Peptide deformylase
Details
- Name
- Peptide deformylase
- Synonyms
- 3.5.1.88
- Polypeptide deformylase
- Gene Name
- def
- Organism
- Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
- Amino acid sequence
>lcl|BSEQ0019381|Peptide deformylase MYRIRVFGDPVLRKRAKPVTKFDENLKKTIERMIETMYHYDGVGLAAPQVGISQRFFVMD VGNGPVAVINPEILEIDPETEVAEEGCLSFPEIFVEIERSKRIKVKYQNTRGEYVEEELE GYAARVFQHEFDHLNGVLIIDRISPAKRLLLRKKLMDIARTVKR
- Number of residues
- 164
- Molecular Weight
- 19023.965
- Theoretical pI
- 8.43
- GO Classification
- Functionsiron ion binding / peptide deformylase activityProcessestranslation
- General Function
- Peptide deformylase activity
- Specific Function
- Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).
- Pfam Domain Function
- Pep_deformylase (PF01327)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0019382|Peptide deformylase (def) ATGTACAGAATAAGAGTCTTTGGAGATCCCGTCTTGAGAAAGAGGGCAAAACCCGTTACA AAGTTCGACGAGAACCTGAAAAAGACCATAGAAAGAATGATAGAGACGATGTATCACTAC GACGGTGTGGGACTCGCGGCACCGCAGGTTGGAATATCTCAGAGGTTCTTCGTCATGGAC GTTGGAAATGGTCCGGTTGCCGTGATAAATCCGGAGATTCTTGAAATCGATCCAGAAACT GAAGTAGCAGAAGAGGGGTGCCTCAGCTTTCCCGAGATCTTCGTCGAGATAGAAAGGAGC AAAAGAATAAAGGTCAAATACCAGAACACAAGGGGAGAATACGTGGAAGAAGAACTGGAA GGTTACGCTGCAAGGGTTTTTCAGCACGAGTTCGATCATCTGAACGGAGTTTTGATCATC GATCGAATCAGTCCAGCAAAGCGCCTTTTGCTCAGAAAGAAACTCATGGACATAGCAAGA ACCGTTAAGAGATGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P96113 UniProtKB Entry Name DEF_THEMA GenBank Gene ID Y10306 - General References
- Mazel D, Coic E, Blanchard S, Saurin W, Marliere P: A survey of polypeptide deformylase function throughout the eubacterial lineage. J Mol Biol. 1997 Mar 14;266(5):939-49. [Article]
- Nelson KE, Clayton RA, Gill SR, Gwinn ML, Dodson RJ, Haft DH, Hickey EK, Peterson JD, Nelson WC, Ketchum KA, McDonald L, Utterback TR, Malek JA, Linher KD, Garrett MM, Stewart AM, Cotton MD, Pratt MS, Phillips CA, Richardson D, Heidelberg J, Sutton GG, Fleischmann RD, Eisen JA, White O, Salzberg SL, Smith HO, Venter JC, Fraser CM: Evidence for lateral gene transfer between Archaea and bacteria from genome sequence of Thermotoga maritima. Nature. 1999 May 27;399(6734):323-9. [Article]