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Identification
NameHeroin
Accession NumberDB01452
TypeSmall Molecule
GroupsApproved, Illicit
DescriptionA narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. Code of Federal Regulations, Title 21 Parts 329.1, 1308.11 (1987). Sale is forbidden in the United States by Federal statute. (Merck Index, 11th ed) Internationally, heroin is controlled under Schedules I and IV of the Single Convention on Narcotic Drugs. It is illegal to manufacture, possess, or sell heroin in the United States and the UK. However, under the name diamorphine, heroin is a legal prescription drug in the United Kingdom.
Structure
Thumb
Synonyms
(5alpha,6alpha)-7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol diacetate (ester)
3,6-Diacetylmorphine
7,8-Dihydro-4,5-alpha-epoxy-17-methylmorphinan-3,6-alpha-diol diacetate
diacetylmorphine
diamorphine
Heroin
morphine diacetate
O,O'-diacetylmorphine
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Heroin hydrochloride
Thumb
  • InChI Key: FZJYQGFGNHGSFX-PVQKIFDLSA-N
  • Monoisotopic Mass: 405.13430059
  • Average Mass: 405.872
DBSALT000095
Categories
UNII70D95007SX
CAS number561-27-3
WeightAverage: 369.411
Monoisotopic: 369.157622851
Chemical FormulaC21H23NO5
InChI KeyInChIKey=GVGLGOZIDCSQPN-PVHGPHFFSA-N
InChI
InChI=1S/C21H23NO5/c1-11(23)25-16-6-4-13-10-15-14-5-7-17(26-12(2)24)20-21(14,8-9-22(15)3)18(13)19(16)27-20/h4-7,14-15,17,20H,8-10H2,1-3H3/t14-,15+,17-,20-,21-/m0/s1
IUPAC Name
(1S,5R,13R,14S,17R)-14-(acetyloxy)-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0¹,¹³.0⁵,¹⁷.0⁷,¹⁸]octadeca-7(18),8,10,15-tetraen-10-yl acetate
SMILES
[H][C@@]12OC3=C(OC(C)=O)C=CC4=C3[C@@]11CCN(C)[C@]([H])(C4)[C@]1([H])C=C[C@@H]2OC(C)=O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as morphinans. These are polycyclic compounds with a four-ring skeleton with three condensed six-member rings forming a partially hydrogenated phenanthrene moiety, one of which is aromatic while the two others are alicyclic.
KingdomOrganic compounds
Super ClassAlkaloids and derivatives
ClassMorphinans
Sub ClassNot Available
Direct ParentMorphinans
Alternative Parents
Substituents
  • Morphinan
  • Benzylisoquinoline
  • Phenanthrene
  • Tetralin
  • Benzofuran
  • Aralkylamine
  • Alkyl aryl ether
  • Benzenoid
  • Piperidine
  • Acetate salt
  • Tertiary aliphatic amine
  • Tertiary amine
  • Carboxylic acid ester
  • Oxacycle
  • Azacycle
  • Organoheterocyclic compound
  • Ether
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationUsed in the treatment of acute pain, myocardial infarction, acute pulmonary oedema, and chronic pain.
PharmacodynamicsThe onset of heroin's effects is dependent on the method of administration. Taken orally, heroin is totally metabolized in vivo into morphine before crossing the blood-brain barrier; so the effects are the same as oral morphine. Take by injection, heroin crosses into the brain. Once in the brain, heroin is rapidly metabolized into morphine by removal of the acetyl groups, therefore, it is known as a prodrug. It is the morphine molecule that then binds with opioid receptors and produces the subjective effects of the heroin high.
Mechanism of actionHeroin is a mu-opioid agonist. It acts on endogenous mu-opioid receptors that are spread in discrete packets throughout the brain, spinal cord and gut in almost all mammals. Heroin, along with other opioids, are agonists to four endogenous neurotransmitters. They are beta-endorphin, dynorphin, leu-enkephalin, and met-enkephalin. The body responds to heroin in the brain by reducing (and sometimes stopping) production of the endogenous opioids when heroin is present. Endorphins are regularly released in the brain and nerves, attenuating pain. Their other functions are still obscure, but are probably related to the effects produced by heroin besides analgesia (antitussin, anti-diarrheal).
Related Articles
AbsorptionBioavailability is less than 35%.
Volume of distributionNot Available
Protein binding0% (morphine metabolite 35%)
Metabolism

Hepatic.

SubstrateEnzymesProduct
Heroin
6-MonoacetylmorphineDetails
6-Monoacetylmorphine
morphineDetails
Heroin
morphineDetails
Route of elimination90% renal as glucuronides, rest biliary
Half life<10 minutes
ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Heroin Action PathwayDrug actionSMP00407
Heroin Metabolism PathwayDrug metabolismSMP00623
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9932
Blood Brain Barrier+0.9892
Caco-2 permeable+0.7924
P-glycoprotein substrateSubstrate0.837
P-glycoprotein inhibitor IInhibitor0.8674
P-glycoprotein inhibitor IINon-inhibitor0.6816
Renal organic cation transporterNon-inhibitor0.5372
CYP450 2C9 substrateNon-substrate0.8192
CYP450 2D6 substrateSubstrate0.6599
CYP450 3A4 substrateSubstrate0.7803
CYP450 1A2 substrateNon-inhibitor0.7994
CYP450 2C9 inhibitorNon-inhibitor0.8162
CYP450 2D6 inhibitorNon-inhibitor0.6335
CYP450 2C19 inhibitorNon-inhibitor0.8059
CYP450 3A4 inhibitorNon-inhibitor0.8072
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8335
Ames testNon AMES toxic0.6935
CarcinogenicityNon-carcinogens0.9341
BiodegradationNot ready biodegradable0.9696
Rat acute toxicity2.8951 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9038
hERG inhibition (predictor II)Non-inhibitor0.9086
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point173 °CPhysProp
boiling point272-274 °C at 1.20E+01 mm HgPhysProp
water solubility600 mg/L (at 25 °C)SEIDELL,A (1941)
logP1.58AVDEEF,A ET AL. (1996)
pKa7.95 (at 25 °C)AVDEEF,A ET AL. (1996)
Predicted Properties
PropertyValueSource
Water Solubility0.266 mg/mLALOGPS
logP2.3ALOGPS
logP1.55ChemAxon
logS-3.1ALOGPS
pKa (Strongest Basic)9.1ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area65.07 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity98.43 m3·mol-1ChemAxon
Polarizability37.9 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
MSMass Spectrum (Electron Ionization)splash10-016u-5955000000-17dd3ef75849a9fb63c3View in MoNA
References
Synthesis ReferenceNot Available
General References
  1. Tschacher W, Haemmig R, Jacobshagen N: Time series modeling of heroin and morphine drug action. Psychopharmacology (Berl). 2003 Jan;165(2):188-93. Epub 2002 Oct 29. [PubMed:12404073 ]
External Links
ATC CodesN07BC06
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (18.8 KB)
Interactions
Drug Interactions
Drug
3,4-Methylenedioxyamphetamine3,4-Methylenedioxyamphetamine may increase the analgesic activities of Heroin.
3,4-Methylenedioxymethamphetamine3,4-Methylenedioxymethamphetamine may increase the analgesic activities of Heroin.
7-NitroindazoleThe risk or severity of adverse effects can be increased when Heroin is combined with 7-Nitroindazole.
AcepromazineAcepromazine may increase the hypotensive activities of Heroin.
AcepromazineThe risk or severity of adverse effects can be increased when Heroin is combined with Acepromazine.
AceprometazineThe risk or severity of adverse effects can be increased when Heroin is combined with Aceprometazine.
AcetazolamideThe risk or severity of adverse effects can be increased when Heroin is combined with Acetazolamide.
AclidiniumThe risk or severity of adverse effects can be increased when Aclidinium is combined with Heroin.
adipiplonThe risk or severity of adverse effects can be increased when Heroin is combined with adipiplon.
AgomelatineThe risk or severity of adverse effects can be increased when Heroin is combined with Agomelatine.
AlfaxaloneThe risk or severity of adverse effects can be increased when Heroin is combined with Alfaxalone.
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Heroin.
AlimemazineAlimemazine may increase the hypotensive activities of Heroin.
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Heroin is combined with Alphacetylmethadol.
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Heroin.
AlvimopanThe risk or severity of adverse effects can be increased when Heroin is combined with Alvimopan.
AmilorideThe risk or severity of adverse effects can be increased when Heroin is combined with Amiloride.
AmisulprideThe risk or severity of adverse effects can be increased when Heroin is combined with Amisulpride.
AmitriptylineThe risk or severity of adverse effects can be increased when Heroin is combined with Amitriptyline.
Ammonium chlorideAmmonium chloride may increase the excretion rate of Heroin which could result in a higher serum level.
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Heroin.
AmoxapineHeroin may increase the serotonergic activities of Amoxapine.
AmoxapineThe risk or severity of adverse effects can be increased when Amoxapine is combined with Heroin.
AmperozideThe risk or severity of adverse effects can be increased when Heroin is combined with Amperozide.
AmphetamineAmphetamine may increase the analgesic activities of Heroin.
Anisotropine MethylbromideThe risk or severity of adverse effects can be increased when Anisotropine Methylbromide is combined with Heroin.
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Heroin.
ArticaineThe risk or severity of adverse effects can be increased when Heroin is combined with Articaine.
AsenapineThe risk or severity of adverse effects can be increased when Heroin is combined with Asenapine.
Atracurium besylateThe risk or severity of adverse effects can be increased when Atracurium besylate is combined with Heroin.
AtropineThe risk or severity of adverse effects can be increased when Atropine is combined with Heroin.
AzaperoneThe risk or severity of adverse effects can be increased when Heroin is combined with Azaperone.
AzelastineHeroin may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
AzelastineThe risk or severity of adverse effects can be increased when Azelastine is combined with Heroin.
AzosemideThe risk or severity of adverse effects can be increased when Heroin is combined with Azosemide.
BaclofenThe risk or severity of adverse effects can be increased when Heroin is combined with Baclofen.
BarbitalThe risk or severity of adverse effects can be increased when Heroin is combined with Barbital.
BenactyzineThe risk or severity of adverse effects can be increased when Benactyzine is combined with Heroin.
BendroflumethiazideThe risk or severity of adverse effects can be increased when Heroin is combined with Bendroflumethiazide.
BenzatropineThe risk or severity of adverse effects can be increased when Benzatropine is combined with Heroin.
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Heroin.
BenzphetamineBenzphetamine may increase the analgesic activities of Heroin.
Benzyl alcoholThe risk or severity of adverse effects can be increased when Heroin is combined with Benzyl alcohol.
BiperidenThe risk or severity of adverse effects can be increased when Biperiden is combined with Heroin.
BrexpiprazoleThe risk or severity of adverse effects can be increased when Heroin is combined with Brexpiprazole.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Heroin.
BrimonidineThe risk or severity of adverse effects can be increased when Heroin is combined with Brimonidine.
BromazepamThe risk or severity of adverse effects can be increased when Heroin is combined with Bromazepam.
BrompheniramineThe risk or severity of adverse effects can be increased when Heroin is combined with Brompheniramine.
BrotizolamThe risk or severity of adverse effects can be increased when Heroin is combined with Brotizolam.
BumetanideThe risk or severity of adverse effects can be increased when Heroin is combined with Bumetanide.
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Heroin.
BuprenorphineBuprenorphine may decrease the analgesic activities of Heroin.
BuprenorphineThe risk or severity of adverse effects can be increased when Heroin is combined with Buprenorphine.
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Heroin.
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Heroin.
ButacaineThe risk or severity of adverse effects can be increased when Heroin is combined with Butacaine.
ButalbitalThe risk or severity of adverse effects can be increased when Heroin is combined with Butalbital.
ButambenThe risk or severity of adverse effects can be increased when Heroin is combined with Butamben.
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Heroin.
ButorphanolButorphanol may decrease the analgesic activities of Heroin.
ButorphanolThe risk or severity of adverse effects can be increased when Heroin is combined with Butorphanol.
Canrenoic acidThe risk or severity of adverse effects can be increased when Heroin is combined with Canrenoic acid.
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Heroin.
CarbinoxamineThe risk or severity of adverse effects can be increased when Heroin is combined with Carbinoxamine.
CarfentanilThe risk or severity of adverse effects can be increased when Heroin is combined with Carfentanil.
CarisoprodolThe risk or severity of adverse effects can be increased when Heroin is combined with Carisoprodol.
CetirizineThe risk or severity of adverse effects can be increased when Heroin is combined with Cetirizine.
Chloral hydrateThe risk or severity of adverse effects can be increased when Heroin is combined with Chloral hydrate.
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Heroin.
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Heroin.
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Heroin.
ChlorothiazideThe risk or severity of adverse effects can be increased when Heroin is combined with Chlorothiazide.
ChlorphenamineThe risk or severity of adverse effects can be increased when Heroin is combined with Chlorphenamine.
ChlorphenoxamineThe risk or severity of adverse effects can be increased when Chlorphenoxamine is combined with Heroin.
ChlorphentermineChlorphentermine may increase the analgesic activities of Heroin.
ChlorpromazineChlorpromazine may increase the hypotensive activities of Heroin.
ChlorpromazineThe risk or severity of adverse effects can be increased when Heroin is combined with Chlorpromazine.
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Heroin.
ChlorthalidoneThe risk or severity of adverse effects can be increased when Heroin is combined with Chlorthalidone.
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Heroin is combined with Chlorzoxazone.
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Heroin.
CitalopramHeroin may increase the serotonergic activities of Citalopram.
ClemastineThe risk or severity of adverse effects can be increased when Heroin is combined with Clemastine.
ClidiniumThe risk or severity of adverse effects can be increased when Heroin is combined with Clidinium.
ClobazamThe risk or severity of adverse effects can be increased when Heroin is combined with Clobazam.
clomethiazoleThe risk or severity of adverse effects can be increased when Heroin is combined with clomethiazole.
ClomipramineHeroin may increase the serotonergic activities of Clomipramine.
ClomipramineThe risk or severity of adverse effects can be increased when Clomipramine is combined with Heroin.
ClonazepamThe risk or severity of adverse effects can be increased when Heroin is combined with Clonazepam.
ClonidineThe risk or severity of adverse effects can be increased when Heroin is combined with Clonidine.
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Heroin.
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Heroin.
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Heroin.
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Heroin.
ConivaptanThe risk or severity of adverse effects can be increased when Heroin is combined with Conivaptan.
CyclizineThe risk or severity of adverse effects can be increased when Heroin is combined with Cyclizine.
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Heroin.
CyclopentolateThe risk or severity of adverse effects can be increased when Cyclopentolate is combined with Heroin.
CyclothiazideThe risk or severity of adverse effects can be increased when Heroin is combined with Cyclothiazide.
CyproheptadineThe risk or severity of adverse effects can be increased when Heroin is combined with Cyproheptadine.
DantroleneThe risk or severity of adverse effects can be increased when Heroin is combined with Dantrolene.
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Heroin.
DapoxetineHeroin may increase the serotonergic activities of Dapoxetine.
DarifenacinThe risk or severity of adverse effects can be increased when Darifenacin is combined with Heroin.
deramciclaneThe risk or severity of adverse effects can be increased when Heroin is combined with deramciclane.
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Heroin.
DesipramineThe risk or severity of adverse effects can be increased when Heroin is combined with Desipramine.
DesloratadineThe risk or severity of adverse effects can be increased when Desloratadine is combined with Heroin.
DesmopressinThe risk or severity of adverse effects can be increased when Heroin is combined with Desmopressin.
DetomidineThe risk or severity of adverse effects can be increased when Heroin is combined with Detomidine.
DexbrompheniramineThe risk or severity of adverse effects can be increased when Heroin is combined with Dexbrompheniramine.
DexetimideThe risk or severity of adverse effects can be increased when Dexetimide is combined with Heroin.
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Heroin.
DextroamphetamineDextroamphetamine may increase the analgesic activities of Heroin.
DextromoramideThe risk or severity of adverse effects can be increased when Heroin is combined with Dextromoramide.
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Heroin.
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Heroin.
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Heroin.
DicyclomineThe risk or severity of adverse effects can be increased when Dicyclomine is combined with Heroin.
DifenoxinThe risk or severity of adverse effects can be increased when Heroin is combined with Difenoxin.
DihydrocodeineThe risk or severity of adverse effects can be increased when Heroin is combined with Dihydrocodeine.
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Heroin.
DihydromorphineThe risk or severity of adverse effects can be increased when Heroin is combined with Dihydromorphine.
DimenhydrinateThe risk or severity of adverse effects can be increased when Heroin is combined with Dimenhydrinate.
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Heroin.
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Heroin.
DoramectinThe risk or severity of adverse effects can be increased when Heroin is combined with Doramectin.
DoxepinThe risk or severity of adverse effects can be increased when Heroin is combined with Doxepin.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Heroin.
DoxylamineThe risk or severity of adverse effects can be increased when Heroin is combined with Doxylamine.
DPDPEThe risk or severity of adverse effects can be increased when Heroin is combined with DPDPE.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Heroin.
DroperidolThe risk or severity of adverse effects can be increased when Droperidol is combined with Heroin.
DrospirenoneThe risk or severity of adverse effects can be increased when Heroin is combined with Drospirenone.
DrotebanolThe risk or severity of adverse effects can be increased when Heroin is combined with Drotebanol.
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Heroin.
EcgonineThe risk or severity of adverse effects can be increased when Heroin is combined with Ecgonine.
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when Heroin is combined with ECGONINE METHYL ESTER.
EfavirenzThe risk or severity of adverse effects can be increased when Heroin is combined with Efavirenz.
EfonidipineThe risk or severity of adverse effects can be increased when Heroin is combined with Efonidipine.
EluxadolineHeroin may increase the constipating activities of Eluxadoline.
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Heroin.
EntacaponeThe risk or severity of adverse effects can be increased when Heroin is combined with Entacapone.
EplerenoneThe risk or severity of adverse effects can be increased when Heroin is combined with Eplerenone.
EscitalopramHeroin may increase the serotonergic activities of Escitalopram.
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Heroin.
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Heroin.
Etacrynic acidThe risk or severity of adverse effects can be increased when Heroin is combined with Etacrynic acid.
EthanolHeroin may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
EthanolThe risk or severity of adverse effects can be increased when Ethanol is combined with Heroin.
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Heroin.
EthopropazineThe risk or severity of adverse effects can be increased when Ethopropazine is combined with Heroin.
EthosuximideThe risk or severity of adverse effects can be increased when Heroin is combined with Ethosuximide.
EthotoinThe risk or severity of adverse effects can be increased when Heroin is combined with Ethotoin.
EthoxzolamideThe risk or severity of adverse effects can be increased when Heroin is combined with Ethoxzolamide.
Ethyl carbamateThe risk or severity of adverse effects can be increased when Heroin is combined with Ethyl carbamate.
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Heroin is combined with Ethyl loflazepate.
EthylmorphineThe risk or severity of adverse effects can be increased when Heroin is combined with Ethylmorphine.
EtidocaineThe risk or severity of adverse effects can be increased when Heroin is combined with Etidocaine.
EtifoxineThe risk or severity of adverse effects can be increased when Heroin is combined with Etifoxine.
EtizolamThe risk or severity of adverse effects can be increased when Heroin is combined with Etizolam.
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Heroin.
EtoperidoneHeroin may increase the serotonergic activities of Etoperidone.
EtorphineThe risk or severity of adverse effects can be increased when Heroin is combined with Etorphine.
EzogabineThe risk or severity of adverse effects can be increased when Heroin is combined with Ezogabine.
FelbamateThe risk or severity of adverse effects can be increased when Heroin is combined with Felbamate.
FencamfamineThe risk or severity of adverse effects can be increased when Heroin is combined with Fencamfamine.
FenfluramineHeroin may increase the serotonergic activities of Fenfluramine.
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Heroin.
FesoterodineThe risk or severity of adverse effects can be increased when Fesoterodine is combined with Heroin.
FexofenadineThe risk or severity of adverse effects can be increased when Heroin is combined with Fexofenadine.
FlibanserinThe risk or severity of adverse effects can be increased when Heroin is combined with Flibanserin.
FludiazepamThe risk or severity of adverse effects can be increased when Heroin is combined with Fludiazepam.
FlunarizineThe risk or severity of adverse effects can be increased when Heroin is combined with Flunarizine.
FlunitrazepamThe risk or severity of adverse effects can be increased when Heroin is combined with Flunitrazepam.
FluoxetineHeroin may increase the serotonergic activities of Fluoxetine.
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Heroin.
FluphenazineFluphenazine may increase the hypotensive activities of Heroin.
FluphenazineThe risk or severity of adverse effects can be increased when Heroin is combined with Fluphenazine.
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Heroin.
FluspirileneThe risk or severity of adverse effects can be increased when Heroin is combined with Fluspirilene.
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Heroin is combined with Fluticasone Propionate.
FluvoxamineHeroin may increase the serotonergic activities of Fluvoxamine.
FluvoxamineThe risk or severity of adverse effects can be increased when Fluvoxamine is combined with Heroin.
FosphenytoinThe risk or severity of adverse effects can be increased when Heroin is combined with Fosphenytoin.
FospropofolThe risk or severity of adverse effects can be increased when Heroin is combined with Fospropofol.
FurosemideThe risk or severity of adverse effects can be increased when Heroin is combined with Furosemide.
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Heroin.
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Heroin is combined with gabapentin enacarbil.
Gallamine TriethiodideThe risk or severity of adverse effects can be increased when Gallamine Triethiodide is combined with Heroin.
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Heroin.
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Heroin.
GlycopyrroniumThe risk or severity of adverse effects can be increased when Glycopyrronium is combined with Heroin.
GuanfacineThe risk or severity of adverse effects can be increased when Heroin is combined with Guanfacine.
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Heroin.
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Heroin.
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Heroin.
HexamethoniumThe risk or severity of adverse effects can be increased when Hexamethonium is combined with Heroin.
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Heroin.
HomatropineThe risk or severity of adverse effects can be increased when Homatropine is combined with Heroin.
HydrochlorothiazideThe risk or severity of adverse effects can be increased when Heroin is combined with Hydrochlorothiazide.
HydrocodoneThe risk or severity of adverse effects can be increased when Hydrocodone is combined with Heroin.
HydroflumethiazideThe risk or severity of adverse effects can be increased when Heroin is combined with Hydroflumethiazide.
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Heroin.
Hydroxyamphetamine hydrobromideHydroxyamphetamine hydrobromide may increase the analgesic activities of Heroin.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Heroin.
HydroxyzineThe risk or severity of adverse effects can be increased when Heroin is combined with Hydroxyzine.
HyoscyamineThe risk or severity of adverse effects can be increased when Hyoscyamine is combined with Heroin.
IloperidoneThe risk or severity of adverse effects can be increased when Heroin is combined with Iloperidone.
ImipramineThe risk or severity of adverse effects can be increased when Heroin is combined with Imipramine.
IndalpineHeroin may increase the serotonergic activities of Indalpine.
IndapamideThe risk or severity of adverse effects can be increased when Heroin is combined with Indapamide.
Ipratropium bromideThe risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Heroin.
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Heroin.
IsosorbideThe risk or severity of adverse effects can be increased when Heroin is combined with Isosorbide.
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Heroin.
KetazolamThe risk or severity of adverse effects can be increased when Heroin is combined with Ketazolam.
KetobemidoneThe risk or severity of adverse effects can be increased when Heroin is combined with Ketobemidone.
KW-3902The risk or severity of adverse effects can be increased when Heroin is combined with KW-3902.
LamotrigineThe risk or severity of adverse effects can be increased when Heroin is combined with Lamotrigine.
LevetiracetamThe risk or severity of adverse effects can be increased when Heroin is combined with Levetiracetam.
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Heroin.
LevocabastineThe risk or severity of adverse effects can be increased when Heroin is combined with Levocabastine.
LevocetirizineThe risk or severity of adverse effects can be increased when Heroin is combined with Levocetirizine.
LevodopaThe risk or severity of adverse effects can be increased when Heroin is combined with Levodopa.
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Heroin.
LevomilnacipranHeroin may increase the serotonergic activities of Levomilnacipran.
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Heroin.
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Heroin.
LisdexamfetamineLisdexamfetamine may increase the analgesic activities of Heroin.
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Heroin.
LofentanilThe risk or severity of adverse effects can be increased when Heroin is combined with Lofentanil.
LoratadineThe risk or severity of adverse effects can be increased when Heroin is combined with Loratadine.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Heroin.
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Heroin.
Lu AA21004Heroin may increase the serotonergic activities of Lu AA21004.
Lu AA21004The risk or severity of adverse effects can be increased when Lu AA21004 is combined with Heroin.
LurasidoneThe risk or severity of adverse effects can be increased when Heroin is combined with Lurasidone.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Heroin.
Magnesium SulfateThe risk or severity of adverse effects can be increased when Heroin is combined with Magnesium Sulfate.
MannitolThe risk or severity of adverse effects can be increased when Heroin is combined with Mannitol.
MaprotilineThe risk or severity of adverse effects can be increased when Heroin is combined with Maprotiline.
MecamylamineThe risk or severity of adverse effects can be increased when Mecamylamine is combined with Heroin.
MeclizineThe risk or severity of adverse effects can be increased when Heroin is combined with Meclizine.
MedetomidineThe risk or severity of adverse effects can be increased when Heroin is combined with Medetomidine.
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Heroin.
MelperoneThe risk or severity of adverse effects can be increased when Heroin is combined with Melperone.
MephentermineMephentermine may increase the analgesic activities of Heroin.
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Heroin.
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Heroin.
MersalylThe risk or severity of adverse effects can be increased when Heroin is combined with Mersalyl.
MesoridazineMesoridazine may increase the hypotensive activities of Heroin.
MesoridazineThe risk or severity of adverse effects can be increased when Heroin is combined with Mesoridazine.
MetaxaloneThe risk or severity of adverse effects can be increased when Heroin is combined with Metaxalone.
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Heroin.
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Heroin.
MethamphetamineMethamphetamine may increase the analgesic activities of Heroin.
MethanthelineThe risk or severity of adverse effects can be increased when Methantheline is combined with Heroin.
MethapyrileneThe risk or severity of adverse effects can be increased when Heroin is combined with Methapyrilene.
MethaqualoneThe risk or severity of adverse effects can be increased when Heroin is combined with Methaqualone.
MethazolamideThe risk or severity of adverse effects can be increased when Heroin is combined with Methazolamide.
MethocarbamolThe risk or severity of adverse effects can be increased when Heroin is combined with Methocarbamol.
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Heroin.
MethotrimeprazineMethotrimeprazine may increase the hypotensive activities of Heroin.
MethotrimeprazineThe risk or severity of adverse effects can be increased when Heroin is combined with Methotrimeprazine.
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Heroin.
MethsuximideThe risk or severity of adverse effects can be increased when Heroin is combined with Methsuximide.
MethyclothiazideThe risk or severity of adverse effects can be increased when Heroin is combined with Methyclothiazide.
Methylene blueMethylene blue may increase the hypotensive activities of Heroin.
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Heroin.
MetixeneThe risk or severity of adverse effects can be increased when Metixene is combined with Heroin.
MetolazoneThe risk or severity of adverse effects can be increased when Heroin is combined with Metolazone.
MetyrosineHeroin may increase the sedative activities of Metyrosine.
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Heroin.
MilnacipranHeroin may increase the serotonergic activities of Milnacipran.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Heroin.
MirtazapineHeroin may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MirtazapineThe risk or severity of adverse effects can be increased when Mirtazapine is combined with Heroin.
MolindoneThe risk or severity of adverse effects can be increased when Heroin is combined with Molindone.
MoricizineMoricizine may increase the hypotensive activities of Heroin.
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Heroin.
N-butylscopolammonium bromideThe risk or severity of adverse effects can be increased when N-butylscopolammonium bromide is combined with Heroin.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Heroin.
NabiloneThe risk or severity of adverse effects can be increased when Heroin is combined with Nabilone.
NalbuphineNalbuphine may decrease the analgesic activities of Heroin.
NalbuphineThe risk or severity of adverse effects can be increased when Heroin is combined with Nalbuphine.
NaltrexoneThe therapeutic efficacy of Heroin can be decreased when used in combination with Naltrexone.
NitrazepamThe risk or severity of adverse effects can be increased when Heroin is combined with Nitrazepam.
Nitrous oxideThe risk or severity of adverse effects can be increased when Heroin is combined with Nitrous oxide.
NormethadoneThe risk or severity of adverse effects can be increased when Heroin is combined with Normethadone.
NortriptylineThe risk or severity of adverse effects can be increased when Heroin is combined with Nortriptyline.
NVA237The risk or severity of adverse effects can be increased when NVA237 is combined with Heroin.
OlanzapineHeroin may increase the serotonergic activities of Olanzapine.
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Heroin.
OlopatadineThe risk or severity of adverse effects can be increased when Heroin is combined with Olopatadine.
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Heroin.
OpiumThe risk or severity of adverse effects can be increased when Heroin is combined with Opium.
OrphenadrineHeroin may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
OrphenadrineThe risk or severity of adverse effects can be increased when Orphenadrine is combined with Heroin.
OsanetantThe risk or severity of adverse effects can be increased when Heroin is combined with Osanetant.
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Heroin.
OxprenololThe risk or severity of adverse effects can be increased when Heroin is combined with Oxprenolol.
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Heroin.
OxybutyninThe risk or severity of adverse effects can be increased when Oxybutynin is combined with Heroin.
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Heroin.
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Heroin.
OxyphenoniumThe risk or severity of adverse effects can be increased when Oxyphenonium is combined with Heroin.
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Heroin.
PancuroniumThe risk or severity of adverse effects can be increased when Pancuronium is combined with Heroin.
ParaldehydeHeroin may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParaldehydeThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Heroin.
ParoxetineHeroin may increase the serotonergic activities of Paroxetine.
PegvisomantThe therapeutic efficacy of Pegvisomant can be decreased when used in combination with Heroin.
PentazocinePentazocine may decrease the analgesic activities of Heroin.
PentazocineThe risk or severity of adverse effects can be increased when Heroin is combined with Pentazocine.
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Heroin.
PentoliniumThe risk or severity of adverse effects can be increased when Pentolinium is combined with Heroin.
PerampanelThe risk or severity of adverse effects can be increased when Heroin is combined with Perampanel.
PerospironeThe risk or severity of adverse effects can be increased when Heroin is combined with Perospirone.
PerphenazinePerphenazine may increase the hypotensive activities of Heroin.
PerphenazineThe risk or severity of adverse effects can be increased when Heroin is combined with Perphenazine.
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Heroin.
PhenobarbitalThe risk or severity of adverse effects can be increased when Phenobarbital is combined with Heroin.
PhenoxyethanolThe risk or severity of adverse effects can be increased when Heroin is combined with Phenoxyethanol.
PhenterminePhentermine may increase the analgesic activities of Heroin.
PhenytoinThe risk or severity of adverse effects can be increased when Heroin is combined with Phenytoin.
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Heroin.
PipamperoneThe risk or severity of adverse effects can be increased when Heroin is combined with Pipamperone.
PipecuroniumThe risk or severity of adverse effects can be increased when Pipecuronium is combined with Heroin.
PipotiazineThe risk or severity of adverse effects can be increased when Heroin is combined with Pipotiazine.
PirenzepineThe risk or severity of adverse effects can be increased when Pirenzepine is combined with Heroin.
PiretanideThe risk or severity of adverse effects can be increased when Heroin is combined with Piretanide.
PizotifenThe risk or severity of adverse effects can be increased when Heroin is combined with Pizotifen.
PolythiazideThe risk or severity of adverse effects can be increased when Heroin is combined with Polythiazide.
PomalidomideThe risk or severity of adverse effects can be increased when Heroin is combined with Pomalidomide.
PotassiumThe risk or severity of adverse effects can be increased when Heroin is combined with Potassium.
Potassium CitrateThe risk or severity of adverse effects can be increased when Heroin is combined with Potassium Citrate.
PramipexoleHeroin may increase the sedative activities of Pramipexole.
PramocaineThe risk or severity of adverse effects can be increased when Heroin is combined with Pramocaine.
PrazepamThe risk or severity of adverse effects can be increased when Heroin is combined with Prazepam.
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Heroin.
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Heroin.
PrimidoneThe risk or severity of adverse effects can be increased when Heroin is combined with Primidone.
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Heroin.
ProchlorperazineProchlorperazine may increase the hypotensive activities of Heroin.
ProchlorperazineThe risk or severity of adverse effects can be increased when Heroin is combined with Prochlorperazine.
ProcyclidineThe risk or severity of adverse effects can be increased when Procyclidine is combined with Heroin.
PromazinePromazine may increase the hypotensive activities of Heroin.
PromazineThe risk or severity of adverse effects can be increased when Heroin is combined with Promazine.
PromethazinePromethazine may increase the hypotensive activities of Heroin.
PromethazineThe risk or severity of adverse effects can be increased when Heroin is combined with Promethazine.
PropanthelineThe risk or severity of adverse effects can be increased when Propantheline is combined with Heroin.
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Heroin.
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Heroin.
PropoxycaineThe risk or severity of adverse effects can be increased when Heroin is combined with Propoxycaine.
ProtriptylineThe risk or severity of adverse effects can be increased when Heroin is combined with Protriptyline.
PSD502The risk or severity of adverse effects can be increased when Heroin is combined with PSD502.
QuazepamThe risk or severity of adverse effects can be increased when Heroin is combined with Quazepam.
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Heroin.
QuinethazoneThe risk or severity of adverse effects can be increased when Heroin is combined with Quinethazone.
QuinidineThe risk or severity of adverse effects can be increased when Quinidine is combined with Heroin.
RamelteonThe risk or severity of adverse effects can be increased when Heroin is combined with Ramelteon.
RamosetronHeroin may increase the constipating activities of Ramosetron.
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Heroin.
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Heroin.
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Heroin.
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Heroin.
RomifidineThe risk or severity of adverse effects can be increased when Heroin is combined with Romifidine.
RopiniroleHeroin may increase the sedative activities of Ropinirole.
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Heroin.
RotigotineHeroin may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Heroin.
S-EthylisothioureaThe risk or severity of adverse effects can be increased when Heroin is combined with S-Ethylisothiourea.
ScopolamineThe risk or severity of adverse effects can be increased when Scopolamine is combined with Heroin.
Scopolamine butylbromideThe risk or severity of adverse effects can be increased when Scopolamine butylbromide is combined with Heroin.
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Heroin.
SertindoleThe risk or severity of adverse effects can be increased when Heroin is combined with Sertindole.
SertralineHeroin may increase the serotonergic activities of Sertraline.
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Heroin.
Sodium oxybateThe risk or severity of adverse effects can be increased when Heroin is combined with Sodium oxybate.
SolifenacinThe risk or severity of adverse effects can be increased when Solifenacin is combined with Heroin.
SpironolactoneThe risk or severity of adverse effects can be increased when Heroin is combined with Spironolactone.
StiripentolThe risk or severity of adverse effects can be increased when Heroin is combined with Stiripentol.
SuccinylcholineSuccinylcholine may increase the bradycardic activities of Heroin.
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Heroin.
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Heroin.
SuvorexantThe risk or severity of adverse effects can be increased when Heroin is combined with Suvorexant.
TapentadolThe risk or severity of adverse effects can be increased when Heroin is combined with Tapentadol.
TasimelteonThe risk or severity of adverse effects can be increased when Heroin is combined with Tasimelteon.
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Heroin.
TetrabenazineThe risk or severity of adverse effects can be increased when Heroin is combined with Tetrabenazine.
TetracaineThe risk or severity of adverse effects can be increased when Heroin is combined with Tetracaine.
TetrodotoxinThe risk or severity of adverse effects can be increased when Heroin is combined with Tetrodotoxin.
ThalidomideHeroin may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
ThalidomideThe risk or severity of adverse effects can be increased when Thalidomide is combined with Heroin.
TheobromineThe risk or severity of adverse effects can be increased when Heroin is combined with Theobromine.
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Heroin.
ThiethylperazineThiethylperazine may increase the hypotensive activities of Heroin.
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Heroin.
ThioridazineThioridazine may increase the hypotensive activities of Heroin.
ThioridazineThe risk or severity of adverse effects can be increased when Heroin is combined with Thioridazine.
ThiothixeneThe risk or severity of adverse effects can be increased when Heroin is combined with Thiothixene.
TiagabineThe risk or severity of adverse effects can be increased when Heroin is combined with Tiagabine.
TicrynafenThe risk or severity of adverse effects can be increased when Heroin is combined with Ticrynafen.
TiletamineThe risk or severity of adverse effects can be increased when Heroin is combined with Tiletamine.
TiotropiumThe risk or severity of adverse effects can be increased when Tiotropium is combined with Heroin.
TizanidineThe risk or severity of adverse effects can be increased when Heroin is combined with Tizanidine.
TolcaponeThe risk or severity of adverse effects can be increased when Heroin is combined with Tolcapone.
TolterodineThe risk or severity of adverse effects can be increased when Tolterodine is combined with Heroin.
TolvaptanThe risk or severity of adverse effects can be increased when Heroin is combined with Tolvaptan.
TopiramateThe risk or severity of adverse effects can be increased when Heroin is combined with Topiramate.
TorasemideThe risk or severity of adverse effects can be increased when Heroin is combined with Torasemide.
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Heroin.
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Heroin is combined with Trans-2-Phenylcyclopropylamine.
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Heroin.
TrazodoneHeroin may increase the serotonergic activities of Trazodone.
TrazodoneThe risk or severity of adverse effects can be increased when Trazodone is combined with Heroin.
TriamtereneThe risk or severity of adverse effects can be increased when Heroin is combined with Triamterene.
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Heroin.
TrichlormethiazideThe risk or severity of adverse effects can be increased when Heroin is combined with Trichlormethiazide.
TrifluoperazineTrifluoperazine may increase the hypotensive activities of Heroin.
TrifluoperazineThe risk or severity of adverse effects can be increased when Heroin is combined with Trifluoperazine.
TriflupromazineTriflupromazine may increase the hypotensive activities of Heroin.
TriflupromazineThe risk or severity of adverse effects can be increased when Heroin is combined with Triflupromazine.
TrihexyphenidylThe risk or severity of adverse effects can be increased when Trihexyphenidyl is combined with Heroin.
TrimethaphanThe risk or severity of adverse effects can be increased when Trimethaphan is combined with Heroin.
TrimipramineThe risk or severity of adverse effects can be increased when Heroin is combined with Trimipramine.
TriprolidineThe risk or severity of adverse effects can be increased when Heroin is combined with Triprolidine.
TropicamideThe risk or severity of adverse effects can be increased when Tropicamide is combined with Heroin.
TrospiumThe risk or severity of adverse effects can be increased when Trospium is combined with Heroin.
TubocurarineThe risk or severity of adverse effects can be increased when Tubocurarine is combined with Heroin.
UlaritideThe risk or severity of adverse effects can be increased when Heroin is combined with Ularitide.
UmeclidiniumThe risk or severity of adverse effects can be increased when Umeclidinium is combined with Heroin.
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Heroin.
VecuroniumThe risk or severity of adverse effects can be increased when Vecuronium is combined with Heroin.
VigabatrinThe risk or severity of adverse effects can be increased when Heroin is combined with Vigabatrin.
VilazodoneHeroin may increase the serotonergic activities of Vilazodone.
VortioxetineHeroin may increase the serotonergic activities of Vortioxetine.
VortioxetineThe risk or severity of adverse effects can be increased when Vortioxetine is combined with Heroin.
XylazineThe risk or severity of adverse effects can be increased when Heroin is combined with Xylazine.
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Heroin.
ZiconotideThe risk or severity of adverse effects can be increased when Heroin is combined with Ziconotide.
ZimelidineHeroin may increase the serotonergic activities of Zimelidine.
ZiprasidoneThe risk or severity of adverse effects can be increased when Ziprasidone is combined with Heroin.
ZolazepamThe risk or severity of adverse effects can be increased when Heroin is combined with Zolazepam.
ZolpidemThe risk or severity of adverse effects can be increased when Zolpidem is combined with Heroin.
ZonisamideThe risk or severity of adverse effects can be increased when Heroin is combined with Zonisamide.
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Heroin.
ZotepineThe risk or severity of adverse effects can be increased when Heroin is combined with Zotepine.
ZuclopenthixolThe risk or severity of adverse effects can be increased when Heroin is combined with Zuclopenthixol.
Food Interactions
  • Avoid alcohol
  • To avoid constipation: increase your daily intake of fiber (beans, whole grains, vegetables).

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Voltage-gated calcium channel activity
Specific Function:
Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociati...
Gene Name:
OPRM1
Uniprot ID:
P35372
Molecular Weight:
44778.855 Da
References
  1. Greenwald MK, Johanson CE, Moody DE, Woods JH, Kilbourn MR, Koeppe RA, Schuster CR, Zubieta JK: Effects of buprenorphine maintenance dose on mu-opioid receptor availability, plasma concentrations, and antagonist blockade in heroin-dependent volunteers. Neuropsychopharmacology. 2003 Nov;28(11):2000-9. [PubMed:12902992 ]
  2. Becker J, Schmidt P, Musshoff F, Fitzenreiter M, Madea B: MOR1 receptor mRNA expression in human brains of drug-related fatalities-a real-time PCR quantification. Forensic Sci Int. 2004 Feb 10;140(1):13-20. [PubMed:15013161 ]
  3. Yao L, McFarland K, Fan P, Jiang Z, Inoue Y, Diamond I: Activator of G protein signaling 3 regulates opiate activation of protein kinase A signaling and relapse of heroin-seeking behavior. Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8746-51. Epub 2005 Jun 3. [PubMed:15937104 ]
  4. Antonilli L, Petecchia E, Caprioli D, Badiani A, Nencini P: Effect of repeated administrations of heroin, naltrexone, methadone, and alcohol on morphine glucuronidation in the rat. Psychopharmacology (Berl). 2005 Oct;182(1):58-64. Epub 2005 Sep 29. [PubMed:15986196 ]
  5. Choi HS, Kim CS, Hwang CK, Song KY, Wang W, Qiu Y, Law PY, Wei LN, Loh HH: The opioid ligand binding of human mu-opioid receptor is modulated by novel splice variants of the receptor. Biochem Biophys Res Commun. 2006 May 19;343(4):1132-40. Epub 2006 Mar 23. [PubMed:16580639 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Opioid receptor activity
Specific Function:
G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates th...
Gene Name:
OPRK1
Uniprot ID:
P41145
Molecular Weight:
42644.665 Da
References
  1. Wee S, Koob GF: The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse. Psychopharmacology (Berl). 2010 Jun;210(2):121-35. doi: 10.1007/s00213-010-1825-8. Epub 2010 Mar 30. [PubMed:20352414 ]
  2. Klein G, Juni A, Arout CA, Waxman AR, Inturrisi CE, Kest B: Acute and chronic heroin dependence in mice: contribution of opioid and excitatory amino acid receptors. Eur J Pharmacol. 2008 May 31;586(1-3):179-88. doi: 10.1016/j.ejphar.2008.02.035. Epub 2008 Feb 19. [PubMed:18343363 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Opioid receptor activity
Specific Function:
G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurot...
Gene Name:
OPRD1
Uniprot ID:
P41143
Molecular Weight:
40368.235 Da
References
  1. Klein G, Juni A, Arout CA, Waxman AR, Inturrisi CE, Kest B: Acute and chronic heroin dependence in mice: contribution of opioid and excitatory amino acid receptors. Eur J Pharmacol. 2008 May 31;586(1-3):179-88. doi: 10.1016/j.ejphar.2008.02.035. Epub 2008 Feb 19. [PubMed:18343363 ]
  2. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  3. Kieffer BL, Gaveriaux-Ruff C: Exploring the opioid system by gene knockout. Prog Neurobiol. 2002 Apr;66(5):285-306. [PubMed:12015197 ]
Comments
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Drug created on July 31, 2007 07:09 / Updated on August 17, 2016 12:23