS Codes
  • 88:29.00*
  • 56:04.00
  • 84:24.00
  • 56:12.00
  • 28:12.92
  • 92:02.00*
  • 84:92.00
  • 28:08.04.24
  • 40:12.00
  • 40:34.00*
PDB Entries Not Available
FDA label Not Available
MSDS show (73.4 KB)
Interactions
Drug Interactions Not Available
Food Interactions Not Available
Targets

1. Sodium/potassium-transporting ATPase alpha-1 chain

Pharmacological action: unknown

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients

Organism class: human
UniProt ID: P05023 Link_out
Gene: ATP1A1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Buchachenko AL, Kuznetsov DA, Berdinskii VL: [New mechanisms of biological effects of electromagnetic fields] Biofizika. 2006 May-Jun;51(3):545-52. Pubmed
  2. Sirijovski N, Olsson U, Lundqvist J, Al-Karadaghi S, Willows RD, Hansson M: ATPase activity associated with the magnesium chelatase H-subunit of the chlorophyll biosynthetic pathway is an artefact. Biochem J. 2006 Dec 15;400(3):477-84. Pubmed
  3. Balasubramaniyan V, Nalini N: Leptin alters brain adenosine triphosphatase activity in ethanol-mediated neurotoxicity in mice. Singapore Med J. 2006 Oct;47(10):864-8. Pubmed
  4. Nogovitsina OR, Levitina EV: Neurological aspects of the clinical features, pathophysiology, and corrections of impairments in attention deficit hyperactivity disorder. Neurosci Behav Physiol. 2007 Mar;37(3):199-202. Pubmed
Comments
Drug created on July 06, 2007 14:30 / Updated on November 10, 2010 13:48

This project is supported by Genome Alberta & Genome Canada, a not-for-profit organization that is leading Canada's national genomics strategy with $600 million in funding from the federal government. This project is also supported in part by GenomeQuest, Inc., an enterprise genomic information company serving the life science community.