Integrin alpha-4
Details
- Name
- Integrin alpha-4
- Synonyms
- CD49 antigen-like family member D
- CD49D
- Integrin alpha-IV
- VLA-4 subunit alpha
- Gene Name
- ITGA4
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0037051|Integrin alpha-4 MAWEARREPGPRRAAVRETVMLLLCLGVPTGRPYNVDTESALLYQGPHNTLFGYSVVLHS HGANRWLLVGAPTANWLANASVINPGAIYRCRIGKNPGQTCEQLQLGSPNGEPCGKTCLE ERDNQWLGVTLSRQPGENGSIVTCGHRWKNIFYIKNENKLPTGGCYGVPPDLRTELSKRI APCYQDYVKKFGENFASCQAGISSFYTKDLIVMGAPGSSYWTGSLFVYNITTNKYKAFLD KQNQVKFGSYLGYSVGAGHFRSQHTTEVVGGAPQHEQIGKAYIFSIDEKELNILHEMKGK KLGSYFGASVCAVDLNADGFSDLLVGAPMQSTIREEGRVFVYINSGSGAVMNAMETNLVG SDKYAARFGESIVNLGDIDNDGFEDVAIGAPQEDDLQGAIYIYNGRADGISSTFSQRIEG LQISKSLSMFGQSISGQIDADNNGYVDVAVGAFRSDSAVLLRTRPVVIVDASLSHPESVN RTKFDCVENGWPSVCIDLTLCFSYKGKEVPGYIVLFYNMSLDVNRKAESPPRFYFSSNGT SDVITGSIQVSSREANCRTHQAFMRKDVRDILTPIQIEAAYHLGPHVISKRSTEEFPPLQ PILQQKKEKDIMKKTINFARFCAHENCSADLQVSAKIGFLKPHENKTYLAVGSMKTLMLN VSLFNAGDDAYETTLHVKLPVGLYFIKILELEEKQINCEVTDNSGVVQLDCSIGYIYVDH LSRIDISFLLDVSSLSRAEEDLSITVHATCENEEEMDNLKHSRVTVAIPLKYEVKLTVHG FVNPTSFVYGSNDENEPETCMVEKMNLTFHVINTGNSMAPNVSVEIMVPNSFSPQTDKLF NILDVQTTTGECHFENYQRVCALEQQKSAMQTLKGIVRFLSKTDKRLLYCIKADPHCLNF LCNFGKMESGKEASVHIQLEGRPSILEMDETSALKFEIRATGFPEPNPRVIELNKDENVA HVLLEGLHHQRPKRYFTIVIISSSLLLGLIVLLLISYVMWKAGFFKRQYKSILQEENRRD SWSYINSKSNDD
- Number of residues
- 1032
- Molecular Weight
- 114898.745
- Theoretical pI
- 6.32
- GO Classification
- Functionscell adhesion molecule binding / metal ion bindingProcessesB cell differentiation / blood coagulation / blood vessel remodeling / cell-matrix adhesion / cell-matrix adhesion involved in ameboidal cell migration / cellular response to cytokine stimulus / chorio-allantoic fusion / diapedesis / endodermal cell differentiation / extracellular matrix organization / face development / heart development / heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules / heterotypic cell-cell adhesion / import into cell / integrin-mediated signaling pathway / leukocyte cell-cell adhesion / leukocyte migration / leukocyte tethering or rolling / negative regulation of protein homodimerization activity / positive regulation of leukocyte tethering or rolling / positive regulation of T cell migration / receptor clustering / regulation of immune response / substrate adhesion-dependent cell spreading / T cell migrationComponentscell surface / cell-cell junction / external side of plasma membrane / extracellular exosome / focal adhesion / integrin alpha4-beta7 complex / membrane / plasma membrane
- General Function
- Metal ion binding
- Specific Function
- Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.
- Pfam Domain Function
- Transmembrane Regions
- 978-1001
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0010411|Integrin alpha-4 (ITGA4) ATGGCTTGGGAAGCGAGGCGCGAACCCGGCCCCCGAAGGGCCGCCGTCCGGGAGACGGTG ATGCTGTTGCTGTGCCTGGGGGTCCCGACCGGCCGCCCCTACAACGTGGACACTGAGAGC GCGCTGCTTTACCAGGGCCCCCACAACACGCTGTTCGGCTACTCGGTCGTGCTGCACAGC CACGGGGCGAACCGATGGCTCCTAGTGGGTGCGCCCACTGCCAACTGGCTCGCCAACGCT TCAGTGATCAATCCCGGGGCGATTTACAGATGCAGGATCGGAAAGAATCCCGGCCAGACG TGCGAACAGCTCCAGCTGGGTAGCCCTAATGGAGAACCTTGTGGAAAGACTTGTTTGGAA GAGAGAGACAATCAGTGGTTGGGGGTCACACTTTCCAGACAGCCAGGAGAAAATGGATCC ATCGTGACTTGTGGGCATAGATGGAAAAATATATTTTACATAAAGAATGAAAATAAGCTC CCCACTGGTGGTTGCTATGGAGTGCCCCCTGATTTACGAACAGAACTGAGTAAAAGAATA GCTCCGTGTTATCAAGATTATGTGAAAAAATTTGGAGAAAATTTTGCATCATGTCAAGCT GGAATATCCAGTTTTTACACAAAGGATTTAATTGTGATGGGGGCCCCAGGATCATCTTAC TGGACTGGCTCTCTTTTTGTCTACAATATAACTACAAATAAATACAAGGCTTTTTTAGAC AAACAAAATCAAGTAAAATTTGGAAGTTATTTAGGATATTCAGTCGGAGCTGGTCATTTT CGGAGCCAGCATACTACCGAAGTAGTCGGAGGAGCTCCTCAACATGAGCAGATTGGTAAG GCATATATATTCAGCATTGATGAAAAAGAACTAAATATCTTACATGAAATGAAAGGTAAA AAGCTTGGATCGTACTTTGGAGCTTCTGTCTGTGCTGTGGACCTCAATGCAGATGGCTTC TCAGATCTGCTCGTGGGAGCACCCATGCAGAGCACCATCAGAGAGGAAGGAAGAGTGTTT GTGTACATCAACTCTGGCTCGGGAGCAGTAATGAATGCAATGGAAACAAACCTCGTTGGA AGTGACAAATATGCTGCAAGATTTGGGGAATCTATAGTTAATCTTGGCGACATTGACAAT GATGGCTTTGAAGATGTTGCTATCGGAGCTCCACAAGAAGATGACTTGCAAGGTGCTATT TATATTTACAATGGCCGTGCAGATGGGATCTCGTCAACCTTCTCACAGAGAATTGAAGGA CTTCAGATCAGCAAATCGTTAAGTATGTTTGGACAGTCTATATCAGGACAAATTGATGCA GATAATAATGGCTATGTAGATGTAGCAGTTGGTGCTTTTCGGTCTGATTCTGCTGTCTTG CTAAGGACAAGACCTGTAGTAATTGTTGACGCTTCTTTAAGCCACCCTGAGTCAGTAAAT AGAACGAAATTTGACTGTGTTGAAAATGGATGGCCTTCTGTGTGCATAGATCTAACACTT TGTTTCTCATATAAGGGCAAGGAAGTTCCAGGTTACATTGTTTTGTTTTATAACATGAGT TTGGATGTGAACAGAAAGGCAGAGTCTCCACCAAGATTCTATTTCTCTTCTAATGGAACT TCTGACGTGATTACAGGAAGCATACAGGTGTCCAGCAGAGAAGCTAACTGTAGAACACAT CAAGCATTTATGCGGAAAGATGTGCGGGACATCCTCACCCCAATTCAGATTGAAGCTGCT TACCACCTTGGTCCTCATGTCATCAGTAAACGAAGTACAGAGGAATTCCCACCACTTCAG CCAATTCTTCAGCAGAAGAAAGAAAAAGACATAATGAAAAAAACAATAAACTTTGCAAGG TTTTGTGCCCATGAAAATTGTTCTGCTGATTTACAGGTTTCTGCAAAGATTGGGTTTTTG AAGCCCCATGAAAATAAAACATATCTTGCTGTTGGGAGTATGAAGACATTGATGTTGAAT GTGTCCTTGTTTAATGCTGGAGATGATGCATATGAAACGACTCTACATGTCAAACTACCC GTGGGTCTTTATTTCATTAAGATTTTAGAGCTGGAAGAGAAGCAAATAAACTGTGAAGTC ACAGATAACTCTGGCGTGGTACAACTTGACTGCAGTATTGGCTATATATATGTAGATCAT CTCTCAAGGATAGATATTAGCTTTCTCCTGGATGTGAGCTCACTCAGCAGAGCGGAAGAG GACCTCAGTATCACAGTGCATGCTACCTGTGAAAATGAAGAGGAAATGGACAATCTAAAG CACAGCAGAGTGACTGTAGCAATACCTTTAAAATATGAGGTTAAGCTGACTGTTCATGGG TTTGTAAACCCAACTTCATTTGTGTATGGATCAAATGATGAAAATGAGCCTGAAACGTGC ATGGTGGAGAAAATGAACTTAACTTTCCATGTTATCAACACTGGCAATAGTATGGCTCCC AATGTTAGTGTGGAAATAATGGTACCAAATTCTTTTAGCCCCCAAACTGATAAGCTGTTC AACATTTTGGATGTCCAGACTACTACTGGAGAATGCCACTTTGAAAATTATCAAAGAGTG TGTGCATTAGAGCAGCAAAAGAGTGCAATGCAGACCTTGAAAGGCATAGTCCGGTTCTTG TCCAAGACTGATAAGAGGCTATTGTACTGCATAAAAGCTGATCCACATTGTTTAAATTTC TTGTGTAATTTTGGGAAAATGGAAAGTGGAAAAGAAGCCAGTGTTCATATCCAACTGGAA GGCCGGCCATCCATTTTAGAAATGGATGAGACTTCAGCACTCAAGTTTGAAATAAGAGCA ACAGGTTTTCCAGAGCCAAATCCAAGAGTAATTGAACTAAACAAGGATGAGAATGTTGCG CATGTTCTACTGGAAGGACTACATCATCAAAGACCCAAACGTTATTTCACCATAGTGATT ATTTCAAGTAGCTTGCTACTTGGACTTATTGTACTTCTGTTGATCTCATATGTTATGTGG AAGGCTGGCTTCTTTAAAAGACAATACAAATCTATCCTACAAGAAGAAAACAGAAGAGAC AGTTGGAGTTATATCAACAGTAAAAGCAATGATGATTAA
- Chromosome Location
- 2
- Locus
- 2q31.3
- External Identifiers
Resource Link UniProtKB ID P13612 UniProtKB Entry Name ITA4_HUMAN GenBank Protein ID 33946 GenBank Gene ID X16983 GenAtlas ID ITGA4 HGNC ID HGNC:6140 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00108 Natalizumab approved, investigational yes antibody Details DB04997 ATL1102 investigational unknown Details DB05092 CDP323 investigational unknown Details DB05122 R1295 investigational unknown Details DB05468 R411 investigational unknown Details DB06822 Tinzaparin approved unknown inhibitor Details DB09033 Vedolizumab approved yes antibody Details DB15791 MK-0668 experimental unknown Details