You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on DrugBank.
Identification
NameColforsin
Accession NumberDB02587  (EXPT01467)
TypeSmall Molecule
GroupsExperimental
DescriptionPotent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant Coleus forskohlii. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland. [PubChem]
Structure
Thumb
Synonyms
Forskolin
External Identifiers
  • 266-410-9
  • HL-362
  • L-75-1362B
  • NSC-357088
  • NSC-375489
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNII1F7A44V6OU
CAS number66575-29-9
WeightAverage: 410.5012
Monoisotopic: 410.230453442
Chemical FormulaC22H34O7
InChI KeyInChIKey=OHCQJHSOBUTRHG-KGGHGJDLSA-N
InChI
InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1
IUPAC Name
(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-dodecahydro-1H-naphtho[2,1-b]pyran-5-yl acetate
SMILES
[H][C@]1(O)CCC(C)(C)[C@]2([H])[C@]([H])(O)[C@]([H])(OC(C)=O)[C@@]3(C)O[C@](C)(CC(=O)[C@]3(O)[C@@]12C)C=C
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as naphthopyrans. These are compounds containing a pyran ring fused to a naphthalene moiety. Furan is a 6 membered-ring non-aromatic ring with five carbon and one oxygen atoms. Naphthalene is a polycyclic aromatic hydrocarbon made up of two fused benzene rings.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassNaphthopyrans
Sub ClassNot Available
Direct ParentNaphthopyrans
Alternative Parents
Substituents
  • Naphthopyran
  • Naphthalene
  • Pyran
  • Oxane
  • Acetate salt
  • Tertiary alcohol
  • Cyclic alcohol
  • Secondary alcohol
  • Polyol
  • Ketone
  • Carboxylic acid ester
  • Oxacycle
  • Ether
  • Dialkyl ether
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Alcohol
  • Aliphatic heteropolycyclic compound
Molecular FrameworkAliphatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationNot Available
PharmacodynamicsNot Available
Mechanism of actionNot Available
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organismsNot Available
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.6195
Blood Brain Barrier+0.6888
Caco-2 permeable-0.6796
P-glycoprotein substrateSubstrate0.8361
P-glycoprotein inhibitor IInhibitor0.8198
P-glycoprotein inhibitor IIInhibitor0.6788
Renal organic cation transporterNon-inhibitor0.8998
CYP450 2C9 substrateNon-substrate0.7961
CYP450 2D6 substrateNon-substrate0.892
CYP450 3A4 substrateSubstrate0.7016
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorNon-inhibitor0.935
CYP450 2C19 inhibitorNon-inhibitor0.9026
CYP450 3A4 inhibitorInhibitor0.7959
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9606
Ames testNon AMES toxic0.6284
CarcinogenicityNon-carcinogens0.9539
BiodegradationNot ready biodegradable0.9792
Rat acute toxicity2.2384 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9911
hERG inhibition (predictor II)Non-inhibitor0.8782
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental PropertiesNot Available
Predicted Properties
PropertyValueSource
Water Solubility1.1 mg/mLALOGPS
logP1.28ALOGPS
logP1.36ChemAxon
logS-2.6ALOGPS
pKa (Strongest Acidic)11.57ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area113.29 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity104.47 m3·mol-1ChemAxon
Polarizability43.33 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

Emiko Yamasaki, Takaaki Ohkuma, “Lyophilized preparation of 6-(3-dimethylaminopropionyl)forskolin.” U.S. Patent US5051132, issued June, 1974.

US5051132
General ReferencesNot Available
External Links
ATC CodesNot Available
AHFS CodesNot Available
PDB Entries
FDA labelNot Available
MSDSNot Available
Interactions
Drug Interactions
Drug
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Colforsin.
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Colforsin.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Colforsin.
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Colforsin.
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Colforsin.
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Colforsin.
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Colforsin.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Colforsin.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Colforsin.
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Colforsin.
AtazanavirThe serum concentration of Atazanavir can be increased when it is combined with Colforsin.
AtenololThe serum concentration of Atenolol can be increased when it is combined with Colforsin.
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Colforsin.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Colforsin.
BoceprevirThe serum concentration of Boceprevir can be increased when it is combined with Colforsin.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Colforsin.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Colforsin.
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Colforsin.
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Colforsin.
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Colforsin.
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Colforsin.
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Colforsin.
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Colforsin.
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Colforsin.
CeritinibThe serum concentration of Ceritinib can be increased when it is combined with Colforsin.
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Colforsin.
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Colforsin.
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Colforsin.
CiprofloxacinThe serum concentration of Ciprofloxacin can be increased when it is combined with Colforsin.
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Colforsin.
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Colforsin.
ClarithromycinThe serum concentration of Clarithromycin can be increased when it is combined with Colforsin.
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Colforsin.
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Colforsin.
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Colforsin.
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Colforsin.
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Colforsin.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Colforsin.
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Colforsin.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Colforsin.
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Colforsin.
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Colforsin.
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be increased when it is combined with Colforsin.
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Colforsin.
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Colforsin.
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Colforsin.
DasatinibThe serum concentration of Dasatinib can be increased when it is combined with Colforsin.
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Colforsin.
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Colforsin.
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Colforsin.
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Colforsin.
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Colforsin.
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Colforsin.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Colforsin.
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Colforsin.
DiltiazemThe serum concentration of Diltiazem can be increased when it is combined with Colforsin.
DipyridamoleThe serum concentration of Dipyridamole can be increased when it is combined with Colforsin.
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Colforsin.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Colforsin.
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Colforsin.
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Colforsin.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Colforsin.
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Colforsin.
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Colforsin.
ErythromycinThe serum concentration of Erythromycin can be increased when it is combined with Colforsin.
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Colforsin.
EstriolThe serum concentration of Estriol can be increased when it is combined with Colforsin.
EstroneThe serum concentration of Estrone can be increased when it is combined with Colforsin.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Colforsin.
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Colforsin.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Colforsin.
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Colforsin.
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Colforsin.
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Colforsin.
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Colforsin.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Colforsin.
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Colforsin.
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Colforsin.
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Colforsin.
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Colforsin.
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Colforsin.
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Colforsin.
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Colforsin.
IdelalisibThe serum concentration of Idelalisib can be increased when it is combined with Colforsin.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Colforsin.
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Colforsin.
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Colforsin.
IndinavirThe serum concentration of Indinavir can be increased when it is combined with Colforsin.
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Colforsin.
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Colforsin.
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Colforsin.
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Colforsin.
KetoconazoleThe serum concentration of Ketoconazole can be increased when it is combined with Colforsin.
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Colforsin.
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Colforsin.
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Colforsin.
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Colforsin.
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Colforsin.
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Colforsin.
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Colforsin.
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Colforsin.
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Colforsin.
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Colforsin.
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Colforsin.
LosartanThe serum concentration of Losartan can be increased when it is combined with Colforsin.
MannitolThe serum concentration of Mannitol can be increased when it is combined with Colforsin.
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Colforsin.
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Colforsin.
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Colforsin.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Colforsin.
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Colforsin.
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Colforsin.
MorphineThe serum concentration of Morphine can be increased when it is combined with Colforsin.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Colforsin.
NadololThe serum concentration of Nadolol can be increased when it is combined with Colforsin.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Colforsin.
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Colforsin.
NelfinavirThe serum concentration of Nelfinavir can be increased when it is combined with Colforsin.
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Colforsin.
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Colforsin.
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Colforsin.
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Colforsin.
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Colforsin.
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Colforsin.
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Colforsin.
OsimertinibThe serum concentration of Osimertinib can be increased when it is combined with Colforsin.
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Colforsin.
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Colforsin.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Colforsin.
PhenobarbitalThe serum concentration of Phenobarbital can be increased when it is combined with Colforsin.
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Colforsin.
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Colforsin.
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Colforsin.
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Colforsin.
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Colforsin.
PrazosinThe serum concentration of Prazosin can be increased when it is combined with Colforsin.
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Colforsin.
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Colforsin.
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Colforsin.
PropranololThe serum concentration of Propranolol can be increased when it is combined with Colforsin.
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Colforsin.
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Colforsin.
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Colforsin.
QuinineThe serum concentration of Quinine can be increased when it is combined with Colforsin.
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Colforsin.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Colforsin.
ReserpineThe serum concentration of Reserpine can be increased when it is combined with Colforsin.
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Colforsin.
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Colforsin.
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Colforsin.
RitonavirThe serum concentration of Ritonavir can be increased when it is combined with Colforsin.
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Colforsin.
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Colforsin.
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Colforsin.
SaquinavirThe serum concentration of Saquinavir can be increased when it is combined with Colforsin.
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Colforsin.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Colforsin.
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Colforsin.
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Colforsin.
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Colforsin.
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Colforsin.
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Colforsin.
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Colforsin.
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Colforsin.
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Colforsin.
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Colforsin.
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Colforsin.
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Colforsin.
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Colforsin.
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Colforsin.
TimololThe serum concentration of Timolol can be increased when it is combined with Colforsin.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Colforsin.
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Colforsin.
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Colforsin.
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Colforsin.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Colforsin.
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Colforsin.
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Colforsin.
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Colforsin.
VerapamilThe serum concentration of Verapamil can be increased when it is combined with Colforsin.
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Colforsin.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Colforsin.
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Colforsin.
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Colforsin.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Protein heterodimerization activity
Specific Function:
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity).
Gene Name:
ADCY2
Uniprot ID:
Q08462
Molecular Weight:
123602.25 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Signal transducer activity
Specific Function:
Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) (PubMed:17110384). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:26206488, PubMed:8702665). GNAS functions downstream of several GPCRs, including beta-adrenergic re...
Gene Name:
GNAS
Uniprot ID:
P63092
Molecular Weight:
45664.205 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Protein heterodimerization activity
Specific Function:
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642, PubMed:26206488, PubMed:24700542). Mediates signaling downstream of ADRB1 (PubMed:24700542). Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (PubMed:24740569).
Gene Name:
ADCY5
Uniprot ID:
O95622
Molecular Weight:
138906.37 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. [PubMed:11716514 ]
Comments
comments powered by Disqus
Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23