You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on DrugBank.
Identification
NameSulfacetamide
Accession NumberDB00634  (APRD00452)
TypeSmall Molecule
GroupsApproved
Description

An anti-infective agent that is used topically to treat skin infections and orally for urinary tract infections. [PubChem]

Structure
Thumb
Synonyms
Acetosulfamine
N-((P-Aminophenyl)sulfonyl)acetamide
N-(P-Aminobenzenesulfonyl)acetamide
N-[(P-Aminophenyl)sulfonyl]acetamide
N-Acetyl-4-aminobenzenesulfonamide
N-Acetylsulfanilamide
N-Sulfanilylacetamide
N-Sulphanilylacetamide
N'-acetylsulfanilamide
N(1)-Acetyl-4-aminophenylsulfonamide
N(1)-Acetylsulfanilamide
P-Aminobenzenesulfonacetamide
P-Aminobenzenesulfonoacetamide
Sulfacetamid
Sulfacetamida
Sulfacétamide
Sulfacetamidum
Sulfanilazetamid
Sulphacetamide
Sulphacetamidum
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Balsulph Oph Liq 10.0%drops100 mgophthalmicBausch & Lomb Canada Inc.1989-12-311996-09-09Canada
Balsulph Oph Ont 10.0%ointment10 %ophthalmicBausch & Lomb Canada Inc.1989-12-311997-09-12Canada
Bleph 10 Dpsdrops10 %ophthalmicAllergan Inc1964-12-312011-08-04Canada
Bleph-10solution/ drops100 mg/mLophthalmicAllergan, Inc.1971-06-01Not applicableUs
Cetamide Ont 10%ointment10 %ophthalmicAlcon Canada Inc1972-12-312009-04-24Canada
Diosulf 10% Solutionliquid10 %ophthalmicDioptic Pharmaceuticals Inc1994-12-31Not applicableCanada
Klaronlotion100 mg/mLtopicalValeant Pharmaceuticals North America LLC1996-12-23Not applicableUs
Klaronlotion10 mg/mLtopicalPhysicians Total Care, Inc.2005-09-01Not applicableUs
Odan-sulfacetamideliquid10 %ophthalmicOdan Laboratories Ltd1985-12-31Not applicableCanada
Odan-sulfacetamideliquid10 %ophthalmicOdan Laboratories Ltd1985-12-31Not applicableCanada
Ophtho-sulf Liq 10%liquid10 %ophthalmicAltimed Pharma Inc.1986-12-311997-08-14Canada
PMS-sulfacetamide Sod Oph Soln 30%drops300 mgophthalmicPharmascience Inc1991-12-31Not applicableCanada
PMS-sulfacetamide Sodium Liq 10%liquid10 %ophthalmicPharmascience Inc1991-12-31Not applicableCanada
Sodium Sulamyd 10%drops100 mgophthalmicSandoz Canada Incorporated1951-12-31Not applicableCanada
Sodium Sulamyd Oph Dps 30%drops300 mgophthalmicSchering Plough Canada Inc1951-12-312001-07-18Canada
Sodium Sulamyd Oph Ont 10%ointment10 %ophthalmicSchering Plough Canada Inc1951-12-312001-07-18Canada
Sodium Sulfacetamidelotion100 mg/mLtopicalOceanside Pharmaceuticals2015-12-18Not applicableUs
Sodium Sulfacetamidelotion100 mg/mLtopicalPrasco Laboratories1996-12-232016-01-30Us
Sulfex 10%liquid10 %ophthalmicLaboratoires Charton Laboratories1982-12-312000-09-01Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Sulfacetamidesolution/ drops100 mg/mLophthalmicPacific Pharma2015-02-06Not applicableUs
Sulfacetamide Sodiumsuspension100 mg/mLtopicalE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.2006-11-17Not applicableUs
Sulfacetamide Sodiumsolution100 mg/mLophthalmicFalcon Pharmaceuticals, Ltd.2003-03-25Not applicableUs
Sulfacetamide Sodiumlotion100 mg/mLtopicalPerrigo New York Inc2012-10-17Not applicableUs
Sulfacetamide Sodiumsuspension100 mg/mLtopicalPhysicians Total Care, Inc.2011-01-19Not applicableUs
Sulfacetamide Sodiumsolution/ drops100 mg/mLophthalmicBausch & Lomb Incorporated1994-12-28Not applicableUs
Sulfacetamide Sodiumsolution/ drops100 mg/mLophthalmicA S Medication Solutions Llc2004-07-01Not applicableUs
Sulfacetamide Sodiumsolution100 mg/mLophthalmicRebel Distributors Corp1988-10-18Not applicableUs
Sulfacetamide Sodiumsolution100 mg/mLophthalmicH.J. Harkins Company, Inc.2003-03-25Not applicableUs
Sulfacetamide Sodiumsolution/ drops300 mg/mLophthalmicAkorn, Inc.2014-09-11Not applicableUs
Sulfacetamide Sodiumsolution/ drops100 mg/mLophthalmicREMEDYREPACK INC.2013-06-13Not applicableUs
Sulfacetamide Sodiumsolution/ drops100 mg/mLophthalmicAkorn, Inc.2014-09-11Not applicableUs
Sulfacetamide Sodiumsolution/ drops100 mg/mLophthalmicCentral Texas Community Health Centers1994-12-28Not applicableUs
Sulfacetamide Sodiumsuspension100 mg/mLtopicalTaro Pharmaceuticals U.S.A., Inc.2009-05-20Not applicableUs
Sulfacetamide Sodiumsolution/ drops100 mg/mLophthalmicSTAT Rx USA LLC1988-10-18Not applicableUs
Sulfacetamide Sodiumsolution/ drops100 mg/mLophthalmicPreferred Pharmaceuticals, Inc2012-02-28Not applicableUs
Sulfacetamide Sodiumsolution/ drops100 mg/mLophthalmicLake Erie Medical DBA Quality Care Products LLC1994-12-28Not applicableUs
Sulfacetamide Sodiumsolution/ drops100 mg/mLophthalmicMajor Pharmaceuticals2004-07-01Not applicableUs
Sulfacetamide Sodiumsolution100 mg/mLophthalmicKeltman Pharmaceuticals Inc.2010-01-10Not applicableUs
Sulfacetamide Sodiumointment100 mg/gophthalmicFera Pharmaceuticals, LLC2012-03-01Not applicableUs
Sulfacetamide Sodiumointment100 mg/gophthalmicPaddock Laboratories, LLC2014-08-13Not applicableUs
Sulfacetamide Sodiumsolution/ drops100 mg/mLophthalmicDIRECT RX2014-01-01Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Ovaceliquid100 mg/mLtopicalMission Pharmacal Company2011-09-15Not applicableUs
Ovace Plusaerosol, foam98 mg/gtopicalMission Pharmacal Company2010-07-15Not applicableUs
Ovace Plusliquid100 mg/mLtopicalMission Pharmacal Company2011-09-07Not applicableUs
Ovace Pluslotion98 mg/gtopicalMission Pharmacal Company2011-09-15Not applicableUs
Ovace Plusliquid100 mg/mLtopicalMission Pharmacal Company2011-09-15Not applicableUs
Ovace Plusshampoo100 mg/mLtopicalMission Pharmacal Company2011-09-15Not applicableUs
Ovaceplus Pluscream100 mg/gtopicalMission Pharmacal Company2011-09-15Not applicableUs
Perrigo Seb Prevgel100 mg/gtopicalPerrigo New York Inc2008-08-19Not applicableUs
Perrigo Seb Prevcream100 mg/gtopicalPerrigo New York Inc2008-08-07Not applicableUs
Seb Prev Washliquid100 mg/.95mLtopicalPerrigo New York Inc2008-07-25Not applicableUs
Sodium Sulfacetamidesolution100 mg/gtopicalE. FOUGERA & CO., A division of Nycomed US Inc.2010-03-12Not applicableUs
Sodium Sulfacetamideliquid100 mg/mLtopicalBio Comp Pharma, Inc.2011-09-07Not applicableUs
Sodium Sulfacetamideliquid100 mg/mLtopicalAcella Pharmaceuticals, LLC2010-12-14Not applicableUs
Sodium Sulfacetamideliquid100 mg/mLtopicalBio Comp Pharma, Inc.2013-01-07Not applicableUs
Sodium Sulfacetamideshampoo100 mg/mLtopicalBio Comp Pharma, Inc.2011-09-15Not applicableUs
Sodium Sulfacetamideswab100 mg/mLtopicalExact Rx, Inc.2011-08-01Not applicableUs
Sodium Sulfacetamideliquid100 mg/mLtopicalExact Rx, Inc.2011-08-01Not applicableUs
Sodium Sulfacetamideliquid100 mg/mLtopicalAUSTIN PHARMACEUTICALS, LLC2011-09-15Not applicableUs
Sodium Sulfacetamidegel100 mg/mLtopicalAcella Pharmaceuticals, LLC2010-12-14Not applicableUs
Sulfacetamide Sodiumliquid100 mg/mLtopicalBio Comp Pharma, Inc.2011-09-15Not applicableUs
International Brands
NameCompany
AcetoptSigma Pharma
AlbucidAllergan
AnginamideMedgenix
AnteborKela
ApisulfaAmman
Blef-10Allergan
BlephAllergan
CetamideAlcon
CetazinSigmapharm
OftasulDr. Collado
OptalOlan-Kemed
OvaceNot Available
RiacetamidRiyadh Pharma
SulfacilFarmak
SulphacalyreWallace
UnisulfRoster
Brand mixtures
NameLabellerIngredients
AvarMission Pharmacal Company
Avar Cleansing PadsMission Pharmacal Company
Avar LsMission Pharmacal Company
Avar Ls Cleansing PadsMission Pharmacal Company
Avar-EMission Pharmacal Company
Avar-E GreenMission Pharmacal Company
Avar-E LsMission Pharmacal Company
BlephamideAllergan, Inc.
Blephamide Oph OntAllergan Inc
Blephamide Opht SuspensionAllergan Inc
Bp Cleansing WashAcella Pharmaceuticals, LLC
CleniaUpsher Smith Laboratories, Inc
Dioptimyd OintmentDioptic Pharmaceuticals Inc
Dioptimyd SuspensionDioptic Pharmaceuticals Inc
Metimyd Oph SusSchering Plough Canada Inc
Odan-cideOdan Laboratories Ltd
Perrigo Sodium Sulfacetamide and SulfurPerrigo New York Inc
PlexionBrava Pharmaceuticals, Llc
Prascion CleanserPrasco Laboratories
Prascion FcPrasco Laboratories
Prascion RaPrasco Laboratories
RosanilGalderma Laboratories, L.P.
RosulaAvion Pharmaceuticals, Llc
Rosula WashAvion Pharmaceuticals, Llc
Sodium Sulfacetamide - Sulfur Cleansing PadsAcella Pharmaceuticals, LLC
Sodium Sulfacetamide - Sulfur WashACELLA PHARMACEUTICALS
Sodium Sulfacetamide 10 and Sulfur 5Perrigo New York Inc
Sodium Sulfacetamide 10 Sulfur 2 CleanserAcella Pharmaceuticals, LLC
Sodium Sulfacetamide 10 Sulfur 2 CreamAcella Pharmaceuticals, LLC
Sodium Sulfacetamide 10 Sulfur 5Acella Pharmaceuticals, LLC
Sodium Sulfacetamide 10 Sulfur 5 CleanserAcella Pharmaceuticals, LLC
Sodium Sulfacetamide 9 Sulfur 4.5 WashAcella Pharmaceuticals, LLC
Sodium Sulfacetamide 9.8% and Sulfur 4.8%Rosemar Labs, LLC
Sodium Sulfacetamide 9.8% and Sulfur 4.8% CleanserRosemar Labs, LLC
Sodium Sulfacetamide 9.8% and Sulfur 4.8% CreamRosemar Labs, LLC
Sodium Sulfacetamide and SulfurSeton Pharmaceuticals
Sodium Sulfacetamide and Sulfur 10 Percent and 2 Percent CleanserMethod Pharmaceuticals, Llc
Sodium Sulfacetamide and Sulfur 10 Percent and 5 Percent CleanserMethod Pharmaceuticals, Llc
Sodium Sulfacetamide and Sulfur CleanserBi Coastal Pharma International Llc
Sodium Sulfacetamide and Sulfur External CreamCameron Pharmaceuticals, Llc
Sodium Sulfacetamide and Sulfur External LiquidCameron Pharmaceuticals, Llc
Sodium Sulfacetamide and Sulfur Topical SuspensionRochester Pharmaceuticals
Sodium Sulfacetamide and Sulfur WashAcella Pharmaceuticals, LLC
Sodium Sulfacetamide, SulfurAcella Pharmaceuticals, LLC
Sulfacet R LotionRhone Poulenc Rorer Consumer Inc.
Sulfacet-RValeant Canada Lp Valeant Canada S.E.C.
Sulfacetamide Sodium and Prednisolone Sodium PhosphateRebel Distributors Corp
Sulfacetamide Sodium and SulfurBi Coastal Pharma International Llc
Sulfacetamide Sodium, SulfurBio Comp Pharma, Inc.
Sulfacleanse 8/4Pru Gen, Inc.
SulfixJourney Medical Corporation
SumadanMedimetriks Pharmaceuticals Inc.
Sumadan WashMedimetriks Pharmaceuticals Inc.
Sumadan XltMedimetriks Pharmaceuticals Inc.
Sumaxin Cleansing PadsMedimetriks Pharmaceuticals, Inc.
Sumaxin CpMedimetriks Pharmaceuticals, Inc.
Sumaxin TsMedimetriks Pharmaceuticals, Inc.
Vasocidin Ophthalmic SolutionIolab Pharmaceuticals
Vasosulf Oph SolnIolab Pharmaceuticals
Virti-sulfVirtus Pharmaceuticals
Zencia WashStratus Pharamceuticals, Inc
Salts
Name/CASStructureProperties
Sulfacetamide sodium
ThumbNot applicableDBSALT000986
Categories
UNII4965G3J0F5
CAS number144-80-9
WeightAverage: 214.242
Monoisotopic: 214.041212886
Chemical FormulaC8H10N2O3S
InChI KeyInChIKey=SKIVFJLNDNKQPD-UHFFFAOYSA-N
InChI
InChI=1S/C8H10N2O3S/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8/h2-5H,9H2,1H3,(H,10,11)
IUPAC Name
N-(4-aminobenzenesulfonyl)acetamide
SMILES
CC(=O)NS(=O)(=O)C1=CC=C(N)C=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as aminobenzenesulfonamides. These are organic compounds containing a benzenesulfonamide moiety with an amine group attached to the benzene ring.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassBenzenesulfonamides
Direct ParentAminobenzenesulfonamides
Alternative Parents
Substituents
  • Aminobenzenesulfonamide
  • Sulfonylaniline
  • Substituted aniline
  • Aniline
  • Primary aromatic amine
  • Acetamide
  • Aminosulfonyl compound
  • Sulfonyl
  • Sulfonic acid derivative
  • Sulfonamide
  • Carboxamide group
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Primary amine
  • Organosulfur compound
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of bacterial vaginitis, keratitis, acute conjunctivitis, and blepharitis.
PharmacodynamicsSulfacetamide is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Mechanism of actionSulfacetamide is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), an essential component for bacterial growth (according to the Woods-Fildes theory). The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half life7-12.8 hours
ClearanceNot Available
ToxicityOral LD50 Mouse : 16500 mg/kg. Side effects include moderate to severe erythema (redness) and moderate edema (raised kin), nausea, vomiting, headache, dizziness, and tiredness. Higher exposure causes unconsciousness.
Affected organisms
  • Enteric bacteria and other eubacteria
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9912
Blood Brain Barrier+0.9881
Caco-2 permeable-0.5396
P-glycoprotein substrateNon-substrate0.8806
P-glycoprotein inhibitor INon-inhibitor0.9743
P-glycoprotein inhibitor IINon-inhibitor0.9449
Renal organic cation transporterNon-inhibitor0.9484
CYP450 2C9 substrateNon-substrate0.6975
CYP450 2D6 substrateNon-substrate0.9058
CYP450 3A4 substrateNon-substrate0.7775
CYP450 1A2 substrateNon-inhibitor0.9609
CYP450 2C9 inhibitorNon-inhibitor0.9595
CYP450 2D6 inhibitorNon-inhibitor0.9312
CYP450 2C19 inhibitorNon-inhibitor0.9546
CYP450 3A4 inhibitorNon-inhibitor0.9552
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8371
Ames testNon AMES toxic0.9279
CarcinogenicityNon-carcinogens0.8623
BiodegradationNot ready biodegradable0.9686
Rat acute toxicity1.7849 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9919
hERG inhibition (predictor II)Non-inhibitor0.9775
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Sanofi aventis us llc
  • Altana inc
  • Perrigo co tennessee inc
  • Taro pharmaceuticals usa inc
  • Allergan pharmaceutical
  • Alcon laboratories inc
  • Schering corp sub schering plough corp
  • Pharmafair inc
  • Allergan
  • Miza pharmaceuticals usa inc
  • Akorn inc
  • Sola barnes hind
  • Novartis pharmaceuticals corp
  • Optopics laboratories corp
  • Alcon inc
  • Alcon universal ltd
  • Bausch and lomb pharmaceuticals inc
  • Bausch and lomb inc
Packagers
Dosage forms
FormRouteStrength
Aerosol, foamtopical
Emulsiontopical
Clothtopical
Creamtopical
Dropsophthalmic10 %
Ointmentophthalmic
Suspension/ dropsophthalmic
Dropsophthalmic
Liquidtopical
Ointmentophthalmic10 %
Ointmentophthalmic; topical
Suspensionophthalmic
Lotiontopical10 mg/mL
Lotiontopical100 mg/mL
Aerosol, foamtopical98 mg/g
Liquidtopical100 mg/mL
Lotiontopical98 mg/g
Shampootopical100 mg/mL
Creamtopical100 mg/g
Geltopical100 mg/g
Dropsophthalmic300 mg
Liquidophthalmic10 %
Soaptopical
Solutiontopical
Liquidtopical100 mg/.95mL
Dropsophthalmic100 mg
Geltopical100 mg/mL
Solutiontopical100 mg/g
Swabtopical100 mg/mL
Swabtopical
Rinsetopical
Geltopical
Suspensiontopical
Ointmentophthalmic100 mg/g
Solutionophthalmic100 mg/mL
Solution/ dropsophthalmic100 mg/mL
Solution/ dropsophthalmic300 mg/mL
Suspensiontopical100 mg/mL
Solutionophthalmic
Solution/ dropsophthalmic
Lotiontopical
Kit
Liquidophthalmic
Prices
Unit descriptionCostUnit
Klaron 10% Lotion 118ml Bottle155.38USD bottle
Sulfacetamide-Sulfur Wash 10-4% Emulsion 473ml Bottle138.03USD bottle
Sulfacetamide Sodium-Sulfur 10-5% Lotion 25 gm Bottle70.99USD bottle
Sulfacetamide Sodium-Sulfur 10-5% Suspension 30 gm Tube70.57USD tube
Sulfacetamide Sodium-Sulfur 10-5% Lotion 30 gm Tube63.38USD tube
Sulfacetamide Sod-Sulfur Wash 10-5% Emulsion 170.1 gm Tube55.94USD tube
Bleph-10 10% Solution 5ml Bottle22.7USD bottle
Sulfacetamide Sodium 10% Solution 15ml Bottle12.99USD bottle
Bleph-10 10% eye drops3.89USD ml
Sulfacetamide powder1.55USD g
Klaron 10% lotion1.29USD ml
Sulfacetamide sod cryst powder0.98USD g
Sodium sulfacetamide 10% lot0.94USD ml
Sulfacetamide sod 10% top susp0.8USD ml
Ovace wash 10% liquid0.44USD ml
Re 10 wash0.42USD ml
Sulfacetamide 10% eye drops0.34USD ml
Sulfacetamide 10% ophth sol0.34USD ml
Sulfamide 10% eye drops0.22USD ml
Sodium sulfacetamide powder0.1USD g
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point183 °CPhysProp
water solubility1.25E+004 mg/L (at 37 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP-0.96HANSCH,C ET AL. (1995)
logS-1.23ADME Research, USCD
Predicted Properties
PropertyValueSource
Water Solubility4.21 mg/mLALOGPS
logP0.15ALOGPS
logP-0.26ChemAxon
logS-1.7ALOGPS
pKa (Strongest Acidic)4.3ChemAxon
pKa (Strongest Basic)2.14ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area89.26 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity52.48 m3·mol-1ChemAxon
Polarizability20.49 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (9.68 KB)
SpectraNot Available
References
Synthesis ReferenceNot Available
General References
  1. Hull CA, Johnson SM: A double-blind comparative study of sodium sulfacetamide lotion 10% versus selenium sulfide lotion 2.5% in the treatment of pityriasis (tinea) versicolor. Cutis. 2004 Jun;73(6):425-9. [PubMed:15224788 ]
  2. Del Rosso JQ: Evaluating the role of topical therapies in the management of rosacea: focus on combination sodium sulfacetamide and sulfur formulations. Cutis. 2004 Jan;73(1 Suppl):29-33. [PubMed:14959943 ]
  3. Roth HW, Leimbeck R, Sonnenschein B, Anger CB, Weber S: [The effective antibacterial spectrum of sulfacetamide]. Klin Monbl Augenheilkd. 1992 Mar;200(3):182-6. [PubMed:1578876 ]
External Links
ATC CodesD10AF06S01AB04
AHFS Codes
  • 52:04.04
PDB Entries
FDA labelDownload (455 KB)
MSDSDownload (72.7 KB)
Interactions
Drug Interactions
Drug
MecamylamineThe risk or severity of adverse effects can be increased when Sulfacetamide is combined with Mecamylamine.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
yes
Actions
inhibitor
General Function:
Metal ion binding
Specific Function:
Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Gene Name:
folP
Uniprot ID:
P0AC13
Molecular Weight:
30614.855 Da
References
  1. Hevener KE, Zhao W, Ball DM, Babaoglu K, Qi J, White SW, Lee RE: Validation of molecular docking programs for virtual screening against dihydropteroate synthase. J Chem Inf Model. 2009 Feb;49(2):444-60. doi: 10.1021/ci800293n. [PubMed:19434845 ]
  2. BROWN GM: The biosynthesis of folic acid. II. Inhibition by sulfonamides. J Biol Chem. 1962 Feb;237:536-40. [PubMed:13873645 ]
  3. Patel OG, Mberu EK, Nzila AM, Macreadie IG: Sulfa drugs strike more than once. Trends Parasitol. 2004 Jan;20(1):1-3. [PubMed:14700578 ]
Kind
Protein
Organism
Escherichia coli
Pharmacological action
yes
Actions
inhibitor
General Function:
Metal ion binding
Specific Function:
Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives (By similarity). It is implicated in resistance to sulfonamide. The type II enzyme is stable whereas type I DHPS loses its activity rapidly.
Gene Name:
sulI
Uniprot ID:
P0C002
Molecular Weight:
30125.83 Da
References
  1. Patel OG, Mberu EK, Nzila AM, Macreadie IG: Sulfa drugs strike more than once. Trends Parasitol. 2004 Jan;20(1):1-3. [PubMed:14700578 ]
Kind
Protein
Organism
Baker's yeast
Pharmacological action
yes
Actions
inhibitor
General Function:
Metal ion binding
Specific Function:
Catalyzes three sequential steps of tetrahydrofolate biosynthesis.
Gene Name:
FOL1
Uniprot ID:
P53848
Molecular Weight:
93119.085 Da
References
  1. Patel OG, Mberu EK, Nzila AM, Macreadie IG: Sulfa drugs strike more than once. Trends Parasitol. 2004 Jan;20(1):1-3. [PubMed:14700578 ]
Comments
comments powered by Disqus
Drug created on June 13, 2005 07:24 / Updated on September 16, 2013 17:11