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Identification
NameDronedarone
Accession NumberDB04855
TypeSmall Molecule
GroupsApproved
DescriptionDronedarone is a sinus rhythm controller for management of paroxysmal or persistent atrial fibrillation. Classified as a Class III antiarrhythmic but displays properties of all four Vaughan-Williams classes, dronedarone blocks a multitude of channels (sodium, potassium, calcium), and demonstrates antiadrenergic properties. Chemically, it is a benzofuran derivative. FDA approved on July 1, 2009.
Structure
Thumb
Synonyms
Multaq
N-(2-Butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)-5-benzofuranyl)-methanesulfonamide
N-(2-Butyl-3-(P-(3-(dibutylamino)propoxy)benzoyl)-5-benzofuranyl)methanesulfonamide
SR 33589
SR 33589b
External Identifiers
  • SR33589
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
MultaqFilm-coated tablet400 mgOral useSanofi Aventis Groupe2009-11-26Not applicableEu
Multaqtablet, film coated400 mg/1oralSanofi Aventis U.S. Llc2009-07-01Not applicableUs
Multaqtablet400 mgoralSanofi Aventis Canada Inc2009-09-28Not applicableCanada
MultaqFilm-coated tablet400 mgOral useSanofi Aventis Groupe2009-11-26Not applicableEu
Multaqtablet, film coated400 mg/1oralSanofi Winthrop Industries2009-07-01Not applicableUs
MultaqFilm-coated tablet400 mgOral useSanofi Aventis Groupe2009-11-26Not applicableEu
Multaqtablet, film coated400 mg/1oralPhysicians Total Care, Inc.2010-02-23Not applicableUs
MultaqFilm-coated tablet400 mgOral useSanofi Aventis Groupe2009-11-26Not applicableEu
Multaqtablet, film coated400 mg/1oralCardinal Health2009-07-01Not applicableUs
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Dronedarone Hydrochloride
Thumb
  • InChI Key: DWKVCQXJYURSIQ-UHFFFAOYSA-N
  • Monoisotopic Mass: 592.273770957
  • Average Mass: 593.217
DBSALT000061
Categories
UNIIJQZ1L091Y2
CAS number141626-36-0
WeightAverage: 556.756
Monoisotopic: 556.297093218
Chemical FormulaC31H44N2O5S
InChI KeyInChIKey=ZQTNQVWKHCQYLQ-UHFFFAOYSA-N
InChI
InChI=1S/C31H44N2O5S/c1-5-8-12-29-30(27-23-25(32-39(4,35)36)15-18-28(27)38-29)31(34)24-13-16-26(17-14-24)37-22-11-21-33(19-9-6-2)20-10-7-3/h13-18,23,32H,5-12,19-22H2,1-4H3
IUPAC Name
N-(2-butyl-3-{4-[3-(dibutylamino)propoxy]benzoyl}-1-benzofuran-5-yl)methanesulfonamide
SMILES
CCCCN(CCCC)CCCOC1=CC=C(C=C1)C(=O)C1=C(CCCC)OC2=C1C=C(NS(C)(=O)=O)C=C2
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as sulfanilides. These are organic aromatic compounds containing a sulfanilide moiety, with the general structure RS(=O)(=O)NC1=CC=CC=C1.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassSulfanilides
Direct ParentSulfanilides
Alternative Parents
Substituents
  • Sulfanilide
  • Benzofuran
  • Acetophenone
  • Aryl ketone
  • 3-aroylfuran
  • Phenol ether
  • Benzoyl
  • Alkyl aryl ether
  • Heteroaromatic compound
  • Aminosulfonyl compound
  • Sulfonyl
  • Sulfonic acid derivative
  • Sulfonamide
  • Furan
  • Tertiary aliphatic amine
  • Tertiary amine
  • Ketone
  • Oxacycle
  • Organoheterocyclic compound
  • Ether
  • Hydrocarbon derivative
  • Organosulfur compound
  • Organooxygen compound
  • Organonitrogen compound
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationManagement of paroxysmal or persistent atrial fibrillation via restoration of normal sinus rhythm.
PharmacodynamicsDronedarone is a non-iodinated benzofuran derivative for the management of paroxysmal or persistent atrial fibrillation. Dronedarone inhibits human atrial sodium currents (INa) in a dose dependent manner in which a concentration of 0.3 μM is sufficient to completely inhibit INa. Chemically it is related to amiodarone, a popular antiarrhythmic the use of which is limited to toxicity due its high iodine content (pulmonary fibrosis, thyroid disease) as well as by liver disease. Dronedarone lacks the iodine, and is expected to have less toxicity, yet it displays amiodarone-like class III antiarrhytmic activity in vitro and in clinical trials. Despite this advantage over amiodarone, clinical trials of dronedarone have shown that it may increase risk of stroke and mortality from cardiovascular causes and arrhythmia. Furthermore, amiodarone more potently effects action potential and refractory periods than dronedarone.
Mechanism of actionThe antiarrhythmic effect of dronedarone may be due to at least two major actions. It prolongs the duration of action potential and refractory period in myocardial tissue via inhibition of sodium and potassium channels. Via inhibition of calcium channels and blockage of beta1-adrenergic receptors, a decrease in AV conduction and sinus node function can be observed. Dronedarone can also cause an increase in blood pressure by inhibition of alpha1-adrenergic receptors.
Related Articles
AbsorptionBecause of presystemic first pass metabolism the absolute bioavailability of dronedarone without food is low, about 4%. It increases to approximately 15% when dronedarone is administered with a high fat meal. After oral administration in fed conditions, peak plasma concentrations of dronedarone and the main circulating active metabolite (N-debutyl metabolite) are reached within 3 to 6 hours. After repeated administration of 400 mg twice daily, steady state is reached within 4 to 8 days of treatment. The steady state Cmax and exposure of the main N-debutyl metabolite is similar to that of the parent compound.
Volume of distribution

When intravenously administered, the volume of distribution is 1400 L.

Protein bindingDronedarone and its N-debutyl metabolite is >98% protein bound - mainly to albumin.
Metabolism

Majority of dronedarone is eliminated by first-pass metabolism in the liver by CYP3A4 enzymes (>84%). Dronedarone is also metabolized by CYP2D6 to a lesser extent. N-DBD is its active metabolite (1/10 to 1/3 potency of dronedarone) which can penetrate the blood-brain barrier, placenta, and is excreted in breast milk. However, it does not significantly accumulate in plasma or tissue.

Route of elimination6% of the dose was excreted in the urine, mainly as metabolites (no unchanged compound excreted in urine), and 84% was excreted in feces, mainly as metabolites.
Half lifeElimination half-life: 13-19 hours
Clearance

Plasma clearance = 130-150 L/h.

ToxicityMost common adverse reactions (≥2%) are diarrhea, nausea, abdominal pain, vomiting, and asthenia.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier+0.9156
Caco-2 permeable-0.6057
P-glycoprotein substrateSubstrate0.6265
P-glycoprotein inhibitor IInhibitor0.7879
P-glycoprotein inhibitor IINon-inhibitor0.5218
Renal organic cation transporterNon-inhibitor0.7334
CYP450 2C9 substrateNon-substrate0.7339
CYP450 2D6 substrateNon-substrate0.7682
CYP450 3A4 substrateSubstrate0.6963
CYP450 1A2 substrateNon-inhibitor0.5487
CYP450 2C9 inhibitorInhibitor0.6209
CYP450 2D6 inhibitorNon-inhibitor0.8299
CYP450 2C19 inhibitorNon-inhibitor0.5319
CYP450 3A4 inhibitorNon-inhibitor0.5198
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.8288
Ames testNon AMES toxic0.5248
CarcinogenicityNon-carcinogens0.6132
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.6273 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Strong inhibitor0.8036
hERG inhibition (predictor II)Inhibitor0.8051
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
Film-coated tabletOral use400 mg
Tabletoral400 mg
Tablet, film coatedoral400 mg/1
PricesNot Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2047773 No2000-09-122011-07-24Canada
CA2294812 No2009-09-292018-06-19Canada
US5223510 No1996-07-262016-07-26Us
US7323493 No1998-06-192018-06-19Us
US8318800 No1998-06-192018-06-19Us
US8410167 No2009-04-162029-04-16Us
US8602215 No2011-06-302031-06-30Us
US9107900 No2009-04-162029-04-16Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
water solubilityInsoluble FDA label
logP7.346MSDS
Predicted Properties
PropertyValueSource
Water Solubility0.00201 mg/mLALOGPS
logP6.46ALOGPS
logP5.28ChemAxon
logS-5.4ALOGPS
pKa (Strongest Acidic)9.08ChemAxon
pKa (Strongest Basic)9.79ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area88.85 Å2ChemAxon
Rotatable Bond Count17ChemAxon
Refractivity158.13 m3·mol-1ChemAxon
Polarizability66.05 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

Arie Gutman, Gennadi Nisnevich, Lev Yudovitch, “Process for the preparation of dronedarone.” U.S. Patent US20050049302, issued March 03, 2005.

US20050049302
General References
  1. Dale KM, White CM: Dronedarone: an amiodarone analog for the treatment of atrial fibrillation and atrial flutter. Ann Pharmacother. 2007 Apr;41(4):599-605. Epub 2007 Mar 27. [PubMed:17389667 ]
  2. Iwamoto T, Watanabe Y, Kita S, Blaustein MP: Na+/Ca2+ exchange inhibitors: a new class of calcium regulators. Cardiovasc Hematol Disord Drug Targets. 2007 Sep;7(3):188-98. [PubMed:17896959 ]
  3. Celestino D, Medei E, Moro S, Elizari MV, Sicouri S: Acute in vitro effects of dronedarone, an iodine-free derivative, and amiodarone, on the rabbit sinoatrial node automaticity: a comparative study. J Cardiovasc Pharmacol Ther. 2007 Sep;12(3):248-57. [PubMed:17875953 ]
  4. Pamukcu B, Lip GY: Dronedarone as a new treatment option for atrial fibrillation patients: pharmacokinetics, pharmacodynamics and clinical practice. Expert Opin Pharmacother. 2011 Jan;12(1):131-40. doi: 10.1517/14656566.2011.540800. Epub 2010 Dec 2. [PubMed:21126199 ]
  5. De Ferrari GM, Dusi V: Drug safety evaluation of dronedarone in atrial fibrillation. Expert Opin Drug Saf. 2012 Nov;11(6):1023-45. doi: 10.1517/14740338.2012.722994. Epub 2012 Sep 13. [PubMed:22971242 ]
External Links
ATC CodesC01BD07
AHFS Codes
  • 24:04.04.20
PDB EntriesNot Available
FDA labelDownload (606 KB)
MSDSDownload (115 KB)
Interactions
Drug Interactions
Drug
4-MethoxyamphetamineThe metabolism of 4-Methoxyamphetamine can be decreased when combined with Dronedarone.
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Dronedarone.
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Dronedarone.
AcebutololAcebutolol may increase the bradycardic activities of Dronedarone.
AcenocoumarolThe serum concentration of Acenocoumarol can be increased when it is combined with Dronedarone.
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Dronedarone.
AcetylcholineThe metabolism of Acetylcholine can be decreased when combined with Dronedarone.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Dronedarone.
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Dronedarone.
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Dronedarone.
AjmalineThe metabolism of Ajmaline can be decreased when combined with Dronedarone.
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Dronedarone.
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Dronedarone.
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Dronedarone.
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Dronedarone.
AlfuzosinThe metabolism of Alfuzosin can be decreased when combined with Dronedarone.
AlfuzosinAlfuzosin may increase the QTc-prolonging activities of Dronedarone.
AliskirenThe metabolism of Aliskiren can be decreased when combined with Dronedarone.
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Dronedarone.
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Dronedarone.
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Dronedarone.
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Dronedarone.
AlosetronThe metabolism of Alosetron can be decreased when combined with Dronedarone.
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Dronedarone.
AlprenololThe metabolism of Alprenolol can be decreased when combined with Dronedarone.
AmantadineAmantadine may increase the QTc-prolonging activities of Dronedarone.
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Dronedarone.
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Dronedarone.
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Dronedarone.
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Dronedarone.
AmiodaroneThe serum concentration of Dronedarone can be increased when it is combined with Amiodarone.
AmiodaroneDronedarone may increase the QTc-prolonging activities of Amiodarone.
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Dronedarone.
AmitriptylineAmitriptyline may increase the QTc-prolonging activities of Dronedarone.
AmlodipineThe metabolism of Amlodipine can be decreased when combined with Dronedarone.
AmoxapineAmoxapine may increase the QTc-prolonging activities of Dronedarone.
AmoxapineThe metabolism of Amoxapine can be decreased when combined with Dronedarone.
AmphetamineThe metabolism of Amphetamine can be decreased when combined with Dronedarone.
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Dronedarone.
AmsacrineThe metabolism of Amsacrine can be decreased when combined with Dronedarone.
AnagrelideAnagrelide may increase the QTc-prolonging activities of Dronedarone.
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Dronedarone.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Dronedarone.
ApomorphineApomorphine may increase the QTc-prolonging activities of Dronedarone.
ApremilastThe metabolism of Apremilast can be decreased when combined with Dronedarone.
AprepitantThe serum concentration of Dronedarone can be increased when it is combined with Aprepitant.
AprepitantThe metabolism of Aprepitant can be decreased when combined with Dronedarone.
AprindineThe metabolism of Aprindine can be decreased when combined with Dronedarone.
ArformoterolArformoterol may increase the QTc-prolonging activities of Dronedarone.
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Dronedarone.
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Dronedarone.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Dronedarone.
AripiprazoleAripiprazole may increase the QTc-prolonging activities of Dronedarone.
ArotinololDronedarone may increase the bradycardic activities of Arotinolol.
Arsenic trioxideArsenic trioxide may increase the QTc-prolonging activities of Dronedarone.
ArtemetherDronedarone may increase the QTc-prolonging activities of Artemether.
AsenapineDronedarone may increase the QTc-prolonging activities of Asenapine.
AstemizoleThe metabolism of Astemizole can be decreased when combined with Dronedarone.
AtazanavirThe serum concentration of Dronedarone can be increased when it is combined with Atazanavir.
AtazanavirThe metabolism of Atazanavir can be decreased when combined with Dronedarone.
AtenololThe serum concentration of Atenolol can be increased when it is combined with Dronedarone.
AtenololAtenolol may increase the bradycardic activities of Dronedarone.
AtomoxetineThe metabolism of Dronedarone can be decreased when combined with Atomoxetine.
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Dronedarone.
AvanafilThe metabolism of Avanafil can be decreased when combined with Dronedarone.
AxitinibThe metabolism of Axitinib can be decreased when combined with Dronedarone.
AzelastineThe metabolism of Azelastine can be decreased when combined with Dronedarone.
AzithromycinAzithromycin may increase the QTc-prolonging activities of Dronedarone.
AzithromycinThe metabolism of Azithromycin can be decreased when combined with Dronedarone.
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Dronedarone.
BedaquilineBedaquiline may increase the QTc-prolonging activities of Dronedarone.
BedaquilineThe metabolism of Bedaquiline can be decreased when combined with Dronedarone.
BefunololDronedarone may increase the bradycardic activities of Befunolol.
BendroflumethiazideBendroflumethiazide may increase the bradycardic activities of Dronedarone.
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Dronedarone.
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Dronedarone.
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Dronedarone.
BepridilThe metabolism of Bepridil can be decreased when combined with Dronedarone.
BeractantDronedarone may increase the bradycardic activities of Beractant.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Dronedarone.
BetaxololBetaxolol may increase the bradycardic activities of Dronedarone.
BevantololDronedarone may increase the bradycardic activities of Bevantolol.
BexaroteneThe serum concentration of Dronedarone can be decreased when it is combined with Bexarotene.
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Dronedarone.
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Dronedarone.
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Dronedarone.
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Dronedarone.
BisoprololBisoprolol may increase the bradycardic activities of Dronedarone.
BoceprevirThe serum concentration of Dronedarone can be increased when it is combined with Boceprevir.
BoceprevirThe metabolism of Boceprevir can be decreased when combined with Dronedarone.
BopindololDronedarone may increase the bradycardic activities of Bopindolol.
BortezomibThe metabolism of Dronedarone can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Dronedarone can be decreased when it is combined with Bosentan.
BosentanThe serum concentration of Bosentan can be increased when it is combined with Dronedarone.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Dronedarone.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Dronedarone.
BretyliumBretylium may increase the bradycardic activities of Dronedarone.
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Dronedarone.
BrinzolamideThe metabolism of Brinzolamide can be decreased when combined with Dronedarone.
BromazepamThe metabolism of Bromazepam can be decreased when combined with Dronedarone.
BromocriptineThe metabolism of Bromocriptine can be decreased when combined with Dronedarone.
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Dronedarone.
BudesonideThe metabolism of Budesonide can be decreased when combined with Dronedarone.
BufuralolThe metabolism of Bufuralol can be decreased when combined with Dronedarone.
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Dronedarone.
BupranololDronedarone may increase the bradycardic activities of Bupranolol.
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Dronedarone.
BupropionThe metabolism of Bupropion can be decreased when combined with Dronedarone.
BuserelinBuserelin may increase the QTc-prolonging activities of Dronedarone.
BuspironeThe metabolism of Buspirone can be decreased when combined with Dronedarone.
BusulfanThe metabolism of Busulfan can be decreased when combined with Dronedarone.
CabazitaxelThe metabolism of Cabazitaxel can be decreased when combined with Dronedarone.
CabergolineThe metabolism of Cabergoline can be decreased when combined with Dronedarone.
CabozantinibThe metabolism of Cabozantinib can be decreased when combined with Dronedarone.
CaffeineThe metabolism of Caffeine can be decreased when combined with Dronedarone.
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Dronedarone.
CalfactantDronedarone may increase the bradycardic activities of Calfactant.
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Dronedarone.
CanagliflozinThe metabolism of Canagliflozin can be decreased when combined with Dronedarone.
CaptoprilThe metabolism of Captopril can be decreased when combined with Dronedarone.
CarbamazepineThe serum concentration of Dronedarone can be decreased when it is combined with Carbamazepine.
CarbamazepineThe metabolism of Carbamazepine can be decreased when combined with Dronedarone.
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Dronedarone.
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Dronedarone.
CariprazineThe metabolism of Cariprazine can be decreased when combined with Dronedarone.
CarteololCarteolol may increase the bradycardic activities of Dronedarone.
CarvedilolThe metabolism of Carvedilol can be decreased when combined with Dronedarone.
CarvedilolCarvedilol may increase the bradycardic activities of Dronedarone.
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Dronedarone.
CeliprololThe metabolism of Celiprolol can be decreased when combined with Dronedarone.
CephalexinThe metabolism of Cephalexin can be decreased when combined with Dronedarone.
CeritinibDronedarone may increase the bradycardic activities of Ceritinib.
CeritinibThe serum concentration of Dronedarone can be increased when it is combined with Ceritinib.
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Dronedarone.
CevimelineThe metabolism of Cevimeline can be decreased when combined with Dronedarone.
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Dronedarone.
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Dronedarone.
ChloroquineChloroquine may increase the QTc-prolonging activities of Dronedarone.
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Dronedarone.
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Dronedarone.
ChlorpromazineChlorpromazine may increase the QTc-prolonging activities of Dronedarone.
ChlorpromazineThe metabolism of Chlorpromazine can be decreased when combined with Dronedarone.
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Dronedarone.
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Dronedarone.
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Dronedarone.
CilostazolThe metabolism of Cilostazol can be decreased when combined with Dronedarone.
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Dronedarone.
CimetidineThe metabolism of Dronedarone can be decreased when combined with Cimetidine.
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Dronedarone.
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Dronedarone.
CiprofloxacinCiprofloxacin may increase the QTc-prolonging activities of Dronedarone.
CiprofloxacinThe serum concentration of Ciprofloxacin can be increased when it is combined with Dronedarone.
CisaprideCisapride may increase the QTc-prolonging activities of Dronedarone.
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Dronedarone.
CitalopramCitalopram may increase the QTc-prolonging activities of Dronedarone.
ClarithromycinThe serum concentration of Dronedarone can be increased when it is combined with Clarithromycin.
ClarithromycinThe metabolism of Clarithromycin can be decreased when combined with Dronedarone.
ClemastineThe metabolism of Dronedarone can be decreased when combined with Clemastine.
ClevidipineThe metabolism of Clevidipine can be decreased when combined with Dronedarone.
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Dronedarone.
ClobazamThe metabolism of Clobazam can be decreased when combined with Dronedarone.
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Dronedarone.
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Dronedarone.
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Dronedarone.
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Dronedarone.
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Dronedarone.
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Dronedarone.
ClonidineThe metabolism of Clonidine can be decreased when combined with Dronedarone.
ClonidineClonidine may increase the bradycardic activities of Dronedarone.
ClopidogrelThe metabolism of Clopidogrel can be decreased when combined with Dronedarone.
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Dronedarone.
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Dronedarone.
ClotrimazoleThe metabolism of Dronedarone can be decreased when combined with Clotrimazole.
ClozapineClozapine may increase the QTc-prolonging activities of Dronedarone.
ClozapineThe metabolism of Clozapine can be decreased when combined with Dronedarone.
CobicistatThe serum concentration of Dronedarone can be increased when it is combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Dronedarone.
CocaineThe metabolism of Cocaine can be decreased when combined with Dronedarone.
CodeineThe therapeutic efficacy of Codeine can be decreased when used in combination with Dronedarone.
ColchicineThe metabolism of Colchicine can be decreased when combined with Dronedarone.
ConivaptanThe serum concentration of Dronedarone can be increased when it is combined with Conivaptan.
ConivaptanThe metabolism of Conivaptan can be decreased when combined with Dronedarone.
Conjugated Equine EstrogensThe metabolism of Conjugated Equine Estrogens can be decreased when combined with Dronedarone.
Cortisone acetateThe metabolism of Cortisone acetate can be decreased when combined with Dronedarone.
CrizotinibCrizotinib may increase the QTc-prolonging activities of Dronedarone.
CrizotinibThe metabolism of Crizotinib can be decreased when combined with Dronedarone.
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Dronedarone.
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Dronedarone.
CyclosporineThe serum concentration of Dronedarone can be increased when it is combined with Cyclosporine.
CyclosporineThe metabolism of Cyclosporine can be decreased when combined with Dronedarone.
CytarabineThe metabolism of Cytarabine can be decreased when combined with Dronedarone.
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be increased when it is combined with Dronedarone.
DabrafenibThe serum concentration of Dronedarone can be decreased when it is combined with Dabrafenib.
DabrafenibThe metabolism of Dabrafenib can be decreased when combined with Dronedarone.
DaclatasvirThe metabolism of Daclatasvir can be decreased when combined with Dronedarone.
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Dronedarone.
DantroleneThe metabolism of Dantrolene can be decreased when combined with Dronedarone.
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Dronedarone.
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Dronedarone.
DapsoneThe metabolism of Dapsone can be decreased when combined with Dronedarone.
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Dronedarone.
DarunavirThe serum concentration of Dronedarone can be increased when it is combined with Darunavir.
DarunavirThe metabolism of Darunavir can be decreased when combined with Dronedarone.
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Dronedarone.
DasatinibThe serum concentration of Dronedarone can be increased when it is combined with Dasatinib.
DasatinibThe metabolism of Dasatinib can be decreased when combined with Dronedarone.
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Dronedarone.
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Dronedarone.
DeferasiroxThe serum concentration of Dronedarone can be decreased when it is combined with Deferasirox.
DegarelixDegarelix may increase the QTc-prolonging activities of Dronedarone.
DehydroepiandrosteroneThe metabolism of Dehydroepiandrosterone can be decreased when combined with Dronedarone.
DelavirdineThe metabolism of Dronedarone can be decreased when combined with Delavirdine.
DesfluraneDesflurane may increase the QTc-prolonging activities of Dronedarone.
DesipramineThe metabolism of Dronedarone can be decreased when combined with Desipramine.
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Dronedarone.
DexamethasoneThe serum concentration of Dronedarone can be decreased when it is combined with Dexamethasone.
DexamethasoneThe metabolism of Dexamethasone can be decreased when combined with Dronedarone.
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Dronedarone.
DexmedetomidineDexmedetomidine may increase the bradycardic activities of Dronedarone.
DexmethylphenidateThe metabolism of Dexmethylphenidate can be decreased when combined with Dronedarone.
DextroamphetamineThe metabolism of Dextroamphetamine can be decreased when combined with Dronedarone.
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Dronedarone.
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Dronedarone.
DiazepamThe metabolism of Diazepam can be decreased when combined with Dronedarone.
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Dronedarone.
DicoumarolThe serum concentration of Dicoumarol can be increased when it is combined with Dronedarone.
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Dronedarone.
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Dronedarone.
DigoxinThe metabolism of Digoxin can be decreased when combined with Dronedarone.
DigoxinDigoxin may increase the bradycardic activities of Dronedarone.
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Dronedarone.
DihydroergotamineThe metabolism of Dronedarone can be decreased when combined with Dihydroergotamine.
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Dronedarone.
DiltiazemThe metabolism of Dronedarone can be decreased when combined with Diltiazem.
DiphenhydramineThe metabolism of Dronedarone can be decreased when combined with Diphenhydramine.
DipyridamoleThe serum concentration of Dipyridamole can be increased when it is combined with Dronedarone.
DisopyramideDisopyramide may increase the QTc-prolonging activities of Dronedarone.
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Dronedarone.
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Dronedarone.
DofetilideDofetilide may increase the QTc-prolonging activities of Dronedarone.
DolasetronDolasetron may increase the QTc-prolonging activities of Dronedarone.
DolasetronThe metabolism of Dolasetron can be decreased when combined with Dronedarone.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Dronedarone.
DomperidoneDomperidone may increase the QTc-prolonging activities of Dronedarone.
DonepezilThe metabolism of Donepezil can be decreased when combined with Dronedarone.
DonepezilDonepezil may increase the bradycardic activities of Dronedarone.
DopamineThe metabolism of Dopamine can be decreased when combined with Dronedarone.
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Dronedarone.
DoxazosinThe metabolism of Doxazosin can be decreased when combined with Dronedarone.
DoxepinThe metabolism of Doxepin can be decreased when combined with Dronedarone.
DoxepinDoxepin may increase the QTc-prolonging activities of Dronedarone.
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Dronedarone.
DoxycyclineThe metabolism of Dronedarone can be decreased when combined with Doxycycline.
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Dronedarone.
DroperidolDroperidol may increase the QTc-prolonging activities of Dronedarone.
DuloxetineThe metabolism of Dronedarone can be decreased when combined with Duloxetine.
DutasterideThe metabolism of Dutasteride can be decreased when combined with Dronedarone.
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Dronedarone.
EfavirenzThe serum concentration of Dronedarone can be decreased when it is combined with Efavirenz.
EfavirenzThe metabolism of Efavirenz can be decreased when combined with Dronedarone.
EletriptanThe metabolism of Eletriptan can be decreased when combined with Dronedarone.
EliglustatDronedarone may increase the QTc-prolonging activities of Eliglustat.
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Dronedarone.
EnalaprilThe metabolism of Enalapril can be decreased when combined with Dronedarone.
EncainideThe metabolism of Encainide can be decreased when combined with Dronedarone.
EnclomipheneThe metabolism of Enclomiphene can be decreased when combined with Dronedarone.
EnzalutamideThe serum concentration of Dronedarone can be decreased when it is combined with Enzalutamide.
EnzalutamideThe metabolism of Enzalutamide can be decreased when combined with Dronedarone.
EpinastineThe metabolism of Epinastine can be decreased when combined with Dronedarone.
EplerenoneThe metabolism of Eplerenone can be decreased when combined with Dronedarone.
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Dronedarone.
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be decreased when combined with Dronedarone.
ErgonovineThe metabolism of Ergonovine can be decreased when combined with Dronedarone.
ErgotamineThe metabolism of Ergotamine can be decreased when combined with Dronedarone.
EribulinEribulin may increase the QTc-prolonging activities of Dronedarone.
ErlotinibThe metabolism of Erlotinib can be decreased when combined with Dronedarone.
ErythromycinErythromycin may increase the QTc-prolonging activities of Dronedarone.
ErythromycinThe metabolism of Erythromycin can be decreased when combined with Dronedarone.
EscitalopramEscitalopram may increase the QTc-prolonging activities of Dronedarone.
Eslicarbazepine acetateThe serum concentration of Dronedarone can be decreased when it is combined with Eslicarbazepine acetate.
EsmirtazapineThe metabolism of Esmirtazapine can be decreased when combined with Dronedarone.
EsmololEsmolol may increase the bradycardic activities of Dronedarone.
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Dronedarone.
EstazolamThe metabolism of Estazolam can be decreased when combined with Dronedarone.
EstradiolThe metabolism of Estradiol can be decreased when combined with Dronedarone.
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Dronedarone.
EstramustineThe metabolism of Estramustine can be decreased when combined with Dronedarone.
EstriolThe serum concentration of Estriol can be increased when it is combined with Dronedarone.
EstroneThe metabolism of Estrone can be decreased when combined with Dronedarone.
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Dronedarone.
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Dronedarone.
EthanolThe metabolism of Ethanol can be decreased when combined with Dronedarone.
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be decreased when combined with Dronedarone.
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Dronedarone.
Ethyl biscoumacetateThe serum concentration of Ethyl biscoumacetate can be increased when it is combined with Dronedarone.
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Dronedarone.
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Dronedarone.
EtoposideThe metabolism of Etoposide can be decreased when combined with Dronedarone.
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Dronedarone.
EtravirineThe serum concentration of Dronedarone can be decreased when it is combined with Etravirine.
EtravirineThe metabolism of Etravirine can be decreased when combined with Dronedarone.
EverolimusThe metabolism of Everolimus can be decreased when combined with Dronedarone.
ExemestaneThe metabolism of Exemestane can be decreased when combined with Dronedarone.
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Dronedarone.
EzogabineEzogabine may increase the QTc-prolonging activities of Dronedarone.
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Dronedarone.
FamotidineFamotidine may increase the QTc-prolonging activities of Dronedarone.
FelbamateThe metabolism of Felbamate can be decreased when combined with Dronedarone.
FelbamateFelbamate may increase the QTc-prolonging activities of Dronedarone.
FelodipineThe metabolism of Felodipine can be decreased when combined with Dronedarone.
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Dronedarone.
FentanylThe metabolism of Fentanyl can be decreased when combined with Dronedarone.
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Dronedarone.
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Dronedarone.
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Dronedarone.
FinasterideThe metabolism of Finasteride can be decreased when combined with Dronedarone.
FingolimodFingolimod may increase the arrhythmogenic activities of Dronedarone.
FingolimodThe metabolism of Fingolimod can be decreased when combined with Dronedarone.
FlecainideFlecainide may increase the QTc-prolonging activities of Dronedarone.
FlecainideThe metabolism of Flecainide can be decreased when combined with Dronedarone.
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Dronedarone.
FluconazoleThe metabolism of Dronedarone can be decreased when combined with Fluconazole.
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Dronedarone.
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Dronedarone.
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Dronedarone.
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Dronedarone.
FluoxetineFluoxetine may increase the QTc-prolonging activities of Dronedarone.
FlupentixolFlupentixol may increase the QTc-prolonging activities of Dronedarone.
FluphenazineThe metabolism of Fluphenazine can be decreased when combined with Dronedarone.
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Dronedarone.
FlutamideThe metabolism of Flutamide can be decreased when combined with Dronedarone.
Fluticasone furoateThe metabolism of Fluticasone furoate can be decreased when combined with Dronedarone.
Fluticasone PropionateThe metabolism of Fluticasone Propionate can be decreased when combined with Dronedarone.
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Dronedarone.
FluvoxamineThe metabolism of Dronedarone can be decreased when combined with Fluvoxamine.
FormoterolFormoterol may increase the QTc-prolonging activities of Dronedarone.
FormoterolThe metabolism of Formoterol can be decreased when combined with Dronedarone.
FosamprenavirThe metabolism of Dronedarone can be decreased when combined with Fosamprenavir.
FosaprepitantThe serum concentration of Dronedarone can be increased when it is combined with Fosaprepitant.
FoscarnetFoscarnet may increase the QTc-prolonging activities of Dronedarone.
FosphenytoinThe serum concentration of Dronedarone can be decreased when it is combined with Fosphenytoin.
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Dronedarone.
Fusidic AcidThe serum concentration of Dronedarone can be increased when it is combined with Fusidic Acid.
Gadobenic acidGadobenic acid may increase the QTc-prolonging activities of Dronedarone.
GalantamineThe metabolism of Galantamine can be decreased when combined with Dronedarone.
GalantamineGalantamine may increase the bradycardic activities of Dronedarone.
GefitinibThe metabolism of Gefitinib can be decreased when combined with Dronedarone.
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Dronedarone.
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Dronedarone.
GemifloxacinGemifloxacin may increase the QTc-prolonging activities of Dronedarone.
GlipizideThe metabolism of Glipizide can be decreased when combined with Dronedarone.
GlyburideThe metabolism of Glyburide can be decreased when combined with Dronedarone.
GoserelinGoserelin may increase the QTc-prolonging activities of Dronedarone.
GranisetronGranisetron may increase the QTc-prolonging activities of Dronedarone.
GranisetronThe metabolism of Granisetron can be decreased when combined with Dronedarone.
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Dronedarone.
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Dronedarone.
GuanfacineThe metabolism of Guanfacine can be decreased when combined with Dronedarone.
GuanfacineGuanfacine may increase the bradycardic activities of Dronedarone.
HalofantrineThe metabolism of Halofantrine can be decreased when combined with Dronedarone.
HaloperidolHaloperidol may increase the QTc-prolonging activities of Dronedarone.
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Dronedarone.
HalothaneThe metabolism of Halothane can be decreased when combined with Dronedarone.
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Dronedarone.
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Dronedarone.
HistrelinHistrelin may increase the QTc-prolonging activities of Dronedarone.
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Dronedarone.
HydrocortisoneThe metabolism of Hydrocortisone can be decreased when combined with Dronedarone.
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Dronedarone.
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Dronedarone.
HydroxyzineHydroxyzine may increase the QTc-prolonging activities of Dronedarone.
IbandronateIbandronate may increase the QTc-prolonging activities of Dronedarone.
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Dronedarone.
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Dronedarone.
IbutilideIbutilide may increase the QTc-prolonging activities of Dronedarone.
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Dronedarone.
IdelalisibThe serum concentration of Dronedarone can be increased when it is combined with Idelalisib.
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Dronedarone resulting in a loss in efficacy.
IloperidoneDronedarone may increase the QTc-prolonging activities of Iloperidone.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Dronedarone.
ImatinibThe metabolism of Dronedarone can be decreased when combined with Imatinib.
ImipramineThe metabolism of Imipramine can be decreased when combined with Dronedarone.
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Dronedarone.
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Dronedarone.
IndacaterolIndacaterol may increase the QTc-prolonging activities of Dronedarone.
IndapamideThe metabolism of Indapamide can be decreased when combined with Dronedarone.
IndapamideIndapamide may increase the QTc-prolonging activities of Dronedarone.
IndenololDronedarone may increase the bradycardic activities of Indenolol.
IndinavirThe serum concentration of Dronedarone can be increased when it is combined with Indinavir.
IndinavirThe metabolism of Indinavir can be decreased when combined with Dronedarone.
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Dronedarone.
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Dronedarone.
IrinotecanThe metabolism of Irinotecan can be decreased when combined with Dronedarone.
IsavuconazoniumThe metabolism of Dronedarone can be decreased when combined with Isavuconazonium.
IsofluraneIsoflurane may increase the QTc-prolonging activities of Dronedarone.
IsoniazidThe metabolism of Dronedarone can be decreased when combined with Isoniazid.
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Dronedarone.
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Dronedarone.
IsradipineThe metabolism of Dronedarone can be decreased when combined with Isradipine.
ItraconazoleThe serum concentration of Dronedarone can be increased when it is combined with Itraconazole.
ItraconazoleThe metabolism of Itraconazole can be decreased when combined with Dronedarone.
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Dronedarone.
IvabradineIvabradine may increase the QTc-prolonging activities of Dronedarone.
IvacaftorThe serum concentration of Dronedarone can be increased when it is combined with Ivacaftor.
IvacaftorThe metabolism of Ivacaftor can be decreased when combined with Dronedarone.
IvermectinThe metabolism of Ivermectin can be decreased when combined with Dronedarone.
IxabepiloneThe metabolism of Ixabepilone can be decreased when combined with Dronedarone.
IxazomibThe metabolism of Ixazomib can be decreased when combined with Dronedarone.
KetamineThe metabolism of Ketamine can be decreased when combined with Dronedarone.
KetazolamThe metabolism of Ketazolam can be decreased when combined with Dronedarone.
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Dronedarone.
KetoconazoleThe serum concentration of Dronedarone can be increased when it is combined with Ketoconazole.
KetoconazoleThe metabolism of Ketoconazole can be decreased when combined with Dronedarone.
LabetalolLabetalol may increase the bradycardic activities of Dronedarone.
LacosamideDronedarone may increase the atrioventricular blocking (AV block) activities of Lacosamide.
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Dronedarone.
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Dronedarone.
LanreotideDronedarone may increase the bradycardic activities of Lanreotide.
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Dronedarone.
LapatinibThe metabolism of Lapatinib can be decreased when combined with Dronedarone.
LapatinibLapatinib may increase the QTc-prolonging activities of Dronedarone.
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Dronedarone.
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Dronedarone.
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Dronedarone.
LenvatinibLenvatinib may increase the QTc-prolonging activities of Dronedarone.
LenvatinibThe metabolism of Lenvatinib can be decreased when combined with Dronedarone.
LercanidipineThe metabolism of Lercanidipine can be decreased when combined with Dronedarone.
LetrozoleThe metabolism of Letrozole can be decreased when combined with Dronedarone.
LeuprolideLeuprolide may increase the QTc-prolonging activities of Dronedarone.
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Dronedarone.
LevobunololLevobunolol may increase the bradycardic activities of Dronedarone.
LevobupivacaineThe metabolism of Levobupivacaine can be decreased when combined with Dronedarone.
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Dronedarone.
LevodopaThe metabolism of Levodopa can be decreased when combined with Dronedarone.
LevofloxacinLevofloxacin may increase the QTc-prolonging activities of Dronedarone.
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Dronedarone.
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Dronedarone.
LevomilnacipranThe metabolism of Levomilnacipran can be decreased when combined with Dronedarone.
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Dronedarone.
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Dronedarone.
LidocaineLidocaine may increase the arrhythmogenic activities of Dronedarone.
LidocaineThe metabolism of Lidocaine can be decreased when combined with Dronedarone.
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Dronedarone.
LisurideThe metabolism of Lisuride can be decreased when combined with Dronedarone.
LithiumLithium may increase the QTc-prolonging activities of Dronedarone.
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Dronedarone.
LomustineThe metabolism of Lomustine can be decreased when combined with Dronedarone.
LoperamideThe metabolism of Loperamide can be decreased when combined with Dronedarone.
LopinavirThe serum concentration of Dronedarone can be increased when it is combined with Lopinavir.
LopinavirDronedarone may increase the QTc-prolonging activities of Lopinavir.
LoratadineThe metabolism of Loratadine can be decreased when combined with Dronedarone.
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Dronedarone.
LosartanThe metabolism of Losartan can be decreased when combined with Dronedarone.
LovastatinThe metabolism of Dronedarone can be decreased when combined with Lovastatin.
LucinactantDronedarone may increase the bradycardic activities of Lucinactant.
LuliconazoleThe serum concentration of Dronedarone can be increased when it is combined with Luliconazole.
LumefantrineDronedarone may increase the QTc-prolonging activities of Lumefantrine.
LurasidoneThe metabolism of Lurasidone can be decreased when combined with Dronedarone.
MacitentanThe metabolism of Macitentan can be decreased when combined with Dronedarone.
MannitolThe serum concentration of Mannitol can be increased when it is combined with Dronedarone.
MaprotilineMaprotiline may increase the QTc-prolonging activities of Dronedarone.
MaprotilineThe metabolism of Maprotiline can be decreased when combined with Dronedarone.
MaravirocThe metabolism of Maraviroc can be decreased when combined with Dronedarone.
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Dronedarone.
Medroxyprogesterone acetateThe metabolism of Medroxyprogesterone acetate can be decreased when combined with Dronedarone.
MefloquineThe metabolism of Mefloquine can be decreased when combined with Dronedarone.
MefloquineMefloquine may increase the QTc-prolonging activities of Dronedarone.
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Dronedarone.
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Dronedarone.
MequitazineThe metabolism of Mequitazine can be decreased when combined with Dronedarone.
MesoridazineThe metabolism of Mesoridazine can be decreased when combined with Dronedarone.
MethadoneMethadone may increase the QTc-prolonging activities of Dronedarone.
MethadoneThe metabolism of Methadone can be decreased when combined with Dronedarone.
MethamphetamineThe metabolism of Methamphetamine can be decreased when combined with Dronedarone.
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Dronedarone.
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Dronedarone.
MethotrimeprazineMethotrimeprazine may increase the QTc-prolonging activities of Dronedarone.
MethotrimeprazineThe metabolism of Methotrimeprazine can be decreased when combined with Dronedarone.
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Dronedarone.
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Dronedarone.
MethyldopaMethyldopa may increase the bradycardic activities of Dronedarone.
MethylphenidateThe metabolism of Methylphenidate can be decreased when combined with Dronedarone.
MethylprednisoloneThe metabolism of Methylprednisolone can be decreased when combined with Dronedarone.
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Dronedarone.
MethyprylonThe metabolism of Methyprylon can be decreased when combined with Dronedarone.
MetipranololMetipranolol may increase the bradycardic activities of Dronedarone.
MetoclopramideMetoclopramide may increase the QTc-prolonging activities of Dronedarone.
MetoclopramideThe metabolism of Metoclopramide can be decreased when combined with Dronedarone.
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Dronedarone.
MetoprololMetoprolol may increase the bradycardic activities of Dronedarone.
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Dronedarone.
MetronidazoleMetronidazole may increase the QTc-prolonging activities of Dronedarone.
MexiletineThe metabolism of Mexiletine can be decreased when combined with Dronedarone.
MianserinThe metabolism of Mianserin can be decreased when combined with Dronedarone.
MibefradilThe metabolism of Mibefradil can be decreased when combined with Dronedarone.
MiconazoleThe metabolism of Miconazole can be decreased when combined with Dronedarone.
MidazolamThe metabolism of Midazolam can be decreased when combined with Dronedarone.
MifepristoneMifepristone may increase the QTc-prolonging activities of Dronedarone.
MinaprineThe metabolism of Minaprine can be decreased when combined with Dronedarone.
MirabegronThe metabolism of Mirabegron can be decreased when combined with Dronedarone.
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Dronedarone.
MirtazapineMirtazapine may increase the QTc-prolonging activities of Dronedarone.
MitotaneThe serum concentration of Dronedarone can be decreased when it is combined with Mitotane.
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Dronedarone.
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Dronedarone.
ModafinilThe serum concentration of Dronedarone can be decreased when it is combined with Modafinil.
ModafinilThe metabolism of Modafinil can be decreased when combined with Dronedarone.
MoexiprilMoexipril may increase the QTc-prolonging activities of Dronedarone.
MontelukastThe metabolism of Montelukast can be decreased when combined with Dronedarone.
MorphineThe metabolism of Morphine can be decreased when combined with Dronedarone.
MoxifloxacinMoxifloxacin may increase the QTc-prolonging activities of Dronedarone.
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Dronedarone.
NadololThe serum concentration of Nadolol can be increased when it is combined with Dronedarone.
NadololNadolol may increase the bradycardic activities of Dronedarone.
NafcillinThe serum concentration of Dronedarone can be decreased when it is combined with Nafcillin.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Dronedarone.
NaloxoneThe metabolism of Naloxone can be decreased when combined with Dronedarone.
NateglinideThe metabolism of Nateglinide can be decreased when combined with Dronedarone.
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Dronedarone.
NebivololNebivolol may increase the bradycardic activities of Dronedarone.
NefazodoneThe serum concentration of Dronedarone can be increased when it is combined with Nefazodone.
NefazodoneThe metabolism of Nefazodone can be decreased when combined with Dronedarone.
NelfinavirThe serum concentration of Dronedarone can be increased when it is combined with Nelfinavir.
NelfinavirThe metabolism of Nelfinavir can be decreased when combined with Dronedarone.
NetupitantThe serum concentration of Dronedarone can be increased when it is combined with Netupitant.
NetupitantThe metabolism of Netupitant can be decreased when combined with Dronedarone.
NevirapineThe serum concentration of Dronedarone can be decreased when it is combined with Nevirapine.
NevirapineThe metabolism of Nevirapine can be decreased when combined with Dronedarone.
NicardipineThe metabolism of Nicardipine can be decreased when combined with Dronedarone.
NicergolineThe metabolism of Nicergoline can be decreased when combined with Dronedarone.
NicotineThe metabolism of Nicotine can be decreased when combined with Dronedarone.
NifedipineThe metabolism of Nifedipine can be decreased when combined with Dronedarone.
NilotinibDronedarone may increase the QTc-prolonging activities of Nilotinib.
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Dronedarone.
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Dronedarone.
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Dronedarone.
NisoldipineThe metabolism of Nisoldipine can be decreased when combined with Dronedarone.
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Dronedarone.
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Dronedarone.
NitrofuralThe metabolism of Nitrofural can be decreased when combined with Dronedarone.
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Dronedarone.
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Dronedarone.
NorfloxacinNorfloxacin may increase the QTc-prolonging activities of Dronedarone.
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Dronedarone.
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Dronedarone.
NortriptylineNortriptyline may increase the QTc-prolonging activities of Dronedarone.
OctreotideOctreotide may increase the bradycardic activities of Dronedarone.
OfloxacinOfloxacin may increase the QTc-prolonging activities of Dronedarone.
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Dronedarone.
OlanzapineOlanzapine may increase the QTc-prolonging activities of Dronedarone.
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Dronedarone.
OlaparibThe metabolism of Dronedarone can be decreased when combined with Olaparib.
OlodaterolOlodaterol may increase the QTc-prolonging activities of Dronedarone.
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Dronedarone.
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Dronedarone.
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Dronedarone.
OndansetronOndansetron may increase the QTc-prolonging activities of Dronedarone.
OndansetronThe metabolism of Ondansetron can be decreased when combined with Dronedarone.
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Dronedarone.
OsimertinibThe serum concentration of Dronedarone can be increased when it is combined with Osimertinib.
OspemifeneThe metabolism of Ospemifene can be decreased when combined with Dronedarone.
OxazepamThe metabolism of Oxazepam can be decreased when combined with Dronedarone.
OxprenololDronedarone may increase the bradycardic activities of Oxprenolol.
OxybutyninThe metabolism of Oxybutynin can be decreased when combined with Dronedarone.
OxycodoneThe metabolism of Oxycodone can be decreased when combined with Dronedarone.
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Dronedarone.
OxytocinOxytocin may increase the QTc-prolonging activities of Dronedarone.
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Dronedarone.
PalbociclibThe serum concentration of Dronedarone can be increased when it is combined with Palbociclib.
PalbociclibThe metabolism of Palbociclib can be decreased when combined with Dronedarone.
PaliperidonePaliperidone may increase the QTc-prolonging activities of Dronedarone.
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Dronedarone.
PanobinostatPanobinostat may increase the QTc-prolonging activities of Dronedarone.
PanobinostatThe metabolism of Panobinostat can be decreased when combined with Dronedarone.
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Dronedarone.
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Dronedarone.
ParamethasoneThe metabolism of Paramethasone can be decreased when combined with Dronedarone.
ParecoxibThe metabolism of Parecoxib can be decreased when combined with Dronedarone.
ParicalcitolThe metabolism of Paricalcitol can be decreased when combined with Dronedarone.
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Dronedarone.
ParoxetineParoxetine may increase the QTc-prolonging activities of Dronedarone.
ParoxetineThe metabolism of Paroxetine can be decreased when combined with Dronedarone.
PasireotideDronedarone may increase the bradycardic activities of Pasireotide.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Dronedarone.
PazopanibPazopanib may increase the QTc-prolonging activities of Dronedarone.
Peginterferon alfa-2bThe serum concentration of Dronedarone can be decreased when it is combined with Peginterferon alfa-2b.
PenbutololPenbutolol may increase the bradycardic activities of Dronedarone.
PentamidinePentamidine may increase the QTc-prolonging activities of Dronedarone.
PentamidineThe metabolism of Pentamidine can be decreased when combined with Dronedarone.
PentobarbitalThe serum concentration of Dronedarone can be decreased when it is combined with Pentobarbital.
PerampanelThe metabolism of Perampanel can be decreased when combined with Dronedarone.
PerflutrenPerflutren may increase the QTc-prolonging activities of Dronedarone.
PergolideThe metabolism of Pergolide can be decreased when combined with Dronedarone.
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Dronedarone.
PermethrinThe metabolism of Permethrin can be decreased when combined with Dronedarone.
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Dronedarone.
PethidineThe metabolism of Pethidine can be decreased when combined with Dronedarone.
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Dronedarone.
PhenforminThe metabolism of Phenformin can be decreased when combined with Dronedarone.
PhenindioneThe serum concentration of Phenindione can be increased when it is combined with Dronedarone.
PhenobarbitalThe serum concentration of Dronedarone can be decreased when it is combined with Phenobarbital.
PhenobarbitalThe serum concentration of Phenobarbital can be increased when it is combined with Dronedarone.
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Dronedarone.
PhenprocoumonThe serum concentration of Phenprocoumon can be increased when it is combined with Dronedarone.
PhenytoinThe serum concentration of Dronedarone can be decreased when it is combined with Phenytoin.
PhenytoinThe metabolism of Phenytoin can be decreased when combined with Dronedarone.
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Dronedarone.
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Dronedarone.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Dronedarone.
PimozidePimozide may increase the QTc-prolonging activities of Dronedarone.
PinacidilThe metabolism of Pinacidil can be decreased when combined with Dronedarone.
PindololPindolol may increase the bradycardic activities of Dronedarone.
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Dronedarone.
PiperazineThe metabolism of Piperazine can be decreased when combined with Dronedarone.
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Dronedarone.
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Dronedarone.
PodofiloxThe metabolism of Podofilox can be decreased when combined with Dronedarone.
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Dronedarone.
PonatinibThe metabolism of Ponatinib can be decreased when combined with Dronedarone.
Poractant alfaDronedarone may increase the bradycardic activities of Poractant alfa.
PosaconazoleThe serum concentration of Dronedarone can be increased when it is combined with Posaconazole.
PosaconazoleThe metabolism of Posaconazole can be decreased when combined with Dronedarone.
PractololDronedarone may increase the bradycardic activities of Practolol.
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Dronedarone.
PravastatinThe metabolism of Pravastatin can be decreased when combined with Dronedarone.
PrazepamThe metabolism of Prazepam can be decreased when combined with Dronedarone.
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Dronedarone.
PrazosinThe serum concentration of Prazosin can be increased when it is combined with Dronedarone.
PrednisoloneThe metabolism of Prednisolone can be decreased when combined with Dronedarone.
PrednisoneThe metabolism of Prednisone can be decreased when combined with Dronedarone.
PrimaquinePrimaquine may increase the QTc-prolonging activities of Dronedarone.
PrimaquineThe metabolism of Primaquine can be decreased when combined with Dronedarone.
PrimidoneThe serum concentration of Dronedarone can be decreased when it is combined with Primidone.
ProcainamideProcainamide may increase the QTc-prolonging activities of Dronedarone.
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Dronedarone.
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Dronedarone.
ProguanilThe metabolism of Proguanil can be decreased when combined with Dronedarone.
PromazinePromazine may increase the QTc-prolonging activities of Dronedarone.
PromazineThe metabolism of Promazine can be decreased when combined with Dronedarone.
PromethazinePromethazine may increase the QTc-prolonging activities of Dronedarone.
PromethazineThe metabolism of Promethazine can be decreased when combined with Dronedarone.
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Dronedarone.
PropafenonePropafenone may increase the arrhythmogenic activities of Dronedarone.
PropofolThe metabolism of Propofol can be decreased when combined with Dronedarone.
PropofolPropofol may increase the QTc-prolonging activities of Dronedarone.
PropranololThe metabolism of Propranolol can be decreased when combined with Dronedarone.
PropranololPropranolol may increase the bradycardic activities of Dronedarone.
ProtriptylineProtriptyline may increase the QTc-prolonging activities of Dronedarone.
ProtriptylineThe metabolism of Protriptyline can be decreased when combined with Dronedarone.
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Dronedarone.
PseudoephedrineThe metabolism of Pseudoephedrine can be decreased when combined with Dronedarone.
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Dronedarone.
QuazepamThe metabolism of Quazepam can be decreased when combined with Dronedarone.
QuetiapineQuetiapine may increase the QTc-prolonging activities of Dronedarone.
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Dronedarone.
QuinidineQuinidine may increase the QTc-prolonging activities of Dronedarone.
QuinineQuinine may increase the QTc-prolonging activities of Dronedarone.
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Dronedarone.
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Dronedarone.
RamelteonThe metabolism of Ramelteon can be decreased when combined with Dronedarone.
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Dronedarone.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Dronedarone.
RanolazineThe metabolism of Dronedarone can be decreased when combined with Ranolazine.
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Dronedarone.
RegorafenibThe metabolism of Regorafenib can be decreased when combined with Dronedarone.
RemoxiprideThe metabolism of Remoxipride can be decreased when combined with Dronedarone.
RepaglinideThe metabolism of Repaglinide can be decreased when combined with Dronedarone.
repinotanThe metabolism of repinotan can be decreased when combined with Dronedarone.
ReserpineThe serum concentration of Reserpine can be increased when it is combined with Dronedarone.
RetapamulinThe metabolism of Retapamulin can be decreased when combined with Dronedarone.
RifabutinThe serum concentration of Dronedarone can be decreased when it is combined with Rifabutin.
RifabutinThe metabolism of Rifabutin can be decreased when combined with Dronedarone.
RifampicinThe serum concentration of Dronedarone can be decreased when it is combined with Rifampicin.
RifampicinThe metabolism of Rifampicin can be decreased when combined with Dronedarone.
RifapentineThe serum concentration of Dronedarone can be decreased when it is combined with Rifapentine.
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Dronedarone.
RilpivirineThe metabolism of Rilpivirine can be decreased when combined with Dronedarone.
RilpivirineRilpivirine may increase the QTc-prolonging activities of Dronedarone.
RimonabantThe metabolism of Rimonabant can be decreased when combined with Dronedarone.
RiociguatThe metabolism of Riociguat can be decreased when combined with Dronedarone.
RisperidoneThe metabolism of Risperidone can be decreased when combined with Dronedarone.
RisperidoneRisperidone may increase the QTc-prolonging activities of Dronedarone.
RitonavirThe serum concentration of Dronedarone can be increased when it is combined with Ritonavir.
RitonavirThe metabolism of Ritonavir can be decreased when combined with Dronedarone.
RivaroxabanThe metabolism of Rivaroxaban can be decreased when combined with Dronedarone.
RivastigmineRivastigmine may increase the bradycardic activities of Dronedarone.
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Dronedarone.
RolapitantThe metabolism of Rolapitant can be decreased when combined with Dronedarone.
RomidepsinThe metabolism of Romidepsin can be decreased when combined with Dronedarone.
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Dronedarone.
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Dronedarone.
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Dronedarone.
RotigotineThe metabolism of Rotigotine can be decreased when combined with Dronedarone.
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Dronedarone.
RuxolitinibRuxolitinib may increase the bradycardic activities of Dronedarone.
RuxolitinibThe metabolism of Ruxolitinib can be decreased when combined with Dronedarone.
SalbutamolSalbutamol may increase the QTc-prolonging activities of Dronedarone.
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Dronedarone.
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Dronedarone.
SalmeterolSalmeterol may increase the QTc-prolonging activities of Dronedarone.
SaquinavirThe serum concentration of Dronedarone can be increased when it is combined with Saquinavir.
SaquinavirThe metabolism of Saquinavir can be decreased when combined with Dronedarone.
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Dronedarone.
SelegilineThe metabolism of Selegiline can be decreased when combined with Dronedarone.
SelexipagThe metabolism of Selexipag can be decreased when combined with Dronedarone.
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Dronedarone.
SertindoleThe metabolism of Sertindole can be decreased when combined with Dronedarone.
SertralineThe metabolism of Sertraline can be decreased when combined with Dronedarone.
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Dronedarone.
SevofluraneSevoflurane may increase the QTc-prolonging activities of Dronedarone.
SibutramineThe metabolism of Sibutramine can be decreased when combined with Dronedarone.
SildenafilThe metabolism of Dronedarone can be decreased when combined with Sildenafil.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Dronedarone.
SiltuximabThe serum concentration of Dronedarone can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Dronedarone can be increased when it is combined with Simeprevir.
SimvastatinThe metabolism of Simvastatin can be decreased when combined with Dronedarone.
SirolimusThe metabolism of Sirolimus can be decreased when combined with Dronedarone.
SitagliptinThe metabolism of Sitagliptin can be decreased when combined with Dronedarone.
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Dronedarone.
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Dronedarone.
SolifenacinSolifenacin may increase the QTc-prolonging activities of Dronedarone.
SonidegibThe metabolism of Sonidegib can be decreased when combined with Dronedarone.
SorafenibThe metabolism of Sorafenib can be decreased when combined with Dronedarone.
SorafenibSorafenib may increase the QTc-prolonging activities of Dronedarone.
SotalolSotalol may increase the QTc-prolonging activities of Dronedarone.
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Dronedarone.
SparteineThe metabolism of Sparteine can be decreased when combined with Dronedarone.
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Dronedarone.
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Dronedarone.
St. John's WortThe serum concentration of Dronedarone can be decreased when it is combined with St. John's Wort.
StiripentolThe serum concentration of Dronedarone can be increased when it is combined with Stiripentol.
SufentanilThe metabolism of Sufentanil can be decreased when combined with Dronedarone.
SufentanilSufentanil may increase the bradycardic activities of Dronedarone.
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Dronedarone.
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Dronedarone.
SulfamethoxazoleSulfamethoxazole may increase the QTc-prolonging activities of Dronedarone.
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Dronedarone.
SulfisoxazoleSulfisoxazole may increase the QTc-prolonging activities of Dronedarone.
SunitinibThe metabolism of Sunitinib can be decreased when combined with Dronedarone.
SunitinibSunitinib may increase the QTc-prolonging activities of Dronedarone.
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Dronedarone.
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Dronedarone.
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Dronedarone.
TacrolimusTacrolimus may increase the QTc-prolonging activities of Dronedarone.
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Dronedarone.
TadalafilThe metabolism of Tadalafil can be decreased when combined with Dronedarone.
TamoxifenThe metabolism of Tamoxifen can be decreased when combined with Dronedarone.
TamoxifenTamoxifen may increase the QTc-prolonging activities of Dronedarone.
TamsulosinThe metabolism of Tamsulosin can be decreased when combined with Dronedarone.
TapentadolThe metabolism of Tapentadol can be decreased when combined with Dronedarone.
TasosartanThe metabolism of Tasosartan can be decreased when combined with Dronedarone.
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Dronedarone.
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Dronedarone.
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Dronedarone.
TegaserodThe metabolism of Tegaserod can be decreased when combined with Dronedarone.
TelaprevirThe serum concentration of Dronedarone can be increased when it is combined with Telaprevir.
TelaprevirThe metabolism of Telaprevir can be decreased when combined with Dronedarone.
TelavancinTelavancin may increase the QTc-prolonging activities of Dronedarone.
TelithromycinThe serum concentration of Dronedarone can be increased when it is combined with Telithromycin.
TelithromycinThe metabolism of Telithromycin can be decreased when combined with Dronedarone.
TemazepamThe metabolism of Temazepam can be decreased when combined with Dronedarone.
TemsirolimusThe metabolism of Temsirolimus can be decreased when combined with Dronedarone.
TeniposideThe metabolism of Teniposide can be decreased when combined with Dronedarone.
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Dronedarone.
TerbutalineTerbutaline may increase the QTc-prolonging activities of Dronedarone.
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Dronedarone.
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Dronedarone.
TestosteroneThe metabolism of Testosterone can be decreased when combined with Dronedarone.
TetrabenazineTetrabenazine may increase the QTc-prolonging activities of Dronedarone.
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Dronedarone.
TheophyllineThe metabolism of Theophylline can be decreased when combined with Dronedarone.
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Dronedarone.
ThioridazineThioridazine may increase the QTc-prolonging activities of Dronedarone.
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Dronedarone.
ThiothixeneThiothixene may increase the QTc-prolonging activities of Dronedarone.
TiagabineThe metabolism of Tiagabine can be decreased when combined with Dronedarone.
TicagrelorThe metabolism of Ticagrelor can be decreased when combined with Dronedarone.
TiclopidineThe metabolism of Dronedarone can be decreased when combined with Ticlopidine.
TimololThe serum concentration of Timolol can be increased when it is combined with Dronedarone.
TimololTimolol may increase the bradycardic activities of Dronedarone.
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Dronedarone.
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Dronedarone.
TipranavirThe metabolism of Tipranavir can be decreased when combined with Dronedarone.
TizanidineTizanidine may increase the bradycardic activities of Dronedarone.
TocilizumabThe serum concentration of Dronedarone can be decreased when it is combined with Tocilizumab.
TofacitinibTofacitinib may increase the bradycardic activities of Dronedarone.
TofacitinibThe metabolism of Tofacitinib can be decreased when combined with Dronedarone.
TolterodineThe metabolism of Tolterodine can be decreased when combined with Dronedarone.
TolterodineTolterodine may increase the QTc-prolonging activities of Dronedarone.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Dronedarone.
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Dronedarone.
ToremifeneToremifene may increase the QTc-prolonging activities of Dronedarone.
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Dronedarone.
TramadolThe therapeutic efficacy of Tramadol can be decreased when used in combination with Dronedarone.
TranylcypromineThe metabolism of Dronedarone can be decreased when combined with Tranylcypromine.
Trastuzumab emtansineThe metabolism of Trastuzumab emtansine can be decreased when combined with Dronedarone.
TrazodoneThe metabolism of Trazodone can be decreased when combined with Dronedarone.
TrazodoneTrazodone may increase the QTc-prolonging activities of Dronedarone.
TreprostinilTreprostinil may increase the QTc-prolonging activities of Dronedarone.
TretinoinThe metabolism of Tretinoin can be decreased when combined with Dronedarone.
TriamcinoloneThe metabolism of Triamcinolone can be decreased when combined with Dronedarone.
TriazolamThe metabolism of Triazolam can be decreased when combined with Dronedarone.
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Dronedarone.
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Dronedarone.
TrimethoprimTrimethoprim may increase the QTc-prolonging activities of Dronedarone.
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Dronedarone.
TrimipramineTrimipramine may increase the QTc-prolonging activities of Dronedarone.
TriptorelinTriptorelin may increase the QTc-prolonging activities of Dronedarone.
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Dronedarone.
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Dronedarone.
UdenafilThe metabolism of Udenafil can be decreased when combined with Dronedarone.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Dronedarone.
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Dronedarone.
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Dronedarone.
VandetanibDronedarone may increase the QTc-prolonging activities of Vandetanib.
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Dronedarone.
VardenafilThe metabolism of Vardenafil can be decreased when combined with Dronedarone.
VardenafilVardenafil may increase the QTc-prolonging activities of Dronedarone.
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Dronedarone.
VemurafenibDronedarone may increase the QTc-prolonging activities of Vemurafenib.
VenlafaxineThe metabolism of Dronedarone can be decreased when combined with Venlafaxine.
VerapamilThe metabolism of Dronedarone can be decreased when combined with Verapamil.
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Dronedarone.
VilanterolThe metabolism of Vilanterol can be decreased when combined with Dronedarone.
VilanterolVilanterol may increase the QTc-prolonging activities of Dronedarone.
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Dronedarone.
VinblastineThe metabolism of Vinblastine can be decreased when combined with Dronedarone.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Dronedarone.
VindesineThe serum concentration of Vindesine can be increased when it is combined with Dronedarone.
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Dronedarone.
VismodegibThe metabolism of Vismodegib can be decreased when combined with Dronedarone.
VoriconazoleThe serum concentration of Dronedarone can be increased when it is combined with Voriconazole.
VoriconazoleThe metabolism of Voriconazole can be decreased when combined with Dronedarone.
VorinostatVorinostat may increase the QTc-prolonging activities of Dronedarone.
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Dronedarone.
WarfarinThe serum concentration of Warfarin can be increased when it is combined with Dronedarone.
YohimbineThe metabolism of Yohimbine can be decreased when combined with Dronedarone.
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Dronedarone.
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Dronedarone.
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Dronedarone.
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Dronedarone.
ZileutonThe metabolism of Zileuton can be decreased when combined with Dronedarone.
ZiprasidoneZiprasidone may increase the QTc-prolonging activities of Dronedarone.
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Dronedarone.
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Dronedarone.
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Dronedarone.
ZopicloneThe metabolism of Zopiclone can be decreased when combined with Dronedarone.
ZuclopenthixolZuclopenthixol may increase the QTc-prolonging activities of Dronedarone.
Food Interactions
  • Absorption of dronedarone increases 3-fold if taken with food especially if meal is high in fat content
  • Do not take dronedarone with grapefruit juice. Grapefruit juice is a potent CYP3A4 inhibitor which will increase serum concentrations of dronedarone threefold

Targets

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Protein heterodimerization activity
Specific Function:
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
Gene Name:
ADRA1A
Uniprot ID:
P35348
Molecular Weight:
51486.005 Da
References
  1. Dale KM, White CM: Dronedarone: an amiodarone analog for the treatment of atrial fibrillation and atrial flutter. Ann Pharmacother. 2007 Apr;41(4):599-605. Epub 2007 Mar 27. [PubMed:17389667 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Protein heterodimerization activity
Specific Function:
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
Gene Name:
ADRA1B
Uniprot ID:
P35368
Molecular Weight:
56835.375 Da
References
  1. Dale KM, White CM: Dronedarone: an amiodarone analog for the treatment of atrial fibrillation and atrial flutter. Ann Pharmacother. 2007 Apr;41(4):599-605. Epub 2007 Mar 27. [PubMed:17389667 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Alpha1-adrenergic receptor activity
Specific Function:
This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.
Gene Name:
ADRA1D
Uniprot ID:
P25100
Molecular Weight:
60462.205 Da
References
  1. Dale KM, White CM: Dronedarone: an amiodarone analog for the treatment of atrial fibrillation and atrial flutter. Ann Pharmacother. 2007 Apr;41(4):599-605. Epub 2007 Mar 27. [PubMed:17389667 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Thioesterase binding
Specific Function:
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianser...
Gene Name:
ADRA2A
Uniprot ID:
P08913
Molecular Weight:
48956.275 Da
References
  1. Dale KM, White CM: Dronedarone: an amiodarone analog for the treatment of atrial fibrillation and atrial flutter. Ann Pharmacother. 2007 Apr;41(4):599-605. Epub 2007 Mar 27. [PubMed:17389667 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Epinephrine binding
Specific Function:
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phent...
Gene Name:
ADRA2B
Uniprot ID:
P18089
Molecular Weight:
49565.8 Da
References
  1. Dale KM, White CM: Dronedarone: an amiodarone analog for the treatment of atrial fibrillation and atrial flutter. Ann Pharmacother. 2007 Apr;41(4):599-605. Epub 2007 Mar 27. [PubMed:17389667 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Protein homodimerization activity
Specific Function:
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
Gene Name:
ADRA2C
Uniprot ID:
P18825
Molecular Weight:
49521.585 Da
References
  1. Dale KM, White CM: Dronedarone: an amiodarone analog for the treatment of atrial fibrillation and atrial flutter. Ann Pharmacother. 2007 Apr;41(4):599-605. Epub 2007 Mar 27. [PubMed:17389667 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Receptor signaling protein activity
Specific Function:
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling.
Gene Name:
ADRB1
Uniprot ID:
P08588
Molecular Weight:
51322.1 Da
References
  1. Dale KM, White CM: Dronedarone: an amiodarone analog for the treatment of atrial fibrillation and atrial flutter. Ann Pharmacother. 2007 Apr;41(4):599-605. Epub 2007 Mar 27. [PubMed:17389667 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
Specific Function:
Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoforms USO have no channel activity by themself, but modulates channel characteristics by forming heterotetramers with other isoforms which are r...
Gene Name:
KCNH2
Uniprot ID:
Q12809
Molecular Weight:
126653.52 Da
References
  1. Iwamoto T, Watanabe Y, Kita S, Blaustein MP: Na+/Ca2+ exchange inhibitors: a new class of calcium regulators. Cardiovasc Hematol Disord Drug Targets. 2007 Sep;7(3):188-98. [PubMed:17896959 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Voltage-gated calcium channel activity
Specific Function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belon...
Gene Name:
CACNA1C
Uniprot ID:
Q13936
Molecular Weight:
248974.1 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Voltage-gated calcium channel activity involved sa node cell action potential
Specific Function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belon...
Gene Name:
CACNA1D
Uniprot ID:
Q01668
Molecular Weight:
245138.75 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Voltage-gated calcium channel activity
Specific Function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1F gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belon...
Gene Name:
CACNA1F
Uniprot ID:
O60840
Molecular Weight:
220675.9 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Voltage-gated calcium channel activity
Specific Function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belon...
Gene Name:
CACNA1S
Uniprot ID:
Q13698
Molecular Weight:
212348.1 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Voltage-gated calcium channel activity
Specific Function:
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
Gene Name:
CACNB1
Uniprot ID:
Q02641
Molecular Weight:
65712.995 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Voltage-gated calcium channel activity
Specific Function:
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
Gene Name:
CACNB2
Uniprot ID:
Q08289
Molecular Weight:
73579.925 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Voltage-gated calcium channel activity
Specific Function:
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
Gene Name:
CACNB3
Uniprot ID:
P54284
Molecular Weight:
54531.425 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Voltage-gated calcium channel activity
Specific Function:
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
Gene Name:
CACNB4
Uniprot ID:
O00305
Molecular Weight:
58168.625 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Voltage-gated sodium channel activity
Specific Function:
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
Gene Name:
SCN1A
Uniprot ID:
P35498
Molecular Weight:
228969.49 Da
References
  1. Lalevee N, Nargeot J, Barrere-Lemaire S, Gautier P, Richard S: Effects of amiodarone and dronedarone on voltage-dependent sodium current in human cardiomyocytes. J Cardiovasc Electrophysiol. 2003 Aug;14(8):885-90. [PubMed:12890054 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Potassium ion leak channel activity
Specific Function:
Ion channel that contributes to passive transmembrane potassium transport (PubMed:23169818). Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner (PubMed:11319556). In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of function...
Gene Name:
KCNK2
Uniprot ID:
O95069
Molecular Weight:
47092.215 Da
References
  1. Schmidt C, Wiedmann F, Schweizer PA, Becker R, Katus HA, Thomas D: Novel electrophysiological properties of dronedarone: inhibition of human cardiac two-pore-domain potassium (K2P) channels. Naunyn Schmiedebergs Arch Pharmacol. 2012 Oct;385(10):1003-16. doi: 10.1007/s00210-012-0780-9. Epub 2012 Jul 13. [PubMed:22790794 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Schafer JA, Kjesbo NK, Gleason PP: Dronedarone: current evidence and future questions. Cardiovasc Ther. 2010 Spring;28(1):38-47. doi: 10.1111/j.1755-5922.2009.00112.x. [PubMed:20074258 ]
  2. De Ferrari GM, Dusi V: Drug safety evaluation of dronedarone in atrial fibrillation. Expert Opin Drug Saf. 2012 Nov;11(6):1023-45. doi: 10.1517/14740338.2012.722994. Epub 2012 Sep 13. [PubMed:22971242 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Dorian P: Clinical pharmacology of dronedarone: implications for the therapy of atrial fibrillation. J Cardiovasc Pharmacol Ther. 2010 Dec;15(4 Suppl):15S-8S. doi: 10.1177/1074248410367792. Epub 2010 May 14. [PubMed:20472816 ]
  2. Schafer JA, Kjesbo NK, Gleason PP: Dronedarone: current evidence and future questions. Cardiovasc Ther. 2010 Spring;28(1):38-47. doi: 10.1111/j.1755-5922.2009.00112.x. [PubMed:20074258 ]
  3. De Ferrari GM, Dusi V: Drug safety evaluation of dronedarone in atrial fibrillation. Expert Opin Drug Saf. 2012 Nov;11(6):1023-45. doi: 10.1517/14740338.2012.722994. Epub 2012 Sep 13. [PubMed:22971242 ]

Carriers

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Toxic substance binding
Specific Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
Gene Name:
ALB
Uniprot ID:
P02768
Molecular Weight:
69365.94 Da

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. De Ferrari GM, Dusi V: Drug safety evaluation of dronedarone in atrial fibrillation. Expert Opin Drug Saf. 2012 Nov;11(6):1023-45. doi: 10.1517/14740338.2012.722994. Epub 2012 Sep 13. [PubMed:22971242 ]
  2. Schafer JA, Kjesbo NK, Gleason PP: Dronedarone: current evidence and future questions. Cardiovasc Ther. 2010 Spring;28(1):38-47. doi: 10.1111/j.1755-5922.2009.00112.x. [PubMed:20074258 ]
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Drug created on October 18, 2007 17:47 / Updated on September 25, 2016 02:16