Glucose-dependent insulinotropic receptor
Details
- Name
- Glucose-dependent insulinotropic receptor
- Synonyms
- G-protein coupled receptor 119
- Gene Name
- GPR119
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0012362|Glucose-dependent insulinotropic receptor MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISG LLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGF VAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLL FVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTP FLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKV LTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
- Number of residues
- 335
- Molecular Weight
- 36888.36
- Theoretical pI
- 8.96
- GO Classification
- FunctionsG-protein coupled receptor activity / phosphatidylcholine bindingProcessesinsulin secretionComponentsintegral component of membrane / plasma membrane / receptor complex
- General Function
- Phosphatidylcholine binding
- Specific Function
- Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.
- Pfam Domain Function
- 7tm_1 (PF00001)
- Transmembrane Regions
- 13-33 38-58 82-102 126-146 165-185 227-247 263-283
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0012363|Glucose-dependent insulinotropic receptor (GPR119) ATGGAATCATCTTTCTCATTTGGAGTGATCCTTGCTGTCCTGGCCTCCCTCATCATTGCT ACTAACACACTAGTGGCTGTGGCTGTGCTGCTGTTGATCCACAAGAATGATGGTGTCAGT CTCTGCTTCACCTTGAATCTGGCTGTGGCTGACACCTTGATTGGTGTGGCCATCTCTGGC CTACTCACAGACCAGCTCTCCAGCCCTTCTCGGCCCACACAGAAGACCCTGTGCAGCCTG CGGATGGCATTTGTCACTTCCTCCGCAGCTGCCTCTGTCCTCACGGTCATGCTGATCACC TTTGACAGGTACCTTGCCATCAAGCAGCCCTTCCGCTACTTGAAGATCATGAGTGGGTTC GTGGCCGGGGCCTGCATTGCCGGGCTGTGGTTAGTGTCTTACCTCATTGGCTTCCTCCCA CTCGGAATCCCCATGTTCCAGCAGACTGCCTACAAAGGGCAGTGCAGCTTCTTTGCTGTA TTTCACCCTCACTTCGTGCTGACCCTCTCCTGCGTTGGCTTCTTCCCAGCCATGCTCCTC TTTGTCTTCTTCTACTGCGACATGCTCAAGATTGCCTCCATGCACAGCCAGCAGATTCGA AAGATGGAACATGCAGGAGCCATGGCTGGAGGTTATCGATCCCCACGGACTCCCAGCGAC TTCAAAGCTCTCCGTACTGTGTCTGTTCTCATTGGGAGCTTTGCTCTATCCTGGACCCCC TTCCTTATCACTGGCATTGTGCAGGTGGCCTGCCAGGAGTGTCACCTCTACCTAGTGCTG GAACGGTACCTGTGGCTGCTCGGCGTGGGCAACTCCCTGCTCAACCCACTCATCTATGCC TATTGGCAGAAGGAGGTGCGACTGCAGCTCTACCACATGGCCCTAGGAGTGAAGAAGGTG CTCACCTCATTCCTCCTCTTTCTCTCGGCCAGGAATTGTGGCCCAGAGAGGCCCAGGGAA AGTTCCTGTCACATCGTCACTATCTCCAGCTCAGAGTTTGATGGCTAA
- Chromosome Location
- X
- Locus
- Xq25
- External Identifiers
Resource Link UniProtKB ID Q8TDV5 UniProtKB Entry Name GP119_HUMAN GenBank Gene ID AB083584 GenAtlas ID GPR119 HGNC ID HGNC:19060 - General References
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