Iproclozide
Star1
This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Iproclozide
- DrugBank Accession Number
- DB09247
- Background
Iproclozide is an irreversible and selective hydrazine class based monoamine oxidase inhibitor (MAOI). Although it was employed as an antidepressant for a time, the fact that the agent is capable of causing fulminant hepatitis and that its use has been documented as the cause for at least three reported fatalities has resulted ultimately in the agent being discontinued.
- Type
- Small Molecule
- Groups
- Withdrawn
- Structure
- Weight
- Average: 242.7
Monoisotopic: 242.0822054 - Chemical Formula
- C11H15ClN2O2
- Synonyms
- Iproclozide
- External IDs
- PC-603
Pharmacology
- Indication
For the treatment of depression.
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your software1,2-Benzodiazepine The risk or severity of CNS depression can be increased when Iproclozide is combined with 1,2-Benzodiazepine. Acenocoumarol The risk or severity of adverse effects can be increased when Iproclozide is combined with Acenocoumarol. Acetazolamide The risk or severity of CNS depression can be increased when Acetazolamide is combined with Iproclozide. Acetophenazine The risk or severity of CNS depression can be increased when Acetophenazine is combined with Iproclozide. Agomelatine The risk or severity of CNS depression can be increased when Agomelatine is combined with Iproclozide. - Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- International/Other Brands
- Sinderesin / Sursum
Categories
- ATC Codes
- N06AF06 — Iproclozide
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as phenol ethers. These are aromatic compounds containing an ether group substituted with a benzene ring.
- Kingdom
- Organic compounds
- Super Class
- Benzenoids
- Class
- Phenol ethers
- Sub Class
- Not Available
- Direct Parent
- Phenol ethers
- Alternative Parents
- Phenoxy compounds / Chlorobenzenes / Alkyl aryl ethers / Aryl chlorides / Carboxylic acid hydrazides / Organopnictogen compounds / Organonitrogen compounds / Organochlorides / Organic oxides / Hydrocarbon derivatives show 1 more
- Substituents
- Alkyl aryl ether / Aromatic homomonocyclic compound / Aryl chloride / Aryl halide / Carbonyl group / Carboxylic acid derivative / Carboxylic acid hydrazide / Chlorobenzene / Ether / Halobenzene show 12 more
- Molecular Framework
- Aromatic homomonocyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 1II9D6CB3J
- CAS number
- 3544-35-2
- InChI Key
- GGECDTUJZOXAAR-UHFFFAOYSA-N
- InChI
- InChI=1S/C11H15ClN2O2/c1-8(2)13-14-11(15)7-16-10-5-3-9(12)4-6-10/h3-6,8,13H,7H2,1-2H3,(H,14,15)
- IUPAC Name
- 2-(4-chlorophenoxy)-N'-(propan-2-yl)acetohydrazide
- SMILES
- CC(C)NNC(=O)COC1=CC=C(Cl)C=C1
References
- General References
- Suerinck A, Suerinck E: [Depressive states in a sanatorium milieu and monoamine oxidase inhibitors. (Therapeutic results by the combination of iproclozide and chlordiazepoxide). Apropos of 146 cases]. J Med Lyon. 1966 Apr 5;47(96):573-86. [Article]
- Pessayre D, de Saint-Louvent P, Degott C, Bernuau J, Rueff B, Benhamou JP: Iproclozide fulminant hepatitis. Possible role of enzyme induction. Gastroenterology. 1978 Sep;75(3):492-6. [Article]
- External Links
- KEGG Drug
- D07338
- PubChem Compound
- 19063
- PubChem Substance
- 310265150
- ChemSpider
- 17998
- ChEBI
- 134988
- ChEMBL
- CHEMBL91238
- ZINC
- ZINC000000001577
- Wikipedia
- Iproclozide
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.2 mg/mL ALOGPS logP 1.91 ALOGPS logP 1.79 Chemaxon logS -3.1 ALOGPS pKa (Strongest Acidic) 11.58 Chemaxon pKa (Strongest Basic) 3.97 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 50.36 Å2 Chemaxon Rotatable Bond Count 5 Chemaxon Refractivity 73.21 m3·mol-1 Chemaxon Polarizability 25.21 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS splash10-004l-9620000000-ec387261a8e66031c15b Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-0006-4390000000-7b8b301d01fbceb8aa27 Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-006x-9410000000-c5298ed4ccf9a8f87a01 Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-00dl-9210000000-6a1a010464e353e71d7e Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-052f-9200000000-23b94efc7052edc31f02 Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-006x-9300000000-e38f2838e4a69761dcf7 Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-0036-9300000000-3563794a536eb3c5f91e Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 148.60811 predictedDeepCCS 1.0 (2019) [M+H]+ 150.96611 predictedDeepCCS 1.0 (2019) [M+Na]+ 157.1942 predictedDeepCCS 1.0 (2019)
Drug created at October 23, 2015 22:25 / Updated at February 21, 2021 18:52