Ribosomal protein S6 kinase alpha-4
Details
- Name
- Ribosomal protein S6 kinase alpha-4
- Synonyms
- 2.7.11.1
- 90 kDa ribosomal protein S6 kinase 4
- MSK2
- Nuclear mitogen- and stress-activated protein kinase 2
- Ribosomal protein kinase B
- RSKB
- S6K-alpha-4
- Gene Name
- RPS6KA4
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0009533|Ribosomal protein S6 kinase alpha-4 MGDEDDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGK LYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSG GEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDF GLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTL EGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPF FQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYS FVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQDSPFFQQYELDLREPALGQG SFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTY LVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYAD DTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILY MMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPA KRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLK SVENAPLAKRRKQKLRSATASRRGSPAPANPGRAPVASKGAPRRANGPLPPS
- Number of residues
- 772
- Molecular Weight
- 85605.025
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / histone kinase activity (H3-S10 specific) / magnesium ion binding / mitogen-activated protein kinase p38 binding / protein serine/threonine kinase activity / ribosomal protein S6 kinase activityProcessesaxon guidance / histone H3-S10 phosphorylation / histone H3-S28 phosphorylation / histone phosphorylation / inflammatory response / interleukin-1-mediated signaling pathway / intracellular signal transduction / negative regulation of cytokine production / positive regulation of CREB transcription factor activity / positive regulation of histone acetylation / positive regulation of histone phosphorylation / positive regulation of NF-kappaB transcription factor activity / positive regulation of transcription from RNA polymerase II promoter / protein phosphorylation / regulation of transcription, DNA-templatedComponentscytoplasm / nucleoplasm / nucleus
- General Function
- Ribosomal protein s6 kinase activity
- Specific Function
- Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0013218|Ribosomal protein S6 kinase alpha-4 (RPS6KA4) ATGGGGGACGAGGACGACGATGAGAGCTGCGCCGTGGAGCTGCGGATCACAGAAGCCAAC CTGACCGGGCACGAGGAGAAGGTGAGCGTGGAGAACTTCGAGCTGCTCAAGGTGCTGGGC ACGGGAGCCTACGGCAAGGTGTTCCTGGTGCGGAAGGCGGGCGGGCACGACGCGGGGAAG CTGTACGCCATGAAGGTGCTGCGCAAGGCGGCGCTGGTGCAGCGCGCCAAGACGCAAGAG CACACGCGCACCGAGCGCTCGGTGCTGGAGCTGGTGCGCCAGGCGCCCTTCCTGGTCACG CTGCACTACGCTTTCCAGACGGATGCCAAGCTGCACCTCATCCTGGACTATGTGAGCGGC GGGGAGATGTTCACCCACCTCTACCAGCGCCAGTACTTCAAGGAGGCTGAGGTGCGCGTG TATGGGGGTGAGATCGTGCTGGCCCTGGAACACCTGCACAAGCTCGGCATCATTTACCGA GACCTGAAACTGGAGAATGTGCTGCTGGACTCCGAGGGCCACATTGTCCTCACGGACTTC GGGCTGAGCAAGGAGTTCCTGACGGAGGAGAAAGAGCGGACCTTCTCCTTCTGTGGCACC ATCGAGTACATGGCCCCCGAAATCATCCGTAGCAAGACGGGGCATGGCAAGGCTGTGGAC TGGTGGAGCCTGGGCATCTTGCTCTTCGAGCTGCTGACGGGGGCCTCGCCCTTCACCCTG GAGGGCGAGAGGAACACGCAGGCTGAGGTGTCTCGACGGATCCTGAAGTGCTCCCCTCCC TTCCCCCCTCGGATCGGGCCCGTGGCGCAGGACCTGCTGCAGCGGCTGCTTTGTAAGGAT CCTAAGAAGCGATTGGGCGCGGGGCCCCAGGGGGCACAAGAAGTCCGGAACCATCCCTTC TTCCAGGGCCTCGATTGGGTGGCTCTGGCTGCCAGGAAGATTCCAGCCCCATTCCGGCCC CAAATCCGCTCAGAGCTGGATGTGGGCAACTTTGCGGAGGAATTCACTCGGCTGGAGCCT GTCTACTCACCCCCTGGCAGCCCCCCACCTGGGGACCCCCGAATCTTTCAGGGATACTCC TTTGTGGCACCCTCCATTCTCTTTGACCACAACAACGCGGTGATGACCGATGGGCTGGAA GCGCCTGGTGCTGGAGACCGGCCAGGTCGGGCAGCGGTGGCCAGGAGCGCTATGATGCAG CAGTACGAGCTGGACCTGCGGGAGCCTGCGCTGGGCCAGGGCAGCTTTTCTGTGTGTCGC CGCTGCCGCCAGCGCCAGAGCGGCCAGGAGTTCGCAGTCAAGATCCTCAGTCGCAGGCTG GAGGCGAACACGCAGCGCGAAGTGGCTGCCCTGCGCCTGTGCCAGTCACACCCCAACGTG GTGAATCTGCACGAGGTGCATCACGACCAGCTGCACACGTACCTGGTCCTGGAGCTGCTG CGGGGCGGGGAGCTGCTGGAGCACATCCGCAAGAAGCGGCACTTCAGCGAGTCGGAAGCA AGCCAGATCCTGCGCAGCCTCGTGTCGGCCGTGAGCTTCATGCACGAGGAGGCGGGCGTG GTGCACCGCGACCTCAAGCCGGAGAACATCCTGTACGCCGACGACACGCCCGGGGCCCCG GTGAAAATCATCGACTTCGGGTTCGCGCGGTTGCGGCCGCAGAGTCCCGGGGTGCCCATG CAGACGCCCTGCTTCACGCTGCAGTACGCTGCCCCCGAGCTGCTGGCGCAGCAGGGCTAC GACGAGTCCTGCGACCTCTGGAGCCTGGGCGTCATTCTGTACATGATGCTGTCGGGGCAG GTCCCCTTCCAGGGGGCCTCTGGCCAGGGCGGGCAGAGCCAGGCGGCCGAGATCATGTGC AAAATCCGCGAGGGGCGCTTCTCCCTTGACGGGGAGGCCTGGCAGGGTGTATCCGAGGAA GCCAAGGAGCTGGTCCGAGGGCTCCTGACCGTGGACCCCGCCAAGCGGCTGAAGCTCGAG GGACTGCGGGGCAGCTCGTGGCTGCAGGACGGCAGCGCGCGCTCCTCGCCCCCGCTCCGG ACGCCCGACGTGCTCGAGTCCTCTGGGCCCGCAGTGCGCTCGGGTCTCAACGCCACCTTC ATGGCATTCAACCGGGGCAAGCGGGAGGGCTTCTTCCTGAAGAGCGTGGAGAATGCACCC CTGGCCAAGCGGCGGAAGCAGAAGCTGCGGAGCGCCACCGCCTCCCGCCGGGGCTCCCCT GCACCAGCCAACCCGGGCCGAGCCCCCGTCGCCTCCAAAGGGGCCCCCCGCCGAGCCAAC GGCCCCCTGCCCCCCTCCTAA
- Chromosome Location
- 11
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID O75676 UniProtKB Entry Name KS6A4_HUMAN HGNC ID HGNC:10433 - General References
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