Memantine hydrochlorideProduct ingredient for Memantine
- Name
- Memantine hydrochloride
- Drug Entry
- Memantine
Initially approved by the FDA in 2013, memantine is an N-methyl-D-aspartate (NMDA) receptor antagonist used in the management of Alzheimer's Disease (AD). It is different from many other Alzheimer's Disease medications, as it works by a different mechanism than the cholinesterase enzyme inhibitors normally employed in the management of Alzheimer's disease 2. Memantine blocks the effects of glutamate, a neurotransmitter in the brain that leads to neuronal excitability and excessive stimulation in Alzheimer's Disease 9.
In 2010, it was estimated that 36 million people worldwide live with Alzheimer's Disease. In 2013, this number increased to 44 million. Almost doubling every 20 years, the prevalence of Alzheimer's Disease is predicted to reach 66 million by 2030 and to 115 million by 2050 13. In December 2013, the G8 dementia summit concluded that dementia should be considered a global priority with the objective of developing a cure or a disease-modifying therapy by the year 2025 10,13.
- Accession Number
- DBSALT000456
- Structure
Structure for Memantine hydrochloride (DBSALT000456)
- Synonyms
- Memantine HCl
- UNII
- JY0WD0UA60
- CAS Number
- 41100-52-1
- Weight
- Average: 215.763
Monoisotopic: 215.144077416 - Chemical Formula
- C12H22ClN
- InChI Key
- LDDHMLJTFXJGPI-UHFFFAOYSA-N
- InChI
- InChI=1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H
- IUPAC Name
- 3,5-dimethyladamantan-1-amine hydrochloride
- SMILES
- Cl.CC12CC3CC(C)(C1)CC(N)(C3)C2
- External Links
- PubChem Compound
- 181458
- ChemSpider
- 157849
- ChEBI
- 64323
- ChEMBL
- CHEMBL1699
- Wikipedia
- Memantine
- Predicted Properties
Property Value Source Water Solubility 0.0455 mg/mL ALOGPS logP 3.31 ALOGPS logP 2.07 Chemaxon logS -3.6 ALOGPS pKa (Strongest Basic) 10.7 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 1 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 26.02 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 54.49 m3·mol-1 Chemaxon Polarizability 21.82 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon