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Identification
NameHyaluronic acid
Accession NumberDB08818
TypeSmall Molecule
GroupsApproved, Vet Approved
DescriptionHyaluronic acid (HA) is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. It is unique among glycosaminoglycans in that it is nonsulfated, forms in the plasma membrane instead of the Golgi, and can be very large, with its molecular weight often reaching the millions. One of the chief components of the extracellular matrix, hyaluronic acid contributes significantly to cell proliferation and migration, and may also be involved in the progression of some malignant tumors.
Structure
Thumb
Synonyms
Hyaluronan
Hyaluronate
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Hyaluronic Acid Micropatch1.14 g/41topicalJunmok International,Inc2015-07-01Not applicableUs
Hylase Woundgel2.5 g/100gtopicalECR Pharmaceuticals Co., Inc.2012-01-06Not applicableUs
Morisusolution.01 g/100mLtopicalKyungnam College Of Information & Technology2011-02-08Not applicableUs
Morisusolution.01 mL/100mLtopicalKit Living Science Of Kyungnam College University Of Information & Technology2011-02-08Not applicableUs
Ramosu Hyaluronic Acid Solution 100liquid100 g/100mLtopicalRa Mo Su2016-02-04Not applicableUs
Wellage Hyaluronic Acid Micro Needlepatch99 g/100gtopicalHugel Pharma Co.,Ltd2014-11-04Not applicableUs
International Brands
NameCompany
AMO VitraxNot Available
AMVISIC PlusNot Available
CystistarNot Available
EuflexxaFerring
HyalartNot Available
HyalganFidia
Hylo-ComodNot Available
LegendNot Available
MonoviscAnika Therapeutics, Inc.
RecosynNot Available
SynviscNot Available
ViscureNot Available
YardelNot Available
Brand mixtures
NameLabellerIngredients
Clapiel Hyalon SerumAus Korea Co., Ltd.
Hyaluronic Acid 60mg and Lidocaine 2% PFUs Compounding, Inc
Salts
Name/CASStructureProperties
Hyaluronate sodium
ThumbNot applicableDBSALT001489
Potassium hyaluronate
31799-91-4
ThumbNot applicableDBSALT001258
Sodium hyaluronate
9067-32-7
ThumbNot applicableDBSALT001259
Categories
UNIIS270N0TRQY
CAS number9004-61-9
WeightAverage: 776.6486
Monoisotopic: 776.233485724
Chemical FormulaC28H44N2O23
InChI KeyKIUKXJAPPMFGSW-MNSSHETKSA-N
InChI
InChI=1S/C28H44N2O23/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45)/t7-,8-,9-,10-,11-,12-,13+,14+,15-,16-,17-,18?,19?,20+,21+,22+,25-,26+,27-,28-/m1/s1
IUPAC Name
(2S,3S,4R,5R,6R)-3-{[(2S,3R,5S,6R)-4-{[(2R,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxyoxan-2-yl]oxy}-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-6-{[(2R,3R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy}-4,5-dihydroxyoxane-2-carboxylic acid
SMILES
CC(=O)N[[email protected]]1[[email protected]](O)O[[email protected]](CO)[C@@H](O)C1O[C@@H]1O[C@@H]([C@@H](O[C@@H]2O[[email protected]](CO)[C@@H](O)C(O[C@@H]3O[C@@H]([C@@H](O)[[email protected]](O)[[email protected]]3O)C(O)=O)[[email protected]]2NC(C)=O)[[email protected]](O)[[email protected]]1O)C(O)=O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as acylaminosugars. These are organic compounds containing a sugar linked to a chain through N-acyl group.
KingdomOrganic compounds
Super ClassOrganooxygen compounds
ClassCarbohydrates and carbohydrate conjugates
Sub ClassAminosaccharides
Direct ParentAcylaminosugars
Alternative Parents
Substituents
  • Oligosaccharide
  • Acylaminosugar
  • Fatty acyl glycoside
  • N-acyl-alpha-hexosamine
  • O-glucuronide
  • 1-o-glucuronide
  • Glucuronic acid or derivatives
  • O-glycosyl compound
  • Glycosyl compound
  • Pyran carboxylic acid
  • Pyran carboxylic acid or derivatives
  • Beta-hydroxy acid
  • Fatty acyl
  • Pyran
  • Oxane
  • Hydroxy acid
  • Dicarboxylic acid or derivatives
  • Acetamide
  • Secondary carboxylic acid amide
  • Secondary alcohol
  • Polyol
  • Hemiacetal
  • Carboxamide group
  • 1,2-diol
  • Oxacycle
  • Organoheterocyclic compound
  • Carboxylic acid
  • Carboxylic acid derivative
  • Carboxylic acid amide
  • Acetal
  • Hydrocarbon derivative
  • Primary alcohol
  • Organonitrogen compound
  • Carbonyl group
  • Alcohol
  • Aliphatic heteromonocyclic compound
Molecular FrameworkAliphatic heteromonocyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationUsed to treat knee pain in patients with joint inflammation (osteoarthritis). It is usually used in patients who have not responded to other treatments such as acetaminophen, exercise, or physical therapy. Hyaluronic acid may also be used in plastic surgery to reduce wrinkles on the face or as a filler in other parts of the body. May be used in ophthalmology to assist in the extraction of cataracts, the implantation of intraocular lenses, corneal transplants, glaucoma filtration, retinal attachment and in the treatment of dry eyes. Finally, hyaluronic acid is also used to coat the bladder lining in treating interstitial cystitis.
PharmacodynamicsHyaluronic acid is similar to a substance that occurs naturally in the joints. It may work by acting as a lubricant and shock absorber in the joint, helping the knee to move smoothly, thereby lessening pain.
Mechanism of actionHyaluronic acid functions as a tissue lubricant and is thought to play an important role in modulating the interactions between adjacent tissues. Hyaluronic acid is a polysaccharide which is distributed widely in the extracellular matrix of connective tissue in man. It forms a viscoelastic solution in water which makes it suitable for aqueous and vitreous humor in ophthalmic surgery. Mechanical protection for tissues (iris, retina) and cell layers (corneal, endothelium, and epithelium) are provided by the high viscosity of the solution. Elasticity of the solution assists in absorbing mechanical stress and providing a protective buffer for tissues. This viscoelasticity enables maintenance of a deep chamber during surgical manipulation since the solution does not flow out of the open anterior chamber. In facilitating wound healing, it is thought that it acts as a protective transport vehicle, taking peptide growth factors and other structural proteins to a site of action. It is then enzymatically degraded and active proteins are released to promote tissue repair. Hyaluronic acid is being used intra-articularly to treat osteoarthritis. Cell receptors that have been identified for hyaluronic acid fall into three main groups: CD44, Receptor for Hyaluronan-mediated motility (RHAMM) and intracellular adhesion molecule-1 (ICAM-1). CD44 mediates cell interaction with hyaluronic acid and the binding of the two functions as an important part in various physiologic events, such as cell aggregation, migration, proliferation and activation; cell-cell and cell-substrate adhesion; endocytosis of hyaluronic acid, which leads to hyaluronic acid catabolism in macrophages; and assembly of petircellular matrices from HA and proteoglycan. CD44 has two important roles in skin, regulation of keratinocyte proliferation in response to extracellular stimuli and the maintenance of local hyaluronic acid homeostasis. ICAM-1 is known mainly as a metabolic cell surface receptor for hyaluronic acid, and this protein may be responsible mainly for the clearance of hyaluronic acid from lymph and blood plasma, which accounts for perhaps most of its whole-body turnover. Ligand binding of this receptor, thus, triggers a highly coordinated cascade of events that includes the formation of an endocytotic vesicle, its fusion with primary lysosomes, enzymatic digestion to monosaccharides, active transmembrane transport of these sugars to cell sap, phosphorylation of GlcNAc and enzymatic deacetylation. ICAM-1 may also serve as a cell adhesion molecule, and the binding of hyaluronic acid to ICAM-1 may contribute to the control of ICAM-1-mediated inflammatory activation.
Related Articles
AbsorptionHyaluronic acid is absorbed and diffuses slowly out of the injection site.
Volume of distributionNot Available
Protein bindingNot Available
Metabolism

Hyaluronic acid is degraded by a family of enzymes called hyaluronidases.

Route of eliminationHyaluronic acid is eliminated via the canal of Schlemm.
Half lifeNot Available
ClearanceNot Available
Toxicity>2400 mg/kg (mouse, oral, sodium salt) >4000 mg/kg (mouse, subcutaneous, sodium salt) 1500 mg/kg (mouse, intraperitoneal, sodium salt)
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal AbsorptionNot AvailableNot Available
Blood Brain BarrierNot AvailableNot Available
Caco-2 permeableNot AvailableNot Available
P-glycoprotein substrateNot AvailableNot Available
P-glycoprotein inhibitor INot AvailableNot Available
P-glycoprotein inhibitor IINot AvailableNot Available
Renal organic cation transporterNot AvailableNot Available
CYP450 2C9 substrateNot AvailableNot Available
CYP450 2D6 substrateNot AvailableNot Available
CYP450 3A4 substrateNot AvailableNot Available
CYP450 1A2 substrateNot AvailableNot Available
CYP450 2C9 inhibitorNot AvailableNot Available
CYP450 2D6 inhibitorNot AvailableNot Available
CYP450 2C19 inhibitorNot AvailableNot Available
CYP450 3A4 inhibitorNot AvailableNot Available
CYP450 inhibitory promiscuityNot AvailableNot Available
Ames testNot AvailableNot Available
CarcinogenicityNot AvailableNot Available
BiodegradationNot AvailableNot Available
Rat acute toxicityNot AvailableNot applicable
hERG inhibition (predictor I)Not AvailableNot Available
hERG inhibition (predictor II)Not AvailableNot Available
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
Creamtopical
Injection, solutionintra-articular
Patchtopical1.14 g/41
Geltopical2.5 g/100g
Solutiontopical.01 g/100mL
Solutiontopical.01 mL/100mL
Liquidtopical100 g/100mL
Patchtopical99 g/100g
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
water solubilityEasily soluble in cold water. Insoluble in organic solvents.Not Available
Predicted Properties
PropertyValueSource
Water Solubility46.6 mg/mLALOGPS
logP-1.8ALOGPS
logP-8.2ChemAxon
logS-1.2ALOGPS
pKa (Strongest Acidic)2.87ChemAxon
pKa (Strongest Basic)-3.9ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count23ChemAxon
Hydrogen Donor Count14ChemAxon
Polar Surface Area399.71 Å2ChemAxon
Rotatable Bond Count12ChemAxon
Refractivity155.1 m3·mol-1ChemAxon
Polarizability70.56 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis Reference

Susan Hockfield, Diane M. Jaworski, “DNA encoding BEHAB, a brain hyaluronan-binding protein, and recombinant expression systems for production of BEHAB polypeptides.” U.S. Patent US5635370, issued June 03, 1997.

US5635370
General ReferencesNot Available
External Links
ATC CodesS01KA01R01AX09S01KA51M09AX01D03AX05
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (19.5 KB)
Interactions
Drug InteractionsNot Available
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
General Function:
Hyalurononglucosaminidase activity
Specific Function:
Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation...
Gene Name:
CD44
Uniprot ID:
P16070
Molecular Weight:
81537.025 Da
Kind
Protein
Organism
Human
Pharmacological action
yes
General Function:
Virus receptor activity
Specific Function:
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.(Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins (PubMed:1968231, PubMed:2538243). Acts as a receptor...
Gene Name:
ICAM1
Uniprot ID:
P05362
Molecular Weight:
57824.785 Da
References
  1. Comper, Wayne D. (1996). Extracellular Matrix (2nd ed.). CRC Press LLC. [ISBN:3718658437 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
General Function:
Hyaluronic acid binding
Specific Function:
Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity.
Gene Name:
HMMR
Uniprot ID:
O75330
Molecular Weight:
84099.845 Da
References
  1. Turley EA: Purification of a hyaluronate-binding protein fraction that modifies cell social behavior. Biochem Biophys Res Commun. 1982 Oct 15;108(3):1016-24. [PubMed:6185115 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
binder
General Function:
Hyaluronic acid binding
Specific Function:
May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.
Gene Name:
NCAN
Uniprot ID:
O14594
Molecular Weight:
143092.14 Da
References
  1. Prange CK, Pennacchio LA, Lieuallen K, Fan W, Lennon GG: Characterization of the human neurocan gene, CSPG3. Gene. 1998 Oct 23;221(2):199-205. [PubMed:9795216 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
binder
General Function:
Hyaluronic acid binding
Specific Function:
May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.
Gene Name:
VCAN
Uniprot ID:
P13611
Molecular Weight:
372816.875 Da
References
  1. Perides G, Lane WS, Andrews D, Dahl D, Bignami A: Isolation and partial characterization of a glial hyaluronate-binding protein. J Biol Chem. 1989 Apr 5;264(10):5981-7. [PubMed:2466833 ]
  2. Bignami A, Lane WS, Andrews D, Dahl D: Structural similarity of hyaluronate binding proteins in brain and cartilage. Brain Res Bull. 1989 Jan;22(1):67-70. [PubMed:2469524 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
binder
General Function:
Transcription factor binding
Specific Function:
Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to t...
Gene Name:
C1QBP
Uniprot ID:
Q07021
Molecular Weight:
31361.935 Da
References
  1. Yadav G, Prasad RL, Jha BK, Rai V, Bhakuni V, Datta K: Evidence for inhibitory interaction of hyaluronan-binding protein 1 (HABP1/p32/gC1qR) with Streptococcus pneumoniae hyaluronidase. J Biol Chem. 2009 Feb 6;284(6):3897-905. doi: 10.1074/jbc.M804246200. Epub 2008 Nov 11. [PubMed:19004836 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
binder
General Function:
Hyaluronic acid binding
Specific Function:
Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.
Gene Name:
HAPLN1
Uniprot ID:
P10915
Molecular Weight:
40165.215 Da
References
  1. Spicer AP, Joo A, Bowling RA Jr: A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links. J Biol Chem. 2003 Jun 6;278(23):21083-91. Epub 2003 Mar 27. [PubMed:12663660 ]
  2. Arming S, Strobl B, Wechselberger C, Kreil G: In vitro mutagenesis of PH-20 hyaluronidase from human sperm. Eur J Biochem. 1997 Aug 1;247(3):810-4. [PubMed:9288901 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
binder
General Function:
Hyaluronic acid binding
Specific Function:
May function in hyaluronic acid binding.
Gene Name:
HAPLN3
Uniprot ID:
Q96S86
Molecular Weight:
40893.995 Da
References
  1. Spicer AP, Joo A, Bowling RA Jr: A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links. J Biol Chem. 2003 Jun 6;278(23):21083-91. Epub 2003 Mar 27. [PubMed:12663660 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
binder
General Function:
Hyaluronic acid binding
Specific Function:
Binds to hyaluronic acid and may be involved in formation of the extracellular matrix.
Gene Name:
HAPLN4
Uniprot ID:
Q86UW8
Molecular Weight:
42801.105 Da
References
  1. Spicer AP, Joo A, Bowling RA Jr: A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links. J Biol Chem. 2003 Jun 6;278(23):21083-91. Epub 2003 Mar 27. [PubMed:12663660 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
binder
General Function:
Serine-type endopeptidase activity
Specific Function:
Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active ...
Gene Name:
HABP2
Uniprot ID:
Q14520
Molecular Weight:
62671.255 Da
References
  1. Choi-Miura NH, Tobe T, Sumiya J, Nakano Y, Sano Y, Mazda T, Tomita M: Purification and characterization of a novel hyaluronan-binding protein (PHBP) from human plasma: it has three EGF, a kringle and a serine protease domain, similar to hepatocyte growth factor activator. J Biochem. 1996 Jun;119(6):1157-65. [PubMed:8827452 ]
  2. Choi-Miura NH, Yoda M, Saito K, Takahashi K, Tomita M: Identification of the substrates for plasma hyaluronan binding protein. Biol Pharm Bull. 2001 Feb;24(2):140-3. [PubMed:11217080 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
binder
General Function:
Hyaluronic acid binding
Specific Function:
Receptor for hyaluronate.
Gene Name:
LAYN
Uniprot ID:
Q6UX15
Molecular Weight:
43108.055 Da
References
  1. Bono P, Rubin K, Higgins JM, Hynes RO: Layilin, a novel integral membrane protein, is a hyaluronan receptor. Mol Biol Cell. 2001 Apr;12(4):891-900. [PubMed:11294894 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
binder
General Function:
Scavenger receptor activity
Specific Function:
Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptid...
Gene Name:
STAB2
Uniprot ID:
Q8WWQ8
Molecular Weight:
276985.63 Da
References
  1. Politz O, Gratchev A, McCourt PA, Schledzewski K, Guillot P, Johansson S, Svineng G, Franke P, Kannicht C, Kzhyshkowska J, Longati P, Velten FW, Johansson S, Goerdt S: Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues. Biochem J. 2002 Feb 15;362(Pt 1):155-64. [PubMed:11829752 ]
  2. Zhou B, McGary CT, Weigel JA, Saxena A, Weigel PH: Purification and molecular identification of the human hyaluronan receptor for endocytosis. Glycobiology. 2003 May;13(5):339-49. Epub 2002 Dec 17. [PubMed:12626425 ]
  3. Harris EN, Kyosseva SV, Weigel JA, Weigel PH: Expression, processing, and glycosaminoglycan binding activity of the recombinant human 315-kDa hyaluronic acid receptor for endocytosis (HARE). J Biol Chem. 2007 Feb 2;282(5):2785-97. Epub 2006 Dec 4. [PubMed:17145755 ]
  4. Harris EN, Weigel JA, Weigel PH: The human hyaluronan receptor for endocytosis (HARE/Stabilin-2) is a systemic clearance receptor for heparin. J Biol Chem. 2008 Jun 20;283(25):17341-50. doi: 10.1074/jbc.M710360200. Epub 2008 Apr 22. [PubMed:18434317 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
binder
General Function:
Hyaluronic acid binding
Specific Function:
Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.
Gene Name:
TNFAIP6
Uniprot ID:
P98066
Molecular Weight:
31203.09 Da
References
  1. Wisniewski HG, Burgess WH, Oppenheim JD, Vilcek J: TSG-6, an arthritis-associated hyaluronan binding protein, forms a stable complex with the serum protein inter-alpha-inhibitor. Biochemistry. 1994 Jun 14;33(23):7423-9. [PubMed:7516184 ]
  2. Lee TH, Wisniewski HG, Vilcek J: A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44. J Cell Biol. 1992 Jan;116(2):545-57. [PubMed:1730767 ]
  3. Kohda D, Morton CJ, Parkar AA, Hatanaka H, Inagaki FM, Campbell ID, Day AJ: Solution structure of the link module: a hyaluronan-binding domain involved in extracellular matrix stability and cell migration. Cell. 1996 Sep 6;86(5):767-75. [PubMed:8797823 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
binder
General Function:
Hyaluronic acid binding
Specific Function:
Chondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix; may participate in the maturation and maintenance of the light-sensitive photoreceptor outer segment. Binds heparin.
Gene Name:
IMPG2
Uniprot ID:
Q9BZV3
Molecular Weight:
138619.39 Da
References
  1. Acharya S, Foletta VC, Lee JW, Rayborn ME, Rodriguez IR, Young WS 3rd, Hollyfield JG: SPACRCAN, a novel human interphotoreceptor matrix hyaluronan-binding proteoglycan synthesized by photoreceptors and pinealocytes. J Biol Chem. 2000 Mar 10;275(10):6945-55. [PubMed:10702256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
binder
General Function:
Not Available
Specific Function:
May be involved in nuclear functions such as the remodeling of chromatin and the regulation of transcription.
Gene Name:
HABP4
Uniprot ID:
Q5JVS0
Molecular Weight:
45785.09 Da
References
  1. Huang L, Grammatikakis N, Yoneda M, Banerjee SD, Toole BP: Molecular characterization of a novel intracellular hyaluronan-binding protein. J Biol Chem. 2000 Sep 22;275(38):29829-39. [PubMed:10887182 ]
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Drug created on February 23, 2012 11:15 / Updated on August 17, 2016 12:24