Sulfamethylthiazole
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Sulfamethylthiazole is an antibiotic indicated to prevent postoperative ocular infections or treat ocular infections.
- Generic Name
- Sulfamethylthiazole
- DrugBank Accession Number
- DB15882
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
- Weight
- Average: 269.34
Monoisotopic: 269.029268954 - Chemical Formula
- C10H11N3O2S2
- Synonyms
- 4-Amino-N-(4-methyl-2-thiazolyl)benzenesulfonamide
- N(sup 1)-(4-Methyl-2-thiazolyl)sulfanilamide
- Sulfamethylthiazole
- Sulfazole
- External IDs
- Ciba 3753
- RP 146
- RP-146
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Used in combination for prophylaxis of Eye infections Combination Product in combination with: Tetracycline (DB00759) •••••••••••• •••••••• Used in combination to treat Eye infections Combination Product in combination with: Tetracycline (DB00759) •••••••••••• •••••••• Used as adjunct in combination to treat Trachoma Combination Product in combination with: Tetracycline (DB00759) •••••••••••• •••••••• - Contraindications & Blackbox Warnings
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Product Ingredients
Ingredient UNII CAS InChI Key Sulfamethylthiazole sodium 8N35S1D1BL 58944-02-8 WSHBUVWBGHKXLX-UHFFFAOYSA-N - International/Other Brands
- Neodiseptal / Novoseptale / Staphylamid / Toriseptin M / Ultraseptal / Ultraseptyl
Categories
- Drug Categories
- Not Available
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- R12OZ3O07F
- CAS number
- 515-59-3
- InChI Key
- KJVQYDYPDFFJMP-UHFFFAOYSA-N
- InChI
- InChI=1S/C10H11N3O2S2/c1-7-6-16-10(12-7)13-17(14,15)9-4-2-8(11)3-5-9/h2-6H,11H2,1H3,(H,12,13)
- IUPAC Name
- 4-amino-N-(4-methyl-1,3-thiazol-2-yl)benzene-1-sulfonamide
- SMILES
- CC1=CSC(NS(=O)(=O)C2=CC=C(N)C=C2)=N1
References
- General References
- AIFA Product Information: PENSULVIT SIFI (sulfamethylthiazole and tetracycline) ophthalmic ointment [Link]
- External Links
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Ointment Ophthalmic - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.405 mg/mL ALOGPS logP 1.06 ALOGPS logP 1.11 Chemaxon logS -2.8 ALOGPS pKa (Strongest Acidic) 6.93 Chemaxon pKa (Strongest Basic) 2.06 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 85.08 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 66.86 m3·mol-1 Chemaxon Polarizability 26.06 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-0ab9-0940000000-9a53e62da56eac6e3259 Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-014i-0090000000-0130664c99117e2c4e38 Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-0a4i-0920000000-d16fbed02f76d21c114a Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-00kb-1950000000-3de2712b0ab588f6c75c Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-014i-9000000000-06ee3abe06babc54e9c3 Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-00r2-5900000000-b76d3808abe3e4650952 Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 168.1644188 predictedDarkChem Lite v0.1.0 [M+H]+ 168.9547188 predictedDarkChem Lite v0.1.0 [M+Na]+ 168.2254188 predictedDarkChem Lite v0.1.0
Drug created at September 24, 2020 18:14 / Updated at May 07, 2021 21:08