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Identification
NameNetupitant
Accession NumberDB09048
TypeSmall Molecule
GroupsApproved
DescriptionNetupitant is an antiemitic drug approved by the FDA in October 2014 for use in combination with palonosetron for the prevention of acute and delayed vomiting and nausea associated with cancer chemotherapy including highly emetogenic chemotherapy. Netupitant is a neurokinin 1 receptor antagonist. The combination drug is marketed by Eisai Inc. and Helsinn Therapeutics (U.S.) Inc. under the brand Akynzeo®.
Structure
Thumb
Synonyms
2-[3,5-Bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinyl]propanamide
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixtures
NameLabellerIngredients
AkynzeoEisai Inc.
SaltsNot Available
Categories
UNII7732P08TIR
CAS number290297-26-6
WeightAverage: 578.603
Monoisotopic: 578.248030644
Chemical FormulaC30H32F6N4O
InChI KeyWAXQNWCZJDTGBU-UHFFFAOYSA-N
InChI
InChI=1S/C30H32F6N4O/c1-19-8-6-7-9-23(19)24-17-26(40-12-10-38(4)11-13-40)37-18-25(24)39(5)27(41)28(2,3)20-14-21(29(31,32)33)16-22(15-20)30(34,35)36/h6-9,14-18H,10-13H2,1-5H3
IUPAC Name
2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide
SMILES
CN(C(=O)C(C)(C)C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)C1=CN=C(C=C1C1=CC=CC=C1C)N1CCN(C)CC1
Taxonomy
ClassificationNot classified
Pharmacology
IndicationNetupitant is an antiemitic drug approved by the FDA in October 2014 for use in combination with palonosetron for the prevention of acute and delayed vomiting and nausea associated with cancer chemotherapy including highly emetogenic chemotherapy.
PharmacodynamicsNot Available
Mechanism of actionDelayed emesis (vomiting) has been largely associated with the activation of tachykinin family neurokinin 1 (NK1) receptors (broadly distributed in the central and peripheral nervous systems) by substance P. As shown in in vitro and in vivo studies, netupitant inhibits substance P mediated responses.
Related Articles
AbsorptionUpon oral administration of a single dose of netupitant, netupitant started to be measurable in plasma between 15 minutes and 3 hours after dosing. Plasma concentrations reached Cmax in approximately 5 hours. There was a greater than dose-proportional increase in the systemic exposure with the dose increase from 10 mg to 300 mg and a dose-proportional increase in systemic exposure with a dose increase from 300 mg to 450 mg.
Volume of distribution

In cancer patients, Vz/F: 1982 ± 906 L (mean ± SD).

Protein binding> 99.5% at drug concentrations ranging from 10-1300 ng/mL.
Metabolism

Once absorbed, netupitant is extensively metabolized to form three major metabolites: desmethyl derivative, M1; N-oxide derivative, M2; and OH-methyl derivative, M3. Metabolism is mediated primarily by CYP3A4 and to a lesser extent by CYP2C9 and CYP2D6. Metabolites M1, M2 and M3 were shown to bind to the substance P/neurokinin 1 (NK1) receptor.

SubstrateEnzymesProduct
Netupitant
Desmethyl NetupitantDetails
Netupitant
N-oxide NetupitantDetails
Route of eliminationPrimarily fecal.
Half life96 hours with CV% of 61.
Clearance

estimated systemic clearance of 20.3 ± 9.2 L/h (mean ± SD).

ToxicityDaily oral administration of netupitant in rats at doses up to 30 mg/kg (1.9 times the human AUC in male rats and 3.7 times the human AUC in female rats at the recommended human dose) had no effects on fertility or reproductive performance.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal AbsorptionNot AvailableNot Available
Blood Brain BarrierNot AvailableNot Available
Caco-2 permeableNot AvailableNot Available
P-glycoprotein substrateNot AvailableNot Available
P-glycoprotein inhibitor INot AvailableNot Available
P-glycoprotein inhibitor IINot AvailableNot Available
Renal organic cation transporterNot AvailableNot Available
CYP450 2C9 substrateNot AvailableNot Available
CYP450 2D6 substrateNot AvailableNot Available
CYP450 3A4 substrateNot AvailableNot Available
CYP450 1A2 substrateNot AvailableNot Available
CYP450 2C9 inhibitorNot AvailableNot Available
CYP450 2D6 inhibitorNot AvailableNot Available
CYP450 2C19 inhibitorNot AvailableNot Available
CYP450 3A4 inhibitorNot AvailableNot Available
CYP450 inhibitory promiscuityNot AvailableNot Available
Ames testNot AvailableNot Available
CarcinogenicityNot AvailableNot Available
BiodegradationNot AvailableNot Available
Rat acute toxicityNot AvailableNot applicable
hERG inhibition (predictor I)Not AvailableNot Available
hERG inhibition (predictor II)Not AvailableNot Available
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
Capsuleoral
PricesNot Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6297375 No2000-02-222020-02-22Us
US8623826 No2010-11-182030-11-18Us
US8951969 No2010-11-182030-11-18Us
US9186357 No2010-11-182030-11-18Us
Properties
StateSolid
Experimental PropertiesNot Available
Predicted Properties
PropertyValueSource
Water Solubility0.00285 mg/mLALOGPS
logP5.48ALOGPS
logP7.26ChemAxon
logS-5.3ALOGPS
pKa (Strongest Basic)7.6ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area39.68 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity148.59 m3·mol-1ChemAxon
Polarizability55.88 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis ReferenceNot Available
General References
  1. Darmani NA, Zhong W, Chebolu S, Mercadante F: Differential and additive suppressive effects of 5-HT3 (palonosetron)- and NK1 (netupitant)-receptor antagonists on cisplatin-induced vomiting and ERK1/2, PKA and PKC activation. Pharmacol Biochem Behav. 2015 Apr;131:104-11. doi: 10.1016/j.pbb.2015.02.010. Epub 2015 Feb 14. [PubMed:25687374 ]
External Links
ATC CodesNot Available
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelDownload (273 KB)
MSDSNot Available
Interactions
Drug Interactions
Drug
AbirateroneThe serum concentration of Abiraterone can be increased when it is combined with Netupitant.
AbirateroneThe metabolism of Netupitant can be decreased when combined with Abiraterone.
AcenocoumarolThe serum concentration of Acenocoumarol can be increased when it is combined with Netupitant.
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Netupitant.
AdinazolamThe serum concentration of Adinazolam can be increased when it is combined with Netupitant.
AlbendazoleThe serum concentration of Albendazole can be increased when it is combined with Netupitant.
AlclometasoneThe serum concentration of Alclometasone can be increased when it is combined with Netupitant.
AlfentanilThe serum concentration of Alfentanil can be increased when it is combined with Netupitant.
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Netupitant.
AliskirenThe serum concentration of Aliskiren can be increased when it is combined with Netupitant.
AllylestrenolThe serum concentration of Allylestrenol can be increased when it is combined with Netupitant.
AlmotriptanThe serum concentration of Almotriptan can be increased when it is combined with Netupitant.
AlogliptinThe serum concentration of Alogliptin can be increased when it is combined with Netupitant.
AlosetronThe serum concentration of Alosetron can be increased when it is combined with Netupitant.
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Netupitant.
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Netupitant.
AmbroxolThe serum concentration of Ambroxol can be increased when it is combined with Netupitant.
AminophenazoneThe serum concentration of Aminophenazone can be increased when it is combined with Netupitant.
AminophyllineThe serum concentration of Aminophylline can be increased when it is combined with Netupitant.
AmiodaroneThe serum concentration of Amiodarone can be increased when it is combined with Netupitant.
AmiodaroneThe metabolism of Netupitant can be decreased when combined with Amiodarone.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Netupitant.
AmlodipineThe serum concentration of Amlodipine can be increased when it is combined with Netupitant.
AmprenavirThe serum concentration of Amprenavir can be increased when it is combined with Netupitant.
AntipyrineThe serum concentration of Antipyrine can be increased when it is combined with Netupitant.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Netupitant.
ApremilastThe serum concentration of Apremilast can be increased when it is combined with Netupitant.
AprepitantThe serum concentration of Aprepitant can be increased when it is combined with Netupitant.
AprepitantThe metabolism of Netupitant can be increased when combined with Aprepitant.
ArgatrobanThe serum concentration of Argatroban can be increased when it is combined with Netupitant.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Netupitant.
ArtemetherThe serum concentration of Artemether can be increased when it is combined with Netupitant.
ArtemetherThe metabolism of Netupitant can be decreased when combined with Artemether.
AsenapineThe serum concentration of Asenapine can be increased when it is combined with Netupitant.
AstemizoleThe serum concentration of Astemizole can be increased when it is combined with Netupitant.
AtazanavirThe serum concentration of Atazanavir can be increased when it is combined with Netupitant.
AtomoxetineThe metabolism of Netupitant can be decreased when combined with Atomoxetine.
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Netupitant.
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Netupitant.
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Netupitant.
AzelastineThe serum concentration of Azelastine can be increased when it is combined with Netupitant.
AzithromycinThe serum concentration of Azithromycin can be increased when it is combined with Netupitant.
BanoxantroneThe serum concentration of Banoxantrone can be increased when it is combined with Netupitant.
BedaquilineThe serum concentration of Bedaquiline can be increased when it is combined with Netupitant.
BenzphetamineThe serum concentration of Benzphetamine can be increased when it is combined with Netupitant.
Benzyl alcoholThe serum concentration of Benzyl alcohol can be increased when it is combined with Netupitant.
BetaxololThe metabolism of Netupitant can be decreased when combined with Betaxolol.
BexaroteneThe serum concentration of Bexarotene can be increased when it is combined with Netupitant.
BezafibrateThe serum concentration of Bezafibrate can be increased when it is combined with Netupitant.
BicalutamideThe serum concentration of Bicalutamide can be increased when it is combined with Netupitant.
BisoprololThe serum concentration of Bisoprolol can be increased when it is combined with Netupitant.
BoceprevirThe serum concentration of Boceprevir can be increased when it is combined with Netupitant.
BortezomibThe serum concentration of Bortezomib can be increased when it is combined with Netupitant.
BosentanThe serum concentration of Bosentan can be increased when it is combined with Netupitant.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Netupitant.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Netupitant.
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Netupitant.
BrinzolamideThe serum concentration of Brinzolamide can be increased when it is combined with Netupitant.
BromazepamThe serum concentration of Bromazepam can be increased when it is combined with Netupitant.
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Netupitant.
BrompheniramineThe serum concentration of Brompheniramine can be increased when it is combined with Netupitant.
BudesonideThe metabolism of Budesonide can be decreased when combined with Netupitant.
BupivacaineThe serum concentration of Bupivacaine can be increased when it is combined with Netupitant.
BuprenorphineThe serum concentration of Buprenorphine can be increased when it is combined with Netupitant.
BupropionThe serum concentration of Bupropion can be increased when it is combined with Netupitant.
BupropionThe metabolism of Netupitant can be decreased when combined with Bupropion.
BuspironeThe serum concentration of Buspirone can be increased when it is combined with Netupitant.
BusulfanThe serum concentration of Busulfan can be increased when it is combined with Netupitant.
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Netupitant.
CabergolineThe serum concentration of Cabergoline can be increased when it is combined with Netupitant.
CabozantinibThe serum concentration of Cabozantinib can be increased when it is combined with Netupitant.
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Netupitant.
CalcitriolThe serum concentration of Calcitriol can be increased when it is combined with Netupitant.
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Netupitant.
CapecitabineThe metabolism of Netupitant can be decreased when combined with Capecitabine.
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Netupitant.
CarbamazepineThe serum concentration of Netupitant can be decreased when it is combined with Carbamazepine.
CarbinoxamineThe serum concentration of Carbinoxamine can be increased when it is combined with Netupitant.
CariprazineThe serum concentration of Cariprazine can be increased when it is combined with Netupitant.
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Netupitant.
CelecoxibThe serum concentration of Celecoxib can be increased when it is combined with Netupitant.
CelecoxibThe metabolism of Netupitant can be decreased when combined with Celecoxib.
CeliprololThe serum concentration of Celiprolol can be increased when it is combined with Netupitant.
CephalexinThe serum concentration of Cephalexin can be increased when it is combined with Netupitant.
CeritinibThe serum concentration of Netupitant can be increased when it is combined with Ceritinib.
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Netupitant.
CevimelineThe serum concentration of Cevimeline can be increased when it is combined with Netupitant.
Chenodeoxycholic acidThe serum concentration of Chenodeoxycholic acid can be increased when it is combined with Netupitant.
ChlordiazepoxideThe serum concentration of Chlordiazepoxide can be increased when it is combined with Netupitant.
ChloroquineThe serum concentration of Chloroquine can be increased when it is combined with Netupitant.
ChloroquineThe metabolism of Netupitant can be decreased when combined with Chloroquine.
ChlorphenamineThe serum concentration of Chlorphenamine can be increased when it is combined with Netupitant.
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Netupitant.
ChlorpromazineThe metabolism of Netupitant can be decreased when combined with Chlorpromazine.
ChlorzoxazoneThe serum concentration of Chlorzoxazone can be increased when it is combined with Netupitant.
CholecalciferolThe serum concentration of Cholecalciferol can be increased when it is combined with Netupitant.
CholecalciferolThe metabolism of Netupitant can be decreased when combined with Cholecalciferol.
CiclesonideThe serum concentration of Ciclesonide can be increased when it is combined with Netupitant.
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Netupitant.
CimetidineThe metabolism of Netupitant can be decreased when combined with Cimetidine.
CinacalcetThe serum concentration of Cinacalcet can be increased when it is combined with Netupitant.
CinacalcetThe metabolism of Netupitant can be decreased when combined with Cinacalcet.
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Netupitant.
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Netupitant.
CitalopramThe metabolism of Netupitant can be decreased when combined with Citalopram.
ClarithromycinThe serum concentration of Clarithromycin can be increased when it is combined with Netupitant.
ClemastineThe metabolism of Netupitant can be decreased when combined with Clemastine.
ClindamycinThe serum concentration of Clindamycin can be increased when it is combined with Netupitant.
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Netupitant.
ClobazamThe metabolism of Netupitant can be decreased when combined with Clobazam.
ClofazimineThe serum concentration of Clofazimine can be increased when it is combined with Netupitant.
ClofibrateThe serum concentration of Clofibrate can be increased when it is combined with Netupitant.
clomethiazoleThe serum concentration of clomethiazole can be increased when it is combined with Netupitant.
ClomipramineThe serum concentration of Clomipramine can be increased when it is combined with Netupitant.
ClomipramineThe metabolism of Netupitant can be decreased when combined with Clomipramine.
ClonazepamThe serum concentration of Clonazepam can be increased when it is combined with Netupitant.
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Netupitant.
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Netupitant.
ClorazepateThe serum concentration of Clorazepate can be increased when it is combined with Netupitant.
ClotiazepamThe serum concentration of Clotiazepam can be increased when it is combined with Netupitant.
ClotrimazoleThe metabolism of Netupitant can be decreased when combined with Clotrimazole.
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Netupitant.
ClozapineThe metabolism of Netupitant can be decreased when combined with Clozapine.
CobicistatThe serum concentration of Netupitant can be increased when it is combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Netupitant.
CocaineThe serum concentration of Cocaine can be increased when it is combined with Netupitant.
CocaineThe metabolism of Netupitant can be decreased when combined with Cocaine.
CodeineThe serum concentration of Codeine can be increased when it is combined with Netupitant.
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Netupitant.
ConivaptanThe serum concentration of Conivaptan can be increased when it is combined with Netupitant.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Netupitant.
Cortisone acetateThe serum concentration of Cortisone acetate can be increased when it is combined with Netupitant.
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Netupitant.
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be increased when it is combined with Netupitant.
CyclophosphamideThe serum concentration of Cyclophosphamide can be increased when it is combined with Netupitant.
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Netupitant.
CyclosporineThe metabolism of Netupitant can be decreased when combined with Cyclosporine.
CytarabineThe serum concentration of Cytarabine can be increased when it is combined with Netupitant.
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Netupitant.
DabrafenibThe serum concentration of Netupitant can be decreased when it is combined with Dabrafenib.
DaclatasvirThe serum concentration of Daclatasvir can be increased when it is combined with Netupitant.
DantroleneThe serum concentration of Dantrolene can be increased when it is combined with Netupitant.
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Netupitant.
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Netupitant.
DapsoneThe serum concentration of Dapsone can be increased when it is combined with Netupitant.
DarifenacinThe serum concentration of Darifenacin can be increased when it is combined with Netupitant.
DarifenacinThe metabolism of Netupitant can be decreased when combined with Darifenacin.
DarunavirThe serum concentration of Darunavir can be increased when it is combined with Netupitant.
DasabuvirThe serum concentration of Dasabuvir can be increased when it is combined with Netupitant.
DasatinibThe serum concentration of Dasatinib can be increased when it is combined with Netupitant.
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Netupitant.
DehydroepiandrosteroneThe serum concentration of Dehydroepiandrosterone can be increased when it is combined with Netupitant.
DelavirdineThe serum concentration of Delavirdine can be increased when it is combined with Netupitant.
DelavirdineThe metabolism of Netupitant can be decreased when combined with Delavirdine.
DesipramineThe metabolism of Netupitant can be decreased when combined with Desipramine.
DesvenlafaxineThe serum concentration of Desvenlafaxine can be increased when it is combined with Netupitant.
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Netupitant.
DextromethorphanThe serum concentration of Dextromethorphan can be increased when it is combined with Netupitant.
DextropropoxypheneThe serum concentration of Dextropropoxyphene can be increased when it is combined with Netupitant.
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Netupitant.
DiclofenacThe serum concentration of Diclofenac can be increased when it is combined with Netupitant.
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Netupitant.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Netupitant.
DihydrocodeineThe serum concentration of Dihydrocodeine can be increased when it is combined with Netupitant.
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Netupitant.
DiltiazemThe serum concentration of Diltiazem can be increased when it is combined with Netupitant.
DiphenhydramineThe metabolism of Netupitant can be decreased when combined with Diphenhydramine.
DisopyramideThe serum concentration of Disopyramide can be increased when it is combined with Netupitant.
DisulfiramThe serum concentration of Disulfiram can be increased when it is combined with Netupitant.
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Netupitant.
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Netupitant.
DolasetronThe serum concentration of Dolasetron can be increased when it is combined with Netupitant.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Netupitant.
DonepezilThe serum concentration of Donepezil can be increased when it is combined with Netupitant.
DorzolamideThe serum concentration of Dorzolamide can be increased when it is combined with Netupitant.
DoxepinThe serum concentration of Doxepin can be increased when it is combined with Netupitant.
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Netupitant.
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Netupitant.
DronedaroneThe serum concentration of Dronedarone can be increased when it is combined with Netupitant.
DronedaroneThe metabolism of Netupitant can be decreased when combined with Dronedarone.
DuloxetineThe metabolism of Netupitant can be decreased when combined with Duloxetine.
DutasterideThe serum concentration of Dutasteride can be increased when it is combined with Netupitant.
EfavirenzThe serum concentration of Efavirenz can be increased when it is combined with Netupitant.
EfavirenzThe metabolism of Netupitant can be decreased when combined with Efavirenz.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Netupitant.
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Netupitant.
EliglustatThe metabolism of Netupitant can be decreased when combined with Eliglustat.
ElvitegravirThe serum concentration of Elvitegravir can be increased when it is combined with Netupitant.
EnalaprilThe serum concentration of Enalapril can be increased when it is combined with Netupitant.
EnzalutamideThe serum concentration of Enzalutamide can be increased when it is combined with Netupitant.
EnzalutamideThe serum concentration of Netupitant can be decreased when it is combined with Enzalutamide.
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Netupitant.
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Netupitant.
ErgocalciferolThe serum concentration of Ergocalciferol can be increased when it is combined with Netupitant.
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Netupitant.
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Netupitant.
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Netupitant.
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Netupitant.
ErythromycinThe serum concentration of Erythromycin can be increased when it is combined with Netupitant.
EscitalopramThe serum concentration of Escitalopram can be increased when it is combined with Netupitant.
EsomeprazoleThe serum concentration of Esomeprazole can be increased when it is combined with Netupitant.
EstazolamThe serum concentration of Estazolam can be increased when it is combined with Netupitant.
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Netupitant.
Estradiol valerate/DienogestThe serum concentration of Estradiol valerate/Dienogest can be increased when it is combined with Netupitant.
EstramustineThe serum concentration of Estramustine can be increased when it is combined with Netupitant.
EstroneThe serum concentration of Estrone can be increased when it is combined with Netupitant.
Estrone sulfateThe serum concentration of Estrone sulfate can be increased when it is combined with Netupitant.
EszopicloneThe serum concentration of Eszopiclone can be increased when it is combined with Netupitant.
EthanolThe serum concentration of Ethanol can be increased when it is combined with Netupitant.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Netupitant.
EthosuximideThe serum concentration of Ethosuximide can be increased when it is combined with Netupitant.
EthylmorphineThe serum concentration of Ethylmorphine can be increased when it is combined with Netupitant.
EtonogestrelThe serum concentration of Etonogestrel can be increased when it is combined with Netupitant.
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Netupitant.
EtoricoxibThe serum concentration of Etoricoxib can be increased when it is combined with Netupitant.
EtravirineThe serum concentration of Etravirine can be increased when it is combined with Netupitant.
EtravirineThe metabolism of Netupitant can be decreased when combined with Etravirine.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Netupitant.
ExemestaneThe serum concentration of Exemestane can be increased when it is combined with Netupitant.
FamciclovirThe serum concentration of Famciclovir can be increased when it is combined with Netupitant.
FelbamateThe serum concentration of Felbamate can be increased when it is combined with Netupitant.
FelodipineThe serum concentration of Felodipine can be increased when it is combined with Netupitant.
FenofibrateThe serum concentration of Fenofibrate can be increased when it is combined with Netupitant.
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Netupitant.
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Netupitant.
FinasterideThe serum concentration of Finasteride can be increased when it is combined with Netupitant.
FingolimodThe serum concentration of Fingolimod can be increased when it is combined with Netupitant.
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Netupitant.
FloxuridineThe metabolism of Netupitant can be decreased when combined with Floxuridine.
FluconazoleThe metabolism of Netupitant can be decreased when combined with Fluconazole.
FlunisolideThe serum concentration of Flunisolide can be increased when it is combined with Netupitant.
FlunitrazepamThe serum concentration of Flunitrazepam can be increased when it is combined with Netupitant.
FluorometholoneThe serum concentration of Fluorometholone can be increased when it is combined with Netupitant.
FluorouracilThe metabolism of Netupitant can be decreased when combined with Fluorouracil.
FluoxetineThe serum concentration of Fluoxetine can be increased when it is combined with Netupitant.
FluoxetineThe metabolism of Netupitant can be decreased when combined with Fluoxetine.
FlurazepamThe serum concentration of Flurazepam can be increased when it is combined with Netupitant.
FlutamideThe serum concentration of Flutamide can be increased when it is combined with Netupitant.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Netupitant.
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be increased when it is combined with Netupitant.
FluvastatinThe serum concentration of Fluvastatin can be increased when it is combined with Netupitant.
FluvastatinThe metabolism of Netupitant can be decreased when combined with Fluvastatin.
FluvoxamineThe metabolism of Netupitant can be decreased when combined with Fluvoxamine.
FosamprenavirThe serum concentration of Fosamprenavir can be increased when it is combined with Netupitant.
FosphenytoinThe serum concentration of Netupitant can be decreased when it is combined with Fosphenytoin.
FulvestrantThe serum concentration of Fulvestrant can be increased when it is combined with Netupitant.
GalantamineThe serum concentration of Galantamine can be increased when it is combined with Netupitant.
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Netupitant.
GemfibrozilThe serum concentration of Gemfibrozil can be increased when it is combined with Netupitant.
GemfibrozilThe metabolism of Netupitant can be decreased when combined with Gemfibrozil.
GlipizideThe serum concentration of Glipizide can be increased when it is combined with Netupitant.
GlyburideThe serum concentration of Glyburide can be increased when it is combined with Netupitant.
GranisetronThe serum concentration of Granisetron can be increased when it is combined with Netupitant.
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Netupitant.
GuanfacineThe serum concentration of Guanfacine can be increased when it is combined with Netupitant.
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Netupitant.
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Netupitant.
HaloperidolThe metabolism of Netupitant can be decreased when combined with Haloperidol.
HalothaneThe serum concentration of Halothane can be increased when it is combined with Netupitant.
HexobarbitalThe serum concentration of Hexobarbital can be increased when it is combined with Netupitant.
Histamine PhosphateThe serum concentration of Histamine Phosphate can be increased when it is combined with Netupitant.
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Netupitant.
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Netupitant.
HydromorphoneThe serum concentration of Hydromorphone can be increased when it is combined with Netupitant.
Hydroxyprogesterone caproateThe serum concentration of Hydroxyprogesterone caproate can be increased when it is combined with Netupitant.
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Netupitant.
IfosfamideThe serum concentration of Ifosfamide can be increased when it is combined with Netupitant.
IloperidoneThe serum concentration of Iloperidone can be increased when it is combined with Netupitant.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Netupitant.
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Netupitant.
ImipramineThe metabolism of Netupitant can be decreased when combined with Imipramine.
ImiquimodThe serum concentration of Imiquimod can be increased when it is combined with Netupitant.
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Netupitant.
IndapamideThe serum concentration of Indapamide can be increased when it is combined with Netupitant.
IndinavirThe serum concentration of Indinavir can be increased when it is combined with Netupitant.
IndinavirThe metabolism of Netupitant can be decreased when combined with Indinavir.
Ipratropium bromideThe serum concentration of Ipratropium bromide can be increased when it is combined with Netupitant.
IrbesartanThe metabolism of Netupitant can be decreased when combined with Irbesartan.
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Netupitant.
IsavuconazoniumThe serum concentration of Isavuconazonium can be increased when it is combined with Netupitant.
IsoniazidThe metabolism of Netupitant can be decreased when combined with Isoniazid.
Isosorbide DinitrateThe serum concentration of Isosorbide Dinitrate can be increased when it is combined with Netupitant.
Isosorbide MononitrateThe serum concentration of Isosorbide Mononitrate can be increased when it is combined with Netupitant.
IsradipineThe serum concentration of Isradipine can be increased when it is combined with Netupitant.
ItraconazoleThe serum concentration of Itraconazole can be increased when it is combined with Netupitant.
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Netupitant.
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Netupitant.
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Netupitant.
IxabepiloneThe serum concentration of Ixabepilone can be increased when it is combined with Netupitant.
IxazomibThe serum concentration of Ixazomib can be increased when it is combined with Netupitant.
KetamineThe serum concentration of Ketamine can be increased when it is combined with Netupitant.
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Netupitant.
KetobemidoneThe serum concentration of Ketobemidone can be increased when it is combined with Netupitant.
KetoconazoleThe serum concentration of Ketoconazole can be increased when it is combined with Netupitant.
KetoconazoleThe metabolism of Netupitant can be decreased when combined with Ketoconazole.
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Netupitant.
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Netupitant.
LaquinimodThe serum concentration of Laquinimod can be increased when it is combined with Netupitant.
LeflunomideThe metabolism of Netupitant can be decreased when combined with Leflunomide.
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Netupitant.
LercanidipineThe serum concentration of Lercanidipine can be increased when it is combined with Netupitant.
LetrozoleThe serum concentration of Letrozole can be increased when it is combined with Netupitant.
LevobupivacaineThe serum concentration of Levobupivacaine can be increased when it is combined with Netupitant.
LevocetirizineThe serum concentration of Levocetirizine can be increased when it is combined with Netupitant.
Levomethadyl AcetateThe serum concentration of Levomethadyl Acetate can be increased when it is combined with Netupitant.
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Netupitant.
LevonorgestrelThe serum concentration of Levonorgestrel can be increased when it is combined with Netupitant.
LevothyroxineThe serum concentration of Levothyroxine can be increased when it is combined with Netupitant.
LidocaineThe serum concentration of Lidocaine can be increased when it is combined with Netupitant.
LisurideThe serum concentration of Lisuride can be increased when it is combined with Netupitant.
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Netupitant.
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Netupitant.
LopinavirThe serum concentration of Lopinavir can be increased when it is combined with Netupitant.
LopinavirThe metabolism of Netupitant can be decreased when combined with Lopinavir.
LoratadineThe serum concentration of Loratadine can be increased when it is combined with Netupitant.
LorcaserinThe serum concentration of Lorcaserin can be increased when it is combined with Netupitant.
LorcaserinThe metabolism of Netupitant can be decreased when combined with Lorcaserin.
LosartanThe serum concentration of Losartan can be increased when it is combined with Netupitant.
LosartanThe metabolism of Netupitant can be decreased when combined with Losartan.
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Netupitant.
LovastatinThe metabolism of Netupitant can be decreased when combined with Lovastatin.
LumacaftorThe serum concentration of Netupitant can be decreased when it is combined with Lumacaftor.
LumefantrineThe serum concentration of Lumefantrine can be increased when it is combined with Netupitant.
LumefantrineThe metabolism of Netupitant can be decreased when combined with Lumefantrine.
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Netupitant.
MacitentanThe serum concentration of Macitentan can be increased when it is combined with Netupitant.
MaravirocThe serum concentration of Maraviroc can be increased when it is combined with Netupitant.
MebendazoleThe serum concentration of Mebendazole can be increased when it is combined with Netupitant.
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be increased when it is combined with Netupitant.
MefloquineThe serum concentration of Mefloquine can be increased when it is combined with Netupitant.
MeloxicamThe serum concentration of Meloxicam can be increased when it is combined with Netupitant.
MethadoneThe serum concentration of Methadone can be increased when it is combined with Netupitant.
MethadoneThe metabolism of Netupitant can be decreased when combined with Methadone.
MethaqualoneThe serum concentration of Methaqualone can be increased when it is combined with Netupitant.
MethotrimeprazineThe metabolism of Netupitant can be decreased when combined with Methotrimeprazine.
MethoxsalenThe serum concentration of Methoxsalen can be increased when it is combined with Netupitant.
MethoxyfluraneThe serum concentration of Methoxyflurane can be increased when it is combined with Netupitant.
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Netupitant.
MethyltestosteroneThe serum concentration of Methyltestosterone can be increased when it is combined with Netupitant.
MetoprololThe metabolism of Netupitant can be decreased when combined with Metoprolol.
MetronidazoleThe serum concentration of Metronidazole can be increased when it is combined with Netupitant.
MexiletineThe serum concentration of Mexiletine can be increased when it is combined with Netupitant.
MianserinThe serum concentration of Mianserin can be increased when it is combined with Netupitant.
MibefradilThe serum concentration of Mibefradil can be increased when it is combined with Netupitant.
MiconazoleThe serum concentration of Miconazole can be increased when it is combined with Netupitant.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Netupitant.
MifepristoneThe serum concentration of Mifepristone can be increased when it is combined with Netupitant.
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Netupitant.
MirabegronThe metabolism of Netupitant can be decreased when combined with Mirabegron.
MirtazapineThe serum concentration of Mirtazapine can be increased when it is combined with Netupitant.
MitotaneThe serum concentration of Netupitant can be decreased when it is combined with Mitotane.
ModafinilThe serum concentration of Modafinil can be increased when it is combined with Netupitant.
MontelukastThe serum concentration of Montelukast can be increased when it is combined with Netupitant.
MorphineThe serum concentration of Morphine can be increased when it is combined with Netupitant.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Netupitant.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Netupitant.
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Netupitant.
NateglinideThe serum concentration of Nateglinide can be increased when it is combined with Netupitant.
NefazodoneThe serum concentration of Nefazodone can be increased when it is combined with Netupitant.
NelfinavirThe serum concentration of Nelfinavir can be increased when it is combined with Netupitant.
NevirapineThe serum concentration of Nevirapine can be increased when it is combined with Netupitant.
NevirapineThe serum concentration of Netupitant can be decreased when it is combined with Nevirapine.
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Netupitant.
NicardipineThe metabolism of Netupitant can be decreased when combined with Nicardipine.
NicotineThe serum concentration of Nicotine can be increased when it is combined with Netupitant.
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Netupitant.
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Netupitant.
NilotinibThe metabolism of Netupitant can be decreased when combined with Nilotinib.
NilvadipineThe serum concentration of Nilvadipine can be increased when it is combined with Netupitant.
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Netupitant.
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Netupitant.
NitrazepamThe serum concentration of Nitrazepam can be increased when it is combined with Netupitant.
NitrendipineThe serum concentration of Nitrendipine can be increased when it is combined with Netupitant.
NorethisteroneThe serum concentration of Norethisterone can be increased when it is combined with Netupitant.
NorgestrelThe serum concentration of Norgestrel can be increased when it is combined with Netupitant.
NortriptylineThe serum concentration of Nortriptyline can be increased when it is combined with Netupitant.
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Netupitant.
OlopatadineThe serum concentration of Olopatadine can be increased when it is combined with Netupitant.
OmeprazoleThe serum concentration of Omeprazole can be increased when it is combined with Netupitant.
OmeprazoleThe metabolism of Netupitant can be decreased when combined with Omeprazole.
OndansetronThe serum concentration of Ondansetron can be increased when it is combined with Netupitant.
OrphenadrineThe serum concentration of Orphenadrine can be increased when it is combined with Netupitant.
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Netupitant.
OxazepamThe serum concentration of Oxazepam can be increased when it is combined with Netupitant.
OxybutyninThe serum concentration of Oxybutynin can be increased when it is combined with Netupitant.
OxycodoneThe serum concentration of Oxycodone can be increased when it is combined with Netupitant.
OxymorphoneThe serum concentration of Oxymorphone can be increased when it is combined with Netupitant.
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Netupitant.
PalbociclibThe serum concentration of Palbociclib can be increased when it is combined with Netupitant.
PalonosetronThe serum concentration of Palonosetron can be increased when it is combined with Netupitant.
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Netupitant.
PanobinostatThe metabolism of Netupitant can be decreased when combined with Panobinostat.
PantoprazoleThe serum concentration of Pantoprazole can be increased when it is combined with Netupitant.
ParamethadioneThe serum concentration of Paramethadione can be increased when it is combined with Netupitant.
ParamethasoneThe serum concentration of Paramethasone can be increased when it is combined with Netupitant.
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Netupitant.
ParicalcitolThe serum concentration of Paricalcitol can be increased when it is combined with Netupitant.
ParitaprevirThe serum concentration of Paritaprevir can be increased when it is combined with Netupitant.
ParoxetineThe metabolism of Netupitant can be decreased when combined with Paroxetine.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Netupitant.
Peginterferon alfa-2bThe serum concentration of Netupitant can be decreased when it is combined with Peginterferon alfa-2b.
PentamidineThe serum concentration of Pentamidine can be increased when it is combined with Netupitant.
PentobarbitalThe serum concentration of Netupitant can be decreased when it is combined with Pentobarbital.
PerampanelThe serum concentration of Perampanel can be increased when it is combined with Netupitant.
PergolideThe serum concentration of Pergolide can be increased when it is combined with Netupitant.
PerhexilineThe serum concentration of Perhexiline can be increased when it is combined with Netupitant.
PermethrinThe serum concentration of Permethrin can be increased when it is combined with Netupitant.
PerphenazineThe serum concentration of Perphenazine can be increased when it is combined with Netupitant.
PethidineThe serum concentration of Pethidine can be increased when it is combined with Netupitant.
PhenacetinThe serum concentration of Phenacetin can be increased when it is combined with Netupitant.
PhenobarbitalThe serum concentration of Netupitant can be decreased when it is combined with Phenobarbital.
PhenoxybenzamineThe serum concentration of Phenoxybenzamine can be increased when it is combined with Netupitant.
PhenprocoumonThe serum concentration of Phenprocoumon can be increased when it is combined with Netupitant.
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Netupitant.
PhenytoinThe serum concentration of Netupitant can be decreased when it is combined with Phenytoin.
PilocarpineThe serum concentration of Pilocarpine can be increased when it is combined with Netupitant.
PimecrolimusThe serum concentration of Pimecrolimus can be increased when it is combined with Netupitant.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Netupitant.
PinacidilThe serum concentration of Pinacidil can be increased when it is combined with Netupitant.
PioglitazoneThe serum concentration of Pioglitazone can be increased when it is combined with Netupitant.
PipotiazineThe serum concentration of Pipotiazine can be increased when it is combined with Netupitant.
PodofiloxThe serum concentration of Podofilox can be increased when it is combined with Netupitant.
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Netupitant.
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Netupitant.
PosaconazoleThe serum concentration of Posaconazole can be increased when it is combined with Netupitant.
PrasugrelThe serum concentration of Prasugrel can be increased when it is combined with Netupitant.
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Netupitant.
PrazepamThe serum concentration of Prazepam can be increased when it is combined with Netupitant.
PraziquantelThe serum concentration of Praziquantel can be increased when it is combined with Netupitant.
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Netupitant.
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Netupitant.
PrimaquineThe serum concentration of Primaquine can be increased when it is combined with Netupitant.
PrimidoneThe serum concentration of Netupitant can be decreased when it is combined with Primidone.
ProchlorperazineThe serum concentration of Prochlorperazine can be increased when it is combined with Netupitant.
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Netupitant.
ProguanilThe serum concentration of Proguanil can be increased when it is combined with Netupitant.
PromazineThe serum concentration of Promazine can be increased when it is combined with Netupitant.
PromazineThe metabolism of Netupitant can be decreased when combined with Promazine.
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Netupitant.
PropofolThe serum concentration of Propofol can be increased when it is combined with Netupitant.
PropranololThe serum concentration of Propranolol can be increased when it is combined with Netupitant.
PyrazinamideThe serum concentration of Pyrazinamide can be increased when it is combined with Netupitant.
PyrimethamineThe metabolism of Netupitant can be decreased when combined with Pyrimethamine.
QuazepamThe serum concentration of Quazepam can be increased when it is combined with Netupitant.
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Netupitant.
QuinacrineThe serum concentration of Quinacrine can be increased when it is combined with Netupitant.
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Netupitant.
QuinidineThe metabolism of Netupitant can be decreased when combined with Quinidine.
QuinineThe serum concentration of Quinine can be increased when it is combined with Netupitant.
QuinineThe metabolism of Netupitant can be decreased when combined with Quinine.
RabeprazoleThe serum concentration of Rabeprazole can be increased when it is combined with Netupitant.
RaloxifeneThe serum concentration of Raloxifene can be increased when it is combined with Netupitant.
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Netupitant.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Netupitant.
RanolazineThe metabolism of Netupitant can be decreased when combined with Ranolazine.
ReboxetineThe serum concentration of Reboxetine can be increased when it is combined with Netupitant.
RegorafenibThe serum concentration of Regorafenib can be increased when it is combined with Netupitant.
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Netupitant.
RetapamulinThe serum concentration of Retapamulin can be increased when it is combined with Netupitant.
RifabutinThe serum concentration of Rifabutin can be increased when it is combined with Netupitant.
RifabutinThe serum concentration of Netupitant can be decreased when it is combined with Rifabutin.
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Netupitant.
RifampicinThe serum concentration of Netupitant can be decreased when it is combined with Rifampicin.
RifapentineThe serum concentration of Netupitant can be decreased when it is combined with Rifapentine.
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Netupitant.
RimonabantThe serum concentration of Rimonabant can be increased when it is combined with Netupitant.
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Netupitant.
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Netupitant.
RitonavirThe serum concentration of Ritonavir can be increased when it is combined with Netupitant.
RitonavirThe metabolism of Netupitant can be decreased when combined with Ritonavir.
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Netupitant.
RofecoxibThe serum concentration of Rofecoxib can be increased when it is combined with Netupitant.
RolapitantThe serum concentration of Rolapitant can be increased when it is combined with Netupitant.
RolapitantThe metabolism of Netupitant can be decreased when combined with Rolapitant.
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Netupitant.
RopiniroleThe serum concentration of Ropinirole can be increased when it is combined with Netupitant.
RopiniroleThe metabolism of Netupitant can be decreased when combined with Ropinirole.
RopivacaineThe serum concentration of Ropivacaine can be increased when it is combined with Netupitant.
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Netupitant.
RotigotineThe serum concentration of Rotigotine can be increased when it is combined with Netupitant.
RoxithromycinThe serum concentration of Roxithromycin can be increased when it is combined with Netupitant.
RuxolitinibThe serum concentration of Ruxolitinib can be increased when it is combined with Netupitant.
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Netupitant.
SaquinavirThe serum concentration of Saquinavir can be increased when it is combined with Netupitant.
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Netupitant.
SecobarbitalThe metabolism of Netupitant can be increased when combined with Secobarbital.
SelegilineThe serum concentration of Selegiline can be increased when it is combined with Netupitant.
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Netupitant.
SeratrodastThe serum concentration of Seratrodast can be increased when it is combined with Netupitant.
SertindoleThe serum concentration of Sertindole can be increased when it is combined with Netupitant.
SertralineThe serum concentration of Sertraline can be increased when it is combined with Netupitant.
SertralineThe metabolism of Netupitant can be decreased when combined with Sertraline.
SevofluraneThe serum concentration of Sevoflurane can be increased when it is combined with Netupitant.
SibutramineThe serum concentration of Sibutramine can be increased when it is combined with Netupitant.
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Netupitant.
SildenafilThe metabolism of Netupitant can be decreased when combined with Sildenafil.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Netupitant.
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Netupitant.
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Netupitant.
SirolimusThe serum concentration of Sirolimus can be increased when it is combined with Netupitant.
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Netupitant.
SolifenacinThe serum concentration of Solifenacin can be increased when it is combined with Netupitant.
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Netupitant.
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Netupitant.
SorafenibThe metabolism of Netupitant can be decreased when combined with Sorafenib.
SpiramycinThe serum concentration of Spiramycin can be increased when it is combined with Netupitant.
StiripentolThe metabolism of Netupitant can be decreased when combined with Stiripentol.
SufentanilThe serum concentration of Sufentanil can be increased when it is combined with Netupitant.
SulfadiazineThe serum concentration of Sulfadiazine can be increased when it is combined with Netupitant.
SulfadiazineThe metabolism of Netupitant can be decreased when combined with Sulfadiazine.
SulfamethoxazoleThe serum concentration of Sulfamethoxazole can be increased when it is combined with Netupitant.
SulfamethoxazoleThe metabolism of Netupitant can be decreased when combined with Sulfamethoxazole.
SulfinpyrazoneThe serum concentration of Sulfinpyrazone can be increased when it is combined with Netupitant.
SulfisoxazoleThe metabolism of Netupitant can be decreased when combined with Sulfisoxazole.
SunitinibThe serum concentration of Sunitinib can be increased when it is combined with Netupitant.
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Netupitant.
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be increased when it is combined with Netupitant.
Synthetic Conjugated Estrogens, BThe serum concentration of Synthetic Conjugated Estrogens, B can be increased when it is combined with Netupitant.
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Netupitant.
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Netupitant.
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Netupitant.
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Netupitant.
TasosartanThe serum concentration of Tasosartan can be increased when it is combined with Netupitant.
Taurochenodeoxycholic acidThe serum concentration of Taurochenodeoxycholic acid can be increased when it is combined with Netupitant.
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Netupitant.
TelithromycinThe serum concentration of Telithromycin can be increased when it is combined with Netupitant.
TemazepamThe serum concentration of Temazepam can be increased when it is combined with Netupitant.
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Netupitant.
TeniposideThe serum concentration of Teniposide can be increased when it is combined with Netupitant.
TerbinafineThe serum concentration of Terbinafine can be increased when it is combined with Netupitant.
TerbinafineThe metabolism of Netupitant can be decreased when combined with Terbinafine.
TerfenadineThe serum concentration of Terfenadine can be increased when it is combined with Netupitant.
TesmilifeneThe serum concentration of Tesmilifene can be increased when it is combined with Netupitant.
TestosteroneThe serum concentration of Testosterone can be increased when it is combined with Netupitant.
TetracyclineThe serum concentration of Tetracycline can be increased when it is combined with Netupitant.
TheophyllineThe serum concentration of Theophylline can be increased when it is combined with Netupitant.
ThioridazineThe metabolism of Netupitant can be decreased when combined with Thioridazine.
ThiotepaThe serum concentration of Thiotepa can be increased when it is combined with Netupitant.
TiagabineThe serum concentration of Tiagabine can be increased when it is combined with Netupitant.
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Netupitant.
TicagrelorThe metabolism of Netupitant can be decreased when combined with Ticagrelor.
TiclopidineThe serum concentration of Ticlopidine can be increased when it is combined with Netupitant.
TiclopidineThe metabolism of Netupitant can be decreased when combined with Ticlopidine.
TinidazoleThe serum concentration of Tinidazole can be increased when it is combined with Netupitant.
TiotropiumThe serum concentration of Tiotropium can be increased when it is combined with Netupitant.
TipranavirThe serum concentration of Tipranavir can be increased when it is combined with Netupitant.
TipranavirThe metabolism of Netupitant can be decreased when combined with Tipranavir.
TofacitinibThe serum concentration of Tofacitinib can be increased when it is combined with Netupitant.
TolbutamideThe metabolism of Netupitant can be decreased when combined with Tolbutamide.
TolterodineThe serum concentration of Tolterodine can be increased when it is combined with Netupitant.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Netupitant.
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Netupitant.
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Netupitant.
TramadolThe serum concentration of Tramadol can be increased when it is combined with Netupitant.
TranylcypromineThe metabolism of Netupitant can be decreased when combined with Tranylcypromine.
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Netupitant.
TrazodoneThe serum concentration of Trazodone can be increased when it is combined with Netupitant.
TretinoinThe serum concentration of Tretinoin can be increased when it is combined with Netupitant.
TriamcinoloneThe serum concentration of Triamcinolone can be increased when it is combined with Netupitant.
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Netupitant.
TrimethadioneThe serum concentration of Trimethadione can be increased when it is combined with Netupitant.
TrimethoprimThe serum concentration of Trimethoprim can be increased when it is combined with Netupitant.
TrimethoprimThe metabolism of Netupitant can be decreased when combined with Trimethoprim.
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Netupitant.
TroglitazoneThe serum concentration of Troglitazone can be increased when it is combined with Netupitant.
TroleandomycinThe serum concentration of Troleandomycin can be increased when it is combined with Netupitant.
UdenafilThe serum concentration of Udenafil can be increased when it is combined with Netupitant.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Netupitant.
ValdecoxibThe serum concentration of Valdecoxib can be increased when it is combined with Netupitant.
Valproic AcidThe metabolism of Netupitant can be decreased when combined with Valproic Acid.
ValsartanThe metabolism of Netupitant can be decreased when combined with Valsartan.
VandetanibThe serum concentration of Vandetanib can be increased when it is combined with Netupitant.
VanoxerineThe serum concentration of Vanoxerine can be increased when it is combined with Netupitant.
VardenafilThe serum concentration of Vardenafil can be increased when it is combined with Netupitant.
VemurafenibThe serum concentration of Vemurafenib can be increased when it is combined with Netupitant.
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Netupitant.
VenlafaxineThe metabolism of Netupitant can be decreased when combined with Venlafaxine.
VerapamilThe serum concentration of Verapamil can be increased when it is combined with Netupitant.
VicrivirocThe serum concentration of Vicriviroc can be increased when it is combined with Netupitant.
VilanterolThe serum concentration of Vilanterol can be increased when it is combined with Netupitant.
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Netupitant.
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Netupitant.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Netupitant.
VindesineThe serum concentration of Vindesine can be increased when it is combined with Netupitant.
VinorelbineThe serum concentration of Vinorelbine can be increased when it is combined with Netupitant.
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Netupitant.
VoriconazoleThe serum concentration of Voriconazole can be increased when it is combined with Netupitant.
VoriconazoleThe metabolism of Netupitant can be decreased when combined with Voriconazole.
VortioxetineThe serum concentration of Vortioxetine can be increased when it is combined with Netupitant.
WarfarinThe serum concentration of Warfarin can be increased when it is combined with Netupitant.
YohimbineThe serum concentration of Yohimbine can be increased when it is combined with Netupitant.
ZafirlukastThe serum concentration of Zafirlukast can be increased when it is combined with Netupitant.
ZafirlukastThe metabolism of Netupitant can be decreased when combined with Zafirlukast.
ZalcitabineThe serum concentration of Zalcitabine can be increased when it is combined with Netupitant.
ZaleplonThe serum concentration of Zaleplon can be increased when it is combined with Netupitant.
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Netupitant.
ZileutonThe serum concentration of Zileuton can be increased when it is combined with Netupitant.
ZiprasidoneThe serum concentration of Ziprasidone can be increased when it is combined with Netupitant.
ZiprasidoneThe metabolism of Netupitant can be decreased when combined with Ziprasidone.
ZolpidemThe serum concentration of Zolpidem can be increased when it is combined with Netupitant.
ZomepiracThe serum concentration of Zomepirac can be increased when it is combined with Netupitant.
ZonisamideThe serum concentration of Zonisamide can be increased when it is combined with Netupitant.
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Netupitant.
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Netupitant.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Tachykinin receptor activity
Specific Function:
This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.
Gene Name:
TACR1
Uniprot ID:
P25103
Molecular Weight:
46250.5 Da
References
  1. Darmani NA, Zhong W, Chebolu S, Mercadante F: Differential and additive suppressive effects of 5-HT3 (palonosetron)- and NK1 (netupitant)-receptor antagonists on cisplatin-induced vomiting and ERK1/2, PKA and PKC activation. Pharmacol Biochem Behav. 2015 Apr;131:104-11. doi: 10.1016/j.pbb.2015.02.010. Epub 2015 Feb 14. [PubMed:25687374 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
substrate
General Function:
Monooxygenase activity
Specific Function:
Exhibits low testosterone 6-beta-hydroxylase activity.
Gene Name:
CYP3A43
Uniprot ID:
Q9HB55
Molecular Weight:
57669.21 Da
References
  1. Calcagnile S, Lanzarotti C, Rossi G, Henriksson A, Kammerer KP, Timmer W: Effect of netupitant, a highly selective NK(1) receptor antagonist, on the pharmacokinetics of palonosetron and impact of the fixed dose combination of netupitant and palonosetron when coadministered with ketoconazole, rifampicin, and oral contraceptives. Support Care Cancer. 2013 Oct;21(10):2879-87. doi: 10.1007/s00520-013-1857-9. Epub 2013 Jun 11. [PubMed:23748441 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Calcagnile S, Lanzarotti C, Rossi G, Henriksson A, Kammerer KP, Timmer W: Effect of netupitant, a highly selective NK(1) receptor antagonist, on the pharmacokinetics of palonosetron and impact of the fixed dose combination of netupitant and palonosetron when coadministered with ketoconazole, rifampicin, and oral contraceptives. Support Care Cancer. 2013 Oct;21(10):2879-87. doi: 10.1007/s00520-013-1857-9. Epub 2013 Jun 11. [PubMed:23748441 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Calcagnile S, Lanzarotti C, Rossi G, Henriksson A, Kammerer KP, Timmer W: Effect of netupitant, a highly selective NK(1) receptor antagonist, on the pharmacokinetics of palonosetron and impact of the fixed dose combination of netupitant and palonosetron when coadministered with ketoconazole, rifampicin, and oral contraceptives. Support Care Cancer. 2013 Oct;21(10):2879-87. doi: 10.1007/s00520-013-1857-9. Epub 2013 Jun 11. [PubMed:23748441 ]
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Drug created on May 04, 2015 10:50 / Updated on September 25, 2016 02:16