NAV

Modified vaccinia ankara

Identification

Summary

Modified vaccinia ankara is a live, non-replicating orthopoxvirus vaccine used to prevent smallpox, monkeypox, and other diseases caused by vaccinia virus.

Brand Names
Jynneos
Generic Name
Modified vaccinia ankara
DrugBank Accession Number
DB15483
Background

Modified Vaccinia Ankara (MVA) refers to an attenuated strain of the Vaccinia virus. Vaccines using MVA are live and non-replicating, and are produced using Modified Vaccinia Ankara-Bavarian Nordic (MVA-BN).2,3

Type
Biotech
Groups
Approved
Biologic Classification
Vaccines
Attenuated
Synonyms
  • Modified Vaccinia Virus (Ankara-Bavarian Nordic)
  • MVA
  • MVA-BN
  • Vaccinia strain modified ankara
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Pharmacology

Indication

Modified vaccinia ankara is a vaccine indicated for the prevention of smallpox and monkeypox disease in adults 18 years of age and older determined to be at high risk for smallpox or monkeypox infection.1 In the EU, it is additionally indicated for the prevention of other diseases caused by the vaccinia virus.3

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Used in combination to preventEbola virus infectionRegimen in combination with: Ebola Zaire vaccine (live, attenuated) (DB15595)•••••••••••••••••••••• ••••••••••
Prevention ofMonkeypox••••••••••••••••••••• •••••••••••••• ••••••••••
Prevention ofSmallpox••••••••••••••••••••••••••••••••• •• ••••• •• •••••• •••••••••• •••••••• •••••••••••••••••• ••••••••••• ••••••••••
Prevention ofVariola major (smallpox)••••••••••••••••••••• •••• ••• •••••••• ••••••••••••••••••• ••••••••••
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action

Vaccination with Modified Vaccinia Ankara elicits humoral and cellular immune responses to orthopoxviruses, thereby providing host protection against future orthopoxvirus infections.1

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
Integrate drug-drug
interactions in your software
AbataceptThe therapeutic efficacy of Modified vaccinia ankara can be decreased when used in combination with Abatacept.
AdalimumabThe therapeutic efficacy of Modified vaccinia ankara can be decreased when used in combination with Adalimumab.
Adenovirus type 7 vaccine liveThe therapeutic efficacy of Adenovirus type 7 vaccine live can be decreased when used in combination with Modified vaccinia ankara.
AldesleukinThe therapeutic efficacy of Modified vaccinia ankara can be decreased when used in combination with Aldesleukin.
AlefaceptThe therapeutic efficacy of Modified vaccinia ankara can be decreased when used in combination with Alefacept.
Food Interactions
Not Available

Products

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Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
ImvamuneSuspension50000000 CCID50 / 0.5 mLSubcutaneousBavarian Nordic As2015-06-15Not applicableCanada flag
ImvanexInjection, suspension50000000 Inf. USubcutaneousBavarian Nordic A/S2020-12-18Not applicableEU flag
JynneosInjection, suspension50000000 1/0.5mLSubcutaneousBavarian Nordic A/S2021-03-17Not applicableUS flag
MvabeaInjection, suspension70000000 Inf. UIntramuscularJanssen Cilag International Nv2021-02-11Not applicableEU flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
  • Humans and other mammals

Chemical Identifiers

UNII
TU8J357395
CAS number
Not Available

References

General References
  1. DailyMed Label: JYNNEOS (Smallpox and Monkeypox Vaccine, Live, Non-replicating) suspension for subcutaneous injection [Link]
  2. FDA Approved Drug Products: Jynneos (smallpox and monkeypox vaccine, live, non-replicating) for suspension for subcutaneous injection [Link]
  3. EMA Summary of Product Characteristics: Imvanex (Smallpox and monkeypox vaccine (Live Modified Vaccinia Virus Ankara)) for subcutaneous injection [Link]
  4. Health Canada Product Monograph: IMVAMUNE (modified vaccinia ankara) injection [Link]
RxNav
1668221

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedPreventionVaccinations1
4Not Yet RecruitingPreventionMonkeypox1
4RecruitingPreventionMonkeypox1
3Active Not RecruitingPreventionMonkeypox Virus Infection1
3CompletedPrevention18-42 Year Old Healthy Vaccinia-naïve Subjects1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
SuspensionSubcutaneous50000000 CCID50 / 0.5 mL
Injection, suspensionSubcutaneous50000000 U.inf.
Injection, suspensionSubcutaneous50000000 Inf. U
Injection, suspensionSubcutaneous50000000 1/0.5mL
Injection, suspensionIntramuscular0.5 ML
Injection, suspensionIntramuscular70000000 Inf. U
Prices
Not Available
Patents
Not Available

Properties

State
Liquid
Experimental Properties
Not Available

Drug created at August 30, 2019 17:59 / Updated at December 01, 2022 11:29