NAV

Labetuzumab

Identification

Generic Name
Labetuzumab
DrugBank Accession Number
DB05097
Background

Labetuzumab is a humanized monoclonal antibody to carcinoembryonic antigen that inhibits tumor growth. It is used in radioimmunotherapy.

Type
Biotech
Groups
Investigational
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Protein Structure
Protein Chemical Formula
Not Available
Protein Average Weight
Not Available
Sequences
Not Available
Synonyms
  • hMN-14
  • Labetuzumab
  • MAb hMN14
  • MN14 monoclonal antibody to carcinoembryonic antigen
  • Monoclonal antibody hMN-14
External IDs
  • IMMU-100
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Pharmacology

Indication

Labetuzumab is a humanized monoclonal antibody used to treat cancer. Retrieved from "http://en.wikipedia.org/wiki/Labetuzumab"

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action

labetuzumab could significantly increase the chemosensitivity of human colon and breast cancer cells in vitro to several anticancer drugs.

TargetActionsOrganism
UCarcinoembryonic antigen-related cell adhesion molecule 5
inhibitor
Humans
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
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interactions in your software
AbciximabThe risk or severity of adverse effects can be increased when Abciximab is combined with Labetuzumab.
AdalimumabThe risk or severity of adverse effects can be increased when Adalimumab is combined with Labetuzumab.
AducanumabThe risk or severity of adverse effects can be increased when Labetuzumab is combined with Aducanumab.
AlemtuzumabThe risk or severity of adverse effects can be increased when Alemtuzumab is combined with Labetuzumab.
AlirocumabThe risk or severity of adverse effects can be increased when Labetuzumab is combined with Alirocumab.
Food Interactions
Not Available

Products

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International/Other Brands
CEA-Cide

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
Not Available
Kingdom
Organic Compounds
Super Class
Organic Acids
Class
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Peptides
Alternative Parents
Not Available
Substituents
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
EFE6X5M3UY
CAS number
219649-07-7

References

General References
  1. Liersch T, Meller J, Kulle B, Behr TM, Markus P, Langer C, Ghadimi BM, Wegener WA, Kovacs J, Horak ID, Becker H, Goldenberg DM: Phase II trial of carcinoembryonic antigen radioimmunotherapy with 131I-labetuzumab after salvage resection of colorectal metastases in the liver: five-year safety and efficacy results. J Clin Oncol. 2005 Sep 20;23(27):6763-70. [Article]
  2. Liersch T, Meller J, Bittrich M, Kulle B, Becker H, Goldenberg DM: Update of carcinoembryonic antigen radioimmunotherapy with (131)I-labetuzumab after salvage resection of colorectal liver metastases: comparison of outcome to a contemporaneous control group. Ann Surg Oncol. 2007 Sep;14(9):2577-90. Epub 2007 Jun 15. [Article]
PubChem Substance
347909944
Wikipedia
Labetuzumab

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2WithdrawnTreatmentMetastatic Colorectal Cancer (CRC)1
1TerminatedTreatmentColorectal Neoplasms1
1, 2CompletedTreatmentBreast Cancer / Breast Neoplasms / Colon Cancer / Colorectal Cancer / Colorectal Carcinoma (CRC) / Colorectal Neoplasms / Rectal Cancer1
1, 2CompletedTreatmentColon Cancer / Colorectal Cancer / Colorectal Carcinoma (CRC) / Colorectal Neoplasms / Rectal Cancer1
1, 2CompletedTreatmentPancreatic Neoplasms1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available

Targets

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Details1. Carcinoembryonic antigen-related cell adhesion molecule 5
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Protein homodimerization activity
Specific Function
Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins.
Gene Name
CEACAM5
Uniprot ID
P06731
Uniprot Name
Carcinoembryonic antigen-related cell adhesion molecule 5
Molecular Weight
76794.015 Da
References
  1. Govindan SV, Cardillo TM, Moon SJ, Hansen HJ, Goldenberg DM: CEACAM5-targeted therapy of human colonic and pancreatic cancer xenografts with potent labetuzumab-SN-38 immunoconjugates. Clin Cancer Res. 2009 Oct 1;15(19):6052-61. doi: 10.1158/1078-0432.CCR-09-0586. Epub 2009 Sep 29. [Article]

Drug created at October 21, 2007 22:23 / Updated at January 07, 2023 01:39