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Identification
NameIvacaftor
Accession NumberDB08820  (DB05989)
TypeSmall Molecule
GroupsApproved
DescriptionIvacaftor (also known as Kalydeco or VX-770) is a drug for the treatment of cystic fibrosis, developed by Vertex Pharmaceuticals and the Cystic Fibrosis Foundation. FDA approved on January 31, 2012.
Structure
Thumb
Synonyms
Ivacaftorum
Kalydeco
External Identifiers
  • VX-770
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Kalydecotablet, film coated150 mg/1oralVertex Pharmaceuticals Incorporated2012-01-31Not applicableUs
Kalydecogranules50 mgoralVertex Pharmaceuticals (Canada) Incorporated2015-09-14Not applicableCanada
Kalydecogranule50 mg/1oralVertex Pharmaceuticals Incorporated2015-03-23Not applicableUs
Kalydecogranules75 mgoralVertex Pharmaceuticals (Canada) Incorporated2015-09-14Not applicableCanada
Kalydecogranule75 mg/1oralVertex Pharmaceuticals Incorporated2015-03-23Not applicableUs
Kalydecotablet150 mgoralVertex Pharmaceuticals (Canada) Incorporated2012-11-27Not applicableCanada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixtures
NameLabellerIngredients
OrkambiVertex Pharmaceuticals Incorporated
SaltsNot Available
Categories
UNII1Y740ILL1Z
CAS number873054-44-5
WeightAverage: 392.4907
Monoisotopic: 392.209992772
Chemical FormulaC24H28N2O3
InChI KeyInChIKey=PURKAOJPTOLRMP-UHFFFAOYSA-N
InChI
InChI=1S/C24H28N2O3/c1-23(2,3)16-11-17(24(4,5)6)20(27)12-19(16)26-22(29)15-13-25-18-10-8-7-9-14(18)21(15)28/h7-13,27H,1-6H3,(H,25,28)(H,26,29)
IUPAC Name
N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide
SMILES
CC(C)(C)C1=CC(=C(O)C=C1NC(=O)C1=CNC2=CC=CC=C2C1=O)C(C)(C)C
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as quinoline-3-carboxamides. These are quinolines in which the quinoline ring system is substituted by one carboxamide group at the 3-position.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassQuinolines and derivatives
Sub ClassQuinoline carboxamides
Direct ParentQuinoline-3-carboxamides
Alternative Parents
Substituents
  • Quinoline-3-carboxamide
  • Dihydroquinolone
  • N-arylamide
  • Dihydroquinoline
  • Pyridine carboxylic acid or derivatives
  • Phenylpropane
  • Phenol
  • Benzenoid
  • Pyridine
  • Monocyclic benzene moiety
  • Heteroaromatic compound
  • Vinylogous amide
  • Secondary carboxylic acid amide
  • Carboxamide group
  • Azacycle
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of cystic fibrosis (CF) in patients age 6 years and older who have a G551D mutation in the CFTR gene.
PharmacodynamicsIvacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR). In patients with the G551D mutation, Kalydeco, a pill taken two times a day with fat-containing food, helps the protein made by the CFTR gene function better and as a result, improves lung function and other aspects of CF such as increasing weight gain.
Mechanism of actionCystic fibrosis is caused by any one of several defects in a protein, cystic fibrosis transmembrane conductance regulator, which regulates fluid flow within cells and affects the components of sweat, digestive fluids, and mucus. The defect, which is caused by a mutation in the individual's DNA, can be in any of several locations along the protein, each of which interferes with a different function of the protein. One mutation, G551D, lets the CFTR protein reach the epithelial cell surface, but doesn't let it transport chloride through the ion channel. Ivacaftor is a potentiator of the CFTR protein. The CFTR protein is a chloride channel present at the surface of epithelial cells in multiple organs. Ivacaftor facilitates increased chloride transport by potentiating the channel-open probability (or gating) of the G551D-CFTR protein.
Related Articles
AbsorptionThe pharmacokinetics of ivacaftor is similar between healthy adult volunteers and patients with CF. When given a single oral dose of 150 mg to healthy subjects, the parameters were as follows: Tmax = 4 hours; Cmax = 768 ng/mL; AUC = 10600 ng*hr/mL; Time to steady state, 12 hour dosing = 3-5 days Following repeated doses for ivacaftor, accumulation occurs. When given with a fatty meal, exposure increases 2-4 fold.
Volume of distribution

The mean apparent volume of distribution (Vz/F) of ivacaftor after a single dose of 275 mg of Ivacaftor in the fed state was similar for healthy subjects and patients with CF. After oral administration of 150 mg every 12 hours for 7 days to healthy volunteers in a fed state, the mean (±SD) for apparent volume of distribution was 353 (122) L.

Protein bindingIvacaftor is approximately 99% bound to plasma proteins, primarily to alpha 1-acid glycoprotein and albumin. Ivacaftor does not bind to human red blood cells.
Metabolism

Ivacaftor is extensively metabolized in humans. In vitro and clinical studies indicate that ivacaftor is primarily metabolized by CYP3A. M1 and M6 are the two major metabolites of ivacaftor in humans. M1 has approximately one-sixth the potency of ivacaftor and is considered pharmacologically active. M6 has less than one-fiftieth the potency of ivacaftor and is not considered pharmacologically active.

Route of eliminationFollowing oral administration, the majority of ivacaftor (87.8%) is eliminated in the feces after metabolic conversion. The major metabolites M1 and M6 accounted for approximately 65% of the total dose eliminated with 22% as M1 and 43% as M6. There was negligible urinary excretion of ivacaftor as unchanged parent.
Half life12 hours following a single dose
Clearance

The CL/F (SD) for the 150 mg dose was 17.3 (8.4) L/hr in healthy subjects.

ToxicityThere have been no reports of overdose with Ivacaftor. The highest single dose used in a clinical study was 800 mg in a solution formulation without any treatment-related adverse events.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated Effects
Interacting Gene/EnzymeSNP RS IDAllele nameDefining changeEffectReference(s)
Cystic fibrosis transmembrane conductance regulator
Gene symbol: CFTR
UniProt: P13569
rs75527207 Not AvailableA allele (G > A)Cystic Fibrosis patients with the A allele will response to ivacaftor23757359
Cystic fibrosis transmembrane conductance regulator
Gene symbol: CFTR
UniProt: P13569
rs75527207 Not AvailableA allele (G > A)Cystic Fibrosis patients with the A allele will response to ivacaftor23891399
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9577
Blood Brain Barrier+0.6561
Caco-2 permeable-0.5608
P-glycoprotein substrateNon-substrate0.5474
P-glycoprotein inhibitor INon-inhibitor0.7677
P-glycoprotein inhibitor IINon-inhibitor0.7609
Renal organic cation transporterNon-inhibitor0.945
CYP450 2C9 substrateNon-substrate0.7374
CYP450 2D6 substrateNon-substrate0.8362
CYP450 3A4 substrateSubstrate0.5686
CYP450 1A2 substrateInhibitor0.5438
CYP450 2C9 inhibitorInhibitor0.6456
CYP450 2D6 inhibitorNon-inhibitor0.9469
CYP450 2C19 inhibitorNon-inhibitor0.6422
CYP450 3A4 inhibitorNon-inhibitor0.8404
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.5791
Ames testNon AMES toxic0.8394
CarcinogenicityNon-carcinogens0.8149
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.2868 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9961
hERG inhibition (predictor II)Non-inhibitor0.819
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
Granuleoral50 mg/1
Granuleoral75 mg/1
Granulesoral50 mg
Granulesoral75 mg
Tabletoral150 mg
Tablet, film coatedoral150 mg/1
Tabletoral
Tablet, film coatedoral
PricesNot Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US7495103 No2007-05-202027-05-20Us
US8324242 No2007-04-182027-04-18Us
US8354427 No2006-07-062026-07-06Us
US8410274 No2006-12-282026-12-28Us
US8507534 No2010-09-202030-09-20Us
US8653103 No2008-12-042028-12-04Us
US8716338 No2006-11-082026-11-08Us
US8741933 No2006-11-082026-11-08Us
US8754224 No2006-12-282026-12-28Us
US8846718 No2008-12-042028-12-04Us
US8883206 No2013-02-272033-02-27Us
US8993600 No2010-12-112030-12-11Us
US9216969 No2006-11-082026-11-08Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
water solubilityInsoluble (<0.05 µg/mL)FDA label
Predicted Properties
PropertyValueSource
Water Solubility0.002 mg/mLALOGPS
logP5ALOGPS
logP5.76ChemAxon
logS-5.3ALOGPS
pKa (Strongest Acidic)6.57ChemAxon
pKa (Strongest Basic)-0.95ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area78.43 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity118.68 m3·mol-1ChemAxon
Polarizability43.04 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis ReferenceNot Available
General References
  1. Accurso FJ, Rowe SM, Clancy JP, Boyle MP, Dunitz JM, Durie PR, Sagel SD, Hornick DB, Konstan MW, Donaldson SH, Moss RB, Pilewski JM, Rubenstein RC, Uluer AZ, Aitken ML, Freedman SD, Rose LM, Mayer-Hamblett N, Dong Q, Zha J, Stone AJ, Olson ER, Ordonez CL, Campbell PW, Ashlock MA, Ramsey BW: Effect of VX-770 in persons with cystic fibrosis and the G551D-CFTR mutation. N Engl J Med. 2010 Nov 18;363(21):1991-2003. doi: 10.1056/NEJMoa0909825. [PubMed:21083385 ]
  2. Ramsey BW, Davies J, McElvaney NG, Tullis E, Bell SC, Drevinek P, Griese M, McKone EF, Wainwright CE, Konstan MW, Moss R, Ratjen F, Sermet-Gaudelus I, Rowe SM, Dong Q, Rodriguez S, Yen K, Ordonez C, Elborn JS: A CFTR potentiator in patients with cystic fibrosis and the G551D mutation. N Engl J Med. 2011 Nov 3;365(18):1663-72. doi: 10.1056/NEJMoa1105185. [PubMed:22047557 ]
External Links
ATC CodesR07AX30R07AX02
AHFS Codes
  • 48:92
PDB EntriesNot Available
FDA labelDownload (239 KB)
MSDSDownload (353 KB)
Interactions
Drug Interactions
Drug
AbirateroneThe serum concentration of Abiraterone can be increased when it is combined with Ivacaftor.
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Ivacaftor.
AcenocoumarolThe serum concentration of Acenocoumarol can be increased when it is combined with Ivacaftor.
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Ivacaftor.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Ivacaftor.
AdinazolamThe serum concentration of Adinazolam can be increased when it is combined with Ivacaftor.
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Ivacaftor.
AlbendazoleThe serum concentration of Albendazole can be increased when it is combined with Ivacaftor.
AlclometasoneThe serum concentration of Alclometasone can be increased when it is combined with Ivacaftor.
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Ivacaftor.
AlfentanilThe serum concentration of Alfentanil can be increased when it is combined with Ivacaftor.
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Ivacaftor.
AliskirenThe serum concentration of Aliskiren can be increased when it is combined with Ivacaftor.
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Ivacaftor.
AllylestrenolThe serum concentration of Allylestrenol can be increased when it is combined with Ivacaftor.
AlmotriptanThe serum concentration of Almotriptan can be increased when it is combined with Ivacaftor.
AlogliptinThe serum concentration of Alogliptin can be increased when it is combined with Ivacaftor.
AlosetronThe serum concentration of Alosetron can be increased when it is combined with Ivacaftor.
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Ivacaftor.
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Ivacaftor.
AmbroxolThe serum concentration of Ambroxol can be increased when it is combined with Ivacaftor.
AminophenazoneThe serum concentration of Aminophenazone can be increased when it is combined with Ivacaftor.
AminophyllineThe serum concentration of Aminophylline can be increased when it is combined with Ivacaftor.
AmiodaroneThe serum concentration of Amiodarone can be increased when it is combined with Ivacaftor.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Ivacaftor.
AmlodipineThe serum concentration of Amlodipine can be increased when it is combined with Ivacaftor.
AmprenavirThe serum concentration of Amprenavir can be increased when it is combined with Ivacaftor.
AntipyrineThe serum concentration of Antipyrine can be increased when it is combined with Ivacaftor.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Ivacaftor.
ApremilastThe serum concentration of Apremilast can be increased when it is combined with Ivacaftor.
AprepitantThe serum concentration of Ivacaftor can be increased when it is combined with Aprepitant.
ArgatrobanThe serum concentration of Argatroban can be increased when it is combined with Ivacaftor.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Ivacaftor.
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Ivacaftor.
ArtemetherThe serum concentration of Artemether can be increased when it is combined with Ivacaftor.
AsenapineThe serum concentration of Asenapine can be increased when it is combined with Ivacaftor.
AstemizoleThe serum concentration of Astemizole can be increased when it is combined with Ivacaftor.
AtazanavirThe serum concentration of Atazanavir can be increased when it is combined with Ivacaftor.
AtenololThe serum concentration of Atenolol can be increased when it is combined with Ivacaftor.
AtomoxetineThe metabolism of Ivacaftor can be decreased when combined with Atomoxetine.
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Ivacaftor.
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Ivacaftor.
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Ivacaftor.
AzelastineThe serum concentration of Azelastine can be increased when it is combined with Ivacaftor.
AzithromycinThe serum concentration of Azithromycin can be increased when it is combined with Ivacaftor.
BanoxantroneThe serum concentration of Banoxantrone can be increased when it is combined with Ivacaftor.
BedaquilineThe serum concentration of Bedaquiline can be increased when it is combined with Ivacaftor.
BenzphetamineThe serum concentration of Benzphetamine can be increased when it is combined with Ivacaftor.
Benzyl alcoholThe serum concentration of Benzyl alcohol can be increased when it is combined with Ivacaftor.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Ivacaftor.
BexaroteneThe serum concentration of Bexarotene can be increased when it is combined with Ivacaftor.
BexaroteneThe serum concentration of Ivacaftor can be decreased when it is combined with Bexarotene.
BezafibrateThe serum concentration of Bezafibrate can be increased when it is combined with Ivacaftor.
BicalutamideThe serum concentration of Bicalutamide can be increased when it is combined with Ivacaftor.
BisoprololThe serum concentration of Bisoprolol can be increased when it is combined with Ivacaftor.
BoceprevirThe serum concentration of Boceprevir can be increased when it is combined with Ivacaftor.
BortezomibThe serum concentration of Bortezomib can be increased when it is combined with Ivacaftor.
BortezomibThe metabolism of Ivacaftor can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Bosentan can be increased when it is combined with Ivacaftor.
BosentanThe serum concentration of Ivacaftor can be decreased when it is combined with Bosentan.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Ivacaftor.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Ivacaftor.
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Ivacaftor.
BrinzolamideThe serum concentration of Brinzolamide can be increased when it is combined with Ivacaftor.
BromazepamThe serum concentration of Bromazepam can be increased when it is combined with Ivacaftor.
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Ivacaftor.
BrompheniramineThe serum concentration of Brompheniramine can be increased when it is combined with Ivacaftor.
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Ivacaftor.
BupivacaineThe serum concentration of Bupivacaine can be increased when it is combined with Ivacaftor.
BuprenorphineThe serum concentration of Buprenorphine can be increased when it is combined with Ivacaftor.
BupropionThe serum concentration of Bupropion can be increased when it is combined with Ivacaftor.
BuspironeThe serum concentration of Buspirone can be increased when it is combined with Ivacaftor.
BusulfanThe serum concentration of Busulfan can be increased when it is combined with Ivacaftor.
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Ivacaftor.
CabergolineThe serum concentration of Cabergoline can be increased when it is combined with Ivacaftor.
CabozantinibThe serum concentration of Cabozantinib can be increased when it is combined with Ivacaftor.
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Ivacaftor.
CalcitriolThe serum concentration of Calcitriol can be increased when it is combined with Ivacaftor.
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Ivacaftor.
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Ivacaftor.
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Ivacaftor.
CarbamazepineThe serum concentration of Ivacaftor can be decreased when it is combined with Carbamazepine.
CarbinoxamineThe serum concentration of Carbinoxamine can be increased when it is combined with Ivacaftor.
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Ivacaftor.
CariprazineThe serum concentration of Cariprazine can be increased when it is combined with Ivacaftor.
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Ivacaftor.
CelecoxibThe serum concentration of Celecoxib can be increased when it is combined with Ivacaftor.
CeliprololThe serum concentration of Celiprolol can be increased when it is combined with Ivacaftor.
CephalexinThe serum concentration of Cephalexin can be increased when it is combined with Ivacaftor.
CeritinibThe serum concentration of Ivacaftor can be increased when it is combined with Ceritinib.
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Ivacaftor.
CevimelineThe serum concentration of Cevimeline can be increased when it is combined with Ivacaftor.
Chenodeoxycholic acidThe serum concentration of Chenodeoxycholic acid can be increased when it is combined with Ivacaftor.
ChlordiazepoxideThe serum concentration of Chlordiazepoxide can be increased when it is combined with Ivacaftor.
ChloroquineThe serum concentration of Chloroquine can be increased when it is combined with Ivacaftor.
ChlorphenamineThe serum concentration of Chlorphenamine can be increased when it is combined with Ivacaftor.
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Ivacaftor.
ChlorzoxazoneThe serum concentration of Chlorzoxazone can be increased when it is combined with Ivacaftor.
CholecalciferolThe serum concentration of Cholecalciferol can be increased when it is combined with Ivacaftor.
CiclesonideThe serum concentration of Ciclesonide can be increased when it is combined with Ivacaftor.
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Ivacaftor.
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Ivacaftor.
CinacalcetThe serum concentration of Cinacalcet can be increased when it is combined with Ivacaftor.
CiprofloxacinThe serum concentration of Ciprofloxacin can be increased when it is combined with Ivacaftor.
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Ivacaftor.
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Ivacaftor.
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Ivacaftor.
ClarithromycinThe serum concentration of Clarithromycin can be increased when it is combined with Ivacaftor.
ClemastineThe metabolism of Ivacaftor can be decreased when combined with Clemastine.
ClindamycinThe serum concentration of Clindamycin can be increased when it is combined with Ivacaftor.
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Ivacaftor.
ClofazimineThe serum concentration of Clofazimine can be increased when it is combined with Ivacaftor.
ClofibrateThe serum concentration of Clofibrate can be increased when it is combined with Ivacaftor.
clomethiazoleThe serum concentration of clomethiazole can be increased when it is combined with Ivacaftor.
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Ivacaftor.
ClomipramineThe serum concentration of Clomipramine can be increased when it is combined with Ivacaftor.
ClonazepamThe serum concentration of Clonazepam can be increased when it is combined with Ivacaftor.
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Ivacaftor.
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Ivacaftor.
ClorazepateThe serum concentration of Clorazepate can be increased when it is combined with Ivacaftor.
ClotiazepamThe serum concentration of Clotiazepam can be increased when it is combined with Ivacaftor.
ClotrimazoleThe metabolism of Ivacaftor can be decreased when combined with Clotrimazole.
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Ivacaftor.
CobicistatThe serum concentration of Ivacaftor can be increased when it is combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Ivacaftor.
CocaineThe serum concentration of Cocaine can be increased when it is combined with Ivacaftor.
CodeineThe serum concentration of Codeine can be increased when it is combined with Ivacaftor.
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Ivacaftor.
ConivaptanThe serum concentration of Ivacaftor can be increased when it is combined with Conivaptan.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Ivacaftor.
Cortisone acetateThe serum concentration of Cortisone acetate can be increased when it is combined with Ivacaftor.
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Ivacaftor.
CrizotinibThe metabolism of Ivacaftor can be decreased when combined with Crizotinib.
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be increased when it is combined with Ivacaftor.
CyclophosphamideThe serum concentration of Cyclophosphamide can be increased when it is combined with Ivacaftor.
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Ivacaftor.
CyclosporineThe metabolism of Ivacaftor can be decreased when combined with Cyclosporine.
CytarabineThe serum concentration of Cytarabine can be increased when it is combined with Ivacaftor.
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be increased when it is combined with Ivacaftor.
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Ivacaftor.
DabrafenibThe serum concentration of Ivacaftor can be decreased when it is combined with Dabrafenib.
DaclatasvirThe serum concentration of Daclatasvir can be increased when it is combined with Ivacaftor.
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Ivacaftor.
DantroleneThe serum concentration of Dantrolene can be increased when it is combined with Ivacaftor.
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Ivacaftor.
DapsoneThe serum concentration of Dapsone can be increased when it is combined with Ivacaftor.
DarifenacinThe serum concentration of Darifenacin can be increased when it is combined with Ivacaftor.
DarunavirThe serum concentration of Darunavir can be increased when it is combined with Ivacaftor.
DasabuvirThe serum concentration of Dasabuvir can be increased when it is combined with Ivacaftor.
DasatinibThe serum concentration of Ivacaftor can be increased when it is combined with Dasatinib.
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Ivacaftor.
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Ivacaftor.
DeferasiroxThe serum concentration of Ivacaftor can be decreased when it is combined with Deferasirox.
DehydroepiandrosteroneThe serum concentration of Dehydroepiandrosterone can be increased when it is combined with Ivacaftor.
DelavirdineThe serum concentration of Delavirdine can be increased when it is combined with Ivacaftor.
DelavirdineThe metabolism of Ivacaftor can be decreased when combined with Delavirdine.
DesvenlafaxineThe serum concentration of Desvenlafaxine can be increased when it is combined with Ivacaftor.
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Ivacaftor.
DexamethasoneThe serum concentration of Ivacaftor can be decreased when it is combined with Dexamethasone.
DextromethorphanThe serum concentration of Dextromethorphan can be increased when it is combined with Ivacaftor.
DextropropoxypheneThe serum concentration of Dextropropoxyphene can be increased when it is combined with Ivacaftor.
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Ivacaftor.
DiclofenacThe serum concentration of Diclofenac can be increased when it is combined with Ivacaftor.
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Ivacaftor.
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Ivacaftor.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Ivacaftor.
DihydrocodeineThe serum concentration of Dihydrocodeine can be increased when it is combined with Ivacaftor.
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Ivacaftor.
DihydroergotamineThe metabolism of Ivacaftor can be decreased when combined with Dihydroergotamine.
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Ivacaftor.
DiltiazemThe serum concentration of Diltiazem can be increased when it is combined with Ivacaftor.
DiltiazemThe metabolism of Ivacaftor can be decreased when combined with Diltiazem.
DipyridamoleThe serum concentration of Dipyridamole can be increased when it is combined with Ivacaftor.
DisopyramideThe serum concentration of Disopyramide can be increased when it is combined with Ivacaftor.
DisulfiramThe serum concentration of Disulfiram can be increased when it is combined with Ivacaftor.
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Ivacaftor.
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Ivacaftor.
DolasetronThe serum concentration of Dolasetron can be increased when it is combined with Ivacaftor.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Ivacaftor.
DonepezilThe serum concentration of Donepezil can be increased when it is combined with Ivacaftor.
DorzolamideThe serum concentration of Dorzolamide can be increased when it is combined with Ivacaftor.
DoxepinThe serum concentration of Doxepin can be increased when it is combined with Ivacaftor.
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Ivacaftor.
DoxycyclineThe metabolism of Ivacaftor can be decreased when combined with Doxycycline.
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Ivacaftor.
DronedaroneThe serum concentration of Dronedarone can be increased when it is combined with Ivacaftor.
DronedaroneThe metabolism of Ivacaftor can be decreased when combined with Dronedarone.
DutasterideThe serum concentration of Dutasteride can be increased when it is combined with Ivacaftor.
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Ivacaftor.
EfavirenzThe serum concentration of Efavirenz can be increased when it is combined with Ivacaftor.
EfavirenzThe serum concentration of Ivacaftor can be decreased when it is combined with Efavirenz.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Ivacaftor.
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Ivacaftor.
ElvitegravirThe serum concentration of Elvitegravir can be increased when it is combined with Ivacaftor.
EnalaprilThe serum concentration of Enalapril can be increased when it is combined with Ivacaftor.
EnzalutamideThe serum concentration of Enzalutamide can be increased when it is combined with Ivacaftor.
EnzalutamideThe serum concentration of Ivacaftor can be decreased when it is combined with Enzalutamide.
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Ivacaftor.
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Ivacaftor.
ErgocalciferolThe serum concentration of Ergocalciferol can be increased when it is combined with Ivacaftor.
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Ivacaftor.
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Ivacaftor.
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Ivacaftor.
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Ivacaftor.
ErythromycinThe serum concentration of Erythromycin can be increased when it is combined with Ivacaftor.
ErythromycinThe metabolism of Ivacaftor can be decreased when combined with Erythromycin.
EscitalopramThe serum concentration of Escitalopram can be increased when it is combined with Ivacaftor.
Eslicarbazepine acetateThe serum concentration of Ivacaftor can be decreased when it is combined with Eslicarbazepine acetate.
EsomeprazoleThe serum concentration of Esomeprazole can be increased when it is combined with Ivacaftor.
EstazolamThe serum concentration of Estazolam can be increased when it is combined with Ivacaftor.
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Ivacaftor.
Estradiol valerate/DienogestThe serum concentration of Estradiol valerate/Dienogest can be increased when it is combined with Ivacaftor.
EstramustineThe serum concentration of Estramustine can be increased when it is combined with Ivacaftor.
EstriolThe serum concentration of Estriol can be increased when it is combined with Ivacaftor.
EstroneThe serum concentration of Estrone can be increased when it is combined with Ivacaftor.
Estrone sulfateThe serum concentration of Estrone sulfate can be increased when it is combined with Ivacaftor.
EszopicloneThe serum concentration of Eszopiclone can be increased when it is combined with Ivacaftor.
EthanolThe serum concentration of Ethanol can be increased when it is combined with Ivacaftor.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Ivacaftor.
EthosuximideThe serum concentration of Ethosuximide can be increased when it is combined with Ivacaftor.
EthylmorphineThe serum concentration of Ethylmorphine can be increased when it is combined with Ivacaftor.
EtonogestrelThe serum concentration of Etonogestrel can be increased when it is combined with Ivacaftor.
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Ivacaftor.
EtoricoxibThe serum concentration of Etoricoxib can be increased when it is combined with Ivacaftor.
EtravirineThe serum concentration of Etravirine can be increased when it is combined with Ivacaftor.
EtravirineThe serum concentration of Ivacaftor can be decreased when it is combined with Etravirine.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Ivacaftor.
ExemestaneThe serum concentration of Exemestane can be increased when it is combined with Ivacaftor.
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Ivacaftor.
FamciclovirThe serum concentration of Famciclovir can be increased when it is combined with Ivacaftor.
FelbamateThe serum concentration of Felbamate can be increased when it is combined with Ivacaftor.
FelodipineThe serum concentration of Felodipine can be increased when it is combined with Ivacaftor.
FenofibrateThe serum concentration of Fenofibrate can be increased when it is combined with Ivacaftor.
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Ivacaftor.
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Ivacaftor.
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Ivacaftor.
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Ivacaftor.
FinasterideThe serum concentration of Finasteride can be increased when it is combined with Ivacaftor.
FingolimodThe serum concentration of Fingolimod can be increased when it is combined with Ivacaftor.
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Ivacaftor.
FluconazoleThe metabolism of Ivacaftor can be decreased when combined with Fluconazole.
FlunisolideThe serum concentration of Flunisolide can be increased when it is combined with Ivacaftor.
FlunitrazepamThe serum concentration of Flunitrazepam can be increased when it is combined with Ivacaftor.
FluorometholoneThe serum concentration of Fluorometholone can be increased when it is combined with Ivacaftor.
FluoxetineThe serum concentration of Fluoxetine can be increased when it is combined with Ivacaftor.
FlurazepamThe serum concentration of Flurazepam can be increased when it is combined with Ivacaftor.
FlutamideThe serum concentration of Flutamide can be increased when it is combined with Ivacaftor.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Ivacaftor.
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be increased when it is combined with Ivacaftor.
FluvastatinThe serum concentration of Fluvastatin can be increased when it is combined with Ivacaftor.
FluvoxamineThe metabolism of Ivacaftor can be decreased when combined with Fluvoxamine.
FosamprenavirThe serum concentration of Fosamprenavir can be increased when it is combined with Ivacaftor.
FosamprenavirThe metabolism of Ivacaftor can be decreased when combined with Fosamprenavir.
FosaprepitantThe serum concentration of Ivacaftor can be increased when it is combined with Fosaprepitant.
FosphenytoinThe serum concentration of Ivacaftor can be decreased when it is combined with Fosphenytoin.
FulvestrantThe serum concentration of Fulvestrant can be increased when it is combined with Ivacaftor.
Fusidic AcidThe serum concentration of Ivacaftor can be increased when it is combined with Fusidic Acid.
GalantamineThe serum concentration of Galantamine can be increased when it is combined with Ivacaftor.
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Ivacaftor.
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Ivacaftor.
GemfibrozilThe serum concentration of Gemfibrozil can be increased when it is combined with Ivacaftor.
GlipizideThe serum concentration of Glipizide can be increased when it is combined with Ivacaftor.
GlyburideThe serum concentration of Glyburide can be increased when it is combined with Ivacaftor.
GranisetronThe serum concentration of Granisetron can be increased when it is combined with Ivacaftor.
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Ivacaftor.
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Ivacaftor.
GuanfacineThe serum concentration of Guanfacine can be increased when it is combined with Ivacaftor.
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Ivacaftor.
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Ivacaftor.
HalothaneThe serum concentration of Halothane can be increased when it is combined with Ivacaftor.
HexobarbitalThe serum concentration of Hexobarbital can be increased when it is combined with Ivacaftor.
Histamine PhosphateThe serum concentration of Histamine Phosphate can be increased when it is combined with Ivacaftor.
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Ivacaftor.
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Ivacaftor.
HydromorphoneThe serum concentration of Hydromorphone can be increased when it is combined with Ivacaftor.
Hydroxyprogesterone caproateThe serum concentration of Hydroxyprogesterone caproate can be increased when it is combined with Ivacaftor.
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Ivacaftor.
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Ivacaftor.
IdelalisibThe serum concentration of Ivacaftor can be increased when it is combined with Idelalisib.
IfosfamideThe serum concentration of Ifosfamide can be increased when it is combined with Ivacaftor.
IloperidoneThe serum concentration of Iloperidone can be increased when it is combined with Ivacaftor.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Ivacaftor.
ImatinibThe metabolism of Ivacaftor can be decreased when combined with Imatinib.
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Ivacaftor.
ImiquimodThe serum concentration of Imiquimod can be increased when it is combined with Ivacaftor.
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Ivacaftor.
IndapamideThe serum concentration of Indapamide can be increased when it is combined with Ivacaftor.
IndinavirThe serum concentration of Indinavir can be increased when it is combined with Ivacaftor.
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Ivacaftor.
Ipratropium bromideThe serum concentration of Ipratropium bromide can be increased when it is combined with Ivacaftor.
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Ivacaftor.
IsavuconazoniumThe serum concentration of Isavuconazonium can be increased when it is combined with Ivacaftor.
IsavuconazoniumThe metabolism of Ivacaftor can be decreased when combined with Isavuconazonium.
Isosorbide DinitrateThe serum concentration of Isosorbide Dinitrate can be increased when it is combined with Ivacaftor.
Isosorbide MononitrateThe serum concentration of Isosorbide Mononitrate can be increased when it is combined with Ivacaftor.
IsradipineThe serum concentration of Isradipine can be increased when it is combined with Ivacaftor.
IsradipineThe metabolism of Ivacaftor can be decreased when combined with Isradipine.
ItraconazoleThe serum concentration of Itraconazole can be increased when it is combined with Ivacaftor.
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Ivacaftor.
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Ivacaftor.
IxabepiloneThe serum concentration of Ixabepilone can be increased when it is combined with Ivacaftor.
IxazomibThe serum concentration of Ixazomib can be increased when it is combined with Ivacaftor.
KetamineThe serum concentration of Ketamine can be increased when it is combined with Ivacaftor.
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Ivacaftor.
KetobemidoneThe serum concentration of Ketobemidone can be increased when it is combined with Ivacaftor.
KetoconazoleThe serum concentration of Ketoconazole can be increased when it is combined with Ivacaftor.
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Ivacaftor.
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Ivacaftor.
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Ivacaftor.
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Ivacaftor.
LaquinimodThe serum concentration of Laquinimod can be increased when it is combined with Ivacaftor.
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Ivacaftor.
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Ivacaftor.
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Ivacaftor.
LercanidipineThe serum concentration of Lercanidipine can be increased when it is combined with Ivacaftor.
LetrozoleThe serum concentration of Letrozole can be increased when it is combined with Ivacaftor.
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Ivacaftor.
LevobupivacaineThe serum concentration of Levobupivacaine can be increased when it is combined with Ivacaftor.
LevocetirizineThe serum concentration of Levocetirizine can be increased when it is combined with Ivacaftor.
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Ivacaftor.
Levomethadyl AcetateThe serum concentration of Levomethadyl Acetate can be increased when it is combined with Ivacaftor.
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Ivacaftor.
LevonorgestrelThe serum concentration of Levonorgestrel can be increased when it is combined with Ivacaftor.
LevothyroxineThe serum concentration of Levothyroxine can be increased when it is combined with Ivacaftor.
LidocaineThe serum concentration of Lidocaine can be increased when it is combined with Ivacaftor.
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Ivacaftor.
LisurideThe serum concentration of Lisuride can be increased when it is combined with Ivacaftor.
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Ivacaftor.
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Ivacaftor.
LopinavirThe serum concentration of Lopinavir can be increased when it is combined with Ivacaftor.
LoratadineThe serum concentration of Loratadine can be increased when it is combined with Ivacaftor.
LorcaserinThe serum concentration of Lorcaserin can be increased when it is combined with Ivacaftor.
LosartanThe serum concentration of Losartan can be increased when it is combined with Ivacaftor.
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Ivacaftor.
LovastatinThe metabolism of Ivacaftor can be decreased when combined with Lovastatin.
LuliconazoleThe serum concentration of Ivacaftor can be increased when it is combined with Luliconazole.
LumefantrineThe serum concentration of Lumefantrine can be increased when it is combined with Ivacaftor.
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Ivacaftor.
MacitentanThe serum concentration of Macitentan can be increased when it is combined with Ivacaftor.
MannitolThe serum concentration of Mannitol can be increased when it is combined with Ivacaftor.
MaravirocThe serum concentration of Maraviroc can be increased when it is combined with Ivacaftor.
MebendazoleThe serum concentration of Mebendazole can be increased when it is combined with Ivacaftor.
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be increased when it is combined with Ivacaftor.
MefloquineThe serum concentration of Mefloquine can be increased when it is combined with Ivacaftor.
MeloxicamThe serum concentration of Meloxicam can be increased when it is combined with Ivacaftor.
MethadoneThe serum concentration of Methadone can be increased when it is combined with Ivacaftor.
MethaqualoneThe serum concentration of Methaqualone can be increased when it is combined with Ivacaftor.
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Ivacaftor.
MethoxsalenThe serum concentration of Methoxsalen can be increased when it is combined with Ivacaftor.
MethoxyfluraneThe serum concentration of Methoxyflurane can be increased when it is combined with Ivacaftor.
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Ivacaftor.
MethyltestosteroneThe serum concentration of Methyltestosterone can be increased when it is combined with Ivacaftor.
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Ivacaftor.
MetronidazoleThe serum concentration of Metronidazole can be increased when it is combined with Ivacaftor.
MexiletineThe serum concentration of Mexiletine can be increased when it is combined with Ivacaftor.
MianserinThe serum concentration of Mianserin can be increased when it is combined with Ivacaftor.
MibefradilThe serum concentration of Mibefradil can be increased when it is combined with Ivacaftor.
MiconazoleThe serum concentration of Miconazole can be increased when it is combined with Ivacaftor.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Ivacaftor.
MifepristoneThe serum concentration of Mifepristone can be increased when it is combined with Ivacaftor.
MifepristoneThe metabolism of Ivacaftor can be decreased when combined with Mifepristone.
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Ivacaftor.
MirtazapineThe serum concentration of Mirtazapine can be increased when it is combined with Ivacaftor.
MitotaneThe serum concentration of Ivacaftor can be decreased when it is combined with Mitotane.
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Ivacaftor.
ModafinilThe serum concentration of Modafinil can be increased when it is combined with Ivacaftor.
ModafinilThe serum concentration of Ivacaftor can be decreased when it is combined with Modafinil.
MontelukastThe serum concentration of Montelukast can be increased when it is combined with Ivacaftor.
MorphineThe serum concentration of Morphine can be increased when it is combined with Ivacaftor.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Ivacaftor.
NadololThe serum concentration of Nadolol can be increased when it is combined with Ivacaftor.
NafcillinThe serum concentration of Ivacaftor can be decreased when it is combined with Nafcillin.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Ivacaftor.
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Ivacaftor.
NateglinideThe serum concentration of Nateglinide can be increased when it is combined with Ivacaftor.
NefazodoneThe serum concentration of Nefazodone can be increased when it is combined with Ivacaftor.
NelfinavirThe serum concentration of Nelfinavir can be increased when it is combined with Ivacaftor.
NetupitantThe serum concentration of Ivacaftor can be increased when it is combined with Netupitant.
NevirapineThe serum concentration of Nevirapine can be increased when it is combined with Ivacaftor.
NevirapineThe serum concentration of Ivacaftor can be decreased when it is combined with Nevirapine.
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Ivacaftor.
NicotineThe serum concentration of Nicotine can be increased when it is combined with Ivacaftor.
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Ivacaftor.
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Ivacaftor.
NilotinibThe metabolism of Ivacaftor can be decreased when combined with Nilotinib.
NilvadipineThe serum concentration of Nilvadipine can be increased when it is combined with Ivacaftor.
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Ivacaftor.
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Ivacaftor.
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Ivacaftor.
NitrazepamThe serum concentration of Nitrazepam can be increased when it is combined with Ivacaftor.
NitrendipineThe serum concentration of Nitrendipine can be increased when it is combined with Ivacaftor.
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Ivacaftor.
NorethisteroneThe serum concentration of Norethisterone can be increased when it is combined with Ivacaftor.
NorgestrelThe serum concentration of Norgestrel can be increased when it is combined with Ivacaftor.
NortriptylineThe serum concentration of Nortriptyline can be increased when it is combined with Ivacaftor.
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Ivacaftor.
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Ivacaftor.
OlaparibThe metabolism of Ivacaftor can be decreased when combined with Olaparib.
OlopatadineThe serum concentration of Olopatadine can be increased when it is combined with Ivacaftor.
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Ivacaftor.
OmeprazoleThe serum concentration of Omeprazole can be increased when it is combined with Ivacaftor.
OndansetronThe serum concentration of Ondansetron can be increased when it is combined with Ivacaftor.
OrphenadrineThe serum concentration of Orphenadrine can be increased when it is combined with Ivacaftor.
OsimertinibThe serum concentration of Ivacaftor can be increased when it is combined with Osimertinib.
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Ivacaftor.
OxazepamThe serum concentration of Oxazepam can be increased when it is combined with Ivacaftor.
OxybutyninThe serum concentration of Oxybutynin can be increased when it is combined with Ivacaftor.
OxycodoneThe serum concentration of Oxycodone can be increased when it is combined with Ivacaftor.
OxymorphoneThe serum concentration of Oxymorphone can be increased when it is combined with Ivacaftor.
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Ivacaftor.
PalbociclibThe serum concentration of Palbociclib can be increased when it is combined with Ivacaftor.
PalonosetronThe serum concentration of Palonosetron can be increased when it is combined with Ivacaftor.
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Ivacaftor.
PantoprazoleThe serum concentration of Pantoprazole can be increased when it is combined with Ivacaftor.
ParamethadioneThe serum concentration of Paramethadione can be increased when it is combined with Ivacaftor.
ParamethasoneThe serum concentration of Paramethasone can be increased when it is combined with Ivacaftor.
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Ivacaftor.
ParicalcitolThe serum concentration of Paricalcitol can be increased when it is combined with Ivacaftor.
ParitaprevirThe serum concentration of Paritaprevir can be increased when it is combined with Ivacaftor.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Ivacaftor.
PentamidineThe serum concentration of Pentamidine can be increased when it is combined with Ivacaftor.
PentobarbitalThe serum concentration of Ivacaftor can be decreased when it is combined with Pentobarbital.
PerampanelThe serum concentration of Perampanel can be increased when it is combined with Ivacaftor.
PergolideThe serum concentration of Pergolide can be increased when it is combined with Ivacaftor.
PerhexilineThe serum concentration of Perhexiline can be increased when it is combined with Ivacaftor.
PermethrinThe serum concentration of Permethrin can be increased when it is combined with Ivacaftor.
PerphenazineThe serum concentration of Perphenazine can be increased when it is combined with Ivacaftor.
PethidineThe serum concentration of Pethidine can be increased when it is combined with Ivacaftor.
PhenacetinThe serum concentration of Phenacetin can be increased when it is combined with Ivacaftor.
PhenobarbitalThe serum concentration of Ivacaftor can be decreased when it is combined with Phenobarbital.
PhenobarbitalThe serum concentration of Phenobarbital can be increased when it is combined with Ivacaftor.
PhenoxybenzamineThe serum concentration of Phenoxybenzamine can be increased when it is combined with Ivacaftor.
PhenprocoumonThe serum concentration of Phenprocoumon can be increased when it is combined with Ivacaftor.
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Ivacaftor.
PhenytoinThe serum concentration of Ivacaftor can be decreased when it is combined with Phenytoin.
PilocarpineThe serum concentration of Pilocarpine can be increased when it is combined with Ivacaftor.
PimecrolimusThe serum concentration of Pimecrolimus can be increased when it is combined with Ivacaftor.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Ivacaftor.
PinacidilThe serum concentration of Pinacidil can be increased when it is combined with Ivacaftor.
PioglitazoneThe serum concentration of Pioglitazone can be increased when it is combined with Ivacaftor.
PipotiazineThe serum concentration of Pipotiazine can be increased when it is combined with Ivacaftor.
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Ivacaftor.
PodofiloxThe serum concentration of Podofilox can be increased when it is combined with Ivacaftor.
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Ivacaftor.
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Ivacaftor.
PosaconazoleThe serum concentration of Posaconazole can be increased when it is combined with Ivacaftor.
PrasugrelThe serum concentration of Prasugrel can be increased when it is combined with Ivacaftor.
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Ivacaftor.
PrazepamThe serum concentration of Prazepam can be increased when it is combined with Ivacaftor.
PraziquantelThe serum concentration of Praziquantel can be increased when it is combined with Ivacaftor.
PrazosinThe serum concentration of Prazosin can be increased when it is combined with Ivacaftor.
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Ivacaftor.
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Ivacaftor.
PrimaquineThe serum concentration of Primaquine can be increased when it is combined with Ivacaftor.
PrimidoneThe serum concentration of Ivacaftor can be decreased when it is combined with Primidone.
ProchlorperazineThe serum concentration of Prochlorperazine can be increased when it is combined with Ivacaftor.
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Ivacaftor.
ProguanilThe serum concentration of Proguanil can be increased when it is combined with Ivacaftor.
PromazineThe serum concentration of Promazine can be increased when it is combined with Ivacaftor.
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Ivacaftor.
PropofolThe serum concentration of Propofol can be increased when it is combined with Ivacaftor.
PropranololThe serum concentration of Propranolol can be increased when it is combined with Ivacaftor.
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Ivacaftor.
PyrazinamideThe serum concentration of Pyrazinamide can be increased when it is combined with Ivacaftor.
QuazepamThe serum concentration of Quazepam can be increased when it is combined with Ivacaftor.
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Ivacaftor.
QuinacrineThe serum concentration of Quinacrine can be increased when it is combined with Ivacaftor.
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Ivacaftor.
QuinineThe serum concentration of Quinine can be increased when it is combined with Ivacaftor.
RabeprazoleThe serum concentration of Rabeprazole can be increased when it is combined with Ivacaftor.
RaloxifeneThe serum concentration of Raloxifene can be increased when it is combined with Ivacaftor.
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Ivacaftor.
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Ivacaftor.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Ivacaftor.
RanolazineThe metabolism of Ivacaftor can be decreased when combined with Ranolazine.
ReboxetineThe serum concentration of Reboxetine can be increased when it is combined with Ivacaftor.
RegorafenibThe serum concentration of Regorafenib can be increased when it is combined with Ivacaftor.
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Ivacaftor.
ReserpineThe serum concentration of Reserpine can be increased when it is combined with Ivacaftor.
RetapamulinThe serum concentration of Retapamulin can be increased when it is combined with Ivacaftor.
RifabutinThe serum concentration of Rifabutin can be increased when it is combined with Ivacaftor.
RifabutinThe serum concentration of Ivacaftor can be decreased when it is combined with Rifabutin.
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Ivacaftor.
RifampicinThe serum concentration of Ivacaftor can be decreased when it is combined with Rifampicin.
RifapentineThe serum concentration of Ivacaftor can be decreased when it is combined with Rifapentine.
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Ivacaftor.
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Ivacaftor.
RimonabantThe serum concentration of Rimonabant can be increased when it is combined with Ivacaftor.
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Ivacaftor.
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Ivacaftor.
RitonavirThe serum concentration of Ritonavir can be increased when it is combined with Ivacaftor.
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Ivacaftor.
RofecoxibThe serum concentration of Rofecoxib can be increased when it is combined with Ivacaftor.
RolapitantThe serum concentration of Rolapitant can be increased when it is combined with Ivacaftor.
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Ivacaftor.
RopiniroleThe serum concentration of Ropinirole can be increased when it is combined with Ivacaftor.
RopivacaineThe serum concentration of Ropivacaine can be increased when it is combined with Ivacaftor.
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Ivacaftor.
RotigotineThe serum concentration of Rotigotine can be increased when it is combined with Ivacaftor.
RoxithromycinThe serum concentration of Roxithromycin can be increased when it is combined with Ivacaftor.
RuxolitinibThe serum concentration of Ruxolitinib can be increased when it is combined with Ivacaftor.
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Ivacaftor.
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Ivacaftor.
SaquinavirThe serum concentration of Saquinavir can be increased when it is combined with Ivacaftor.
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Ivacaftor.
SelegilineThe serum concentration of Selegiline can be increased when it is combined with Ivacaftor.
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Ivacaftor.
SeratrodastThe serum concentration of Seratrodast can be increased when it is combined with Ivacaftor.
SertindoleThe serum concentration of Sertindole can be increased when it is combined with Ivacaftor.
SertralineThe serum concentration of Sertraline can be increased when it is combined with Ivacaftor.
SevofluraneThe serum concentration of Sevoflurane can be increased when it is combined with Ivacaftor.
SibutramineThe serum concentration of Sibutramine can be increased when it is combined with Ivacaftor.
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Ivacaftor.
SildenafilThe metabolism of Ivacaftor can be decreased when combined with Sildenafil.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Ivacaftor.
SiltuximabThe serum concentration of Ivacaftor can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Ivacaftor.
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Ivacaftor.
SirolimusThe serum concentration of Sirolimus can be increased when it is combined with Ivacaftor.
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Ivacaftor.
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Ivacaftor.
SolifenacinThe serum concentration of Solifenacin can be increased when it is combined with Ivacaftor.
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Ivacaftor.
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Ivacaftor.
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Ivacaftor.
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Ivacaftor.
SpiramycinThe serum concentration of Spiramycin can be increased when it is combined with Ivacaftor.
St. John's WortThe serum concentration of Ivacaftor can be decreased when it is combined with St. John&#39;s Wort.
StiripentolThe serum concentration of Ivacaftor can be increased when it is combined with Stiripentol.
SufentanilThe serum concentration of Sufentanil can be increased when it is combined with Ivacaftor.
SulfadiazineThe serum concentration of Sulfadiazine can be increased when it is combined with Ivacaftor.
SulfamethoxazoleThe serum concentration of Sulfamethoxazole can be increased when it is combined with Ivacaftor.
SulfinpyrazoneThe serum concentration of Sulfinpyrazone can be increased when it is combined with Ivacaftor.
SulfisoxazoleThe metabolism of Ivacaftor can be decreased when combined with Sulfisoxazole.
SunitinibThe serum concentration of Sunitinib can be increased when it is combined with Ivacaftor.
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be increased when it is combined with Ivacaftor.
Synthetic Conjugated Estrogens, BThe serum concentration of Synthetic Conjugated Estrogens, B can be increased when it is combined with Ivacaftor.
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Ivacaftor.
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Ivacaftor.
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Ivacaftor.
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Ivacaftor.
TasosartanThe serum concentration of Tasosartan can be increased when it is combined with Ivacaftor.
Taurochenodeoxycholic acidThe serum concentration of Taurochenodeoxycholic acid can be increased when it is combined with Ivacaftor.
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Ivacaftor.
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Ivacaftor.
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Ivacaftor.
TelithromycinThe serum concentration of Telithromycin can be increased when it is combined with Ivacaftor.
TemazepamThe serum concentration of Temazepam can be increased when it is combined with Ivacaftor.
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Ivacaftor.
TeniposideThe serum concentration of Teniposide can be increased when it is combined with Ivacaftor.
TerbinafineThe serum concentration of Terbinafine can be increased when it is combined with Ivacaftor.
TerfenadineThe serum concentration of Terfenadine can be increased when it is combined with Ivacaftor.
TesmilifeneThe serum concentration of Tesmilifene can be increased when it is combined with Ivacaftor.
TestosteroneThe serum concentration of Testosterone can be increased when it is combined with Ivacaftor.
TetracyclineThe serum concentration of Tetracycline can be increased when it is combined with Ivacaftor.
TheophyllineThe serum concentration of Theophylline can be increased when it is combined with Ivacaftor.
ThiotepaThe serum concentration of Thiotepa can be increased when it is combined with Ivacaftor.
TiagabineThe serum concentration of Tiagabine can be increased when it is combined with Ivacaftor.
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Ivacaftor.
TiclopidineThe serum concentration of Ticlopidine can be increased when it is combined with Ivacaftor.
TiclopidineThe metabolism of Ivacaftor can be decreased when combined with Ticlopidine.
TimololThe serum concentration of Timolol can be increased when it is combined with Ivacaftor.
TinidazoleThe serum concentration of Tinidazole can be increased when it is combined with Ivacaftor.
TiotropiumThe serum concentration of Tiotropium can be increased when it is combined with Ivacaftor.
TipranavirThe serum concentration of Tipranavir can be increased when it is combined with Ivacaftor.
TocilizumabThe serum concentration of Ivacaftor can be decreased when it is combined with Tocilizumab.
TofacitinibThe serum concentration of Tofacitinib can be increased when it is combined with Ivacaftor.
TolterodineThe serum concentration of Tolterodine can be increased when it is combined with Ivacaftor.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Ivacaftor.
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Ivacaftor.
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Ivacaftor.
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Ivacaftor.
TramadolThe serum concentration of Tramadol can be increased when it is combined with Ivacaftor.
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Ivacaftor.
TrazodoneThe serum concentration of Trazodone can be increased when it is combined with Ivacaftor.
TretinoinThe serum concentration of Tretinoin can be increased when it is combined with Ivacaftor.
TriamcinoloneThe serum concentration of Triamcinolone can be increased when it is combined with Ivacaftor.
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Ivacaftor.
TrimethadioneThe serum concentration of Trimethadione can be increased when it is combined with Ivacaftor.
TrimethoprimThe serum concentration of Trimethoprim can be increased when it is combined with Ivacaftor.
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Ivacaftor.
TroglitazoneThe serum concentration of Troglitazone can be increased when it is combined with Ivacaftor.
TroleandomycinThe serum concentration of Troleandomycin can be increased when it is combined with Ivacaftor.
UdenafilThe serum concentration of Udenafil can be increased when it is combined with Ivacaftor.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Ivacaftor.
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Ivacaftor.
ValdecoxibThe serum concentration of Valdecoxib can be increased when it is combined with Ivacaftor.
VandetanibThe serum concentration of Vandetanib can be increased when it is combined with Ivacaftor.
VanoxerineThe serum concentration of Vanoxerine can be increased when it is combined with Ivacaftor.
VardenafilThe serum concentration of Vardenafil can be increased when it is combined with Ivacaftor.
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Ivacaftor.
VemurafenibThe serum concentration of Vemurafenib can be increased when it is combined with Ivacaftor.
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Ivacaftor.
VenlafaxineThe metabolism of Ivacaftor can be decreased when combined with Venlafaxine.
VerapamilThe serum concentration of Verapamil can be increased when it is combined with Ivacaftor.
VerapamilThe metabolism of Ivacaftor can be decreased when combined with Verapamil.
VicrivirocThe serum concentration of Vicriviroc can be increased when it is combined with Ivacaftor.
VilanterolThe serum concentration of Vilanterol can be increased when it is combined with Ivacaftor.
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Ivacaftor.
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Ivacaftor.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Ivacaftor.
VindesineThe serum concentration of Vindesine can be increased when it is combined with Ivacaftor.
VinorelbineThe serum concentration of Vinorelbine can be increased when it is combined with Ivacaftor.
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Ivacaftor.
VoriconazoleThe serum concentration of Voriconazole can be increased when it is combined with Ivacaftor.
VortioxetineThe serum concentration of Vortioxetine can be increased when it is combined with Ivacaftor.
WarfarinThe serum concentration of Warfarin can be increased when it is combined with Ivacaftor.
YohimbineThe serum concentration of Yohimbine can be increased when it is combined with Ivacaftor.
ZafirlukastThe serum concentration of Zafirlukast can be increased when it is combined with Ivacaftor.
ZalcitabineThe serum concentration of Zalcitabine can be increased when it is combined with Ivacaftor.
ZaleplonThe serum concentration of Zaleplon can be increased when it is combined with Ivacaftor.
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Ivacaftor.
ZileutonThe serum concentration of Zileuton can be increased when it is combined with Ivacaftor.
ZiprasidoneThe serum concentration of Ziprasidone can be increased when it is combined with Ivacaftor.
ZiprasidoneThe metabolism of Ivacaftor can be decreased when combined with Ziprasidone.
ZolpidemThe serum concentration of Zolpidem can be increased when it is combined with Ivacaftor.
ZomepiracThe serum concentration of Zomepirac can be increased when it is combined with Ivacaftor.
ZonisamideThe serum concentration of Zonisamide can be increased when it is combined with Ivacaftor.
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Ivacaftor.
Food Interactions
  • Exposure increases 2- to 4- fold when given with a high fat meal. It is recommended that ivacaftor be given this way.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
potentiator
General Function:
Pdz domain binding
Specific Function:
Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
Gene Name:
CFTR
Uniprot ID:
P13569
Molecular Weight:
168139.895 Da
References
  1. Yu H, Burton B, Huang CJ, Worley J, Cao D, Johnson JP Jr, Urrutia A, Joubran J, Seepersaud S, Sussky K, Hoffman BJ, Van Goor F: Ivacaftor potentiation of multiple CFTR channels with gating mutations. J Cyst Fibros. 2012 May;11(3):237-45. doi: 10.1016/j.jcf.2011.12.005. Epub 2012 Jan 30. [PubMed:22293084 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da

Carriers

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Toxic substance binding
Specific Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
Gene Name:
ALB
Uniprot ID:
P02768
Molecular Weight:
69365.94 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Not Available
Specific Function:
Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
Gene Name:
ORM1
Uniprot ID:
P02763
Molecular Weight:
23511.38 Da

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
Comments
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Drug created on February 24, 2012 11:15 / Updated on September 29, 2016 02:35