Protein-glutamine gamma-glutamyltransferase E
Details
- Name
- Protein-glutamine gamma-glutamyltransferase E
- Synonyms
- 2.3.2.13
- TG(E)
- TGase E
- TGase-3
- TGE
- Transglutaminase E
- Transglutaminase-3
- Gene Name
- TGM3
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0010887|Protein-glutamine gamma-glutamyltransferase E MAALGVQSINWQTAFNRQAHHTDKFSSQELILRRGQNFQVLMIMNKGLGSNERLEFIVST GPYPSESAMTKAVFPLSNGSSGGWSAVLQASNGNTLTISISSPASAPIGRYTMALQIFSQ GGISSVKLGTFILLFNPWLNVDSVFMGNHAEREEYVQEDAGIIFVGSTNRIGMIGWNFGQ FEEDILSICLSILDRSLNFRRDAATDVASRNDPKYVGRVLSAMINSNDDNGVLAGNWSGT YTGGRDPRSWNGSVEILKNWKKSGFSPVRYGQCWVFAGTLNTALRSLGIPSRVITNFNSA HDTDRNLSVDVYYDPMGNPLDKGSDSVWNFHVWNEGWFVRSDLGPSYGGWQVLDATPQER SQGVFQCGPASVIGVREGDVQLNFDMPFIFAEVNADRITWLYDNTTGKQWKNSVNSHTIG RYISTKAVGSNARMDVTDKYKYPEGSDQERQVFQKALGKLKPNTPFAATSSMGLETEEQE PSIIGKLKVAGMLAVGKEVNLVLLLKNLSRDTKTVTVNMTAWTIIYNGTLVHEVWKDSAT MSLDPEEEAEHPIKISYAQYEKYLKSDNMIRITAVCKVPDESEVVVERDIILDNPTLTLE VLNEARVRKPVNVQMLFSNPLDEPVRDCVLMVEGSGLLLGNLKIDVPTLGPKEGSRVRFD ILPSRSGTKQLLADFSCNKFPAIKAMLSIDVAE
- Number of residues
- 693
- Molecular Weight
- 76631.26
- Theoretical pI
- 5.6
- GO Classification
- Functionscalcium ion binding / catalytic activity / protein-glutamine gamma-glutamyltransferase activity / transferase activity, transferring acyl groupsProcessescell envelope organization / cellular protein modification process / hair follicle morphogenesis / keratinization / keratinocyte differentiation / peptide cross-linking / protein tetramerizationComponentscytoplasm / extracellular exosome / extrinsic component of cytoplasmic side of plasma membrane
- General Function
- Transferase activity, transferring acyl groups
- Specific Function
- Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0010888|Protein-glutamine gamma-glutamyltransferase E (TGM3) ATGGCTGCTCTAGGAGTCCAGAGTATCAACTGGCAGACGGCCTTCAACCGACAAGCGCAT CACACAGACAAGTTCTCCAGCCAGGAGCTCATCTTGCGGAGAGGCCAAAACTTCCAGGTC TTAATGATCATGAACAAAGGCCTTGGCTCTAACGAAAGACTGGAGTTCATTGTCTCCACA GGGCCTTACCCCTCAGAGTCGGCCATGACGAAGGCTGTGTTTCCACTCTCCAATGGCAGT AGTGGTGGCTGGAGTGCGGTGCTTCAGGCCAGCAATGGCAATACTCTGACTATCAGCATC TCCAGTCCTGCCAGCGCACCCATAGGACGGTACACAATGGCCCTCCAGATCTTCTCCCAG GGCGGCATCTCCTCTGTGAAACTTGGGACGTTCATACTGCTTTTTAACCCCTGGCTGAAT GTGGATAGCGTCTTTATGGGTAACCACGCTGAGAGAGAAGAGTATGTTCAGGAAGATGCC GGCATCATCTTTGTGGGAAGCACAAACCGAATTGGCATGATTGGCTGGAACTTTGGACAG TTTGAAGAAGACATTCTCAGCATCTGCCTCTCAATCTTGGATAGGAGTCTGAATTTCCGC CGTGACGCTGCTACTGATGTGGCCAGCAGAAATGACCCCAAATACGTTGGCCGGGTGCTG AGTGCCATGATCAATAGCAATGATGACAATGGTGTGCTTGCTGGGAATTGGAGCGGCACT TACACCGGTGGCCGGGACCCAAGGAGCTGGAACGGCAGCGTGGAGATCCTCAAAAATTGG AAAAAATCTGGCTTCAGCCCAGTCCGATATGGCCAGTGCTGGGTCTTTGCTGGGACCCTC AACACAGCGCTGCGGTCTTTGGGGATTCCTTCCCGGGTGATCACCAACTTCAACTCAGCT CATGACACAGACCGAAATCTCAGTGTGGATGTGTACTACGACCCCATGGGAAACCCCCTG GACAAGGGTAGTGATAGCGTATGGAATTTCCATGTCTGGAATGAAGGCTGGTTTGTGAGG TCTGACCTGGGCCCCTCGTACGGTGGATGGCAGGTGTTGGATGCTACCCCGCAGGAAAGA AGCCAAGGGGTGTTCCAGTGCGGCCCCGCTTCGGTCATTGGTGTTCGAGAGGGTGATGTG CAGCTGAACTTCGACATGCCCTTTATCTTCGCGGAGGTTAATGCCGACCGCATCACCTGG CTGTACGACAACACCACTGGCAAACAGTGGAAGAATTCCGTGAACAGTCACACCATTGGC AGGTACATCAGCACCAAGGCGGTGGGCAGCAATGCTCGCATGGACGTCACGGACAAGTAC AAGTACCCAGAAGGCTCTGACCAGGAAAGACAAGTGTTCCAAAAGGCTTTGGGGAAACTT AAACCCAACACGCCATTTGCCGCGACGTCTTCAATGGGTTTGGAAACAGAGGAACAGGAG CCCAGCATCATCGGGAAGCTGAAGGTCGCTGGCATGCTGGCAGTAGGCAAAGAAGTCAAC CTGGTCCTACTGCTCAAAAACCTGAGCAGGGATACGAAGACAGTGACAGTGAACATGACA GCCTGGACCATCATCTACAACGGCACGCTTGTACATGAAGTGTGGAAGGACTCTGCCACA ATGTCCCTGGACCCTGAGGAAGAGGCAGAACATCCCATAAAGATCTCGTACGCTCAGTAT GAGAAGTACCTGAAGTCAGACAACATGATCCGGATCACAGCGGTGTGCAAGGTCCCAGAT GAGTCTGAGGTGGTGGTGGAGCGGGACATCATCCTGGACAACCCCACCTTGACCCTGGAG GTGCTGAACGAGGCTCGTGTGCGGAAGCCTGTGAACGTGCAGATGCTCTTCTCCAATCCA CTGGATGAGCCGGTGAGGGACTGCGTGCTGATGGTGGAGGGAAGCGGCCTGCTGTTGGGT AACCTGAAGATCGACGTGCCGACCCTAGGGCCCAAGGAGGGGTCCCGGGTCCGTTTTGAT ATCCTGCCCTCCCGGAGTGGCACCAAGCAACTGCTCGCCGACTTCTCCTGCAACAAGTTC CCTGCAATCAAGGCCATGTTGTCCATCGATGTAGCCGAATGA
- Chromosome Location
- 20
- Locus
- 20q11.2
- External Identifiers
Resource Link UniProtKB ID Q08188 UniProtKB Entry Name TGM3_HUMAN GenBank Protein ID 307504 GenBank Gene ID L10386 GenAtlas ID TGM3 HGNC ID HGNC:11779 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB01864 5'-Guanosine-Diphosphate-Monothiophosphate experimental unknown Details DB01972 Guanosine-5'-Monophosphate experimental unknown Details DB03152 B-2-Octylglucoside experimental unknown Details DB04315 Guanosine-5'-Diphosphate experimental unknown Details DB00130 L-Glutamine approved, investigational, nutraceutical unknown substrate Details