Centromere-associated protein E

Details

Name
Centromere-associated protein E
Synonyms
  • CENP-E
  • Centromere protein E
  • Kinesin-related protein CENPE
Gene Name
CENPE
Organism
Humans
Amino acid sequence
>lcl|BSEQ0006699|Centromere-associated protein E
MAEEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTK
NVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIFQKIKKF
PDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSEMALK
WITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDLAGSE
RAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNA
KTRIICTITPVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLE
EVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRR
VTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLS
EIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEAL
ERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDS
QKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELAT
TYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEG
KITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKL
FSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEEN
ERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRD
STLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNI
DTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQD
LEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMT
IENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQ
QQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITK
ERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSE
KTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDS
TTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQ
ESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSV
AKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNL
SEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAK
DSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKM
KESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEE
MRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKL
RGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEK
TDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQS
LTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDL
EIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKEL
QLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKE
RDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRI
KELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQ
RCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCD
VPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRF
DIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNE
KLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHK
ESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDL
KMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTD
PQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHL
SNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQDPVPKESP
KSCFFDSRSKSLPSPHPVRYFDNSSLGLCPEVQNAGAESVDSQPGPWHASSGKDVPECKT
Q
Number of residues
2701
Molecular Weight
316413.1
Theoretical pI
5.36
GO Classification
Functions
ATP binding / ATPase activity / kinetochore binding / microtubule motor activity
Processes
antigen processing and presentation of exogenous peptide antigen via MHC class II / attachment of mitotic spindle microtubules to kinetochore / blood coagulation / cell division / chromosome segregation / kinetochore assembly / microtubule-based movement / mitotic cell cycle / mitotic chromosome movement towards spindle pole / mitotic metaphase plate congression / multicellular organismal development / positive regulation of protein kinase activity / regulation of mitotic metaphase/anaphase transition / small GTPase mediated signal transduction
Components
chromosome / chromosome, centromeric region / condensed chromosome kinetochore / condensed chromosome, centromeric region / cytoplasm / cytosol / kinesin complex / kinetochore / membrane / microtubule / microtubule cytoskeleton / midbody / mitotic spindle midzone / nucleus
General Function
Microtubule motor activity
Specific Function
Essential for the maintenance of chromosomal stability through efficient stabilization of microtubule capture at kinetochores. Plays a key role in the movement of chromosomes toward the metaphase plate during mitosis. Is a slow plus end-directed motor whose activity is essential for metaphase chromosome alignment. Couples chromosome position to microtubule depolymerizing activity. The highly processive microtubule-dependent motor activity of CENPE serves to power chromosome congression and provides a flexible, motile tether linking kinetochores to dynamic spindle microtubules. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss. Required for the efficient recruitment of BUBR1, MAD1 and MAD2 to attached and newly unattached kinetochores. Stimulates mammalian BUBR1 kinase activity. Accumulates just before mitosis at the G2 phase of the cell cycle.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Chromosome
Gene sequence
>lcl|BSEQ0012404|Centromere-associated protein E (CENPE)
ATGGCGGAGGAAGGAGCCGTGGCCGTCTGCGTGCGAGTGCGGCCGCTGAACAGCAGAGAA
GAATCACTTGGAGAAACTGCCCAAGTTTACTGGAAAACTGACAATAATGTCATTTATCAA
GTTGATGGAAGTAAATCCTTCAATTTTGATCGTGTCTTTCATGGTAATGAAACTACCAAA
AATGTGTATGAAGAAATAGCAGCACCAATCATCGATTCTGCCATACAAGGCTACAATGGT
ACTATATTTGCCTATGGACAGACTGCTTCAGGAAAAACATATACCATGATGGGTTCAGAA
GATCATTTGGGAGTTATACCCAGGGCAATTCATGACATTTTCCAAAAAATTAAGAAGTTT
CCTGATAGGGAATTTCTCTTACGTGTATCTTACATGGAAATATACAATGAAACCATTACA
GATTTACTCTGTGGCACTCAAAAAATGAAACCTTTAATTATTCGAGAAGATGTCAATAGG
AATGTGTATGTTGCTGATCTCACAGAAGAAGTTGTATATACATCAGAAATGGCTTTGAAA
TGGATTACAAAGGGAGAAAAGAGCAGGCATTATGGAGAAACAAAAATGAATCAAAGAAGC
AGTCGTTCTCATACCATCTTTAGGATGATTTTGGAAAGCAGAGAGAAGGGTGAACCTTCT
AATTGTGAAGGATCTGTTAAGGTATCCCATTTGAATTTGGTTGATCTTGCAGGCAGTGAA
AGAGCTGCTCAAACAGGCGCTGCAGGTGTGCGGCTCAAGGAAGGCTGTAATATAAATCGA
AGCTTATTTATTTTGGGACAAGTGATCAAGAAACTTAGTGATGGACAAGTTGGTGGTTTC
ATAAATTATCGAGATAGCAAGTTAACACGAATTCTCCAGAATTCCTTGGGAGGAAATGCA
AAGACACGTATTATCTGCACAATTACTCCAGTATCTTTTGATGAAACACTTACTGCTCTC
CAGTTTGCCAGTACTGCTAAATATATGAAGAATACTCCTTATGTTAATGAGGTATCAACT
GATGAAGCTCTCCTGAAAAGGTATAGAAAAGAAATAATGGATCTTAAAAAACAATTAGAG
GAGGTTTCTTTAGAGACGCGGGCTCAGGCAATGGAAAAAGACCAATTGGCCCAACTTTTG
GAAGAAAAAGATTTGCTTCAGAAAGTACAGAATGAGAAAATTGAAAACTTAACACGGATG
CTGGTGACCTCTTCTTCCCTCACGTTGCAACAGGAATTAAAGGCTAAAAGAAAACGAAGA
GTTACTTGGTGCCTTGGCAAAATTAACAAAATGAAGAACTCAAACTATGCAGATCAATTT
AATATACCAACAAATATAACAACAAAAACACATAAGCTTTCTATAAATTTATTACGAGAA
ATTGATGAATCTGTCTGTTCAGAGTCTGATGTTTTCAGTAACACTCTTGATACATTAAGT
GAGATAGAATGGAATCCAGCAACAAAGCTACTAAATCAGGAGAATATAGAAAGTGAGTTG
AACTCACTTCGTGCTGACTATGATAATCTGGTATTAGACTATGAACAACTACGAACAGAA
AAAGAAGAAATGGAATTGAAATTAAAAGAAAAGAATGATTTGGATGAATTTGAGGCTCTA
GAAAGAAAAACTAAAAAAGATCAAGAGAATGAACTCAGTTCAAAAGTAGAGCTGCTTAGA
GAAAAGGAAGACCAGATTAAGAAGCTACAGGAATACATAGACTCTCAAAAGCTAGAAAAT
ATAAAAATGGACTTGTCATACTCATTGGAAAGCATTGAAGACCCAAAACAAATGAAGCAG
ACTCTGTTTGATGCTGAAACTGTAGCCCTTGATGCCAAGAGAGAATCAGCCTTTCTTAGA
AGTGAAAATCTGGAGCTGAAGGAGAAAATGAAAGAACTTGCAACTACATACAAGCAAATG
GAAAATGATATTCAGTTATATCAAAGCCAGTTGGAGGCAAAAAAGAAAATGCAAGTTGAT
CTGGAGAAAGAATTACAATCTGCTTTTAATGAGATAACAAAACTCACCTCCCTTATAGAT
GGCAAAGTTCCAAAAGATTTGCTCTGTAATTTGGAATTGGAAGGAAAGATTACTGATCTT
CAGAAAGAACTAAATAAAGAAGTTGAAGAAAATGAAGCTTTGCGGGAAGAAGTCATTTTG
CTTTCAGAATTGAAATCTTTACCTTCTGAAGTAGAAAGGCTGAGGAAAGAGATACAAGAC
AAATCTGAAGAGCTCCATATAATAACATCAGAAAAAGATAAATTGTTTTCTGAAGTAGTT
CATAAGGAGAGTAGAGTTCAAGGTTTACTTGAAGAAATTGGGAAAACAAAAGATGACCTA
GCAACTACACAGTCGAATTATAAAAGCACTGATCAAGAATTCCAAAATTTCAAAACCCTT
CATATGGACTTTGAGCAAAAGTATAAGATGGTCCTTGAGGAGAATGAGAGAATGAATCAG
GAAATAGTTAATCTCTCTAAAGAAGCCCAAAAATTTGATTCGAGTTTGGGTGCTTTGAAG
ACCGAGCTTTCTTACAAGACCCAAGAACTTCAGGAGAAAACACGTGAGGTTCAAGAAAGA
CTAAATGAGATGGAACAGCTGAAGGAACAATTAGAAAATAGAGATTCTACGCTGCAAACT
GTAGAAAGGGAGAAAACACTGATTACTGAGAAACTGCAGCAAACTTTAGAAGAAGTAAAA
ACTTTAACTCAAGAAAAAGATGATCTAAAACAACTCCAAGAAAGCTTGCAAATTGAGAGG
GACCAACTCAAAAGTGATATTCACGATACTGTTAACATGAATATAGATACTCAAGAACAA
TTACGAAATGCTCTTGAGTCTCTGAAACAACATCAAGAAACAATTAATACACTAAAATCG
AAAATTTCTGAGGAAGTTTCCAGGAATTTGCATATGGAGGAAAATACAGGAGAAACTAAA
GATGAATTTCAGCAAAAGATGGTTGGCATAGATAAAAAACAGGATTTGGAAGCTAAAAAT
ACCCAAACACTAACTGCAGATGTTAAGGATAATGAGATAATTGAGCAACAAAGGAAGATA
TTTTCTTTAATACAGGAGAAAAATGAACTCCAACAAATGTTAGAGAGTGTTATAGCAGAA
AAGGAACAATTGAAGACTGACCTAAAGGAAAATATTGAAATGACCATTGAAAACCAGGAA
GAATTAAGACTTCTTGGGGATGAACTTAAAAAGCAACAAGAGATAGTTGCACAAGAAAAG
AACCATGCCATAAAGAAAGAAGGAGAGCTTTCTAGGACCTGTGACAGACTGGCAGAAGTT
GAAGAAAAACTAAAGGAAAAGAGCCAGCAACTCCAAGAAAAACAGCAACAACTTCTTAAT
GTACAAGAAGAGATGAGTGAGATGCAGAAAAAGATTAATGAAATAGAGAATTTAAAGAAT
GAATTAAAGAACAAAGAATTGACATTGGAACATATGGAAACAGAGAGGCTTGAGTTGGCT
CAGAAACTTAATGAAAATTATGAGGAAGTGAAATCTATAACCAAAGAAAGAAAAGTTCTA
AAGGAATTACAGAAGTCATTTGAAACAGAGAGAGACCACCTTAGAGGATATATAAGAGAA
ATTGAAGCTACAGGCCTACAAACCAAAGAAGAACTAAAAATTGCTCATATTCACCTAAAA
GAACACCAAGAAACTATTGATGAACTAAGAAGAAGCGTATCTGAGAAGACAGCTCAAATA
ATAAATACTCAGGACTTAGAAAAATCCCATACCAAATTACAAGAAGAGATCCCAGTGCTT
CATGAGGAACAAGAGTTACTGCCTAATGTGAAAGAAGTCAGTGAGACTCAGGAAACAATG
AATGAACTGGAGTTATTAACAGAACAGTCCACAACCAAGGACTCAACAACACTGGCAAGA
ATAGAAATGGAAAGGCTCAGGTTGAATGAAAAATTTCAAGAAAGTCAGGAAGAGATAAAA
TCTCTAACCAAGGAAAGAGACAACCTTAAAACGATAAAAGAAGCCCTTGAAGTTAAACAT
GACCAGCTGAAAGAACATATTAGAGAAACTTTGGCTAAAATCCAGGAGTCTCAAAGCAAA
CAAGAACAGTCCTTAAATATGAAAGAAAAAGACAATGAAACTACCAAAATCGTGAGTGAG
ATGGAGCAATTCAAACCCAAAGATTCAGCACTACTAAGGATAGAAATAGAAATGCTCGGA
TTGTCCAAAAGACTTCAAGAAAGTCATGATGAAATGAAATCTGTAGCTAAGGAGAAAGAT
GACCTACAGAGGCTGCAAGAAGTTCTTCAATCTGAAAGTGACCAGCTCAAAGAAAACATA
AAAGAAATTGTAGCTAAACACCTGGAAACTGAAGAGGAACTTAAAGTTGCTCATTGTTGC
CTGAAAGAACAAGAGGAAACTATTAATGAGTTAAGAGTGAATCTTTCAGAGAAGGAAACT
GAAATATCAACCATTCAAAAGCAGTTAGAAGCAATCAATGATAAATTACAGAACAAGATC
CAAGAGATTTATGAGAAAGAGGAACAATTTAATATAAAACAAATTAGTGAGGTTCAGGAA
AAAGTGAATGAACTGAAACAATTCAAGGAGCATCGCAAAGCCAAGGATTCAGCACTACAA
AGTATAGAAAGTAAGATGCTCGAGTTGACCAACAGACTTCAAGAAAGTCAAGAAGAAATA
CAAATTATGATTAAGGAAAAAGAGGAAATGAAAAGAGTACAGGAGGCCCTTCAGATAGAG
AGAGACCAACTGAAAGAAAACACTAAAGAAATTGTAGCTAAAATGAAAGAATCTCAAGAA
AAAGAATATCAGTTTCTTAAGATGACAGCTGTCAATGAGACTCAGGAGAAAATGTGTGAA
ATAGAACACTTGAAGGAGCAATTTGAGACCCAGAAGTTAAACCTGGAAAACATAGAAACG
GAGAATATAAGGTTGACTCAGATACTACATGAAAACCTTGAAGAAATGAGATCTGTAACA
AAAGAAAGAGATGACCTTAGGAGTGTGGAGGAGACTCTCAAAGTAGAGAGAGACCAGCTC
AAGGAAAACCTTAGAGAAACTATAACTAGAGACCTAGAAAAACAAGAGGAGCTAAAAATT
GTTCACATGCATCTGAAGGAGCACCAAGAAACTATTGATAAACTAAGAGGGATTGTTTCA
GAGAAAACAAATGAAATATCAAATATGCAAAAGGACTTAGAACACTCAAATGATGCCTTA
AAAGCACAGGATCTGAAAATACAAGAGGAACTAAGAATTGCTCACATGCATCTGAAAGAG
CAGCAGGAAACTATTGACAAACTCAGAGGAATTGTTTCTGAGAAGACAGATAAACTATCA
AATATGCAAAAAGATTTAGAAAATTCAAATGCTAAATTACAAGAAAAGATTCAAGAACTT
AAGGCAAATGAACATCAACTTATTACGTTAAAAAAAGATGTCAATGAGACACAGAAAAAA
GTGTCTGAAATGGAGCAACTAAAGAAACAAATAAAAGACCAAAGCTTAACTCTGAGTAAA
TTAGAAATAGAGAATTTAAATTTGGCTCAGAAACTTCATGAAAACCTTGAAGAAATGAAA
TCTGTAATGAAAGAAAGAGATAATCTAAGAAGAGTAGAGGAGACACTCAAACTGGAGAGA
GACCAACTCAAGGAAAGCCTGCAAGAAACCAAAGCTAGAGATCTGGAAATACAACAGGAA
CTAAAAACTGCTCGTATGCTATCAAAAGAACACAAAGAAACTGTTGATAAACTTAGAGAA
AAAATTTCAGAAAAGACAATTCAAATTTCAGACATTCAAAAGGATTTAGATAAATCAAAA
GATGAATTACAGAAAAAGCAGGACCGACAGAACCACCAAGTAAAACCTGAAAAAAGGTTA
CTAAGTGATGGACAACAGCACCTTACGGAAAGCCTGAGAGAAAAGTGCTCTAGAATAAAA
GAGCTTTTGAAGAGATACTCAGAGATGGATGATCATTATGAGTGCTTGAATAGATTGTCT
CTTGACTTGGAGAAGGAAATTGAATTCCAAAAAGAGCTTTCAATGAGAGTTAAAGCAAAC
CTCTCACTTCCCTATTTACAAACCAAACACATTGAAAAACTTTTTACTGCAAACCAGAGA
TGCTCCATGGAATTCCACAGAATCATGAAGAAACTGAAGTATGTGTTAAGCTATGTTACA
AAAATAAAAGAAGAACAACATGAATCCATCAATAAATTTGAAATGGATTTTATTGATGAA
GTGGAAAAGCAAAAGGAATTGCTAATTAAAATACAGCACCTTCAACAAGATTGTGATGTA
CCATCCAGAGAATTAAGGGATCTCAAATTGAACCAGAATATGGATCTACATATTGAGGAA
ATTCTCAAAGATTTCTCAGAAAGTGAGTTCCCTAGCATAAAGACTGAATTTCAACAAGTA
CTAAGTAATAGGAAAGAAATGACACAGTTTTTGGAAGAGTGGTTAAATACTCGTTTTGAT
ATAGAAAAGCTTAAAAATGGCATCCAGAAAGAAAATGATAGGATTTGTCAAGTGAATAAC
TTCTTTAATAACAGAATAATTGCCATAATGAATGAATCAACAGAGTTTGAGGAAAGAAGT
GCTACCATATCCAAAGAGTGGGAACAGGACCTGAAATCACTGAAAGAGAAAAATGAAAAA
CTATTTAAAAACTACCAAACATTGAAGACTTCCTTGGCATCTGGTGCCCAGGTTAATCCT
ACCACACAAGACAATAAGAATCCTCATGTTACATCAAGAGCTACACAGTTAACCACAGAG
AAAATTCGAGAGCTGGAAAATTCACTGCATGAAGCTAAAGAAAGTGCTATGCATAAGGAA
AGCAAGATTATAAAGATGCAGAAAGAACTTGAGGTGACTAATGACATAATAGCAAAACTT
CAAGCCAAAGTTCATGAATCAAATAAATGCCTTGAAAAAACAAAAGAGACAATTCAAGTA
CTTCAGGACAAAGTTGCTTTAGGAGCTAAGCCATATAAAGAAGAAATTGAAGATCTCAAA
ATGAAGCTTGTGAAAATAGACCTAGAGAAAATGAAAAATGCCAAAGAATTTGAAAAGGAA
ATCAGTGCTACAAAAGCCACTGTAGAATATCAAAAGGAAGTTATAAGGCTATTGAGAGAA
AATCTCAGAAGAAGTCAACAGGCCCAAGATACCTCAGTGATATCAGAACATACTGATCCT
CAGCCTTCAAATAAACCCTTAACTTGTGGAGGTGGCAGCGGCATTGTACAAAACACAAAA
GCTCTTATTTTGAAAAGTGAACATATAAGGCTAGAAAAAGAAATTTCTAAGTTAAAGCAG
CAAAATGAACAGCTAATAAAACAAAAGAATGAATTGTTAAGCAATAATCAGCATCTTTCC
AATGAGGTCAAAACTTGGAAGGAAAGAACCCTTAAAAGAGAGGCTCACAAACAAGTAACT
TGTGAGAATTCTCCAAAGTCTCCTAAAGTGACTGGAACAGCTTCTAAAAAGAAACAAATT
ACACCCTCTCAATGCAAGGAACGGAATTTACAAGATCCTGTGCCAAAGGAATCACCAAAA
TCTTGTTTTTTTGATAGCCGATCAAAGTCTTTACCATCACCTCATCCAGTTCGCTATTTT
GATAACTCAAGTTTAGGCCTTTGTCCAGAGGTGCAAAATGCAGGAGCAGAGAGTGTGGAT
TCTCAGCCAGGTCCTTGGCACGCCTCCTCAGGCAAGGATGTGCCTGAGTGCAAAACTCAG
TAG
Chromosome Location
4
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ02224
UniProtKB Entry NameCENPE_HUMAN
GenBank Gene IDCH471057
GenAtlas IDCENPE
HGNC IDHGNC:1856
General References
  1. Yen TJ, Li G, Schaar BT, Szilak I, Cleveland DW: CENP-E is a putative kinetochore motor that accumulates just before mitosis. Nature. 1992 Oct 8;359(6395):536-9. [Article]
  2. Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature. 2005 Apr 7;434(7034):724-31. [Article]
  3. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  4. Thrower DA, Jordan MA, Schaar BT, Yen TJ, Wilson L: Mitotic HeLa cells contain a CENP-E-associated minus end-directed microtubule motor. EMBO J. 1995 Mar 1;14(5):918-26. [Article]
  5. Chan GK, Schaar BT, Yen TJ: Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1. J Cell Biol. 1998 Oct 5;143(1):49-63. [Article]
  6. Ashar HR, James L, Gray K, Carr D, Black S, Armstrong L, Bishop WR, Kirschmeier P: Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules. J Biol Chem. 2000 Sep 29;275(39):30451-7. [Article]
  7. Kurasawa Y, Earnshaw WC, Mochizuki Y, Dohmae N, Todokoro K: Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation. EMBO J. 2004 Aug 18;23(16):3237-48. Epub 2004 Aug 5. [Article]
  8. Liu D, Ding X, Du J, Cai X, Huang Y, Ward T, Shaw A, Yang Y, Hu R, Jin C, Yao X: Human NUF2 interacts with centromere-associated protein E and is essential for a stable spindle microtubule-kinetochore attachment. J Biol Chem. 2007 Jul 20;282(29):21415-24. Epub 2007 May 29. [Article]
  9. Denis NJ, Vasilescu J, Lambert JP, Smith JC, Figeys D: Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. Proteomics. 2007 Mar;7(6):868-74. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB06097GSK-923295investigationalunknownDetails