Oxytocin receptor
Details
- Name
- Oxytocin receptor
- Synonyms
- OT-R
- Gene Name
- OXTR
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0010596|Oxytocin receptor MEGALAANWSAEAANASAAPPGAEGNRTAGPPRRNEALARVEVAVLCLILLLALSGNACV LLALRTTRQKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQV VGMFASTYLLLLMSLDRCLAICQPLRSLRRRTDRLAVLATWLGCLVASAPQVHIFSLREV ADGVFDCWAVFIQPWGPKAYITWITLAVYIVPVIVLAACYGLISFKIWQNLRLKTAAAAA AEAPEGAAAGDGGRVALARVSSVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVW DANAPKEASAFIIVMLLASLNSCCNPWIYMLFTGHLFHELVQRFLCCSASYLKGRRLGET SASKKSNSSSFVLSHRSSSQRSCSQPSTA
- Number of residues
- 389
- Molecular Weight
- 42770.99
- Theoretical pI
- 9.88
- GO Classification
- Functionsoxytocin receptor activity / peptide binding / peptide hormone binding / vasopressin receptor activityProcessescell surface receptor signaling pathway / cellular response to hormone stimulus / digestive tract development / eating behavior / ERK1 and ERK2 cascade / estrous cycle / female pregnancy / G-protein coupled receptor signaling pathway / heart development / lactation / maternal behavior / maternal process involved in parturition / memory / muscle contraction / negative regulation of gastric acid secretion / positive regulation of blood pressure / positive regulation of cytosolic calcium ion concentration / positive regulation of norepinephrine secretion / positive regulation of penile erection / positive regulation of synapse assembly / positive regulation of synaptic transmission, GABAergic / positive regulation of synaptic transmission, glutamatergic / positive regulation of uterine smooth muscle contraction / positive regulation of vasoconstriction / regulation of systemic arterial blood pressure by vasopressin / response to amphetamine / response to anoxia / response to cocaine / response to cytokine / response to drug / response to estradiol / response to peptide / response to peptide hormone / response to progesterone / sleep / social behavior / sperm ejaculation / suckling behavior / telencephalon developmentComponentsapical plasma membrane / cell-cell adherens junction / cytosol / integral component of plasma membrane / microvillus / plasma membrane
- General Function
- Vasopressin receptor activity
- Specific Function
- Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
- Pfam Domain Function
- 7tm_1 (PF00001)
- Transmembrane Regions
- 39-63 75-97 114-135 155-175 203-225 276-294 310-332
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0010597|Oxytocin receptor (OXTR) ATGGAGGGCGCGCTCGCAGCCAACTGGAGCGCCGAGGCAGCCAACGCCAGCGCCGCGCCG CCGGGGGCCGAGGGCAACCGCACCGCCGGACCCCCGCGGCGCAACGAGGCCCTGGCGCGC GTGGAGGTGGCGGTGCTGTGTCTCATCCTGCTCCTGGCGCTGAGCGGGAACGCGTGTGTG CTGCTGGCGCTGCGCACCACACGCCAGAAGCACTCGCGCCTCTTCTTCTTCATGAAGCAC CTAAGCATCGCCGACCTGGTGGTGGCAGTGTTTCAGGTGCTGCCGCAGTTGCTGTGGGAC ATCACCTTCCGCTTCTACGGGCCCGACCTGCTGTGCCGCCTGGTCAAGTACTTGCAGGTG GTGGGCATGTTCGCCTCCACCTACCTGCTGCTGCTCATGTCCCTGGACCGCTGCCTGGCC ATCTGCCAGCCGCTGCGCTCGCTGCGCCGCCGCACCGACCGCCTGGCAGTGCTCGCCACG TGGCTCGGCTGCCTGGTGGCCAGCGCGCCGCAGGTGCACATCTTCTCTCTGCGCGAGGTG GCTGACGGCGTCTTCGACTGCTGGGCCGTCTTCATCCAGCCCTGGGGACCCAAGGCCTAC ATCACATGGATCACGCTAGCTGTCTACATCGTGCCGGTCATCGTGCTCGCTGCCTGCTAC GGCCTTATCAGCTTCAAGATCTGGCAGAACTTGCGGCTCAAGACCGCTGCAGCGGCGGCG GCCGAGGCGCCAGAGGGCGCGGCGGCTGGCGATGGGGGGCGCGTGGCCCTGGCGCGTGTC AGCAGCGTCAAGCTCATCTCCAAGGCCAAGATCCGCACGGTCAAGATGACTTTCATCATC GTGCTGGCCTTCATCGTGTGCTGGACGCCTTTCTTCTTCGTGCAGATGTGGAGCGTCTGG GATGCCAACGCGCCCAAGGAAGCCTCGGCCTTCATCATCGTCATGCTCCTGGCCAGCCTC AACAGCTGCTGCAACCCCTGGATCTACATGCTGTTCACGGGCCACCTCTTCCACGAACTC GTGCAGCGCTTCCTGTGCTGCTCCGCCAGCTACCTGAAGGGCAGACGCCTGGGAGAGACG AGTGCCAGCAAAAAGAGCAACTCGTCCTCCTTTGTCCTGAGCCATCGCAGCTCCAGCCAG AGGAGCTGCTCCCAGCCATCCACGGCGTGA
- Chromosome Location
- 3
- Locus
- 3p25
- External Identifiers
Resource Link UniProtKB ID P30559 UniProtKB Entry Name OXYR_HUMAN GenBank Protein ID 34765 GenBank Gene ID X64878 GenAtlas ID OXTR HGNC ID HGNC:8529 - General References
- Kimura T, Tanizawa O, Mori K, Brownstein MJ, Okayama H: Structure and expression of a human oxytocin receptor. Nature. 1992 Apr 9;356(6369):526-9. [Article]
- Inoue T, Kimura T, Azuma C, Inazawa J, Takemura M, Kikuchi T, Kubota Y, Ogita K, Saji F: Structural organization of the human oxytocin receptor gene. J Biol Chem. 1994 Dec 23;269(51):32451-6. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB01282 Carbetocin approved, investigational yes agonist Details DB00107 Oxytocin approved, vet_approved yes agonist Details DB13929 Relcovaptan investigational unknown antagonist Details DB09059 Atosiban approved, investigational yes antagonist Details DB00067 Vasopressin approved yes agonist Details