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Identification
NameSulodexide
Accession NumberDB06271
TypeBiotech
GroupsApproved, Investigational
DescriptionSulodexide is a mixture of glycosaminoglycans (GAGs) composed of dermatan sulfate (DS) and fast moving heparin (FMH).
Protein structureNo structure small
Related Articles
Protein chemical formulaNot Available
Protein average weight6500.0 Da (range 5000-8000)
SequencesNot Available
SynonymsNot Available
External Identifiers
  • KRX-101
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
SulonexNot Available
VesselNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNII75HGV0062C
CAS number57821-29-1
Taxonomy
DescriptionNot Available
KingdomOrganic Compounds
Super ClassOrganic Acids
ClassCarboxylic Acids and Derivatives
Sub ClassAmino Acids, Peptides, and Analogues
Direct ParentPeptides
Alternative ParentsNot Available
SubstituentsNot Available
Molecular FrameworkNot Available
External DescriptorsNot Available
Pharmacology
IndicationSulodexide has been used clinically for the prophylaxis and treatment of vascular diseases with increased risk of thrombosis, including intermittent claudication, peripheral arterial occlusive disease and post-myocardial infarc-tion. Also investigated in the treatment of diabetic kidney disease and diabetic neuropathy. New anti-inflammatory properties have also extended its use in venous disease.
PharmacodynamicsThe low molecular weight of both sulodexide fractions allows for extensive oral absorption compared to unfractionated heparin. The pharmacological effects of sulodexide differ substantially from other glycosaminoglycans and are mainly characterized by a prolonged half-life and reduced effect on global coagulation and bleeding parameters. Due to the presence of both glycosaminoglycan fractions, sulodexide potentiates the antiprotease activities of both antithrombin III and heparin cofactor II simultaneously. It is capable of inhibiting both anti-IIa and anti-Xa. It promotes fibrinolytic activity by releasing tissue plasminogen activator and reduces plasminogen activator inhibitor. The drug also blocks platelet adhesion and platelet function induced by cathepsin G and thrombin. Research has also shown that Sulodexide had endothelial protective properties by inducing the overexpression of growth factors important for the protection of organs. It has anti-inflammatory properties via its effect on the release of inflammatory mediators from macrophages. This results in anti-proliferative effects such as the regulation of growth factors like VEGF and FGF. The intravenous administration has also been shown capable of releasing tissue factor pathway inhibitor from the endothelium, which also contributes to the anti-thrombotic effects of Sulodexide. Lastly, this drug is known for its ability to inhibit the secretion of MMPs, particularly MMP-9, from leukocytes in a dose dependent manner, resulting in the restoration of the balance with their tissue inhibitors.
Mechanism of actionThrombin inhibition produced by sulodexide is due to the additive effect of its components, namely, heparin cofactor II (HCII) catalysis by dermatan sulfate and antithrombin-III catalysis by fast moving heparin (FMH).
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AbsorptionSulodexide can be administered via the oral route, IV and IM routes. After oral dosing, the absorption rate being equivalent, the bioavailability is 40-60%. either calculated from the fast-moving heparin fraction or from the dermatan fraction. Bioavailability following IM administration is approximately 90%. After a rapid absorption in the intestine, the dermatan and heparin components start to appear in the plasma. Sulodexide is degraded after ingestion and loses its sulfate groups and both sulfated and unsulfated groups circulate in the blood for up to 24hours. AUC=22.83+/-4.44mg.h/L.
Volume of distribution

Cmax=516+/-77.54ng/mL,
Tmax=1.33+/-0.58h,
Vd=71.24+/-14.06L (b phase).
Sulodexide reaches high concentrations in the plasma and is widely distributed in the endothelial layer. Binding to endothelial cell receptors in arteries and veins contributes to its rapid distribution profile.

Protein bindingNot Available
Metabolism

It is mainly metabolized in the liver.

Route of eliminationSulodexide is eliminated via the renal, fecal and bile routes. The main clearance occurs renally and accounts for elimination of 55+2.9% of the drug over 96 hours. The fecal and bile routes remove the rest of the drug over 48 hours, which accounts for 23.5+/-2.5% for both routes.
Half lifeThe elimination half-life was 11.7 +/- 2.0 h after intravenous administration, 18.7 +/- 4.1 h after 50 mg per os, and 25.8 +/- 1.9 h after 100 mg per os.
Clearance

2.70+/-0.58L/h

ToxicitySulodexide seems to be well tolerated. Most adverse effects reported are related to the GI system and seem to be transient in nature. Among others adverse reactions are diarrhea, epigastralgia, dyspepsia, heartburn and dizziness. Allergic reactions, such as skin rash, have also been reported but are very rare.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental PropertiesNot Available
References
Synthesis ReferenceNot Available
General References
  1. Cosmi B, Cini M, Legnani C, Pancani C, Calanni F, Coccheri S: Additive thrombin inhibition by fast moving heparin and dermatan sulfate explains the anticoagulant effect of sulodexide, a natural mixture of glycosaminoglycans. Thromb Res. 2003 Mar 15;109(5-6):333-9. [PubMed:12818259 ]
  2. Harenberg J: Review of pharmacodynamics, pharmacokinetics, and therapeutic properties of sulodexide. Med Res Rev. 1998 Jan;18(1):1-20. [PubMed:9436179 ]
  3. Lasierra-Cirujeda J, Coronel P, Aza M, Gimeno M: Use of sulodexide in patients with peripheral vascular disease. J Blood Med. 2010;1:105-15. doi: 10.2147/JBM.S10558. Epub 2010 Jun 15. [PubMed:22282689 ]
  4. Hoppensteadt DA, Fareed J: Pharmacological profile of sulodexide. Int Angiol. 2014 Jun;33(3):229-35. [PubMed:24936531 ]
External Links
ATC CodesB01AB11
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
Interactions
Drug Interactions
Drug
AbciximabAbciximab may increase the anticoagulant activities of Sulodexide.
AceclofenacAceclofenac may increase the anticoagulant activities of Sulodexide.
AcenocoumarolAcenocoumarol may increase the anticoagulant activities of Sulodexide.
Acetylsalicylic acidAcetylsalicylic acid may increase the anticoagulant activities of Sulodexide.
AdapaleneAdapalene may increase the anticoagulant activities of Sulodexide.
AllylestrenolThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Allylestrenol.
AlprostadilAlprostadil may increase the anticoagulant activities of Sulodexide.
AlteplaseAlteplase may increase the anticoagulant activities of Sulodexide.
AltrenogestThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Altrenogest.
ALX-0081ALX-0081 may increase the anticoagulant activities of Sulodexide.
Aminosalicylic AcidAminosalicylic Acid may increase the anticoagulant activities of Sulodexide.
AnagrelideAnagrelide may increase the anticoagulant activities of Sulodexide.
AncrodAncrod may increase the anticoagulant activities of Sulodexide.
AnistreplaseAnistreplase may increase the anticoagulant activities of Sulodexide.
AntipyrineAntipyrine may increase the anticoagulant activities of Sulodexide.
Antithrombin III humanSulodexide may increase the anticoagulant activities of Antithrombin III human.
ApixabanApixaban may increase the anticoagulant activities of Sulodexide.
ApremilastApremilast may increase the anticoagulant activities of Sulodexide.
AprotininThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Aprotinin.
ArdeparinArdeparin may increase the anticoagulant activities of Sulodexide.
ArgatrobanArgatroban may increase the anticoagulant activities of Sulodexide.
AripiprazoleThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Aripiprazole.
Arsenic trioxideThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Arsenic trioxide.
ArticaineThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Articaine.
AsenapineThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Asenapine.
AstaxanthinAstaxanthin may increase the anticoagulant activities of Sulodexide.
AtazanavirThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Atazanavir.
AzapropazoneAzapropazone may increase the anticoagulant activities of Sulodexide.
AzelastineAzelastine may increase the anticoagulant activities of Sulodexide.
BalsalazideBalsalazide may increase the anticoagulant activities of Sulodexide.
BatroxobinBatroxobin may increase the anticoagulant activities of Sulodexide.
BazedoxifeneBazedoxifene may decrease the anticoagulant activities of Sulodexide.
BecaplerminBecaplermin may increase the anticoagulant activities of Sulodexide.
BemiparinBemiparin may increase the anticoagulant activities of Sulodexide.
BendroflumethiazideThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Bendroflumethiazide.
BenoxaprofenBenoxaprofen may increase the anticoagulant activities of Sulodexide.
BeraprostBeraprost may increase the anticoagulant activities of Sulodexide.
BetamethasoneThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Betamethasone.
BivalirudinBivalirudin may increase the anticoagulant activities of Sulodexide.
BrexpiprazoleThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Brexpiprazole.
BromfenacBromfenac may increase the anticoagulant activities of Sulodexide.
BumetanideThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Bumetanide.
BuserelinThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Buserelin.
CangrelorCangrelor may increase the anticoagulant activities of Sulodexide.
CarprofenCarprofen may increase the anticoagulant activities of Sulodexide.
CastanospermineCastanospermine may increase the anticoagulant activities of Sulodexide.
CelecoxibCelecoxib may increase the anticoagulant activities of Sulodexide.
CeritinibThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Ceritinib.
CertoparinSulodexide may increase the anticoagulant activities of Certoparin.
ChloroquineChloroquine may increase the anticoagulant activities of Sulodexide.
ChlorothiazideThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Chlorothiazide.
ChlorotrianiseneChlorotrianisene may decrease the anticoagulant activities of Sulodexide.
ChlorpropamideSulodexide may increase the hypoglycemic activities of Chlorpropamide.
ChlorthalidoneThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Chlorthalidone.
CilostazolCilostazol may increase the anticoagulant activities of Sulodexide.
Citric AcidCitric Acid may increase the anticoagulant activities of Sulodexide.
ClonixinClonixin may increase the anticoagulant activities of Sulodexide.
ClopidogrelClopidogrel may increase the anticoagulant activities of Sulodexide.
ClozapineThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Clozapine.
CollagenaseThe risk or severity of adverse effects can be increased when Sulodexide is combined with Collagenase.
Conjugated Equine EstrogensConjugated Equine Estrogens may decrease the anticoagulant activities of Sulodexide.
CorticotropinThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Corticotropin.
Cortisone acetateThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Cortisone acetate.
Cyproterone acetateThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Cyproterone acetate.
D-LimoneneD-Limonene may increase the anticoagulant activities of Sulodexide.
Dabigatran etexilateDabigatran etexilate may increase the anticoagulant activities of Sulodexide.
DabrafenibThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Dabrafenib.
DalteparinSulodexide may increase the anticoagulant activities of Dalteparin.
DanaparoidSulodexide may increase the anticoagulant activities of Danaparoid.
DanazolThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Danazol.
DarunavirThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Darunavir.
DasatinibDasatinib may increase the anticoagulant activities of Sulodexide.
DeferasiroxThe risk or severity of adverse effects can be increased when Sulodexide is combined with Deferasirox.
DefibrotideDefibrotide may increase the anticoagulant activities of Sulodexide.
Deoxycholic AcidThe risk or severity of adverse effects can be increased when Sulodexide is combined with Deoxycholic Acid.
DesirudinSulodexide may increase the anticoagulant activities of Desirudin.
DesmoteplaseDesmoteplase may increase the anticoagulant activities of Sulodexide.
DesogestrelThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Desogestrel.
DexamethasoneThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Dexamethasone.
DextranSulodexide may increase the anticoagulant activities of Dextran.
Dextran 40Sulodexide may increase the anticoagulant activities of Dextran 40.
Dextran 70Sulodexide may increase the anticoagulant activities of Dextran 70.
Dextran 75Sulodexide may increase the anticoagulant activities of Dextran 75.
DiazoxideThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Diazoxide.
DiclofenacDiclofenac may increase the anticoagulant activities of Sulodexide.
DicoumarolDicoumarol may increase the anticoagulant activities of Sulodexide.
DienestrolDienestrol may decrease the anticoagulant activities of Sulodexide.
DienogestThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Dienogest.
DiethylstilbestrolDiethylstilbestrol may decrease the anticoagulant activities of Sulodexide.
DiflunisalDiflunisal may increase the anticoagulant activities of Sulodexide.
DipyridamoleDipyridamole may increase the anticoagulant activities of Sulodexide.
DisopyramideSulodexide may increase the hypoglycemic activities of Disopyramide.
DitazoleDitazole may increase the anticoagulant activities of Sulodexide.
DrospirenoneThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Drospirenone.
Drotrecogin alfaDrotrecogin alfa may increase the anticoagulant activities of Sulodexide.
DroxicamDroxicam may increase the anticoagulant activities of Sulodexide.
DydrogesteroneThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Dydrogesterone.
Edetic AcidEdetic Acid may increase the anticoagulant activities of Sulodexide.
EdoxabanEdoxaban may increase the anticoagulant activities of Sulodexide.
EnoxaparinEnoxaparin may increase the anticoagulant activities of Sulodexide.
EpinastineEpinastine may increase the anticoagulant activities of Sulodexide.
EpinephrineThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Epinephrine.
EpirizoleEpirizole may increase the anticoagulant activities of Sulodexide.
EpoprostenolEpoprostenol may increase the anticoagulant activities of Sulodexide.
EpoprostenolThe risk or severity of adverse effects can be increased when Sulodexide is combined with Epoprostenol.
EptifibatideEptifibatide may increase the anticoagulant activities of Sulodexide.
EstradiolThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Estradiol.
EstriolEstriol may decrease the anticoagulant activities of Sulodexide.
EstroneEstrone may decrease the anticoagulant activities of Sulodexide.
Estrone sulfateThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Estrone sulfate.
Etacrynic acidThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Etacrynic acid.
EtanerceptEtanercept may increase the anticoagulant activities of Sulodexide.
Ethinyl EstradiolThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Ethinyl Estradiol.
Ethyl biscoumacetateSulodexide may increase the anticoagulant activities of Ethyl biscoumacetate.
Ethynodiol diacetateThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Ethynodiol diacetate.
EtodolacEtodolac may increase the anticoagulant activities of Sulodexide.
EtofenamateEtofenamate may increase the anticoagulant activities of Sulodexide.
EtonogestrelThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Etonogestrel.
EtoricoxibEtoricoxib may increase the anticoagulant activities of Sulodexide.
Evening primrose oilEvening primrose oil may increase the anticoagulant activities of Sulodexide.
EverolimusThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Everolimus.
exisulindexisulind may increase the anticoagulant activities of Sulodexide.
FenbufenFenbufen may increase the anticoagulant activities of Sulodexide.
FenoprofenFenoprofen may increase the anticoagulant activities of Sulodexide.
FibrinolysinFibrinolysin may increase the anticoagulant activities of Sulodexide.
FloctafenineFloctafenine may increase the anticoagulant activities of Sulodexide.
FludrocortisoneThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Fludrocortisone.
FlunixinFlunixin may increase the anticoagulant activities of Sulodexide.
FlurbiprofenFlurbiprofen may increase the anticoagulant activities of Sulodexide.
Fondaparinux sodiumFondaparinux sodium may increase the anticoagulant activities of Sulodexide.
FosamprenavirThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Fosamprenavir.
FurosemideThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Furosemide.
GenisteinGenistein may decrease the anticoagulant activities of Sulodexide.
GestodeneThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Gestodene.
GliclazideSulodexide may increase the hypoglycemic activities of Gliclazide.
GlimepirideSulodexide may increase the hypoglycemic activities of Glimepiride.
GlipizideSulodexide may increase the hypoglycemic activities of Glipizide.
GlyburideSulodexide may increase the hypoglycemic activities of Glyburide.
GoserelinThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Goserelin.
HeminHemin may increase the anticoagulant activities of Sulodexide.
HeparinHeparin may increase the anticoagulant activities of Sulodexide.
HexestrolHexestrol may decrease the anticoagulant activities of Sulodexide.
HirulogHirulog may increase the anticoagulant activities of Sulodexide.
HistrelinThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Histrelin.
HMPL-004HMPL-004 may increase the anticoagulant activities of Sulodexide.
HydrochlorothiazideThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Hydrochlorothiazide.
HydrocortisoneThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Hydrocortisone.
HydroflumethiazideThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Hydroflumethiazide.
Hydroxyprogesterone caproateThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Hydroxyprogesterone caproate.
Ibritumomab tiuxetanThe risk or severity of adverse effects can be increased when Sulodexide is combined with Ibritumomab tiuxetan.
IbrutinibThe risk or severity of adverse effects can be increased when Ibrutinib is combined with Sulodexide.
IbudilastIbudilast may increase the anticoagulant activities of Sulodexide.
IbuprofenIbuprofen may increase the anticoagulant activities of Sulodexide.
IbuproxamIbuproxam may increase the anticoagulant activities of Sulodexide.
IcatibantIcatibant may increase the anticoagulant activities of Sulodexide.
Icosapent ethylIcosapent ethyl may increase the anticoagulant activities of Sulodexide.
IfenprodilIfenprodil may increase the anticoagulant activities of Sulodexide.
IloperidoneThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Iloperidone.
IloprostIloprost may increase the anticoagulant activities of Sulodexide.
IloprostThe risk or severity of adverse effects can be increased when Sulodexide is combined with Iloprost.
IndapamideThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Indapamide.
IndinavirThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Indinavir.
IndomethacinIndomethacin may increase the anticoagulant activities of Sulodexide.
IndoprofenIndoprofen may increase the anticoagulant activities of Sulodexide.
Insulin AspartSulodexide may increase the hypoglycemic activities of Insulin Aspart.
Insulin DetemirSulodexide may increase the hypoglycemic activities of Insulin Detemir.
Insulin GlargineSulodexide may increase the hypoglycemic activities of Insulin Glargine.
Insulin GlulisineSulodexide may increase the hypoglycemic activities of Insulin Glulisine.
Insulin HumanSulodexide may increase the hypoglycemic activities of Insulin Human.
Insulin LisproSulodexide may increase the hypoglycemic activities of Insulin Lispro.
IsoxicamIsoxicam may increase the anticoagulant activities of Sulodexide.
KebuzoneKebuzone may increase the anticoagulant activities of Sulodexide.
KetoprofenKetoprofen may increase the anticoagulant activities of Sulodexide.
KetorolacKetorolac may increase the anticoagulant activities of Sulodexide.
LanreotideThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Lanreotide.
LanreotideSulodexide may increase the hypoglycemic activities of Lanreotide.
LeflunomideLeflunomide may increase the anticoagulant activities of Sulodexide.
LepirudinLepirudin may increase the anticoagulant activities of Sulodexide.
LeuprolideThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Leuprolide.
LevonorgestrelThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Levonorgestrel.
LimaprostThe risk or severity of adverse effects can be increased when Limaprost is combined with Sulodexide.
Lipoic AcidLipoic Acid may increase the hypoglycemic activities of Sulodexide.
LopinavirThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Lopinavir.
LornoxicamLornoxicam may increase the anticoagulant activities of Sulodexide.
LoxoprofenLoxoprofen may increase the anticoagulant activities of Sulodexide.
LumiracoxibLumiracoxib may increase the anticoagulant activities of Sulodexide.
LurasidoneThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Lurasidone.
Magnesium salicylateMagnesium salicylate may increase the anticoagulant activities of Sulodexide.
MasoprocolMasoprocol may increase the anticoagulant activities of Sulodexide.
MecaserminSulodexide may increase the hypoglycemic activities of Mecasermin.
Meclofenamic acidMeclofenamic acid may increase the anticoagulant activities of Sulodexide.
MedrogestoneThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Medrogestone.
Medroxyprogesterone acetateThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Medroxyprogesterone acetate.
Mefenamic acidMefenamic acid may increase the anticoagulant activities of Sulodexide.
Megestrol acetateThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Megestrol acetate.
MeloxicamMeloxicam may increase the anticoagulant activities of Sulodexide.
MesalazineMesalazine may increase the anticoagulant activities of Sulodexide.
MestranolThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Mestranol.
MetamizoleMetamizole may increase the anticoagulant activities of Sulodexide.
MethotrimeprazineThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Methotrimeprazine.
MethyclothiazideThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Methyclothiazide.
MethylprednisoloneThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Methylprednisolone.
MetolazoneThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Metolazone.
MifepristoneSulodexide may increase the hypoglycemic activities of Mifepristone.
MilrinoneMilrinone may increase the anticoagulant activities of Sulodexide.
Mycophenolate mofetilMycophenolate mofetil may increase the anticoagulant activities of Sulodexide.
Mycophenolic acidMycophenolic acid may increase the anticoagulant activities of Sulodexide.
NabumetoneNabumetone may increase the anticoagulant activities of Sulodexide.
NadroparinSulodexide may increase the anticoagulant activities of Nadroparin.
NaftifineNaftifine may increase the anticoagulant activities of Sulodexide.
NaproxenNaproxen may increase the anticoagulant activities of Sulodexide.
NateglinideSulodexide may increase the hypoglycemic activities of Nateglinide.
NCX 4016NCX 4016 may increase the anticoagulant activities of Sulodexide.
NelfinavirThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Nelfinavir.
NepafenacNepafenac may increase the anticoagulant activities of Sulodexide.
NiacinThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Niacin.
Niflumic AcidNiflumic Acid may increase the anticoagulant activities of Sulodexide.
NilotinibThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Nilotinib.
NimesulideNimesulide may increase the anticoagulant activities of Sulodexide.
NintedanibThe risk or severity of adverse effects can be increased when Sulodexide is combined with Nintedanib.
NorethisteroneThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Norethisterone.
NorgestimateThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Norgestimate.
ObinutuzumabThe risk or severity of adverse effects can be increased when Sulodexide is combined with Obinutuzumab.
OctreotideThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Octreotide.
OctreotideSulodexide may increase the hypoglycemic activities of Octreotide.
OlanzapineThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Olanzapine.
OlopatadineOlopatadine may increase the anticoagulant activities of Sulodexide.
OlsalazineOlsalazine may increase the anticoagulant activities of Sulodexide.
Omacetaxine mepesuccinateThe risk or severity of adverse effects can be increased when Sulodexide is combined with Omacetaxine mepesuccinate.
Omega-3 fatty acidsOmega-3 fatty acids may increase the anticoagulant activities of Sulodexide.
OrgoteinOrgotein may increase the anticoagulant activities of Sulodexide.
OtamixabanSulodexide may increase the anticoagulant activities of Otamixaban.
OxaprozinOxaprozin may increase the anticoagulant activities of Sulodexide.
OxyphenbutazoneOxyphenbutazone may increase the anticoagulant activities of Sulodexide.
PaliperidoneThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Paliperidone.
ParecoxibParecoxib may increase the anticoagulant activities of Sulodexide.
ParnaparinParnaparin may increase the anticoagulant activities of Sulodexide.
PasireotideThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Pasireotide.
PasireotideSulodexide may increase the hypoglycemic activities of Pasireotide.
PentamidineThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Pentamidine.
PentamidineSulodexide may increase the hypoglycemic activities of Pentamidine.
Pentosan PolysulfatePentosan Polysulfate may increase the anticoagulant activities of Sulodexide.
PentoxifyllinePentoxifylline may increase the anticoagulant activities of Sulodexide.
PhenindionePhenindione may increase the anticoagulant activities of Sulodexide.
PhenprocoumonPhenprocoumon may increase the anticoagulant activities of Sulodexide.
PhenylbutazonePhenylbutazone may increase the anticoagulant activities of Sulodexide.
PimecrolimusPimecrolimus may increase the anticoagulant activities of Sulodexide.
PiperazineThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Piperazine.
PipotiazineThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Pipotiazine.
PirfenidonePirfenidone may increase the anticoagulant activities of Sulodexide.
PiroxicamPiroxicam may increase the anticoagulant activities of Sulodexide.
PlasminPlasmin may increase the anticoagulant activities of Sulodexide.
Polyestradiol phosphatePolyestradiol phosphate may decrease the anticoagulant activities of Sulodexide.
PolythiazideThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Polythiazide.
PrasugrelPrasugrel may increase the anticoagulant activities of Sulodexide.
PrednisoloneThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Prednisolone.
PrednisoneThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Prednisone.
ProgesteroneThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Progesterone.
PropacetamolPropacetamol may increase the anticoagulant activities of Sulodexide.
Protein CSulodexide may increase the anticoagulant activities of Protein C.
ProtocatechualdehydeSulodexide may increase the anticoagulant activities of Protocatechualdehyde.
PTC299PTC299 may increase the anticoagulant activities of Sulodexide.
QuetiapineThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Quetiapine.
QuinestrolQuinestrol may decrease the anticoagulant activities of Sulodexide.
QuinethazoneThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Quinethazone.
QuinineSulodexide may increase the hypoglycemic activities of Quinine.
RepaglinideSulodexide may increase the hypoglycemic activities of Repaglinide.
ResveratrolResveratrol may increase the anticoagulant activities of Sulodexide.
ReteplaseReteplase may increase the anticoagulant activities of Sulodexide.
ReviparinSulodexide may increase the anticoagulant activities of Reviparin.
RidogrelRidogrel may increase the anticoagulant activities of Sulodexide.
RisperidoneThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Risperidone.
RitonavirThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Ritonavir.
RivaroxabanSulodexide may increase the anticoagulant activities of Rivaroxaban.
RofecoxibRofecoxib may increase the anticoagulant activities of Sulodexide.
RosiglitazoneRosiglitazone may increase the anticoagulant activities of Sulodexide.
SalicylamideSalicylamide may increase the anticoagulant activities of Sulodexide.
Salicylic acidSalicylic acid may increase the anticoagulant activities of Sulodexide.
SalsalateSalsalate may increase the anticoagulant activities of Sulodexide.
SaquinavirThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Saquinavir.
SCH-530348SCH-530348 may increase the anticoagulant activities of Sulodexide.
SelexipagSelexipag may increase the anticoagulant activities of Sulodexide.
SeratrodastSeratrodast may increase the anticoagulant activities of Sulodexide.
SevofluraneSevoflurane may increase the anticoagulant activities of Sulodexide.
SirolimusThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Sirolimus.
SRT501SRT501 may increase the anticoagulant activities of Sulodexide.
StreptokinaseStreptokinase may increase the anticoagulant activities of Sulodexide.
SugammadexSugammadex may increase the anticoagulant activities of Sulodexide.
SulfadiazineSulodexide may increase the hypoglycemic activities of Sulfadiazine.
SulfamethoxazoleSulodexide may increase the hypoglycemic activities of Sulfamethoxazole.
SulfasalazineSulfasalazine may increase the anticoagulant activities of Sulodexide.
SulfisoxazoleSulodexide may increase the hypoglycemic activities of Sulfisoxazole.
SulindacSulindac may increase the anticoagulant activities of Sulodexide.
SunitinibSulodexide may increase the hypoglycemic activities of Sunitinib.
SuprofenSuprofen may increase the anticoagulant activities of Sulodexide.
Synthetic Conjugated Estrogens, ASynthetic Conjugated Estrogens, A may decrease the anticoagulant activities of Sulodexide.
Synthetic Conjugated Estrogens, BSynthetic Conjugated Estrogens, B may decrease the anticoagulant activities of Sulodexide.
TacrolimusThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Tacrolimus.
TemsirolimusThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Temsirolimus.
TenecteplaseTenecteplase may increase the anticoagulant activities of Sulodexide.
TenoxicamTenoxicam may increase the anticoagulant activities of Sulodexide.
TepoxalinTepoxalin may increase the anticoagulant activities of Sulodexide.
TeriflunomideTeriflunomide may increase the anticoagulant activities of Sulodexide.
TesmilifeneTesmilifene may increase the anticoagulant activities of Sulodexide.
Tiaprofenic acidTiaprofenic acid may increase the anticoagulant activities of Sulodexide.
TiboloneTibolone may increase the anticoagulant activities of Sulodexide.
TicagrelorTicagrelor may increase the anticoagulant activities of Sulodexide.
TiclopidineTiclopidine may increase the anticoagulant activities of Sulodexide.
TinzaparinTinzaparin may increase the anticoagulant activities of Sulodexide.
TipranavirTipranavir may increase the anticoagulant activities of Sulodexide.
TirofibanTirofiban may increase the anticoagulant activities of Sulodexide.
TolazamideSulodexide may increase the hypoglycemic activities of Tolazamide.
TolbutamideSulodexide may increase the hypoglycemic activities of Tolbutamide.
Tolfenamic AcidTolfenamic Acid may increase the anticoagulant activities of Sulodexide.
TolmetinTolmetin may increase the anticoagulant activities of Sulodexide.
TorasemideThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Torasemide.
TositumomabThe risk or severity of adverse effects can be increased when Sulodexide is combined with Tositumomab.
TranilastTranilast may increase the anticoagulant activities of Sulodexide.
TrapidilTrapidil may increase the anticoagulant activities of Sulodexide.
TreprostinilTreprostinil may increase the anticoagulant activities of Sulodexide.
TreprostinilThe risk or severity of adverse effects can be increased when Sulodexide is combined with Treprostinil.
TriamcinoloneThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Triamcinolone.
TrichlormethiazideThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Trichlormethiazide.
TriflusalTriflusal may increase the anticoagulant activities of Sulodexide.
TriptorelinThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Triptorelin.
Trisalicylate-cholineTrisalicylate-choline may increase the anticoagulant activities of Sulodexide.
UrokinaseUrokinase may increase the anticoagulant activities of Sulodexide.
ValdecoxibValdecoxib may increase the anticoagulant activities of Sulodexide.
Vitamin EVitamin E may increase the anticoagulant activities of Sulodexide.
VorapaxarThe risk or severity of adverse effects can be increased when Vorapaxar is combined with Sulodexide.
VorinostatThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Vorinostat.
WarfarinWarfarin may increase the anticoagulant activities of Sulodexide.
XimelagatranXimelagatran may increase the anticoagulant activities of Sulodexide.
ZaltoprofenZaltoprofen may increase the anticoagulant activities of Sulodexide.
ZeranolZeranol may decrease the anticoagulant activities of Sulodexide.
ZileutonZileuton may increase the anticoagulant activities of Sulodexide.
ZiprasidoneThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Ziprasidone.
ZomepiracZomepirac may increase the anticoagulant activities of Sulodexide.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Serine-type endopeptidase inhibitor activity
Specific Function:
Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.
Gene Name:
SERPIND1
Uniprot ID:
P05546
Molecular Weight:
57070.16 Da
References
  1. Cosmi B, Cini M, Legnani C, Pancani C, Calanni F, Coccheri S: Additive thrombin inhibition by fast moving heparin and dermatan sulfate explains the anticoagulant effect of sulodexide, a natural mixture of glycosaminoglycans. Thromb Res. 2003 Mar 15;109(5-6):333-9. [PubMed:12818259 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
potentiator
General Function:
Serine-type endopeptidase inhibitor activity
Specific Function:
Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.
Gene Name:
SERPINC1
Uniprot ID:
P01008
Molecular Weight:
52601.935 Da
References
  1. Cosmi B, Cini M, Legnani C, Pancani C, Calanni F, Coccheri S: Additive thrombin inhibition by fast moving heparin and dermatan sulfate explains the anticoagulant effect of sulodexide, a natural mixture of glycosaminoglycans. Thromb Res. 2003 Mar 15;109(5-6):333-9. [PubMed:12818259 ]
  2. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  3. Harenberg J: Review of pharmacodynamics, pharmacokinetics, and therapeutic properties of sulodexide. Med Res Rev. 1998 Jan;18(1):1-20. [PubMed:9436179 ]
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Drug created on March 19, 2008 10:20 / Updated on August 17, 2016 12:24