Cysteamine bitartrateProduct ingredient for Cysteamine
- Name
- Cysteamine bitartrate
- Drug Entry
- Cysteamine
Cystinosis is a rare disease caused by mutations in the CTNS gene that encodes for cystinosin, a protein responsible for transporting cystine out of the cell lysosome. A defect in cystinosin function is followed by cystine accumulation throughout the body, especially the eyes and kidneys.2
Several preparations of cysteamine exist for the treatment of cystinosis manifestations, some in capsule form, and others in ophthalmic solution form.10,12 In particular, cystine deposits on the eye can cause significant discomfort throughout the day and require frequent treatment with eye drops, typically every waking hour.11
On August 25th 2020, the first ophthalmic solution for cystinosis requiring only 4 daily treatments was granted FDA approval.10 Cysteamine eye drops are a practical and effective option for those affected by ocular cystinosis. Marketed by Recordati Rare Diseases Inc., CYSTADROPS® reduce the burden of multiple frequent medications normally administered to those with cystinosis.9
- Accession Number
- DBSALT000032
- Structure
Structure for Cysteamine bitartrate (DBSALT000032)
- Synonyms
- Cysteamine bitartrate / Mercamine bitartrate / Mercaptamine bitartrate
- External IDs
- RP-103
- UNII
- QO84GZ3TST
- CAS Number
- 27761-19-9
- Weight
- Average: 227.23
Monoisotopic: 227.046358317 - Chemical Formula
- C6H13NO6S
- InChI Key
- NSKJTUFFDRENDM-ZVGUSBNCSA-N
- InChI
- InChI=1S/C4H6O6.C2H7NS/c5-1(3(7)8)2(6)4(9)10;3-1-2-4/h1-2,5-6H,(H,7,8)(H,9,10);4H,1-3H2/t1-,2-;/m1./s1
- IUPAC Name
- (2R,3R)-2,3-dihydroxybutanedioic acid; 2-aminoethane-1-thiol
- SMILES
- NCCS.O[C@H]([C@@H](O)C(O)=O)C(O)=O
- External Links
- PubChem Compound
- 23111531
- ChemSpider
- 10132394
- ChEBI
- 50386
- ChEMBL
- CHEMBL2062263
- Wikipedia
- Cysteamine
- Predicted Properties
Property Value Source logP -1.8 Chemaxon pKa (Strongest Acidic) 2.72 Chemaxon pKa (Strongest Basic) -4.3 Chemaxon Physiological Charge -2 Chemaxon Hydrogen Acceptor Count 6 Chemaxon Hydrogen Donor Count 4 Chemaxon Polar Surface Area 115.06 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 26.21 m3·mol-1 Chemaxon Polarizability 11.69 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon