Leukotriene B4 receptor 2
Details
- Name
- Leukotriene B4 receptor 2
- Synonyms
- BLT2R
- BLTR2
- Leukotriene B4 receptor BLT2
- LTB4 receptor JULF2
- LTB4-R 2
- Seven transmembrane receptor BLTR2
- Gene Name
- LTB4R2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0006761|Leukotriene B4 receptor 2 MAPSHRASQVGFCPTPERPLWRLPPTCRPRRMSVCYRPPGNETLLSWKTSRATGTAFLLL AALLGLPGNGFVVWSLAGWRPARGRPLAATLVLHLALADGAVLLLTPLFVAFLTRQAWPL GQAGCKAVYYVCALSMYASVLLTGLLSLQRCLAVTRPFLAPRLRSPALARRLLLAVWLAA LLLAVPAAVYRHLWRDRVCQLCHPSPVHAAAHLSLETLTAFVLPFGLMLGCYSVTLARLR GARWGSGRHGARVGRLVSAIVLAFGLLWAPYHAVNLLQAVAALAPPEGALAKLGGAGQAA RAGTTALAFFSSSVNPVLYVFTAGDLLPRAGPRFLTRLFEGSGEARGGGRSREGTMELRT TPQLKVVGQGRGNGDPGGGMEKDGPEWDL
- Number of residues
- 389
- Molecular Weight
- 41524.35
- Theoretical pI
- 11.49
- GO Classification
- FunctionsG-protein coupled peptide receptor activity / leukotriene B4 receptor activity / leukotriene receptor activityProcesseschemotaxis / inflammatory response / keratinocyte migration / leukotriene signaling pathway / negative regulation of adenylate cyclase activity / neuropeptide signaling pathway / phospholipase C-activating G-protein coupled receptor signaling pathwayComponentsintegral component of plasma membrane / membrane / plasma membrane
- General Function
- Leukotriene receptor activity
- Specific Function
- Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3.
- Pfam Domain Function
- 7tm_1 (PF00001)
- Transmembrane Regions
- 56-76 92-112 128-148 173-193 217-237 257-277 307-327
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0012432|Leukotriene B4 receptor 2 (LTB4R2) ATGTCGGTCTGCTACCGTCCCCCAGGGAACGAGACACTGCTGAGCTGGAAGACTTCGCGG GCCACAGGCACAGCCTTCCTGCTGCTGGCGGCGCTGCTGGGGCTGCCTGGCAACGGCTTC GTGGTGTGGAGCTTGGCGGGCTGGCGGCCTGCACGGGGGCGACCGCTGGCGGCCACGCTT GTGCTGCACCTGGCGCTGGCCGACGGCGCGGTGCTGCTGCTCACGCCGCTCTTTGTGGCC TTCCTGACCCGGCAGGCCTGGCCGCTGGGCCAGGCGGGCTGCAAGGCGGTGTACTACGTG TGCGCGCTCAGCATGTACGCCAGCGTGCTGCTCACCGGCCTGCTCAGCCTGCAGCGCTGC CTCGCAGTCACCCGCCCCTTCCTGGCGCCTCGGCTGCGCAGCCCGGCCCTGGCCCGCCGC CTGCTGCTGGCGGTCTGGCTGGCCGCCCTGTTGCTCGCCGTCCCGGCCGCCGTCTACCGC CACCTGTGGAGGGACCGCGTATGCCAGCTGTGCCACCCGTCGCCGGTCCACGCCGCCGCC CACCTGAGCCTGGAGACTCTGACCGCTTTCGTGCTTCCTTTCGGGCTGATGCTCGGCTGC TACAGCGTGACGCTGGCACGGCTGCGGGGCGCCCGCTGGGGCTCCGGGCGGCACGGGGCG CGGGTGGGCCGGCTGGTGAGCGCCATCGTGCTTGCCTTCGGCTTGCTCTGGGCCCCCTAC CACGCAGTCAACCTTCTGCAGGCGGTCGCAGCGCTGGCTCCACCGGAAGGGGCCTTGGCG AAGCTGGGCGGAGCCGGCCAGGCGGCGCGAGCGGGAACTACGGCCTTGGCCTTCTTCAGT TCTAGCGTCAACCCGGTGCTCTACGTCTTCACCGCTGGAGATCTGCTGCCCCGGGCAGGT CCCCGTTTCCTCACGCGGCTCTTCGAAGGCTCTGGGGAGGCCCGAGGGGGCGGCCGCTCT AGGGAAGGGACCATGGAGCTCCGAACTACCCCTCAGCTGAAAGTGGTGGGGCAGGGCCGC GGCAATGGAGACCCGGGGGGTGGGATGGAGAAGGACGGTCCGGAATGGGACCTTTGA
- Chromosome Location
- 14
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9NPC1 UniProtKB Entry Name LT4R2_HUMAN GenBank Gene ID AB083604 GenAtlas ID LTB4R2 HGNC ID HGNC:19260 - General References
- Tryselius Y, Nilsson NE, Kotarsky K, Olde B, Owman C: Cloning and characterization of cDNA encoding a novel human leukotriene B(4) receptor. Biochem Biophys Res Commun. 2000 Aug 2;274(2):377-82. [Article]
- Yokomizo T, Kato K, Terawaki K, Izumi T, Shimizu T: A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders. J Exp Med. 2000 Aug 7;192(3):421-32. [Article]
- Heilig R, Eckenberg R, Petit JL, Fonknechten N, Da Silva C, Cattolico L, Levy M, Barbe V, de Berardinis V, Ureta-Vidal A, Pelletier E, Vico V, Anthouard V, Rowen L, Madan A, Qin S, Sun H, Du H, Pepin K, Artiguenave F, Robert C, Cruaud C, Bruls T, Jaillon O, Friedlander L, Samson G, Brottier P, Cure S, Segurens B, Aniere F, Samain S, Crespeau H, Abbasi N, Aiach N, Boscus D, Dickhoff R, Dors M, Dubois I, Friedman C, Gouyvenoux M, James R, Madan A, Mairey-Estrada B, Mangenot S, Martins N, Menard M, Oztas S, Ratcliffe A, Shaffer T, Trask B, Vacherie B, Bellemere C, Belser C, Besnard-Gonnet M, Bartol-Mavel D, Boutard M, Briez-Silla S, Combette S, Dufosse-Laurent V, Ferron C, Lechaplais C, Louesse C, Muselet D, Magdelenat G, Pateau E, Petit E, Sirvain-Trukniewicz P, Trybou A, Vega-Czarny N, Bataille E, Bluet E, Bordelais I, Dubois M, Dumont C, Guerin T, Haffray S, Hammadi R, Muanga J, Pellouin V, Robert D, Wunderle E, Gauguet G, Roy A, Sainte-Marthe L, Verdier J, Verdier-Discala C, Hillier L, Fulton L, McPherson J, Matsuda F, Wilson R, Scarpelli C, Gyapay G, Wincker P, Saurin W, Quetier F, Waterston R, Hood L, Weissenbach J: The DNA sequence and analysis of human chromosome 14. Nature. 2003 Feb 6;421(6923):601-7. Epub 2003 Jan 1. [Article]
- Wang S, Gustafson E, Pang L, Qiao X, Behan J, Maguire M, Bayne M, Laz T: A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization. J Biol Chem. 2000 Dec 29;275(52):40686-94. [Article]
- Kamohara M, Takasaki J, Matsumoto M, Saito T, Ohishi T, Ishii H, Furuichi K: Molecular cloning and characterization of another leukotriene B4 receptor. J Biol Chem. 2000 Sep 1;275(35):27000-4. [Article]
- Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S: Identification of G protein-coupled receptor genes from the human genome sequence. FEBS Lett. 2002 Jun 5;520(1-3):97-101. [Article]