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Identification
NameAldosterone
Accession NumberDB04630
TypeSmall Molecule
GroupsExperimental
DescriptionA hormone secreted by the adrenal cortex that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium. [PubChem]
Structure
Thumb
Synonyms
(+)-aldosterone
11beta,21-Dihydroxy-3,20-diketo-4-pregnen-18-al
11beta,21-Dihydroxy-3,20-diketopregn-4-ene-18-al
11beta,21-dihydroxy-3,20-dioxo-4-pregnen-18-al
11beta,21-dihydroxy-3,20-dioxo-pregn-4-ene-18-al
11beta,21-dihydroxy-3,20-dioxopregn-4-en-18-al
11beta,21-Dihydroxypregn-4-ene-3,18,20-trione
18-Aldocorticosterone
18-Formyl-11beta,21-dihydroxy-4-pregnene-3,20-dione
18-Oxocorticosterone
Aldocorten
Aldocortene
Aldocortin
Aldosterona
Aldosteronum
D-aldosterone
Electrocortin
Elektrocortin
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNII4964P6T9RB
CAS number52-39-1
WeightAverage: 360.444
Monoisotopic: 360.193674006
Chemical FormulaC21H28O5
InChI KeyInChIKey=PQSUYGKTWSAVDQ-ZVIOFETBSA-N
InChI
InChI=1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1
IUPAC Name
(1S,2R,10S,11S,14S,15R,17S)-17-hydroxy-14-(2-hydroxyacetyl)-2-methyl-5-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-ene-15-carbaldehyde
SMILES
[H][C@@]1(CC[C@@]2([H])[C@]3([H])CCC4=CC(=O)CC[C@]4(C)[C@@]3([H])[C@@]([H])(O)C[C@]12C=O)C(=O)CO
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassSteroids and steroid derivatives
Sub ClassHydroxysteroids
Direct Parent21-hydroxysteroids
Alternative Parents
Substituents
  • 21-hydroxysteroid
  • Progestogin-skeleton
  • Pregnane-skeleton
  • 20-oxosteroid
  • 18-oxosteroid
  • 11-hydroxysteroid
  • 11-beta-hydroxysteroid
  • Oxosteroid
  • 3-oxosteroid
  • 3-oxo-delta-4-steroid
  • Delta-4-steroid
  • Cyclic alcohol
  • Alpha-hydroxy ketone
  • Cyclic ketone
  • Secondary alcohol
  • Ketone
  • Hydrocarbon derivative
  • Primary alcohol
  • Organooxygen compound
  • Carbonyl group
  • Aldehyde
  • Alcohol
  • Aliphatic homopolycyclic compound
Molecular FrameworkAliphatic homopolycyclic compounds
External Descriptors
Pharmacology
IndicationNot Available
PharmacodynamicsAt the late distal tubule and collecting duct, aldosterone has two main actions: 1) aldosterone acts on mineralocorticoid receptors (MR) on principal cells in the distal tubule of the kidney nephron, increasing the permeability of their apical (luminal) membrane to potassium and sodium and activates their basolateral Na+/K+ pumps, stimulating ATP hydrolysis leading to phosphorylation of the pump and a conformational change in the pump exposes the Na+ ions to the outside. The phosphorylated form of the pump has a low affinity for Na+ ions, hence reabsorbing sodium (Na+) ions and water into the blood, and secreting potassium (K+) ions into the urine; 2) aldosterone stimulates H+ secretion by intercalated cells in the collecting duct, regulating plasma bicarbonate (HCO3−) levels and its acid/base balance; and 3) aldosterone may act on the central nervous system via the posterior pituitary gland to release vasopressin (ADH) which serves to conserve water by direct actions on renal tubular resorption.
Mechanism of actionNot Available
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
Metabolism
SubstrateEnzymesProduct
Aldosterone
Not Available
Aldosterone 18-glucuronideDetails
Aldosterone
Not Available
Tetrahydroaldosterone-3-glucuronideDetails
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9943
Blood Brain Barrier+0.921
Caco-2 permeable+0.8527
P-glycoprotein substrateSubstrate0.7719
P-glycoprotein inhibitor INon-inhibitor0.738
P-glycoprotein inhibitor IINon-inhibitor0.7441
Renal organic cation transporterNon-inhibitor0.6832
CYP450 2C9 substrateNon-substrate0.8059
CYP450 2D6 substrateNon-substrate0.904
CYP450 3A4 substrateSubstrate0.7278
CYP450 1A2 substrateNon-inhibitor0.9046
CYP450 2C9 inhibitorNon-inhibitor0.9189
CYP450 2D6 inhibitorNon-inhibitor0.9251
CYP450 2C19 inhibitorNon-inhibitor0.9434
CYP450 3A4 inhibitorNon-inhibitor0.8795
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8737
Ames testNon AMES toxic0.9073
CarcinogenicityNon-carcinogens0.9543
BiodegradationNot ready biodegradable0.9279
Rat acute toxicity1.5456 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9242
hERG inhibition (predictor II)Non-inhibitor0.5136
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point166.5 °CPhysProp
water solubility51.2 mg/L (at 37 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP1.08HANSCH,C ET AL. (1995)
Predicted Properties
PropertyValueSource
Water Solubility0.148 mg/mLALOGPS
logP1.54ALOGPS
logP1.06ChemAxon
logS-3.4ALOGPS
pKa (Strongest Acidic)13.82ChemAxon
pKa (Strongest Basic)-2.9ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area91.67 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity96.79 m3·mol-1ChemAxon
Polarizability38.87 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (12.2 KB)
SpectraNot Available
References
Synthesis Reference

Jack Fishman, Elliot Hahn, Gregory A. Smith, “Aldosterone biosynthesis inhibitor.” U.S. Patent US5120724, issued December, 1969.

US5120724
General References
  1. Williams JS, Williams GH: 50th anniversary of aldosterone. J Clin Endocrinol Metab. 2003 Jun;88(6):2364-72. [PubMed:12788829 ]
External Links
ATC CodesH02AA01
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (68.4 KB)
Interactions
Drug Interactions
Drug
1,10-PhenanthrolineThe risk or severity of adverse effects can be increased when Aldosterone is combined with 1,10-Phenanthroline.
AcebutololThe serum concentration of Acebutolol can be decreased when it is combined with Aldosterone.
AcetaminophenThe serum concentration of Acetaminophen can be decreased when it is combined with Aldosterone.
AcetaminophenThe serum concentration of Aldosterone can be increased when it is combined with Acetaminophen.
Acetylsalicylic acidThe risk or severity of adverse effects can be increased when Acetylsalicylic acid is combined with Aldosterone.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be decreased when it is combined with Aldosterone.
AfatinibThe serum concentration of Afatinib can be decreased when it is combined with Aldosterone.
AfatinibThe serum concentration of Aldosterone can be increased when it is combined with Afatinib.
AlbendazoleThe serum concentration of Aldosterone can be increased when it is combined with Albendazole.
AldesleukinAldosterone may decrease the antineoplastic activities of Aldesleukin.
AlectinibThe serum concentration of Aldosterone can be increased when it is combined with Alectinib.
AlfentanilThe serum concentration of Aldosterone can be increased when it is combined with Alfentanil.
AlitretinoinThe serum concentration of Alitretinoin can be decreased when it is combined with Aldosterone.
Aluminum hydroxideThe bioavailability of Aldosterone can be decreased when combined with Aluminum hydroxide.
Aluminum phosphateThe bioavailability of Aldosterone can be decreased when combined with Aluminum phosphate.
AmantadineThe serum concentration of Aldosterone can be increased when it is combined with Amantadine.
AmbenoniumThe risk or severity of adverse effects can be increased when Aldosterone is combined with Ambenonium.
AmbrisentanThe serum concentration of Ambrisentan can be decreased when it is combined with Aldosterone.
Aminohippuric acidThe serum concentration of Aldosterone can be increased when it is combined with Aminohippuric acid.
Aminosalicylic AcidThe risk or severity of adverse effects can be increased when Aminosalicylic Acid is combined with Aldosterone.
AmiodaroneThe serum concentration of Aldosterone can be decreased when it is combined with Amiodarone.
AmitriptylineThe serum concentration of Amitriptyline can be decreased when it is combined with Aldosterone.
AmitriptylineThe serum concentration of Aldosterone can be increased when it is combined with Amitriptyline.
AmlodipineThe serum concentration of Aldosterone can be increased when it is combined with Amlodipine.
Amphotericin BAldosterone may increase the hypokalemic activities of Amphotericin B.
AmprenavirThe serum concentration of Aldosterone can be decreased when it is combined with Amprenavir.
AmsacrineThe serum concentration of Aldosterone can be increased when it is combined with Amsacrine.
ApixabanThe serum concentration of Apixaban can be decreased when it is combined with Aldosterone.
AprepitantThe serum concentration of Aldosterone can be increased when it is combined with Aprepitant.
Arsenic trioxideThe serum concentration of Arsenic trioxide can be decreased when it is combined with Aldosterone.
AstemizoleThe serum concentration of Aldosterone can be increased when it is combined with Astemizole.
AtazanavirThe serum concentration of Atazanavir can be decreased when it is combined with Aldosterone.
AtazanavirThe serum concentration of Aldosterone can be increased when it is combined with Atazanavir.
AtenololThe serum concentration of Atenolol can be decreased when it is combined with Aldosterone.
AtenololThe serum concentration of Aldosterone can be increased when it is combined with Atenolol.
AtorvastatinThe serum concentration of Aldosterone can be increased when it is combined with Atorvastatin.
Atracurium besylateAtracurium besylate may increase the adverse neuromuscular activities of Aldosterone.
AxitinibThe serum concentration of Axitinib can be decreased when it is combined with Aldosterone.
AzelastineThe serum concentration of Aldosterone can be increased when it is combined with Azelastine.
AzithromycinThe serum concentration of Aldosterone can be increased when it is combined with Azithromycin.
BazedoxifeneThe serum concentration of Aldosterone can be increased when it is combined with Bazedoxifene.
BendroflumethiazideAldosterone may increase the hypokalemic activities of Bendroflumethiazide.
BenzocaineThe serum concentration of Aldosterone can be increased when it is combined with Benzocaine.
Benzoic AcidThe therapeutic efficacy of Benzoic Acid can be decreased when used in combination with Aldosterone.
BepridilThe serum concentration of Aldosterone can be increased when it is combined with Bepridil.
BetamethasoneThe serum concentration of Betamethasone can be decreased when it is combined with Aldosterone.
BiperidenThe serum concentration of Aldosterone can be increased when it is combined with Biperiden.
Bismuth SubcitrateThe bioavailability of Aldosterone can be decreased when combined with Bismuth Subcitrate.
BoceprevirThe serum concentration of Boceprevir can be decreased when it is combined with Aldosterone.
BoceprevirThe serum concentration of Aldosterone can be increased when it is combined with Boceprevir.
BosutinibThe serum concentration of Bosutinib can be decreased when it is combined with Aldosterone.
BosutinibThe serum concentration of Aldosterone can be increased when it is combined with Bosutinib.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be decreased when it is combined with Aldosterone.
BromocriptineThe serum concentration of Bromocriptine can be decreased when it is combined with Aldosterone.
BromocriptineThe serum concentration of Aldosterone can be increased when it is combined with Bromocriptine.
BumetanideAldosterone may increase the hypokalemic activities of Bumetanide.
BuprenorphineThe serum concentration of Aldosterone can be increased when it is combined with Buprenorphine.
BuspironeThe serum concentration of Aldosterone can be increased when it is combined with Buspirone.
CabazitaxelThe serum concentration of Cabazitaxel can be decreased when it is combined with Aldosterone.
CabazitaxelThe serum concentration of Aldosterone can be increased when it is combined with Cabazitaxel.
CaffeineThe serum concentration of Caffeine can be decreased when it is combined with Aldosterone.
CaffeineThe serum concentration of Aldosterone can be increased when it is combined with Caffeine.
CalcitriolThe therapeutic efficacy of Calcitriol can be decreased when used in combination with Aldosterone.
Calcium carbonateThe bioavailability of Aldosterone can be decreased when combined with Calcium carbonate.
CamptothecinThe serum concentration of Camptothecin can be decreased when it is combined with Aldosterone.
CanagliflozinThe serum concentration of Canagliflozin can be decreased when it is combined with Aldosterone.
CanagliflozinThe serum concentration of Aldosterone can be increased when it is combined with Canagliflozin.
CandesartanThe serum concentration of Aldosterone can be increased when it is combined with Candesartan.
CaptoprilThe serum concentration of Aldosterone can be increased when it is combined with Captopril.
CarbamazepineThe serum concentration of Aldosterone can be decreased when it is combined with Carbamazepine.
CarfilzomibThe serum concentration of Carfilzomib can be decreased when it is combined with Aldosterone.
CarvedilolThe serum concentration of Aldosterone can be increased when it is combined with Carvedilol.
CaspofunginThe serum concentration of Aldosterone can be increased when it is combined with Caspofungin.
CeritinibAldosterone may increase the hyperglycemic activities of Ceritinib.
CeritinibThe serum concentration of Aldosterone can be increased when it is combined with Ceritinib.
CerivastatinThe serum concentration of Cerivastatin can be decreased when it is combined with Aldosterone.
ChloroquineThe serum concentration of Aldosterone can be increased when it is combined with Chloroquine.
ChlorothiazideAldosterone may increase the hypokalemic activities of Chlorothiazide.
ChlorotrianiseneThe serum concentration of Aldosterone can be increased when it is combined with Chlorotrianisene.
ChlorpromazineThe serum concentration of Chlorpromazine can be decreased when it is combined with Aldosterone.
ChlorpromazineThe serum concentration of Aldosterone can be increased when it is combined with Chlorpromazine.
ChlorpropamideThe serum concentration of Aldosterone can be increased when it is combined with Chlorpropamide.
ChlorprothixeneThe serum concentration of Aldosterone can be increased when it is combined with Chlorprothixene.
ChlorthalidoneAldosterone may increase the hypokalemic activities of Chlorthalidone.
CholesterolThe serum concentration of Aldosterone can be increased when it is combined with Cholesterol.
CholestyramineCholestyramine can cause a decrease in the absorption of Aldosterone resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cholic AcidThe serum concentration of Aldosterone can be decreased when it is combined with Cholic Acid.
CilazaprilThe serum concentration of Aldosterone can be increased when it is combined with Cilazapril.
CimetidineThe serum concentration of Aldosterone can be decreased when it is combined with Cimetidine.
CiprofloxacinThe serum concentration of Ciprofloxacin can be decreased when it is combined with Aldosterone.
CiprofloxacinThe serum concentration of Aldosterone can be increased when it is combined with Ciprofloxacin.
CisplatinThe serum concentration of Cisplatin can be decreased when it is combined with Aldosterone.
CitalopramThe serum concentration of Citalopram can be decreased when it is combined with Aldosterone.
CitalopramThe serum concentration of Aldosterone can be increased when it is combined with Citalopram.
ClarithromycinThe serum concentration of Clarithromycin can be decreased when it is combined with Aldosterone.
ClarithromycinThe serum concentration of Aldosterone can be increased when it is combined with Clarithromycin.
ClobazamThe serum concentration of Clobazam can be decreased when it is combined with Aldosterone.
ClofazimineThe serum concentration of Aldosterone can be increased when it is combined with Clofazimine.
ClomifeneThe serum concentration of Clomifene can be decreased when it is combined with Aldosterone.
ClomipramineThe serum concentration of Aldosterone can be increased when it is combined with Clomipramine.
ClonidineThe serum concentration of Clonidine can be decreased when it is combined with Aldosterone.
ClopidogrelThe serum concentration of Clopidogrel can be decreased when it is combined with Aldosterone.
ClotrimazoleThe serum concentration of Aldosterone can be decreased when it is combined with Clotrimazole.
ClozapineThe serum concentration of Clozapine can be decreased when it is combined with Aldosterone.
CobicistatThe serum concentration of Aldosterone can be increased when it is combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be decreased when it is combined with Aldosterone.
ColchicineThe serum concentration of Colchicine can be decreased when it is combined with Aldosterone.
ColchicineThe serum concentration of Aldosterone can be increased when it is combined with Colchicine.
ColesevelamColesevelam can cause a decrease in the absorption of Aldosterone resulting in a reduced serum concentration and potentially a decrease in efficacy.
ColestipolColestipol can cause a decrease in the absorption of Aldosterone resulting in a reduced serum concentration and potentially a decrease in efficacy.
ColforsinThe serum concentration of Aldosterone can be increased when it is combined with Colforsin.
Conjugated Equine EstrogensThe serum concentration of Aldosterone can be increased when it is combined with Conjugated Equine Estrogens.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be decreased when it is combined with Aldosterone.
Corticorelin ovine triflutateThe therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Aldosterone.
CoumaphosThe risk or severity of adverse effects can be increased when Aldosterone is combined with Coumaphos.
CrizotinibThe serum concentration of Crizotinib can be decreased when it is combined with Aldosterone.
CrizotinibThe serum concentration of Aldosterone can be increased when it is combined with Crizotinib.
CyclophosphamideThe serum concentration of Aldosterone can be increased when it is combined with Cyclophosphamide.
CyclosporineThe serum concentration of Aldosterone can be decreased when it is combined with Cyclosporine.
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be decreased when it is combined with Aldosterone.
DabrafenibThe serum concentration of Dabrafenib can be decreased when it is combined with Aldosterone.
DaclatasvirThe serum concentration of Aldosterone can be increased when it is combined with Daclatasvir.
DactinomycinThe serum concentration of Dactinomycin can be decreased when it is combined with Aldosterone.
DactinomycinThe serum concentration of Aldosterone can be increased when it is combined with Dactinomycin.
DapagliflozinThe serum concentration of Dapagliflozin can be decreased when it is combined with Aldosterone.
DarunavirThe serum concentration of Aldosterone can be increased when it is combined with Darunavir.
DasatinibThe serum concentration of Dasatinib can be decreased when it is combined with Aldosterone.
DasatinibThe serum concentration of Aldosterone can be increased when it is combined with Dasatinib.
DaunorubicinThe serum concentration of Daunorubicin can be decreased when it is combined with Aldosterone.
DebrisoquinThe serum concentration of Debrisoquin can be decreased when it is combined with Aldosterone.
DecamethoniumThe risk or severity of adverse effects can be increased when Aldosterone is combined with Decamethonium.
DeferasiroxThe risk or severity of adverse effects can be increased when Aldosterone is combined with Deferasirox.
DemecariumThe risk or severity of adverse effects can be increased when Aldosterone is combined with Demecarium.
DesipramineThe serum concentration of Aldosterone can be increased when it is combined with Desipramine.
DesloratadineThe serum concentration of Aldosterone can be increased when it is combined with Desloratadine.
DexamethasoneThe serum concentration of Aldosterone can be decreased when it is combined with Dexamethasone.
DextromethorphanThe serum concentration of Aldosterone can be increased when it is combined with Dextromethorphan.
DiazepamThe serum concentration of Diazepam can be decreased when it is combined with Aldosterone.
DichlorvosThe risk or severity of adverse effects can be increased when Aldosterone is combined with Dichlorvos.
DiclofenacThe serum concentration of Aldosterone can be increased when it is combined with Diclofenac.
DienestrolThe serum concentration of Aldosterone can be increased when it is combined with Dienestrol.
DiethylstilbestrolThe serum concentration of Aldosterone can be increased when it is combined with Diethylstilbestrol.
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be decreased when it is combined with Aldosterone.
DiflunisalThe risk or severity of adverse effects can be increased when Diflunisal is combined with Aldosterone.
DigitoxinThe serum concentration of Digitoxin can be decreased when it is combined with Aldosterone.
DigoxinThe serum concentration of Aldosterone can be decreased when it is combined with Digoxin.
DihydroergotamineThe serum concentration of Aldosterone can be increased when it is combined with Dihydroergotamine.
DihydrotestosteroneAldosterone may increase the fluid retaining activities of Dihydrotestosterone.
DiltiazemThe serum concentration of Diltiazem can be decreased when it is combined with Aldosterone.
DiltiazemThe serum concentration of Aldosterone can be increased when it is combined with Diltiazem.
DipyridamoleThe serum concentration of Dipyridamole can be decreased when it is combined with Aldosterone.
DipyridamoleThe serum concentration of Aldosterone can be increased when it is combined with Dipyridamole.
DocetaxelThe serum concentration of Docetaxel can be decreased when it is combined with Aldosterone.
DomperidoneThe serum concentration of Domperidone can be decreased when it is combined with Aldosterone.
DonepezilThe risk or severity of adverse effects can be increased when Aldosterone is combined with Donepezil.
DoxazosinThe serum concentration of Aldosterone can be increased when it is combined with Doxazosin.
DoxepinThe serum concentration of Aldosterone can be increased when it is combined with Doxepin.
DoxorubicinThe serum concentration of Doxorubicin can be decreased when it is combined with Aldosterone.
DronabinolThe serum concentration of Aldosterone can be increased when it is combined with Dronabinol.
DronedaroneThe serum concentration of Aldosterone can be increased when it is combined with Dronedarone.
EchothiophateThe risk or severity of adverse effects can be increased when Aldosterone is combined with Echothiophate.
EdoxabanThe serum concentration of Edoxaban can be decreased when it is combined with Aldosterone.
EdrophoniumThe risk or severity of adverse effects can be increased when Aldosterone is combined with Edrophonium.
ElbasvirThe serum concentration of Aldosterone can be increased when it is combined with Elbasvir.
EletriptanThe serum concentration of Eletriptan can be decreased when it is combined with Aldosterone.
EnalaprilThe serum concentration of Aldosterone can be increased when it is combined with Enalapril.
EnzalutamideThe serum concentration of Aldosterone can be increased when it is combined with Enzalutamide.
EpinastineThe serum concentration of Epinastine can be decreased when it is combined with Aldosterone.
ErgonovineThe serum concentration of Aldosterone can be increased when it is combined with Ergonovine.
ErgotamineThe serum concentration of Aldosterone can be increased when it is combined with Ergotamine.
ErlotinibThe serum concentration of Erlotinib can be decreased when it is combined with Aldosterone.
ErythromycinThe serum concentration of Erythromycin can be decreased when it is combined with Aldosterone.
EstradiolThe serum concentration of Aldosterone can be increased when it is combined with Estradiol.
EstradiolThe serum concentration of Estradiol can be decreased when it is combined with Aldosterone.
EstramustineThe serum concentration of Aldosterone can be increased when it is combined with Estramustine.
EstriolThe serum concentration of Aldosterone can be increased when it is combined with Estriol.
EstriolThe serum concentration of Estriol can be decreased when it is combined with Aldosterone.
EstroneThe serum concentration of Aldosterone can be increased when it is combined with Estrone.
EstroneThe serum concentration of Estrone can be decreased when it is combined with Aldosterone.
Etacrynic acidAldosterone may increase the hypokalemic activities of Etacrynic acid.
Ethinyl EstradiolThe serum concentration of Aldosterone can be increased when it is combined with Ethinyl Estradiol.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Aldosterone.
EtoposideThe serum concentration of Etoposide can be decreased when it is combined with Aldosterone.
EtoposideThe serum concentration of Aldosterone can be increased when it is combined with Etoposide.
EtravirineThe serum concentration of Aldosterone can be increased when it is combined with Etravirine.
EzetimibeThe serum concentration of Ezetimibe can be decreased when it is combined with Aldosterone.
FelodipineThe serum concentration of Aldosterone can be increased when it is combined with Felodipine.
FentanylThe serum concentration of Aldosterone can be increased when it is combined with Fentanyl.
FenthionThe risk or severity of adverse effects can be increased when Aldosterone is combined with Fenthion.
FesoterodineThe serum concentration of Fesoterodine can be decreased when it is combined with Aldosterone.
FexofenadineThe serum concentration of Fexofenadine can be decreased when it is combined with Aldosterone.
FexofenadineThe serum concentration of Aldosterone can be increased when it is combined with Fexofenadine.
FidaxomicinThe serum concentration of Fidaxomicin can be decreased when it is combined with Aldosterone.
FidaxomicinThe serum concentration of Aldosterone can be increased when it is combined with Fidaxomicin.
FluconazoleThe serum concentration of Aldosterone can be increased when it is combined with Fluconazole.
FluoxetineThe serum concentration of Aldosterone can be increased when it is combined with Fluoxetine.
FluoxymesteroneAldosterone may increase the fluid retaining activities of Fluoxymesterone.
FlupentixolThe serum concentration of Aldosterone can be increased when it is combined with Flupentixol.
FluphenazineThe serum concentration of Aldosterone can be increased when it is combined with Fluphenazine.
FlurazepamThe serum concentration of Aldosterone can be increased when it is combined with Flurazepam.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be decreased when it is combined with Aldosterone.
FluvoxamineThe serum concentration of Aldosterone can be increased when it is combined with Fluvoxamine.
FosaprepitantThe serum concentration of Aldosterone can be increased when it is combined with Fosaprepitant.
FosphenytoinThe serum concentration of Aldosterone can be decreased when it is combined with Fosphenytoin.
FurosemideAldosterone may increase the hypokalemic activities of Furosemide.
GalantamineThe risk or severity of adverse effects can be increased when Aldosterone is combined with Galantamine.
Gallamine TriethiodideThe risk or severity of adverse effects can be increased when Aldosterone is combined with Gallamine Triethiodide.
GefitinibThe serum concentration of Gefitinib can be decreased when it is combined with Aldosterone.
GefitinibThe serum concentration of Aldosterone can be increased when it is combined with Gefitinib.
GemcitabineThe serum concentration of Gemcitabine can be decreased when it is combined with Aldosterone.
GenisteinThe serum concentration of Aldosterone can be increased when it is combined with Genistein.
Ginkgo bilobaThe risk or severity of adverse effects can be increased when Aldosterone is combined with Ginkgo biloba.
GlyburideThe serum concentration of Aldosterone can be increased when it is combined with Glyburide.
GlycerolThe serum concentration of Aldosterone can be increased when it is combined with Glycerol.
Glycerol PhenylbutyrateThe therapeutic efficacy of Glycerol Phenylbutyrate can be decreased when used in combination with Aldosterone.
Gramicidin DThe serum concentration of Aldosterone can be increased when it is combined with Gramicidin D.
GrazoprevirThe serum concentration of Grazoprevir can be decreased when it is combined with Aldosterone.
GrepafloxacinThe serum concentration of Grepafloxacin can be decreased when it is combined with Aldosterone.
GrepafloxacinThe serum concentration of Aldosterone can be increased when it is combined with Grepafloxacin.
HaloperidolThe serum concentration of Haloperidol can be decreased when it is combined with Aldosterone.
HaloperidolThe serum concentration of Aldosterone can be increased when it is combined with Haloperidol.
HexestrolThe serum concentration of Aldosterone can be increased when it is combined with Hexestrol.
Huperzine AThe risk or severity of adverse effects can be increased when Aldosterone is combined with Huperzine A.
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Aldosterone.
HydrochlorothiazideAldosterone may increase the hypokalemic activities of Hydrochlorothiazide.
HydrocortisoneThe serum concentration of Hydrocortisone can be decreased when it is combined with Aldosterone.
HydrocortisoneThe serum concentration of Aldosterone can be increased when it is combined with Hydrocortisone.
HydroflumethiazideAldosterone may increase the hypokalemic activities of Hydroflumethiazide.
IbuprofenThe serum concentration of Ibuprofen can be decreased when it is combined with Aldosterone.
IdelalisibThe serum concentration of Idelalisib can be decreased when it is combined with Aldosterone.
IdelalisibThe serum concentration of Aldosterone can be increased when it is combined with Idelalisib.
ImatinibThe serum concentration of Imatinib can be decreased when it is combined with Aldosterone.
ImatinibThe serum concentration of Aldosterone can be increased when it is combined with Imatinib.
ImipramineThe serum concentration of Imipramine can be decreased when it is combined with Aldosterone.
ImipramineThe serum concentration of Aldosterone can be increased when it is combined with Imipramine.
IndacaterolIndacaterol may increase the hypokalemic activities of Aldosterone.
IndacaterolThe serum concentration of Indacaterol can be decreased when it is combined with Aldosterone.
IndapamideAldosterone may increase the hypokalemic activities of Indapamide.
IndinavirThe serum concentration of Aldosterone can be decreased when it is combined with Indinavir.
IndomethacinThe serum concentration of Indomethacin can be decreased when it is combined with Aldosterone.
IndomethacinThe serum concentration of Aldosterone can be increased when it is combined with Indomethacin.
IrinotecanThe serum concentration of Irinotecan can be decreased when it is combined with Aldosterone.
IsavuconazoniumThe serum concentration of Aldosterone can be increased when it is combined with Isavuconazonium.
IsoflurophateThe risk or severity of adverse effects can be increased when Aldosterone is combined with Isoflurophate.
IsoniazidThe serum concentration of Isoniazid can be decreased when it is combined with Aldosterone.
ItraconazoleThe serum concentration of Aldosterone can be increased when it is combined with Itraconazole.
IvacaftorThe serum concentration of Aldosterone can be increased when it is combined with Ivacaftor.
IvermectinThe serum concentration of Ivermectin can be decreased when it is combined with Aldosterone.
IvermectinThe serum concentration of Aldosterone can be increased when it is combined with Ivermectin.
KetamineThe serum concentration of Aldosterone can be increased when it is combined with Ketamine.
KetazolamThe serum concentration of Ketazolam can be decreased when it is combined with Aldosterone.
KetoconazoleThe serum concentration of Ketoconazole can be decreased when it is combined with Aldosterone.
KetoconazoleThe serum concentration of Aldosterone can be increased when it is combined with Ketoconazole.
LamivudineThe serum concentration of Lamivudine can be decreased when it is combined with Aldosterone.
LamotrigineThe serum concentration of Lamotrigine can be decreased when it is combined with Aldosterone.
LansoprazoleThe serum concentration of Lansoprazole can be decreased when it is combined with Aldosterone.
LansoprazoleThe serum concentration of Aldosterone can be increased when it is combined with Lansoprazole.
LapatinibThe serum concentration of Aldosterone can be increased when it is combined with Lapatinib.
LedipasvirThe serum concentration of Ledipasvir can be decreased when it is combined with Aldosterone.
LenalidomideThe serum concentration of Lenalidomide can be decreased when it is combined with Aldosterone.
LenvatinibThe serum concentration of Lenvatinib can be decreased when it is combined with Aldosterone.
LevetiracetamThe serum concentration of Levetiracetam can be decreased when it is combined with Aldosterone.
LevofloxacinThe serum concentration of Levofloxacin can be decreased when it is combined with Aldosterone.
LevofloxacinThe serum concentration of Aldosterone can be increased when it is combined with Levofloxacin.
LevomilnacipranThe serum concentration of Levomilnacipran can be decreased when it is combined with Aldosterone.
LevothyroxineThe serum concentration of Aldosterone can be decreased when it is combined with Levothyroxine.
LidocaineThe serum concentration of Aldosterone can be increased when it is combined with Lidocaine.
LinagliptinThe serum concentration of Linagliptin can be decreased when it is combined with Aldosterone.
LiothyronineThe serum concentration of Aldosterone can be decreased when it is combined with Liothyronine.
LiotrixThe serum concentration of Aldosterone can be decreased when it is combined with Liotrix.
LisinoprilThe serum concentration of Aldosterone can be increased when it is combined with Lisinopril.
LomitapideThe serum concentration of Aldosterone can be increased when it is combined with Lomitapide.
LoperamideThe serum concentration of Loperamide can be decreased when it is combined with Aldosterone.
LoperamideThe serum concentration of Aldosterone can be increased when it is combined with Loperamide.
LopinavirThe serum concentration of Aldosterone can be increased when it is combined with Lopinavir.
LoratadineThe serum concentration of Aldosterone can be increased when it is combined with Loratadine.
LosartanThe serum concentration of Losartan can be decreased when it is combined with Aldosterone.
LosartanThe serum concentration of Aldosterone can be increased when it is combined with Losartan.
LovastatinThe serum concentration of Aldosterone can be increased when it is combined with Lovastatin.
LumacaftorThe serum concentration of Aldosterone can be decreased when it is combined with Lumacaftor.
MagaldrateThe bioavailability of Aldosterone can be decreased when combined with Magaldrate.
Magnesium carbonateThe bioavailability of Aldosterone can be decreased when combined with Magnesium carbonate.
Magnesium hydroxideThe bioavailability of Aldosterone can be decreased when combined with Magnesium hydroxide.
Magnesium oxideThe bioavailability of Aldosterone can be decreased when combined with Magnesium oxide.
Magnesium TrisilicateThe bioavailability of Aldosterone can be decreased when combined with Magnesium Trisilicate.
MalathionThe risk or severity of adverse effects can be increased when Aldosterone is combined with Malathion.
MannitolThe serum concentration of Mannitol can be decreased when it is combined with Aldosterone.
MaprotilineThe serum concentration of Aldosterone can be increased when it is combined with Maprotiline.
MebendazoleThe serum concentration of Aldosterone can be increased when it is combined with Mebendazole.
MefloquineThe serum concentration of Aldosterone can be increased when it is combined with Mefloquine.
MefloquineThe risk or severity of adverse effects can be increased when Aldosterone is combined with Mefloquine.
Megestrol acetateThe serum concentration of Aldosterone can be increased when it is combined with Megestrol acetate.
MemantineThe risk or severity of adverse effects can be increased when Aldosterone is combined with Memantine.
MeprobamateThe serum concentration of Aldosterone can be increased when it is combined with Meprobamate.
MesalazineThe risk or severity of adverse effects can be increased when Mesalazine is combined with Aldosterone.
MestranolThe serum concentration of Aldosterone can be increased when it is combined with Mestranol.
MethadoneThe serum concentration of Aldosterone can be increased when it is combined with Methadone.
MethotrexateThe serum concentration of Methotrexate can be decreased when it is combined with Aldosterone.
MethyclothiazideAldosterone may increase the hypokalemic activities of Methyclothiazide.
MethylprednisoloneThe serum concentration of Methylprednisolone can be decreased when it is combined with Aldosterone.
MethyltestosteroneAldosterone may increase the fluid retaining activities of Methyltestosterone.
MetolazoneAldosterone may increase the hypokalemic activities of Metolazone.
MetoprololThe serum concentration of Metoprolol can be decreased when it is combined with Aldosterone.
MetoprololThe serum concentration of Aldosterone can be increased when it is combined with Metoprolol.
MibefradilThe serum concentration of Aldosterone can be increased when it is combined with Mibefradil.
MiconazoleThe serum concentration of Aldosterone can be increased when it is combined with Miconazole.
MidazolamThe serum concentration of Midazolam can be decreased when it is combined with Aldosterone.
MifepristoneThe therapeutic efficacy of Aldosterone can be decreased when used in combination with Mifepristone.
MinaprineThe risk or severity of adverse effects can be increased when Aldosterone is combined with Minaprine.
MirabegronThe serum concentration of Mirabegron can be decreased when it is combined with Aldosterone.
MitomycinThe serum concentration of Aldosterone can be increased when it is combined with Mitomycin.
MitotaneThe serum concentration of Aldosterone can be decreased when it is combined with Mitotane.
MitoxantroneThe serum concentration of Mitoxantrone can be decreased when it is combined with Aldosterone.
MivacuriumMivacurium may increase the adverse neuromuscular activities of Aldosterone.
MorphineThe serum concentration of Morphine can be decreased when it is combined with Aldosterone.
MorphineThe serum concentration of Aldosterone can be increased when it is combined with Morphine.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be decreased when it is combined with Aldosterone.
NadololThe serum concentration of Nadolol can be decreased when it is combined with Aldosterone.
NaloxoneThe serum concentration of Naloxone can be decreased when it is combined with Aldosterone.
NaltrexoneThe serum concentration of Aldosterone can be increased when it is combined with Naltrexone.
NaringeninThe serum concentration of Aldosterone can be increased when it is combined with Naringenin.
NefazodoneThe serum concentration of Aldosterone can be decreased when it is combined with Nefazodone.
NelfinavirThe serum concentration of Aldosterone can be decreased when it is combined with Nelfinavir.
NeostigmineThe serum concentration of Aldosterone can be increased when it is combined with Neostigmine.
NeostigmineThe risk or severity of adverse effects can be increased when Aldosterone is combined with Neostigmine.
NevirapineThe serum concentration of Aldosterone can be decreased when it is combined with Nevirapine.
NicardipineThe serum concentration of Nicardipine can be decreased when it is combined with Aldosterone.
NicardipineThe serum concentration of Aldosterone can be increased when it is combined with Nicardipine.
NicorandilThe risk or severity of adverse effects can be increased when Aldosterone is combined with Nicorandil.
NifedipineThe serum concentration of Aldosterone can be decreased when it is combined with Nifedipine.
NilotinibThe serum concentration of Nilotinib can be decreased when it is combined with Aldosterone.
NilotinibThe serum concentration of Aldosterone can be increased when it is combined with Nilotinib.
NintedanibThe serum concentration of Nintedanib can be decreased when it is combined with Aldosterone.
NisoldipineThe serum concentration of Aldosterone can be increased when it is combined with Nisoldipine.
NitrazepamThe serum concentration of Aldosterone can be increased when it is combined with Nitrazepam.
NitrendipineThe serum concentration of Aldosterone can be increased when it is combined with Nitrendipine.
NizatidineThe serum concentration of Nizatidine can be decreased when it is combined with Aldosterone.
NorethisteroneThe serum concentration of Aldosterone can be decreased when it is combined with Norethisterone.
OlanzapineThe serum concentration of Olanzapine can be decreased when it is combined with Aldosterone.
OmbitasvirThe serum concentration of Ombitasvir can be decreased when it is combined with Aldosterone.
OmeprazoleThe serum concentration of Aldosterone can be increased when it is combined with Omeprazole.
OsimertinibThe serum concentration of Osimertinib can be decreased when it is combined with Aldosterone.
OxandroloneAldosterone may increase the fluid retaining activities of Oxandrolone.
OxymetholoneAldosterone may increase the fluid retaining activities of Oxymetholone.
P-NitrophenolThe serum concentration of Aldosterone can be increased when it is combined with P-Nitrophenol.
PaclitaxelThe serum concentration of Paclitaxel can be decreased when it is combined with Aldosterone.
PaclitaxelThe serum concentration of Aldosterone can be increased when it is combined with Paclitaxel.
Palmitic AcidThe serum concentration of Aldosterone can be increased when it is combined with Palmitic Acid.
PanobinostatThe serum concentration of Panobinostat can be decreased when it is combined with Aldosterone.
PantoprazoleThe serum concentration of Aldosterone can be increased when it is combined with Pantoprazole.
ParoxetineThe serum concentration of Aldosterone can be increased when it is combined with Paroxetine.
PazopanibThe serum concentration of Pazopanib can be decreased when it is combined with Aldosterone.
PentobarbitalThe serum concentration of Aldosterone can be decreased when it is combined with Pentobarbital.
PerindoprilThe serum concentration of Aldosterone can be increased when it is combined with Perindopril.
PhenobarbitalThe serum concentration of Phenobarbital can be decreased when it is combined with Aldosterone.
Phenylacetic acidThe therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Aldosterone.
PhenytoinThe serum concentration of Phenytoin can be decreased when it is combined with Aldosterone.
PhysostigmineThe risk or severity of adverse effects can be increased when Aldosterone is combined with Physostigmine.
PimozideThe serum concentration of Aldosterone can be increased when it is combined with Pimozide.
PiretanideAldosterone may increase the hypokalemic activities of Piretanide.
PitavastatinThe serum concentration of Pitavastatin can be decreased when it is combined with Aldosterone.
Platelet Activating FactorThe serum concentration of Aldosterone can be decreased when it is combined with Platelet Activating Factor.
Polyestradiol phosphateThe serum concentration of Aldosterone can be increased when it is combined with Polyestradiol phosphate.
PolythiazideAldosterone may increase the hypokalemic activities of Polythiazide.
PomalidomideThe serum concentration of Pomalidomide can be decreased when it is combined with Aldosterone.
PonatinibThe serum concentration of Ponatinib can be decreased when it is combined with Aldosterone.
PonatinibThe serum concentration of Aldosterone can be increased when it is combined with Ponatinib.
PosaconazoleThe serum concentration of Aldosterone can be increased when it is combined with Posaconazole.
PravastatinThe serum concentration of Pravastatin can be decreased when it is combined with Aldosterone.
PravastatinThe serum concentration of Aldosterone can be increased when it is combined with Pravastatin.
PrazosinThe serum concentration of Prazosin can be decreased when it is combined with Aldosterone.
PrazosinThe serum concentration of Aldosterone can be increased when it is combined with Prazosin.
PrednisoloneThe serum concentration of Prednisolone can be decreased when it is combined with Aldosterone.
PrednisoneThe serum concentration of Prednisone can be decreased when it is combined with Aldosterone.
PrednisoneThe serum concentration of Aldosterone can be increased when it is combined with Prednisone.
PrimidoneThe serum concentration of Aldosterone can be decreased when it is combined with Primidone.
ProbenecidThe serum concentration of Aldosterone can be increased when it is combined with Probenecid.
ProgesteroneThe serum concentration of Aldosterone can be decreased when it is combined with Progesterone.
PromethazineThe serum concentration of Aldosterone can be increased when it is combined with Promethazine.
PropafenoneThe serum concentration of Aldosterone can be increased when it is combined with Propafenone.
PropranololThe serum concentration of Propranolol can be decreased when it is combined with Aldosterone.
PropranololThe serum concentration of Aldosterone can be increased when it is combined with Propranolol.
ProtriptylineThe serum concentration of Aldosterone can be increased when it is combined with Protriptyline.
PyridostigmineThe risk or severity of adverse effects can be increased when Aldosterone is combined with Pyridostigmine.
QuercetinThe serum concentration of Aldosterone can be increased when it is combined with Quercetin.
QuetiapineThe serum concentration of Quetiapine can be decreased when it is combined with Aldosterone.
QuinacrineThe serum concentration of Aldosterone can be increased when it is combined with Quinacrine.
QuinestrolThe serum concentration of Aldosterone can be increased when it is combined with Quinestrol.
QuinethazoneAldosterone may increase the hypokalemic activities of Quinethazone.
QuinidineThe serum concentration of Quinidine can be decreased when it is combined with Aldosterone.
QuinidineThe serum concentration of Aldosterone can be increased when it is combined with Quinidine.
QuinineThe serum concentration of Quinine can be decreased when it is combined with Aldosterone.
QuinineThe serum concentration of Aldosterone can be increased when it is combined with Quinine.
Rabies vaccineThe risk or severity of adverse effects can be increased when Aldosterone is combined with Rabies vaccine.
RanitidineThe serum concentration of Ranitidine can be decreased when it is combined with Aldosterone.
RanitidineThe serum concentration of Aldosterone can be increased when it is combined with Ranitidine.
RanolazineThe serum concentration of Aldosterone can be increased when it is combined with Ranolazine.
RapacuroniumRapacuronium may increase the adverse neuromuscular activities of Aldosterone.
ReboxetineThe serum concentration of Aldosterone can be increased when it is combined with Reboxetine.
RegorafenibThe serum concentration of Aldosterone can be increased when it is combined with Regorafenib.
ReserpineThe serum concentration of Aldosterone can be decreased when it is combined with Reserpine.
RifabutinThe serum concentration of Aldosterone can be decreased when it is combined with Rifabutin.
RifampicinThe serum concentration of Aldosterone can be decreased when it is combined with Rifampicin.
RifapentineThe serum concentration of Aldosterone can be decreased when it is combined with Rifapentine.
RilpivirineThe serum concentration of Aldosterone can be increased when it is combined with Rilpivirine.
RisperidoneThe serum concentration of Risperidone can be decreased when it is combined with Aldosterone.
RitonavirThe serum concentration of Aldosterone can be decreased when it is combined with Ritonavir.
RivaroxabanThe serum concentration of Rivaroxaban can be decreased when it is combined with Aldosterone.
RivastigmineThe risk or severity of adverse effects can be increased when Aldosterone is combined with Rivastigmine.
RolapitantThe serum concentration of Aldosterone can be increased when it is combined with Rolapitant.
RomidepsinThe serum concentration of Romidepsin can be decreased when it is combined with Aldosterone.
Salicylic acidThe risk or severity of adverse effects can be increased when Salicylic acid is combined with Aldosterone.
Salicylic acidThe serum concentration of Salicylic acid can be decreased when it is combined with Aldosterone.
SaquinavirThe serum concentration of Aldosterone can be decreased when it is combined with Saquinavir.
ScopolamineThe serum concentration of Aldosterone can be increased when it is combined with Scopolamine.
SelegilineThe serum concentration of Aldosterone can be increased when it is combined with Selegiline.
SelexipagThe serum concentration of Selexipag can be decreased when it is combined with Aldosterone.
SertralineThe serum concentration of Aldosterone can be increased when it is combined with Sertraline.
SilodosinThe serum concentration of Silodosin can be decreased when it is combined with Aldosterone.
SimeprevirThe serum concentration of Simeprevir can be decreased when it is combined with Aldosterone.
SimeprevirThe serum concentration of Aldosterone can be increased when it is combined with Simeprevir.
SimvastatinThe serum concentration of Aldosterone can be increased when it is combined with Simvastatin.
SirolimusThe serum concentration of Aldosterone can be decreased when it is combined with Sirolimus.
SitagliptinThe serum concentration of Sitagliptin can be decreased when it is combined with Aldosterone.
Sodium phenylbutyrateThe therapeutic efficacy of Sodium phenylbutyrate can be decreased when used in combination with Aldosterone.
SofosbuvirThe serum concentration of Sofosbuvir can be decreased when it is combined with Aldosterone.
SorafenibThe serum concentration of Sorafenib can be decreased when it is combined with Aldosterone.
SorafenibThe serum concentration of Aldosterone can be increased when it is combined with Sorafenib.
SparfloxacinThe serum concentration of Sparfloxacin can be decreased when it is combined with Aldosterone.
SphingosineThe serum concentration of Sphingosine can be decreased when it is combined with Aldosterone.
SpironolactoneThe serum concentration of Aldosterone can be increased when it is combined with Spironolactone.
St. John's WortThe serum concentration of Aldosterone can be decreased when it is combined with St. John's Wort.
StanozololAldosterone may increase the fluid retaining activities of Stanozolol.
StaurosporineThe serum concentration of Aldosterone can be increased when it is combined with Staurosporine.
StreptozocinThe serum concentration of Aldosterone can be decreased when it is combined with Streptozocin.
SulfinpyrazoneThe serum concentration of Aldosterone can be increased when it is combined with Sulfinpyrazone.
SumatriptanThe serum concentration of Aldosterone can be increased when it is combined with Sumatriptan.
SunitinibThe serum concentration of Aldosterone can be increased when it is combined with Sunitinib.
Synthetic Conjugated Estrogens, AThe serum concentration of Aldosterone can be increased when it is combined with Synthetic Conjugated Estrogens, A.
Synthetic Conjugated Estrogens, BThe serum concentration of Aldosterone can be increased when it is combined with Synthetic Conjugated Estrogens, B.
TacrineThe serum concentration of Aldosterone can be increased when it is combined with Tacrine.
TacrineThe risk or severity of adverse effects can be increased when Aldosterone is combined with Tacrine.
TacrolimusThe serum concentration of Tacrolimus can be decreased when it is combined with Aldosterone.
TamoxifenThe serum concentration of Tamoxifen can be decreased when it is combined with Aldosterone.
Taurocholic AcidThe serum concentration of Taurocholic Acid can be decreased when it is combined with Aldosterone.
Taurocholic AcidThe serum concentration of Aldosterone can be increased when it is combined with Taurocholic Acid.
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Aldosterone.
TelaprevirThe serum concentration of Telaprevir can be decreased when it is combined with Aldosterone.
TelaprevirThe serum concentration of Aldosterone can be increased when it is combined with Telaprevir.
TelithromycinThe serum concentration of Aldosterone can be increased when it is combined with Telithromycin.
TelmisartanThe serum concentration of Aldosterone can be increased when it is combined with Telmisartan.
TemsirolimusThe serum concentration of Temsirolimus can be decreased when it is combined with Aldosterone.
TemsirolimusThe serum concentration of Aldosterone can be increased when it is combined with Temsirolimus.
TerazosinThe serum concentration of Aldosterone can be increased when it is combined with Terazosin.
TerfenadineThe serum concentration of Aldosterone can be increased when it is combined with Terfenadine.
TesmilifeneThe serum concentration of Aldosterone can be decreased when it is combined with Tesmilifene.
TestosteroneAldosterone may increase the fluid retaining activities of Testosterone.
TestosteroneThe serum concentration of Aldosterone can be increased when it is combined with Testosterone.
TiboloneThe serum concentration of Aldosterone can be increased when it is combined with Tibolone.
TicagrelorThe serum concentration of Ticagrelor can be decreased when it is combined with Aldosterone.
TicagrelorThe serum concentration of Aldosterone can be increased when it is combined with Ticagrelor.
TimololThe serum concentration of Timolol can be decreased when it is combined with Aldosterone.
TolvaptanThe serum concentration of Tolvaptan can be decreased when it is combined with Aldosterone.
TolvaptanThe serum concentration of Aldosterone can be increased when it is combined with Tolvaptan.
TopotecanThe serum concentration of Topotecan can be decreased when it is combined with Aldosterone.
TorasemideAldosterone may increase the hypokalemic activities of Torasemide.
ToremifeneThe serum concentration of Toremifene can be decreased when it is combined with Aldosterone.
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be decreased when it is combined with Aldosterone.
TrazodoneThe serum concentration of Aldosterone can be decreased when it is combined with Trazodone.
TrichlorfonThe risk or severity of adverse effects can be increased when Aldosterone is combined with Trichlorfon.
TrichlormethiazideAldosterone may increase the hypokalemic activities of Trichlormethiazide.
TrifluoperazineThe serum concentration of Aldosterone can be increased when it is combined with Trifluoperazine.
TriflupromazineThe serum concentration of Aldosterone can be increased when it is combined with Triflupromazine.
TrimethoprimThe serum concentration of Aldosterone can be decreased when it is combined with Trimethoprim.
TrimipramineThe serum concentration of Aldosterone can be increased when it is combined with Trimipramine.
TroleandomycinThe serum concentration of Aldosterone can be increased when it is combined with Troleandomycin.
TubocurarineThe risk or severity of adverse effects can be increased when Aldosterone is combined with Tubocurarine.
UlipristalThe serum concentration of Ulipristal can be decreased when it is combined with Aldosterone.
UmeclidiniumThe serum concentration of Umeclidinium can be decreased when it is combined with Aldosterone.
VecuroniumThe serum concentration of Vecuronium can be decreased when it is combined with Aldosterone.
VenlafaxineThe serum concentration of Venlafaxine can be decreased when it is combined with Aldosterone.
VenlafaxineThe serum concentration of Aldosterone can be increased when it is combined with Venlafaxine.
VerapamilThe serum concentration of Aldosterone can be decreased when it is combined with Verapamil.
VinblastineThe serum concentration of Vinblastine can be decreased when it is combined with Aldosterone.
VincristineThe serum concentration of Vincristine can be decreased when it is combined with Aldosterone.
VinorelbineThe serum concentration of Aldosterone can be increased when it is combined with Vinorelbine.
VismodegibThe serum concentration of Vismodegib can be decreased when it is combined with Aldosterone.
VoriconazoleThe serum concentration of Aldosterone can be increased when it is combined with Voriconazole.
WarfarinAldosterone may increase the anticoagulant activities of Warfarin.
ZeranolThe serum concentration of Aldosterone can be increased when it is combined with Zeranol.
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Aldosterone.
ZimelidineThe serum concentration of Aldosterone can be increased when it is combined with Zimelidine.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Zinc ion binding
Specific Function:
Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.
Gene Name:
NR3C2
Uniprot ID:
P08235
Molecular Weight:
107066.575 Da
References
  1. Bruner KL, Derfoul A, Robertson NM, Guerriero G, Fernandes-Alnemri T, Alnemri ES, Litwack G: The unliganded mineralocorticoid receptor is associated with heat shock proteins 70 and 90 and the immunophilin FKBP-52. Recept Signal Transduct. 1997;7(2):85-98. [PubMed:9392437 ]
  2. Bunda S, Liu P, Wang Y, Liu K, Hinek A: Aldosterone induces elastin production in cardiac fibroblasts through activation of insulin-like growth factor-I receptors in a mineralocorticoid receptor-independent manner. Am J Pathol. 2007 Sep;171(3):809-19. [PubMed:17724138 ]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid 11-beta-monooxygenase activity
Specific Function:
Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.
Gene Name:
CYP11B1
Uniprot ID:
P15538
Molecular Weight:
57572.44 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid 11-beta-monooxygenase activity
Specific Function:
Preferentially catalyzes the conversion of 11-deoxycorticosterone to aldosterone via corticosterone and 18-hydroxycorticosterone.
Gene Name:
CYP11B2
Uniprot ID:
P19099
Molecular Weight:
57559.62 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Steroid 17-alpha-monooxygenase activity
Specific Function:
Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.
Gene Name:
CYP17A1
Uniprot ID:
P05093
Molecular Weight:
57369.995 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinducer
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Romiti N, Tramonti G, Chieli E: Influence of different chemicals on MDR-1 P-glycoprotein expression and activity in the HK-2 proximal tubular cell line. Toxicol Appl Pharmacol. 2002 Sep 1;183(2):83-91. [PubMed:12387747 ]
  2. Ueda K, Okamura N, Hirai M, Tanigawara Y, Saeki T, Kioka N, Komano T, Hori R: Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone. J Biol Chem. 1992 Dec 5;267(34):24248-52. [PubMed:1360010 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Symporter activity
Specific Function:
Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3.
Gene Name:
SLC22A5
Uniprot ID:
O76082
Molecular Weight:
62751.08 Da
References
  1. Ohashi R, Tamai I, Yabuuchi H, Nezu JI, Oku A, Sai Y, Shimane M, Tsuji A: Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther. 1999 Nov;291(2):778-84. [PubMed:10525100 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.
Gene Name:
SLCO1A2
Uniprot ID:
P46721
Molecular Weight:
74144.105 Da
References
  1. Kanai N, Lu R, Bao Y, Wolkoff AW, Schuster VL: Transient expression of oatp organic anion transporter in mammalian cells: identification of candidate substrates. Am J Physiol. 1996 Feb;270(2 Pt 2):F319-25. [PubMed:8779893 ]
  2. Bossuyt X, Muller M, Hagenbuch B, Meier PJ: Polyspecific drug and steroid clearance by an organic anion transporter of mammalian liver. J Pharmacol Exp Ther. 1996 Mar;276(3):891-6. [PubMed:8786566 ]
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Drug created on September 11, 2007 11:49 / Updated on August 17, 2016 12:24