Monocarboxylate transporter 5
Details
- Name
- Monocarboxylate transporter 5
- Synonyms
- MCT 4
- MCT 5
- MCT4
- MCT5
- Monocarboxylate transporter 4
- Solute carrier family 16 member 4
- Gene Name
- SLC16A4
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0000389|Monocarboxylate transporter 5 MLKREGKVQPYTKTLDGGWGWMIVIHFFLVNVFVMGMTKTFAIFFVVFQEEFEGTSEQIG WIGSIMSSLRFCAGPLVAIICDILGEKTTSILGAFVVTGGYLISSWATSIPFLCVTMGLL PGLGSAFLYQVAAVVTTKYFKKRLALSTAIARSGMGLTFLLAPFTKFLIDLYDWTGALIL FGAIALNLVPSSMLLRPIHIKSENNSGIKDKGSSLSAHGPEAHATETHCHETEESTIKDS TTQKAGLPSKNLTVSQNQSEEFYNGPNRNRLLLKSDEESDKVISWSCKQLFDISLFRNPF FYIFTWSFLLSQLAYFIPTFHLVARAKTLGIDIMDASYLVSVAGILETVSQIISGWVADQ NWIKKYHYHKSYLILCGITNLLAPLATTFPLLMTYTICFAIFAGGYLALILPVLVDLCRN STVNRFLGLASFFAGMAVLSGPPIAGWLYDYTQTYNGSFYFSGICYLLSSVSFFFVPLAE RWKNSLT
- Number of residues
- 487
- Molecular Weight
- 54021.43
- Theoretical pI
- 8.13
- GO Classification
- Functionsmonocarboxylic acid transmembrane transporter activity / symporter activityProcessesion transmembrane transport / monocarboxylic acid transportComponentsintegral component of plasma membrane / membrane
- General Function
- Symporter activity
- Specific Function
- Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).
- Pfam Domain Function
- MFS_1 (PF07690)
- Transmembrane Regions
- 17-37 60-80 88-108 110-129 144-164 175-195 300-320 338-358 373-393 395-415 426-446 459-479
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0016030|Monocarboxylate transporter 5 (SLC16A4) ATGCTGAAGAGGGAGGGGAAGGTCCAACCTTACACTAAAACCCTGGATGGAGGATGGGGA TGGATGATTGTGATTCATTTTTTCCTGGTGAATGTGTTTGTGATGGGGATGACCAAGACT TTTGCAATTTTCTTTGTGGTCTTTCAAGAAGAGTTTGAAGGCACCTCAGAGCAAATTGGT TGGATTGGATCCATCATGTCATCTCTTCGTTTTTGTGCAGGTTTGGGTTCTGCTTTCTTA TACCAAGTGGCTGCTGTGGTAACTACCAAATACTTCAAAAAACGATTGGCTCTTTCTACA GCTATTGCCCGTTCTGGGATGGGACTGACTTTTCTTTTGGCACCCTTTACAAAATTCCTG ATAGATCTGTATGACTGGACAGGAGCCCTTATATTATTTGGAGCTATCGCATTGAATTTG GTGCCTTCTAGTATGCTCTTAAGACCCATCCATATCAAAAGTGAGAACAATTCTGGTATT AAAGATAAAGGCAGCAGTTTGTCTGCACATGGTCCAGAGGCACATGCAACAGAAACACAC TGCCATGAGACAGAAGAGTCTACCATCAAGGACAGTACTACGCAGAAGGCTGGACTACCT AGCAAAAATTTAACAGTCTCACAAAATCAAAGTGAAGAGTTCTACAATGGGCCTAACAGG AACAGACTGTTATTAAAGAGTGATGAAGAAAGTGATAAGGTTATTTCGTGGAGCTGCAAA CAACTGTTTGACATTTCTCTCTTTAGAAATCCTTTCTTCTACATATTTACTTGGTCTTTT CTCCTCAGTCAGTTAGCATACTTCATCCCTACCTTTCACCTGGTAGCCAGAGCCAAAACA CTGGGGATTGACATCATGGATGCCTCTTACCTTGTTTCTGTAGCAGGTATCCTTGAGACG GTCAGTCAGATTATTTCTGGATGGGTTGCTGATCAAAACTGGATTAAGAAGTATCATTAC CACAAGTCTTACCTCATCCTCTGCGGCATCACTAACCTGCTTGCTCCTTTAGCCACCACA TTTCCACTACTTATGACCTACACCATCTGCTTTGCCATCTTTGCTGGTGGTTACCTGGCA TTGATACTGCCTGTACTGGTTGATCTGTGTAGGAATTCTACAGTAAACAGGTTTTTGGGA CTTGCCAGTTTCTTTGCTGGGATGGCTGTCCTTTCTGGACCACCTATAGCAGGCTGGTTA TATGATTATACCCAGACATACAATGGCTCTTTCTACTTCTCTGGCATATGCTATCTCCTC TCTTCAGTTTCCTTTTTTTTTGTACCATTGGCCGAAAGATGGAAAAACAGTCTGACCTGA
- Chromosome Location
- 1
- Locus
- 1p13.3
- External Identifiers
Resource Link UniProtKB ID O15374 UniProtKB Entry Name MOT5_HUMAN GenBank Protein ID 2463628 GenBank Gene ID U59185 GenAtlas ID SLC16A4 HGNC ID HGNC:10925 - General References
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