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Identification
NameMethadyl Acetate
Accession NumberDB01433
TypeSmall Molecule
GroupsApproved, Illicit
DescriptionA narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. [PubChem]
Structure
Thumb
Synonyms
Acetilmetadol
Acetylmethadol
Acetylmethadolum
Betamethadol
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNIIL59OC40KWJ
CAS number509-74-0
WeightAverage: 353.4977
Monoisotopic: 353.235479241
Chemical FormulaC23H31NO2
InChI KeyInChIKey=XBMIVRRWGCYBTQ-UHFFFAOYSA-N
InChI
InChI=1S/C23H31NO2/c1-6-22(26-19(3)25)23(17-18(2)24(4)5,20-13-9-7-10-14-20)21-15-11-8-12-16-21/h7-16,18,22H,6,17H2,1-5H3
IUPAC Name
6-(dimethylamino)-4,4-diphenylheptan-3-yl acetate
SMILES
CCC(OC(C)=O)C(CC(C)N(C)C)(C1=CC=CC=C1)C1=CC=CC=C1
Taxonomy
ClassificationNot classified
Pharmacology
IndicationUsed mainly in the treatment of narcotic dependence.
PharmacodynamicsMethadyl Acetate is a narcotic analgesic with a long onset and duration of action. The drug decreases a patients opioid use by preventing opioid withdrawal and in how it can mimic some of the effects of opioids.
Mechanism of actionMethadyl Acetate is primarily a mu-type opioid receptor agonist. It functions similarily to methadone.
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Methadyl Acetate Action PathwayDrug actionSMP00678
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9965
Blood Brain Barrier+0.9648
Caco-2 permeable+0.7459
P-glycoprotein substrateSubstrate0.5822
P-glycoprotein inhibitor IInhibitor0.8472
P-glycoprotein inhibitor IINon-inhibitor0.8897
Renal organic cation transporterNon-inhibitor0.6473
CYP450 2C9 substrateNon-substrate0.7976
CYP450 2D6 substrateNon-substrate0.8641
CYP450 3A4 substrateSubstrate0.6658
CYP450 1A2 substrateInhibitor0.5619
CYP450 2C9 inhibitorNon-inhibitor0.8153
CYP450 2D6 inhibitorInhibitor0.7123
CYP450 2C19 inhibitorNon-inhibitor0.7312
CYP450 3A4 inhibitorInhibitor0.5242
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.5811
Ames testNon AMES toxic0.9016
CarcinogenicityCarcinogens 0.7025
BiodegradationNot ready biodegradable0.9792
Rat acute toxicity3.3406 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9706
hERG inhibition (predictor II)Inhibitor0.7157
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
logP4.27HANSCH,C ET AL. (1995)
Predicted Properties
PropertyValueSource
Water Solubility0.00179 mg/mLALOGPS
logP4.78ALOGPS
logP4.88ChemAxon
logS-5.3ALOGPS
pKa (Strongest Basic)9.87ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area29.54 Å2ChemAxon
Rotatable Bond Count9ChemAxon
Refractivity117.86 m3·mol-1ChemAxon
Polarizability40.82 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesNot Available
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
Interactions
Drug Interactions
Drug
3,4-Methylenedioxyamphetamine3,4-Methylenedioxyamphetamine may increase the analgesic activities of Methadyl Acetate.
3,4-Methylenedioxymethamphetamine3,4-Methylenedioxymethamphetamine may increase the analgesic activities of Methadyl Acetate.
7-NitroindazoleThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with 7-Nitroindazole.
AcepromazineAcepromazine may increase the hypotensive activities of Methadyl Acetate.
AcepromazineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Acepromazine.
AceprometazineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Aceprometazine.
AcetazolamideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Acetazolamide.
AclidiniumThe risk or severity of adverse effects can be increased when Aclidinium is combined with Methadyl Acetate.
adipiplonThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with adipiplon.
AgomelatineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Agomelatine.
AlfaxaloneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Alfaxalone.
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Methadyl Acetate.
AlimemazineAlimemazine may increase the hypotensive activities of Methadyl Acetate.
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Alphacetylmethadol.
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Methadyl Acetate.
AlvimopanThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Alvimopan.
AmilorideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Amiloride.
AmisulprideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Amisulpride.
AmitriptylineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Amitriptyline.
Ammonium chlorideAmmonium chloride may increase the excretion rate of Methadyl Acetate which could result in a higher serum level.
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Methadyl Acetate.
AmoxapineMethadyl Acetate may increase the serotonergic activities of Amoxapine.
AmoxapineThe risk or severity of adverse effects can be increased when Amoxapine is combined with Methadyl Acetate.
AmperozideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Amperozide.
AmphetamineAmphetamine may increase the analgesic activities of Methadyl Acetate.
Anisotropine MethylbromideThe risk or severity of adverse effects can be increased when Anisotropine Methylbromide is combined with Methadyl Acetate.
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Methadyl Acetate.
ArticaineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Articaine.
AsenapineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Asenapine.
Atracurium besylateThe risk or severity of adverse effects can be increased when Atracurium besylate is combined with Methadyl Acetate.
AtropineThe risk or severity of adverse effects can be increased when Atropine is combined with Methadyl Acetate.
AzaperoneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Azaperone.
AzelastineMethadyl Acetate may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
AzelastineThe risk or severity of adverse effects can be increased when Azelastine is combined with Methadyl Acetate.
AzosemideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Azosemide.
BaclofenThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Baclofen.
BarbitalThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Barbital.
BenactyzineThe risk or severity of adverse effects can be increased when Benactyzine is combined with Methadyl Acetate.
BendroflumethiazideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Bendroflumethiazide.
BenzatropineThe risk or severity of adverse effects can be increased when Benzatropine is combined with Methadyl Acetate.
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Methadyl Acetate.
BenzphetamineBenzphetamine may increase the analgesic activities of Methadyl Acetate.
Benzyl alcoholThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Benzyl alcohol.
BiperidenThe risk or severity of adverse effects can be increased when Biperiden is combined with Methadyl Acetate.
BrexpiprazoleThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Brexpiprazole.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Methadyl Acetate.
BrimonidineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Brimonidine.
BromazepamThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Bromazepam.
BrompheniramineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Brompheniramine.
BrotizolamThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Brotizolam.
BumetanideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Bumetanide.
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Methadyl Acetate.
BuprenorphineBuprenorphine may decrease the analgesic activities of Methadyl Acetate.
BuprenorphineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Buprenorphine.
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Methadyl Acetate.
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Methadyl Acetate.
ButacaineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Butacaine.
ButalbitalThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Butalbital.
ButambenThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Butamben.
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Methadyl Acetate.
ButorphanolButorphanol may decrease the analgesic activities of Methadyl Acetate.
ButorphanolThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Butorphanol.
Canrenoic acidThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Canrenoic acid.
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Methadyl Acetate.
CarbinoxamineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Carbinoxamine.
CarfentanilThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Carfentanil.
CarisoprodolThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Carisoprodol.
CetirizineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Cetirizine.
Chloral hydrateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Chloral hydrate.
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Methadyl Acetate.
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Methadyl Acetate.
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Methadyl Acetate.
ChlorothiazideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Chlorothiazide.
ChlorphenamineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Chlorphenamine.
ChlorphenoxamineThe risk or severity of adverse effects can be increased when Chlorphenoxamine is combined with Methadyl Acetate.
ChlorphentermineChlorphentermine may increase the analgesic activities of Methadyl Acetate.
ChlorpromazineChlorpromazine may increase the hypotensive activities of Methadyl Acetate.
ChlorpromazineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Chlorpromazine.
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Methadyl Acetate.
ChlorthalidoneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Chlorthalidone.
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Chlorzoxazone.
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Methadyl Acetate.
CitalopramMethadyl Acetate may increase the serotonergic activities of Citalopram.
ClemastineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Clemastine.
ClidiniumThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Clidinium.
ClobazamThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Clobazam.
clomethiazoleThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with clomethiazole.
ClomipramineMethadyl Acetate may increase the serotonergic activities of Clomipramine.
ClomipramineThe risk or severity of adverse effects can be increased when Clomipramine is combined with Methadyl Acetate.
ClonazepamThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Clonazepam.
ClonidineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Clonidine.
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Methadyl Acetate.
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Methadyl Acetate.
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Methadyl Acetate.
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Methadyl Acetate.
ConivaptanThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Conivaptan.
CyclizineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Cyclizine.
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Methadyl Acetate.
CyclopentolateThe risk or severity of adverse effects can be increased when Cyclopentolate is combined with Methadyl Acetate.
CyclothiazideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Cyclothiazide.
CyproheptadineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Cyproheptadine.
DantroleneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Dantrolene.
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Methadyl Acetate.
DapoxetineMethadyl Acetate may increase the serotonergic activities of Dapoxetine.
DarifenacinThe risk or severity of adverse effects can be increased when Darifenacin is combined with Methadyl Acetate.
deramciclaneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with deramciclane.
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Methadyl Acetate.
DesipramineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Desipramine.
DesloratadineThe risk or severity of adverse effects can be increased when Desloratadine is combined with Methadyl Acetate.
DesmopressinThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Desmopressin.
DetomidineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Detomidine.
DexbrompheniramineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Dexbrompheniramine.
DexetimideThe risk or severity of adverse effects can be increased when Dexetimide is combined with Methadyl Acetate.
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Methadyl Acetate.
DextroamphetamineDextroamphetamine may increase the analgesic activities of Methadyl Acetate.
DextromoramideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Dextromoramide.
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Methadyl Acetate.
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Methadyl Acetate.
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Methadyl Acetate.
DicyclomineThe risk or severity of adverse effects can be increased when Dicyclomine is combined with Methadyl Acetate.
DifenoxinThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Difenoxin.
DihydrocodeineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Dihydrocodeine.
DihydroetorphineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Dihydroetorphine.
DihydromorphineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Dihydromorphine.
DimenhydrinateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Dimenhydrinate.
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Methadyl Acetate.
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Methadyl Acetate.
DoramectinThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Doramectin.
DoxepinThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Doxepin.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Methadyl Acetate.
DoxylamineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Doxylamine.
DPDPEThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with DPDPE.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Methadyl Acetate.
DroperidolThe risk or severity of adverse effects can be increased when Droperidol is combined with Methadyl Acetate.
DrospirenoneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Drospirenone.
DrotebanolThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Drotebanol.
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Methadyl Acetate.
EcgonineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Ecgonine.
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with ECGONINE METHYL ESTER.
EfavirenzThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Efavirenz.
EfonidipineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Efonidipine.
EluxadolineMethadyl Acetate may increase the constipating activities of Eluxadoline.
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Methadyl Acetate.
EntacaponeThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Entacapone.
EplerenoneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Eplerenone.
EscitalopramMethadyl Acetate may increase the serotonergic activities of Escitalopram.
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Methadyl Acetate.
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Methadyl Acetate.
Etacrynic acidThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Etacrynic acid.
EthanolMethadyl Acetate may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
EthanolThe risk or severity of adverse effects can be increased when Ethanol is combined with Methadyl Acetate.
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Methadyl Acetate.
EthopropazineThe risk or severity of adverse effects can be increased when Ethopropazine is combined with Methadyl Acetate.
EthosuximideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Ethosuximide.
EthotoinThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Ethotoin.
EthoxzolamideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Ethoxzolamide.
Ethyl carbamateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Ethyl carbamate.
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Ethyl loflazepate.
EthylmorphineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Ethylmorphine.
EtidocaineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Etidocaine.
EtifoxineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Etifoxine.
EtizolamThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Etizolam.
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Methadyl Acetate.
EtoperidoneMethadyl Acetate may increase the serotonergic activities of Etoperidone.
EtorphineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Etorphine.
EzogabineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Ezogabine.
FelbamateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Felbamate.
FencamfamineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Fencamfamine.
FenfluramineMethadyl Acetate may increase the serotonergic activities of Fenfluramine.
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Methadyl Acetate.
FesoterodineThe risk or severity of adverse effects can be increased when Fesoterodine is combined with Methadyl Acetate.
FexofenadineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Fexofenadine.
FlibanserinThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Flibanserin.
FludiazepamThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Fludiazepam.
FlunarizineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Flunarizine.
FlunitrazepamThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Flunitrazepam.
FluoxetineMethadyl Acetate may increase the serotonergic activities of Fluoxetine.
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Methadyl Acetate.
FluphenazineFluphenazine may increase the hypotensive activities of Methadyl Acetate.
FluphenazineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Fluphenazine.
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Methadyl Acetate.
FluspirileneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Fluspirilene.
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Fluticasone Propionate.
FluvoxamineMethadyl Acetate may increase the serotonergic activities of Fluvoxamine.
FluvoxamineThe risk or severity of adverse effects can be increased when Fluvoxamine is combined with Methadyl Acetate.
FosphenytoinThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Fosphenytoin.
FospropofolThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Fospropofol.
FurosemideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Furosemide.
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Methadyl Acetate.
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with gabapentin enacarbil.
Gallamine TriethiodideThe risk or severity of adverse effects can be increased when Gallamine Triethiodide is combined with Methadyl Acetate.
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Gamma Hydroxybutyric Acid.
GlutethimideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Glutethimide.
GlycopyrroniumThe risk or severity of adverse effects can be increased when Glycopyrronium is combined with Methadyl Acetate.
GuanfacineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Guanfacine.
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Methadyl Acetate.
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Methadyl Acetate.
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Methadyl Acetate.
HeroinThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Heroin.
HexamethoniumThe risk or severity of adverse effects can be increased when Hexamethonium is combined with Methadyl Acetate.
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Methadyl Acetate.
HomatropineThe risk or severity of adverse effects can be increased when Homatropine is combined with Methadyl Acetate.
HydrochlorothiazideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Hydrochlorothiazide.
HydrocodoneThe risk or severity of adverse effects can be increased when Hydrocodone is combined with Methadyl Acetate.
HydroflumethiazideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Hydroflumethiazide.
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Methadyl Acetate.
Hydroxyamphetamine hydrobromideHydroxyamphetamine hydrobromide may increase the analgesic activities of Methadyl Acetate.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Methadyl Acetate.
HydroxyzineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Hydroxyzine.
HyoscyamineThe risk or severity of adverse effects can be increased when Hyoscyamine is combined with Methadyl Acetate.
IloperidoneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Iloperidone.
ImipramineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Imipramine.
IndalpineMethadyl Acetate may increase the serotonergic activities of Indalpine.
IndapamideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Indapamide.
Ipratropium bromideThe risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Methadyl Acetate.
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Methadyl Acetate.
IsosorbideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Isosorbide.
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Methadyl Acetate.
KetazolamThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Ketazolam.
KetobemidoneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Ketobemidone.
KW-3902The risk or severity of adverse effects can be increased when Methadyl Acetate is combined with KW-3902.
LamotrigineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Lamotrigine.
LevetiracetamThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Levetiracetam.
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Methadyl Acetate.
LevocabastineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Levocabastine.
LevocetirizineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Levocetirizine.
LevodopaThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Levodopa.
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Methadyl Acetate.
LevomilnacipranMethadyl Acetate may increase the serotonergic activities of Levomilnacipran.
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Methadyl Acetate.
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Methadyl Acetate.
LisdexamfetamineLisdexamfetamine may increase the analgesic activities of Methadyl Acetate.
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Methadyl Acetate.
LofentanilThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Lofentanil.
LoratadineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Loratadine.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Methadyl Acetate.
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Methadyl Acetate.
Lu AA21004Methadyl Acetate may increase the serotonergic activities of Lu AA21004.
Lu AA21004The risk or severity of adverse effects can be increased when Lu AA21004 is combined with Methadyl Acetate.
LurasidoneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Lurasidone.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Methadyl Acetate.
Magnesium SulfateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Magnesium Sulfate.
MannitolThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Mannitol.
MaprotilineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Maprotiline.
MecamylamineThe risk or severity of adverse effects can be increased when Mecamylamine is combined with Methadyl Acetate.
MeclizineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Meclizine.
MedetomidineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Medetomidine.
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Methadyl Acetate.
MelperoneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Melperone.
MephentermineMephentermine may increase the analgesic activities of Methadyl Acetate.
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Methadyl Acetate.
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Methadyl Acetate.
MersalylThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Mersalyl.
MesoridazineMesoridazine may increase the hypotensive activities of Methadyl Acetate.
MesoridazineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Mesoridazine.
MetaxaloneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Metaxalone.
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Methadyl Acetate.
MethamphetamineMethamphetamine may increase the analgesic activities of Methadyl Acetate.
MethanthelineThe risk or severity of adverse effects can be increased when Methantheline is combined with Methadyl Acetate.
MethapyrileneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Methapyrilene.
MethaqualoneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Methaqualone.
MethazolamideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Methazolamide.
MethocarbamolThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Methocarbamol.
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Methadyl Acetate.
MethotrimeprazineMethotrimeprazine may increase the hypotensive activities of Methadyl Acetate.
MethotrimeprazineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Methotrimeprazine.
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Methadyl Acetate.
MethsuximideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Methsuximide.
MethyclothiazideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Methyclothiazide.
Methylene blueMethylene blue may increase the hypotensive activities of Methadyl Acetate.
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Methadyl Acetate.
MetixeneThe risk or severity of adverse effects can be increased when Metixene is combined with Methadyl Acetate.
MetolazoneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Metolazone.
MetyrosineMethadyl Acetate may increase the sedative activities of Metyrosine.
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Methadyl Acetate.
MilnacipranMethadyl Acetate may increase the serotonergic activities of Milnacipran.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Methadyl Acetate.
MirtazapineMethadyl Acetate may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MirtazapineThe risk or severity of adverse effects can be increased when Mirtazapine is combined with Methadyl Acetate.
MolindoneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Molindone.
MoricizineMoricizine may increase the hypotensive activities of Methadyl Acetate.
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Methadyl Acetate.
N-butylscopolammonium bromideThe risk or severity of adverse effects can be increased when N-butylscopolammonium bromide is combined with Methadyl Acetate.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Methadyl Acetate.
NabiloneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Nabilone.
NalbuphineNalbuphine may decrease the analgesic activities of Methadyl Acetate.
NalbuphineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Nalbuphine.
NaltrexoneThe therapeutic efficacy of Methadyl Acetate can be decreased when used in combination with Naltrexone.
NitrazepamThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Nitrazepam.
Nitrous oxideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Nitrous oxide.
NormethadoneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Normethadone.
NortriptylineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Nortriptyline.
NVA237The risk or severity of adverse effects can be increased when NVA237 is combined with Methadyl Acetate.
OlanzapineMethadyl Acetate may increase the serotonergic activities of Olanzapine.
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Methadyl Acetate.
OlopatadineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Olopatadine.
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Methadyl Acetate.
OpiumThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Opium.
OrphenadrineMethadyl Acetate may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
OrphenadrineThe risk or severity of adverse effects can be increased when Orphenadrine is combined with Methadyl Acetate.
OsanetantThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Osanetant.
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Methadyl Acetate.
OxprenololThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Oxprenolol.
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Methadyl Acetate.
OxybutyninThe risk or severity of adverse effects can be increased when Oxybutynin is combined with Methadyl Acetate.
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Methadyl Acetate.
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Methadyl Acetate.
OxyphenoniumThe risk or severity of adverse effects can be increased when Oxyphenonium is combined with Methadyl Acetate.
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Methadyl Acetate.
PancuroniumThe risk or severity of adverse effects can be increased when Pancuronium is combined with Methadyl Acetate.
ParaldehydeMethadyl Acetate may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParaldehydeThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Methadyl Acetate.
ParoxetineMethadyl Acetate may increase the serotonergic activities of Paroxetine.
PegvisomantThe therapeutic efficacy of Pegvisomant can be decreased when used in combination with Methadyl Acetate.
PentazocinePentazocine may decrease the analgesic activities of Methadyl Acetate.
PentazocineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Pentazocine.
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Methadyl Acetate.
PentoliniumThe risk or severity of adverse effects can be increased when Pentolinium is combined with Methadyl Acetate.
PerampanelThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Perampanel.
PerospironeThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Perospirone.
PerphenazinePerphenazine may increase the hypotensive activities of Methadyl Acetate.
PerphenazineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Perphenazine.
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Methadyl Acetate.
PhenobarbitalThe risk or severity of adverse effects can be increased when Phenobarbital is combined with Methadyl Acetate.
PhenoxyethanolThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Phenoxyethanol.
PhenterminePhentermine may increase the analgesic activities of Methadyl Acetate.
PhenytoinThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Phenytoin.
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Methadyl Acetate.
PipamperoneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Pipamperone.
PipecuroniumThe risk or severity of adverse effects can be increased when Pipecuronium is combined with Methadyl Acetate.
PipotiazineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Pipotiazine.
PirenzepineThe risk or severity of adverse effects can be increased when Pirenzepine is combined with Methadyl Acetate.
PiretanideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Piretanide.
PizotifenThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Pizotifen.
PolythiazideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Polythiazide.
PomalidomideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Pomalidomide.
PotassiumThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Potassium.
Potassium CitrateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Potassium Citrate.
PramipexoleMethadyl Acetate may increase the sedative activities of Pramipexole.
PramocaineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Pramocaine.
PrazepamThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Prazepam.
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Methadyl Acetate.
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Methadyl Acetate.
PrimidoneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Primidone.
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Methadyl Acetate.
ProchlorperazineProchlorperazine may increase the hypotensive activities of Methadyl Acetate.
ProchlorperazineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Prochlorperazine.
ProcyclidineThe risk or severity of adverse effects can be increased when Procyclidine is combined with Methadyl Acetate.
PromazinePromazine may increase the hypotensive activities of Methadyl Acetate.
PromazineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Promazine.
PromethazinePromethazine may increase the hypotensive activities of Methadyl Acetate.
PromethazineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Promethazine.
PropanthelineThe risk or severity of adverse effects can be increased when Propantheline is combined with Methadyl Acetate.
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Methadyl Acetate.
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Methadyl Acetate.
PropoxycaineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Propoxycaine.
ProtriptylineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Protriptyline.
PSD502The risk or severity of adverse effects can be increased when Methadyl Acetate is combined with PSD502.
QuazepamThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Quazepam.
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Methadyl Acetate.
QuinethazoneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Quinethazone.
QuinidineThe risk or severity of adverse effects can be increased when Quinidine is combined with Methadyl Acetate.
RamelteonThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Ramelteon.
RamosetronMethadyl Acetate may increase the constipating activities of Ramosetron.
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Methadyl Acetate.
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Methadyl Acetate.
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Methadyl Acetate.
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Methadyl Acetate.
RomifidineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Romifidine.
RopiniroleMethadyl Acetate may increase the sedative activities of Ropinirole.
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Methadyl Acetate.
RotigotineMethadyl Acetate may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Methadyl Acetate.
S-EthylisothioureaThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with S-Ethylisothiourea.
ScopolamineThe risk or severity of adverse effects can be increased when Scopolamine is combined with Methadyl Acetate.
Scopolamine butylbromideThe risk or severity of adverse effects can be increased when Scopolamine butylbromide is combined with Methadyl Acetate.
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Methadyl Acetate.
SertindoleThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Sertindole.
SertralineMethadyl Acetate may increase the serotonergic activities of Sertraline.
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Methadyl Acetate.
Sodium oxybateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Sodium oxybate.
SolifenacinThe risk or severity of adverse effects can be increased when Solifenacin is combined with Methadyl Acetate.
SpironolactoneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Spironolactone.
StiripentolThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Stiripentol.
SuccinylcholineSuccinylcholine may increase the bradycardic activities of Methadyl Acetate.
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Methadyl Acetate.
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Methadyl Acetate.
SuvorexantThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Suvorexant.
TapentadolThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Tapentadol.
TasimelteonThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Tasimelteon.
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Methadyl Acetate.
TetrabenazineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Tetrabenazine.
TetracaineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Tetracaine.
TetrodotoxinThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Tetrodotoxin.
ThalidomideMethadyl Acetate may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
ThalidomideThe risk or severity of adverse effects can be increased when Thalidomide is combined with Methadyl Acetate.
TheobromineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Theobromine.
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Methadyl Acetate.
ThiethylperazineThiethylperazine may increase the hypotensive activities of Methadyl Acetate.
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Methadyl Acetate.
ThioridazineThioridazine may increase the hypotensive activities of Methadyl Acetate.
ThioridazineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Thioridazine.
ThiothixeneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Thiothixene.
TiagabineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Tiagabine.
TicrynafenThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Ticrynafen.
TiletamineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Tiletamine.
TiotropiumThe risk or severity of adverse effects can be increased when Tiotropium is combined with Methadyl Acetate.
TizanidineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Tizanidine.
TolcaponeThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Tolcapone.
TolterodineThe risk or severity of adverse effects can be increased when Tolterodine is combined with Methadyl Acetate.
TolvaptanThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Tolvaptan.
TopiramateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Topiramate.
TorasemideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Torasemide.
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Methadyl Acetate.
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Trans-2-Phenylcyclopropylamine.
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Methadyl Acetate.
TrazodoneMethadyl Acetate may increase the serotonergic activities of Trazodone.
TrazodoneThe risk or severity of adverse effects can be increased when Trazodone is combined with Methadyl Acetate.
TriamtereneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Triamterene.
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Methadyl Acetate.
TrichlormethiazideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Trichlormethiazide.
TrifluoperazineTrifluoperazine may increase the hypotensive activities of Methadyl Acetate.
TrifluoperazineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Trifluoperazine.
TriflupromazineTriflupromazine may increase the hypotensive activities of Methadyl Acetate.
TriflupromazineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Triflupromazine.
TrihexyphenidylThe risk or severity of adverse effects can be increased when Trihexyphenidyl is combined with Methadyl Acetate.
TrimethaphanThe risk or severity of adverse effects can be increased when Trimethaphan is combined with Methadyl Acetate.
TrimipramineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Trimipramine.
TriprolidineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Triprolidine.
TropicamideThe risk or severity of adverse effects can be increased when Tropicamide is combined with Methadyl Acetate.
TrospiumThe risk or severity of adverse effects can be increased when Trospium is combined with Methadyl Acetate.
TubocurarineThe risk or severity of adverse effects can be increased when Tubocurarine is combined with Methadyl Acetate.
UlaritideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Ularitide.
UmeclidiniumThe risk or severity of adverse effects can be increased when Umeclidinium is combined with Methadyl Acetate.
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Methadyl Acetate.
VecuroniumThe risk or severity of adverse effects can be increased when Vecuronium is combined with Methadyl Acetate.
VigabatrinThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Vigabatrin.
VilazodoneMethadyl Acetate may increase the serotonergic activities of Vilazodone.
VortioxetineMethadyl Acetate may increase the serotonergic activities of Vortioxetine.
VortioxetineThe risk or severity of adverse effects can be increased when Vortioxetine is combined with Methadyl Acetate.
XylazineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Xylazine.
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Methadyl Acetate.
ZiconotideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Ziconotide.
ZimelidineMethadyl Acetate may increase the serotonergic activities of Zimelidine.
ZiprasidoneThe risk or severity of adverse effects can be increased when Ziprasidone is combined with Methadyl Acetate.
ZolazepamThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Zolazepam.
ZolpidemThe risk or severity of adverse effects can be increased when Zolpidem is combined with Methadyl Acetate.
ZonisamideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Zonisamide.
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Methadyl Acetate.
ZotepineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Zotepine.
ZuclopenthixolThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Zuclopenthixol.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Voltage-gated calcium channel activity
Specific Function:
Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociati...
Gene Name:
OPRM1
Uniprot ID:
P35372
Molecular Weight:
44778.855 Da
References
  1. Mancino MJ, McGaugh J, Feldman Z, Poling J, Oliveto A: Effect of PTSD diagnosis and contingency management procedures on cocaine use in dually cocaine- and opioid-dependent individuals maintained on LAAM: a retrospective analysis. Am J Addict. 2010 Mar-Apr;19(2):169-77. doi: 10.1111/j.1521-0391.2009.00025.x. [PubMed:20163389 ]
  2. Walczak SA, Makman MH, Gardner EL: Acetylmethadol metabolites influence opiate receptors and adenylate cyclase in amygdala. Eur J Pharmacol. 1981 Jul 10;72(4):343-9. [PubMed:6268422 ]
  3. Wolstein J, Gastpar M, Finkbeiner T, Heinrich C, Heitkamp R, Poehlke T, Scherbaum N: A randomized, open-label trial comparing methadone and Levo-Alpha-Acetylmethadol (LAAM) in maintenance treatment of opioid addiction. Pharmacopsychiatry. 2009 Jan;42(1):1-8. doi: 10.1055/s-0028-1083818. Epub 2009 Jan 19. [PubMed:19153939 ]
  4. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
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Drug created on July 24, 2007 14:16 / Updated on August 17, 2016 12:23