Thiamine disulfide
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Thiamine disulfide is a B-vitamin indicated to treat neurological conditions caused by B vitamin deficiency.
- Generic Name
- Thiamine disulfide
- DrugBank Accession Number
- DB15958
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
- Weight
- Average: 562.71
Monoisotopic: 562.214443955 - Chemical Formula
- C24H34N8O4S2
- Synonyms
- Thiamine disulfide
- Vitamin B1 disulfide
- External IDs
- 200-644-4
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Arca-Be Dragees Thiamine disulfide (100 mg) + Cyanocobalamin (200 μg) + Pyridoxine hydrochloride (200 mg) Tablet, coated Oral Arcana Arzneimittel Gmb H 1995-08-23 Not applicable Austria NEUROBION TABLET Thiamine disulfide (100 mg) + Cyanocobalamin (200 mcg) + Pyridoxine hydrochloride (200 mg) Tablet, sugar coated Oral PROCTER & GAMBLE (SINGAPORE ) PTE LTD 1991-06-21 Not applicable Singapore NEUROBION TABLET (OTC) Thiamine disulfide (100 mg) + Cyanocobalamin (200 mcg) + Pyridoxine hydrochloride (200 mg) Tablet, sugar coated Oral PROCTER & GAMBLE (SINGAPORE ) PTE LTD 2016-10-13 Not applicable Singapore
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- UJV8K21YKL
- CAS number
- 67-16-3
- InChI Key
- GFEGEDUIIYDMOX-BMJUYKDLSA-N
- InChI
- InChI=1S/C24H34N8O4S2/c1-15(31(13-35)11-19-9-27-17(3)29-23(19)25)21(5-7-33)37-38-22(6-8-34)16(2)32(14-36)12-20-10-28-18(4)30-24(20)26/h9-10,13-14,33-34H,5-8,11-12H2,1-4H3,(H2,25,27,29)(H2,26,28,30)/b21-15-,22-16-
- IUPAC Name
- N-[(4-amino-2-methylpyrimidin-5-yl)methyl]-N-[(2Z)-3-{[(2Z)-2-{N-[(4-amino-2-methylpyrimidin-5-yl)methyl]formamido}-5-hydroxypent-2-en-3-yl]disulfanyl}-5-hydroxypent-2-en-2-yl]formamide
- SMILES
- C\C(N(CC1=C(N)N=C(C)N=C1)C=O)=C(/CCO)SS\C(CCO)=C(\C)N(CC1=C(N)N=C(C)N=C1)C=O
References
- General References
- BASG: Arca-Be (Cyanocobalamin, Pyridoxine, Thiamine) Oral Tablet [Link]
- External Links
- ChemSpider
- 2301699
- 38041
- ChEMBL
- CHEMBL416503
- ZINC
- ZINC000003873942
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Tablet, coated Oral Tablet, sugar coated Oral - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.259 mg/mL ALOGPS logP 0.9 ALOGPS logP -2.4 Chemaxon logS -3.3 ALOGPS pKa (Strongest Acidic) 15.6 Chemaxon pKa (Strongest Basic) 6.96 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 10 Chemaxon Hydrogen Donor Count 4 Chemaxon Polar Surface Area 184.68 Å2 Chemaxon Rotatable Bond Count 13 Chemaxon Refractivity 159.26 m3·mol-1 Chemaxon Polarizability 56.97 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at November 26, 2020 21:45 / Updated at May 07, 2021 21:09