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Identification
NameAcepromazine
Accession NumberDB01614
TypeSmall Molecule
GroupsApproved, Vet Approved
DescriptionAcepromazine is one of the phenothiazine derivative psychotropic drugs, used little in humans, however frequently in animals as a sedative and antiemetic.
Structure
Thumb
Synonyms
1-[10-(3-DIMETHYLAMINO-propyl)-10H-phenothiazin-2-yl]-ethanone
10-(3-dimethylaminopropyl)phenothiazin-3-yl methyl ketone
10-(3-dimethylaminopropyl)phenothiazine-3-ethylone
Acetazine
Acetopromazine
Acetylpromazine
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
Acezine 2Not Available
AtravetNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Acepromazine maleate
ThumbNot applicableDBSALT001612
Categories
UNII54EJ303F0R
CAS number61-00-7
WeightAverage: 326.456
Monoisotopic: 326.145284026
Chemical FormulaC19H22N2OS
InChI KeyInChIKey=NOSIYYJFMPDDSA-UHFFFAOYSA-N
InChI
InChI=1S/C19H22N2OS/c1-14(22)15-9-10-19-17(13-15)21(12-6-11-20(2)3)16-7-4-5-8-18(16)23-19/h4-5,7-10,13H,6,11-12H2,1-3H3
IUPAC Name
1-{10-[3-(dimethylamino)propyl]-10H-phenothiazin-2-yl}ethan-1-one
SMILES
CN(C)CCCN1C2=CC=CC=C2SC2=C1C=C(C=C2)C(C)=O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as phenothiazines. These are polycyclic aromatic compounds containing a phenothiazine moiety, which is a linear tricyclic system that consists of a two benzene rings joined by a para-thiazine ring.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassBenzothiazines
Sub ClassPhenothiazines
Direct ParentPhenothiazines
Alternative Parents
Substituents
  • Phenothiazine
  • Alkyldiarylamine
  • Diarylthioether
  • Acetophenone
  • Aryl alkyl ketone
  • Aryl ketone
  • Benzoyl
  • Benzenoid
  • Para-thiazine
  • Tertiary aliphatic amine
  • Tertiary amine
  • Ketone
  • Azacycle
  • Thioether
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationAcepromazine was first used in humans in the 1950s as an antipsychotic agent. It is now rarely used in humans. Acepromazine is frequently used in animals as a sedative and antiemetic. Its principal value is in quietening and calming anxious animals.
PharmacodynamicsAcepromazine is one of the phenothiazine derivative psychotropic drugs. Acepromazine has actions at all levels of the central nervous system-primarily at subcortical levels-as well as on multiple organ systems. Acepromazine has strong antiadrenergic and weaker peripheral anticholinergic activity; ganglionic blocking action is relatively slight. It also possesses slight antihistaminic and antiserotonin activity.
Mechanism of actionAcepromazine acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side-effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism - controversial) and finally on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side-effects).
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half life3 hours in horses.
ClearanceNot Available
ToxicityAgitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, restlessness
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9852
Blood Brain Barrier+0.9844
Caco-2 permeable+0.8203
P-glycoprotein substrateSubstrate0.8092
P-glycoprotein inhibitor IInhibitor0.8563
P-glycoprotein inhibitor IIInhibitor0.857
Renal organic cation transporterInhibitor0.7087
CYP450 2C9 substrateNon-substrate0.7438
CYP450 2D6 substrateSubstrate0.8618
CYP450 3A4 substrateSubstrate0.6468
CYP450 1A2 substrateInhibitor0.9106
CYP450 2C9 inhibitorNon-inhibitor0.9319
CYP450 2D6 inhibitorInhibitor0.9115
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.9105
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7333
Ames testNon AMES toxic0.849
CarcinogenicityNon-carcinogens0.9292
BiodegradationNot ready biodegradable0.9829
Rat acute toxicity2.7963 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9537
hERG inhibition (predictor II)Inhibitor0.7813
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
StateLiquid
Experimental Properties
PropertyValueSource
melting point< 25 °CPhysProp
boiling point230 °C at 5.00E-01 mm HgPhysProp
Predicted Properties
PropertyValueSource
Water Solubility0.0098 mg/mLALOGPS
logP4.32ALOGPS
logP3.49ChemAxon
logS-4.5ALOGPS
pKa (Strongest Acidic)16.06ChemAxon
pKa (Strongest Basic)8.5ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area23.55 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity99.35 m3·mol-1ChemAxon
Polarizability37.17 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (7.84 KB)
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesN05AA04
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
Interactions
Drug Interactions
Drug
3,4-MethylenedioxyamphetamineAcepromazine may decrease the stimulatory activities of 3,4-Methylenedioxyamphetamine.
3,4-MethylenedioxymethamphetamineAcepromazine may decrease the stimulatory activities of 3,4-Methylenedioxymethamphetamine.
5'-Deoxy-5'-MethylthioadenosineThe serum concentration of Acepromazine can be increased when it is combined with 5&#39;-Deoxy-5&#39;-Methylthioadenosine.
7-NitroindazoleThe risk or severity of adverse effects can be increased when Acepromazine is combined with 7-Nitroindazole.
AcebutololAcepromazine may increase the hypotensive activities of Acebutolol.
AceprometazineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Aceprometazine.
adipiplonThe risk or severity of adverse effects can be increased when Acepromazine is combined with adipiplon.
AgomelatineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Agomelatine.
AlfaxaloneThe risk or severity of adverse effects can be increased when Acepromazine is combined with Alfaxalone.
AlfentanilAcepromazine may increase the hypotensive activities of Alfentanil.
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Acepromazine.
AlmotriptanThe risk or severity of adverse effects can be increased when Almotriptan is combined with Acepromazine.
AlphacetylmethadolAcepromazine may increase the hypotensive activities of Alphacetylmethadol.
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Acepromazine.
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Acepromazine.
AlprenololAcepromazine may increase the hypotensive activities of Alprenolol.
Aluminum hydroxideAluminum hydroxide can cause a decrease in the absorption of Acepromazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aluminum phosphateAluminum phosphate can cause a decrease in the absorption of Acepromazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
AmisulprideThe risk or severity of adverse effects can be increased when Acepromazine is combined with Amisulpride.
AmitriptylineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Acepromazine.
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Acepromazine.
AmodiaquineThe serum concentration of Acepromazine can be increased when it is combined with Amodiaquine.
AmoxapineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Amoxapine.
AmperozideThe risk or severity of adverse effects can be increased when Acepromazine is combined with Amperozide.
AmphetamineAcepromazine may decrease the stimulatory activities of Amphetamine.
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Acepromazine.
ArotinololAcepromazine may increase the hypotensive activities of Arotinolol.
ArtemetherThe serum concentration of Acepromazine can be increased when it is combined with Artemether.
ArtesunateThe serum concentration of Acepromazine can be increased when it is combined with Artesunate.
ArticaineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Articaine.
AsenapineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Asenapine.
AtenololAcepromazine may increase the hypotensive activities of Atenolol.
AtovaquoneThe serum concentration of Acepromazine can be increased when it is combined with Atovaquone.
AzaperoneThe risk or severity of adverse effects can be increased when Acepromazine is combined with Azaperone.
AzelastineAcepromazine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
AzelastineThe risk or severity of adverse effects can be increased when Azelastine is combined with Acepromazine.
BaclofenThe risk or severity of adverse effects can be increased when Acepromazine is combined with Baclofen.
BarbitalThe risk or severity of adverse effects can be increased when Barbital is combined with Acepromazine.
BefunololAcepromazine may increase the hypotensive activities of Befunolol.
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Acepromazine.
BenzphetamineAcepromazine may decrease the stimulatory activities of Benzphetamine.
Benzyl alcoholThe risk or severity of adverse effects can be increased when Acepromazine is combined with Benzyl alcohol.
BetaxololAcepromazine may increase the hypotensive activities of Betaxolol.
BevantololAcepromazine may increase the hypotensive activities of Bevantolol.
BezitramideAcepromazine may increase the hypotensive activities of Bezitramide.
Bismuth SubcitrateBismuth Subcitrate can cause a decrease in the absorption of Acepromazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
BisoprololAcepromazine may increase the hypotensive activities of Bisoprolol.
BopindololAcepromazine may increase the hypotensive activities of Bopindolol.
BrexpiprazoleThe risk or severity of adverse effects can be increased when Acepromazine is combined with Brexpiprazole.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Acepromazine.
BrimonidineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Brimonidine.
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Acepromazine.
BromocriptineThe risk or severity of adverse effects can be increased when Bromocriptine is combined with Acepromazine.
BrompheniramineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Brompheniramine.
BrotizolamThe risk or severity of adverse effects can be increased when Acepromazine is combined with Brotizolam.
BufuralolAcepromazine may increase the hypotensive activities of Bufuralol.
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Acepromazine.
BupranololAcepromazine may increase the hypotensive activities of Bupranolol.
BuprenorphineAcepromazine may increase the hypotensive activities of Buprenorphine.
BuprenorphineThe risk or severity of adverse effects can be increased when Buprenorphine is combined with Acepromazine.
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Acepromazine.
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Acepromazine.
ButacaineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Butacaine.
ButalbitalThe risk or severity of adverse effects can be increased when Acepromazine is combined with Butalbital.
ButambenThe risk or severity of adverse effects can be increased when Acepromazine is combined with Butamben.
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Acepromazine.
ButorphanolAcepromazine may increase the hypotensive activities of Butorphanol.
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Acepromazine.
CabergolineThe risk or severity of adverse effects can be increased when Cabergoline is combined with Acepromazine.
Calcium carbonateCalcium carbonate can cause a decrease in the absorption of Acepromazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Acepromazine.
CarbinoxamineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Carbinoxamine.
CarfentanilAcepromazine may increase the hypotensive activities of Carfentanil.
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Acepromazine.
CarisoprodolThe risk or severity of adverse effects can be increased when Acepromazine is combined with Carisoprodol.
CarteololAcepromazine may increase the hypotensive activities of Carteolol.
CarvedilolAcepromazine may increase the hypotensive activities of Carvedilol.
CeliprololAcepromazine may increase the hypotensive activities of Celiprolol.
CetirizineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Cetirizine.
Chloral hydrateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Acepromazine.
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Acepromazine.
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Acepromazine.
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Acepromazine.
ChloroquineThe serum concentration of Acepromazine can be increased when it is combined with Chloroquine.
ChlorphenamineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Chlorphenamine.
ChlorphentermineAcepromazine may decrease the stimulatory activities of Chlorphentermine.
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with Acepromazine.
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Acepromazine.
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Acepromazine is combined with Chlorzoxazone.
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Acepromazine.
CitalopramThe risk or severity of adverse effects can be increased when Acepromazine is combined with Citalopram.
ClemastineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Clemastine.
ClidiniumThe risk or severity of adverse effects can be increased when Acepromazine is combined with Clidinium.
ClobazamThe risk or severity of adverse effects can be increased when Acepromazine is combined with Clobazam.
clomethiazoleThe risk or severity of adverse effects can be increased when Acepromazine is combined with clomethiazole.
ClomipramineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Clomipramine.
ClonazepamThe risk or severity of adverse effects can be increased when Acepromazine is combined with Clonazepam.
ClonidineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Clonidine.
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Acepromazine.
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Acepromazine.
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Acepromazine.
CodeineAcepromazine may increase the hypotensive activities of Codeine.
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Acepromazine.
CyclizineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Cyclizine.
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Acepromazine.
CyproheptadineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Cyproheptadine.
DantroleneThe risk or severity of adverse effects can be increased when Acepromazine is combined with Dantrolene.
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Acepromazine.
DapoxetineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Dapoxetine.
DapsoneThe serum concentration of Acepromazine can be increased when it is combined with Dapsone.
deramciclaneThe risk or severity of adverse effects can be increased when Acepromazine is combined with deramciclane.
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Acepromazine.
DesipramineThe risk or severity of adverse effects can be increased when Desipramine is combined with Acepromazine.
DesloratadineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Desloratadine.
DesvenlafaxineThe risk or severity of adverse effects can be increased when Desvenlafaxine is combined with Acepromazine.
DetomidineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Detomidine.
DexbrompheniramineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Dexbrompheniramine.
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Acepromazine.
DextroamphetamineAcepromazine may decrease the stimulatory activities of Dextroamphetamine.
DextromethorphanThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Acepromazine.
DextromoramideAcepromazine may increase the hypotensive activities of Dextromoramide.
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Acepromazine.
DextropropoxypheneAcepromazine may increase the hypotensive activities of Dextropropoxyphene.
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Acepromazine.
DezocineAcepromazine may increase the hypotensive activities of Dezocine.
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Acepromazine.
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Acepromazine.
DifenoxinThe risk or severity of adverse effects can be increased when Acepromazine is combined with Difenoxin.
DihydrocodeineAcepromazine may increase the hypotensive activities of Dihydrocodeine.
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Acepromazine.
DihydroergotamineThe risk or severity of adverse effects can be increased when Dihydroergotamine is combined with Acepromazine.
DihydroetorphineAcepromazine may increase the hypotensive activities of Dihydroetorphine.
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Acepromazine.
DihydromorphineAcepromazine may increase the hypotensive activities of Dihydromorphine.
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with Acepromazine.
DimenhydrinateThe risk or severity of adverse effects can be increased when Acepromazine is combined with Dimenhydrinate.
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Acepromazine.
DiphenoxylateAcepromazine may increase the hypotensive activities of Diphenoxylate.
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Acepromazine.
DoramectinThe risk or severity of adverse effects can be increased when Acepromazine is combined with Doramectin.
DoxepinThe risk or severity of adverse effects can be increased when Doxepin is combined with Acepromazine.
DoxycyclineThe serum concentration of Acepromazine can be increased when it is combined with Doxycycline.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Acepromazine.
DoxylamineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Doxylamine.
DPDPEAcepromazine may increase the hypotensive activities of DPDPE.
DPDPEThe risk or severity of adverse effects can be increased when DPDPE is combined with Acepromazine.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Acepromazine.
DroperidolThe risk or severity of adverse effects can be increased when Droperidol is combined with Acepromazine.
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Acepromazine.
DuloxetineThe risk or severity of adverse effects can be increased when Duloxetine is combined with Acepromazine.
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Acepromazine.
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Acepromazine.
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when Acepromazine is combined with ECGONINE METHYL ESTER.
EfavirenzThe risk or severity of adverse effects can be increased when Acepromazine is combined with Efavirenz.
EletriptanThe risk or severity of adverse effects can be increased when Eletriptan is combined with Acepromazine.
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Acepromazine.
EntacaponeThe risk or severity of adverse effects can be increased when Acepromazine is combined with Entacapone.
Ergoloid mesylateThe risk or severity of adverse effects can be increased when Ergoloid mesylate is combined with Acepromazine.
ErgonovineThe risk or severity of adverse effects can be increased when Ergonovine is combined with Acepromazine.
ErgotamineThe risk or severity of adverse effects can be increased when Ergotamine is combined with Acepromazine.
EscitalopramThe risk or severity of adverse effects can be increased when Acepromazine is combined with Escitalopram.
EsmololAcepromazine may increase the hypotensive activities of Esmolol.
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Acepromazine.
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Acepromazine.
EthanolAcepromazine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
EthanolThe risk or severity of adverse effects can be increased when Ethanol is combined with Acepromazine.
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Acepromazine.
EthosuximideThe risk or severity of adverse effects can be increased when Acepromazine is combined with Ethosuximide.
EthotoinThe risk or severity of adverse effects can be increased when Acepromazine is combined with Ethotoin.
Ethyl carbamateThe risk or severity of adverse effects can be increased when Acepromazine is combined with Ethyl carbamate.
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Acepromazine.
EthylmorphineAcepromazine may increase the hypotensive activities of Ethylmorphine.
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Acepromazine.
EtidocaineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Etidocaine.
EtifoxineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Etifoxine.
EtizolamThe risk or severity of adverse effects can be increased when Acepromazine is combined with Etizolam.
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Acepromazine.
EtoperidoneThe risk or severity of adverse effects can be increased when Acepromazine is combined with Etoperidone.
EtorphineAcepromazine may increase the hypotensive activities of Etorphine.
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Acepromazine.
EzogabineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Ezogabine.
FelbamateThe risk or severity of adverse effects can be increased when Acepromazine is combined with Felbamate.
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Acepromazine.
FenfluramineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Fenfluramine.
FentanylAcepromazine may increase the hypotensive activities of Fentanyl.
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Acepromazine.
FexofenadineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Fexofenadine.
FlibanserinThe risk or severity of adverse effects can be increased when Acepromazine is combined with Flibanserin.
FludiazepamThe risk or severity of adverse effects can be increased when Fludiazepam is combined with Acepromazine.
FlunarizineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Flunarizine.
FlunitrazepamThe risk or severity of adverse effects can be increased when Flunitrazepam is combined with Acepromazine.
FluoxetineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Fluoxetine.
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Acepromazine.
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Acepromazine.
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Acepromazine.
FluspirileneThe risk or severity of adverse effects can be increased when Acepromazine is combined with Fluspirilene.
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Acepromazine is combined with Fluticasone Propionate.
FluvoxamineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Fluvoxamine.
FosphenytoinThe risk or severity of adverse effects can be increased when Acepromazine is combined with Fosphenytoin.
FospropofolThe risk or severity of adverse effects can be increased when Acepromazine is combined with Fospropofol.
FrovatriptanThe risk or severity of adverse effects can be increased when Frovatriptan is combined with Acepromazine.
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Acepromazine.
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Acepromazine is combined with gabapentin enacarbil.
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Acepromazine.
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Acepromazine.
GuanfacineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Guanfacine.
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Acepromazine.
HalofantrineThe serum concentration of Acepromazine can be increased when it is combined with Halofantrine.
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Acepromazine.
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Acepromazine.
HeroinAcepromazine may increase the hypotensive activities of Heroin.
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Acepromazine.
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Acepromazine.
HydrocodoneAcepromazine may increase the hypotensive activities of Hydrocodone.
HydrocodoneThe risk or severity of adverse effects can be increased when Hydrocodone is combined with Acepromazine.
HydromorphoneAcepromazine may increase the hypotensive activities of Hydromorphone.
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Acepromazine.
Hydroxyamphetamine hydrobromideAcepromazine may decrease the stimulatory activities of Hydroxyamphetamine hydrobromide.
HydroxychloroquineThe serum concentration of Acepromazine can be increased when it is combined with Hydroxychloroquine.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Acepromazine.
HydroxyzineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Hydroxyzine.
IloperidoneThe risk or severity of adverse effects can be increased when Acepromazine is combined with Iloperidone.
ImipramineThe risk or severity of adverse effects can be increased when Imipramine is combined with Acepromazine.
IndalpineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Indalpine.
IndenololAcepromazine may increase the hypotensive activities of Indenolol.
IsocarboxazidThe risk or severity of adverse effects can be increased when Isocarboxazid is combined with Acepromazine.
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Acepromazine.
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Acepromazine.
KetazolamThe risk or severity of adverse effects can be increased when Ketazolam is combined with Acepromazine.
KetobemidoneAcepromazine may increase the hypotensive activities of Ketobemidone.
KetobemidoneThe risk or severity of adverse effects can be increased when Ketobemidone is combined with Acepromazine.
LabetalolAcepromazine may increase the hypotensive activities of Labetalol.
LamotrigineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Lamotrigine.
LevetiracetamThe risk or severity of adverse effects can be increased when Acepromazine is combined with Levetiracetam.
LevobunololAcepromazine may increase the hypotensive activities of Levobunolol.
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Acepromazine.
LevocabastineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Levocabastine.
LevocetirizineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Levocetirizine.
LevodopaThe risk or severity of adverse effects can be increased when Acepromazine is combined with Levodopa.
Levomethadyl AcetateAcepromazine may increase the hypotensive activities of Levomethadyl Acetate.
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Acepromazine.
LevomilnacipranThe risk or severity of adverse effects can be increased when Acepromazine is combined with Levomilnacipran.
LevorphanolAcepromazine may increase the hypotensive activities of Levorphanol.
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Acepromazine.
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Acepromazine.
LinezolidThe risk or severity of adverse effects can be increased when Linezolid is combined with Acepromazine.
LisdexamfetamineAcepromazine may decrease the stimulatory activities of Lisdexamfetamine.
LithiumLithium may increase the neurotoxic activities of Acepromazine.
LithiumThe risk or severity of adverse effects can be increased when Acepromazine is combined with Lithium.
LofentanilAcepromazine may increase the hypotensive activities of Lofentanil.
LofentanilThe risk or severity of adverse effects can be increased when Lofentanil is combined with Acepromazine.
LoratadineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Loratadine.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Acepromazine.
LorcaserinThe risk or severity of adverse effects can be increased when Lorcaserin is combined with Acepromazine.
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Acepromazine.
Lu AA21004The risk or severity of adverse effects can be increased when Acepromazine is combined with Lu AA21004.
LumefantrineThe serum concentration of Acepromazine can be increased when it is combined with Lumefantrine.
LurasidoneThe risk or severity of adverse effects can be increased when Acepromazine is combined with Lurasidone.
MagaldrateMagaldrate can cause a decrease in the absorption of Acepromazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium carbonateMagnesium carbonate can cause a decrease in the absorption of Acepromazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium hydroxideMagnesium hydroxide can cause a decrease in the absorption of Acepromazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium oxideMagnesium oxide can cause a decrease in the absorption of Acepromazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Acepromazine.
Magnesium SulfateThe risk or severity of adverse effects can be increased when Acepromazine is combined with Magnesium Sulfate.
Magnesium TrisilicateMagnesium Trisilicate can cause a decrease in the absorption of Acepromazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
MaprotilineThe risk or severity of adverse effects can be increased when Maprotiline is combined with Acepromazine.
MeclizineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Meclizine.
MedetomidineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Medetomidine.
MefloquineThe serum concentration of Acepromazine can be increased when it is combined with Mefloquine.
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Acepromazine.
MelperoneThe risk or severity of adverse effects can be increased when Acepromazine is combined with Melperone.
MephentermineAcepromazine may decrease the stimulatory activities of Mephentermine.
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Acepromazine.
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Acepromazine.
MequitazineAcepromazine may increase the arrhythmogenic activities of Mequitazine.
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Acepromazine.
MetaxaloneThe risk or severity of adverse effects can be increased when Acepromazine is combined with Metaxalone.
MethadoneAcepromazine may increase the hypotensive activities of Methadone.
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Acepromazine.
Methadyl AcetateAcepromazine may increase the hypotensive activities of Methadyl Acetate.
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Acepromazine.
MethamphetamineAcepromazine may decrease the stimulatory activities of Methamphetamine.
MethapyrileneThe risk or severity of adverse effects can be increased when Acepromazine is combined with Methapyrilene.
MethaqualoneThe risk or severity of adverse effects can be increased when Acepromazine is combined with Methaqualone.
MethocarbamolThe risk or severity of adverse effects can be increased when Acepromazine is combined with Methocarbamol.
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Acepromazine.
MethotrimeprazineThe risk or severity of adverse effects can be increased when Methotrimeprazine is combined with Acepromazine.
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Acepromazine.
MethsuximideThe risk or severity of adverse effects can be increased when Acepromazine is combined with Methsuximide.
MethylphenidateThe risk or severity of adverse effects can be increased when Acepromazine is combined with Methylphenidate.
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Acepromazine.
MetipranololAcepromazine may increase the hypotensive activities of Metipranolol.
MetoclopramideThe risk or severity of adverse effects can be increased when Metoclopramide is combined with Acepromazine.
MetoprololAcepromazine may increase the hypotensive activities of Metoprolol.
MetyrosineAcepromazine may increase the sedative activities of Metyrosine.
MetyrosineThe risk or severity of adverse effects can be increased when Metyrosine is combined with Acepromazine.
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Acepromazine.
MilnacipranThe risk or severity of adverse effects can be increased when Acepromazine is combined with Milnacipran.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Acepromazine.
MirtazapineAcepromazine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MirtazapineThe risk or severity of adverse effects can be increased when Mirtazapine is combined with Acepromazine.
MoclobemideThe risk or severity of adverse effects can be increased when Moclobemide is combined with Acepromazine.
MolindoneThe risk or severity of adverse effects can be increased when Acepromazine is combined with Molindone.
MorphineAcepromazine may increase the hypotensive activities of Morphine.
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Acepromazine.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Acepromazine.
NabiloneThe risk or severity of adverse effects can be increased when Acepromazine is combined with Nabilone.
NadololAcepromazine may increase the hypotensive activities of Nadolol.
NalbuphineAcepromazine may increase the hypotensive activities of Nalbuphine.
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Acepromazine.
NaratriptanThe risk or severity of adverse effects can be increased when Naratriptan is combined with Acepromazine.
NefazodoneThe risk or severity of adverse effects can be increased when Nefazodone is combined with Acepromazine.
NitrazepamThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Acepromazine.
Nitrous oxideThe risk or severity of adverse effects can be increased when Acepromazine is combined with Nitrous oxide.
NormethadoneAcepromazine may increase the hypotensive activities of Normethadone.
NormethadoneThe risk or severity of adverse effects can be increased when Normethadone is combined with Acepromazine.
NortriptylineThe risk or severity of adverse effects can be increased when Nortriptyline is combined with Acepromazine.
OlanzapineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Olanzapine.
OlopatadineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Olopatadine.
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Acepromazine.
OpiumAcepromazine may increase the hypotensive activities of Opium.
OpiumThe risk or severity of adverse effects can be increased when Opium is combined with Acepromazine.
OrphenadrineAcepromazine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
OrphenadrineThe risk or severity of adverse effects can be increased when Orphenadrine is combined with Acepromazine.
OsanetantThe risk or severity of adverse effects can be increased when Acepromazine is combined with Osanetant.
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Acepromazine.
OxprenololAcepromazine may increase the hypotensive activities of Oxprenolol.
OxprenololThe risk or severity of adverse effects can be increased when Oxprenolol is combined with Acepromazine.
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Acepromazine.
OxycodoneAcepromazine may increase the hypotensive activities of Oxycodone.
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Acepromazine.
OxymorphoneAcepromazine may increase the hypotensive activities of Oxymorphone.
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Acepromazine.
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Acepromazine.
ParaldehydeAcepromazine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParaldehydeThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Acepromazine.
ParoxetineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Paroxetine.
PenbutololAcepromazine may increase the hypotensive activities of Penbutolol.
PentazocineAcepromazine may increase the hypotensive activities of Pentazocine.
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Acepromazine.
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Acepromazine.
PerampanelThe risk or severity of adverse effects can be increased when Acepromazine is combined with Perampanel.
PerospironeThe risk or severity of adverse effects can be increased when Acepromazine is combined with Perospirone.
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Acepromazine.
PethidineAcepromazine may increase the hypotensive activities of Pethidine.
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Acepromazine.
PhenelzineThe risk or severity of adverse effects can be increased when Phenelzine is combined with Acepromazine.
PhenobarbitalThe risk or severity of adverse effects can be increased when Phenobarbital is combined with Acepromazine.
PhenoxyethanolThe risk or severity of adverse effects can be increased when Acepromazine is combined with Phenoxyethanol.
PhentermineAcepromazine may decrease the stimulatory activities of Phentermine.
PhenytoinThe risk or severity of adverse effects can be increased when Acepromazine is combined with Phenytoin.
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Acepromazine.
PindololAcepromazine may increase the hypotensive activities of Pindolol.
PipamperoneThe risk or severity of adverse effects can be increased when Acepromazine is combined with Pipamperone.
PipotiazineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Pipotiazine.
PizotifenThe risk or severity of adverse effects can be increased when Acepromazine is combined with Pizotifen.
PomalidomideThe risk or severity of adverse effects can be increased when Acepromazine is combined with Pomalidomide.
PractololAcepromazine may increase the hypotensive activities of Practolol.
PramipexoleAcepromazine may increase the sedative activities of Pramipexole.
PramocaineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Pramocaine.
PrazepamThe risk or severity of adverse effects can be increased when Prazepam is combined with Acepromazine.
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Acepromazine.
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Acepromazine.
PrimaquineThe serum concentration of Acepromazine can be increased when it is combined with Primaquine.
PrimidoneThe risk or severity of adverse effects can be increased when Acepromazine is combined with Primidone.
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Acepromazine.
ProcarbazineThe risk or severity of adverse effects can be increased when Procarbazine is combined with Acepromazine.
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Acepromazine.
ProguanilThe serum concentration of Acepromazine can be increased when it is combined with Proguanil.
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Acepromazine.
PromethazineThe risk or severity of adverse effects can be increased when Promethazine is combined with Acepromazine.
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Acepromazine.
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Acepromazine.
PropoxycaineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Propoxycaine.
PropranololAcepromazine may increase the hypotensive activities of Propranolol.
ProtriptylineThe risk or severity of adverse effects can be increased when Protriptyline is combined with Acepromazine.
PSD502The risk or severity of adverse effects can be increased when Acepromazine is combined with PSD502.
PyrimethamineThe serum concentration of Acepromazine can be increased when it is combined with Pyrimethamine.
QuazepamThe risk or severity of adverse effects can be increased when Quazepam is combined with Acepromazine.
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Acepromazine.
QuinacrineThe serum concentration of Acepromazine can be increased when it is combined with Quinacrine.
QuinagolideThe therapeutic efficacy of Quinagolide can be decreased when used in combination with Acepromazine.
QuinidineThe serum concentration of Acepromazine can be increased when it is combined with Quinidine.
QuinineThe serum concentration of Acepromazine can be increased when it is combined with Quinine.
RadicicolThe serum concentration of Acepromazine can be increased when it is combined with Radicicol.
RamelteonThe risk or severity of adverse effects can be increased when Acepromazine is combined with Ramelteon.
RasagilineThe risk or severity of adverse effects can be increased when Rasagiline is combined with Acepromazine.
RemifentanilAcepromazine may increase the hypotensive activities of Remifentanil.
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Acepromazine.
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Acepromazine.
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Acepromazine.
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Acepromazine.
RizatriptanThe risk or severity of adverse effects can be increased when Rizatriptan is combined with Acepromazine.
RomifidineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Romifidine.
RopiniroleAcepromazine may increase the sedative activities of Ropinirole.
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Acepromazine.
RotigotineAcepromazine may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Acepromazine.
S-EthylisothioureaThe risk or severity of adverse effects can be increased when Acepromazine is combined with S-Ethylisothiourea.
ScopolamineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Scopolamine.
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Acepromazine.
SelegilineThe risk or severity of adverse effects can be increased when Selegiline is combined with Acepromazine.
SertindoleThe risk or severity of adverse effects can be increased when Acepromazine is combined with Sertindole.
SertralineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Sertraline.
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Acepromazine.
SinefunginThe serum concentration of Acepromazine can be increased when it is combined with Sinefungin.
Sodium oxybateThe risk or severity of adverse effects can be increased when Acepromazine is combined with Sodium oxybate.
SotalolAcepromazine may increase the hypotensive activities of Sotalol.
StiripentolThe risk or severity of adverse effects can be increased when Acepromazine is combined with Stiripentol.
SufentanilAcepromazine may increase the hypotensive activities of Sufentanil.
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Acepromazine.
SulfadoxineThe serum concentration of Acepromazine can be increased when it is combined with Sulfadoxine.
SulfametopyrazineThe serum concentration of Acepromazine can be increased when it is combined with Sulfametopyrazine.
SulpirideThe risk or severity of adverse effects can be increased when Acepromazine is combined with Sulpiride.
SumatriptanThe risk or severity of adverse effects can be increased when Sumatriptan is combined with Acepromazine.
SuvorexantThe risk or severity of adverse effects can be increased when Acepromazine is combined with Suvorexant.
tafenoquineThe serum concentration of Acepromazine can be increased when it is combined with tafenoquine.
TapentadolAcepromazine may increase the hypotensive activities of Tapentadol.
TapentadolThe risk or severity of adverse effects can be increased when Tapentadol is combined with Acepromazine.
TasimelteonThe risk or severity of adverse effects can be increased when Acepromazine is combined with Tasimelteon.
Tedizolid PhosphateThe risk or severity of adverse effects can be increased when Tedizolid Phosphate is combined with Acepromazine.
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Acepromazine.
TetrabenazineThe risk or severity of adverse effects can be increased when Tetrabenazine is combined with Acepromazine.
TetracaineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Tetracaine.
TetrodotoxinThe risk or severity of adverse effects can be increased when Acepromazine is combined with Tetrodotoxin.
ThalidomideAcepromazine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
ThalidomideThe risk or severity of adverse effects can be increased when Thalidomide is combined with Acepromazine.
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Acepromazine.
ThiopentalThe risk or severity of adverse effects can be increased when Acepromazine is combined with Thiopental.
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Acepromazine.
ThiothixeneThe risk or severity of adverse effects can be increased when Acepromazine is combined with Thiothixene.
TiagabineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Tiagabine.
TiletamineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Tiletamine.
TimololAcepromazine may increase the hypotensive activities of Timolol.
TizanidineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Tizanidine.
TolcaponeThe risk or severity of adverse effects can be increased when Acepromazine is combined with Tolcapone.
TopiramateThe risk or severity of adverse effects can be increased when Acepromazine is combined with Topiramate.
TramadolAcepromazine may increase the hypotensive activities of Tramadol.
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Acepromazine.
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Trans-2-Phenylcyclopropylamine.
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Acepromazine.
TrazodoneThe risk or severity of adverse effects can be increased when Acepromazine is combined with Trazodone.
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Acepromazine.
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Acepromazine.
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Acepromazine.
TrimethoprimThe serum concentration of Acepromazine can be increased when it is combined with Trimethoprim.
TrimipramineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Acepromazine.
TriprolidineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Triprolidine.
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Acepromazine.
VenlafaxineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Acepromazine.
VigabatrinThe risk or severity of adverse effects can be increased when Acepromazine is combined with Vigabatrin.
VilazodoneThe risk or severity of adverse effects can be increased when Acepromazine is combined with Vilazodone.
VortioxetineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Vortioxetine.
XylazineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Xylazine.
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Acepromazine.
ZiconotideThe risk or severity of adverse effects can be increased when Acepromazine is combined with Ziconotide.
ZimelidineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Zimelidine.
ZiprasidoneThe risk or severity of adverse effects can be increased when Ziprasidone is combined with Acepromazine.
ZolazepamThe risk or severity of adverse effects can be increased when Acepromazine is combined with Zolazepam.
ZolmitriptanThe risk or severity of adverse effects can be increased when Zolmitriptan is combined with Acepromazine.
ZolpidemThe risk or severity of adverse effects can be increased when Zolpidem is combined with Acepromazine.
ZonisamideThe risk or severity of adverse effects can be increased when Acepromazine is combined with Zonisamide.
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Acepromazine.
ZotepineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Zotepine.
ZuclopenthixolThe risk or severity of adverse effects can be increased when Acepromazine is combined with Zuclopenthixol.
Food Interactions
  • Avoid alcohol
  • Take with food to reduce irritation

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Potassium channel regulator activity
Specific Function:
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.
Gene Name:
DRD2
Uniprot ID:
P14416
Molecular Weight:
50618.91 Da
References
  1. Oades RD, Rao ML, Bender S, Sartory G, Muller BW: Neuropsychological and conditioned blocking performance in patients with schizophrenia: assessment of the contribution of neuroleptic dose, serum levels and dopamine D2-receptor occupancy. Behav Pharmacol. 2000 Jun;11(3-4):317-30. [PubMed:11103886 ]
  2. Seeman P: Atypical antipsychotics: mechanism of action. Can J Psychiatry. 2002 Feb;47(1):27-38. [PubMed:11873706 ]
  3. Wu S, Xing Q, Gao R, Li X, Gu N, Feng G, He L: Response to chlorpromazine treatment may be associated with polymorphisms of the DRD2 gene in Chinese schizophrenic patients. Neurosci Lett. 2005 Mar 7;376(1):1-4. Epub 2004 Dec 2. [PubMed:15694263 ]
  4. Wu SN, Gao R, Xing QH, Li HF, Shen YF, Gu NF, Feng GY, He L: Association of DRD2 polymorphisms and chlorpromazine-induced extrapyramidal syndrome in Chinese schizophrenic patients. Acta Pharmacol Sin. 2006 Aug;27(8):966-70. [PubMed:16867246 ]
  5. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  6. Seeman P: Dopamine D2 receptors as treatment targets in schizophrenia. Clin Schizophr Relat Psychoses. 2010 Apr;4(1):56-73. doi: 10.3371/CSRP.4.1.5. [PubMed:20643630 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
G-protein coupled amine receptor activity
Specific Function:
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
Gene Name:
DRD1
Uniprot ID:
P21728
Molecular Weight:
49292.765 Da
References
  1. Kanba S, Suzuki E, Nomura S, Nakaki T, Yagi G, Asai M, Richelson E: Affinity of neuroleptics for D1 receptor of human brain striatum. J Psychiatry Neurosci. 1994 Jul;19(4):265-9. [PubMed:7918347 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Virus receptor activity
Specific Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates...
Gene Name:
HTR2A
Uniprot ID:
P28223
Molecular Weight:
52602.58 Da
References
  1. Kusumi I, Takahashi Y, Suzuki K, Kameda K, Koyama T: Differential effects of subchronic treatments with atypical antipsychotic drugs on dopamine D2 and serotonin 5-HT2A receptors in the rat brain. J Neural Transm (Vienna). 2000;107(3):295-302. [PubMed:10821438 ]
  2. Yamada J, Sugimoto Y, Horisaka K: Serotonin2 (5-HT2) receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) inhibits chlorpromazine- and haloperidol-induced hypothermia in mice. Biol Pharm Bull. 1995 Nov;18(11):1580-3. [PubMed:8593484 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Serotonin receptor activity
Specific Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G pro...
Gene Name:
HTR1A
Uniprot ID:
P08908
Molecular Weight:
46106.335 Da
References
  1. Cosi C, Koek W: Agonist, antagonist, and inverse agonist properties of antipsychotics at human recombinant 5-HT(1A) receptors expressed in HeLa cells. Eur J Pharmacol. 2001 Dec 14;433(1):55-62. [PubMed:11755134 ]
  2. Newman-Tancredi A, Gavaudan S, Conte C, Chaput C, Touzard M, Verriele L, Audinot V, Millan MJ: Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study. Eur J Pharmacol. 1998 Aug 21;355(2-3):245-56. [PubMed:9760039 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Protein heterodimerization activity
Specific Function:
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
Gene Name:
ADRA1A
Uniprot ID:
P35348
Molecular Weight:
51486.005 Da
References
  1. Cahir M, King DJ: Antipsychotics lack alpha 1A/B adrenoceptor subtype selectivity in the rat. Eur Neuropsychopharmacol. 2005 Mar;15(2):231-4. [PubMed:15695070 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Protein heterodimerization activity
Specific Function:
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
Gene Name:
ADRA1B
Uniprot ID:
P35368
Molecular Weight:
56835.375 Da
References
  1. Cahir M, King DJ: Antipsychotics lack alpha 1A/B adrenoceptor subtype selectivity in the rat. Eur Neuropsychopharmacol. 2005 Mar;15(2):231-4. [PubMed:15695070 ]

Carriers

Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Toxic substance binding
Specific Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
Gene Name:
ALB
Uniprot ID:
P02768
Molecular Weight:
69365.94 Da
References
  1. Kitamura K, Omran AA, Nagata C, Kamijima Y, Tanaka R, Takegami S, Kitade T: Effects of inorganic ions on the binding of triflupromazine and chlorpromazine to bovine serum albumin studied by spectrometric methods. Chem Pharm Bull (Tokyo). 2006 Jul;54(7):972-6. [PubMed:16819214 ]
  2. Rukhadze MD, Bezarashvili GS, Sidamonidze NS, Tsagareli SK: Investigation of binding process of chlorpromazine to bovine serum albumin by means of passive and active experiments. Biomed Chromatogr. 2001 Oct;15(6):365-73. [PubMed:11559920 ]
  3. Silva D, Cortez CM, Louro SR: Quenching of the intrinsic fluorescence of bovine serum albumin by chlorpromazine and hemin. Braz J Med Biol Res. 2004 Jul;37(7):963-8. Epub 2004 Jun 22. [PubMed:15264002 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Secondary active organic cation transmembrane transporter activity
Specific Function:
Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine...
Gene Name:
SLC22A1
Uniprot ID:
O15245
Molecular Weight:
61153.345 Da
References
  1. Bednarczyk D, Ekins S, Wikel JH, Wright SH: Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1. Mol Pharmacol. 2003 Mar;63(3):489-98. [PubMed:12606755 ]
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Drug created on August 29, 2007 14:12 / Updated on August 17, 2016 12:23