Reaction: Praziquantel to 1 product
- Reaction
- Reaction type
- 4-hydroxylation
- Direction
- Major circulating metabolite?
- No
- Spontaneous?
- No
- Activity
- unknown
- References
- Kapungu NN, Li X, Nhachi C, Masimirembwa C, Thelingwani RS: In vitro and in vivo human metabolism and pharmacokinetics of S- and R-praziquantel. Pharmacol Res Perspect. 2020 Aug;8(4):e00618. doi: 10.1002/prp2.618. [Article]
- da Silva VBR, Campos BRKL, de Oliveira JF, Decout JL, do Carmo Alves de Lima M: Medicinal chemistry of antischistosomal drugs: Praziquantel and oxamniquine. Bioorg Med Chem. 2017 Jul 1;25(13):3259-3277. doi: 10.1016/j.bmc.2017.04.031. Epub 2017 Apr 27. [Article]
- Vendrell-Navarro G, Scheible H, Lignet F, Burt H, Luepfert C, Marx A, Abla N, Swart P, Perrin D: Insights into Praziquantel Metabolism and Potential Enantiomeric Cytochrome P450-Mediated Drug-Drug Interaction. Drug Metab Dispos. 2020 Jun;48(6):481-490. doi: 10.1124/dmd.119.089888. Epub 2020 Mar 19. [Article]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role Cytochrome P450 1A2 Not Available Not Available implied Cytochrome P450 2C9 Not Available Not Available implied Cytochrome P450 2C19 Not Available Not Available implied Cytochrome P450 3A4 Not Available Not Available implied
