Sulfabenzamide
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Sulfabenzamide is a sulfonamide antibacterial used as an ingredient in various topical and vaginal preparations to treat certain infections, but has been discontinued by the FDA.
- Generic Name
- Sulfabenzamide
- DrugBank Accession Number
- DB09355
- Background
Sulfabenzamide is an antimicrobial agent often used in conjunction with sulfathiazole and sulfacetamide as a topical intravaginal antibacterial preparation.
- Type
- Small Molecule
- Groups
- Approved
- Structure
- Weight
- Average: 276.311
Monoisotopic: 276.05686295 - Chemical Formula
- C13H12N2O3S
- Synonyms
- N-Benzoylsulfanilamide
- N-Sulfanilylbenzamide
- Sulfabenzamida
- Sulfabenzamide
- Sulfabenzamidum
- Sulfabenzoylamide
- Sulfamylbenzamide
- External IDs
- BRN 2139003
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Product Ingredients
Ingredient UNII CAS InChI Key Sulfabenzamide sodium ZY48TOH8CR 7257-44-5 PUTNOWNJUKOGEY-UHFFFAOYSA-M - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Gyne-Sulf Sulfabenzamide (3.7 g/100g) + Sulfacetamide (2.86 g/100g) + Sulfathiazole (3.42 g/100g) Cream Vaginal GW Laboratories, Inc. 1983-08-03 1995-09-01 US Triple Sulfa Sulfabenzamide (3.7 g/100g) + Sulfacetamide (2.86 g/100g) + Sulfathiazole (3.42 g/100g) Cream Vaginal Physicians Total Care, Inc. 1989-02-01 2004-06-30 US
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as aminobenzenesulfonamides. These are organic compounds containing a benzenesulfonamide moiety with an amine group attached to the benzene ring.
- Kingdom
- Organic compounds
- Super Class
- Benzenoids
- Class
- Benzene and substituted derivatives
- Sub Class
- Benzenesulfonamides
- Direct Parent
- Aminobenzenesulfonamides
- Alternative Parents
- Benzoic acids and derivatives / Benzenesulfonyl compounds / Benzoyl derivatives / Aniline and substituted anilines / Organosulfonic acids and derivatives / Aminosulfonyl compounds / Amino acids and derivatives / Primary amines / Organopnictogen compounds / Organooxygen compounds show 2 more
- Substituents
- Amine / Amino acid or derivatives / Aminobenzenesulfonamide / Aminosulfonyl compound / Aniline or substituted anilines / Aromatic homomonocyclic compound / Benzenesulfonyl group / Benzoic acid or derivatives / Benzoyl / Carboxylic acid derivative show 12 more
- Molecular Framework
- Aromatic homomonocyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- G58F8OPL4I
- CAS number
- 127-71-9
- InChI Key
- PBCZLFBEBARBBI-UHFFFAOYSA-N
- InChI
- InChI=1S/C13H12N2O3S/c14-11-6-8-12(9-7-11)19(17,18)15-13(16)10-4-2-1-3-5-10/h1-9H,14H2,(H,15,16)
- IUPAC Name
- N-(4-aminobenzenesulfonyl)benzamide
- SMILES
- NC1=CC=C(C=C1)S(=O)(=O)NC(=O)C1=CC=CC=C1
References
- General References
- Not Available
- External Links
- ChemSpider
- 5128
- 37320
- ChEBI
- 94677
- ChEMBL
- CHEMBL1243
- ZINC
- ZINC000005421253
- PDBe Ligand
- BS4
- Wikipedia
- Sulfabenzamide
- PDB Entries
- 3rcf
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Cream Vaginal - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.134 mg/mL ALOGPS logP 1.69 ALOGPS logP 1.59 Chemaxon logS -3.3 ALOGPS pKa (Strongest Acidic) 4.32 Chemaxon pKa (Strongest Basic) 2.09 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 89.26 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 73.15 m3·mol-1 Chemaxon Polarizability 27.32 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 169.304162 predictedDarkChem Lite v0.1.0 [M-H]- 161.51328 predictedDeepCCS 1.0 (2019) [M+H]+ 168.894962 predictedDarkChem Lite v0.1.0 [M+H]+ 163.87126 predictedDeepCCS 1.0 (2019) [M+Na]+ 169.9644 predictedDeepCCS 1.0 (2019)
Drug created at November 30, 2015 19:10 / Updated at February 21, 2021 18:52