Hyaluronan and proteoglycan link protein 1
Details
- Name
- Hyaluronan and proteoglycan link protein 1
- Synonyms
- Cartilage-link protein
- Cartilage-linking protein 1
- CRTL1
- Proteoglycan link protein
- Gene Name
- HAPLN1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0013369|Hyaluronan and proteoglycan link protein 1 MKSLLLLVLISICWADHLSDNYTLDHDRAIHIQAENGPHLLVEAEQAKVFSHRGGNVTLP CKFYRDPTAFGSGIHKIRIKWTKLTSDYLKEVDVFVSMGYHKKTYGGYQGRVFLKGGSDS DASLVITDLTLEDYGRYKCEVIEGLEDDTVVVALDLQGVVFPYFPRLGRYNLNFHEAQQA CLDQDAVIASFDQLYDAWRGGLDWCNAGWLSDGSVQYPITKPREPCGGQNTVPGVRNYGF WDKDKSRYDVFCFTSNFNGRFYYLIHPTKLTYDEAVQACLNDGAQIAKVGQIFAAWKILG YDRCDAGWLADGSVRYPISRPRRRCSPTEAAVRFVGFPDKKHKLYGVYCFRAYN
- Number of residues
- 354
- Molecular Weight
- 40165.215
- Theoretical pI
- Not Available
- GO Classification
- Functionshyaluronic acid bindingProcessescell adhesion / central nervous system development / extracellular matrix organization / mitophagy in response to mitochondrial depolarization / skeletal system developmentComponentsextracellular region / proteinaceous extracellular matrix
- General Function
- Hyaluronic acid binding
- Specific Function
- Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0013370|Hyaluronan and proteoglycan link protein 1 (HAPLN1) ATGAAGAGTCTACTTCTTCTGGTGCTGATTTCAATCTGCTGGGCTGATCATCTTTCAGAC AACTATACTCTGGATCATGACAGAGCTATTCACATCCAAGCAGAAAATGGCCCCCATCTA CTTGTGGAAGCAGAGCAAGCCAAGGTGTTTTCACACAGAGGTGGCAATGTTACACTGCCA TGTAAATTTTATCGAGACCCTACAGCATTTGGCTCAGGAATCCATAAAATCCGAATTAAG TGGACCAAGCTAACTTCGGATTACCTCAAGGAAGTGGATGTTTTTGTTTCCATGGGATAC CACAAAAAAACCTATGGAGGCTACCAGGGTAGAGTGTTTCTGAAGGGAGGCAGTGATAGT GATGCTTCTCTGGTCATCACAGACCTCACTCTGGAAGATTATGGGAGATATAAGTGTGAG GTGATTGAAGGATTAGAAGATGATACTGTTGTGGTAGCACTGGACTTACAAGGTGTGGTA TTCCCTTACTTTCCACGACTGGGGCGCTACAATCTCAATTTTCACGAGGCGCAGCAGGCG TGTCTGGACCAGGATGCTGTGATCGCCTCCTTCGACCAGCTGTACGACGCCTGGCGGGGC GGGCTGGACTGGTGCAATGCCGGCTGGCTCAGTGATGGCTCTGTGCAATATCCCATCACA AAGCCCAGAGAGCCCTGTGGGGGGCAGAACACAGTGCCCGGAGTCAGGAACTACGGATTT TGGGATAAAGATAAAAGCAGATATGATGTTTTCTGTTTTACATCCAATTTCAATGGCCGT TTTTACTATCTGATCCACCCCACCAAACTGACCTATGATGAAGCGGTGCAAGCTTGTCTC AATGATGGTGCTCAGATTGCAAAAGTGGGCCAGATATTTGCTGCCTGGAAAATTCTCGGA TATGACCGCTGTGATGCGGGCTGGTTGGCGGATGGCAGCGTCCGCTACCCCATCTCTAGG CCAAGAAGGCGCTGCAGTCCTACTGAGGCTGCAGTGCGCTTCGTGGGTTTCCCAGATAAA AAGCATAAGCTGTATGGTGTCTACTGCTTCAGAGCATACAACTGA
- Chromosome Location
- 5
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P10915 UniProtKB Entry Name HPLN1_HUMAN HGNC ID HGNC:2380 - General References
- Dudhia J, Hardingham TE: The primary structure of human cartilage link protein. Nucleic Acids Res. 1990 Mar 11;18(5):1292. [Article]
- Dudhia J, Hardingham TE: The primary structure of human cartilage link protein. Nucleic Acids Res. 1990 Apr 25;18(8):2214. [Article]
- Osborne-Lawrence SL, Sinclair AK, Hicks RC, Lacey SW, Eddy RL Jr, Byers MG, Shows TB, Duby AD: Complete amino acid sequence of human cartilage link protein (CRTL1) deduced from cDNA clones and chromosomal assignment of the gene. Genomics. 1990 Nov;8(3):562-7. [Article]
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