Reaction: Tretinoin to 1 product
- Reaction
- Reaction type
- isomerization
- Direction
- Major circulating metabolite?
- No
- Spontaneous?
- No
- Activity
- unknown
- References
- Marill J, Capron CC, Idres N, Chabot GG: Human cytochrome P450s involved in the metabolism of 9-cis- and 13-cis-retinoic acids. Biochem Pharmacol. 2002 Mar 1;63(5):933-43. doi: 10.1016/s0006-2952(01)00925-x. [Article]
- Marill J, Idres N, Capron CC, Nguyen E, Chabot GG: Retinoic acid metabolism and mechanism of action: a review. Curr Drug Metab. 2003 Feb;4(1):1-10. doi: 10.2174/1389200033336900. [Article]
- Regazzi MB, Iacona I, Gervasutti C, Lazzarino M, Toma S: Clinical pharmacokinetics of tretinoin. Clin Pharmacokinet. 1997 May;32(5):382-402. doi: 10.2165/00003088-199732050-00004. [Article]
- Gillis JC, Goa KL: Tretinoin. A review of its pharmacodynamic and pharmacokinetic properties and use in the management of acute promyelocytic leukaemia. Drugs. 1995 Nov;50(5):897-923. doi: 10.2165/00003495-199550050-00008. [Article]
- FDA Approved Drug Products: VESANOID (tretinoin) capsules, for oral use [Link]
- Comments
- This reaction may be spontaneous or performed by isomerases.
- Enzymes
Enzyme Km Vmax Role Cytochrome P450 2C9 Not Available Not Available implied Cytochrome P450 2C8 Not Available Not Available implied Cytochrome P450 3A4 Not Available Not Available implied