Reaction: Escitalopram to 1 product

Reaction
Escitalopram
DB01175
Escitalopram N-oxide
DBMET03672
Reaction type
N-oxidation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Olesen OV, Linnet K: Studies on the stereoselective metabolism of citalopram by human liver microsomes and cDNA-expressed cytochrome P450 enzymes. Pharmacology. 1999 Dec;59(6):298-309. doi: 10.1159/000028333. [Article]
  2. Berzas-Nevado JJ, Villasenor-Llerena MJ, Guiberteau-Cabanillas C, Rodriguez-Robledo V: Enantiomeric screening of racemic citalopram and metabolites in human urine by entangled polymer solution capillary electrophoresis: an innovatory robustness/ruggedness study. Electrophoresis. 2006 Feb;27(4):905-17. doi: 10.1002/elps.200500413. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 2D6Not AvailableNot Availableconfirmed