Tranylcypromine sulfateProduct ingredient for Tranylcypromine
- Name
- Tranylcypromine sulfate
- Drug Entry
- Tranylcypromine
A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders (From AMA Drug Evaluations Annual, 1994, p311).
Tranylcypromine is a racemate comprising equal amounts of (1R,2S)- and (1S,2R)-2-phenylcyclopropan-1-amine with the chiral centers both located on the cylopropane ring. An irreversible monoamine oxidase inhibitor that is used as an antidepressant (INN tranylcypromine).
- Accession Number
- DBSALT000960
- Structure
- Synonyms
- Not Available
- UNII
- 7ZAT6ES870
- CAS Number
- 13492-01-8
- Weight
- Average: 364.46
Monoisotopic: 364.145678435 - Chemical Formula
- C18H24N2O4S
- InChI Key
- BKPRVQDIOGQWTG-KAVFMPKWSA-N
- InChI
- InChI=1S/2C9H11N.H2O4S/c2*10-9-6-8(9)7-4-2-1-3-5-7;1-5(2,3)4/h2*1-5,8-9H,6,10H2;(H2,1,2,3,4)/t2*8-,9+;/m11./s1
- IUPAC Name
- bis((1S,2R)-2-phenylcyclopropan-1-amine); sulfuric acid
- SMILES
- OS(O)(=O)=O.N[C@H]1C[C@@H]1C1=CC=CC=C1.N[C@H]1C[C@@H]1C1=CC=CC=C1
- External Links
- ChemSpider
- 9648812
- Wikipedia
- Tranylcypromine
- Predicted Properties
Property Value Source Water Solubility 1.49 mg/mL ALOGPS logP 1.5 ALOGPS logP 1.34 Chemaxon logS -2 ALOGPS pKa (Strongest Basic) 9.62 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 1 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 26.02 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 41.7 m3·mol-1 Chemaxon Polarizability 15.51 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon