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targets (55) enzymes (1)
for drugs
Identification
Name Riboflavin Monophosphate
Accession Number DB03247 (EXPT01458)
Type small molecule
Groups experimental
Description

A coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues. [PubChem]
Structure Thumb
Download: MOL | SDF | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms Not Available
Salts Not Available
Brand names Not Available
Brand mixtures Not Available
Categories
  • Vitamin B Complex
CAS number 146-17-8
Weight Average: 456.3438
Monoisotopic: 456.104614802
Chemical Formula C17H21N4O9P
InChI Key InChIKey=FVTCRASFADXXNN-YRGRVCCFSA-N
InChI
InChI=1S/C17H21N4O9P/c1-7-3-9-10(4-8(7)2)21(15-13(18-9)16(25)20-17(26)19-15)5-11(22)14(24)12(23)6-30-31(27,28)29/h3-4,11-12,14,22-24H,5-6H2,1-2H3,(H,20,25,26)(H2,27,28,29)/t11-,12-,14-/m1/s1
Plain Text
IUPAC Name
{[(2R,3R,4R)-5-{7,8-dimethyl-2,4-dioxo-2H,3H,4H,10H-benzo[g]pteridin-10-yl}-2,3,4-trihydroxypentyl]oxy}phosphonic acid
SMILES
CC1=CC2=C(C=C1C)N(C[C@@H](O)[C@@H](O)[C@H](O)COP(O)(O)=O)C1=NC(=O)NC(=O)C1=N2
Plain Text
Mass Spec Not Available
Taxonomy
Kingdom Not Available
Classes Not Available
Substructures Not Available
Pharmacology
Indication Not Available
Pharmacodynamics Not Available
Mechanism of action Not Available
Absorption Not Available
Volume of distribution Not Available
Protein binding Not Available
Metabolism Not Available
Route of elimination Not Available
Half life Not Available
Clearance Not Available
Toxicity Not Available
Affected organisms Not Available
Pathways Not Available
Pharmacoeconomics
Manufacturers Not Available
Packagers Not Available
Dosage forms Not Available
Prices Not Available
Patents Not Available
Properties
State solid
Experimental Properties Not Available
Predicted Properties
Property Value Source
water solubility 6.68e-01 g/l ALOGPS
logP -0.78 ALOGPS
logP -1.2 ChemAxon
logS -2.8 ALOGPS
pKa (strongest acidic) 1.57 ChemAxon
pKa (strongest basic) 0.68 ChemAxon
physiological charge -3 ChemAxon
hydrogen acceptor count 11 ChemAxon
hydrogen donor count 6 ChemAxon
polar surface area 201.58 ChemAxon
rotatable bond count 7 ChemAxon
refractivity 107.14 ChemAxon
polarizability 42.47 ChemAxon
References
Synthesis Reference Not Available
General Reference Not Available
External Links
Resource Link
KEGG Compound C00061 Link_out
PubChem Compound 5702760 Link_out
PubChem Substance 46507603 Link_out
BindingDB 50151057 Link_out
ChEBI 17621 Link_out
ChEMBL 17621 Link_out
HET FMN Link_out
ATC Codes Not Available
AHFS Codes Not Available
PDB Entries
FDA label Not Available
MSDS Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available
Targets

1. Trimethylamine dehydrogenase

Pharmacological action: unknown

Trimethylamine + H(2)O + electron-transferring flavoprotein = dimethylamine + formaldehyde + reduced electron- transferring flavoprotein

Organism class: bacterial
UniProt ID: P16099 Link_out
Gene: tmd
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

2. Rubredoxin-oxygen oxidoreductase

Pharmacological action: unknown

Catalyzes the four-electron reduction of one oxygen molecule to two water molecules

Organism class: bacterial
UniProt ID: Q9F0J6 Link_out
Gene: roo
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

3. Riboflavin kinase/FMN adenylyltransferase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9WZW1 Link_out
Gene: TM_0857
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

4. Morphinone reductase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q51990 Link_out
Gene: morB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

5. NADPH-flavin oxidoreductase

Pharmacological action: unknown

Involved in bioluminescence. It is a good supplier of reduced flavin mononucleotide (FMNH2) to the bioluminescence reaction

Organism class: bacterial
UniProt ID: Q56691 Link_out
Gene: frp
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

6. Ribosomal protein S6 kinase alpha-4

Pharmacological action: unknown
Organism class: human
UniProt ID: O75676 Link_out
Gene: RPS6KA4
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

7. Phenazine biosynthesis protein phzG

Pharmacological action: unknown

Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule having important roles in virulence, competition and biological control. Probably catalyzes the final step in the conversion of trans-2,3- dihydro-3-hydroxyanthranilic acid (DHHA) to phenazine-1-carboxylic acid (PCA)

Organism class: bacterial
UniProt ID: Q51793 Link_out
Gene: phzG
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

8. Hypothetical protein

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9I4D4 Link_out
Gene: PA1204
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

9. Hydroxyacid oxidase 2

Pharmacological action: unknown
Organism class: human
UniProt ID: Q9NYQ3 Link_out
Gene: HAO2
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

10. Trp repressor binding protein WrbA, putative

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9RYU4 Link_out
Gene: DR_A0214
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

11. Flavodoxin-1

Pharmacological action: unknown

Low-potential electron donor to a number of redox enzymes (Potential). Involved in the reactivation of inactive cob(II)alamin in methionine synthase

Organism class: bacterial
UniProt ID: P61949 Link_out
Gene: fldA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

12. Isopentenyl-diphosphate delta-isomerase

Pharmacological action: unknown

Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)

Organism class: bacterial
UniProt ID: P50740 Link_out
Gene: fni
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

13. NADH dehydrogenase

Pharmacological action: unknown

Can oxidize either NADH or NADPH with a preference for NADH. Can catalyze electron transfer from NADH to various electron acceptors which include, in addition to molecular oxygen, cytochrome c, 2,6 dichlorphenolindophenol, methylene blue, ferricyanide or P-nitroblue tetrazolium

Organism class: bacterial
UniProt ID: Q60049 Link_out
Gene: nox
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

14. FMN-binding protein

Pharmacological action: unknown

Functions as a redox protein with a potential of -325 mV

Organism class: bacterial
UniProt ID: Q46604 Link_out
Gene: DvMF_2023
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

15. Nitroreductase family protein

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q81EW9 Link_out
Gene: BC_1844
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

16. NADPH--cytochrome P450 reductase

Pharmacological action: unknown

This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5

Organism class: human
UniProt ID: P16435 Link_out
Gene: POR Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

17. Phosphopantothenoylcysteine decarboxylase

Pharmacological action: unknown

Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4'- phosphopantotheine

Organism class: human
UniProt ID: Q96CD2 Link_out
Gene: PPCDC
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

18. PhzG

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: O69755 Link_out
Gene: phzG
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

19. Ferredoxin-dependent glutamate synthase 2

Pharmacological action: unknown

2 L-glutamate + 2 oxidized ferredoxin = L- glutamine + 2-oxoglutarate + 2 reduced ferredoxin

Organism class: bacterial
UniProt ID: P55038 Link_out
Gene: gltS
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

20. Pyridoxamine 5'-phosphate oxidase

Pharmacological action: unknown

Oxidizes PNP and PMP into pyridoxal 5'-phosphate (PLP)

Organism class: bacterial
UniProt ID: P0AFI7 Link_out
Gene: pdxH
Protein Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

21. Flavodoxin

Pharmacological action: unknown

Low-potential electron donor to a number of redox enzymes

Organism class: bacterial
UniProt ID: P00322 Link_out
Protein Sequence: FASTA

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

22. Oxygen-insensitive NAD(P)H nitroreductase

Pharmacological action: unknown

Reduction of a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferred. Capable of reducing nitrofurazone, quinones and the anti-tumor agent CB1954 (5- (aziridin-1-yl)-2,4-dinitrobenzamide). The reduction of CB1954 results in the generation of cytotoxic species

Organism class: bacterial
UniProt ID: P38489 Link_out
Gene: nfnB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

23. Chorismate synthase

Pharmacological action: unknown

5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate

Organism class: bacterial
UniProt ID: P0A2Y7 Link_out
Gene: aroC
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

24. 2,4-dienoyl-CoA reductase [NADPH]

Pharmacological action: unknown

Catalyzes the NADP-dependent reduction of 2,4-dienoyl- CoA to yield trans-2- enoyl-CoA

Organism class: bacterial
UniProt ID: P42593 Link_out
Gene: fadH
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

25. Dihydroorotate dehydrogenase A

Pharmacological action: unknown

(S)-dihydroorotate + O(2) = orotate + H(2)O(2)

Organism class: bacterial
UniProt ID: Q53ZE5 Link_out
Gene: pyrDA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

26. Flavin reductase

Pharmacological action: unknown

Catalyzes electron transfer from reduced pyridine nucleotides to flavins as well as methylene blue, pyrroloquinoline quinone, riboflavin, or methemoglobin. Possible role in protecting cells from oxidative damage or in regulating iron metabolism. In the liver, converts biliverdin to bilirubin

Organism class: human
UniProt ID: P30043 Link_out
Gene: BLVRB Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

27. Hydroxyacid oxidase 1

Pharmacological action: unknown

Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids

Organism class: human
UniProt ID: Q9UJM8 Link_out
Gene: HAO1 Link_out
Protein Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

28. Pyridoxine-5'-phosphate oxidase

Pharmacological action: unknown

Oxidizes PNP and PMP into pyridoxal 5'-phosphate (PLP)

Organism class: human
UniProt ID: Q9NVS9 Link_out
Gene: PNPO Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

29. Major NAD(P)H-flavin oxidoreductase

Pharmacological action: unknown

Involved in bioluminescence. It is a good supplier of reduced flavin mononucleotide (FMNH2) to the bioluminescence reaction. Major FMN reductase. It is capable of using both NADH and NADPH as electron donors. As electron acceptor, FMN is the most effective, FAD is considerably effective, and riboflavin is the least effective

Organism class: bacterial
UniProt ID: P46072 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

30. Riboflavin kinase

Pharmacological action: unknown

Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN)

Organism class: human
UniProt ID: Q969G6 Link_out
Gene: RFK Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

31. Oxygen-insensitive NADPH nitroreductase

Pharmacological action: unknown

Reduction of nitroaromatic compounds using NADH. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product. Major component of the oxygen- insensitive nitroreductase activity in E.coli

Organism class: bacterial
UniProt ID: P17117 Link_out
Gene: nfsA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

32. Nitric-oxide synthase, brain

Pharmacological action: unknown

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter

Organism class: human
UniProt ID: P29475 Link_out
Gene: NOS1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

33. Dihydroorotate dehydrogenase

Pharmacological action: unknown

(S)-dihydroorotate + O(2) = orotate + H(2)O(2)

Organism class: bacterial
UniProt ID: P0A7E1 Link_out
Gene: pyrD
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

34. Dihydropyrimidine dehydrogenase [NADP+]

Pharmacological action: unknown

Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil

Organism class: human
UniProt ID: Q12882 Link_out
Gene: DPYD Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

35. Dihydroorotate dehydrogenase, mitochondrial

Pharmacological action: unknown
Organism class: human
UniProt ID: Q02127 Link_out
Gene: DHODH Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

36. Pentaerythritol tetranitrate reductase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: P71278 Link_out
Gene: onr
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

37. FMN-dependent NADH-azoreductase

Pharmacological action: unknown

Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity)

Organism class: bacterial
UniProt ID: P63462 Link_out
Gene: azoR
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

38. Epidermin decarboxylase

Pharmacological action: unknown

Catalyzes the removal of two reducing equivalents (oxidative decarboxylation) from the cysteine residue of the C- terminal meso-lanthionine of epidermin to form a --C==C-- double bond

Organism class: bacterial
UniProt ID: P30197 Link_out
Gene: epiD
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

39. FMN-dependent NADH-azoreductase

Pharmacological action: unknown

Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity. The enzyme can reduce ethyl red and methyl red, but is not able to convert sulfonated azo dyes

Organism class: bacterial
UniProt ID: P41407 Link_out
Gene: azoR
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

40. Chorismate synthase

Pharmacological action: unknown

5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate

Organism class: bacterial
UniProt ID: P56122 Link_out
Gene: aroC
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

41. Flavodoxin

Pharmacological action: unknown

Low-potential electron donor to a number of redox enzymes

Organism class: bacterial
UniProt ID: P0A3D9 Link_out
Gene: isiB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

42. Flavodoxin

Pharmacological action: unknown

Low-potential electron donor to a number of redox enzymes

Organism class: bacterial
UniProt ID: P00323 Link_out
Gene: DVU_2680
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

43. Flavodoxin

Pharmacological action: unknown

Low-potential electron donor to a number of redox enzymes

Organism class: bacterial
UniProt ID: P10340 Link_out
Gene: isiB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

44. Hypothetical protein SMU.260

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q8DW21 Link_out
Gene: SMU_260
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

45. YtnJ

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: O34974 Link_out
Gene: moxC
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

46. Hypothetical protein

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9WXV1 Link_out
Gene: TM_0096
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

47. Protein nrdI

Pharmacological action: unknown

Not known; probably involved in ribonucleotide reductase function

Organism class: bacterial
UniProt ID: P50618 Link_out
Gene: nrdI
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

48. Probable aromatic acid decarboxylase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: P69772 Link_out
Gene: pad1
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

49. L(+)-mandelate dehydrogenase

Pharmacological action: unknown

Reduction of L(+)-mandelate to benzoylformate

Organism class: bacterial
UniProt ID: P20932 Link_out
Gene: mdlB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

50. Hypothetical protein yhdA

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: O07529 Link_out
Gene: azr
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

51. Flavodoxin

Pharmacological action: unknown

Low-potential electron donor to a number of redox enzymes (By similarity)

Organism class: bacterial
UniProt ID: Q9ZK53 Link_out
Gene: fldA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

52. Serine/threonine-protein kinase Sgk1

Pharmacological action: unknown

Protein kinase that plays an important role in cellular stress response. Activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic FOXO3A. Phosphorylates NEDD4L, which leads to its inactivation and to the subsequent activation of various channels and transporters such as ENaC, KCNA3/Kv1.3 or EAAT1. Isoform 2 exhibited a greater effect on cell plasma membrane expression of ENaC and Na(+) transport than isoform 1

Organism class: human
UniProt ID: O00141 Link_out
Gene: SGK1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

53. Oxygen-insensitive NAD(P)H nitroreductase

Pharmacological action: unknown

Reduction of a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferred

Organism class: bacterial
UniProt ID: Q01234 Link_out
Gene: nfnB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

54. Nitric oxide reductase

Pharmacological action: unknown

Has nitric oxide reductase activity in combination with Hrb; probably involved in nitrosative stress protection

Organism class: bacterial
UniProt ID: Q9FDN7 Link_out
Gene: fprA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

55. Isopentenyl-diphosphate delta-isomerase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q746I8 Link_out
Gene: fni
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out
Enzymes

1. NADPH--cytochrome P450 reductase

This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5

UniProt ID: P16435 Link_out
Gene: POR Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out
Comments
Drug created on June 13, 2005 07:24 / Updated on February 08, 2013 16:22