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Identification
NameEscitalopram
Accession NumberDB01175  (APRD00683)
TypeSmall Molecule
GroupsApproved, Investigational
Description

Escitalopram, the S-enantiomer of citalopram, belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). Despite distinct structural differences between compounds in this class, SSRIs possess similar pharmacological activity. As with other antidepressant agents, several weeks of therapy may be required before a clinical effect is seen. SSRIs are potent inhibitors of neuronal serotonin reuptake. They have little to no effect on norepinephrine or dopamine reuptake and do not antagonize α- or β-adrenergic, dopamine D2 or histamine H1 receptors. During acute use, SSRIs block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Chronic use leads to desensitization of somatodendritic 5-HT1A and terminal autoreceptors. The overall clinical effect of increased mood and decreased anxiety is thought to be due to adaptive changes in neuronal function that leads to enhanced serotonergic neurotransmission. Side effects include dry mouth, nausea, dizziness, drowsiness, sexual dysfunction and headache. Side effects generally occur within the first two weeks of therapy and are usually less severe and frequent than those observed with tricyclic antidepressants. Escitalopram may be used to treat major depressive disorder (MDD) and generalized anxiety disorder (GAD).

Structure
Thumb
Synonyms
(+)-Citalopram
(S)-Citalopram
Escitalopram Oxalate
Escitalopramum
Esertia
S-(+)-Citalopram
S(+)-Citalopram
External Identifiers Not Available
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Ach-escitalopramtablet20 mgoralAccord Healthcare IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ach-escitalopramtablet10 mgoralAccord Healthcare IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Act Escitalopramtablet20 mgoralActavis Pharma Company2014-09-10Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Act Escitalopramtablet5 mgoralActavis Pharma CompanyNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Act Escitalopramtablet10 mgoralActavis Pharma Company2014-09-10Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Auro-escitalopramtablet20 mgoralAuro Pharma Inc2014-09-10Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Auro-escitalopramtablet5 mgoralAuro Pharma IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Auro-escitalopramtablet10 mgoralAuro Pharma Inc2014-09-10Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Auro-escitalopramtablet15 mgoralAuro Pharma IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Cipralex -5mgtablet5 mgoralLundbeck Canada IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Cipralex -10mgtablet10 mgoralLundbeck Canada Inc2005-02-14Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Cipralex -15mgtablet15 mgoralLundbeck Canada IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Cipralex -20mgtablet20 mgoralLundbeck Canada Inc2005-02-14Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Cipralex Meltztablet (orally disintegrating)10 mgoralLundbeck Canada Inc2012-10-04Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Cipralex Meltztablet (orally disintegrating)20 mgoralLundbeck Canada Inc2012-10-04Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Escitalopramtablet20 mgoralPro Doc Limitee2014-09-15Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Escitalopramtablet10 mgoralPro Doc Limitee2014-09-15Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Escitalopramtablet20 mgoralSivem Pharmaceuticals Ulc2015-01-14Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Escitalopramtablet20 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Escitalopramtablet10 mgoralSivem Pharmaceuticals Ulc2015-01-14Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Escitalopramtablet10 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Escitalopramtablet20 mgoralSanis Health Inc2014-09-18Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Escitalopramtablet10 mgoralSanis Health Inc2014-09-18Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Escitalopram Oxalatetablet, film coated5 mg/1oralMylan Pharmaceuticals Inc.2012-02-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopram Oxalatetablet, film coated20 mg/1oralMylan Institutional Inc.2012-02-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopram Oxalatesolution5 mg/5mLoralActavis Pharma, Inc.2015-04-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopram Oxalatetablet, film coated10 mg/1oralREMEDYREPACK INC.2015-12-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopram Oxalatetablet, film coated20 mg/1oralPhysicians Total Care, Inc.2012-10-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopram Oxalatetablet, film coated10 mg/1oralPhysicians Total Care, Inc.2012-10-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopram Oxalatetablet, film coated20 mg/1oralCardinal Health2002-08-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopram Oxalatetablet, film coated10 mg/1oralCardinal Health2002-08-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopram Oxalatetablet, film coated20 mg/1oralMylan Pharmaceuticals Inc.2012-02-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopram Oxalatetablet, film coated10 mg/1oralMylan Institutional Inc.2012-02-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopram Oxalatetablet, film coated10 mg/1oralMylan Pharmaceuticals Inc.2012-02-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Ipg-escitalopramtablet20 mgoralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ipg-escitalopramtablet15 mgoralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ipg-escitalopramtablet10 mgoralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ipg-escitalopramtablet5 mgoralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Jamp-escitalopramtablet20 mgoralJamp Pharma Corporation2014-09-11Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Jamp-escitalopramtablet10 mgoralJamp Pharma Corporation2014-09-11Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Lexaprotablet, film coated20 mg/1oralCardinal Health2002-08-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lexaprotablet, film coated20 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-12-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lexaprosolution5 mg/5mLoralForest Laboratories, Inc.2002-11-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lexaprotablet, film coated10 mg/1oralCardinal Health2002-08-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lexaprotablet, film coated10 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-12-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lexaprotablet, film coated20 mg/1oralPd Rx Pharmaceuticals, Inc.2002-08-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lexaprotablet, film coated20 mg/1oralForest Laboratories, Inc.2002-08-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lexaprotablet, film coated10 mg/1oralAidarex Pharmaceuticals LLC2002-08-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lexaprotablet, film coated10 mg/1oralPd Rx Pharmaceuticals, Inc.2002-08-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lexaprotablet, film coated10 mg/1oralForest Laboratories, Inc.2002-08-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lexaprotablet, film coated20 mg/1oralAidarex Pharmaceuticals LLC2002-08-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lexaprotablet, film coated5 mg/1oralForest Laboratories, Inc.2002-08-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lexaprotablet5 mg/1oralPhysicians Total Care, Inc.2009-11-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lexaprotablet, film coated20 mg/1oralREMEDYREPACK INC.2013-03-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lexaprotablet20 mg/1oralPhysicians Total Care, Inc.2009-04-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lexaprotablet, film coated5 mg/1oralSTAT Rx USA LLC2002-08-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lexaprotablet20 mg/1oralCardinal Health2002-08-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lexaprotablet, film coated10 mg/1oralbryant ranch prepack2002-08-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lexaprotablet10 mg/1oralPhysicians Total Care, Inc.2005-12-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lexaprotablet, film coated10 mg/1oralSTAT Rx USA LLC2002-08-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lexaprotablet10 mg/1oralCardinal Health2002-08-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lexaprotablet, film coated10 mg/1oralUnit Dose Services2002-08-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lexaprotablet, film coated20 mg/1oralbryant ranch prepack2002-08-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Mar-escitalopramtablet5 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mar-escitalopramtablet20 mgoralMarcan Pharmaceuticals Inc2014-09-10Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mar-escitalopramtablet10 mgoralMarcan Pharmaceuticals Inc2014-09-10Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mar-escitalopramtablet15 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mint-escitalopramtablet20 mgoralMint Pharmaceuticals Inc2015-03-19Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mint-escitalopramtablet15 mgoralMint Pharmaceuticals IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mint-escitalopramtablet10 mgoralMint Pharmaceuticals Inc2015-03-19Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mylan-escitalopramtablet20 mgoralMylan Pharmaceuticals Ulc2014-09-10Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mylan-escitalopramtablet10 mgoralMylan Pharmaceuticals Ulc2014-09-10Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nat-escitalopramtablet10 mgoralNatco Pharma (Canada) Inc2015-07-22Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nat-escitalopramtablet20 mgoralNatco Pharma (Canada) Inc2015-07-22Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-escitalopramtablet15 mgoralPharmascience IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-escitalopramtablet5 mgoralPharmascience IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-escitalopramtablet20 mgoralPharmascience Inc2014-09-10Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-escitalopramtablet10 mgoralPharmascience Inc2014-09-10Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Priva-escitalopramtablet10 mgoralPharmapar Inc2014-09-10Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Priva-escitalopramtablet20 mgoralPharmapar Inc2014-09-10Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ran-escitalopramtablet20 mgoralRanbaxy Pharmaceuticals Canada Inc.2014-09-10Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ran-escitalopramtablet10 mgoralRanbaxy Pharmaceuticals Canada Inc.2014-09-10Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Riva-escitalopramtablet15 mgoralLaboratoire Riva IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Riva-escitalopramtablet20 mgoralLaboratoire Riva Inc2014-09-25Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Riva-escitalopramtablet10 mgoralLaboratoire Riva Inc2014-09-25Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Riva-escitalopramtablet5 mgoralLaboratoire Riva IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sandoz Escitalopramtablet20 mgoralSandoz Canada Incorporated2014-09-10Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sandoz Escitalopramtablet10 mgoralSandoz Canada Incorporated2014-09-10Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Teva-escitalopramtablet15 mgoralTeva Canada LimitedNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Teva-escitalopramtablet5 mgoralTeva Canada LimitedNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Teva-escitalopramtablet20 mgoralTeva Canada Limited2014-09-10Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Teva-escitalopramtablet10 mgoralTeva Canada Limited2014-09-10Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-escitalopramtablet20 mgoralApotex Inc2014-09-10Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Apo-escitalopramtablet10 mgoralApotex Inc2014-09-10Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Escitalopramtablet, film coated20 mg/1oralREMEDYREPACK INC.2013-09-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet10 mg/1oralLupin Pharmaceuticals, Inc.2012-09-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated20 mg/1oralProficient Rx LP2012-03-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated10 mg/1oralHikma Pharmaceutical2012-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated10 mg/1oralRebel Distributors Corp2012-03-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated20 mg/1oralSolco Healthcare US, LLC2012-03-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated5 mg/1oralTeva Pharmaceuticals USA Inc2012-03-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated20 mg/1oralPreferred Pharmaceuticals, Inc.2014-09-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated20 mg/1oralApotex Corp.2012-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated20 mg/1oralREMEDYREPACK INC.2013-02-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated10 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2012-03-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet10 mg/1oralCamber Pharmaceuticals2012-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated10 mg/1oralSTI Pharma LLC2013-09-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated10 mg/1oralREMEDYREPACK INC.2013-05-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated20 mg/1oralCitron Pharma LLC2012-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated5 mg/1oralREMEDYREPACK INC.2016-01-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated20 mg/1oralBlue Point Laboratories2014-02-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated10 mg/1oralApotex Corp.2012-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated10 mg/1oralREMEDYREPACK INC.2013-02-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2012-03-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet5 mg/1oralCamber Pharmaceuticals2012-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated5 mg/1oralSTI Pharma LLC2013-09-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated10 mg/1oralPreferred Pharmaceuticals, Inc.2015-03-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet20 mg/1oralTYA Pharmaceuticals2012-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramsolution5 mg/5mLoralTaro Pharmaceuticals U.S.A., Inc.2012-05-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated10 mg/1oralCitron Pharma LLC2012-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated5 mg/1oralAvera Mc Kennan Hospital2015-03-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated10 mg/1oralBlue Point Laboratories2014-02-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated20 mg/1oralPd Rx Pharmaceuticals, Inc.2012-03-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated5 mg/1oralWest Ward Pharmaceuticals Corp2012-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated20 mg/1oralRebel Distributors Corp2012-03-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet10 mg/1oralLegacy Pharmaceutical Packaging2012-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet10 mg/1oralTYA Pharmaceuticals2012-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated5 mg/1oralApotex Corp.2012-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated20 mg/1oralNorthwind Pharmaceuticals2014-03-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated5 mg/1oralCitron Pharma LLC2012-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated5 mg/1oralBlue Point Laboratories2014-02-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated10 mg/1oralREMEDYREPACK INC.2015-03-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated20 mg/1oralPd Rx Pharmaceuticals, Inc.2012-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated10 mg/1oralWest Ward Pharmaceuticals Corp2012-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated20 mg/1oralAccord Healthcare Inc.2013-01-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated10 mg/1oralInternational Labs, Inc.2013-09-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet20 mg/1oralLegacy Pharmaceutical Packaging2012-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated10 mg/1oralReady Meds2012-03-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated20 mg/1oralJubilant Cadista Pharmaceuticals Inc.2012-09-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated10 mg/1oralLake Erie Medical DBA Quality Care Products LLC2012-03-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated20 mg/1oralAurobindo Pharma Limited2012-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated20 mg/1oralREMEDYREPACK INC.2014-12-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated10 mg/1oralNorthwind Pharmaceuticals, LLC2015-02-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated20 mg/1oralWest Ward Pharmaceuticals Corp2012-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated10 mg/1oralAccord Healthcare Inc.2013-01-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated20 mg/1oralInternational Labs, Inc.2013-09-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated10 mg/1oralDispensing Solutions, Inc.2012-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated5 mg/1oralbryant ranch prepack2012-03-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated10 mg/1oralJubilant Cadista Pharmaceuticals Inc.2012-09-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated10 mg/1oralPd Rx Pharmaceuticals, Inc.2012-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated20 mg/1oralMajor Pharmaceuticals2012-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated10 mg/1oralAidarex Pharmaceuticals LLC2012-03-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated10 mg/1oralAurobindo Pharma Limited2012-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated20 mg/1oralREMEDYREPACK INC.2014-11-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated10 mg/1oralUnit Dose Services2012-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated20 mg/1oralTeva Pharmaceuticals USA Inc2012-03-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated5 mg/1oralAccord Healthcare Inc.2013-01-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet20 mg/1oralREMEDYREPACK INC.2014-02-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet5 mg/1oralLupin Pharmaceuticals, Inc.2012-09-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated20 mg/1oralbryant ranch prepack2012-03-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated5 mg/1oralJubilant Cadista Pharmaceuticals Inc.2014-11-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated10 mg/1oralPd Rx Pharmaceuticals, Inc.2012-03-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated10 mg/1oralCardinal Health2013-07-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated5 mg/1oralAurobindo Pharma Limited2012-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated10 mg/1oralREMEDYREPACK INC.2014-11-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated20 mg/1oralUnit Dose Services2012-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated10 mg/1oralMajor Pharmaceuticals2012-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated10 mg/1oralSolco Healthcare US, LLC2012-03-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated20 mg/1oralAmerican Health Packaging2013-07-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated10 mg/1oralProficient Rx LP2012-03-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated20 mg/1oralREMEDYREPACK INC.2013-05-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated10 mg/1oralLake Erie Medical DBA Quality Care Products LLC2013-05-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated5 mg/1oralHikma Pharmaceutical2012-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated10 mg/1oralREMEDYREPACK INC.2013-09-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet20 mg/1oralLupin Pharmaceuticals, Inc.2012-09-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated10 mg/1oralbryant ranch prepack2012-03-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated20 mg/1oralHikma Pharmaceutical2012-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated20 mg/1oralSTAT Rx USA LLC2012-03-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated10 mg/1oralTeva Pharmaceuticals USA Inc2012-03-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated10 mg/1oralPreferred Pharmaceuticals, Inc.2013-01-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated20 mg/1oralSt. Mary's Medical Park Pharmacy2014-02-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated10 mg/1oralUnit Dose Services2012-03-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated20 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2012-03-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet20 mg/1oralCamber Pharmaceuticals2012-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated20 mg/1oralSTI Pharma LLC2013-09-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated5 mg/1oralSolco Healthcare US, LLC2012-03-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated10 mg/1oralAmerican Health Packaging2013-07-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, coated20 mg/1oralDIRECT RX2015-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated20 mg/1oralREMEDYREPACK INC.2013-05-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopramtablet, film coated20 mg/1oralLake Erie Medical DBA Quality Care Products LLC2013-05-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopram Oxalatetablet10 mg/1oralTorrent Pharmaceuticals Limited2012-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopram Oxalatesolution5 mg/5mLoralAmneal Pharmaceuticals of New York, LLC2011-09-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopram Oxalatetablet10 mg/1oralDIRECT RX2015-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopram Oxalatetablet10 mg/1oralBlenheim Pharmacal, Inc.2013-11-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopram Oxalatetablet, film coated20 mg/21oralMacleods Pharmaceuticals Limited2012-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopram Oxalatetablet5 mg/1oralBlenheim Pharmacal, Inc.2013-11-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopram Oxalatetablet, film coated10 mg/21oralMacleods Pharmaceuticals Limited2012-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopram Oxalatetablet20 mg/1oralDIRECT RX2015-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopram Oxalatesolution5 mg/5mLoralSilarx Pharmaceuticals, Inc2013-06-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopram Oxalatetablet20 mg/1oralMajor Pharmaceuticals2014-10-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopram Oxalatetablet, film coated5 mg/1oralMacleods Pharmaceuticals Limited2012-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopram Oxalatetablet, film coated20 mg/1oralExelan Pharmaceuticals Inc.2012-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopram Oxalatetablet10 mg/1oralMajor Pharmaceuticals2014-10-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopram Oxalatetablet20 mg/1oralAidarex Pharmaceuticals LLC2012-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopram Oxalatetablet, film coated10 mg/1oralExelan Pharmaceuticals Inc.2012-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopram Oxalatetablet10 mg/1oralCardinal Health2014-10-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopram Oxalatetablet, film coated5 mg/1oralExelan Pharmaceuticals Inc.2012-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopram Oxalatesolution5 mg/5mLoralLeading Pharma, Llc2015-08-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopram Oxalatesolution5 mg/5mLoralCamber Pharmaceuticals, Inc.2012-06-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopram Oxalatetablet5 mg/1oralTorrent Pharmaceuticals Limited2012-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopram Oxalatetablet20 mg/1oralTorrent Pharmaceuticals Limited2012-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopram Oxalatesolution5 mg/5mLoralAurobindo Pharma Limited2012-04-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopram Oxalatetablet20 mg/1oralBlenheim Pharmacal, Inc.2013-11-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Escitalopram Oxalatesolution5 mg/5mLoralCitron Pharma LLC2012-04-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Over the Counter ProductsNot Available
International Brands
NameCompany
CipralexNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
CAS number128196-01-0
WeightAverage: 324.3919
Monoisotopic: 324.163791509
Chemical FormulaC20H21FN2O
InChI KeyInChIKey=WSEQXVZVJXJVFP-FQEVSTJZSA-N
InChI
InChI=1S/C20H21FN2O/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20/h4-9,12H,3,10-11,14H2,1-2H3/t20-/m0/s1
IUPAC Name
(1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile
SMILES
CN(C)CCC[C@]1(OCC2=C1C=CC(=C2)C#N)C1=CC=C(F)C=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as phenylbutylamines. These are compounds containing a phenylbutylamine moiety, which consists of a phenyl group substituted at the fourth carbon by an butan-1-amine.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassPhenylbutylamines
Direct ParentPhenylbutylamines
Alternative Parents
Substituents
  • Phenylbutylamine
  • Benzonitrile
  • Aralkylamine
  • Halobenzene
  • Fluorobenzene
  • Aryl halide
  • Aryl fluoride
  • Tertiary aliphatic amine
  • Tertiary amine
  • Oxacycle
  • Organoheterocyclic compound
  • Nitrile
  • Carbonitrile
  • Ether
  • Dialkyl ether
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Organofluoride
  • Organohalogen compound
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
  • 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile (CHEBI:36791 )
Pharmacology
IndicationLabeled indications include major depressive disorder (MDD) and generalized anxiety disorder (GAD). Unlabeled indications include treatment of mild dementia-associated agitation in nonpsychotic patients.
PharmacodynamicsEscitalopram is one of a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs). It is used to treat the depression associated with mood disorders. It is also used on occassion in the treatment of body dysmorphic disorder and anxiety. The antidepressant, antiobsessive-compulsive, and antibulimic actions of escitalopram are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin. In vitro studies show that escitalopram is a potent and selective inhibitor of neuronal serotonin reuptake and has only very weak effects on norepinephrine and dopamine neuronal reuptake. Escitalopram has no significant affinity for adrenergic (alpha1, alpha2, beta), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5HT1A, 5HT1B, 5HT2), or benzodiazepine receptors; antagonism of such receptors has been hypothesized to be associated with various anticholinergic, sedative, and cardiovascular effects for other psychotropic drugs. The chronic administration of escitalopram was found to downregulate brain norepinephrine receptors, as has been observed with other drugs effective in the treatment of major depressive disorder. Escitalopram does not inhibit monoamine oxidase.
Mechanism of actionThe antidepressant, antiobsessive-compulsive, and antibulimic actions of escitalopram are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin. Escitalopram blocks the reuptake of serotonin at the serotonin reuptake pump of the neuronal membrane, enhancing the actions of serotonin on 5HT1A autoreceptors. SSRIs bind with significantly less affinity to histamine, acetylcholine, and norepinephrine receptors than tricyclic antidepressant drugs.
AbsorptionThe absolute bioavailability of citalopram is about 80% relative to an intravenous dose.
Volume of distribution
  • 12 L/kg
Protein binding~56%
Metabolism

Mainly hepatic. Escitalopram undergoes N-demethylation to S-demethylcitalopram (S-DCT) and S-didemethylcitalopram (S-DDCT). CYP3A4 and CYP2C19 are the enzymes responsible for this N-demethylation reaction.

Route of eliminationFollowing oral administrations of escitalopram, the fraction of drug recovered in the urine as escitalopram and S-demethylcitalopram (S-DCT) is about 8% and 10%, respectively. The oral clearance of escitalopram is 600 mL/min, with approximately 7% of that due to renal clearance. Escitalopram is metabolized to S-DCT and S-didemethylcitalopram (S-DDCT).
Half life27-32 hours
Clearance
  • oral cl=600 mL/min [Following oral administrations]
ToxicitySigns of overdose include convulsions, coma, dizziness, hypotension, insomnia, nausea, vomiting, sinus tachycardia, somnolence, and ECG changes (including QT prolongation).
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug Reactions
Interacting Gene/EnzymeSNP RS IDAllele nameDefining changeAdverse ReactionReference(s)
Sodium-dependent serotonin transporter
Gene symbol: SLC6A4
UniProt: P31645
rs25531 Not AvailableA alleleIncrease risk of side effects (ie. headaches)19272758
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9966
Blood Brain Barrier+0.9729
Caco-2 permeable+0.6099
P-glycoprotein substrateSubstrate0.7597
P-glycoprotein inhibitor INon-inhibitor0.6361
P-glycoprotein inhibitor IIInhibitor0.9789
Renal organic cation transporterInhibitor0.6993
CYP450 2C9 substrateNon-substrate0.8401
CYP450 2D6 substrateSubstrate0.8919
CYP450 3A4 substrateSubstrate0.7407
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorInhibitor0.8949
CYP450 2D6 inhibitorNon-inhibitor0.5054
CYP450 2C19 inhibitorInhibitor0.8994
CYP450 3A4 inhibitorNon-inhibitor0.8309
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.5223
Ames testNon AMES toxic0.7602
CarcinogenicityNon-carcinogens0.7452
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.9054 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.7735
hERG inhibition (predictor II)Inhibitor0.8994
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Tabletoral5 mg
Tabletoral10 mg
Tabletoral15 mg
Tabletoral20 mg
Tablet (orally disintegrating)oral10 mg
Tablet (orally disintegrating)oral20 mg
Tablet, coatedoral20 mg/1
Tablet, film coatedoral10 mg/1
Tablet, film coatedoral20 mg/1
Tablet, film coatedoral5 mg/1
Tabletoral10 mg/1
Tabletoral20 mg/1
Tabletoral5 mg/1
Tablet, film coatedoral10 mg/21
Tablet, film coatedoral20 mg/21
Solutionoral5 mg/5mL
Prices
Unit descriptionCostUnit
Lexapro 20 mg tablet3.71USD tablet
Lexapro 10 mg tablet3.55USD tablet
Lexapro 5 mg tablet3.4USD tablet
Lexapro 5 mg/5ml Solution0.72USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
CountryPatent NumberApprovedExpires (estimated)
Canada13394521997-09-092014-09-09
Canada23737572010-01-052020-07-07
United States69169412003-02-122023-02-12
United StatesRE347121994-09-142011-09-14
Properties
StateSolid
Experimental Properties
PropertyValueSource
logP3.5Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00588 mg/mLALOGPS
logP3.58ALOGPS
logP3.76ChemAxon
logS-4.7ALOGPS
pKa (Strongest Basic)9.78ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area36.26 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity94.02 m3·mol-1ChemAxon
Polarizability35.21 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis Reference

Robert Dancer, “Escitalopram hydrobromide and a method for the preparation thereof.” U.S. Patent US20040167209, issued August 26, 2004.

US20040167209
General References
  1. Moore N, Verdoux H, Fantino B: Prospective, multicentre, randomized, double-blind study of the efficacy of escitalopram versus citalopram in outpatient treatment of major depressive disorder. Int Clin Psychopharmacol. 2005 May;20(3):131-7. Pubmed
  2. Boulenger JP, Huusom AK, Florea I, Baekdal T, Sarchiapone M: A comparative study of the efficacy of long-term treatment with escitalopram and paroxetine in severely depressed patients. Curr Med Res Opin. 2006 Jul;22(7):1331-41. Pubmed
  3. Bielski RJ, Ventura D, Chang CC: A double-blind comparison of escitalopram and venlafaxine extended release in the treatment of major depressive disorder. J Clin Psychiatry. 2004 Sep;65(9):1190-6. Pubmed
  4. Nierenberg AA, Greist JH, Mallinckrodt CH, Prakash A, Sambunaris A, Tollefson GD, Wohlreich MM: Duloxetine versus escitalopram and placebo in the treatment of patients with major depressive disorder: onset of antidepressant action, a non-inferiority study. Curr Med Res Opin. 2007 Feb;23(2):401-16. Pubmed
  5. Chen F, Larsen MB, Sanchez C, Wiborg O: The S-enantiomer of R,S-citalopram, increases inhibitor binding to the human serotonin transporter by an allosteric mechanism. Comparison with other serotonin transporter inhibitors. Eur Neuropsychopharmacol. 2005 Mar;15(2):193-8. Pubmed
External Links
ATC CodesN06AB10
AHFS Codes
  • 28:16.04.20
PDB EntriesNot Available
FDA labelDownload (1.09 MB)
MSDSNot Available
Interactions
Drug Interactions
Drug
AbciximabEscitalopram may increase the anticoagulant activities of Abciximab.
AcenocoumarolEscitalopram may increase the anticoagulant activities of Acenocoumarol.
AcepromazineThe risk or severity of adverse effects can be increased when Escitalopram is combined with Acepromazine.
AcetophenazineThe risk or severity of adverse effects can be increased when Escitalopram is combined with Acetophenazine.
Acetylsalicylic acidEscitalopram may increase the antiplatelet activities of Acetylsalicylic acid.
AlteplaseEscitalopram may increase the anticoagulant activities of Alteplase.
AmisulprideThe risk or severity of adverse effects can be increased when Escitalopram is combined with Amisulpride.
AmitriptylineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Escitalopram.
AmoxapineThe risk or severity of adverse effects can be increased when Amoxapine is combined with Escitalopram.
AnistreplaseEscitalopram may increase the anticoagulant activities of Anistreplase.
ApixabanThe risk or severity of adverse effects can be increased when Escitalopram is combined with Apixaban.
AprepitantThe serum concentration of Escitalopram can be increased when it is combined with Aprepitant.
AripiprazoleThe risk or severity of adverse effects can be increased when Escitalopram is combined with Aripiprazole.
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Escitalopram.
BenzquinamideThe risk or severity of adverse effects can be increased when Escitalopram is combined with Benzquinamide.
BexaroteneThe serum concentration of Escitalopram can be decreased when it is combined with Bexarotene.
BoceprevirThe serum concentration of Escitalopram can be decreased when it is combined with Boceprevir.
BortezomibThe metabolism of Escitalopram can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Escitalopram can be decreased when it is combined with Bosentan.
BuspironeBuspirone may increase the serotonergic activities of Escitalopram.
CarbamazepineThe metabolism of Carbamazepine can be decreased when combined with Escitalopram.
CarphenazineThe risk or severity of adverse effects can be increased when Escitalopram is combined with Carphenazine.
ChlormezanoneThe risk or severity of adverse effects can be increased when Escitalopram is combined with Chlormezanone.
ChlorpromazineThe risk or severity of adverse effects can be increased when Escitalopram is combined with Chlorpromazine.
ChlorprothixeneThe risk or severity of adverse effects can be increased when Escitalopram is combined with Chlorprothixene.
CimetidineThe serum concentration of Escitalopram can be increased when it is combined with Cimetidine.
CitalopramCitalopram may increase the QTc-prolonging activities of EsCitalopram.
Citric AcidEscitalopram may increase the anticoagulant activities of Citric Acid.
ClomipramineThe risk or severity of adverse effects can be increased when Clomipramine is combined with Escitalopram.
ClozapineThe risk or severity of adverse effects can be increased when Escitalopram is combined with Clozapine.
CollagenaseThe risk or severity of adverse effects can be increased when Escitalopram is combined with Collagenase.
ConivaptanThe serum concentration of Escitalopram can be increased when it is combined with Conivaptan.
CyproheptadineThe therapeutic efficacy of Escitalopram can be decreased when used in combination with Cyproheptadine.
Dabigatran etexilateEscitalopram may increase the anticoagulant activities of Dabigatran etexilate.
DabrafenibThe serum concentration of Escitalopram can be decreased when it is combined with Dabrafenib.
DalteparinEscitalopram may increase the anticoagulant activities of Dalteparin.
DapoxetineThe risk or severity of adverse effects can be increased when Dapoxetine is combined with Escitalopram.
DeferasiroxThe serum concentration of Escitalopram can be decreased when it is combined with Deferasirox.
Deoxycholic AcidThe risk or severity of adverse effects can be increased when Escitalopram is combined with Deoxycholic Acid.
DesipramineThe risk or severity of adverse effects can be increased when Desipramine is combined with Escitalopram.
DesmopressinThe risk or severity of adverse effects can be increased when Escitalopram is combined with Desmopressin.
DextromethorphanEscitalopram may increase the serotonergic activities of Dextromethorphan.
DicoumarolEscitalopram may increase the anticoagulant activities of Dicoumarol.
DofetilideDofetilide may increase the QTc-prolonging activities of Escitalopram.
DosulepinThe serum concentration of Dosulepin can be increased when it is combined with Escitalopram.
DoxepinThe risk or severity of adverse effects can be increased when Doxepin is combined with Escitalopram.
DroperidolThe risk or severity of adverse effects can be increased when Escitalopram is combined with Droperidol.
Edetic AcidEscitalopram may increase the anticoagulant activities of Edetic Acid.
EnoxaparinEscitalopram may increase the anticoagulant activities of Enoxaparin.
EthanolThe risk or severity of adverse effects can be increased when Ethanol is combined with Escitalopram.
Ethyl biscoumacetateEscitalopram may increase the anticoagulant activities of Ethyl biscoumacetate.
FencamfamineThe risk or severity of adverse effects can be increased when Escitalopram is combined with Fencamfamine.
FluconazoleThe metabolism of Escitalopram can be decreased when combined with Fluconazole.
FlupentixolThe risk or severity of adverse effects can be increased when Escitalopram is combined with Flupentixol.
FluphenazineThe risk or severity of adverse effects can be increased when Escitalopram is combined with Fluphenazine.
FluspirileneThe risk or severity of adverse effects can be increased when Escitalopram is combined with Fluspirilene.
FluvoxamineThe metabolism of Escitalopram can be decreased when combined with Fluvoxamine.
Fondaparinux sodiumEscitalopram may increase the anticoagulant activities of Fondaparinux sodium.
FosaprepitantThe serum concentration of Escitalopram can be increased when it is combined with Fosaprepitant.
Fusidic AcidThe serum concentration of Escitalopram can be increased when it is combined with Fusidic Acid.
GlucosamineGlucosamine may increase the antiplatelet activities of Escitalopram.
GoserelinGoserelin may increase the QTc-prolonging activities of Escitalopram.
GranisetronGranisetron may increase the serotonergic activities of Escitalopram.
HaloperidolThe risk or severity of adverse effects can be increased when Escitalopram is combined with Haloperidol.
HeparinEscitalopram may increase the anticoagulant activities of Heparin.
IbritumomabThe risk or severity of adverse effects can be increased when Escitalopram is combined with Ibritumomab.
IbrutinibThe risk or severity of adverse effects can be increased when Ibrutinib is combined with Escitalopram.
IcosapentEscitalopram may increase the antiplatelet activities of Icosapent.
IdelalisibThe serum concentration of Escitalopram can be increased when it is combined with Idelalisib.
ImipramineThe risk or severity of adverse effects can be increased when Imipramine is combined with Escitalopram.
Insulin RegularEscitalopram may increase the hypoglycemic activities of Insulin Regular.
IobenguaneThe therapeutic efficacy of Iobenguane can be decreased when used in combination with Escitalopram.
Ioflupane I 123Escitalopram may decrease effectiveness of Ioflupane I 123 as a diagnostic agent.
IvabradineIvabradine may increase the QTc-prolonging activities of Escitalopram.
IvacaftorThe serum concentration of Escitalopram can be increased when it is combined with Ivacaftor.
L-TryptophanL-Tryptophan may increase the serotonergic activities of Escitalopram.
LeuprolideLeuprolide may increase the QTc-prolonging activities of Escitalopram.
LimaprostLimaprost may increase the antiplatelet activities of Escitalopram.
LinezolidLinezolid may increase the serotonergic activities of Escitalopram.
LiothyronineThe therapeutic efficacy of Liothyronine can be decreased when used in combination with Escitalopram.
LithiumLithium may increase the serotonergic activities of Escitalopram.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Escitalopram.
LoxapineThe risk or severity of adverse effects can be increased when Escitalopram is combined with Loxapine.
LuliconazoleThe serum concentration of Escitalopram can be increased when it is combined with Luliconazole.
MesoridazineThe risk or severity of adverse effects can be increased when Escitalopram is combined with Mesoridazine.
MethotrimeprazineThe risk or severity of adverse effects can be increased when Escitalopram is combined with Methotrimeprazine.
Methylene blueEscitalopram may increase the serotonergic activities of Methylene blue.
MetoclopramideThe risk or severity of adverse effects can be increased when Metoclopramide is combined with Escitalopram.
MetyrosineThe risk or severity of adverse effects can be increased when Metyrosine is combined with Escitalopram.
MexiletineThe metabolism of Mexiletine can be decreased when combined with Escitalopram.
MifepristoneMifepristone may increase the QTc-prolonging activities of Escitalopram.
MitotaneThe serum concentration of Escitalopram can be decreased when it is combined with Mitotane.
MolindoneThe risk or severity of adverse effects can be increased when Escitalopram is combined with Molindone.
MorphineMorphine may increase the serotonergic activities of Escitalopram.
NelfinavirThe metabolism of Escitalopram can be decreased when combined with Nelfinavir.
NetupitantThe serum concentration of Escitalopram can be increased when it is combined with Netupitant.
NortriptylineThe risk or severity of adverse effects can be increased when Nortriptyline is combined with Escitalopram.
ObinutuzumabThe risk or severity of adverse effects can be increased when Escitalopram is combined with Obinutuzumab.
OctreotideOctreotide may increase the QTc-prolonging activities of Escitalopram.
OlanzapineThe risk or severity of adverse effects can be increased when Escitalopram is combined with Olanzapine.
Omega-3 fatty acidsOmega-3 fatty acids may increase the antiplatelet activities of Escitalopram.
OmeprazoleThe serum concentration of Escitalopram can be increased when it is combined with Omeprazole.
OndansetronThe risk or severity of adverse effects can be increased when Escitalopram is combined with Ondansetron.
PalbociclibThe serum concentration of Escitalopram can be increased when it is combined with Palbociclib.
PaliperidoneThe risk or severity of adverse effects can be increased when Escitalopram is combined with Paliperidone.
Pentosan PolysulfateThe risk or severity of adverse effects can be increased when Pentosan Polysulfate is combined with Escitalopram.
PentoxifyllinePentoxifylline may increase the antiplatelet activities of Escitalopram.
PerphenazineThe risk or severity of adverse effects can be increased when Escitalopram is combined with Perphenazine.
PhenelzinePhenelzine may increase the serotonergic activities of Escitalopram.
PhenindioneEscitalopram may increase the anticoagulant activities of Phenindione.
PhenprocoumonEscitalopram may increase the anticoagulant activities of Phenprocoumon.
PhenytoinThe metabolism of Escitalopram can be increased when combined with Phenytoin.
PimozideThe risk or severity of adverse effects can be increased when Escitalopram is combined with Pimozide.
PiperacetazineThe risk or severity of adverse effects can be increased when Escitalopram is combined with Piperacetazine.
ProchlorperazineThe risk or severity of adverse effects can be increased when Escitalopram is combined with Prochlorperazine.
PromazineThe risk or severity of adverse effects can be increased when Escitalopram is combined with Promazine.
ProtriptylineThe risk or severity of adverse effects can be increased when Protriptyline is combined with Escitalopram.
QuetiapineThe risk or severity of adverse effects can be increased when Escitalopram is combined with Quetiapine.
RemoxiprideThe risk or severity of adverse effects can be increased when Escitalopram is combined with Remoxipride.
ReserpineThe risk or severity of adverse effects can be increased when Escitalopram is combined with Reserpine.
ReteplaseEscitalopram may increase the anticoagulant activities of Reteplase.
RidogrelEscitalopram may increase the anticoagulant activities of Ridogrel.
RisperidoneThe risk or severity of adverse effects can be increased when Escitalopram is combined with Risperidone.
RivaroxabanEscitalopram may increase the anticoagulant activities of Rivaroxaban.
Salicylate-sodiumThe risk or severity of adverse effects can be increased when Escitalopram is combined with Salicylate-sodium.
SertindoleThe risk or severity of adverse effects can be increased when Escitalopram is combined with Sertindole.
SiltuximabThe serum concentration of Escitalopram can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Simeprevir can be decreased when it is combined with Escitalopram.
St. John's WortThe serum concentration of Escitalopram can be decreased when it is combined with St. John's Wort.
StiripentolThe serum concentration of Escitalopram can be increased when it is combined with Stiripentol.
StreptokinaseEscitalopram may increase the anticoagulant activities of Streptokinase.
SulodexideEscitalopram may increase the anticoagulant activities of Sulodexide.
SulpirideThe risk or severity of adverse effects can be increased when Escitalopram is combined with Sulpiride.
Tedizolid PhosphateTedizolid Phosphate may increase the serotonergic activities of Escitalopram.
TelaprevirThe serum concentration of Escitalopram can be decreased when it is combined with Telaprevir.
TenecteplaseEscitalopram may increase the anticoagulant activities of Tenecteplase.
ThioridazineThe risk or severity of adverse effects can be increased when Escitalopram is combined with Thioridazine.
ThiothixeneThe risk or severity of adverse effects can be increased when Escitalopram is combined with Thiothixene.
TipranavirTipranavir may increase the antiplatelet activities of Escitalopram.
TocilizumabThe serum concentration of Escitalopram can be decreased when it is combined with Tocilizumab.
TositumomabThe risk or severity of adverse effects can be increased when Escitalopram is combined with Tositumomab.
TramadolEscitalopram may increase the neuroexcitatory activities of Tramadol.
TranylcypromineTranylcypromine may increase the serotonergic activities of Escitalopram.
TrazodoneEscitalopram may increase the serotonergic activities of Trazodone.
TreprostinilEscitalopram may increase the anticoagulant activities of Treprostinil.
TrichlormethiazideEscitalopram may increase the activities of Trichlormethiazide.
TrifluoperazineThe risk or severity of adverse effects can be increased when Escitalopram is combined with Trifluoperazine.
TriflupromazineThe risk or severity of adverse effects can be increased when Escitalopram is combined with Triflupromazine.
TrimipramineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Escitalopram.
UrokinaseEscitalopram may increase the anticoagulant activities of Urokinase.
Vitamin EVitamin E may increase the antiplatelet activities of Escitalopram.
WarfarinEscitalopram may increase the anticoagulant activities of Warfarin.
ZiprasidoneThe risk or severity of adverse effects can be increased when Escitalopram is combined with Ziprasidone.
ZuclopenthixolThe risk or severity of adverse effects can be increased when Escitalopram is combined with Zuclopenthixol.
Food Interactions
  • Take without regard to meals.

Targets

1. Sodium-dependent serotonin transporter

Kind: Protein

Organism: Human

Pharmacological action: yes

Actions: inhibitor

Components

Name UniProt ID Details
Sodium-dependent serotonin transporter P31645 Details

References:

  1. Owens MJ, Knight DL, Nemeroff CB: Second-generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetine. Biol Psychiatry. 2001 Sep 1;50(5):345-50. Pubmed
  2. Owens JM, Knight DL, Nemeroff CB: [Second generation SSRIS: human monoamine transporter binding profile of escitalopram and R-fluoxetine] Encephale. 2002 Jul-Aug;28(4):350-5. Pubmed
  3. Burke WJ: Escitalopram. Expert Opin Investig Drugs. 2002 Oct;11(10):1477-86. Pubmed
  4. Waugh J, Goa KL: Escitalopram : a review of its use in the management of major depressive and anxiety disorders. CNS Drugs. 2003;17(5):343-62. Pubmed
  5. Sanchez C, Bergqvist PB, Brennum LT, Gupta S, Hogg S, Larsen A, Wiborg O: Escitalopram, the S-(+)-enantiomer of citalopram, is a selective serotonin reuptake inhibitor with potent effects in animal models predictive of antidepressant and anxiolytic activities. Psychopharmacology (Berl). 2003 Jun;167(4):353-62. Epub 2003 Apr 26. Pubmed
  6. Bareggi SR, Mundo E, Dell’Osso B, Altamura AC: The use of escitalopram beyond major depression: pharmacological aspects, efficacy and tolerability in anxiety disorders. Expert Opin Drug Metab Toxicol. 2007 Oct;3(5):741-53. Pubmed
  7. Fabre V, Hamon M: [Mechanisms of action of antidepressants: new data from Escitalopram] Encephale. 2003 May-Jun;29(3 Pt 1):259-65. Pubmed
  8. Zhong H, Hansen KB, Boyle NJ, Han K, Muske G, Huang X, Egebjerg J, Sanchez C: An allosteric binding site at the human serotonin transporter mediates the inhibition of escitalopram by R-citalopram: kinetic binding studies with the ALI/VFL-SI/TT mutant. Neurosci Lett. 2009 Oct 25;462(3):207-12. Epub 2009 Jul 16. Pubmed

2. Sodium-dependent dopamine transporter

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Sodium-dependent dopamine transporter Q01959 Details

References:

  1. Bareggi SR, Mundo E, Dell’Osso B, Altamura AC: The use of escitalopram beyond major depression: pharmacological aspects, efficacy and tolerability in anxiety disorders. Expert Opin Drug Metab Toxicol. 2007 Oct;3(5):741-53. Pubmed

3. Sodium-dependent noradrenaline transporter

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Sodium-dependent noradrenaline transporter P23975 Details

References:

  1. Bareggi SR, Mundo E, Dell’Osso B, Altamura AC: The use of escitalopram beyond major depression: pharmacological aspects, efficacy and tolerability in anxiety disorders. Expert Opin Drug Metab Toxicol. 2007 Oct;3(5):741-53. Pubmed

4. Alpha-1A adrenergic receptor

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: antagonist

Components

Name UniProt ID Details
Alpha-1A adrenergic receptor P35348 Details

References:

  1. Bareggi SR, Mundo E, Dell’Osso B, Altamura AC: The use of escitalopram beyond major depression: pharmacological aspects, efficacy and tolerability in anxiety disorders. Expert Opin Drug Metab Toxicol. 2007 Oct;3(5):741-53. Pubmed
  2. Fabre V, Hamon M: [Mechanisms of action of antidepressants: new data from Escitalopram] Encephale. 2003 May-Jun;29(3 Pt 1):259-65. Pubmed

5. Muscarinic acetylcholine receptor M1

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: antagonist

Components

Name UniProt ID Details
Muscarinic acetylcholine receptor M1 P11229 Details

References:

  1. Bareggi SR, Mundo E, Dell’Osso B, Altamura AC: The use of escitalopram beyond major depression: pharmacological aspects, efficacy and tolerability in anxiety disorders. Expert Opin Drug Metab Toxicol. 2007 Oct;3(5):741-53. Pubmed

6. Histamine H1 receptor

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: antagonist

Components

Name UniProt ID Details
Histamine H1 receptor P35367 Details

References:

  1. Bareggi SR, Mundo E, Dell’Osso B, Altamura AC: The use of escitalopram beyond major depression: pharmacological aspects, efficacy and tolerability in anxiety disorders. Expert Opin Drug Metab Toxicol. 2007 Oct;3(5):741-53. Pubmed
  2. Fabre V, Hamon M: [Mechanisms of action of antidepressants: new data from Escitalopram] Encephale. 2003 May-Jun;29(3 Pt 1):259-65. Pubmed

Enzymes

1. Cytochrome P450 3A4

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 3A4 P08684 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

2. Cytochrome P450 2C19

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 2C19 P33261 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

3. Cytochrome P450 2D6

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Cytochrome P450 2D6 P10635 Details

References:

  1. Baumann P: Pharmacokinetic-pharmacodynamic relationship of the selective serotonin reuptake inhibitors. Clin Pharmacokinet. 1996 Dec;31(6):444-69. Pubmed
  2. Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). Accessed May 28, 2010.
  3. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

Comments
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Drug created on June 13, 2005 07:24 / Updated on September 16, 2013 17:13